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Andrew Halestrap

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Andrew P Halestrap
The SLC16 gene family - structure, role and regulation in health and disease.
Philippe Pasdois; Joanne E Parker; Elinor J Griffiths; Andrew P Halestrap
Hexokinase II and reperfusion injury: TAT-HK2 peptide impairs vascular function in Langendorff-perfused rat hearts.
Markus Schwarzländer; Tobias P Dick; Michael R Duchen; Mark D Fricker; Andrew P Halestrap; David C Logan; Andreas J Meyer; Florian L Müller; Michael P Murphy; Rosario Rizzuto; Lee J Sweetlove
Mitochondrial 'flashes': a radical concept repHined.

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All Publications

2013: Andrew P Halestrap
The SLC16 gene family - structure, role and regulation in health and disease.
Molecular aspects of medicine 2013;34(2-3):337-49.
2013: Philippe Pasdois; Joanne E Parker; Elinor J Griffiths; Andrew P Halestrap
Hexokinase II and reperfusion injury: TAT-HK2 peptide impairs vascular function in Langendorff-perfused rat hearts.
Circulation research 2013;112(2):e3-7.
2012: Markus Schwarzländer; Tobias P Dick; Michael R Duchen; Mark D Fricker; Andrew P Halestrap; David C Logan; Andreas J Meyer; Florian L Müller; Michael P Murphy; Rosario Rizzuto; Lee J Sweetlove
Mitochondrial 'flashes': a radical concept repHined.
Trends in cell biology 2012;22(10):503-8.
2012: Andrew P Halestrap
The mitochondrial pyruvate carrier: has it been unearthed at last?
Cell metabolism 2012;16(2):141-3.
2012: Timothy J Pullen; Erik A Richter; Gao Sun; Lykke Sylow; Andrew P Halestrap; Guy A Rutter
Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.
Diabetes 2012;61(7):1719-25.
2012: Johanna Chiche; Patrick J Cozzone; Laurent Daniel; Frédéric Frassineti; Andrew P Halestrap; Jacques Pouysségur; Christophe Vilmen; Yann Le Fur; Norbert W Lutz
In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.
International journal of cancer. Journal international du cancer 2012;130(7):1511-20.
2012: Keith D Garlid; Andrew P Halestrap
The mitochondrial K(ATP) channel--fact or fiction?
Journal of molecular and cellular cardiology 2012;52(3):578-83.
2012: Pinadda Varanyuwatana; Andrew P Halestrap
The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore.
Mitochondrion 2012;12(1):120-5.
2011: Igor Khaliulin; Andrew P Halestrap; M-Saadeh Suleiman
Temperature preconditioning is optimal at 26° C and confers additional protection to hypothermic cardioplegic ischemic arrest.
Experimental biology and medicine (Maywood, N.J.) 2011;236(6):736-45.
2011: Philippe Pasdois; Joanne E Parker; Elinor J Griffiths; Andrew P Halestrap
The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia.
The Biochemical journal 2011;436(2):493-505.
2011: Laurent Mouchiroud; Laurent Molin; Prasad Kasturi; Mohamed N Triba; Marc-Emmanuel Dumas; Marieangela C Wilson; Andrew P Halestrap; Damien Roussel; Ingrid Masse; Nicolas Dallière; Laurent Ségalat; Marc Billaud; Florence Solari
Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.
Aging cell 2011;10(1):39-54.
2010: Igor Khaliulin; Joanna E Parker; Andrew P Halestrap
Consecutive pharmacological activation of PKA and PKC mimics the potent cardioprotection of temperature preconditioning.
Cardiovascular research 2010;88(2):324-33.
2010: Matthew J Ovens; Christine Manoharan; Marieangela C Wilson; Clarey M Murray; Andrew P Halestrap
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein.
The Biochemical journal 2010;431(2):217-25.
2010: Andrew P Halestrap
A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection.
Biochemical Society transactions 2010;38(4):841-60.
2010: Matthew J Ovens; Andrew J Davies; Marieangela C Wilson; Clare M Murray; Andrew P Halestrap
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
The Biochemical journal 2010;425(3):523-30.
2009: Andrew P Halestrap
Mitochondrial calcium in health and disease.
Biochimica et biophysica acta 2009;1787(11):1289-90.
