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Sinuhe Hahn

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Kothandaraman Narasimhan; Ponnusamy Sukumar; Terry Tong; Sinuhe Hahn; Sherry Ho; Su Lin Lin; Sonia Baig; Vladimir B Bajic; Arijit Biswas; Mahesh Choolani
Maternal serum protein profile and immune response protein subunits as markers for non-invasive prenatal diagnosis of trisomy 21, 18, and 13.
Ines Kaufmann; Sinuhe Hahn; Irene Hösli; Corinne Rusterholz; Olav Lapaire
Can detection of late-onset PE at triage by sflt-1 or PlGF be improved by the use of additional biomarkers?
Sinuhe Hahn; Irene Hösli; Olav Lapaire
Non-invasive prenatal diagnostics using next generation sequencing: technical, legal and social challenges.

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2013: Kothandaraman Narasimhan; Ponnusamy Sukumar; Terry Tong; Sinuhe Hahn; Sherry Ho; Su Lin Lin; Sonia Baig; Vladimir B Bajic; Arijit Biswas; Mahesh Choolani
Maternal serum protein profile and immune response protein subunits as markers for non-invasive prenatal diagnosis of trisomy 21, 18, and 13.
Prenatal diagnosis 2013;33(3):223-31.
2012: Ines Kaufmann; Sinuhe Hahn; Irene Hösli; Corinne Rusterholz; Olav Lapaire
Can detection of late-onset PE at triage by sflt-1 or PlGF be improved by the use of additional biomarkers?
Prenatal diagnosis 2012;32(13):1288-94.
2012: Sinuhe Hahn; Irene Hösli; Olav Lapaire
Non-invasive prenatal diagnostics using next generation sequencing: technical, legal and social challenges.
Expert opinion on medical diagnostics 2012;6(6):517-28.
2012: Mahesh Choolani; Aniza P Mahyuddin; Sinuhe Hahn
The promise of fetal cells in maternal blood.
Best practice & research. Clinical obstetrics & gynaecology 2012;26(5):655-67.
2012: Sinuhe Hahn; Stavros Giaglis; Irene Hoesli; Paul Hasler
Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss.
Frontiers in immunology 2012;3():362.
2012: Varaprasad Kolla; Olav Lapaire; Suzette Moes; Irene Hoesli; Paul Jenö; Sinuhe Hahn
Quantitative proteomic (iTRAQ) analysis of 1st trimester maternal plasma samples in pregnancies at risk for preeclampsia.
Journal of biomedicine & biotechnology 2012;2012():305964.
2012: Olav Lapaire; Simon Grill; Irene Hösli; Varaprasad Kolla; Sebastien Lalevee; Sinuhe Hahn
Microarray screening for novel preeclampsia biomarker candidates.
Fetal diagnosis and therapy 2012;31(3):147-53.
2011: Monika Ostensen; Antonio Brucato; Howard Carp; Christina Chambers; Radboud J E M Dolhain; Andrea Doria; Frauke Förger; Caroline Gordon; Sinuhe Hahn; Munther Khamashta; Michael D Lockshin; Marco Matucci-Cerinic; Pierluigi Meroni; J Lee Nelson; Ann Parke; Michelle Petri; Luigi Raio; Guillermo Ruiz-Irastorza; Clovis A Silva; Angela Tincani; Peter M Villiger; Dorothea Wunder; Maurizio Cutolo
Pregnancy and reproduction in autoimmune rheumatic diseases.
Rheumatology (Oxford, England) 2011;50(4):657-64.
2011: Eva Visca; Irene Hösli; Olav Lapaire; Sinuhe Hahn
Cell-free fetal nucleic acids as prenatal biomarkers.
Expert opinion on medical diagnostics 2011;5(2):151-60.
2011: Sinuhe Hahn; Corinne Rusterholz; Irene Hösli; Olav Lapaire
Cell-free nucleic acids as potential markers for preeclampsia.
Placenta 2011;32 Suppl():S17-20.
2011: Sinuhe Hahn; Olav Lapaire; Sevgi Tercanli; Varaprasad Kolla; Irene Hösli
Determination of fetal chromosome aberrations from fetal DNA in maternal blood: has the challenge finally been met?
Expert reviews in molecular medicine 2011;13():e16.
2011: Corinne Rusterholz; Irene Hoesli; Marianne Messerli; Sinuhe Hahn
Placental microparticles, DNA, and RNA in preeclampsia.
Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy 2011;30(3):364-75.
2010: Sinuhe Hahn; Bernhard G Zimmermann
Cell-free DNA in maternal plasma: has the size-distribution puzzle been solved?
Clinical chemistry 2010;56(8):1210-1.
2010: Anurag Kumar Gupta; manjunath joshi; Maria Philippova; Paul Erne; Paul Hasler; Sinuhe Hahn; Therese J Resink
Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death.
FEBS letters 2010;584(14):3193-7.
2010: M Messerli; K May; S R Hansson; H Schneider; Wolfgang Holzgreve; Sinuhe Hahn; Corinne Rusterholz
Feto-maternal interactions in pregnancies: placental microparticles activate peripheral blood monocytes.
Placenta 2010;31(2):106-12.
2010: Sinuhe Hahn; Laird G Jackson; Bernhard G Zimmermann
Prenatal diagnosis of fetal aneuploidies: post-genomic developments.
Genome medicine 2010;2(8):50.
2010: S S Y Ho; Samuel S Chong; Evelyn S C Koay; Sukumar Ponnusamy; Lily Chiu; Yiong Huak Chan; Mary Rauff; Sonia Baig; Jerry Chan; Lin-Lin Su; Arijit Biswas; Sinuhe Hahn; Mahesh Choolani
Noninvasive prenatal exclusion of haemoglobin Bart's using foetal DNA from maternal plasma.
Prenatal diagnosis 2010;30(1):65-73.
