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William Hagmann
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22
Mumford, Richard
21
Lin, Linus
20
MacCoss, Malcolm
19
McCauley, Ermengilda
18
Lanza, Thomas
17
Van Riper, Gail
16
Schmidt, John
12
de Laszlo, Stephen
12
Egger, Linda
12
Fong, Tung
12
Kidambi, Usha
11
Tong, Sharon
10
Jewell, James
9
Shen, Chun-Pyn
8
Tong, Xinchun
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All Publications
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2009: Du Wu; Jewell James P; Lin Linus S; Colandrea Vincent J; Xiao Jing C; Lao Julie; Shen Chun-Pyn; Bateman Thomas J; Reddy Vijay B G; Ha Sookhee N; Shah Shrenik K; Fong Tung M; Hale Jeffrey J; Hagmann William K
Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
Bioorganic & medicinal chemistry letters 2009;19(17):5195-9.
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2009: Treonze Kelly M; Alves Kenneth; Fischer Paul; Hagmann William K; Hora Donald; Kulick Alison; Vakerich Ken; Smith Nicholas D; Lingham Russell B; Maniar Salony; Reger Thomas S; Zunic Jasmine; Munoz Benito; Prasit Peppi; Nicholson Donald; Si Qian; Judd Keith; Nicolich Susan; Kellerhouse Patricia; Thompson Donald; Mumford Richard A
Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).
Veterinary immunology and immunopathology 2009;130(1-2):79-87.
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2009: Hamill Terence G; Lin Linus S; Hagmann William; Liu Ping; Jewell James; Sanabria Sandra; Eng WaiSi; Ryan Christine; Fong Tung M; Connolly Brett; Vanko Amy; Hargreaves Richard; Goulet Mark T; Burns H Donald
PET imaging studies in rhesus monkey with the cannabinoid-1 (CB1) receptor ligand [11C]CB-119.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2009;11(4):246-52.
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2009: Lin Linus S; Lanza Thomas; Jewell James P; Liu Ping; Jones Carrie; Kieczykowski Gerard R; Treonze Kelly; Si Qian; Manior Salony; Koo Gloria; Tong Xinchun; Wang Junying; Schuelke Anne; Pivnichny James; Wang Regina; Raab Conrad; Vincent Stella; Davies Philip; Maccoss Malcolm; Mumford Richard A; Hagmann William K
Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.
Journal of medicinal chemistry 2009;52(11):3449-52.
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2009: Vachal Petr; Fletcher Joan M; Fong Tung M; Huang Cathy C R-R; Lao Julie; Xiao Jing C; Shen Chun-Pyn; Strack Alison M; Shearman Lauren; Stribling Sloan; Chen Richard Z; Frassetto Andrea; Tong Xinchun; Wang Junying; Ball Richard G; Tsou Nancy N; Hickey Gerard J; Thompson Donald F; Faidley Terry D; Nicolich Susan; Achanfuo-Yeboah Joana; Hora Donald F; Hale Jeffrey J; Hagmann William K
1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.
Journal of medicinal chemistry 2009;52(8):2550-8.
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2008: Xiao Jing Chen; Jewell James P; Lin Linus S; Hagmann William K; Fong Tung M; Shen Chun-Pyn
Similar in vitro pharmacology of human cannabinoid CB1 receptor variants expressed in CHO cells.
Brain research 2008;1238():36-43.
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2008: Hagmann William K
The many roles for fluorine in medicinal chemistry.
Journal of medicinal chemistry 2008;51(15):4359-69.
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2008: Lin Linus S; Ha Sookhee; Ball Richard G; Tsou Nancy N; Castonguay Laurie A; Doss George A; Fong Tung M; Shen Chun-Pyn; Xiao Jing Chen; Goulet Mark T; Hagmann William K
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
Journal of medicinal chemistry 2008;51(7):2108-14.
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2008: Chang Linda L; Yang Ginger X; McCauley Ermengilda; Mumford Richard A; Schmidt John A; Hagmann William K
Constraining the amide bond in N-sulfonylated dipeptide VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2008;18(5):1688-91.
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2008: Tang W; Stearns R A; Chen Q; Bleasby K; Teffera Y; Colletti A; Hafey M; Evers R; Dean D C; Magriotis P A; Lanza T J; Lin L S; Hagmann W K; Baillie T A
Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(2):223-37.
