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Nicholas Hales

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Roselle L Cripps; Lucy R Green; John Thompson; Malgorzata S Martin-Gronert; Melanie Monk; I Martin Sheldon; Mark A Hanson; C Nicholas Hales; Susan E Ozanne
The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring.
Jane L Tarry-Adkins; Jaap A Joles; Jian-Hua Chen; Malgorzata S Martin-Gronert; Dionne M van der Giezen; roel goldschmeding; C Nicholas Hales; Susan E Ozanne
Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression.
Steen B Haugaard; Ove Andersen; Ian Halsall; Johan Iversen; C Nicholas Hales; Sten Madsbad
Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution.

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2008: Roselle L Cripps; Lucy R Green; John Thompson; Malgorzata S Martin-Gronert; Melanie Monk; I Martin Sheldon; Mark A Hanson; C Nicholas Hales; Susan E Ozanne
The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring.
Reproductive sciences (Thousand Oaks, Calif.) 2008;15(5):448-56.
2007: Jane L Tarry-Adkins; Jaap A Joles; Jian-Hua Chen; Malgorzata S Martin-Gronert; Dionne M van der Giezen; roel goldschmeding; C Nicholas Hales; Susan E Ozanne
Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R1259-66.
2007: Steen B Haugaard; Ove Andersen; Ian Halsall; Johan Iversen; C Nicholas Hales; Sten Madsbad
Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution.
Metabolism: clinical and experimental 2007;56(7):939-46.
2007: Jian-Hua Chen; Susan E Ozanne; C Nicholas Hales
Methods of cellular senescence induction using oxidative stress.
Methods in molecular biology (Clifton, N.J.) 2007;371():179-89.
2006: Steen B Haugaard; Ove Andersen; C Nicholas Hales; Ian Halsall; A M Rosenfalck; Johan Iversen; Sten Madsbad
Hyperproinsulinaemia in normoglycaemic lipodystrophic HIV-infected patients.
European journal of clinical investigation 2006;36(6):436-45.
2006: Jane L Tarry-Adkins; Susan E Ozanne; Anthony Norden; Hanane Cherif; C Nicholas Hales
Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity.
American journal of physiology. Renal physiology 2006;290(2):F509-16.
2006: Clive J Petry; Bridget J Jennings; Lynwen A James; C Nicholas Hales; Susan E Ozanne
Suckling a protein-restricted rat dam leads to diminished albuminuria in her male offspring in adult life: a longitudinal study.
BMC nephrology 2006;7():14.
2005: Jian-Hua Chen; Susan E Ozanne; C Nicholas Hales
Analysis of expression of growth factor receptors in replicatively and oxidatively senescent human fibroblasts.
FEBS letters 2005;579(28):6388-94.
2005: Jian-Hua Chen; Susan E Ozanne; C Nicholas Hales
Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycle.
DNA repair 2005;4(10):1140-8.
2005: Denise S Fernandez-Twinn; A Wayman; Sofia Ekizoglou; M S Martin; C Nicholas Hales; Susan E Ozanne
Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(2):R368-73.
2004: Jian-Hua Chen; Kai Stoeber; Sarah Kingsbury; Susan E Ozanne; Gareth H Williams; C Nicholas Hales
Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts.
The Journal of biological chemistry 2004;279(47):49439-46.
2004: Gareth H Williams; Robert Swinn; A Toby Prevost; P De Clive-Lowe; Ian Halsall; James J Going; C Nicholas Hales; Kai Stoeber; S J Middleton
Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates.
British journal of cancer 2004;91(4):714-9.
2004: NB Holdstock; V L Allen; Malcolm R Bloomfield; C Nicholas Hales; Abigail Fowden
Development of insulin and proinsulin secretion in newborn pony foals.
The Journal of endocrinology 2004;181(3):469-76.
2004: Ken K Ong; Clive J Petry; P M Emmett; M S Sandhu; Wieland Kiess; C Nicholas Hales; Andy R Ness; David D Dunger
Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels.
