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Michael Hall

Research Profile

Living Beings

Saccharomyces cerevisiae

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

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Publications

TOP 3
Aaron M Robitaille; Uwe Sauer; Mitsugu Shimobayashi; Paul Jenoe; Suzette Moes; Cristina Prescianotto-Baschong; Stefan Christen; Marion Cornu; Luca L Fava; Michael N Hall
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.
Mitsugu Shimobayashi; Paul Jenö; Suzette Moes; Wolfgang Oppliger; Michael N Hall
TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis.
Marion Cornu; Verena Albert; Michael N Hall
mTOR in aging, metabolism, and cancer.

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All Publications

2013: Aaron M Robitaille; Uwe Sauer; Mitsugu Shimobayashi; Paul Jenoe; Suzette Moes; Cristina Prescianotto-Baschong; Stefan Christen; Marion Cornu; Luca L Fava; Michael N Hall
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.
Science (New York, N.Y.) 2013;339(6125):1320-3.
2013: Mitsugu Shimobayashi; Paul Jenö; Suzette Moes; Wolfgang Oppliger; Michael N Hall
TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis.
Molecular biology of the cell 2013;24(6):870-81.
2013: Marion Cornu; Verena Albert; Michael N Hall
mTOR in aging, metabolism, and cancer.
Current opinion in genetics & development 2013;23(1):53-62.
2013: C Florian Bentzinger; Perrine Castets; Maitea Guridi; Michael N Hall; Christoph Handschin; Shuo Lin; Klaas Romanino; Serge Summermmatter; Lionel A Tintignac; Markus A Rüegg
Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.
Skeletal muscle 2013;3(1):6.
2012: Raúl V Durán; Michael N Hall
Glutaminolysis feeds mTORC1.
Cell cycle (Georgetown, Tex.) 2012;11(22):4107-8.
2012: Raúl V Durán; Eyal Gottlieb; Lisa Heiserich; Wolfgang Oppliger; Aaron M Robitaille; Roswitha Skendaj; Michael N Hall
Glutaminolysis activates Rag-mTORC1 signaling.
Molecular cell 2012;47(3):349-58.
2012: Raúl V Durán; Michael N Hall
Leucyl-tRNA synthetase: double duty in amino acid sensing.
Cell research 2012;22(8):1207-9.
2012: Asami Hagiwara; Charles Betz; Marion Cornu; Nadine Cybulski; Markus H Heim; Pazit Polak; Markus A Rüegg; Luigi Terracciano; Francesca Trapani; Michael N Hall
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Cell metabolism 2012;15(5):725-38.
2012: Christian Appenzeller-Herzog; Michael N Hall
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling.
Trends in cell biology 2012;22(5):274-82.
2012: Raúl V Durán; Michael N Hall
Regulation of TOR by small GTPases.
EMBO reports 2012;13(2):121-8.
2012: Aaron M Robitaille; Michael N Hall
Ramping up mitosis: an AMPKα2-regulated signaling network promotes mitotic progression.
Molecular cell 2012;45(1):8-9.
2012: Nadine Cybulski; Vittoria Zinzalla; Michael N Hall
Inducible raptor and rictor knockout mouse embryonic fibroblasts.
Methods in molecular biology (Clifton, N.J.) 2012;821():267-78.
2011: Michael N Hall
Growth grows up: COCB themed issue on cell division, growth, and death.
Current opinion in cell biology 2011;23(6):705-6.
2011: Eva Dazert; Michael N Hall
mTOR signaling in disease.
Current opinion in cell biology 2011;23(6):744-55.
2011: Don Benjamin; Marco Colombi; Christoph Moroni; Michael N Hall
Rapamycin passes the torch: a new generation of mTOR inhibitors.
Nature reviews. Drug discovery 2011;10(11):868-80.
2011: Marco Colombi; Klaus D Molle; D Benjamin; K Rattenbacher-Kiser; C Schaefer; C Betz; A Thiemeyer; U Regenass; Michael N Hall; Christoph Moroni
Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.
Oncogene 2011;30(13):1551-65.
2011: Vittoria Zinzalla; Daniele Stracka; Wolfgang Oppliger; Michael N Hall
Activation of mTORC2 by association with the ribosome.
Cell 2011;144(5):757-68.
2010: Alexandre Soulard; Alessio Cremonesi; Suzette Moes; Frédéric Schütz; Paul Jenö; Michael N Hall
The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.
Molecular biology of the cell 2010;21(19):3475-86.
2009: Nadine Cybulski; Michael N Hall
TOR complex 2: a signaling pathway of its own.
Trends in biochemical sciences 2009;34(12):620-7.
2009: Alexandre Soulard; Adiel Cohen; Michael N Hall
TOR signaling in invertebrates.
Current opinion in cell biology 2009;21(6):825-36.
2009: Nadine Cybulski; Pazit Polak; Johan Auwerx; Markus A Rüegg; Michael N Hall
