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Thanos Halazonetis

Research Profile

Chemicals & Drugs

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DNA Damage

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Remco P Crefcoeur; Roman Ulm; Ruohe Yin; Thanos D Halazonetis
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells.
Sergey I Nikolaev; Ioannis S Pateras; Daniel Robyr; Janna Saarela; Federico Santoni; Sotirios K Sotiriou; Stavros Sougioultzis; Henrikki Almusa; Stylianos E Antonarakis; Henrik Edgren; Vassilis G Gorgoulis; Michel Guipponi; Thanos D Halazonetis
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
Masaoki Kohzaki; Shunichi Takeda; Gwennaelle Versini; Noritaka Adachi; Maria Chiourea; Sarantis Gagos; Thanos D Halazonetis
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.

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2013: Remco P Crefcoeur; Roman Ulm; Ruohe Yin; Thanos D Halazonetis
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells.
Nature communications 2013;4():1779.
2012: Sergey I Nikolaev; Ioannis S Pateras; Daniel Robyr; Janna Saarela; Federico Santoni; Sotirios K Sotiriou; Stavros Sougioultzis; Henrikki Almusa; Stylianos E Antonarakis; Henrik Edgren; Vassilis G Gorgoulis; Michel Guipponi; Thanos D Halazonetis
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
Cancer research 2012;72(23):6279-89.
2012: Masaoki Kohzaki; Shunichi Takeda; Gwennaelle Versini; Noritaka Adachi; Maria Chiourea; Sarantis Gagos; Thanos D Halazonetis
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.
Carcinogenesis 2012;33(6):1203-10.
2012: Taisuke Nishimura; Tom Petty; Stéphane Thore; Larissa Broger; Caroline Gabus; Thanos D Halazonetis; Guillaume Molinard; Jerzy Paszkowski
Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.
PLoS genetics 2012;8(2):e1002484.
2012: Sergey I Nikolaev; Donata Rimoldi; Daniel Robyr; Daniel Speiser; Brian J Stevenson; Armand Valsesia; Ioannis Xenarios; Vincent Zoete; Jacques Beckmann; Olesya Bukach; Corinne Gehrig; Michel Guipponi; Thanos D Halazonetis; Keith Harshman; Christian Iseli; Victor Jongeneel; Olivier Michielin; Katja Muehlethaler; Stylianos E Antonarakis
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.
Nature genetics 2012;44(2):133-9.
2011: Soheila Emamzadah; Laurence Tropia; Thanos D Halazonetis
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element.
Molecular cancer research : MCR 2011;9(11):1493-9.
2011: Aygül Dereli-Öz; Gwennaelle Versini; Thanos D Halazonetis
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress.
Molecular oncology 2011;5(4):308-14.
2011: Tom Petty; Soheila Emamzadah; Lorenzo Costantino; Irina Petkova; Elena S Stavridi; Jeffery G Saven; Eric Vauthey; Thanos D Halazonetis
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
The EMBO journal 2011;30(11):2167-76.
2011: Maciej K Kocylowski; Thanos D Halazonetis
SAHF, to senesce or not to senesce?
Cell cycle (Georgetown, Tex.) 2011;10(5):738-9.
2010: Vassilis G Gorgoulis; Thanos D Halazonetis
Oncogene-induced senescence: the bright and dark side of the response.
Current opinion in cell biology 2010;22(6):816-27.
2010: Rachele Cescutti; Simona Negrini; Masaoki Kohzaki; Thanos D Halazonetis
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
The EMBO journal 2010;29(21):3723-32.
2010: Tom Petty; Taisuke Nishimura; Soheila Emamzadah; Caroline Gabus; Jerzy Paszkowski; Thanos D Halazonetis; Stéphane Thore
Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 8):916-8.
2010: Masaoki Kohzaki; Kana Nishihara; Kouji Hirota; Eiichiro Sonoda; Michio Yoshimura; Shigeo Ekino; John E Butler; Masami Watanabe; Thanos D Halazonetis; Shunichi Takeda
DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.
The Journal of cell biology 2010;189(7):1117-27.
2010: Zhaoyuan Hou; Hongzhuang Peng; David E White; Pu Wang; Paul M Lieberman; Thanos D Halazonetis; Frank J Rauscher
14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiation.
