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James Edwin Hall

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Zhuo Wang; Xiaohua Zhu; Anuradha Srivastava; Qiang Liu; J Mark Sweat; Trupti Pandharkar; Chad E Stephens; Ed Riccio; Toufan Parman; Manoj Munde; Swati Mandal; Rentala Madhubala; Richard R Tidwell; W David Wilson; David W Boykin; James Edwin Hall; Dennis E Kyle; Karl A Werbovetz
Novel arylimidamides for treatment of visceral leishmaniasis.
Tanja Wenzler; David W Boykin; Mohamed A Ismail; James Edwin Hall; Richard R Tidwell; Reto Brun
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
R E Mdachi; J K Thuita; John Maina Kagira; J M Ngotho; Grace Murilla; J M Ndung'u; Richard R Tidwell; James Edwin Hall; R Brun
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration.

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All Publications

2010: Zhuo Wang; Xiaohua Zhu; Anuradha Srivastava; Qiang Liu; J Mark Sweat; Trupti Pandharkar; Chad E Stephens; Ed Riccio; Toufan Parman; Manoj Munde; Swati Mandal; Rentala Madhubala; Richard R Tidwell; W David Wilson; David W Boykin; James Edwin Hall; Dennis E Kyle; Karl A Werbovetz
Novel arylimidamides for treatment of visceral leishmaniasis.
Antimicrobial agents and chemotherapy 2010;54(6):2507-16.
2009: Tanja Wenzler; David W Boykin; Mohamed A Ismail; James Edwin Hall; Richard R Tidwell; Reto Brun
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
Antimicrobial agents and chemotherapy 2009;53(10):4185-92.
2009: R E Mdachi; J K Thuita; John Maina Kagira; J M Ngotho; Grace Murilla; J M Ndung'u; Richard R Tidwell; James Edwin Hall; R Brun
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration.
Antimicrobial agents and chemotherapy 2009;53(3):953-7.
2009: Xin Ming; Wujian Ju; Huali Wu; Richard R Tidwell; James Edwin Hall; Dhiren R Thakker
Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):424-30.
2008: Zhuo Wang; Judy Qiju Wu; Jennifer Dennison; Arlene Bridges; Stephen D Hall; Sally Kornbluth; Richard R Tidwell; Philip C Smith; Robert D Voyksner; Mary F Paine; James Edwin Hall
A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes.
Proteomics 2008;8(20):4186-96.
2008: David W. Wilson; Farial A Tanious; Amanda Mathis; Denise Tevis; James Edwin Hall; David W Boykin
Antiparasitic compounds that target DNA.
Biochimie 2008;90(7):999-1014.
2008: Alexa C Rosypal; Karl A Werbovetz; Manar Salem; Chad E Stephens; Arvind Kumar; David W Boykin; James Edwin Hall; Richard R Tidwell
Inhibition by Dications of in vitro growth of Leishmania major and Leishmania tropica: causative agents of old world cutaneous leishmaniasis.
The Journal of parasitology 2008;94(3):743-9.
2008: Syed M Rahmathullah; Richard R Tidwell; Susan K Jones; James Edwin Hall; David W Boykin
Carbamate prodrugs of N-alkylfuramidines.
European journal of medicinal chemistry 2008;43(1):174-7.
2007: Svetlana M Bakunova; Stanislav A Bakunov; Tanja Wenzler; Todd Barszcz; Karl A Werbovetz; Reto Brun; James Edwin Hall; Richard R Tidwell
Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations.
Journal of medicinal chemistry 2007;50(23):5807-23.
2007: Zhuo Wang; Judy Qiju Wu; Arlene Bridges; Darryl C Zeldin; Sally Kornbluth; Richard R Tidwell; James Edwin Hall; Mary F Paine
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(11):2067-75.
2007: Amanda M Mathis; Arlene Bridges; Mohamed A Ismail; Arvind Kumar; Iris Francesconi; Mariappan Anbazhagan; Qiyue Hu; Farial A Tanious; Tanja Wenzler; Janelle Y Saulter; David W. Wilson; Reto Brun; David W Boykin; Richard R Tidwell; James Edwin Hall
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
Antimicrobial agents and chemotherapy 2007;51(8):2801-10.
2007: Donald A Patrick; Stanislav A Bakunov; Svetlana M Bakunova; E V K Suresh Kumar; Richard J Lombardy; Susan Kilgore Jones; Arlene Bridges; Oksana Zhirnov; James Edwin Hall; Tanja Wenzler; Reto Brun; Richard R Tidwell
Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
Journal of medicinal chemistry 2007;50(10):2468-85.