2009: Andrew P Halestrap; Philippe Pasdois
The role of the mitochondrial permeability transition pore in heart disease.
Biochimica et biophysica acta 2009;1787(11):1402-15.
2009: Marieangela C Wilson; David Meredith; Chotirote Bunnun; Richard B Sessions; Andrew P Halestrap
Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle.
The Journal of biological chemistry 2009;284(30):20011-21.
2009: Andrew P Halestrap
What is the mitochondrial permeability transition pore?
Journal of molecular and cellular cardiology 2009;46(6):821-31.
2009: Andrew P Halestrap
Mitochondria and reperfusion injury of the heart--a holey death but not beyond salvation.
Journal of bioenergetics and biomembranes 2009;41(2):113-21.
2008: Paul S Brookes; Nadeene Parker; Julie A Buckingham; antonio vidal-puig; Andrew P Halestrap; Thomas E Gunter; David G Nicholls; Paolo Bernardi; John J Lemasters; Martin D Brand
UCPs--unlikely calcium porters.
Nature cell biology 2008;10(11):1235-7; author reply 1237-40.
2008: Anna W C Leung; Pinadda Varanyuwatana; Andrew P Halestrap
The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition.
The Journal of biological chemistry 2008;283(39):26312-23.
2008: Anna W C Leung; Andrew P Halestrap
Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore.
Biochimica et biophysica acta 2008;1777(7-8):946-52.
2008: Piotr Bednarczyk; George D Barker; Andrew P Halestrap
Determination of the rate of K(+) movement through potassium channels in isolated rat heart and liver mitochondria.
Biochimica et biophysica acta 2008;1777(6):540-8.
2008: Samantha J Clarke; Igor Khaliulin; Manika Das; Joanne E Parker; Kate J Heesom; Andrew P Halestrap
Inhibition of mitochondrial permeability transition pore opening by ischemic preconditioning is probably mediated by reduction of oxidative stress rather than mitochondrial protein phosphorylation.
Circulation research 2008;102(9):1082-90.
2008: Roger G Ptak; Philippe A Gallay; Dirk Jochmans; Andrew P Halestrap; Urs T Ruegg; Luke A Pallansch; Michael D Bobardt; Marie-Pierre de Bethune; Johan Neyts; Erik De Clercq; Jean-Maurice Dumont; Pietro Scalfaro; Kamel Besseghir; Roland M Wenger; Brigitte Rosenwirth
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.
Antimicrobial agents and chemotherapy 2008;52(4):1302-17.
2007: Timo Otonkoski; Hong Jiao; Nina Kaminen-Ahola; Isabel Tapia-Paez; Mohammed S Ullah; Laura E Parton; Frans Schuit; Roel Quintens; Ilkka Sipilä; Ertan Mayatepek; Thomas Meissner; Andrew P Halestrap; Guy Rutter; Juha Kere
Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells.
American journal of human genetics 2007;81(3):467-74.
2007: Karin Pierre; Annabelle Parent; Pierre-Yves Jayet; Andrew P Halestrap; Urs Scherrer; Luc Pellerin
Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.
The Journal of physiology 2007;583(Pt 2):469-86.
2007: Andrew P Halestrap; Samantha J Clarke; Igor Khaliulin
The role of mitochondria in protection of the heart by preconditioning.
Biochimica et biophysica acta 2007;1767(8):1007-31.
2007: Paul A Townsend; Sean Davidson; Samantha J Clarke; Igor Khaliulin; Christopher J Carroll; Tiziano M. Scarabelli; Richard A Knight; Anastasis Stephanou; David S Latchman; Andrew P Halestrap
Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H928-38.
2007: Igor Khaliulin; Samantha J Clarke; Hua Lin; Joanna Parker; M-Saadeh Suleiman; Andrew P Halestrap
Temperature preconditioning of isolated rat hearts--a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore.
The Journal of physiology 2007;581(Pt 3):1147-61.
2006: Christine Manoharan; Marieangela C Wilson; Richard B Sessions; Andrew P Halestrap
The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity.
Molecular membrane biology 2006;23(6):486-98.
2006: Andrew P Halestrap
Mitochondria and preconditioning: a connexin connection?
Circulation research 2006;99(1):10-2.