Diabetologia 2004;47(6):1064-70.
2004: Susan E Ozanne; Denise S Fernandez-Twinn; C Nicholas Hales
Fetal growth and adult diseases.
Seminars in perinatology 2004;28(1):81-7.
2004: Susan E Ozanne; Rohan Lewis; Bridget J Jennings; C Nicholas Hales
Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet.
Clinical science (London, England : 1979) 2004;106(2):141-5.
2004: Susan E Ozanne; C Nicholas Hales
Lifespan: catch-up growth and obesity in male mice.
Nature 2004;427(6973):411-2.
2003: Denise S Fernandez-Twinn; Susan E Ozanne; Sofia Ekizoglou; C Doherty; L James; B Gusterson; C Nicholas Hales
The maternal endocrine environment in the low-protein model of intra-uterine growth restriction.
The British journal of nutrition 2003;90(4):815-22.
2003: S J M Lisle; Rohan M Lewis; Clive J Petry; Susan E Ozanne; C Nicholas Hales; Alison J Forhead
Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring.
The British journal of nutrition 2003;90(1):33-9.
2003: C Nicholas Hales; Susan E Ozanne
For debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure.
Diabetologia 2003;46(7):1013-9.
2003: Robert S Lindsay; James D Walker; Ian Halsall; C Nicholas Hales; Andrew A Calder; Barbara A Hamilton; Frank D Johnstone
Insulin and insulin propeptides at birth in offspring of diabetic mothers.
The Journal of clinical endocrinology and metabolism 2003;88(4):1664-71.
2003: C Nicholas Hales; Susan E Ozanne
The dangerous road of catch-up growth.
The Journal of physiology 2003;547(Pt 1):5-10.
2002: Susan E Ozanne; C Nicholas Hales
Early programming of glucose-insulin metabolism.
Trends in endocrinology and metabolism: TEM 2002;13(9):368-73.
2002: Rohan M Lewis; Alison J Forhead; Clive J Petry; Susan E Ozanne; C Nicholas Hales
Long-term programming of blood pressure by maternal dietary iron restriction in the rat.
The British journal of nutrition 2002;88(3):283-90.
2002: Kai Stoeber; Robert Swinn; A Toby Prevost; Pamela de Clive-Lowe; Ian Halsall; Stephen M Dilworth; Jackie Marr; William H Turner; Nigel Bullock; Andrew Doble; C Nicholas Hales; Gareth H Williams
Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.
Journal of the National Cancer Institute 2002;94(14):1071-9.
2001: Clive J Petry; Susan E Ozanne; C Nicholas Hales
Programming of intermediary metabolism.
Molecular and cellular endocrinology 2001;185(1-2):81-91.
2001: P Maison; Christopher D Byrne; C Nicholas Hales; Nicholas E Day; Nicholas J Wareham
Do different dimensions of the metabolic syndrome change together over time? Evidence supporting obesity as the central feature.
Diabetes care 2001;24(10):1758-63.
2001: CL Loizou; Susan E Ozanne; ND Martensz; Clive J Petry; CL Wang; C Nicholas Hales
Early growth restriction, membrane phospholipid fatty acid composition, and insulin sensitivity.
Metabolism: clinical and experimental 2001;50(9):1070-7.
2001: Rohan M Lewis; C B Doherty; Lynwen A James; G J Burton; C Nicholas Hales
Effects of maternal iron restriction on placental vascularization in the rat.
Placenta 2001;22(6):534-9.
2001: Rohan M Lewis; Clive J Petry; Susan E Ozanne; C Nicholas Hales
Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring.
Metabolism: clinical and experimental 2001;50(5):562-7.
2001: Rohan M Lewis; Lynwen A James; J Zhang; Christopher D Byrne; C Nicholas Hales
Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels.
The British journal of nutrition 2001;85(2):193-201.
