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Kobra Haghighi

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Stela Florea; Kobra Haghighi; Ahmad Anjak; Wen-Feng Cai; Sarah Figueria; John Lorenz; Jiang Qian; Jack Rubinstein; Elizabeth Vafiadaki; Evangelia G Kranias
Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging.
Kobra Haghighi; Ahmad Anjak; Donald M Bers; Julie Bossuyt; Guo-Chang Fan; Hanna Osinska; Tracy Pritchard; Jeffrey Robbins; Jack Rubinstein; Jason R Waggoner; Qunying Yuan; Evangelia G Kranias
The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase.
Jiang Qian; Patricia Rodriguez; Despina Sanoudou; Vivek P Singh; Weizhong Song; Elizabeth Vafiadaki; Hong-Sheng Wang; Yigang Wang; Qunying Yuan; Wenfeng Cai; Guo-Chang Fan; Stela M Florea; Kobra Haghighi; Chi Kung Lam; Tracy J Pritchard; Evangelia G Kranias
Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.

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All Publications

2012: Stela Florea; Kobra Haghighi; Ahmad Anjak; Wen-Feng Cai; Sarah Figueria; John Lorenz; Jiang Qian; Jack Rubinstein; Elizabeth Vafiadaki; Evangelia G Kranias
Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging.
Basic research in cardiology 2012;107(5):279.
2012: Kobra Haghighi; Ahmad Anjak; Donald M Bers; Julie Bossuyt; Guo-Chang Fan; Hanna Osinska; Tracy Pritchard; Jeffrey Robbins; Jack Rubinstein; Jason R Waggoner; Qunying Yuan; Evangelia G Kranias
The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase.
Journal of molecular and cellular cardiology 2012;52(3):773-82.
2011: Jiang Qian; Patricia Rodriguez; Despina Sanoudou; Vivek P Singh; Weizhong Song; Elizabeth Vafiadaki; Hong-Sheng Wang; Yigang Wang; Qunying Yuan; Wenfeng Cai; Guo-Chang Fan; Stela M Florea; Kobra Haghighi; Chi Kung Lam; Tracy J Pritchard; Evangelia G Kranias
Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.
Circulation research 2011;108(12):1429-38.
2008: Kobra Haghighi; Guoli Chen; Yoji Sato; Guo-Chang Fan; Suiwen He; Fotis Kolokathis; Luke Pater; Ioannis Paraskevaidis; W Keith Jones; Gerald W Dorn; Dimitrios Th Kremastinos; Evangelia G Kranias
A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.
Human mutation 2008;29(5):640-7.
2006: Kobra Haghighi; Fotis Kolokathis; Anthony O Gramolini; Jason R Waggoner; Luke Pater; Roy A Lynch; Guo-Chang Fan; Dimitris Tsiapras; Rohan R Parekh; Gerald W Dorn; David H MacLennan; Dimitrios Th Kremastinos; Evangelia G Kranias
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1388-93.
2004: Kobra Haghighi; Kimberly N Gregory; Evangelia G Kranias
Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy.
Biochemical and biophysical research communications 2004;322(4):1214-22.
2004: Kimberly N Gregory; Harvey Hahn; Kobra Haghighi; Yehia Marreez; Amy Odley; Gerald W Dorn; Evangelia G Kranias
Increased particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury.
Journal of molecular and cellular cardiology 2004;36(2):313-8.
2003: Albrecht G Schmidt; Kobra Haghighi; Beate Frank; Luke Pater; Gerald W Dorn; Richard A Walsh; Evangelia G Kranias
Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure.
Journal of molecular and cellular cardiology 2003;35(7):867-70.
2003: Kobra Haghighi; Fotis Kolokathis; Luke Pater; Roy A Lynch; Michio Asahi; Anthony O Gramolini; Guo-Chang Fan; Dimitris Tsiapras; Harvey S Hahn; Stamatis Adamopoulos; Stephen B Liggett; Gerald W Dorn; David H MacLennan; Dimitrios Th Kremastinos; Evangelia G Kranias
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
The Journal of clinical investigation 2003;111(6):869-76.
2003: Qiujing Song; Albrecht G Schmidt; Harvey S Hahn; Andrew N Carr; Beate Frank; Luke Pater; Michael J Gerst; Karen Young; Brian D Hoit; Bradley K McConnell; Kobra Haghighi; Christine E Seidman; Jonathan G Seidman; Gerald W Dorn; Evangelia G Kranias
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
The Journal of clinical investigation 2003;111(6):859-67.
2003: Takayoshi Isoda; Nazareno Paolocci; Kobra Haghighi; Congrong Wang; Yibin Wang; Dimitrios Georgakopoulos; Giuseppe Servillo; Maria Agnese Della Fazia; Evangelia G Kranias; Anna A DePaoli-Roach; Paolo Sassone-Corsi; David A Kass
Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):144-51.
2002: Guoxiang Chu; Kobra Haghighi; Evangelia G Kranias
From mouse to man: understanding heart failure through genetically altered mouse models.
Journal of cardiac failure 2002;8(6 Suppl):S432-49.
2001: Konrad Frank; L Mesnard-Rouiller; Guoxiang Chu; Karen B Young; Wen Zhao; Kobra Haghighi; Yoji Sato; Evangelia G Kranias
Structure and expression of the mouse cardiac calsequestrin gene.
Basic research in cardiology 2001;96(6):636-44.
2001: Kobra Haghighi; Albrecht G Schmidt; Brian D Hoit; Angela G Brittsan; Atsuko Yatani; J William Lester; Jing Zhai; Y Kimura; Gerald W Dorn; David H MacLennan; Evangelia G Kranias
Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure.
The Journal of biological chemistry 2001;276(26):24145-52.
1997: Kobra Haghighi; Vivek J Kadambi; KL Koss; W Luo; Judy M Harrer; S Ponniah; Z Zhou; Evangelia G Kranias
In vitro and in vivo promoter analyses of the mouse phospholamban gene.
Gene 1997;203(2):199-207.
1997: Judy M Harrer; Kobra Haghighi; H W Kim; DG Ferguson; Evangelia G Kranias
Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart.
The American journal of physiology 1997;272(1 Pt 2):H57-66.
1996: W Luo; Beata M Wolska; Ingrid L Grupp; Judy M Harrer; Kobra Haghighi; DG Ferguson; Jay Slack; G Grupp; Thomas Doetschman; R John Solaro; Evangelia G Kranias
Phospholamban gene dosage effects in the mammalian heart.
Circulation research 1996;78(5):839-47.