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Young Hahn

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TOP 3
Stephen Caldwell; Kyle L Hoehn; Young S Hahn
The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil.
Hai-Chon Lee; Hugo R Rosen; Sung-Sang J Sung; Steven F Ziegler; Yoon-Ah Jo; Peter D Krueger; Young S Hahn
Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes.
Joseph S Dolina; Tuyen M Nguyen; Tatiana I Novobrantseva; Sun-Sang J Sung; Young S Hahn
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.

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All Publications

2013: Stephen Caldwell; Kyle L Hoehn; Young S Hahn
The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil.
Hepatology (Baltimore, Md.) 2013;57(5):1684-7.
2013: Hai-Chon Lee; Hugo R Rosen; Sung-Sang J Sung; Steven F Ziegler; Yoon-Ah Jo; Peter D Krueger; Young S Hahn
Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes.
Hepatology (Baltimore, Md.) 2013;57(4):1314-24.
2013: Joseph S Dolina; Tuyen M Nguyen; Tatiana I Novobrantseva; Sun-Sang J Sung; Young S Hahn
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids 2013;2():e72.
2012: Robert S Tacke; Jeremy Courtney; Celeste Goh; Hai-Chon Lee; Stephen J Polyak; Hugo R Rosen; Young S Hahn
Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species.
Hepatology (Baltimore, Md.) 2012;55(2):343-53.
2011: Peter D Krueger; Matthew G Lassen; Huihong Qiao; Young S Hahn
Regulation of NK cell repertoire and function in the liver.
Critical reviews in immunology 2011;31(1):43-52.
2010: Matthew G Lassen; John R Lukens; Joseph S Dolina; Michael G Brown; Young S Hahn
Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2693-701.
2010: Caroline H T Hall; Rachel Kassel; Robert S Tacke; Young S Hahn
HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta.
PloS one 2010;5(8):e12154.
2009: Rachel Kassel; Michael W Cruise; Julia C Iezzoni; Nicholas A Taylor; Timothy L Pruett; Young S Hahn
Chronically inflamed livers up-regulate expression of inhibitory B7 family members.
Hepatology (Baltimore, Md.) 2009;50(5):1625-37.
2009: Kara L Cummings; Hugo R Rosen; Young S Hahn
Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection.
Clinical immunology (Orlando, Fla.) 2009;132(3):401-11.
2009: John R Lukens; Joseph S Dolina; Taeg S Kim; Robert S Tacke; Young S Hahn
Liver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system.
PloS one 2009;4(10):e7619.
2008: John R Lukens; Michael W Cruise; Matthew G Lassen; Young S Hahn
Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4875-84.
2007: Kara L Cummings; Stephen N Waggoner; Robert Tacke; Young S Hahn
Role of complement in immune regulation and its exploitation by virus.
Viral immunology 2007;20(4):505-24.
2007: Stephen N Waggoner; Caroline H T Hall; Young S Hahn
HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production.
Journal of leukocyte biology 2007;82(6):1407-19.
2006: Zhi Qiang Yao; Stephen N Waggoner; Michael W Cruise; Caroline Hall; Xuefang Xie; David W Oldach; Young S Hahn
SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function.
Journal of virology 2006;80(16):8287.
2006: Michael W Cruise; John R Lukens; Aileen P Nguyen; Matthew G Lassen; Stephen N Waggoner; Young S Hahn
Fas ligand is responsible for CXCR3 chemokine induction in CD4+ T cell-dependent liver damage.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6235-44.
2006: Zhi Qiang Yao; Mohamed Tarek Shata; Nancy Tricoche; Mei Mei Shan; Betsy Brotman; Wolfram Pfahler; Young S Hahn; Alfred M Prince
gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection.
Virology 2006;346(2):324-37.
2005: Zhi Qiang Yao; Stephen N Waggoner; Michael W Cruise; Caroline Hall; Xuefang Xie; David W Oldach; Young S Hahn
SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function.
Journal of virology 2005;79(24):15417-29.
2005: Stephen N Waggoner; Michael W Cruise; Rachel Kassel; Young S Hahn
gC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4706-14.
2005: Michael W Cruise; Hendrikje M Melief; John R Lukens; Carolina Soguero; Young S Hahn
Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell-dependent hepatic inflammation.
Journal of leukocyte biology 2005;78(2):412-25.
2005: Myungsoo Joo; Young S Hahn; Minjae Kwon; Ruxana T Sadikot; Timothy S Blackwell; John W Christman
Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.
Journal of virology 2005;79(12):7648-57.
2004: Audrey Eisen-Vandervelde; Stephen N Waggoner; Zhi Qiang Yao; Evan M Cale; Chang S Hahn; Young S Hahn
Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation.
The Journal of biological chemistry 2004;279(42):43479-86.
2004: Zhi Qiang Yao; Audrey Eisen-Vandervelde; Stephen N Waggoner; Evan M Cale; Young S Hahn
Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt.
Journal of virology 2004;78(12):6409-19.
2004: Audrey Eisen-Vandervelde; Zhi Qiang Yao; Young S Hahn