2001: Clive J Petry; MW Dorling; D B Pawlak; Susan E Ozanne; C Nicholas Hales
Diabetes in old male offspring of rat dams fed a reduced protein diet.
International journal of experimental diabetes research 2001;2(2):139-43.
2001: C Nicholas Hales; D J Barker
The thrifty phenotype hypothesis.
British medical bulletin 2001;60():5-20.
2000: Bridget J Jennings; Susan E Ozanne; C Nicholas Hales
Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging?
Molecular genetics and metabolism 2000;71(1-2):32-42.
2000: Halsall David; ND Martensz; J Luan; P Maison; Nicholas J Wareham; C Nicholas Hales; Christopher D Byrne
A common apolipoprotein B signal peptide polymorphism modifies the relation between plasma non-esterified fatty acids and triglyceride concentration in men.
Atherosclerosis 2000;152(1):9-17.
2000: Mary S Fewtrell; C Doherty; Tim J Cole; M Stafford; C Nicholas Hales; A Lucas
Effects of size at birth, gestational age and early growth in preterm infants on glucose and insulin concentrations at 9-12 years.
Diabetologia 2000;43(6):714-7.
2000: P Maison; Christopher D Byrne; C Nicholas Hales; Nicholas J Wareham
Hypertension and its treatment influence changes in fasting nonesterified fatty acid concentrations: a link between the sympathetic nervous system and the metabolic syndrome?
Metabolism: clinical and experimental 2000;49(1):81-7.
1999: Christopher D Byrne; P Maison; Halsall David; ND Martensz; C Nicholas Hales; Nicholas J Wareham
Cross-sectional but not longitudinal associations between non-esterified fatty acid levels and glucose intolerance and other features of the metabolic syndrome.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(12):1007-15.
1999: Susan E Ozanne; C Nicholas Hales
The long-term consequences of intra-uterine protein malnutrition for glucose metabolism.
The Proceedings of the Nutrition Society 1999;58(3):615-9.
1999: CL Loizou; Susan E Ozanne; C Nicholas Hales
The effect of insulin on delta5 desaturation in hepG2 human hepatoma cells and L6 rat muscle myoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 1999;61(2):89-95.
1999: Bridget J Jennings; Susan E Ozanne; MW Dorling; C Nicholas Hales
Early growth determines longevity in male rats and may be related to telomere shortening in the kidney.
FEBS letters 1999;448(1):4-8.
1999: Nicholas J Wareham; Christopher D Byrne; R Williams; Nicholas E Day; C Nicholas Hales
Fasting proinsulin concentrations predict the development of type 2 diabetes.
Diabetes care 1999;22(2):262-70.
1998: Susan E Ozanne; CL Wang; Clive J Petry; J M Smith; C Nicholas Hales
Ketosis resistance in the male offspring of protein-malnourished rat dams.
Metabolism: clinical and experimental 1998;47(12):1450-4.
1998: Susan E Ozanne; ND Martensz; Clive J Petry; CL Loizou; C Nicholas Hales
Maternal low protein diet in rats programmes fatty acid desaturase activities in the offspring.
Diabetologia 1998;41(11):1337-42.
1998: Nicholas J Wareham; Susie Hennings; Christopher D Byrne; C Nicholas Hales; Andrew M Prentice; Nicholas E Day
A quantitative analysis of the relationship between habitual energy expenditure, fitness and the metabolic cardiovascular syndrome.
The British journal of nutrition 1998;80(3):235-41.
1998: Susan E Ozanne; C Nicholas Hales
Thrifty yes, genetic no.
Diabetologia 1998;41(4):485-7.
1997: C Nicholas Hales
Metabolic consequences of intrauterine growth retardation.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1997;423():184-7; discussion 188.
1997: Christopher D Byrne; Nicholas J Wareham; David Phillips; C Nicholas Hales; ND Martensz
Is an exaggerated postprandial triglyceride response associated with the component features of the insulin resistance syndrome?