Cancer research 2010;70(11):4385-93.
2010: Simona Negrini; Vassilis G Gorgoulis; Thanos D Halazonetis
Genomic instability--an evolving hallmark of cancer.
Nature reviews. Molecular cell biology 2010;11(3):220-8.
2009: Harri Lempiäinen; Thanos D Halazonetis
Emerging common themes in regulation of PIKKs and PI3Ks.
The EMBO journal 2009;28(20):3067-73.
2009: Soheila Emamzadah; Tom Petty; Victor De Almeida; Taisuke Nishimura; Jacques Joly; Jean Luc Ferrer; Thanos D Halazonetis
Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 9):913-20.
2009: Kristopher Pataky; Guillermo Villanueva; andre liani; Omar Zgheib; Nathan Jenkins; Demetrios J Halazonetis; Thanos D Halazonetis; Jürgen Brugger
Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays.
Radiation research 2009;172(2):252-9.
2009: Michalis Liontos; Katerina Niforou; Georgia Velimezi; Konstantinos Vougas; Konstantinos Evangelou; Kalliopi Apostolopoulou; Radek Vrtel; Alexandros Damalas; Panayiotis Kontovazenitis; Athanassios Kotsinas; Vassilis Zoumpourlis; George Th Tsangaris; Christos Kittas; Doron Ginsberg; Thanos D Halazonetis; Jiri Bartek; Vassilis G Gorgoulis
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.
The American journal of pathology 2009;175(1):376-91.
2009: Omar Zgheib; Kristopher Pataky; Juergen Brugger; Thanos D Halazonetis
An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.
Molecular and cellular biology 2009;29(4):1050-8.
2008: Thanos D Halazonetis; Vassilis G Gorgoulis; Jiri Bartek
An oncogene-induced DNA damage model for cancer development.
Science (New York, N.Y.) 2008;319(5868):1352-5.
2007: Robyn L Tuttle; John Bothos; Matthew K Summers; Francis C Luca; Thanos D Halazonetis
Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network.
Molecular cancer research : MCR 2007;5(12):1304-11.
2007: Michalis Liontos; Marilena K Koutsami; Maria Sideridou; Konstantinos Evangelou; Dimitris Kletsas; Brynn Levy; Athanassios Kotsinas; Odelia Nahum; Vassilis Zoumpourlis; Mirsini Kouloukoussa; Zoi Lygerou; Stavros Taraviras; Christos Kittas; Jirina Bartkova; Athanasios G Papavassiliou; Jiri Bartek; Thanos D Halazonetis; Vassilis G Gorgoulis
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
Cancer research 2007;67(22):10899-909.
2007: Monica Venere; Andrew R Snyder; Omar Zgheib; Thanos D Halazonetis
Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
Cancer research 2007;67(13):6100-5.
2007: K Tsimaratou; Dimitris Kletsas; Nikolaos G Kastrinakis; Petros K Tsantoulis; Konstantinos Evangelou; Maria Sideridou; Michalis Liontos; Iraklis Poulias; Monica Venere; M Salmas; Christos Kittas; Thanos D Halazonetis; Vassilis G Gorgoulis
Evaluation of claspin as a proliferation marker in human cancer and normal tissues.
The Journal of pathology 2007;211(3):331-9.
2006: Thanos D Halazonetis; Jiri Bartek
DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter.
Molecular cell 2006;24(6):809-10.
2006: Jirina Bartkova; Nousin Rezaei; Michalis Liontos; Panagiotis Karakaidos; Dimitris Kletsas; Natalia Issaeva; Leandros-Vassilios F Vassiliou; Evangelos Kolettas; Katerina Niforou; Vassilis C Zoumpourlis; Munenori Takaoka; Hiroshi Nakagawa; Frederic Tort; Kasper Fugger; Fredrik Johansson; Maxwell Sehested; Claus L Andersen; Lars Dyrskjot; Torben F Ørntoft; Jiri Lukas; Christos Kittas; Thomas Helleday; Thanos D Halazonetis; Jiri Bartek; Vassilis G Gorgoulis
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Nature 2006;444(7119):633-7.
