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Barbara Hales

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
36
Robaire, Bernard
6
Trasler, Jacquetta
6
Vinson, Robert
5
Aguilar-Mahecha, Adriana
4
Codrington, Alexis
4
Barton, Tara
4
Cyr, Daniel
4
Harrouk, Wafa
4
Ozolins, Terence
3
Adeeko, Adedayo
3
Li, Daming
3
Ali-Khan, Sarah
2
Barthelemy, Johanna
2
Cooke, Gerard
2
Delbes, Géraldine

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Publications

TOP 3
Larouche Geneviève; Hales Barbara F
The impact of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea.
Huang Chunwei; Hales Barbara F
Teratogen responsive signaling pathways in organogenesis stage mouse limbs.
Gnanabakthan Naveen; Hales Barbara F
The oxidative stress response is region specific in organogenesis stage mouse embryos exposed to 5-bromo-2'-deoxyuridine.

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All Publications

2009: Larouche Geneviève; Hales Barbara F
The impact of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea.
Birth defects research. Part A, Clinical and molecular teratology 2009;85(9):800-7.
2009: Huang Chunwei; Hales Barbara F
Teratogen responsive signaling pathways in organogenesis stage mouse limbs.
Reproductive toxicology (Elmsford, N.Y.) 2009;27(2):103-10.
2009: Gnanabakthan Naveen; Hales Barbara F
The oxidative stress response is region specific in organogenesis stage mouse embryos exposed to 5-bromo-2'-deoxyuridine.
Birth defects research. Part A, Clinical and molecular teratology 2009;85(3):202-10.
2009: Delbès Geraldine; Chan Donovan; Pakarinen Pirjo; Trasler Jacquetta M; Hales Barbara F; Robaire Bernard
Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway rats.
Biology of reproduction 2009;80(2):320-7.
2008: Galdones Eugene; Hales Barbara F
Retinoic acid receptor gamma-induced misregulation of chondrogenesis in the murine limb bud in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):223-32.
2008: Yan Jin; Hales Barbara F
p38 and c-Jun N-terminal kinase mitogen-activated protein kinase signaling pathways play distinct roles in the response of organogenesis-stage embryos to a teratogen.
The Journal of pharmacology and experimental therapeutics 2008;326(3):764-72.
2008: Marcon Ludovic; Hales Barbara F; Robaire Bernard
Reversibility of the effects of subchronic exposure to the cancer chemotherapeutics bleomycin, etoposide, and cisplatin on spermatogenesis, fertility, and progeny outcome in the male rat.
Journal of andrology 2008;29(4):408-17.
2008: O'Flaherty C; Vaisheva F; Hales B F; Chan P; Robaire B
Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy.
Human reproduction (Oxford, England) 2008;23(5):1044-52.
2007: Barton Tara S; Robaire Bernard; Hales Barbara F
DNA damage recognition in the rat zygote following chronic paternal cyclophosphamide exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(2):495-503.
2007: Codrington Alexis M; Hales Barbara F; Robaire Bernard
Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins.
Biology of reproduction 2007;77(2):303-11.
2007: Vaisheva Farida; Delbes Geraldine; Hales Barbara F; Robaire Bernard
Effects of the chemotherapeutic agents for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), on the male rat reproductive system and progeny outcome.
Journal of andrology 2007;28(4):578-87.
2007: Codrington A M; Hales B F; Robaire B
Exposure of male rats to cyclophosphamide alters the chromatin structure and basic proteome in spermatozoa.
Human reproduction (Oxford, England) 2007;22(5):1431-42.
2007: Delbes Géraldine; Hales Barbara F; Robaire Bernard
Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity.
Journal of andrology 2007;28(2):241-9; discussion 250-1.
2007: Kishta Osama; Adeeko Adedayo; Li Daming; Luu Trang; Brawer James R; Morales Carlos; Hermo Louis; Robaire Bernard; Hales Barbara F; Barthelemy Johanna; Cyr Daniel G; Trasler Jacquetta M
In utero exposure to tributyltin chloride differentially alters male and female fetal gonad morphology and gene expression profiles in the Sprague-Dawley rat.
Reproductive toxicology (Elmsford, N.Y.) 2007;23(1):1-11.
2006: Yan Jin; Hales Barbara F
Depletion of glutathione induces 4-hydroxynonenal protein adducts and hydroxyurea teratogenicity in the organogenesis stage mouse embryo.
The Journal of pharmacology and experimental therapeutics 2006;319(2):613-21.
2006: Ali-Khan Sarah E; Hales Barbara F
Novel retinoid targets in the mouse limb during organogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(1):139-52.