Diabetic medicine : a journal of the British Diabetic Association 1997;14(11):942-50.
1997: M Desai; C D Byrne; Karim Meeran; N D Martenz; S R Bloom; C Nicholas Hales
Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet.
The American journal of physiology 1997;273(4 Pt 1):G899-904.
1997: Nicholas J Wareham; Christopher D Byrne; C Carr; Nicholas E Day; B J Boucher; C Nicholas Hales
Glucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality.
Metabolism: clinical and experimental 1997;46(10):1171-7.
1997: Clive J Petry; Susan E Ozanne; CL Wang; C Nicholas Hales
Early protein restriction and obesity independently induce hypertension in 1-year-old rats.
Clinical science (London, England : 1979) 1997;93(2):147-52.
1997: C Nicholas Hales
Fetal and infant growth and impaired glucose tolerance in adulthood: the "thrifty phenotype" hypothesis revisited.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1997;422():73-7.
1997: Peter R Shepherd; N J Crowther; M Desai; C Nicholas Hales; Susan E Ozanne
Altered adipocyte properties in the offspring of protein malnourished rats.
The British journal of nutrition 1997;78(1):121-9.
1997: M Desai; C D Byrne; J Zhang; Clive J Petry; A Lucas; C Nicholas Hales
Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet.
The American journal of physiology 1997;272(5 Pt 1):G1083-90.
1997: M Desai; C Nicholas Hales
Role of fetal and infant growth in programming metabolism in later life.
Biological reviews of the Cambridge Philosophical Society 1997;72(2):329-48.
1997: Clive J Petry; M Desai; Susan E Ozanne; C Nicholas Hales
Early and late nutritional windows for diabetes susceptibility.
The Proceedings of the Nutrition Society 1997;56(1B):233-42.
1997: C Nicholas Hales; M Desai; Susan E Ozanne
The Thrifty Phenotype hypothesis: how does it look after 5 years?
Diabetic medicine : a journal of the British Diabetic Association 1997;14(3):189-95.
1997: J Zhang; M Desai; Susan E Ozanne; C Doherty; C Nicholas Hales; C D Byrne
Two variants of quantitative reverse transcriptase PCR used to show differential expression of alpha-, beta- and gamma-fibrinogen genes in rat liver lobes.
The Biochemical journal 1997;321 ( Pt 3)():769-75.
1997: C Nicholas Hales
Non-insulin-dependent diabetes mellitus.
British medical bulletin 1997;53(1):109-22.
1996: Nicholas J Wareham; E M Ness; Christopher D Byrne; BD Cox; Nicholas E Day; C Nicholas Hales
Cigarette smoking is not associated with hyperinsulinemia: evidence against a causal relationship between smoking and insulin resistance.
Metabolism: clinical and experimental 1996;45(12):1551-6.
1996: Christopher D Byrne; Nicholas J Wareham; P K Mistry; David Phillips; ND Martensz; Halsall David; P J Talmud; S E Humphries; C Nicholas Hales
The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide.
Atherosclerosis 1996;127(1):35-42.
1996: M Desai; N J Crowther; A Lucas; C Nicholas Hales
Organ-selective growth in the offspring of protein-restricted mothers.
The British journal of nutrition 1996;76(4):591-603.
1996: M B Cooper; K C Tan; C Nicholas Hales; D John Betteridge
Postprandial lipid metabolism and beta-cell function in non-insulin-dependent (type 2) diabetes mellitus after a mixed meal with a high fat content.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(9):816-27.
1996: C Nicholas Hales; M Desai; Susan E Ozanne; N J Crowther
Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis.
Biochemical Society transactions 1996;24(2):341-50.
1996: Susan E Ozanne; GD Smith; J Tikerpae; C Nicholas Hales
Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams.
The American journal of physiology 1996;270(4 Pt 1):E559-64.