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2008: Shearman Lauren P; Stribling D Sloan; Camacho Ramon E; Rosko Kimberly M; Wang Junying; Tong Sharon; Feng Yue; Marsh Donald J; Yu Hong; Guan Xiaoming; Spann Stephanie K; Macneil Douglas J; Fong Tung M; Metzger Joseph M; Goulet Mark T; Hagmann William K; Plummer Christopher W; Finke Paul E; Mills Sander G; Shah Shrenik K; Truong Quang; Van der Ploeg L H T; Macintyre D Euan; Strack Alison M
Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.
European journal of pharmacology 2008;579(1-3):215-24.
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2007: Liu Ping; Lin Linus S; Hamill Terence G; Jewell James P; Lanza Thomas J; Gibson Raymond E; Krause Stephen M; Ryan Christine; Eng Waisi; Sanabria Sandra; Tong Xinchun; Wang Junying; Levorse Dorothy A; Owens Karen A; Fong Tung M; Shen Chun-Pyn; Lao Julie; Kumar Sanjeev; Yin Wenji; Payack Joseph F; Springfield Shawn A; Hargreaves Richard; Burns H Donald; Goulet Mark T; Hagmann William K
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
Journal of medicinal chemistry 2007;50(15):3427-30.
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2007: Burns H Donald; Van Laere Koen; Sanabria-Bohórquez Sandra; Hamill Terence G; Bormans Guy; Eng Wai-si; Gibson Ray; Ryan Christine; Connolly Brett; Patel Shil; Krause Stephen; Vanko Amy; Van Hecken Anne; Dupont Patrick; De Lepeleire Inge; Rothenberg Paul; Stoch S Aubrey; Cote Josee; Hagmann William K; Jewell James P; Lin Linus S; Liu Ping; Goulet Mark T; Gottesdiener Keith; Wagner John A; de Hoon Jan; Mortelmans Luc; Fong Tung M; Hargreaves Richard J
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9800-5.
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2007: Fong Tung M; Guan Xiao-Ming; Marsh Donald J; Shen Chun-Pyn; Stribling D Sloan; Rosko Kim M; Lao Julie; Yu Hong; Feng Yue; Xiao Jing C; Van der Ploeg Lex H T; Goulet Mark T; Hagmann Williams K; Lin Linus S; Lanza Thomas J; Jewell James P; Liu Ping; Shah Shrenik K; Qi Hongbo; Tong Xinchun; Wang Junying; Xu Suoyu S; Francis Barbara; Strack Alison M; MacIntyre D Euan; Shearman Lauren P
Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1013-22.
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2007: Armstrong Helen E; Galka Amy; Lin Linus S; Lanza Thomas J; Jewell James P; Shah Shrenik K; Guthikonda Ravi; Truong Quang; Chang Linda L; Quaker Grace; Colandrea Vincent J; Tong Xinchun; Wang Junying; Xu Sherry; Fong Tung M; Shen Chun-Pyn; Lao Julie; Chen Jing; Shearman Lauren P; Stribling D Sloan; Rosko Kimberly; Strack Alison; Ha Sookhee; Van der Ploeg Lex; Goulet Mark T; Hagmann William K
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2007;17(8):2184-7.
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2007: Chang Linda L; Truong Quang; Doss George A; MacCoss Malcolm; Lyons Kathryn; McCauley Ermengilda; Mumford Richard; Forrest Gail; Vincent Stella; Schmidt John A; Hagmann William K
Highly constrained bicyclic VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(3):597-601.
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2006: Lin Linus S; Lanza Thomas J; Jewell James P; Liu Ping; Shah Shrenik K; Qi Hongbo; Tong Xinchun; Wang Junying; Xu Suoyu S; Fong Tung M; Shen Chun-Pyn; Lao Julie; Xiao Jing Chen; Shearman Lauren P; Stribling D Sloan; Rosko Kimberly; Strack Alison; Marsh Donald J; Feng Yue; Kumar Sanjeev; Samuel Koppara; Yin Wenji; Van der Ploeg Lex H T; Goulet Mark T; Hagmann William K
Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
Journal of medicinal chemistry 2006;49(26):7584-7.
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2006: Shen Chun-Pyn; Xiao Jing Chen; Armstrong Helen; Hagmann William; Fong Tung M
F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist.
European journal of pharmacology 2006;531(1-3):41-6.