2007: Alexa C Rosypal; James Edwin Hall; Svetlana Bakunova; Donald A Patrick; Stanislav Bakunov; Chad E Stephens; Arvind Kumar; David W Boykin; Richard R Tidwell
In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum.
Veterinary parasitology 2007;145(3-4):207-16.
2006: Zhuo Wang; Janelle Y Saulter; Etsuko Usuki; Yen-Ling Cheung; Michael Hall; Arlene Bridges; Greg Loewen; Oliver T Parkinson; Chad E Stephens; James L Allen; Darryl C Zeldin; David W Boykin; Richard R Tidwell; Andrew Parkinson; Mary F Paine; James Edwin Hall
CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
Drug metabolism and disposition: the biological fate of chemicals 2006;34(12):1985-94.
2006: Mohamed A Ismail; Reem K Arafa; Reto Brun; Tanja Wenzler; Yi Miao; David W. Wilson; Claudia Generaux; Arlene Bridges; James Edwin Hall; David W Boykin
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
Journal of medicinal chemistry 2006;49(17):5324-32.
2006: Amanda M Mathis; Jacqueline L Holman; Lisa M Sturk; Mohamed A Ismail; David W Boykin; Richard R Tidwell; James Edwin Hall
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes.
Antimicrobial agents and chemotherapy 2006;50(6):2185-91.
2005: Janelle Y Saulter; Joseph R Kurian; Lauren A Trepanier; Richard R Tidwell; Arlene Bridges; David W Boykin; Chad E Stephens; Mariappan Anbazhagan; James Edwin Hall
Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1886-93.
2005: David W. Wilson; Binh Nguyen; Farial A Tanious; Amanda Mathis; James Edwin Hall; Chad E Stephens; David W Boykin
Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):389-408.
2005: John H Ansede; Robert D Voyksner; Mohamed A Ismail; David W Boykin; Richard R Tidwell; James Edwin Hall
In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(3):211-26.
2004: John H Ansede; Mariappan Anbazhagan; Reto Brun; Judy D Easterbrook; James Edwin Hall; David W Boykin
O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
Journal of medicinal chemistry 2004;47(17):4335-8.
2004: Lisa M Sturk; Jacqueline L Brock; Charles Bagnell; James Edwin Hall; Richard R Tidwell
Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
Acta tropica 2004;91(2):131-43.
2004: Lian Zhou; Dhiren R Thakker; Robert D Voyksner; Mariappan Anbazhagan; David W Boykin; James Edwin Hall; Richard R Tidwell
Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(4):351-60.
2002: Liao Zhou; Kiho Lee; Dhiren R Thakker; David W Boykin; Richard R Tidwell; James Edwin Hall
Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug.
Pharmaceutical research 2002;19(11):1689-95.
2002: Lian Zhou; Robert D Voyksner; Dhiren R Thakker; Chad E Stephens; Mariappan Anbazhagan; David W Boykin; James Edwin Hall; Richard R Tidwell
Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry.
Rapid communications in mass spectrometry : RCM 2002;16(11):1078-85.
2000: Arlene S Pereira; Kathryn B Kenney; Myron S Cohen; James Edwin Hall; Joseph J Eron; Richard R Tidwell; John A Dunn
Simultaneous determination of lamivudine and zidovudine concentrations in human seminal plasma using high-performance liquid chromatography and tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2000;742(1):173-83.
1999: Arlene S Pereira; Angela D M Kashuba; Susan A Fiscus; James Edwin Hall; Richard R Tidwell; L Troiani; John A Dunn; Joseph J Eron; Myron S Cohen
Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.
The Journal of infectious diseases 1999;180(6):2039-43.
1999: S M Rahmathullah; James Edwin Hall; BC Bender; DR McCurdy; Richard R Tidwell; David W Boykin
Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan.
Journal of medicinal chemistry 1999;42(19):3994-4000.
1999: Donald A Patrick; James Edwin Hall; BC Bender; DR McCurdy; David W. Wilson; Farial A Tanious; S Saha; Richard R Tidwell
Synthesis and anti-Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs.
European journal of medicinal chemistry 1999;34(7-8):575-83.
1999: D H Wood; James Edwin Hall; B G Rose; D W Boykin; Richard R Tidwell
Pentamidine is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 receptors.
Annals of the New York Academy of Sciences 1999;881():110-3.
1999: I Francesconi; David W. Wilson; Farial A Tanious; James Edwin Hall; BC Bender; Richard R Tidwell; DR McCurdy; David W Boykin
2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents.
Journal of medicinal chemistry 1999;42(12):2260-5.
1998: K T Hopkins; David W. Wilson; BC Bender; DR McCurdy; James Edwin Hall; Richard R Tidwell; Arvind Kumar; Miroslav Bajic; David W Boykin
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
Journal of medicinal chemistry 1998;41(20):3872-8.