1996: K Lee; Raheela N Khan; I C Rowe; Susan E Ozanne; A C Hall; E Papadakis; C Nicholas Hales; Michael L J Ashford
Ciclazindol inhibits ATP-sensitive K+ channels and stimulates insulin secretion in CR1-G1 insulin-secreting cells.
Molecular pharmacology 1996;49(4):715-20.
1995: Christopher D Byrne; Nicholas J Wareham; Nicholas E Day; R McLeish; D R Williams; C Nicholas Hales
Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance.
Diabetologia 1995;38(11):1358-66.
1995: Nicholas J Wareham; Christopher D Byrne; C Nicholas Hales
Role of insulin and proinsulin in diabetic vascular disease.
Metabolism: clinical and experimental 1995;44(10 Suppl 4):76-82.
1995: Vincenzina Reale; C Nicholas Hales; Michael L J Ashford
Regulation of calcium-activated nonselective cation channel activity by cyclic nucleotides in the rat insulinoma cell line, CRI-G1.
The Journal of membrane biology 1995;145(3):267-78.
1995: M Desai; N J Crowther; Susan E Ozanne; A Lucas; C Nicholas Hales
Adult glucose and lipid metabolism may be programmed during fetal life.
Biochemical Society transactions 1995;23(2):331-5.
1995: Diane Ostrega; Kenneth S Polonsky; Dinesh Nagi; John S Yudkin; L J Cox; P M Clark; C Nicholas Hales
Measurement of proinsulin and intermediates. Validation of immunoassay methods by high-performance liquid chromatography.
Diabetes 1995;44(4):437-40.
1995: Susan E Ozanne; P C Guest; John C Hutton; C Nicholas Hales
Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells.
Diabetologia 1995;38(3):277-82.
1995: K C Tan; M B Cooper; K L Ling; B A Griffin; D J Freeman; C J Packard; J Shepherd; C Nicholas Hales; D John Betteridge
Fasting and postprandial determinants for the occurrence of small dense LDL species in non-insulin-dependent diabetic patients with and without hypertriglyceridaemia: the involvement of insulin, insulin precursor species and insulin resistance.
Atherosclerosis 1995;113(2):273-87.
1995: D R Williams; Nicholas J Wareham; D C Brown; Christopher D Byrne; P M Clark; BD Cox; L J Cox; Nicholas E Day; C Nicholas Hales; Christopher R Palmer
Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project.
Diabetic medicine : a journal of the British Diabetic Association 1995;12(1):30-5.
1994: Vincenzina Reale; C Nicholas Hales; Michael L J Ashford
The effects of pyridine nucleotides on the activity of a calcium-activated nonselective cation channel in the rat insulinoma cell line, CRI-G1.
The Journal of membrane biology 1994;142(3):299-307.
1994: C Nicholas Hales
The pathogenesis of NIDDM.
Diabetologia 1994;37 Suppl 2():S162-8.
1994: Christopher D Byrne; Nicholas J Wareham; D C Brown; P M Clark; L J Cox; Nicholas E Day; Christopher R Palmer; T W Wang; D R Williams; C Nicholas Hales
Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids.
Diabetologia 1994;37(9):889-96.
1994: Vincenzina Reale; C Nicholas Hales; Michael L J Ashford
Nucleotide Regulation of a calcium-activated cation channel in the rat insulinoma cell line, CRI-G1.
The Journal of membrane biology 1994;141(2):101-12.
1994: K Lee; Susan E Ozanne; I C Rowe; C Nicholas Hales; Michael L J Ashford
The effects of trypsin on ATP-sensitive potassium channel properties and sulfonylurea receptors in the CRI-G1 insulin-secreting cell line.
Molecular pharmacology 1994;46(1):176-85.
1994: P M Clark; C Nicholas Hales
How to measure plasma insulin.
Diabetes/metabolism reviews 1994;10(2):79-90.