2010: Varaprasad Kolla; Paul Jenö; Suzette Moes; Sevgi Tercanli; Olav Lapaire; Mahesh Choolani; Sinuhe Hahn
Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ).
Journal of biomedicine & biotechnology 2010;2010():952047.
2010: Aleksandra Sikora; Bernhard G Zimmermann; Corinne Rusterholz; Daniella Birri; Varaprasad Kolla; Olav Lapaire; Irene Hoesli; Vivian Kiefer; Laird Jackson; Sinuhe Hahn
Detection of increased amounts of cell-free fetal DNA with short PCR amplicons.
Clinical chemistry 2010;56(1):136-8.
2009: Ying Li; Gheona Altarescu; Paul Renbaum; Talia Eldar-Geva; Ephrat Levy-Lahad; Ehud J Margalioth; Xiaoyan Zhong; Sinuhe Hahn; Wolfgang Holzgreve
Non-invasive prenatal diagnosis using cell-free fetal DNA in maternal plasma from PGD pregnancies.
Reproductive biomedicine online 2009;19(5):714-20.
2009: Sinuhe Hahn; Laird G Jackson; Varaprasad Kolla; Aniza P Mahyuddin; Mahesh Choolani
Noninvasive prenatal diagnosis of fetal aneuploidies and Mendelian disorders: new innovative strategies.
Expert review of molecular diagnostics 2009;9(6):613-21.
2009: Alex Xiu-Cheng Fan; Ramin Radpour; Mahdi Montazer Haghighi; Corina Kohler; Peng Xia; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer.
Journal of cancer research and clinical oncology 2009;135(8):983-9.
2009: Simon Grill; Irina Banzola; Ying Li; Tea Rekhviashvili; Tobias J. Legler; Sina P Müller; Xiao Yan Zhong; Sinuhe Hahn; Wolfgang Holzgreve
High throughput non-invasive determination of foetal Rhesus D status using automated extraction of cell-free foetal DNA in maternal plasma and mass spectrometry.
Archives of gynecology and obstetrics 2009;279(4):533-7.
2009: Rebecca Zachariah; Seraina Schmid; Ramin Radpour; Nicole Buerki; Alex Xiu-Cheng Fan; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Circulating cell-free DNA as a potential biomarker for minimal and mild endometriosis.
Reproductive biomedicine online 2009;18(3):407-11.
2009: Mahesh Choolani; Kothandaraman Narasimhan; Varaprasad Kolla; Sinuhe Hahn
Proteomic technologies for prenatal diagnostics: advances and challenges ahead.
Expert review of proteomics 2009;6(1):87-101.
2009: Peng Xia; Ramin Radpour; Rebecca Zachariah; Alex Xiu Cheng Fan; Corina Kohler; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Simultaneous quantitative assessment of circulating cell-free mitochondrial and nuclear DNA by multiplex real-time PCR.
Genetics and molecular biology 2009;32(1):20-4.
2009: Simon Grill; Corinne Rusterholz; Rosanna Zanetti-Dällenbach; Sevgi Tercanli; Wolfgang Holzgreve; Sinuhe Hahn; Olav Lapaire
Potential markers of preeclampsia--a review.
Reproductive biology and endocrinology : RB&E 2009;7():70.
2009: Ying Li; Edoardo Di Naro; Angeloantonio Vitucci; Simon Grill; Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
Size fractionation of cell-free DNA in maternal plasma improves the detection of a paternally inherited beta-thalassemia point mutation by MALDI-TOF mass spectrometry.
Fetal diagnosis and therapy 2009;25(2):246-9.
2008: Bernhard Zimmermann; Simon Grill; Wolfgang Holzgreve; Xiao Yan Zhong; Laird G Jackson; Sinuhe Hahn
Digital PCR: a powerful new tool for noninvasive prenatal diagnosis?
Prenatal diagnosis 2008;28(12):1087-93.
2008: Ramin Radpour; Mahdi Montazer Haghighi; Alex Xiu-Cheng Fan; Peyman Mohammadi Torbati; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
High-throughput hacking of the methylation patterns in breast cancer by in vitro transcription and thymidine-specific cleavage mass array on MALDI-TOF silico-chip.
Molecular cancer research : MCR 2008;6(11):1702-9.
2008: Shereen El Tarhouny; Martin Seefeld; Alex Xiu-Cheng Fan; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Comparison of serum VEGF and its soluble receptor sVEGFR1 with serum cell-free DNA in patients with breast tumor.
Cytokine 2008;44(1):65-9.
2008: M Seefeld; S El Tarhouny; A X C Fan; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Parallel assessment of circulatory cell-free DNA by PCR and nucleosomes by ELISA in breast tumors.
The International journal of biological markers 2008;23(2):69-73.
2008: Sinuhe Hahn; Lyn S Chitty
Noninvasive prenatal diagnosis: current practice and future perspectives.
Current opinion in obstetrics & gynecology 2008;20(2):146-51.
2008: C Ellen van der Schoot; Sinuhe Hahn; Lyn S Chitty
Non-invasive prenatal diagnosis and determination of fetal Rh status.
Seminars in fetal & neonatal medicine 2008;13(2):63-8.
2008: Sinuhe Hahn; Lyn S Chitty
Non-invasive prenatal diagnosis: implications for antenatal diagnosis and the management of high-risk pregnancies.
Seminars in fetal & neonatal medicine 2008;13(2):55-6.
2008: Sinuhe Hahn; Xiao Yan Zhong; Wolfgang Holzgreve
Recent progress in non-invasive prenatal diagnosis.
Seminars in fetal & neonatal medicine 2008;13(2):57-62.
2008: Rosanna Zanetti-Dällenbach; Edward Wight; Alex Xiu-Cheng Fan; Olav Lapaire; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Positive correlation of cell-free DNA in plasma/serum in patients with malignant and benign breast disease.