1998: D H Wood; James Edwin Hall; B G Rose; Richard R Tidwell
1,5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 binding sites.
European journal of pharmacology 1998;353(1):97-103.
1998: A el Sawalhy; John Seed; James Edwin Hall; H El Attar
Increased excretion of aromatic amino acid catabolites in animals infected with Trypanosoma brucei evansi.
The Journal of parasitology 1998;84(3):469-73.
1998: James Edwin Hall; J E Kerrigan; K Ramachandran; BC Bender; JP Stanko; Susan Kilgore Jones; Donald A Patrick; Richard R Tidwell
Anti-Pneumocystis activities of aromatic diamidoxime prodrugs.
Antimicrobial agents and chemotherapy 1998;42(3):666-74.
1998: David W Boykin; Arvind Kumar; G Xiao; David W. Wilson; BC Bender; DR McCurdy; James Edwin Hall; Richard R Tidwell
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
Journal of medicinal chemistry 1998;41(1):124-9.
1997: R H Tuttle; James Edwin Hall; Richard R Tidwell
High-performance liquid chromatographic assay detects pentamidine metabolism by Fisher rat liver microsomes.
Journal of chromatography. B, Biomedical sciences and applications 1997;688(2):319-24.
1996: J O Trent; George R Clark; A Kumar; David W. Wilson; David W Boykin; James Edwin Hall; Richard R Tidwell; B L Blagburn; Stephen Neidle
Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.
Journal of medicinal chemistry 1996;39(23):4554-62.
1995: A el Sawalhy; John Seed; H el Attar; James Edwin Hall
Catabolism of tryptophan by Trypanosoma evansi.
The Journal of eukaryotic microbiology 1995;42(6):684-90.
1995: Ulf Bronner; Orjan Ericsson; J Nordin; I Wikström; Y A Abdi; James Edwin Hall; Richard R Tidwell; Lars ´Gustafsson
Metabolism is an important route of pentamidine elimination in the rat: disposition of 14C-pentamidine and identification of metabolites in urine using liquid chromatography-tandem mass spectrometry.
Pharmacology & toxicology 1995;77(2):114-20.
1995: David W Boykin; Arvind Kumar; J Spychala; M Zhou; R J Lombardy; David W. Wilson; Christine C Dykstra; S K Jones; James Edwin Hall; Richard R Tidwell
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
Journal of medicinal chemistry 1995;38(6):912-6.
1993: Richard R Tidwell; S K Jones; N A Naiman; L C Berger; W B Brake; Christine C Dykstra; James Edwin Hall
Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia.
Antimicrobial agents and chemotherapy 1993;37(8):1713-6.
1993: H E Jones; G K Blundell; Richard R Tidwell; James Edwin Hall; S J Farr; R J Richards
The accumulation of pentamidine and the toxic effects of the drug, its selected analogues and metabolites on isolated alveolar cells.
Toxicology 1993;80(1):1-12.
1992: B J Berger; N A Naiman; James Edwin Hall; James O Peggins; Thomas G Brewer; Richard R Tidwell
Primary and secondary metabolism of pentamidine by rats.
Antimicrobial agents and chemotherapy 1992;36(9):1825-31.
1992: S Leelayoova; D Marbury; P M Rainey; N E Mackenzie; James Edwin Hall
In vitro tryptophan catabolism by Leishmania donovani donovani promastigotes.
The Journal of protozoology 1992;39(2):350-8.
1992: B J Berger; L Henry; James Edwin Hall; Richard R Tidwell
Problems and pitfalls in the assay of pentamidine. Implications for clinical use.
Clinical pharmacokinetics 1992;22(3):163-8.
1991: Richard R Tidwell; S K Jones; Christine C Dykstra; L Gorton; James Edwin Hall
Treatment of experimental Pneumocystis carinii pneumonia with 1,3-di(4-imidazolino-2-methoxyphenoxy)propane lactate.
The Journal of protozoology 1991;38(6):148S-150S.
1991: David S Lindsay; Byron L Blagburn; James Edwin Hall; Richard R Tidwell
Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures.
Antimicrobial agents and chemotherapy 1991;35(9):1914-6.
1991: Byron L Blagburn; Christine A Sundermann; David S Lindsay; James Edwin Hall; Richard R Tidwell
Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.
Antimicrobial agents and chemotherapy 1991;35(7):1520-3.
1991: C A Bell; M Cory; T A Fairley; James Edwin Hall; Richard R Tidwell
Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity.
Antimicrobial agents and chemotherapy 1991;35(6):1099-107.