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2004: Shankaran K; Donnelly Karla L; Shah Shrenik K; Caldwell Charles G; Chen Ping; Hagmann William K; Maccoss Malcolm; Humes John L; Pacholok Stephen G; Kelly Theresa M; Grant Stephan K; Wong Kenny K
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
Bioorganic & medicinal chemistry letters 2004;14(23):5907-11.
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2004: Lin Linus S; Lanza Thomas J; Castonguay Laurie A; Kamenecka Theodore; McCauley Ermenegilda; Van Riper Gail; Egger Linda A; Mumford Richard A; Tong Xinchun; MacCoss Malcolm; Schmidt John A; Hagmann William K
Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4.
Bioorganic & medicinal chemistry letters 2004;14(9):2331-4.
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2004: Kamenecka Theodore M; Park You-Jung; Lin Linus S; de Laszlo Stephen; McCauley Ermengilda D; Van Riper Gail; Egger Linda; Kidambi Usha; Mumford Richard A; Tong Sharon; Tang Wei; Colletti Adria; Teffera Yohannes; Stearns Ralph; MacCoss Malcolm; Schmidt John A; Hagmann William K
Amidines as amide bond replacements in VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(9):2323-6.
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2004: Hagmann William K
The discovery and potential of N-sulfonylated dipeptide VLA-4 antagonists.
Current topics in medicinal chemistry 2004;4(14):1461-71.
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2003: Egger Linda A; Cao Jin; McCallum Christine; Kidambi Usha; Van Riper Gail; McCauley Ermengilda; Mumford Richard A; Lanza Thomas J; Lin Linus S; de Laszlo Stephen E; Young David N; Yang Ginger; Dean Dennis C; Raab Conrad E; Wallace Mike A; Jones Allen N; Hagmann William K; Schmidt John A; Pepinsky R Blake; Scott Daniel M; Lee Wen-Cherng; Cornebise Mark A; Detmers Patricia A
A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.
The Journal of pharmacology and experimental therapeutics 2003;306(3):903-13.
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2003: Doherty George A; Yang Ginger X; Borges Edite; Tong Sharon; McCauley Ermengilda D; Treonz Kelly M; Van Riper Gail; Pacholok Stephen; Si Qian; Koo Gloria C; Shah Kashmira; Mumford Richard A; Hagmann William K
N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2003;13(11):1891-5.
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2003: Yang Ginger X; Hagmann William K
VLA-4 antagonists: potent inhibitors of lymphocyte migration.
Medicinal research reviews 2003;23(3):369-92.
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2003: Koo Gloria C; Shah Kashmira; Ding Gloria J F; Xiao Jianying; Wnek Richard; Doherty George; Tong Xin Chun; Pepinsky R Blake; Lin Ko-Chung; Hagmann William K; Kawka Douglas; Singer Irwin I
A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation.
American journal of respiratory and critical care medicine 2003;167(10):1400-9.
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2003: Gutteridge Clare E; de Laszlo Stephen E; Kamenecka Theodore M; McCauley Ermengilda; van Riper Gail; Mumford Richard A; Kidambi Usha; Egger Linda A; Tong Sharon; Hagmann William K
N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2003;13(5):885-90.
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2003: Samuel Koppara; Yin Wenji; Stearns Ralph A; Tang Yui S; Chaudhary Ashok G; Jewell James P; Lanza Thomas; Lin Linus S; Hagmann William K; Evans David C; Kumar Sanjeev
Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
Journal of mass spectrometry : JMS 2003;38(2):211-21.
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2002: Kopka Ihor E; Lin Linus S; Mumford Richard A; Lanza Thomas; Magriotis Plato A; Young David; DeLaszlo Stephen E; MacCoss Malcolm; Mills Sander G; Van Riper Gail; McCauley Ermengilda; Lyons Kathryn; Vincent Stella; Egger Linda A; Kidambi Usha; Stearns Ralph; Colletti Adria; Teffera Yohannes; Tong Sharon; Owens Karen; Levorse Dorothy; Schmidt John A; Hagmann William K
Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(17):2415-8.
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2002: Kamenecka Theodore M; Lanza Thomas; de Laszlo Stephen E; Li Bing; McCauley Ermengilda D; Van Riper Gail; Egger Linda A; Kidambi Usha; Mumford Richard A; Tong Sharon; MacCoss Malcolm; Schmidt John A; Hagmann William K
N-aryl-prolyl-dipeptides as potent antagonists of VLA-4.