Anticancer research 2008;28(2A):921-5.
2008: Ying Li; Kirstin Finning; Geoff Daniels; Sinuhe Hahn; Xiaoyan Zhong; Wolfgang Holzgreve
Noninvasive genotyping fetal Kell blood group (KEL1) using cell-free fetal DNA in maternal plasma by MALDI-TOF mass spectrometry.
Prenatal diagnosis 2008;28(3):203-8.
2008: Lyn S Chitty; C Ellen van der Schoot; Sinuhe Hahn; Neil D Avent
SAFE--the Special Non-invasive Advances in Fetal and Neonatal Evaluation Network: aims and achievements.
Prenatal diagnosis 2008;28(2):83-8.
2008: Anurag Kumar Gupta; Wolfgang Holzgreve; Sinuhe Hahn
Decrease in lipid levels of syncytiotrophoblast micro-particles reduced their potential to inhibit endothelial cell proliferation.
Archives of gynecology and obstetrics 2008;277(2):115-9.
2008: Chinnapapagari Satheesh Kumar Reddy; Wolfgang Holzgreve; Sinuhe Hahn
Detection of new screening markers for fetal aneuploidies in maternal plasma: a proteomic approach.
Methods in molecular biology (Clifton, N.J.) 2008;444():311-26.
2008: Ying Li; Wolfgang Holzgreve; Sinuhe Hahn
Size fractionation of cell-free DNA in maternal plasma and its application in noninvasive detection of fetal single gene point mutations.
Methods in molecular biology (Clifton, N.J.) 2008;444():239-51.
2008: Dorothy J Huang; Susanne Mergenthaler-Gatfield; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Isolation of cell-free DNA from maternal plasma using manual and automated systems.
Methods in molecular biology (Clifton, N.J.) 2008;444():203-8.
2008: Susanne Mergenthaler-Gatfield; Wolfgang Holzgreve; Sinuhe Hahn
Spectral karyotyping (SKY): applications in prenatal diagnostics.
Methods in molecular biology (Clifton, N.J.) 2008;444():3-26.
2008: Alex Xiu-Cheng Fan; Henk Garritsen; Shereen El Tarhouny; Michael Morris; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
A rapid and accurate approach to identify single nucleotide polymorphisms of mitochondrial DNA using MALDI-TOF mass spectrometry.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(3):299-305.
2007: Olav Lapaire; Thorsten Volgmann; Dorothy Huang; Sinuhe Hahn; Wolfgang Holzgreve; Xiao Yan Zhong
Maternal smoking: effect on circulating cell-free fetal and total DNA levels in maternal plasma from the second trimester.
Obstetrics and gynecology 2007;110(6):1358-63.
2007: Sashka Hristoskova; Wolfgang Holzgreve; Sinuhe Hahn; Corinne Rusterholz
The chromatin of differentiating erythroblasts is cleaved into large size fragments independent of caspase activated DNase and apoptosis inducing factor.
Journal of cellular physiology 2007;213(2):490-4.
2007: Xiao Yan Zhong; Ariane Ladewig; Seraina Schmid; Edward Wight; Sinuhe Hahn; Wolfgang Holzgreve
Elevated level of cell-free plasma DNA is associated with breast cancer.
Archives of gynecology and obstetrics 2007;276(4):327-31.
2007: Xiao Yan Zhong; Ines von Mühlenen; Ying Li; Anjeung Kang; Anurag Kumar Gupta; Alan Tyndall; Wolfgang Holzgreve; Sinuhe Hahn; Paul Hasler
Increased concentrations of antibody-bound circulatory cell-free DNA in rheumatoid arthritis.
Clinical chemistry 2007;53(9):1609-14.
2007: Xiao Yan Zhong; Sinuhe Hahn; Andrea Steinborn; Wolfgang Holzgreve
Quantitative analysis of intact fetal cells in maternal plasma by real-time PCR.
European journal of obstetrics, gynecology, and reproductive biology 2007;133(1):20-4.
2007: Sinuhe Hahn; XiaoYan Zhong; Wolfgang Holzgreve
Non-invasive prenatal diagnosis of Down's syndrome.
Lancet 2007;369(9578):1997-8; author reply 1998-9.
2007: Anurag Kumar Gupta; Paul Hasler; Wolfgang Holzgreve; Sinuhe Hahn
Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?
Seminars in immunopathology 2007;29(2):163-7.
2007: Corinne Rusterholz; Sinuhe Hahn; Wolfgang Holzgreve
Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia.
Seminars in immunopathology 2007;29(2):151-62.
2007: Rosanna Zanetti-Dällenbach; S Schmid; Edward Wight; Wolfgang Holzgreve; A Ladewing; Sinuhe Hahn; Xiao Yan Zhong
Levels of circulating cell-free serum DNA in benign and malignant breast lesions.
The International journal of biological markers 2007;22(2):95-9.
2007: Wolfgang Holzgreve; Sinuhe Hahn; Xiao Yan Zhong; Olav Lapaire; Irene Hösli; Sevgi Tercanli; Peter Mindy
Genetic communication between fetus and mother: short- and long-term consequences.
American journal of obstetrics and gynecology 2007;196(4):372-81.
2007: Sashka Hristoskova; Wolfgang Holzgreve; Sinuhe Hahn; Corinne Rusterholz
Human mature erythroblasts are resistant to apoptosis.
Experimental cell research 2007;313(5):1024-32.
2007: Carolyn Troeger; Daniel V Surbek; Andreina Schöberlein; Stephan Schatt; Lisbeth Dudler; Sinuhe Hahn; Wolfgang Holzgreve
In utero haematopoietic stem cell transplantation. Experiences in mice, sheep and humans.
Swiss medical weekly 2007;137 Suppl 155():14S-19S.