2006: Aniko Varadi; A Grant; M McCormack; T Nicolson; M Magistri; Kathryn J Mitchell; Andrew P Halestrap; H Yuan; B Schwappach; Guy A Rutter
Intracellular ATP-sensitive K+ channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis.
Diabetologia 2006;49(7):1567-77.
2006: Mohammed S Ullah; Andrew J Davies; Andrew P Halestrap
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.
The Journal of biological chemistry 2006;281(14):9030-7.
2006: Andrew P Halestrap
Calcium, mitochondria and reperfusion injury: a pore way to die.
Biochemical Society transactions 2006;34(Pt 2):232-7.
2006: Linda Hildegard Bergersen; M Thomas; E Jóhannsson; O Waerhaug; Andrew P Halestrap; K Andersen; Ole M Sejersted; Ole Petter Ottersen
Cross-reinnervation changes the expression patterns of the monocarboxylate transporters 1 and 4: An experimental study in slow and fast rat skeletal muscle.
Neuroscience 2006;138(4):1105-13.
2005: Marieangela C Wilson; David Meredith; Jocelyn E Manning Fox; Christine Manoharan; Andrew J Davies; Andrew P Halestrap
Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).
The Journal of biological chemistry 2005;280(29):27213-21.
2005: Kelvin H H Lim; Andrew P Halestrap; Gianni Angelini; M-Saadeh Suleiman
Propofol is cardioprotective in a clinically relevant model of normothermic blood cardioplegic arrest and cardiopulmonary bypass.
Experimental biology and medicine (Maywood, N.J.) 2005;230(6):413-20.
2005: John C W Hildyard; Carina Ammälä; Iain D Dukes; Stephen A Thomson; Andrew P Halestrap
Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier.
Biochimica et biophysica acta 2005;1707(2-3):221-30.
2005: Luc Pellerin; Linda Hildegard Bergersen; Andrew P Halestrap; Karin Pierre
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain.
Journal of neuroscience research 2005;79(1-2):55-64.
2004: Edith C H Friesema; Annette Grueters; Heike Biebermann; Heiko Krude; Arpad von Moers; Maarten Reeser; Timothy G Barrett; Edna E Mancilla; Johan Svensson; Monique H A Kester; George G J M Kuiper; Sahila Balkassmi; André G Uitterlinden; Josef Koehrle; Patrice Rodien; Andrew P Halestrap; Theo J Visser
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation.
Lancet 2004;364(9443):1435-7.
2004: Andrew P Halestrap
Does the mitochondrial permeability transition have a role in preconditioning?
Circulation 2004;110(11):e303; author reply e303.
2004: Andrew P Halestrap
Mitochondrial permeability: dual role for the ADP/ATP translocator?
Nature 2004;430(7003):1 p following 983.
2004: James G Orr; Val Leel; Gary A Cameron; Carylyn J Marek; Emma L Haughton; Lucy J Elrick; Julie E Trim; Gabrielle M Hawksworth; Andrew P Halestrap; Matthew C Wright
Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells.
Hepatology (Baltimore, Md.) 2004;40(1):232-42.
2004: Andrew P Halestrap; Samantha J Clarke; Sabzali Javadov
Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.
Cardiovascular research 2004;61(3):372-85.
2004: Andrew P Halestrap; David Meredith
The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.
Pflügers Archiv : European journal of physiology 2004;447(5):619-28.
2003: Edith C H Friesema; Sumita Ganguly; Amal Abdalla; Jocelyn E Manning Fox; Andrew P Halestrap; Theo J Visser
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter.
The Journal of biological chemistry 2003;278(41):40128-35.
2003: John C W Hildyard; Andrew P Halestrap
Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae.
The Biochemical journal 2003;374(Pt 3):607-11.
2003: Nicola King; John D McGivan; Elinor J Griffiths; Andrew P Halestrap; M-Saadeh Suleiman
Glutamate loading protects freshly isolated and perfused adult cardiomyocytes against intracellular ROS generation.
Journal of molecular and cellular cardiology 2003;35(8):975-84.
2003: Andrew P Halestrap; Catherine Brenner
The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death.
Current medicinal chemistry 2003;10(16):1507-25.