Bioorganic & medicinal chemistry letters 2002;12(16):2205-8.
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2002: Li Bing; de Laszlo Stephen E; Kamenecka Theodore M; Kopka Ihor E; Durette Philippe L; Lanza Thomas; MacCoss Malcolm; Tong Sharon; Mumford Richard A; McCauley Ermengilda D; Van Riper Gail; Schmidt John A; Hagmann William K
N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(16):2141-4.
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2002: Egger Linda A; Kidambi Usha; Cao Jin; Van Riper Gail; McCauley Ermengilda; Mumford Richard A; Amo Suzanne; Lingham Russell; Lanza Thomas; Lin Linus S; De Laszlo Stephen E; Young David N; Kopka Ihor E; Tong Sharon; Pikounis Bill; Benson Evelyn; Warwood Sarah; Bargatze Robert F; Hagmann William K; Schmidt John A; Detmers Patricia A
Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.
The Journal of pharmacology and experimental therapeutics 2002;302(1):153-62.
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2002: Pepinsky R Blake; Mumford Richard A; Chen Ling Ling; Leone Diane; Amo Suzanne E; Riper Gail Van; Whitty Adrian; Dolinski Brian; Lobb Roy R; Dean Dennis C; Chang Linda L; Raab Conrad E; Si Qian; Hagmann William K; Lingham Russell B
Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.
Biochemistry 2002;41(22):7125-41.
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2002: Doherty George A; Yang Ginger X; Borges Edite; Chang Linda L; MacCoss Malcolm; Tong Sharon; Kidambi Usha; Egger Linda A; McCauley Ermenegilda; Van Riper Gail; Mumford Richard A; Schmidt John A; Hagmann William K
Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(11):1501-5.
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2002: Yang Ginger X; Chang Linda L; Truong Quang; Doherty George A; Magriotis Plato A; de Laszlo Stephen E; Li Bing; MacCoss Malcolm; Kidambi Usha; Egger Linda A; McCauley Ermengilda; Van Riper Gail; Mumford Richard A; Schmidt John A; Hagmann William K
N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(11):1497-500.
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2002: Doherty George A; Kamenecka Theodore; McCauley Ermenegilda; Van Riper Gail; Mumford Richard A; Tong Sharon; Hagmann William K
N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(5):729-31.
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2002: de Laszlo Stephen E; Li Bing; McCauley Ermengilda; Van Riper Gail; Hagmann William K
Identification of unique VLA-4 antagonists from a combinatorial library.
Bioorganic & medicinal chemistry letters 2002;12(4):685-8.
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2002: Kopka Ihor E; Young David N; Lin Linus S; Mumford Richard A; Magriotis Plato A; MacCoss Malcolm; Mills Sander G; Van Riper Gail; McCauley Ermengilda; Egger Linda E; Kidambi Usha; Schmidt John A; Lyons Kathryn; Stearns Ralph; Vincent Stella; Colletti Adria; Wang Zhen; Tong Sharon; Wang Junying; Zheng Song; Owens Karen; Levorse Dorothy; Hagmann William K
Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(4):637-40.
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2002: Lin Linus S; Kopka Ihor E; Mumford Richard A; Magriotis Plato A; Lanza Thomas; Durette Philippe L; Kamenecka Theodore; Young David N; de Laszlo Stephen E; McCauley Ermenegilda; Riper Gail Van; Kidambi Usha; Egger Linda A; Tong Xinchun; Lyons Kathryn; Vincent Stella; Stearns Ralph; Colletti Adria; Teffera Yohannes; Fenyk-Melody Judy; Schmidt John A; MacCoss Malcolm; Hagmann William K
The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(4):611-4.
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2002: Spence Stan; Vetter Christine; Hagmann William K; Van Riper Gail; Williams Hollis; Mumford Richard A; Lanza Thomas J; Lin Linus S; Schmidt John A
Effects of VLA-4 antagonists in rat whole embryo culture.
Teratology 2002;65(1):26-37.
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2002: Chang Linda L; Truong Quang; Mumford Richard A; Egger Linda A; Kidambi Usha; Lyons Kathryn; McCauley Ermengilda; Van Riper Gail; Vincent Stella; Schmidt John A; MacCoss Malcolm; Hagmann William K
The discovery of small molecule carbamates as potent dual alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.
Bioorganic & medicinal chemistry letters 2002;12(2):159-63.
