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Hideki Hakamata

Research Profile

Chemicals & Drugs

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Mouse

Anatomy

Physiology

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Arteriosclerosis

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Oxidation-Reduction

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Masaharu Hori; Maki Satoh; Kohichiro Furukawa; Yu-ichiro Sakamoto; Hideki Hakamata; Yoshihiro Komohara; Motohiro Takeya; Yutaka Sasaki; Akira Miyazaki; Seikoh Horiuchi
Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats.
Masaharu Hori; Akira Miyazaki; Harumi Tamagawa; Maki Satoh; Kohichiro Furukawa; Hideki Hakamata; Yutaka Sasaki; Seikoh Horiuchi
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages.
Nobutaka Ohgami; Ryoji Nagai; Mamoru Ikemoto; Hiroyuki Arai; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi; Hitoshi Nakayama
CD36, serves as a receptor for advanced glycation endproducts (AGE).

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All Publications

2004: Masaharu Hori; Maki Satoh; Kohichiro Furukawa; Yu-ichiro Sakamoto; Hideki Hakamata; Yoshihiro Komohara; Motohiro Takeya; Yutaka Sasaki; Akira Miyazaki; Seikoh Horiuchi
Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1689-95.
2004: Masaharu Hori; Akira Miyazaki; Harumi Tamagawa; Maki Satoh; Kohichiro Furukawa; Hideki Hakamata; Yutaka Sasaki; Seikoh Horiuchi
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages.
Biochemical and biophysical research communications 2004;320(2):501-5.
2002: Nobutaka Ohgami; Ryoji Nagai; Mamoru Ikemoto; Hiroyuki Arai; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi; Hitoshi Nakayama
CD36, serves as a receptor for advanced glycation endproducts (AGE).
Journal of diabetes and its complications 2002;16(1):56-9.
2000: Nobutaka Ohgami; Akihiko Kuniyasu; Kohichiro Furukawa; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi; Hitoshi Nakayama
Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme.
Biochemical and biophysical research communications 2000;277(2):417-22.
2000: Akira Miyazaki; T Biwa; Hideki Hakamata; Masakazu Sakai; Yu-Ichiro Sakamoto; KK Maung; M Yuksel; Seikoh Horiuchi
Granulocyte macrophage colony-stimulating factor plays a priming role in murine macrophage growth induced by oxidized low density lipoprotein.
Annals of the New York Academy of Sciences 2000;902():342-6.
2000: T Biwa; Masakazu Sakai; Takeshi Matsumura; S Kobori; K Kaneko; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi; Motoaki Shichiri
Sites of action of protein kinase C and phosphatidylinositol 3-kinase are distinct in oxidized low density lipoprotein-induced macrophage proliferation.
The Journal of biological chemistry 2000;275(8):5810-6.
1999: Hitoshi Nakayama; Nobutaka Ohgami; Akihiko Kuniyasu; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi
[Glibenclamide inhibits cholesterol metabolism in macrophage].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():150P-153P.
1998: T Biwa; Hideki Hakamata; Masakazu Sakai; Akira Miyazaki; H Suzuki; T Kodama; Motoaki Shichiri; Seikoh Horiuchi
Induction of murine macrophage growth by oxidized low density lipoprotein is mediated by granulocyte macrophage colony-stimulating factor.
The Journal of biological chemistry 1998;273(43):28305-13.
1998: Akira Miyazaki; Naomi Sakashita; Oneil Lee; Kiyoshi Takahashi; Seikoh Horiuchi; Hideki Hakamata; Peter M Morganelli; Catherine C Y Chang; Ta-Yuan Chang
Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1568-74.
1998: Hideki Hakamata; H Sakaguchi; C Zhang; Naomi Sakashita; Hiroshi Suzuki; Akira Miyazaki; Motohiro Takeya; Kiyoshi Takahashi; N Kitamura; Seikoh Horiuchi
