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Juha Hakala

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Streptomyces

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TOP 3
Anne Hautala; Sirke Torkkell; Kaj Räty; Tero Kunnari; Jaana Kantola; Pekka Mantsälä; Juha Hakala; Kristiina Ylihonko
Studies on a second and third ring cyclization in anthracycline biosynthesis.
Kaj Räty; Anne Hautala; Sirke Torkkell; Jaana Kantola; Pekka Mäntsälä; Juha Hakala; Kristiina Ylihonko
Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns.
Mikko Metsä-Ketelä; Laura Halo; Eveliina Munukka; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species.

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All Publications

2003: Anne Hautala; Sirke Torkkell; Kaj Räty; Tero Kunnari; Jaana Kantola; Pekka Mantsälä; Juha Hakala; Kristiina Ylihonko
Studies on a second and third ring cyclization in anthracycline biosynthesis.
The Journal of antibiotics 2003;56(2):143-53.
2002: Kaj Räty; Anne Hautala; Sirke Torkkell; Jaana Kantola; Pekka Mäntsälä; Juha Hakala; Kristiina Ylihonko
Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns.
Microbiology (Reading, England) 2002;148(Pt 11):3375-84.
2002: Mikko Metsä-Ketelä; Laura Halo; Eveliina Munukka; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species.
Applied and environmental microbiology 2002;68(9):4472-9.
2002: Kaj Räty; Jaana Kantola; Anne Hautala; Juha Hakala; Kristiina Ylihonko; Pekka Mäntsälä
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
Gene 2002;293(1-2):115-22.
2001: Sirke Torkkell; Tero Kunnari; Kaisa Palmu; Pekka Mäntsälä; Juha Hakala; Kristiina Ylihonko
The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.
Molecular genetics and genomics : MGG 2001;266(2):276-88.
2000: Kaj Räty; Tero Kunnari; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.
Molecular & general genetics : MGG 2000;264(1-2):164-72.
2000: Yulong Wang; Jarmo Niemi; Kalervo Airas; Kristiina Ylihonko; Juha Hakala; Pekka Mäntsälä
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
Biochimica et biophysica acta 2000;1480(1-2):191-200.
2000: Tero Kunnari; Kristiina Ylihonko; Karel D Klika; Pekka Mäntsälä; Juha Hakala
Hybrid anthracyclines from a genetically engineered Streptomyces galilaeus mutant.
The Journal of organic chemistry 2000;65(10):2851-5.
2000: Sirke Torkkell; Tero Kunnari; Kaisa Palmu; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.
Antimicrobial agents and chemotherapy 2000;44(2):396-9.
2000: Jaana Kantola; Tero Kunnari; Anne Hautala; Juha Hakala; Kristiina Ylihonko; Pekka Mäntsälä
Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
Microbiology (Reading, England) 2000;146 ( Pt 1)():155-63.
1999: Mikko Metsä-Ketelä; Virpi Salo-Zieman; L Halo; Anne Hautala; Juha Hakala; Pekka Mäntsälä; Kristiina Ylihonko
An efficient approach for screening minimal PKS genes from Streptomyces.
FEMS microbiology letters 1999;180(1):1-6.
1999: Tero Kunnari; Kristiina Ylihonko; Anne Hautala; K D Klika; Pekka Mäntsälä; Juha Hakala
Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.
Bioorganic & medicinal chemistry letters 1999;9(18):2639-42.
1999: Jarmo Niemi; Yulong Wang; Kalervo Airas; Kristiina Ylihonko; Juha Hakala; Pekka Mäntsälä
Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens.
Biochimica et biophysica acta 1999;1430(1):57-64.
1997: Jaana Kantola; G Blanco; Anne Hautala; Tero Kunnari; Juha Hakala; C Mendez; Kristiina Ylihonko; Pekka Mäntsälä; J Salas
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.
Chemistry & biology 1997;4(10):751-5.
1997: Sirke Torkkell; Kristiina Ylihonko; Juha Hakala; Mikael Skurnik; Pekka Mäntsälä
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.
Molecular & general genetics : MGG 1997;256(2):203-9.
1997: Tero Kunnari; J Tuikkanen; Anne Hautala; Juha Hakala; Kristiina Ylihonko; Pekka Mäntsälä
Isolation and characterization of 8-demethoxy steffimycins and generation of 2,8-demethoxy steffimycins in Streptomyces steffisburgensis by the nogalamycin biosynthesis genes.
The Journal of antibiotics 1997;50(6):496-501.
1996: Kristiina Ylihonko; Juha Hakala; Tero Kunnari; Pekka Mäntsälä
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.
Microbiology (Reading, England) 1996;142 ( Pt 8)():1965-72.
1996: Juha Hakala; M Lindvall; ari koskinen
Modelling constrained calcitonin gene-related peptide analogues.
Protein engineering 1996;9(2):143-8.
1994: Juha Hakala; Mauno Vihinen
Modelling the structure of the calcitonin gene-related peptide.
Protein engineering 1994;7(9):1069-75.
1994: Juha Hakala
Modelling the peptide receptor interaction: selectivity of the oxytocin receptor.
Biochemical and biophysical research communications 1994;202(3):1569-73.
1994: Juha Hakala; T Valo; S Vihavainen; Jorma Hermonen; P Heino; M Halme; ari koskinen
Constrained analogues of the calcitonin gene-related peptide.
Biochemical and biophysical research communications 1994;202(1):497-503.
1994: Kristiina Ylihonko; Juha Hakala; Jarmo Niemi; J Lundell; Pekka Mäntsälä
Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants.
Microbiology (Reading, England) 1994;140 ( Pt 6)():1359-65.
1994: Jarmo Niemi; Kristiina Ylihonko; Juha Hakala; R Pärssinen; A Kopio; Pekka Mäntsälä
Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.
Microbiology (Reading, England) 1994;140 ( Pt 6)():1351-8.
1988: J M Grönroos; Heikki Aho; S S Meklin; Juha Hakala; Timo J Nevalainen
Pancreatic digestive enzymes and ultrastructure after chronic alcohol intake in the rat.
Experimental pathology 1988;35(4):197-208.