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2002: Lin Linus S; Lanza Thomas; McCauley Ermenegilda; Van Riper Gail; Kidambi Usha; Cao Jin; Egger Linda A; Mumford Richard A; Schmidt John A; MacCoss Malcolm; Hagmann William K
Specific and dual antagonists of alpha(4)beta(1) and alpha(4)beta(7) integrins.
Bioorganic & medicinal chemistry letters 2002;12(2):133-6.
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2001: Chang L L; Sidler K L; Cascieri M A; de Laszlo S; Koch G; Li B; MacCoss M; Mantlo N; O'Keefe S; Pang M; Rolando A; Hagmann W K
Substituted imidazoles as glucagon receptor antagonists.
Bioorganic & medicinal chemistry letters 2001;11(18):2549-53.
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2000: Hagmann W K; Caldwell C G; Chen P; Durette P L; Esser C K; Lanza T J; Kopka I E; Guthikonda R; Shah S K; MacCoss M; Chabin R M; Fletcher D; Grant S K; Green B G; Humes J L; Kelly T M; Luell S; Meurer R; Moore V; Pacholok S G; Pavia T; Williams H R; Wong K K
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Bioorganic & medicinal chemistry letters 2000;10(17):1975-8.
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1999: de Laszlo S E; Hacker C; Li B; Kim D; MacCoss M; Mantlo N; Pivnichny J V; Colwell L; Koch G E; Cascieri M A; Hagmann W K
Potent, orally absorbed glucagon receptor antagonists.
Bioorganic & medicinal chemistry letters 1999;9(5):641-6.
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1999: Cascieri M A; Koch G E; Ber E; Sadowski S J; Louizides D; de Laszlo S E; Hacker C; Hagmann W K; MacCoss M; Chicchi G G; Vicario P P
Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor.
The Journal of biological chemistry 1999;274(13):8694-7.
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1997: Esser C K; Bugianesi R L; Caldwell C G; Chapman K T; Durette P L; Girotra N N; Kopka I E; Lanza T J; Levorse D A; MacCoss M; Owens K A; Ponpipom M M; Simeone J P; Harrison R K; Niedzwiecki L; Becker J W; Marcy A I; Axel M G; Christen A J; McDonnell J; Moore V L; Olszewski J M; Saphos C; Visco D M; Hagmann W K
Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
Journal of medicinal chemistry 1997;40(6):1026-40.
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1996: Gooley P R; O'Connell J F; Marcy A I; Cuca G C; Axel M G; Caldwell C G; Hagmann W K; Becker J W
Comparison of the structure of human recombinant short form stromelysin by multidimensional heteronuclear NMR and X-ray crystallography.
Journal of biomolecular NMR 1996;7(1):8-28.
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1996: Olszewski J M; Moore V L; McDonnell J; Williams H; Saphos C A; Green B G; Knight W B; Chapman K T; Hagmann W K; Dorn C P; Hale J J; Mumford R A
Proteoglycan-degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints. Quantitation of proteoglycan and a stromelysin-induced HABR fragment of aggrecan in synovial fluid and cartilage.
Connective tissue research 1996;33(4):291-9.
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1995: Bonassar L J; Jeffries K A; Frank E H; Moore V L; Lark M W; Bayne E K; McDonnell J; Olszewski J; Hagmann W; Chapman K
In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor.
Arthritis and rheumatism 1995;38(11):1678-86.
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1995: Becker J W; Marcy A I; Rokosz L L; Axel M G; Burbaum J J; Fitzgerald P M; Cameron P M; Esser C K; Hagmann W K; Hermes J D
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme.
Protein science : a publication of the Protein Society 1995;4(10):1966-76.
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1995: Bayne E K; MacNaul K L; Donatelli S A; Christen A; Griffin P R; Hoerrner L A; Calaycay J R; Ayala J M; Chapman K; Hagmann W
Use of an antibody against the matrix metalloproteinase-generated aggrecan neoepitope FVDIPEN-COOH to assess the effects of stromelysin in a rabbit model of cartilage degradation.
Arthritis and rheumatism 1995;38(10):1400-9.
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1994: Bonassar L J; Paguio C G; Frank E H; Jeffries K A; Moore V L; Lark M W; Caldwell C G; Hagmann W K; Grodzinsky A J
Effects of matrix metalloproteinases on cartilage biophysical properties in vitro and in vivo.
Annals of the New York Academy of Sciences 1994;732():439-43.