2003: Sabzali Javadov; Samantha Clarke; Manika Das; Elinor J Griffiths; Kelvin H H Lim; Andrew P Halestrap
Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart.
The Journal of physiology 2003;549(Pt 2):513-24.
2003: Manika Das; Joanne E Parker; Andrew P Halestrap
Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria.
The Journal of physiology 2003;547(Pt 3):893-902.
2003: Amina Rafiki; Jean-Luc Boulland; Andrew P Halestrap; Ole Petter Ottersen; Linda Hildegard Bergersen
Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain.
Neuroscience 2003;122(3):677-88.
2002: Kelvin H H Lim; Sabzali Javadov; Manika Das; Samantha J Clarke; M-Saadeh Suleiman; Andrew P Halestrap
The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.
The Journal of physiology 2002;545(Pt 3):961-74.
2002: Gavin P McStay; Samantha J Clarke; Andrew P Halestrap
Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore.
The Biochemical journal 2002;367(Pt 2):541-8.
2002: Samantha J Clarke; Gavin P McStay; Andrew P Halestrap
Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.
The Journal of biological chemistry 2002;277(38):34793-9.
2002: Robert A Yokel; Marieangela Wilson; Wesley R Harris; Andrew P Halestrap
Aluminum citrate uptake by immortalized brain endothelial cells: implications for its blood-brain barrier transport.
Brain research 2002;930(1-2):101-10.
2002: Andrew P Halestrap; Gavin P McStay; Samantha J Clarke
The permeability transition pore complex: another view.
Biochimie 2002;84(2-3):153-66.
2002: Marieangela C Wilson; David Meredith; Andrew P Halestrap
Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ.
The Journal of biological chemistry 2002;277(5):3666-72.
2002: H Green; Andrew P Halestrap; C Mockett; D O'Toole; S Grant; J Ouyang
Increases in muscle MCT are associated with reductions in muscle lactate after a single exercise session in humans.
American journal of physiology. Endocrinology and metabolism 2002;282(1):E154-60.
2001: A O'Toole; S Kelly Moule; Peter J Lockyer; Andrew P Halestrap
Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308.
The Biochemical journal 2001;359(Pt 1):119-27.
2001: E Jóhannsson; Per Kristian Lunde; Catherine Heddle; Ivar Sjaastad; M J Thomas; Linda Hildegard Bergersen; Andrew P Halestrap; TW Blackstad; Ole Petter Ottersen; Ole M Sejersted
Upregulation of the cardiac monocarboxylate transporter MCT1 in a rat model of congestive heart failure.
Circulation 2001;104(6):729-34.
2001: Linda Hildegard Bergersen; O Waerhaug; J Helm; M Thomas; Petter Laake; A J Davies; M C Wilson; Andrew P Halestrap; Ole Petter Ottersen
A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2001;136(4):523-34.
2001: M-Saadeh Suleiman; Andrew P Halestrap; Elinor J Griffiths
Mitochondria: a target for myocardial protection.
Pharmacology & therapeutics 2001;89(1):29-46.
2000: Jocelyn E Manning Fox; David Meredith; Andrew P Halestrap
Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle.
The Journal of physiology 2000;529 Pt 2():285-93.
2000: Arend Bonen; Mio Tonouchi; Dragana Miskovic; Catherine Heddle; John J Heikkila; Andrew P Halestrap
Isoform-specific regulation of the lactate transporters MCT1 and MCT4 by contractile activity.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1131-8.
2000: P Kirk; Marieangela C Wilson; Catherine Heddle; Marion H Brown; A Neil Barclay; Andrew P Halestrap
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.
The EMBO journal 2000;19(15):3896-904.
2000: Martin R Owen; Elena Doran; Andrew P Halestrap
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
The Biochemical journal 2000;348 Pt 3():607-14.
2000: Arend Bonen; Dragana Miskovic; Mio Tonouchi; Kathleen Lemieux; M C Wilson; André Marette; Andrew P Halestrap
Abundance and subcellular distribution of MCT1 and MCT4 in heart and fast-twitch skeletal muscles.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E1067-77.
2000: Elena Doran; Andrew P Halestrap
Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites.
The Biochemical journal 2000;348 Pt 2():343-50.
2000: Andrew P Halestrap; Elena Doran; JP Gillespie; A O'Toole
Mitochondria and cell death.