mTOR complex 2 in adipose tissue negatively controls whole-body growth.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9902-7.
2009: Pazit Polak; Michael N Hall
mTOR and the control of whole body metabolism.
Current opinion in cell biology 2009;21(2):209-18.
2009: Adiel Cohen; Michael N Hall
An amino acid shuffle activates mTORC1.
Cell 2009;136(3):399-400.
2009: Ilona Patursky-Polischuk; Miri Stolovich-Rain; Mirit Hausner-Hanochi; Judith Kasir; Nadine Cybulski; Joseph Avruch; Markus A Rüegg; Michael N Hall; Oded Meyuhas
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
Molecular and cellular biology 2009;29(3):640-9.
2008: Michael N Hall
mTOR-what does it do?
Transplantation proceedings 2008;40(10 Suppl):S5-8.
2008: Stefan Gander; Debora Bonenfant; Patrick Altermatt; Dietmar E Martin; Simon Hauri; Suzette Moes; Michael N Hall; Paul Jenoe
Identification of the rapamycin-sensitive phosphorylation sites within the Ser/Thr-rich domain of the yeast Npr1 protein kinase.
Rapid communications in mass spectrometry : RCM 2008;22(23):3743-53.
2008: C Florian Bentzinger; Klaas Romanino; Dimitri Cloëtta; Shuo Lin; Joseph B Mascarenhas; Filippo Oliveri; Jinyu Xia; Emilio Casanova; Céline F Costa; Marijke Brink; Francesco Zorzato; Michael N Hall; Markus A Rüegg
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.
Cell metabolism 2008;8(5):411-24.
2008: Pazit Polak; Nadine Cybulski; Jerome N Feige; Johan Auwerx; Markus A Rüegg; Michael N Hall
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.
Cell metabolism 2008;8(5):399-410.
2007: Jörg Urban; Alexandre Soulard; Alexandre Huber; Soyeon Lippman; Debdyuti Mukhopadhyay; Olivier Deloche; Valeria Wanke; Dorothea Anrather; Gustav Ammerer; Howard Riezman; James R Broach; Claudio de Virgilio; Michael N Hall; Robbie Loewith
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Molecular cell 2007;26(5):663-74.
2007: Alexandre Soulard; Michael N Hall
SnapShot: mTOR signaling.
Cell 2007;129(2):434.
2007: Weimin Li; Marco Petrimpol; Klaus D Molle; Michael N Hall; Edouard J Battegay; Rok Humar
Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.
Circulation research 2007;100(1):79-87.
2007: Kathrin Thedieck; Pazit Polak; Man Lyang Kim; Klaus D Molle; Adiel Cohen; Paul Jenö; Cecile Arrieumerlou; Michael N Hall
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.
PloS one 2007;2(11):e1217.
2006: Jose M Mulet; Dietmar E Martin; Robbie Loewith; Michael N Hall
Mutual antagonism of target of rapamycin and calcineurin signaling.
The Journal of biological chemistry 2006;281(44):33000-7.
2006: Dietmar E Martin; Edmund (Ted) Powers; Michael N Hall
Regulation of ribosome biogenesis: where is TOR?
Cell metabolism 2006;4(4):259-60.
2006: Pazit Polak; Michael N Hall
mTORC2 Caught in a SINful Akt.
Developmental cell 2006;11(4):433-4.
2006: Yoshimi Honma; Aiko Kitamura; Ryo Shioda; Hironori Maruyama; Kanako Ozaki; Yoko Oda; Thierry Mini; Paul Jenö; Yasushi Maki; Kazuyoshi Yonezawa; Ed Hurt; Masaru Ueno; Masahiro Uritani; Michael N Hall; Takashi Ushimaru
TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.
The EMBO journal 2006;25(16):3832-42.
2006: Patricia R Wahl; Andreas L Serra; Michel Le Hir; Klaus D Molle; Michael N Hall; Rudolf P Wüthrich
Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(3):598-604.
2006: Stephan Wullschleger; Robbie Loewith; Michael N Hall
TOR signaling in growth and metabolism.
Cell 2006;124(3):471-84.
2005: Stephan Wullschleger; Robbie Loewith; Wolfgang Oppliger; Michael N Hall
Molecular organization of target of rapamycin complex 2.
The Journal of biological chemistry 2005;280(35):30697-704.
2005: Yoshiaki Kamada; Yuko Fujioka; Nobuo N Suzuki; Fuyuhiko Inagaki; Stephan Wullschleger; Robbie Loewith; Michael N Hall; Yoshinori Ohsumi
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
Molecular and cellular biology 2005;25(16):7239-48.
2005: Sonja A Dames; José M Mulet; Klara Rathgeb-Szabo; Michael N Hall; Stephan Grzesiek
The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability.
The Journal of biological chemistry 2005;280(21):20558-64.
2005: Dietmar E Martin; Michael N Hall
The expanding TOR signaling network.
Current opinion in cell biology 2005;17(2):158-66.
2004: Dietmar E Martin; Alexandre Soulard; Michael N Hall
TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.
Cell 2004;119(7):969-79.
2004: Estela Jacinto; Robbie Loewith; Anja Schmidt; Shuo Lin; Markus A Rüegg; Alan Hall; Michael N Hall