2007: Xiao Yan Zhong; Sinuhe Hahn; Vivian Kiefer; Wolfgang Holzgreve
Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender, age and frequency of blood donations?
Annals of hematology 2007;86(2):139-43.
2007: Bernhard Zimmermann; Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
Real-time quantitative polymerase chain reaction measurement of male fetal DNA in maternal plasma.
Methods in molecular medicine 2007;132():43-9.
2007: Olav Lapaire; Irene Hösli; Rosanna Zanetti-Daellenbach; Dorothy Huang; Carmen Jaeggi; Susanne Gatfield-Mergenthaler; Sinuhe Hahn; Wolfgang Holzgreve
Impact of fetal-maternal microchimerism on women's health--a review.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2007;20(1):1-5.
2007: Corinne Rusterholz; Wolfgang Holzgreve; Sinuhe Hahn
Oxidative stress alters the integrity of cell-free mRNA fragments associated with placenta-derived syncytiotrophoblast microparticles.
Fetal diagnosis and therapy 2007;22(4):313-7.
2007: Ying Li; Godelieve C M L Page-Christiaens; Johan J P Gille; Wolfgang Holzgreve; Sinuhe Hahn
Non-invasive prenatal detection of achondroplasia in size-fractionated cell-free DNA by MALDI-TOF MS assay.
Prenatal diagnosis 2007;27(1):11-7.
2006: Ying Li; Sinuhe Hahn; Wolfgang Holzgreve
Recent developments in the detection of fetal single gene differences in maternal plasma and the role of size fractionation.
Annals of the New York Academy of Sciences 2006;1092():285-92.
2006: Xiao Yan Zhong; Andrea Steinborn; Christof Sohn; Wolfgang Holzgreve; Sinuhe Hahn
High levels of circulatory erythroblasts and cell-free DNA prior to intrauterine fetal death.
Prenatal diagnosis 2006;26(13):1272-3.
2006: Claude Henri Diesch; Wolfgang Holzgreve; Sinuhe Hahn; Xiao Yan Zhong
Comparison of activin A and cell-free fetal DNA levels in maternal plasma from patients at high risk for preeclampsia.
Prenatal diagnosis 2006;26(13):1267-70.
2006: Ying Li; Wolfgang Holzgreve; Vivian Kiefer; Sinuhe Hahn
Maldi-tof mass spectrometry compared with real-time PCR for detection of fetal cell-free DNA in maternal plasma.
Clinical chemistry 2006;52(12):2311-2.
2006: Dorothy J Huang; Matthew Nelson; Bernhard Zimmermann; Lech Dudarewicz; Friedel Wenzel; Roland Spiegel; Balint Nagy; Wolfgang Holzgreve; Sinuhe Hahn
Reliable detection of trisomy 21 using MALDI-TOF mass spectrometry.
Genetics in medicine : official journal of the American College of Medical Genetics 2006;8(11):728-34.
2006: Ying Li; Friedel Wenzel; Wolfgang Holzgreve; Sinuhe Hahn
Genotyping fetal paternally inherited SNPs by MALDI-TOF MS using cell-free fetal DNA in maternal plasma: influence of size fractionation.
Electrophoresis 2006;27(19):3889-96.
2006: Bernhard Zimmermann; Wolfgang Holzgreve; Neil Avent; Sinuhe Hahn
Optimized real-time quantitative PCR measurement of male fetal DNA in maternal plasma.
Annals of the New York Academy of Sciences 2006;1075():347-9.
2006: Dorothy J Huang; Bernhard Zimmermann; Wolfgang Holzgreve; Sinuhe Hahn
Improvement of methods for the isolation of cell-free fetal DNA from maternal plasma: comparison of a manual and an automated method.
Annals of the New York Academy of Sciences 2006;1075():308-12.
2006: Ying Li; Deirdré Hahn; Friedel Wenzel; Wolfgang Holzgreve; Sinuhe Hahn
Detection of SNPs in the plasma of pregnant women and in the urine of kidney transplant recipients by mass spectrometry.
Annals of the New York Academy of Sciences 2006;1075():144-7.
2006: Anurag Gupta; Paul Hasler; Stefan Gebhardt; Wolfgang Holzgreve; Sinuhe Hahn
Occurrence of neutrophil extracellular DNA traps (NETs) in pre-eclampsia: a link with elevated levels of cell-free DNA?
Annals of the New York Academy of Sciences 2006;1075():118-22.
2006: Ying Li; Wolfgang Holzgreve; Edoardo Di Naro; Angeloantonio Vitucci; Sinuhe Hahn
Cell-free DNA in maternal plasma: is it all a question of size?
Annals of the New York Academy of Sciences 2006;1075():81-7.
2006: Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
Direct quantification of fetal cells in maternal blood by real-time PCR.
Prenatal diagnosis 2006;26(9):850-4.
2006: Carolyn Troeger; Daniel V Surbek; Andreina Schöberlein; Stephan Schatt; Lisbeth Dudler; Sinuhe Hahn; Wolfgang Holzgreve
In utero haematopoietic stem cell transplantation. Experiences in mice, sheep and humans.
Swiss medical weekly 2006;136(31-32):498-503.
2006: Sinuhe Hahn; Anurag Kumar Gupta; Carolyn Troeger; Corinne Rusterholz; Wolfgang Holzgreve
Disturbances in placental immunology: ready for therapeutic interventions?
Springer seminars in immunopathology 2006;27(4):477-93.
2006: Sashka Hristoskova; Wolfgang Holzgreve; Xiao Yan Zhong; Sinuhe Hahn
Macrophage migration inhibition factor is elevated in pregnancy, but not to a greater extent in preeclampsia.
Archives of gynecology and obstetrics 2006;274(1):25-8.
2006: Bernhard Zimmermann; Lisa Levett; Wolfgang Holzgreve; Sinuhe Hahn
Use of real-time polymerase chain reaction for the detection of fetal aneuploidies.