The very low- and intermediate-density lipoprotein fraction isolated from apolipoprotein E-knockout mice transforms macrophages to foam cells through an apolipoprotein E-independent pathway.
Biochemistry 1998;37(39):13720-7.
1998: Yoshiteru Jinnouchi; H Sano; Ryoji Nagai; Hideki Hakamata; Tatsuhiko Kodama; Hiroshi Suzuki; M Yoshida; Shoichi Ueda; Seikoh Horiuchi
Glycolaldehyde-modified low density lipoprotein leads macrophages to foam cells via the macrophage scavenger receptor.
Journal of biochemistry 1998;123(6):1208-17.
1998: Masakazu Sakai; Motoaki Shichiri; Hideki Hakamata; Seikoh Horiuchi
Endocytosed lysophosphatidylcholine, through the scavenger receptor, plays an essential role in oxidized low-density lipoprotein-induced macrophage proliferation.
Trends in cardiovascular medicine 1998;8(3):119-24.
1998: H Sakaguchi; Motohiro Takeya; Hiroshi Suzuki; Hideki Hakamata; Tatsuhiko Kodama; Seikoh Horiuchi; S Gordon; Luc J van der Laan; Georg Kraal; S Ishibashi; N Kitamura; Kiyoshi Takahashi
Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice.
Laboratory investigation; a journal of technical methods and pathology 1998;78(4):423-34.
1998: H Matsuda; Hideki Hakamata; T Kawasaki; Naomi Sakashita; Akira Miyazaki; Kiyoshi Takahashi; Motoaki Shichiri; Seikoh Horiuchi
Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase.
Biochimica et biophysica acta 1998;1391(2):193-203.
1998: T Kawasaki; Akira Miyazaki; Hideki Hakamata; H Matsuda; Seikoh Horiuchi
Biochemical evidence for oligomerization of rat adrenal acyl-coenzyme A:cholesterol acyltransferase.
Biochemical and biophysical research communications 1998;244(2):347-52.
1998: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; H Matsuda; Hiroshi Suzuki; Tatsuhiko Kodama; Seikoh Horiuchi
Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.
Journal of lipid research 1998;39(3):482-94.
1998: Y Ding; Hideki Hakamata; H Matsuda; Takayuki Kawano; T Kawasaki; Akira Miyazaki; Seikoh Horiuchi
Reduced expression of the macrophage scavenger receptors in macrophage-like cell mutants resistant to brefeldin A.
Biochemical and biophysical research communications 1998;243(1):277-83.
1998: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Yu-ichiro Sakamoto; Seikoh Horiuchi
Cytotoxic effect of oxidized low density lipoprotein on macrophages.
Journal of atherosclerosis and thrombosis 1998;5(2):66-75.
1997: Takeshi Matsumura; Masakazu Sakai; S Kobori; T Biwa; T Takemura; H Matsuda; Hideki Hakamata; Seikoh Horiuchi; Motoaki Shichiri
Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):3013-20.
1997: Takayuki Kawano; Hideki Hakamata; T Ohta; Y Ding; M Yoshida; S Ueda; Seikoh Horiuchi
Inhibitory effects of HepG2 cell-derived apolipoprotein A-I-containing lipoproteins on cholesteryl ester accumulation in macrophages.
Biochemistry 1997;36(32):9816-25.
1997: Masakazu Sakai; S Kobori; Takeshi Matsumura; T Biwa; Y Sato; T Takemura; Hideki Hakamata; Seikoh Horiuchi; Motoaki Shichiri
HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein.
Atherosclerosis 1997;133(1):51-9.
1997: Masakazu Sakai; Takeshi Matsumura; T Biwa; Hideki Hakamata; D Yi; Motoaki Shichiri; Seikoh Horiuchi
Role of the macrophage scavenger receptor for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage growth.
Annals of the New York Academy of Sciences 1997;811():378-84.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; Tatsuhiko Kodama; Hiroshi Suzuki; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
The scavenger receptor serves as a route for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage proliferation.
The Journal of biological chemistry 1996;271(44):27346-52.