1991: B J Berger; V V Reddy; S T Le; R J Lombardy; James Edwin Hall; Richard R Tidwell
Hydroxylation of pentamidine by rat liver microsomes.
The Journal of pharmacology and experimental therapeutics 1991;256(3):883-9.
1990: B J Berger; R J Lombardy; G D Marbury; C A Bell; Christine C Dykstra; James Edwin Hall; Richard R Tidwell
Metabolic N-hydroxylation of pentamidine in vitro.
Antimicrobial agents and chemotherapy 1990;34(9):1678-84.
1990: C A Bell; James Edwin Hall; Dennis E Kyle; Max Grogl; K A Ohemeng; M A Allen; Richard R Tidwell
Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.
Antimicrobial agents and chemotherapy 1990;34(7):1381-6.
1990: S K Jones; James Edwin Hall; M A Allen; S D Morrison; K A Ohemeng; V V Reddy; J D Geratz; Richard R Tidwell
Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia.
Antimicrobial agents and chemotherapy 1990;34(6):1026-30.
1990: Richard R Tidwell; S K Jones; J D Geratz; K A Ohemeng; M Cory; James Edwin Hall
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.
Journal of medicinal chemistry 1990;33(4):1252-7.
1990: B J Berger; James Edwin Hall; Richard R Tidwell
The distribution of multiple doses of pentamidine in rats.
Pharmacology & toxicology 1990;66(3):234-6.
1990: Richard R Tidwell; S K Jones; J D Geratz; K A Ohemeng; C A Bell; B J Berger; James Edwin Hall
Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia.
Annals of the New York Academy of Sciences 1990;616():421-41.
1989: B J Berger; James Edwin Hall; Richard R Tidwell
High-performance liquid chromatographic method for the quantification of several diamidine compounds with potential chemotherapeutic value.
Journal of chromatography 1989;494():191-200.
1989: Richard R Tidwell; S G Kilgore; K A Ohemeng; J D Geratz; James Edwin Hall
Treatment of experimental Pneumocystis carinii pneumonia with analogs of pentamidine.
The Journal of protozoology 1989;36(1):74S-76S.
1988: James Edwin Hall; N E Mackenzie; J M Mansfield; D E McCloskey; A I Scott
13C-NMR analysis of alanine metabolism by isolated perfused livers from C3HeB/FeJ mice infected with African trypanosomes.
Comparative biochemistry and physiology. B, Comparative biochemistry 1988;89(4):679-85.
1987: John Seed; J Sechelski; James Edwin Hall
Further biochemical characterization of chronic Trypanosoma brucei gambiense-Microtus montanus infection.
The American journal of tropical medicine and hygiene 1987;37(2):314-9.
1985: James Edwin Hall; John Seed; J B Sechelski
Multiple alpha-keto aciduria in Microtus montanus chronically infected with Trypanosoma brucei gambiense.
Comparative biochemistry and physiology. B, Comparative biochemistry 1985;82(1):73-8.
1984: James Edwin Hall; John Seed
Increased urinary excretion of aromatic amino acid catabolites by Microtus montanus chronically infected with Trypanosoma brucei gambiense.
Comparative biochemistry and physiology. B, Comparative biochemistry 1984;77(4):755-60.
1983: N E Mackenzie; James Edwin Hall; I W Flynn; A I Scott
13C nuclear magnetic resonance studies of anaerobic glycolysis in Trypanosoma brucei spp.
Bioscience reports 1983;3(2):141-51.
1983: John Seed; James Edwin Hall; C C Price
A physiological mechanism to explain pathogenesis in African trypanosomiasis.
Contributions to microbiology and immunology 1983;7():83-94.
1982: H G Shertzer; James Edwin Hall; John Seed
Hepatic microsomal alterations during chronic trypanosomiasis in the field vole, Microtus montanus.
Molecular and biochemical parasitology 1982;6(1):25-32.
1982: John Seed; James Edwin Hall; J Sechelski
Phenylalanine metabolism in Microtus montanus chronically infected with Trypanosoma brucei gambiense.
Comparative biochemistry and physiology. B, Comparative biochemistry 1982;71(2):209-15.
1981: H G Shertzer; James Edwin Hall; John Seed
Hepatic mixed-function oxidase activity in mice infected with Trypanosoma brucei gambiense or treated with trypanocides.
Molecular and biochemical parasitology 1981;3(4):199-204.
1980: John Seed; James Edwin Hall
A review on the use of Microtus montanus as an applicable experimental model for the study of African trypanosomiasis.
Annales de la Société belge de médecine tropicale 1980;60(4):341-8.
1978: I Tizard; K H Nielsen; John Seed; James Edwin Hall
Biologically active products from African Trypanosomes.
Microbiological reviews 1978;42(4):664-81.