Methods in molecular biology (Clifton, N.J.) 2006;336():83-100.
2006: Xiao Yan Zhong; Wolfgang Holzgreve; Stefan Gebhardt; Renate Hillermann; Kashefa Carelse Tofa; Anurag Kumar Gupta; Berthold Huppertz; Sinuhe Hahn
Minimal alteration in the ratio of circulatory fetal DNA to fetal corticotropin-releasing hormone mRNA level in preeclampsia.
Fetal diagnosis and therapy 2006;21(3):246-9.
2006: Carolyn Troeger; Wolfgang Holzgreve; Ariane Ladewig; Xiao Yan Zhong; Sinuhe Hahn
Examination of maternal plasma erythropoietin and activin A concentrations with regard to circulatory erythroblast levels in normal and preeclamptic pregnancies.
Fetal diagnosis and therapy 2006;21(1):156-60.
2006: Anurag Kumar Gupta; Stefan Gebhardt; Renate Hillermann; Wolfgang Holzgreve; Sinuhe Hahn
Analysis of plasma elastase levels in early and late onset preeclampsia.
Archives of gynecology and obstetrics 2006;273(4):239-42.
2006: Xiao Yan Zhong; Wolfgang Holzgreve; Sevgi Tercanli; Friedel Wenzel; Sinuhe Hahn
Cell-free foetal DNA in maternal plasma does not appear to be derived from the rich pool of cell-free foetal DNA in amniotic fluid.
Archives of gynecology and obstetrics 2006;273(4):221-6.
2005: Dorothy J Huang; Bernhard Zimmermann; Wolfgang Holzgreve; Sinuhe Hahn
Use of an automated method improves the yield and quality of cell-free fetal DNA extracted from maternal plasma.
Clinical chemistry 2005;51(12):2419-20.
2005: Anurag Kumar Gupta; Corinne Rusterholz; Wolfgang Holzgreve; Sinuhe Hahn
Syncytiotrophoblast micro-particles do not induce apoptosis in peripheral T lymphocytes, but differ in their activity depending on the mode of preparation.
Journal of reproductive immunology 2005;68(1-2):15-26.
2005: Tatiana Babochkina; Susanne Mergenthaler; Tatyana Maier Dinges; Wolfgang Holzgreve; Sinuhe Hahn
Direct detection of fetal cells in maternal blood: a reappraisal using a combination of two different Y chromosome-specific FISH probes and a single X chromosome-specific probe.
Archives of gynecology and obstetrics 2005;273(3):166-9.
2005: Anurag Kumar Gupta; Paul Hasler; Wolfgang Holzgreve; Stefan Gebhardt; Sinuhe Hahn
Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia.
Human immunology 2005;66(11):1146-54.
2005: Rossa W K Chiu; Carol W M Chan; Xiao Yan Zhong; Olav Lapaire; Wolfgang Holzgreve; Sinuhe Hahn; Y M Dennis Lo
Fetal rhesus D mRNA is not detectable in maternal plasma.
Clinical chemistry 2005;51(11):2210-1.
2005: Ying Li; Deirdré Hahn; Wolfgang Holzgreve; Sinuhe Hahn
Ready detection of donor-specific single-nucleotide polymorphisms in the urine of renal transplant recipients by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Clinical chemistry 2005;51(10):1903-4.
2005: Sinuhe Hahn; Susanne Mergenthaler; Bernhard Zimmermann; Wolfgang Holzgreve
Nucleic acid based biosensors: the desires of the user.
Bioelectrochemistry (Amsterdam, Netherlands) 2005;67(2):151-4.
2005: Anurag Kumar Gupta; Wolfgang Holzgreve; Sinuhe Hahn
Microparticle-free placentally derived soluble factors downmodulate the response of activated T cells.
Human immunology 2005;66(9):977-84.
2005: Xiao Yan Zhong; Stefan Gebhardt; Renate Hillermann; Kashefa Carelse Tofa; Wolfgang Holzgreve; Sinuhe Hahn
Parallel assessment of circulatory fetal DNA and corticotropin-releasing hormone mRNA in early- and late-onset preeclampsia.
Clinical chemistry 2005;51(9):1730-3.
2005: Bernhard Zimmermann; Ahmad El-Sheikhah; Kypros Nicolaides; Wolfgang Holzgreve; Sinuhe Hahn
Optimized real-time quantitative PCR measurement of male fetal DNA in maternal plasma.
Clinical chemistry 2005;51(9):1598-604.
2005: Xiao Yan Zhong; Stefan Gebhardt; Renate Hillermann; Kashefa Carelse Tofa; Wolfgang Holzgreve; Sinuhe Hahn
Circulatory nucleosome levels are significantly increased in early and late-onset preeclampsia.
Prenatal diagnosis 2005;25(8):700-3.
2005: Sinuhe Hahn; Berthold Huppertz; Wolfgang Holzgreve
Fetal cells and cell free fetal nucleic acids in maternal blood: new tools to study abnormal placentation?
Placenta 2005;26(7):515-26.
2005: Tatiana Babochkina; Susanne Mergenthaler; Giuseppina De Napoli; Sashka Hristoskova; Sevgi Tercanli; Wolfgang Holzgreve; Sinuhe Hahn
Numerous erythroblasts in maternal blood are impervious to fluorescent in situ hybridization analysis, a feature related to a dense compact nucleus with apoptotic character.
Haematologica 2005;90(6):740-5.
2005: A Kumar Gupta; Corinne Rusterholz; Wolfgang Holzgreve; Sinuhe Hahn
Constant IFNgamma mRNA to protein ratios in cord and adult blood T cells suggests regulation of IFNgamma expression in cord blood T cells occurs at the transcriptional level.
Clinical and experimental immunology 2005;140(2):282-8.