2006: Sahambi Sukhdeep Kaur; Hales Barbara F
Exposure to 5-bromo-2'-deoxyuridine induces oxidative stress and activator protein-1 DNA binding activity in the embryo.
Birth defects research. Part A, Clinical and molecular teratology 2006;76(8):580-91.
2006: Ali-Khan Sarah E; Hales Barbara F
Retinoid receptor antagonists alter the pattern of apoptosis in organogenesis stage mouse limbs.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(1):208-20.
2006: Bieber Adrienne M; Marcon Ludovic; Hales Barbara F; Robaire Bernard
Effects of chemotherapeutic agents for testicular cancer on the male rat reproductive system, spermatozoa, and fertility.
Journal of andrology 2006;27(2):189-200.
2006: Galdones Eugene; Lohnes David; Hales Barbara F
Role of retinoic acid receptors alpha1 and gamma in the response of murine limbs to retinol in vitro.
Birth defects research. Part A, Clinical and molecular teratology 2006;76(1):39-45.
2005: Hales Barbara F; Aguilar-Mahecha Adriana; Robaire Bernard
The stress response in gametes and embryos after paternal chemical exposures.
Toxicology and applied pharmacology 2005;207(2 Suppl):514-20.
2005: Hales Barbara F
DNA repair disorders causing malformations.
Current opinion in genetics & development 2005;15(3):234-40.
2005: Yan Jin; Hales Barbara F
Activator protein-1 (AP-1) DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(2):1013-23.
2005: Aguilar-Mahecha Adriana; Hales Barbara F; Robaire Bernard
Effects of acute and chronic cyclophosphamide treatment on meiotic progression and the induction of DNA double-strand breaks in rat spermatocytes.
Biology of reproduction 2005;72(6):1297-304.
2005: Barton Tara S; Robaire Bernard; Hales Barbara F
Epigenetic programming in the preimplantation rat embryo is disrupted by chronic paternal cyclophosphamide exposure.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):7865-70.
2005: Hales Barbara F; Barton Tara S; Robaire Bernard
Impact of paternal exposure to chemotherapy on offspring in the rat.
Journal of the National Cancer Institute. Monographs 2005;(34):28-31.
2004: Codrington Alexis M; Hales Barbara F; Robaire Bernard
Spermiogenic germ cell phase-specific DNA damage following cyclophosphamide exposure.
Journal of andrology 2004;25(3):354-62.
2003: Ali-Khan Sarah E; Hales Barbara F
Caspase-3 mediates retinoid-induced apoptosis in the organogenesis-stage mouse limb.
Birth defects research. Part A, Clinical and molecular teratology 2003;67(10):848-60.
2003: Barton Tara S; Wyrobek Andrew J; Hill Francesca S; Robaire Bernard; Hales Barbara F
Numerical chromosomal abnormalities in rat epididymal spermatozoa following chronic cyclophosphamide exposure.
Biology of reproduction 2003;69(4):1150-7.
2003: Adeeko Adedayo; Li Daming; Forsyth Don S; Casey Valerie; Cooke Gerard M; Barthelemy Johanna; Cyr Daniel G; Trasler Jacquetta M; Robaire Bernard; Hales Barbara F
Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):407-15.
2003: Vinson Robert K; Hales Barbara F
Genotoxic stress response gene expression in the mid-organogenesis rat conceptus.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):157-64.
2003: Adeeko Adedayo; Li Daming; Doucet Josee; Cooke Gerard M; Trasler Jacquetta M; Robaire Bernard; Hales Barbara F
Gestational exposure to persistent organic pollutants: maternal liver residues, pregnancy outcome, and effects on hepatic gene expression profiles in the dam and fetus.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(2):242-52.
2003: Hales Barbara F; Cyr Daniel G
Study designs for the assessment of male-mediated developmental toxicity.
Advances in experimental medicine and biology 2003;518():271-7.
2003: Robaire Bernard; Hales Barbara F
Mechanisms of action of cyclophosphamide as a male-mediated developmental toxicant.
Advances in experimental medicine and biology 2003;518():169-80.
2002: Huang Chunwei; Hales Barbara F
Role of caspases in murine limb bud cell death induced by 4-hydroperoxycyclophosphamide, an activated analog of cyclophosphamide.
Teratology 2002;66(6):288-99.
2002: Vinson Robert K; Hales Barbara F
DNA repair during organogenesis.
Mutation research 2002;509(1-2):79-91.
2002: Ozolins Terence R S; Harrouk Wafa; Doerksen Tonia; Trasler Jacquetta M; Hales Barbara F
Buthionine sulfoximine embryotoxicity is associated with prolonged AP-1 activation.
Teratology 2002;66(4):192-200.
