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Roni Haklai

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Mice
Rats

Phenomena

Methylation

Physiology

Anatomy

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Co-Publications
Name
31
Kloog, Yoel
10
Elad-Sfadia, Galit
8
Marciano, Daniele
7
Egozi, Yaakov
7
Ben-Baruch, Gilad
3
Ashery, Uri
3
Elad, Galit
3
Gana-Weisz, Mali
3
Paz, A
3
Rotblat, Barak
2
Keren, Gad
2
Keren, Pnina
2
Yizhar, Ofer
2
George, Jacob
2
Goldberg, Iris

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Publications

TOP 3
Kofer-Geles Merav; Gottfried Irit; Haklai Roni; Elad-Zefadia Galit; Kloog Yoel; Ashery Uri
Rasosomes spread Ras signals from plasma membrane 'hotspots'.
Goldberg Liat; Haklai Roni; Bauer Victor; Heiss Aaron; Kloog Yoel
New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models.
Rotshenker Shlomo; Reichert Fanny; Gitik Miri; Haklai Ronit; Elad-Sfadia Galit; Kloog Yoel
Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia.

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All Publications

2009: Kofer-Geles Merav; Gottfried Irit; Haklai Roni; Elad-Zefadia Galit; Kloog Yoel; Ashery Uri
Rasosomes spread Ras signals from plasma membrane 'hotspots'.
Biochimica et biophysica acta 2009;1793(11):1691-702.
2009: Goldberg Liat; Haklai Roni; Bauer Victor; Heiss Aaron; Kloog Yoel
New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models.
Journal of medicinal chemistry 2009;52(1):197-205.
2008: Rotshenker Shlomo; Reichert Fanny; Gitik Miri; Haklai Ronit; Elad-Sfadia Galit; Kloog Yoel
Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia.
Glia 2008;56(15):1607-13.
2008: Haklai Roni; Elad-Sfadia Galit; Egozi Yaakov; Kloog Yoel
Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice.
Cancer chemotherapy and pharmacology 2008;61(1):89-96.
2008: Rotblat Barak; Ehrlich Marcello; Haklai Roni; Kloog Yoel
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
Methods in enzymology 2008;439():467-89.
2007: Zundelevich Adi; Elad-Sfadia Galit; Haklai Ronit; Kloog Yoel
Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid).
Molecular cancer therapeutics 2007;6(6):1765-73.
2006: Even-Tzur Nurit; Elad David; Zaretsky Uri; Randell Scott H; Haklai Roni; Wolf Michael
Custom-designed wells and flow chamber for exposing air-liquid interface cultures to wall shear stress.
Annals of biomedical engineering 2006;34(12):1890-5.
2006: Ashery Uri; Yizhar Ofer; Rotblat Barak; Elad-Sfadia Galit; Barkan Batya; Haklai Roni; Kloog Yoel
Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch.
Cellular and molecular neurobiology 2006;26(4-6):471-95.
2006: Rotblat Barak; Yizhar Ofer; Haklai Roni; Ashery Uri; Kloog Yoel
Ras and its signals diffuse through the cell on randomly moving nanoparticles.
Cancer research 2006;66(4):1974-81.
2006: Beiner M E; Niv H; Haklai R; Elad-Sfadia G; Kloog Y; Ben-Baruch G
Ras antagonist inhibits growth and chemosensitizes human epithelial ovarian cancer cells.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16 Suppl 1():200-6.
2005: Yaari Shira; Jacob-Hirsch Jasmine; Amariglio Ninette; Haklai Ronit; Rechavi Gideon; Kloog Yoel
Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(12):4321-30.
2004: Elad-Sfadia Galit; Haklai Roni; Balan Eyal; Kloog Yoel
Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity.
The Journal of biological chemistry 2004;279(33):34922-30.
2004: George Jacob; Sack Jessica; Barshack Iris; Keren Pnina; Goldberg Iris; Haklai Roni; Elad-Sfadia Galit; Kloog Yoel; Keren Gad
Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(2):363-8.