2005: Andreina Schoeberlein; Wolfgang Holzgreve; Lisbeth Dudler; Sinuhe Hahn; Daniel V Surbek
Tissue-specific engraftment after in utero transplantation of allogeneic mesenchymal stem cells into sheep fetuses.
American journal of obstetrics and gynecology 2005;192(4):1044-52.
2005: Tatiana Babochkina; Susanne Mergenthaler; Olaf Lapaire; Vivian Kiefer; Hirofumi Yura; Kimie Koike; Wolfgang Holzgreve; Sinuhe Hahn
Evaluation of a soybean lectin-based method for the enrichment of erythroblasts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(3):329-30.
2005: Susanne Mergenthaler; Tatiana Babochkina; Vivian Kiefer; Olaf Lapaire; Wolfgang Holzgreve; Sinuhe Hahn
FISH analysis of all fetal nucleated cells in maternal whole blood: improved specificity by the use of two Y-chromosome probes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(3):319-22.
2005: Satheesh Kumar Reddy Chinnapapagari; Wolfgang Holzgreve; Olav Lapaire; Bernhard Zimmermann; Sinuhe Hahn
Treatment of maternal blood samples with formaldehyde does not alter the proportion of circulatory fetal nucleic acids (DNA and mRNA) in maternal plasma.
Clinical chemistry 2005;51(3):652-5.
2005: Xiao Yan Zhong; Wolfgang Holzgreve; Irene Hoesli; Sinuhe Hahn
Circulatory corticotropin-releasing hormone mRNA concentrations are increased in women with preterm delivery but not in those who respond to tocolytic treatment.
Clinical chemistry 2005;51(3):635-6.
2005: Ying Li; Edoardo Di Naro; Angeloantonio Vitucci; Bernhard Zimmermann; Wolfgang Holzgreve; Sinuhe Hahn
Detection of paternally inherited fetal point mutations for beta-thalassemia using size-fractionated cell-free DNA in maternal plasma.
JAMA : the journal of the American Medical Association 2005;293(7):843-9.
2005: Corinne Rusterholz; Anurag K Gupta; Berthold Huppertz; Wolfgang Holzgreve; Sinuhe Hahn
Soluble factors released by placental villous tissue: Interleukin-1 is a potential mediator of endothelial dysfunction.
American journal of obstetrics and gynecology 2005;192(2):618-24.
2005: Anurag Kumar Gupta; Corinne Rusterholz; Berthold Huppertz; A Malek; H Schneider; Wolfgang Holzgreve; Sinuhe Hahn
A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells.
Placenta 2005;26(1):59-66.
2004: Andreina Schoeberlein; Stephan Schatt; Carolyn Troeger; Daniel V Surbek; Wolfgang Holzgreve; Sinuhe Hahn
Engraftment kinetics of human cord blood and murine fetal liver stem cells following in utero transplantation into immunodeficient mice.
Stem cells and development 2004;13(6):677-84.
2004: Xiao Yan Zhong; Yiming Wang; Suqin Chen; Xiaoying Pan; Ninghu Zhu; Cornelia Hahn; Berthold Huppertz; Wolfgang Holzgreve; Sinuhe Hahn
Circulating fetal DNA in maternal plasma is increased in pregnancies at high altitude and is further enhanced by preeclampsia.
Clinical chemistry 2004;50(12):2403-5.
2004: Ying Li; Wolfgang Holzgreve; Godelieve C M L Page-Christiaens; Johan J P Gille; Sinuhe Hahn
Improved prenatal detection of a fetal point mutation for achondroplasia by the use of size-fractionated circulatory DNA in maternal plasma--case report.
Prenatal diagnosis 2004;24(11):896-8.
2004: Anurag Kumar Gupta; Wolfgang Holzgreve; Berthold Huppertz; Antoine Malek; Henning Schneider; Sinuhe Hahn
Detection of fetal DNA and RNA in placenta-derived syncytiotrophoblast microparticles generated in vitro.
Clinical chemistry 2004;50(11):2187-90.
2004: Andreina Schoeberlein; Wolfgang Holzgreve; Lisbeth Dudler; Sinuhe Hahn; Daniel V Surbek
In utero transplantation of autologous and allogeneic fetal liver stem cells in ovine fetuses.
American journal of obstetrics and gynecology 2004;191(3):1030-6.
2004: Xiao Yan Zhong; Yiming Wang; Suqin Chen; Cornelia Hahn; Wolfgang Holzgreve; Sinuhe Hahn
Can circulatory fetal DNA be used to study placentation at high altitude?
Annals of the New York Academy of Sciences 2004;1022():124-8.
2004: Ying Li; Bernhard Zimmermann; Corinne Rusterholz; Anjeung Kang; Wolfgang Holzgreve; Sinuhe Hahn
Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms.
Clinical chemistry 2004;50(6):1002-11.
2004: Kirby L Johnson; Kim Dukes; John Vidaver; Erik S LeShane; Idania Ramirez; William D Weber; Farideh Z Bischoff; Sinuhe Hahn; Arun Sharma; Dianne X Dang; Lisa M Hire; Diana Bianchi; Joe Simpson; Wolfgang Holzgreve; Sherman Elias; Katherine W Klinger
Interlaboratory comparison of fetal male DNA detection from common maternal plasma samples by real-time PCR.
Clinical chemistry 2004;50(3):516-21.
2004: Sashka Hristoskova; Wolfgang Holzgreve; Sinuhe Hahn
Anti-phospholipid and anti-DNA antibodies are not associated with the elevated release of circulatory fetal DNA in pregnancies affected by preeclampsia.
Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy 2004;23(3):257-68.
2003: Ying Li; Xiao Yan Zhong; Anjeung Kang; Carolyn Troeger; Wolfgang Holzgreve; Sinuhe Hahn
Inability to detect cell free fetal DNA in the urine of normal pregnant women nor in those affected by preeclampsia associated HELLP syndrome.