Biochemical Society transactions 2000;28(2):170-7.
2000: Sabzali Javadov; Kelvin H H Lim; PM Kerr; M-Saadeh Suleiman; Gianni Angelini; Andrew P Halestrap
Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition.
Cardiovascular research 2000;45(2):360-9.
2000: Andrew P Halestrap; JP Gillespie; A O'Toole; Elena Doran
Mitochondria and cell death: a pore way to die?
Symposia of the Society for Experimental Biology 2000;52():65-80.
1999: Andrew P Halestrap; Nigel T Price
The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.
The Biochemical journal 1999;343 Pt 2():281-99.
1999: Carsten Juel; Andrew P Halestrap
Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter.
The Journal of physiology 1999;517 ( Pt 3)():633-42.
1999: Henriette Pilegaard; G Terzis; Andrew P Halestrap; Carsten Juel
Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle.
The American journal of physiology 1999;276(5 Pt 1):E843-8.
1999: Linda Hildegard Bergersen; E Jóhannsson; Margaret Lin Veruki; Erlend A Nagelhus; Andrew P Halestrap; Ole M Sejersted; Ole Petter Ottersen
Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat.
Neuroscience 1999;90(1):319-31.
1999: PM Kerr; M-Saadeh Suleiman; Andrew P Halestrap
Reversal of permeability transition during recovery of hearts from ischemia and its enhancement by pyruvate.
The American journal of physiology 1999;276(2 Pt 2):H496-502.
1999: Henriette Pilegaard; K Domino; T Noland; Carsten Juel; Ylva Hellsten; Andrew P Halestrap; Jens Bangsbo
Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle.
The American journal of physiology 1999;276(2 Pt 1):E255-61.
1998: KY Woodfield; A Rück; Dieter Brdiczka; Andrew P Halestrap
Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition.
The Biochemical journal 1998;336 ( Pt 2)():287-90.
1998: Andrew P Halestrap; PM Kerr; Sabzali Javadov; KY Woodfield
Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart.
Biochimica et biophysica acta 1998;1366(1-2):79-94.
1998: Marieangela C Wilson; Vicky N Jackson; Catherine Heddle; Nigel T Price; Henriette Pilegaard; Carsten Juel; Arend Bonen; I Montgomery; O F Hutter; Andrew P Halestrap
Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3.
The Journal of biological chemistry 1998;273(26):15920-6.
1998: Nigel T Price; Vicky N Jackson; Andrew P Halestrap
Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.
The Biochemical journal 1998;329 ( Pt 2)():321-8.
1997: Andrew P Halestrap; CP Connern; Elinor J Griffiths; PM Kerr
Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury.
Molecular and cellular biochemistry 1997;174(1-2):167-72.
1997: Andrew P Halestrap; X Wang; RC Poole; Vicky N Jackson; Nigel T Price
Lactate transport in heart in relation to myocardial ischemia.
The American journal of cardiology 1997;80(3A):17A-25A.
1997: K J McCullagh; RC Poole; Andrew P Halestrap; K F Tipton; M O'Brien; A Bonen
Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle.
The American journal of physiology 1997;273(2 Pt 1):E239-46.
1997: RC Poole; Andrew P Halestrap
Interaction of the erythrocyte lactate transporter (monocarboxylate transporter 1) with an integral 70-kDa membrane glycoprotein of the immunoglobulin superfamily.
The Journal of biological chemistry 1997;272(23):14624-8.
1997: B Singh; Andrew P Halestrap; Christos Paraskeva
Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources.
Carcinogenesis 1997;18(6):1265-70.
1997: Vicky N Jackson; Nigel T Price; L Carpenter; Andrew P Halestrap
Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation.
The Biochemical journal 1997;324 ( Pt 2)():447-53.
1997: KY Woodfield; Nigel T Price; Andrew P Halestrap
cDNA cloning of rat mitochondrial cyclophilin.
Biochimica et biophysica acta 1997;1351(1-2):27-30.
1997: Andrew P Halestrap; KY Woodfield; CP Connern
Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase.
The Journal of biological chemistry 1997;272(6):3346-54.
1996: R C Poole; C E Sansom; Andrew P Halestrap
Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1).
The Biochemical journal 1996;320 ( Pt 3)():817-24.