1994: K Lee; Susan E Ozanne; C Nicholas Hales; Michael L J Ashford
Effects of chemical modification of amino and sulfhydryl groups on KATP channel function and sulfonylurea binding in CRI-G1 insulin-secreting cells.
The Journal of membrane biology 1994;139(3):167-81.
1994: T W Wang; Christopher D Byrne; C Nicholas Hales
Effect of ethanol on hepatic apolipoprotein B synthesis and secretion in vitro.
Biochimica et biophysica acta 1994;1211(2):234-8.
1994: K Lee; Susan E Ozanne; C Nicholas Hales; Michael L J Ashford
Mg(2+)-dependent inhibition of KATP by sulphonylureas in CRI-G1 insulin-secreting cells.
British journal of pharmacology 1994;111(2):632-40.
1993: P Newsholme; A A Adogu; Maria A Soos; C Nicholas Hales
Complement-induced Ca2+ influx in cultured fibroblasts is decreased by the calcium-channel antagonist nifedipine or by some bivalent inorganic cations.
The Biochemical journal 1993;295 ( Pt 3)():773-9.
1993: Raheela N Khan; C Nicholas Hales; Susan E Ozanne; A A Adogu; Michael L J Ashford
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11.
Proceedings. Biological sciences / The Royal Society 1993;253(1338):225-31.
1993: I Hamdi; M Green; J M Shneerson; Christopher R Palmer; C Nicholas Hales
Proinsulin, proinsulin intermediate and insulin in cystic fibrosis.
Clinical endocrinology 1993;39(1):21-6.
1992: Christopher D Byrne; T W Wang; C Nicholas Hales
Control of Hep G2-cell triacylglycerol and apolipoprotein B synthesis and secretion by polyunsaturated non-esterified fatty acids and insulin.
The Biochemical journal 1992;288 ( Pt 1)():101-7.
1992: C Nicholas Hales; D J Barker
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.
Diabetologia 1992;35(7):595-601.
1992: R Temple; P M Clark; C Nicholas Hales
Measurement of insulin secretion in type 2 diabetes: problems and pitfalls.
Diabetic medicine : a journal of the British Diabetic Association 1992;9(6):503-12.
1992: P M Clark; Jonathan C Levy; L Cox; M Burnett; RC Turner; C Nicholas Hales
Immunoradiometric assay of insulin, intact proinsulin and 32-33 split proinsulin and radioimmunoassay of insulin in diet-treated type 2 (non-insulin-dependent) diabetic subjects.
Diabetologia 1992;35(5):469-74.
1992: B Alpha; L Cox; N Crowther; P M Clark; C Nicholas Hales
Sensitive amplified immunoenzymometric assays (IEMA) for human insulin and intact proinsulin.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1992;30(1):27-32.
1991: Christopher D Byrne; N P Brindle; T W Wang; C Nicholas Hales
Interaction of non-esterified fatty acid and insulin in control of triacylglycerol secretion by Hep G2 cells.
The Biochemical journal 1991;280 ( Pt 1)():99-104.
1991: C Nicholas Hales; D J Barker; P M Clark; L J Cox; Caroline H D Fall; C Osmond; P D Winter
Fetal and infant growth and impaired glucose tolerance at age 64.
BMJ (Clinical research ed.) 1991;303(6809):1019-22.
1991: D R Williams; C Byrne; P M Clark; L Cox; Nicholas E Day; G Rayman; T Wang; C Nicholas Hales
Raised proinsulin concentration as early indicator of beta cell dysfunction.
BMJ (Clinical research ed.) 1991;303(6794):95-6.
1991: D C Brown; Christopher D Byrne; P M Clark; BD Cox; Nicholas E Day; C Nicholas Hales; J R Shackleton; T W Wang; D R Williams
Height and glucose tolerance in adult subjects.
Diabetologia 1991;34(7):531-3.
1991: R Z Kozlowski; N C Sturgess; C Nicholas Hales; Michael L J Ashford
Voltage-activated currents in the CRI-G1 rat insulin-secreting cell-line.