2006: Angelo Peschiaroli; N Valerio Dorrello; Daniele Guardavaccaro; Monica Venere; Thanos D Halazonetis; Nicholas E Sherman; Michele Pagano
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Molecular cell 2006;23(3):319-29.
2006: Jiri Lukas; Vilhelm A Bohr; Thanos D Halazonetis
Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium.
DNA repair 2006;5(5):591-601.
2005: Mark Livingstone; Hong Ruan; Jessica Weiner; Karl R Clauser; Peter Strack; Shengfang Jin; Amy Williams; Heidi Greulich; James Gardner; Monica Venere; Tamara A Mochan; Richard A DiTullio; Katarina Moravcevic; Vassilis G Gorgoulis; Anne Burkhardt; Thanos D Halazonetis
Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.
Cancer research 2005;65(17):7533-40.
2005: John Bothos; Robyn L Tuttle; Michelle Ottey; Francis C Luca; Thanos D Halazonetis
Human LATS1 is a mitotic exit network kinase.
Cancer research 2005;65(15):6568-75.
2005: Omar Zgheib; Yentram Huyen; Richard A DiTullio; Andrew R Snyder; Monica Venere; Elena S Stavridi; Thanos D Halazonetis
ATM signaling and 53BP1.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2005;76(2):119-22.
2005: Elena S Stavridi; Thanos D Halazonetis
Nbs1 moving up in the world.
Nature cell biology 2005;7(7):648-50.
2005: Vassilis G Gorgoulis; Leandros-Vassilios F Vassiliou; Panagiotis Karakaidos; Panayotis Zacharatos; Athanassios Kotsinas; Triantafillos Liloglou; Monica Venere; Richard A DiTullio; Nikolaos G Kastrinakis; Brynn Levy; Dimitris Kletsas; Akihiro Yoneta; Meenhard Herlyn; Christos Kittas; Thanos D Halazonetis
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
Nature 2005;434(7035):907-13.
2005: Matthew K Summers; John Bothos; Thanos D Halazonetis
The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus.
Oncogene 2005;24(16):2589-98.
2004: Yentram Huyen; Omar Zgheib; Richard A DiTullio; Vassilis G Gorgoulis; Panayotis Zacharatos; Tom Petty; Emily A Sheston; Hestia S Mellert; Elena S Stavridi; Thanos D Halazonetis
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
Nature 2004;432(7015):406-11.
2004: David MacPherson; Jungho Kim; Teresa Kim; Byung Kirl Rhee; Conny Th M van Oostrom; Richard A DiTullio; Monica Venere; Thanos D Halazonetis; Roderick Bronson; Annemieke de Vries; Mark Fleming; Tyler Jacks
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.
The EMBO journal 2004;23(18):3689-99.
2004: Sagar Sengupta; Ana I Robles; Steven P Linke; Natasha I Sinogeeva; Ran Zhang; Remy Pedeux; Irene M Ward; Arkady Celeste; André Nussenzweig; Junjie Chen; Thanos D Halazonetis; Curtis C Harris
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
The Journal of cell biology 2004;166(6):801-13.
2004: Thanos D Halazonetis
Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer.
DNA repair 2004;3(8-9):1057-62.
2004: Tamara A Mochan; Monica Venere; Richard A DiTullio; Thanos D Halazonetis
53BP1, an activator of ATM in response to DNA damage.
DNA repair 2004;3(8-9):945-52.
2004: Yentram Huyen; Philip Jeffrey; W Brent Derry; Joel H Rothman; Nikola P Pavletich; Elena S Stavridi; Thanos D Halazonetis
Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.
Structure (London, England : 1993) 2004;12(7):1237-43.
2004: Elena S Stavridi; Thanos D Halazonetis
p53 and stress in the ER.
Genes & development 2004;18(3):241-4.
2003: Tamara A Mochan; Monica Venere; Richard A DiTullio; Thanos D Halazonetis
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
Cancer research 2003;63(24):8586-91.
2003: George Mariatos; John Bothos; Panayotis Zacharatos; Matthew K Summers; Daniel M Scolnick; Christos Kittas; Thanos D Halazonetis; Vassilis G Gorgoulis
Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.
Cancer research 2003;63(21):7185-9.