1996: K J McCullagh; R C Poole; Andrew P Halestrap; M O'Brien; A Bonen
Role of the lactate transporter (MCT1) in skeletal muscles.
The American journal of physiology 1996;271(1 Pt 1):E143-50.
1996: C P Connern; Andrew P Halestrap
Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+].
Biochemistry 1996;35(25):8172-80.
1996: L Carpenter; R C Poole; Andrew P Halestrap
Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function.
Biochimica et biophysica acta 1996;1279(2):157-63.
1996: X Wang; AJ Levi; Andrew P Halestrap
Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells.
The American journal of physiology 1996;270(2 Pt 2):H476-84.
1996: Vicky N Jackson; Andrew P Halestrap
The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein.
The Journal of biological chemistry 1996;271(2):861-8.
1995: Vicky N Jackson; Nigel T Price; Andrew P Halestrap
cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle.
Biochimica et biophysica acta 1995;1238(2):193-6.
1995: S L Cranmer; A R Conant; W E Gutteridge; Andrew P Halestrap
Characterization of the enhanced transport of L- and D-lactate into human red blood cells infected with Plasmodium falciparum suggests the presence of a novel saturable lactate proton cotransporter.
The Journal of biological chemistry 1995;270(25):15045-52.
1995: Elinor J Griffiths; Andrew P Halestrap
Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion.
The Biochemical journal 1995;307 ( Pt 1)():93-8.
1994: L Carpenter; Andrew P Halestrap
The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF.
The Biochemical journal 1994;304 ( Pt 3)():751-60.
1994: R C Poole; Andrew P Halestrap
N-terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned monocarboxylate transport protein MCT1.
The Biochemical journal 1994;303 ( Pt 3)():755-9.
1994: X Wang; AJ Levi; Andrew P Halestrap
Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pHi.
The American journal of physiology 1994;267(5 Pt 2):H1759-69.
1994: C P Connern; Andrew P Halestrap
Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel.
The Biochemical journal 1994;302 ( Pt 2)():321-4.
1994: Andrew P Halestrap
Regulation of mitochondrial metabolism through changes in matrix volume.
Biochemical Society transactions 1994;22(2):522-9.
1993: Elinor J Griffiths; Andrew P Halestrap
Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.
Journal of molecular and cellular cardiology 1993;25(12):1461-9.
1993: Andrew P Halestrap; Elinor J Griffiths; C P Connern
Mitochondrial calcium handling and oxidative stress.
Biochemical Society transactions 1993;21(2):353-8.
1993: R C Poole; N J Bowden; Andrew P Halestrap
Derivatives of cinnamic acid interact with the nucleotide binding site of mitochondrial aldehyde dehydrogenase. Effects on the dehydrogenase reaction and stimulation of esterase activity by nucleotides.
Biochemical pharmacology 1993;45(8):1621-30.
1993: M R Owen; Andrew P Halestrap
The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis.
Biochimica et biophysica acta 1993;1142(1-2):11-22.
1993: R C Poole; Andrew P Halestrap
Transport of lactate and other monocarboxylates across mammalian plasma membranes.
The American journal of physiology 1993;264(4 Pt 1):C761-82.
1993: U Schneider; R C Poole; Andrew P Halestrap; Peter Grafe
Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots.
Neuroscience 1993;53(4):1153-62.
1993: Elinor J Griffiths; Andrew P Halestrap
Pyrophosphate metabolism in the perfused heart and isolated heart mitochondria and its role in regulation of mitochondrial function by calcium.
The Biochemical journal 1993;290 ( Pt 2)():489-95.
1993: X Wang; R C Poole; Andrew P Halestrap; AJ Levi
Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells.
The Biochemical journal 1993;290 ( Pt 1)():249-58.
1993: S W Young; R C Poole; A T Hudson; Andrew P Halestrap; Richard M Denton; Jeremy M Tavaré
Effects of tyrosine kinase inhibitors on protein kinase-independent systems.
FEBS letters 1993;316(3):278-82.
1992: C P Connern; Andrew P Halestrap
Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin.
The Biochemical journal 1992;284 ( Pt 2)():381-5.
1992: R C Poole; Andrew P Halestrap
Identification and partial purification of the erythrocyte L-lactate transporter.