2002: Vinson Robert K; Hales Barbara F
Expression and activity of the DNA repair enzyme uracil DNA glycosylase during organogenesis in the rat conceptus and following methotrexate exposure in vitro.
Biochemical pharmacology 2002;64(4):711-21.
2002: Aguilar-Mahecha Adriana; Hales Barbara F; Robaire Bernard
Chronic cyclophosphamide treatment alters the expression of stress response genes in rat male germ cells.
Biology of reproduction 2002;66(4):1024-32.
2001: Vinson R K; Hales B F
Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide.
Teratology 2001;64(6):283-91.
2001: Hales B F; Robaire B
Paternal exposure to drugs and environmental chemicals: effects on progeny outcome.
Journal of andrology 2001;22(6):927-36.
2001: Aguilar-Mahecha A; Hales B F; Robaire B
Acute cyclophosphamide exposure has germ cell specific effects on the expression of stress response genes during rat spermatogenesis.
Molecular reproduction and development 2001;60(3):302-11.
2001: Vinson R K; Hales B F
Nucleotide excision repair gene expression in the rat conceptus during organogenesis.
Mutation research 2001;486(2):113-23.
2001: Aguilar-Mahecha A; Hales B F; Robaire B
Expression of stress response genes in germ cells during spermatogenesis.
Biology of reproduction 2001;65(1):119-27.
2000: Harrouk W; Codrington A; Vinson R; Robaire B; Hales B F
Paternal exposure to cyclophosphamide induces DNA damage and alters the expression of DNA repair genes in the rat preimplantation embryo.
Mutation research 2000;461(3):229-41.
2000: Harrouk W; Khatabaksh S; Robaire B; Hales B F
Paternal exposure to cyclophosphamide dysregulates the gene activation program in rat preimplantation embryos.
Molecular reproduction and development 2000;57(3):214-23.
2000: Harrouk W; Robaire B; Hales B F
Paternal exposure to cyclophosphamide alters cell-cell contacts and activation of embryonic transcription in the preimplantation rat embryo.
Biology of reproduction 2000;63(1):74-81.
2000: Lemasters G K; Perreault S D; Hales B F; Hatch M; Hirshfield A N; Hughes C L; Kimmel G L; Lamb J C; Pryor J L; Rubin C; Seed J G
Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary.
Environmental health perspectives 2000;108 Suppl 3():505-9.
2000: Pryor J L; Hughes C; Foster W; Hales B F; Robaire B
Critical windows of exposure for children's health: the reproductive system in animals and humans.
Environmental health perspectives 2000;108 Suppl 3():491-503.
1999: Ozolins T R; Hales B F
Post-translational regulation of AP-1 transcription factor DNA-binding activity in the rat conceptus.
Molecular pharmacology 1999;56(3):537-44.
1999: Ozolins T R; Hales B F
Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus.
Biochemical pharmacology 1999;57(10):1165-75.
1998: Moallem S A; Hales B F
The role of p53 and cell death by apoptosis and necrosis in 4-hydroperoxycyclophosphamide-induced limb malformations.
Development (Cambridge, England) 1998;125(16):3225-34.
1997: Cai L; Hales B F; Robaire B
Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide.
Biology of reproduction 1997;56(6):1490-7.
1997: Ozolins T R; Hales B F
Oxidative stress regulates the expression and activity of transcription factor activator protein-1 in rat conceptus.
The Journal of pharmacology and experimental therapeutics 1997;280(2):1085-93.
1996: Adel Moallem S; Hales B F
Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse.
Biology of reproduction 1996;55(2):281-90.
1995: Qiu J; Hales B F; Robaire B
Damage to rat spermatozoal DNA after chronic cyclophosphamide exposure.
Biology of reproduction 1995;53(6):1465-73.
1995: Chen B; Hales B F
Antisense oligonucleotide down-regulation of E-cadherin in the yolk sac and cranial neural tube malformations.
Biology of reproduction 1995;53(5):1229-38.
1995: Moallem S A; Hales B F
Induction of apoptosis and cathepsin D in limbs exposed in vitro to an activated analog of cyclophosphamide.
Teratology 1995;52(1):3-14.
1995: Qiu J; Hales B F; Robaire B
Effects of chronic low-dose cyclophosphamide exposure on the nuclei of rat spermatozoa.
Biology of reproduction 1995;52(1):33-40.
1994: Chen B; Hales B F
Cadmium-induced rat embryotoxicity in vitro is associated with an increased abundance of E-cadherin protein in the yolk sac.
Toxicology and applied pharmacology 1994;128(2):293-301.
1994: Chen B; Hales B F
12-O-tetradecanoyl-phorbol-13-acetate-induced rat embryo malformations in vitro are associated with an increased relative abundance of embryonic E-cadherin mRNA.