2003: Shohami Esther; Yatsiv Ido; Alexandrovich Alexander; Haklai Roni; Elad-Sfadia Galit; Grossman Rachel; Biegon Anat; Kloog Yoel
The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(6):728-38.
2002: Elad-Sfadia Galit; Haklai Roni; Ballan Eyal; Gabius Hans-Joachim; Kloog Yoel
Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase.
The Journal of biological chemistry 2002;277(40):37169-75.
2002: George Jacob; Afek Arnon; Keren Pnina; Herz Itzhak; Goldberg Iris; Haklai Roni; Kloog Yoel; Keren Gad
Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice.
Circulation 2002;105(20):2416-22.
2002: Gana-Weisz Mali; Halaschek-Wiener Julius; Jansen Burkhard; Elad Galit; Haklai Ronit; Kloog Yoel
The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):555-65.
2001: Paz A; Haklai R; Elad-Sfadia G; Ballan E; Kloog Y
Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation.
Oncogene 2001;20(51):7486-93.
1999: Elad G; Paz A; Haklai R; Marciano D; Cox A; Kloog Y
Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid.
Biochimica et biophysica acta 1999;1452(3):228-42.
1998: Aharonson Z; Gana-Weisz M; Varsano T; Haklai R; Marciano D; Kloog Y
Stringent structural requirements for anti-Ras activity of S-prenyl analogues.
Biochimica et biophysica acta 1998;1406(1):40-50.
1998: Haklai R; Weisz M G; Elad G; Paz A; Marciano D; Egozi Y; Ben-Baruch G; Kloog Y
Dislodgment and accelerated degradation of Ras.
Biochemistry 1998;37(5):1306-14.
1997: Gana-Weisz M; Haklai R; Marciano D; Egozi Y; Ben-Baruch G; Kloog Y
The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation.
Biochemical and biophysical research communications 1997;239(3):900-4.
1995: Marom M; Haklai R; Ben-Baruch G; Marciano D; Egozi Y; Kloog Y
Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid.
The Journal of biological chemistry 1995;270(38):22263-70.
1995: Marciano D; Ben-Baruch G; Marom M; Egozi Y; Haklai R; Kloog Y
Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth.
Journal of medicinal chemistry 1995;38(8):1267-72.
1993: Paz A; Ben-Baruch G; Marciano D; Egozi Y; Haklai R; Kloog Y
Prenylated protein methyltransferase of rat cerebellum is developmentally co-expressed with its substrates.
FEBS letters 1993;332(3):215-7.
1993: Ben Baruch G; Paz A; Marciano D; Egozi Y; Haklai R; Kloog Y
The uniquely distributed isoprenylated protein methyltransferase activity in the rat brain is highly expressed in the cerebellum.
Biochemical and biophysical research communications 1993;195(1):282-8.
1993: Haklai R; Lerner S; Kloog Y
Nerve growth factor induces a succession of increases in isoprenylated methylated small GTP-binding proteins of PC-12 pheochromocytoma cells.
Neuropeptides 1993;24(1):11-25.
1992: Lerner S; Haklai R; Kloog Y
Isoprenylation and carboxylmethylation in small GTP-binding proteins of pheochromocytoma (PC-12) cells.
Cellular and molecular neurobiology 1992;12(4):333-51.
1991: Haklai R; Kloog Y
Relationship among methylation, isoprenylation, and GTP binding in 21- to 23-kDa proteins of neuroblastoma.
Cellular and molecular neurobiology 1991;11(4):415-33.
1990: Haklai R; Kloog Y
Methylation of 21-23 kD membrane proteins by a membrane-associated protein carboxyl methyltransferase in neuroblastoma cells. Increased methylation in differentiated cells.
Biochemical pharmacology 1990;40(6):1365-72.
1990: Haklai R; Kloog Y
Carboxyl methylation of 21-23 kDa membrane proteins in intact neuroblastoma cells is increased with differentiation.
FEBS letters 1990;259(2):233-6.
1987: Haklai R; Kloog Y
Purification and characterization of protein carboxyl methyltransferase from Torpedo ocellata electric organ.
Biochemistry 1987;26(14):4200-6.

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