The Biochemical journal 1992;283 ( Pt 3)():855-62.
1991: R C Poole; S L Cranmer; D W Holdup; Andrew P Halestrap
Inhibition of L-lactate transport and band 3-mediated anion transport in erythrocytes by the novel stilbenedisulphonate N,N,N',N'-tetrabenzyl-4,4'-diaminostilbene-2,2'-disulpho nat e (TBenzDS).
Biochimica et biophysica acta 1991;1070(1):69-76.
1991: Andrew P Halestrap
Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage.
The Biochemical journal 1991;278 ( Pt 3)():715-9.
1991: R C Poole; Andrew P Halestrap
Reversible and irreversible inhibition, by stilbenedisulphonates, of lactate transport into rat erythrocytes. Identification of some new high-affinity inhibitors.
The Biochemical journal 1991;275 ( Pt 2)():307-12.
1991: Elinor J Griffiths; Andrew P Halestrap
Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin.
The Biochemical journal 1991;274 ( Pt 2)():611-4.
1990: R C Poole; Andrew P Halestrap
Inhibition and labelling of the erythrocyte lactate transporter by stilbene disulphonates.
Biochemical Society transactions 1990;18(6):1245-6.
1990: Andrew P Halestrap; R C Poole; S L Cranmer
Mechanisms and regulation of lactate, pyruvate and ketone body transport across the plasma membrane of mammalian cells and their metabolic consequences.
Biochemical Society transactions 1990;18(6):1132-5.
1990: R C Poole; S L Cranmer; Andrew P Halestrap; AJ Levi
Substrate and inhibitor specificity of monocarboxylate transport into heart cells and erythrocytes. Further evidence for the existence of two distinct carriers.
The Biochemical journal 1990;269(3):827-9.
1990: A M Davidson; Andrew P Halestrap
Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms.
The Biochemical journal 1990;268(1):147-52.
1990: Andrew P Halestrap; A M Davidson
Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase.
The Biochemical journal 1990;268(1):153-60.
1989: R C Poole; Andrew P Halestrap; S J Price; AJ Levi
The kinetics of transport of lactate and pyruvate into isolated cardiac myocytes from guinea pig. Kinetic evidence for the presence of a carrier distinct from that in erythrocytes and hepatocytes.
The Biochemical journal 1989;264(2):409-18.
1989: R C Poole; Andrew P Halestrap
Purification of aldehyde dehydrogenase from rat liver mitochondria by alpha-cyanocinnamate affinity chromatography.
The Biochemical journal 1989;259(1):105-10.
1989: Andrew P Halestrap
The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism.
Biochimica et biophysica acta 1989;973(3):355-82.
1989: A M Davidson; Andrew P Halestrap
Inhibition of mitochondrial-matrix inorganic pyrophosphatase by physiological [Ca2+], and its role in the hormonal regulation of mitochondrial matrix volume.
The Biochemical journal 1989;258(3):817-21.
1988: R C Poole; Andrew P Halestrap
Reconstitution of the L-lactate carrier from rat and rabbit erythrocyte plasma membranes.
The Biochemical journal 1988;254(2):385-90.
1988: A M Davidson; Andrew P Halestrap
Inorganic pyrophosphate is located primarily in the mitochondria of the hepatocyte and increases in parallel with the decrease in light-scattering induced by gluconeogenic hormones, butyrate and ionophore A23187.
The Biochemical journal 1988;254(2):379-84.
1988: G L Edlund; Andrew P Halestrap
The kinetics of transport of lactate and pyruvate into rat hepatocytes. Evidence for the presence of a specific carrier similar to that in erythrocytes.
The Biochemical journal 1988;249(1):117-26.
1987: H J Pryor; J E Smyth; P T Quinlan; Andrew P Halestrap
Evidence that the flux control coefficient of the respiratory chain is high during gluconeogenesis from lactate in hepatocytes from starved rats. Implications for the hormonal control of gluconeogenesis and action of hypoglycaemic agents.
The Biochemical journal 1987;247(2):449-57.
1987: A M Davidson; Andrew P Halestrap
Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content.
The Biochemical journal 1987;246(3):715-23.
1987: Andrew P Halestrap
The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+.
The Biochemical journal 1987;244(1):159-64.