Journal of the Society for Gynecologic Investigation 2003;10(8):503-8.
2003: Sashka Hristoskova; Wolfgang Holzgreve; Sinuhe Hahn
Fetal nucleated erythrocytes in maternal circulation do not display a classic membrane-associated apoptotic characteristic (phosphatidylserine exposure) despite being positive by terminal dUTP nuclear end labeling.
Clinical chemistry 2003;49(11):1934-7.
2003: Y Li; Bernhard Zimmermann; Xiao Yan Zhong; A K Gupta; Wolfgang Holzgreve; Sinuhe Hahn
Determination of RHD zygosity using real-time quantitative PCR.
Swiss medical weekly 2003;133(31-32):442-5.
2003: Ying Li; Deirdré Hahn; Xiao Yan Zhong; Peter D Thomson; Wolfgang Holzgreve; Sinuhe Hahn
Detection of donor-specific DNA polymorphisms in the urine of renal transplant recipients.
Clinical chemistry 2003;49(4):655-8.
2003: Farideh Z Bischoff; Sinuhe Hahn; Kirby L Johnson; Joe Simpson; Diana Bianchi; Dorothy E Lewis; William D Weber; Katherine W Klinger; Sherman Elias; Laird G Jackson; Mark I Evans; Wolfgang Holzgreve; Felix de la Cruz
Intact fetal cells in maternal plasma: are they really there?
Lancet 2003;361(9352):139-40.
2002: Sinuhe Hahn; Wolfgang Holzgreve
Fetal cells and cell-free fetal DNA in maternal blood: new insights into pre-eclampsia.
Human reproduction update 2002;8(6):501-8.
2002: Irene Hoesli; Milan Danek; Dexin Lin; Ying Li; Sinuhe Hahn; Wolfgang Holzgreve
Circulating erythroblasts in maternal blood are not elevated before onset of preterm labor.
Obstetrics and gynecology 2002;100(5 Pt 1):992-6.
2002: Sinuhe Hahn; Wolfgang Holzgreve
Prenatal diagnosis using fetal cells and cell-free fetal DNA in maternal blood: what is currently feasible?
Clinical obstetrics and gynecology 2002;45(3):649-56; discussion 730-2.
2002: Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts.
Molecular human reproduction 2002;8(9):864-70.
2002: Bernhard Zimmermann; Wolfgang Holzgreve; Friedel Wenzel; Sinuhe Hahn
Novel real-time quantitative PCR test for trisomy 21.
Clinical chemistry 2002;48(2):362-3.
2002: Sinuhe Hahn; Xiao Yan Zhong; Wolfgang Holzgreve
Single cell PCR in laser capture microscopy.
Methods in enzymology 2002;356():295-301.
2002: Wolfang Holzgreve; Sinuhe Hahn
[Non-invasive prenatal diagnosis--already a reality?].
Gynäkologisch-geburtshilfliche Rundschau 2002;42(2):84-6.
2002: Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia.
Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy 2002;21(1):77-83.
2001: Xiao Yan Zhong; D Hahn; Carolyn Troeger; A Klemm; G Stein; P Thomson; Wolfgang Holzgreve; Sinuhe Hahn
Cell-free DNA in urine: a marker for kidney graft rejection, but not for prenatal diagnosis?
Annals of the New York Academy of Sciences 2001;945():250-7.
2001: Sinuhe Hahn; Xiao Yan Zhong; MR Bürk; Carolyn Troeger; Anjeung Kang; Wolfgang Holzgreve
Both maternal and fetal cell-free DNA in plasma fluctuate.
Annals of the New York Academy of Sciences 2001;945():141-4.
2001: Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
Circulatory fetal and maternal DNA in pregnancies at risk and those affected by preeclampsia.
Annals of the New York Academy of Sciences 2001;945():138-40.
2001: Daniel V Surbek; Enrico Danzer; C Steinmann; André Tichelli; Aleksandra Wodnar-Filipowicz; Sinuhe Hahn; Wolfgang Holzgreve
Effect of preeclampsia on umbilical cord blood hematopoietic progenitor-stem cells.
American journal of obstetrics and gynecology 2001;185(3):725-9.
2001: MR Bürk; Carolyn Troeger; R Brinkhaus; Wolfgang Holzgreve; Sinuhe Hahn
Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae.
Placenta 2001;22(4):309-16.
2001: Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
Risk free simultaneous prenatal identification of fetal Rhesus D status and sex by multiplex real-time PCR using cell free fetal DNA in maternal plasma.
Swiss medical weekly 2001;131(5-6):70-4.
2001: Xiao Yan Zhong; H Laivuori; J C Livingston; O Ylikorkala; B M Sibai; Wolfgang Holzgreve; Sinuhe Hahn
Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia.
American journal of obstetrics and gynecology 2001;184(3):414-9.
2001: Wolfgang Holzgreve; Xiao Yan Zhong; M R Burk; Sinuhe Hahn
Enrichment of fetal cells and free fetal DNA from maternal blood: An insight into the Basel experience.
Early pregnancy (Online) 2001;5(1):43-4.
2001: Wolfgang Holzgreve; J J Li; Andrea Steinborn; Thomas Külz; Christof Sohn; M Hodel; Sinuhe Hahn
Elevation in erythroblast count in maternal blood before the onset of preeclampsia.
American journal of obstetrics and gynecology 2001;184(2):165-8.
2000: Xiao Yan Zhong; MR Bürk; Carolyn Troeger; Anjeung Kang; Wolfgang Holzgreve; Sinuhe Hahn
Fluctuation of maternal and fetal free extracellular circulatory DNA in maternal plasma.
Obstetrics and gynecology 2000;96(6):991-6.
2000: Daniel V Surbek; C Steinmann; M Bürk; Sinuhe Hahn; André Tichelli; Wolfgang Holzgreve
Developmental changes in adhesion molecule expressions in umbilical cord blood CD34 hematopoietic progenitor and stem cells.