The molecular basis of HCV-mediated immune dysregulation.
Clinical immunology (Orlando, Fla.) 2004;111(1):16-21.
2003: Zhi Qiang Yao; Audrey Eisen-Vandervelde; Suma Ray; Young S Hahn
HCV core/gC1qR interaction arrests T cell cycle progression through stabilization of the cell cycle inhibitor p27Kip1.
Virology 2003;314(1):271-82.
2003: Jonathan P Moorman; Deborah Prayther; Derek McVay; Young S Hahn; Chang S Hahn
The C-terminal region of hepatitis C core protein is required for Fas-ligand independent apoptosis in Jurkat cells by facilitating Fas oligomerization.
Virology 2003;312(2):320-9.
2003: Young S Hahn
Subversion of immune responses by hepatitis C virus: immunomodulatory strategies beyond evasion?
Current opinion in immunology 2003;15(4):443-9.
2002: Carolina Soguero; Myungsoo Joo; Kimberly A Chianese-Bullock; Duong Tony Nguyen; Kenneth Tung; Young S Hahn
Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model.
Journal of virology 2002;76(18):9345-54.
2001: Zhi Qiang Yao; D T Nguyen; A I Hiotellis; Young S Hahn
Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5264-72.
2001: Zhi Qiang Yao; S Ray; Audrey Eisen-Vandervelde; Stephen N Waggoner; Young S Hahn
Hepatitis C virus: immunosuppression by complement regulatory pathway.
Viral immunology 2001;14(4):277-95.
2001: J P Moorman; Myungsoo Joo; Young S Hahn
Evasion of host immune surveillance by hepatitis C virus: potential roles in viral persistence.
Archivum immunologiae et therapiae experimentalis 2001;49(3):189-94.
2000: DJ Kittlesen; Kimberly A Chianese-Bullock; Zhi Qiang Yao; Thomas J Braciale; Young S Hahn
Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation.
The Journal of clinical investigation 2000;106(10):1239-49.
2000: Chang S Hahn; Young-Gyu Cho; BS Kang; I M Lester; Young S Hahn
The HCV core protein acts as a positive regulator of fas-mediated apoptosis in a human lymphoblastoid T cell line.
Virology 2000;276(1):127-37.
2000: Min Q Zhao; MH Stoler; AN Liu; B Wei; Carolina Soguero; Young S Hahn; Richard I Enelow
Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8(+) T cell recognition.
The Journal of clinical investigation 2000;106(6):R49-58.
2000: Myungsoo Joo; Young S Hahn
Animal models for immune defects caused by hepatitis C virus.
Molecular medicine today 2000;6(4):176-7.
1999: M K Large; DJ Kittlesen; Young S Hahn
Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):931-8.
1999: Young S Hahn; A Guanzon; C M Rice; Chang S Hahn
Class I MHC molecule-mediated inhibition of Sindbis virus replication.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):69-77.
1996: Young S Hahn; Chang S Hahn; Thomas J Braciale
Endogenous presentation of a nascent antigenic epitope to CD8+ CTL is more efficient than exogenous presentation.
Immunology and cell biology 1996;74(5):394-400.
1996: B Yang; Young S Hahn; Chang S Hahn; Thomas J Braciale
The requirement for proteasome activity class I major histocompatibility complex antigen presentation is dictated by the length of preprocessed antigen.
The Journal of experimental medicine 1996;183(4):1545-52.
1992: Young S Hahn; Chang S Hahn; Vivian L Braciale; Thomas J Braciale; Charles M Rice
CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.
The Journal of experimental medicine 1992;176(5):1335-41.
1992: Chang S Hahn; Young S Hahn; Thomas J Braciale; Charles M Rice
Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2679-83.
1991: Young S Hahn; Vivian L Braciale; Thomas J Braciale
Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.
The Journal of experimental medicine 1991;174(3):733-6.
1990: W R Hardy; Young S Hahn; R J de Groot; Ellen G Strauss; James H Strauss
Synthesis and processing of the nonstructural polyproteins of several temperature-sensitive mutants of Sindbis virus.
Virology 1990;177(1):199-208.
1990: Young S Hahn; E M Lenches; R Galler; Charles M Rice; J Dalrymple; James H Strauss
Expression of the structural proteins of dengue 2 virus and yellow fever virus by recombinant vaccinia viruses.
Archives of virology 1990;115(3-4):251-65.
1989: Young S Hahn; Ellen G Strauss; James H Strauss
Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins.
Journal of virology 1989;63(7):3142-50.
1989: Young S Hahn; Arash Grakoui; Charles M Rice; Ellen G Strauss; James H Strauss
Mapping of RNA- temperature-sensitive mutants of Sindbis virus: complementation group F mutants have lesions in nsP4.
Journal of virology 1989;63(3):1194-202.
1988: Young S Hahn; R Galler; T Hunkapiller; J M Dalrymple; James H Strauss; Ellen G Strauss
Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses.
Virology 1988;162(1):167-80.
1987: Chang S Hahn; Young S Hahn; Charles M Rice; E Lee; L Dalgarno; Ellen G Strauss; James H Strauss
Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences.
Journal of molecular biology 1987;198(1):33-41.