Teratology 1994;50(4):302-10.
1994: Chen B; Cyr D G; Hales B F
Role of apoptosis in mediating phosphoramide mustard-induced rat embryo malformations in vitro.
Teratology 1994;50(1):1-12.
1994: Hales B F; Huang C
Regulation of the Yp subunit of glutathione S-transferase P in rat embryos and yolk sacs during organogenesis.
Biochemical pharmacology 1994;47(11):2029-37.
1994: Austin S M; Robaire B; Hales B F; Kelly S M
Paternal cyclophosphamide exposure causes decreased cell proliferation in cleavage-stage embryos.
Biology of reproduction 1994;50(1):55-64.
1992: Kapron-Brás C M; Hales B F
Genetic differences in heat-induced tolerance to cadmium in cultured mouse embryos are not correlated with changes in a 68-kD heat shock protein.
Teratology 1992;46(2):191-200.
1992: Hales B F; Crosman K; Robaire B
Increased postimplantation loss and malformations among the F2 progeny of male rats chronically treated with cyclophosphamide.
Teratology 1992;45(6):671-8.
1992: Qiu J; Hales B F; Robaire B
Adverse effects of cyclophosphamide on progeny outcome can be mediated through post-testicular mechanisms in the rat.
Biology of reproduction 1992;46(5):926-31.
1992: Kelly S M; Robaire B; Hales B F
Paternal cyclophosphamide treatment causes postimplantation loss via inner cell mass-specific cell death.
Teratology 1992;45(3):313-8.
1991: Chen B; Blaschuk O W; Hales B F
Cadherin mRNAs during rat embryo development in vivo and in vitro.
Teratology 1991;44(5):581-90.
1991: Hales B F; Brown H
The effect of in vivo glutathione depletion with buthionine sulfoximine on rat embryo development.
Teratology 1991;44(3):251-7.
1991: Kapron-Brás C M; Hales B F
Heat-shock induced tolerance to the embryotoxic effects of hyperthermia and cadmium in mouse embryos in vitro.
Teratology 1991;43(1):83-94.
1990: Hales B F; Robaire B
Reversibility of the effects of chronic paternal exposure to cyclophosphamide on pregnancy outcome in rats.
Mutation research 1990;229(2):129-34.
1989: Hales B F
Effects of phosphoramide mustard and acrolein, cytotoxic metabolites of cyclophosphamide, on mouse limb development in vitro.
Teratology 1989;40(1):11-20.
1989: Hales B F; Ludeman S M; Boyd V L
Embryotoxicity of phenyl ketone analogs of cyclophosphamide.
Teratology 1989;39(1):31-7.
1988: Slott V L; Hales B F
Role of the 4-hydroxy intermediate in the in vitro embryotoxicity of cyclophosphamide and dechlorocyclophosphamide.
Toxicology and applied pharmacology 1988;92(2):170-8.
1987: Robaire B; Duron J; Hales B F
Effect of estradiol-filled polydimethylsiloxane subdermal implants in adult male rats on the reproductive system, fertility, and progeny outcome.
Biology of reproduction 1987;37(2):327-34.
1987: Trasler J M; Hales B F; Robaire B
A time-course study of chronic paternal cyclophosphamide treatment in rats: effects on pregnancy outcome and the male reproductive and hematologic systems.
Biology of reproduction 1987;37(2):317-26.
1987: Slott V L; Hales B F
Protection of rat embryos in culture against the embryotoxicity of acrolein using exogenous glutathione.
Biochemical pharmacology 1987;36(13):2187-94.
1987: Slott V L; Hales B F
Enhancement of the embryotoxicity of acrolein, but not phosphoramide mustard, by glutathione depletion in rat embryos in vitro.
Biochemical pharmacology 1987;36(12):2019-25.
1987: Slott V L; Hales B F
Effect of glutathione depletion by buthionine sulfoximine on rat embryonic development in vitro.
Biochemical pharmacology 1987;36(5):683-8.
1987: Hales B F; Slott V L
The role of reactive metabolites in drug-induced teratogenesis.
Progress in clinical and biological research 1987;253():181-91.
1986: Slott V L; Hales B F
The embryolethality and teratogenicity of acrolein in cultured rat embryos.
Teratology 1986;34(2):155-63.
1986: Slott V L; Hales B F
Sodium 2-mercaptoethane sulfonate protection against cyclophosphamide-induced teratogenicity in rats.
Toxicology and applied pharmacology 1986;82(1):80-6.
1985: Slott V L; Hales B F
Teratogenicity and embryolethality of acrolein and structurally related compounds in rats.
Teratology 1985;32(1):65-72.

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