1996: S Kitajima; S Sakuma; Y Uchinuno; T Terano; A Miyazaki; Hideki Hakamata; S Horiuchi
Quantitative analyses of lesion areas of coronary atherosclerosis in cholesterol-fed rabbits.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1996;58(9):855-60.
1996: H Matsuda; Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Catherine C Y Chang; Ta-Yuan Chang; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
Activation of acyl-coenzyme A:cholesterol acyltransferase activity by cholesterol is not due to altered mRNA levels in HepG2 cells.
Biochimica et biophysica acta 1996;1301(1-2):76-84.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; Y Sato; Takeshi Matsumura; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
Lysophosphatidylcholine potentiates the mitogenic activity of modified LDL for human monocyte-derived macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(4):600-5.
1996: Y Suginohara; Akira Miyazaki; Hideki Hakamata; Y Sakamoto; T Ohta; I Matsuda; Seikoh Horiuchi
The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages.
Atherosclerosis 1996;120(1-2):167-79.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; Y Suginohara; Y I Sakamoto; W Morikawa; S Kobori; M Schichiri; Seikoh Horiuchi
Reconstituted high density lipoprotein reduces the capacity of oxidatively modified low density lipoprotein to accumulate cholesteryl esters in mouse peritoneal macrophages.
Atherosclerosis 1996;119(2):191-202.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
Endocytic uptake of lysophosphatidylcholine mediated by macrophage scavenger receptor plays a major role in oxidized low density lipoprotein-induced macrophage growth.
Journal of atherosclerosis and thrombosis 1996;2(2):81-6.
1995: Akira Miyazaki; S Sakuma; W Morikawa; T Takiue; F Miake; T Terano; Masakazu Sakai; Hideki Hakamata; Y Sakamoto; M Natio
Intravenous injection of rabbit apolipoprotein A-I inhibits the progression of atherosclerosis in cholesterol-fed rabbits.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):1882-8.
1995: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Y I Sakamoto; H Matsuda; K Kihara; Seikoh Horiuchi
Differential effects of an acyl-coenzyme A:cholesterol acyltransferase inhibitor on HDL-induced cholesterol efflux from rat macrophage foam cells.
FEBS letters 1995;363(1-2):29-32.
1995: Akira Miyazaki; Masakazu Sakai; Hideki Hakamata; Seikoh Horiuchi
Multi-functional aspects of high density lipoprotein as an anti-atherogenic lipoprotein in vivo: evidence from in vitro experiments using macrophages.
Journal of atherosclerosis and thrombosis 1995;2(1):30-6.
1994: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; T Sasaki; S Yui; M Yamazaki; Motoaki Shichiri; Seikoh Horiuchi
Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.
The Journal of biological chemistry 1994;269(50):31430-5.
1994: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Y Suginohara; Y Sakamoto; Seikoh Horiuchi
Species difference in cholesteryl ester cycle and HDL-induced cholesterol efflux from macrophage foam cells.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(11):1860-5.
1994: T Mori; K Takahashi; M Naito; Tatsuhiko Kodama; Hideki Hakamata; Masakazu Sakai; Akira Miyazaki; Seikoh Horiuchi; M Ando
Endocytic pathway of scavenger receptors via trans-Golgi system in bovine alveolar macrophages.
Laboratory investigation; a journal of technical methods and pathology 1994;71(3):409-16.
1994: Akira Miyazaki; Masakazu Sakai; Y Suginohara; Hideki Hakamata; Y Sakamoto; W Morikawa; Seikoh Horiuchi
Acetylated low density lipoprotein reduces its ligand activity for the scavenger receptor after interaction with reconstituted high density lipoprotein.
The Journal of biological chemistry 1994;269(7):5264-9.