American journal of obstetrics and gynecology 2000;183(5):1152-7.
2000: Xiao Yan Zhong; Wolfgang Holzgreve; J C Li; K Aydinli; Sinuhe Hahn
High levels of fetal erythroblasts and fetal extracellular DNA in the peripheral blood of a pregnant woman with idiopathic polyhydramnios: case report.
Prenatal diagnosis 2000;20(10):838-41.
2000: Xiao Yan Zhong; MR Bürk; Carolyn Troeger; L R Jackson; Wolfgang Holzgreve; Sinuhe Hahn
Fetal DNA in maternal plasma is elevated in pregnancies with aneuploid fetuses.
Prenatal diagnosis 2000;20(10):795-8.
2000: Wolfgang Holzgreve; Sinuhe Hahn
Fetal cells in cervical mucus and maternal blood.
Baillière's best practice & research. Clinical obstetrics & gynaecology 2000;14(4):709-22.
2000: Daniel V Surbek; Wolfgang Holzgreve; C Steinmann; Sinuhe Hahn; Alois Gratwohl; Aleksandra Wodnar-Filipowicz; André Tichelli
Preterm birth and the availability of cord blood for HPC transplantation.
Transfusion 2000;40(7):817-20.
2000: Daniel V Surbek; Eva Visca; C Steinmann; André Tichelli; S Schatt; Sinuhe Hahn; Alois Gratwohl; Wolfgang Holzgreve
Umbilical cord blood collection before placental delivery during cesarean delivery increases cord blood volume and nucleated cell number available for transplantation.
American journal of obstetrics and gynecology 2000;183(1):218-21.
2000: Xiao Yan Zhong; Wolfgang Holzgreve; Sinuhe Hahn
Detection of fetal Rhesus D and sex using fetal DNA from maternal plasma by multiplex polymerase chain reaction.
BJOG : an international journal of obstetrics and gynaecology 2000;107(6):766-9.
2000: Edoardo Di Naro; Fabio Ghezzi; Angeloantonio Vitucci; Nunzia Tannoia; D Campanale; Vincenzo D'Addario; Wolfgang Holzgreve; Sinuhe Hahn
Prenatal diagnosis of beta-thalassaemia using fetal erythroblasts enriched from maternal blood by a novel gradient.
Molecular human reproduction 2000;6(6):571-4.
2000: G Smits; Wolfgang Holzgreve; Sinuhe Hahn
An examination of different Percoll density gradients and magnetic activated cell sorting (MACS) for the enrichment of fetal erythroblasts from maternal blood.
Archives of gynecology and obstetrics 2000;263(4):160-3.
2000: Sinuhe Hahn; Xiao Yan Zhong; MR Bürk; Carolyn Troeger; Wolfgang Holzgreve
Multiplex and real-time quantitative PCR on fetal DNA in maternal plasma. A comparison with fetal cells isolated from maternal blood.
Annals of the New York Academy of Sciences 2000;906():148-52.
2000: V Brombacher; Vivian Kiefer; Carolyn Troeger; Y Vial; S Minderer; Wolfgang Holzgreve; Sinuhe Hahn
Choice of anticoagulant can influence the analysis using fluorescence in situ hybridization of fetal cells enriched from maternal blood.
Prenatal diagnosis 2000;20(3):257-9.
2000: Sinuhe Hahn; Xiao Yan Zhong; Carolyn Troeger; R Burgemeister; K Gloning; Wolfgang Holzgreve
Current applications of single-cell PCR.
Cellular and molecular life sciences : CMLS 2000;57(1):96-105.
1999: Carolyn Troeger; Xiao Yan Zhong; R Burgemeister; S Minderer; Sevgi Tercanli; Wolfgang Holzgreve; Sinuhe Hahn
Approximately half of the erythroblasts in maternal blood are of fetal origin.
Molecular human reproduction 1999;5(12):1162-5.
1999: Sinuhe Hahn; Vivian Kiefer; V Brombacher; Carolyn Troeger; Wolfgang Holzgreve
Fetal cells in maternal blood. An update from Basel.
European journal of obstetrics, gynecology, and reproductive biology 1999;85(1):101-4.
1999: Carolyn Troeger; Wolfgang Holzgreve; Sinuhe Hahn
A comparison of different density gradients and antibodies for enrichment of fetal erythroblasts by MACS.
Prenatal diagnosis 1999;19(6):521-6.
1998: Wolfgang Holzgreve; Carolyn Troeger; Stephan Schatt; Y Vial; F Louwen; K Gloning; Sinuhe Hahn
[Prenatal diagnosis with fetal cells in maternal blood: report of experiences in Basal].
Schweizerische medizinische Wochenschrift 1998;128(43):1641-5.
1998: AM Garvin; Wolfgang Holzgreve; Sinuhe Hahn
Highly accurate analysis of heterozygous loci bysingle cell PCR.
Nucleic acids research 1998;26(15):3468-72.
1998: Wolfgang Holzgreve; Edoardo Di Naro; AM Garvin; Carolyn Troeger; Sinuhe Hahn
Prenatal diagnosis using fetal cells enriched from maternal blood.
Croatian medical journal 1998;39(2):115-20.
1998: Wolfgang Holzgreve; Fabio Ghezzi; Edoardo Di Naro; D Gänshirt; E Maymon; Sinuhe Hahn
Disturbed feto-maternal cell traffic in preeclampsia.
Obstetrics and gynecology 1998;91(5 Pt 1):669-72.
1998: Sinuhe Hahn; AM Garvin; Edoardo Di Naro; Wolfgang Holzgreve
Allele drop-out can occur in alleles differing by a single nucleotide and is not alleviated by preamplification or minor template increments.
Genetic testing 1998;2(4):351-5.