2003: John Bothos; Matthew K Summers; Monica Venere; Daniel M Scolnick; Thanos D Halazonetis
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.
Oncogene 2003;22(46):7101-7.
2003: Paul G Corn; Matthew K Summers; Franz Fogt; Arvind K Virmani; Adi F Gazdar; Thanos D Halazonetis; Wafik S El-Deiry
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Carcinogenesis 2003;24(1):47-51.
2002: Richard A DiTullio; Tamara A Mochan; Monica Venere; Jirina Bartkova; Maxwell Sehested; Jiri Bartek; Thanos D Halazonetis
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.
Nature cell biology 2002;4(12):998-1002.
2002: Monica Venere; Tamara A Mochan; Thanos D Halazonetis
Chk2 leaves the PML depot.
Nature cell biology 2002;4(11):E255-6.
2002: Elena S Stavridi; Yentram Huyen; Ivy R Loreto; Daniel M Scolnick; Thanos D Halazonetis; Nikola P Pavletich; Philip Jeffrey
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure (London, England : 1993) 2002;10(7):891-9.
2001: Nickolai A Barlev; L Liu; NH Chehab; K Mansfield; K G Harris; Thanos D Halazonetis; Shelley L Berger
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.
Molecular cell 2001;8(6):1243-54.
2001: Elena S Stavridi; NH Chehab; A Malikzay; Thanos D Halazonetis
Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest.
Cancer research 2001;61(19):7030-3.
2000: L B Schultz; NH Chehab; A Malikzay; Thanos D Halazonetis
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks.
The Journal of cell biology 2000;151(7):1381-90.
2000: Caterina Cinti; Pier Paolo Claudio; A D Luca; M Cuccurese; Candace M Howard; Maurizio D'Esposito; Marco Giorgio Paggi; D L Sala; L Azzoni; Thanos D Halazonetis; Antonio Giordano; Nadir M Maraldi
A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line.
Oncogene 2000;19(44):5098-105.
2000: Kapaettu Satyamoorthy; NH Chehab; M J Waterman; M C Lien; Wafik S El-Deiry; Meenhard Herlyn; Thanos D Halazonetis
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(9):467-74.
2000: Daniel M Scolnick; Thanos D Halazonetis
Chfr defines a mitotic stress checkpoint that delays entry into metaphase.
Nature 2000;406(6794):430-5.
2000: NH Chehab; A Malikzay; M Appel; Thanos D Halazonetis
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.
Genes & development 2000;14(3):278-88.
2000: L B Schultz; NH Chehab; A Malikzay; Richard A DiTullio; Elena S Stavridi; Thanos D Halazonetis
The DNA damage checkpoint and human cancer.
Cold Spring Harbor symposia on quantitative biology 2000;65():489-98.
1999: NH Chehab; A Malikzay; Elena S Stavridi; Thanos D Halazonetis
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13777-82.
1999: Thanos D Halazonetis; Y Shiloh
Many faces of ATM: eighth international workshop on ataxia-telangiectasia.
Biochimica et biophysica acta 1999;1424(2-3):R45-55.
1999: Elena S Stavridi; NH Chehab; L C Caruso; Thanos D Halazonetis
Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions.
Protein science : a publication of the Protein Society 1999;8(9):1773-9.
1999: K Megyeri; Klara Berencsi; Thanos D Halazonetis; G C Prendergast; G Gri; SA Plotkin; G Rovera; Eva Gönczöl
Involvement of a p53-dependent pathway in rubella virus-induced apoptosis.
Virology 1999;259(1):74-84.
1999: L Liu; Daniel M Scolnick; Raymond C Trievel; H B Zhang; Ronen Marmorstein; Thanos D Halazonetis; Shelley L Berger
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.
Molecular and cellular biology 1999;19(2):1202-9.
1999: Panayotis Zacharatos; Vassilis G Gorgoulis; Athanassios Kotsinas; Evangelos N Manolis; Triantafillos Liloglou; AN Rassidakis; Panagiotis Kanavaros; J D Field; Thanos D Halazonetis; Christos Kittas
Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1.
Anticancer research 1999;19(1A):579-87.