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1994: Izquierdo-Martin M; Chapman K T; Hagmann W K; Stein R L
Studies on the kinetic and chemical mechanism of inhibition of stromelysin by an N-(carboxyalkyl)dipeptide.
Biochemistry 1994;33(6):1356-65.
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1994: Gooley P R; O'Connell J F; Marcy A I; Cuca G C; Salowe S P; Bush B L; Hermes J D; Esser C K; Hagmann W K; Springer J P
The NMR structure of the inhibited catalytic domain of human stromelysin-1.
Nature structural biology 1994;1(2):111-8.
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1993: Gooley P R; Johnson B A; Marcy A I; Cuca G C; Salowe S P; Hagmann W K; Esser C K; Springer J P
Secondary structure and zinc ligation of human recombinant short-form stromelysin by multidimensional heteronuclear NMR.
Biochemistry 1993;32(48):13098-108.
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1993: Doherty J B; Shah S K; Finke P E; Dorn C P; Hagmann W K; Hale J J; Kissinger A L; Thompson K R; Brause K; Chandler G O
Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8727-31.
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1993: Chabin R; Green B G; Gale P; Maycock A L; Weston H; Dorn C P; Finke P E; Hagmann W K; Hale J J; MacCoss M
Mechanism of inhibition of human leucocyte elastase by monocyclic beta-lactams.
Biochemistry 1993;32(34):8970-80.
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1993: Hagmann W K; Kissinger A L; Shah S K; Finke P E; Dorn C P; Brause K A; Ashe B M; Weston H; Maycock A L; Knight W B
Orally active beta-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution.
Journal of medicinal chemistry 1993;36(6):771-7.
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1992: Shah S K; Dorn C P; Finke P E; Hale J J; Hagmann W K; Brause K A; Chandler G O; Kissinger A L; Ashe B M; Weston H
Orally active beta-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones.
Journal of medicinal chemistry 1992;35(21):3745-54.
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1992: Knight W B; Maycock A L; Green B G; Ashe B M; Gale P; Weston H; Finke P E; Hagmann W K; Shah S K; Doherty J B
Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives.
Biochemistry 1992;31(21):4980-6.
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1992: Salowe S P; Marcy A I; Cuca G C; Smith C K; Kopka I E; Hagmann W K; Hermes J D
Characterization of zinc-binding sites in human stromelysin-1: stoichiometry of the catalytic domain and identification of a cysteine ligand in the proenzyme.
Biochemistry 1992;31(19):4535-40.
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1992: Lanza T J; Durette P L; Rollins T; Siciliano S; Cianciarulo D N; Kobayashi S V; Caldwell C G; Springer M S; Hagmann W K
Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding.
Journal of medicinal chemistry 1992;35(2):252-8.
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1991: Marcy A I; Eiberger L L; Harrison R; Chan H K; Hutchinson N I; Hagmann W K; Cameron P M; Boulton D A; Hermes J D
Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form.
Biochemistry 1991;30(26):6476-83.
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1991: Green B G; Weston H; Ashe B M; Doherty J; Finke P; Hagmann W; Lark M; Mao J; Maycock A; Moore V
PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.
Archives of biochemistry and biophysics 1991;286(1):284-92.
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1990: Fletcher D S; Osinga D G; Hand K M; Dellea P S; Ashe B M; Mumford R A; Davies P; Hagmann W; Finke P E; Doherty J B
A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster.
The American review of respiratory disease 1990;141(3):672-7.
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1990: Egan R W; Hagmann W K; Gale P H
Naphthalenes as inhibitors of myeloperoxidase: direct and indirect mechanisms of inhibition.
Agents and actions 1990;29(3-4):266-76.
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1990: Ponpipom M M; Hagmann W K; O'Grady L A; Jackson J J; Wood D D; Zweerink H J
Glycolipids as host resistance stimulators.
Journal of medicinal chemistry 1990;33(2):861-7.
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1990: Hagmann W K; Ponpipom M M; Jackson J J; Wood D D; Boltz R C; Zweerink H J
Steroidal glycolipid, L-644,257, is a potent enhancer of nonspecific host resistance.
International journal of immunopharmacology 1990;12(2):241-6.
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1986: Hagmann W K; Dorn C P; Frankshun R A; O'Grady L A; Bailey P J; Rackham A; Dougherty H W
Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids.
Journal of medicinal chemistry 1986;29(8):1436-41.
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