Comparative biochemistry and physiology. A, Comparative physiology 1991;100(3):613-21.
1990: G Rayman; P Clark; A E Schneider; C Nicholas Hales
The first phase insulin response to intravenous glucose is highly reproducible.
Diabetologia 1990;33(10):631-4.
1990: Dinesh Nagi; T J Hendra; A J Ryle; T M Cooper; R C Temple; P M Clark; A E Schneider; C Nicholas Hales; John S Yudkin
The relationships of concentrations of insulin, intact proinsulin and 32-33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects.
Diabetologia 1990;33(9):532-7.
1990: R C Temple; P M Clark; Dinesh Nagi; A E Schneider; John S Yudkin; C Nicholas Hales
Radioimmunoassay may overestimate insulin in non-insulin-dependent diabetics.
Clinical endocrinology 1990;32(6):689-93.
1990: S F Beer; S O'Rahilly; R S Spivey; C Nicholas Hales; R C Turner
Plasma proinsulin in first-degree relatives of type 2 diabetic subjects.
Diabetes research (Edinburgh, Scotland) 1990;14(2):51-4.
1989: R Z Kozlowski; C Nicholas Hales; Michael L J Ashford
Dual effects of diazoxide on ATP-K+ currents recorded from an insulin-secreting cell line.
British journal of pharmacology 1989;97(4):1039-50.
1989: S F Beer; J H Parr; R C Temple; C Nicholas Hales
The effect of thyroid disease on proinsulin and C-peptide levels.
Clinical endocrinology 1989;30(4):379-83.
1989: R C Temple; C A Carrington; S D Luzio; D R Owens; A E Schneider; W J Sobey; C Nicholas Hales
Insulin deficiency in non-insulin-dependent diabetes.
Lancet 1989;1(8633):293-5.
1989: S F Beer; P M Bircham; S R Bloom; P M Clark; C Nicholas Hales; C M Hughes; C T Jones; D R Marsh; P R Raggatt; A L Findlay
The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women.
The Journal of endocrinology 1989;120(2):337-50.
1988: N C Sturgess; R Z Kozlowski; C A Carrington; C Nicholas Hales; Michael L J Ashford
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line.
British journal of pharmacology 1988;95(1):83-94.
1988: Michael L J Ashford; N C Sturgess; N J Trout; N J Gardner; C Nicholas Hales
Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones.
Pflügers Archiv : European journal of physiology 1988;412(3):297-304.
1987: N C Sturgess; C A Carrington; C Nicholas Hales; Michael L J Ashford
Nucleotide-sensitive ion channels in human insulin producing tumour cells.
Pflügers Archiv : European journal of physiology 1987;410(1-2):169-72.
1987: N C Sturgess; C Nicholas Hales; Michael L J Ashford
Calcium and ATP regulate the activity of a non-selective cation channel in a rat insulinoma cell line.
Pflügers Archiv : European journal of physiology 1987;409(6):607-15.
1986: N C Sturgess; C Nicholas Hales; Michael L J Ashford
Inhibition of a calcium-activated, non-selective cation channel, in a rat insulinoma cell line, by adenine derivatives.
FEBS letters 1986;208(2):397-400.
1986: N C Sturgess; Michael L J Ashford; C A Carrington; C Nicholas Hales
Single channel recordings of potassium currents in an insulin-secreting cell line.
The Journal of endocrinology 1986;109(2):201-7.
1986: Michael L J Ashford; N C Sturgess; D L Cook; C Nicholas Hales
K-channels in an insulin-secreting cell line: effects of ATP and sulphonylureas.
Advances in experimental medicine and biology 1986;211():69-76.
1985: N C Sturgess; Michael L J Ashford; D L Cook; C Nicholas Hales
The sulphonylurea receptor may be an ATP-sensitive potassium channel.
Lancet 1985;2(8453):474-5.