1998: Vassilis G Gorgoulis; Panayotis Zacharatos; Athanassios Kotsinas; Triantafillos Liloglou; Aspasia Kyroudi; Marinos Veslemes; AN Rassidakis; Thanos D Halazonetis; John Field; Christos Kittas
Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression.
The American journal of pathology 1998;153(6):1749-65.
1998: M J Waterman; Elena S Stavridi; J L Waterman; Thanos D Halazonetis
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins.
Nature genetics 1998;19(2):175-8.
1998: B F Müller-Tiemann; Thanos D Halazonetis; J J Elting
Identification of an additional negative regulatory region for p53 sequence-specific DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6079-84.
1998: Vassilis G Gorgoulis; Panayotis Zacharatos; Evangelos N Manolis; John Ikonomopoulos; Alexander Damalas; C Lamprinopoulos; George Z Rassidakis; Vassilis Zoumpourlis; Athanassios Kotsinas; AN Rassidakis; Thanos D Halazonetis; Christos Kittas
Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.
British journal of cancer 1998;77(3):374-84.
1997: M McCoy; Elena S Stavridi; J L Waterman; A M Wieczorek; S J Opella; Thanos D Halazonetis
Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.
The EMBO journal 1997;16(20):6230-6.
1997: Daniel M Scolnick; NH Chehab; Elena S Stavridi; M C Lien; L Caruso; E Moran; Shelley L Berger; Thanos D Halazonetis
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.
Cancer research 1997;57(17):3693-6.
1997: R Candau; Daniel M Scolnick; P Darpino; CY Ying; Thanos D Halazonetis; Shelley L Berger
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity.
Oncogene 1997;15(7):807-16.
1996: A M Wieczorek; J L Waterman; M J Waterman; Thanos D Halazonetis
Structure-based rescue of common tumor-derived p53 mutants.
Nature medicine 1996;2(10):1143-6.
1996: M J Waterman; J L Waterman; Thanos D Halazonetis
An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants.
Cancer research 1996;56(1):158-63.
1995: J L Waterman; J L Shenk; Thanos D Halazonetis
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.
The EMBO journal 1995;14(3):512-9.
1993: Thanos D Halazonetis; A N Kandil
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
The EMBO journal 1993;12(13):5057-64.
1993: Thanos D Halazonetis; L J Davis; A N Kandil
Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.
The EMBO journal 1993;12(3):1021-8.
1993: L J Davis; Thanos D Halazonetis
Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.
Oncogene 1993;8(1):125-32.
1992: Thanos D Halazonetis
An enhancer "core" DNA-binding and transcriptional activity is induced upon transformation of rat embryo fibroblasts.
Anticancer research 1992;12(2):285-91.
1992: Thanos D Halazonetis; A N Kandil
Predicted structural similarities of the DNA binding domains of c-Myc and endonuclease Eco RI.
Science (New York, N.Y.) 1992;255(5043):464-6.
1991: A Rosenzweig; Thanos D Halazonetis; Jonathan G Seidman; Christine E Seidman
Proximal regulatory domains of rat atrial natriuretic factor gene.
Circulation 1991;84(3):1256-65.
1991: A G Hatziioannou; C M Krauss; M B Lewis; Thanos D Halazonetis
Familial holoprosencephaly associated with a translocation breakpoint at chromosomal position 7q36.
American journal of medical genetics 1991;40(2):201-5.
1991: Thanos D Halazonetis; A N Kandil
Determination of the c-MYC DNA-binding site.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6162-6.
1990: K Zhang; J R Chaillet; L A Perkins; Thanos D Halazonetis; Norbert Perrimon
Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6281-5.
1989: Thanos D Halazonetis; Anne D Haffajee; Sigmund S Socransky
Relationship of clinical parameters to attachment loss in subsets of subjects with destructive periodontal diseases.
Journal of clinical periodontology 1989;16(9):563-8.
1988: Thanos D Halazonetis; K Georgopoulos; Michael E Greenberg; Philip Leder
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.
Cell 1988;55(5):917-24.
1988: Thanos D Halazonetis; C Daugherty; Philip Leder
Retinoic acid increases the sensitivity of the rat embryo fibroblast transformation assay.
Molecular and cellular biology 1988;8(4):1845-8.
1987: J Sarid; Thanos D Halazonetis; W Murphy; P Leder
Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):170-3.