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Nature cell biology 2004;6(11):1122-8.
2004: Dietmar E Martin; Philippe Demougin; Michael N Hall; Michel Bellis
Rank Difference Analysis of Microarrays (RDAM), a novel approach to statistical analysis of microarray expression profiling data.
BMC bioinformatics 2004;5():148.
2004: Anjon Audhya; Robbie Loewith; Ainslie B Parsons; Lu Gao; Mitsuaki Tabuchi; Huilin Zhou; Charles Boone; Michael N Hall; Scott D Emr
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.
The EMBO journal 2004;23(19):3747-57.
2004: Helena Morales-Johansson; Paul Jenoe; Frank T Cooke; Michael N Hall
Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4.
The Journal of biological chemistry 2004;279(38):39604-10.
2004: José L Crespo; Stephen Helliwell; Christa Wiederkehr; Philippe Demougin; Brian Fowler; Michael Primig; Michael N Hall
NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae.
The Journal of biological chemistry 2004;279(36):37512-7.
2004: Tobias Schmelzle; Thomas Beck; Dietmar E Martin; Michael N Hall
Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast.
Molecular and cellular biology 2004;24(1):338-51.
2004: Anja Lorberg; Michael N Hall
TOR: the first 10 years.
Current topics in microbiology and immunology 2004;279():1-18.
2003: Debora Bonenfant; Tobias Schmelzle; Estela Jacinto; José L Crespo; Thierry Mini; Michael N Hall; Paul Jenoe
Quantitation of changes in protein phosphorylation: a simple method based on stable isotope labeling and mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):880-5.
2003: Estela Jacinto; Michael N Hall
Tor signalling in bugs, brain and brawn.
Nature reviews. Molecular cell biology 2003;4(2):117-26.
2002: José L Crespo; Michael N Hall
Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.
Microbiology and molecular biology reviews : MMBR 2002;66(4):579-91, table of contents.
2002: Sylvane Desrivieres; Frank T Cooke; Helena Morales-Johansson; Peter J Parker; Michael N Hall
Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae.
The Biochemical journal 2002;366(Pt 3):945-51.
2002: Robbie Loewith; Estela Jacinto; Stephan Wullschleger; Anja Lorberg; José L Crespo; Débora Bonenfant; Wolfgang Oppliger; Paul Jenoe; Michael N Hall
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Molecular cell 2002;10(3):457-68.
2002: Anja Schmidt; Tobias Schmelzle; Michael N Hall
The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae.
Molecular microbiology 2002;45(5):1433-41.
2002: José L Crespo; Edmund (Ted) Powers; Brian Fowler; Michael N Hall
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6784-9.
2002: Tobias Schmelzle; Stephen Helliwell; Michael N Hall
Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast.
Molecular and cellular biology 2002;22(5):1329-39.
2001: Sylvie Friant; R Lombardi; Tobias Schmelzle; Michael N Hall; Howard Riezman
Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast.
The EMBO journal 2001;20(23):6783-92.
2001: Estela Jacinto; B Guo; K T Arndt; Tobias Schmelzle; Michael N Hall
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Molecular cell 2001;8(5):1017-26.
2001: José L Crespo; Katsue Daicho; Takashi Ushimaru; Michael N Hall
The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in Saccharomyces cerevisiae.
The Journal of biological chemistry 2001;276(37):34441-4.
2001: T Beck; PA Delley; Michael N Hall
Control of the actin cytoskeleton by extracellular signals.
Results and problems in cell differentiation 2001;32():231-62.
2000: J Kunz; U Schneider; I Howald; Anja Schmidt; Michael N Hall
HEAT repeats mediate plasma membrane localization of Tor2p in yeast.
The Journal of biological chemistry 2000;275(47):37011-20.
2000: Tobias Schmelzle; Michael N Hall
TOR, a central controller of cell growth.
Cell 2000;103(2):253-62.
2000: G P Cosentino; Tobias Schmelzle; A Haghighat; Stephen Helliwell; Michael N Hall; Nahum Sonenberg
Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.
Molecular and cellular biology 2000;20(13):4604-13.
2000: Arndt Brachat; N Liebundguth; C Rebischung; S Lemire; F Schärer; Dominic Hoepfner; V Demchyshyn; I Howald; A Düsterhöft; D Möstl; Rainer Pöhlmann; Peter Kötter; Michael N Hall; Achim Wach; Peter Philippsen
Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames.
Yeast (Chichester, England) 2000;16(3):241-53.
1999: Masaki Inagaki; Tobias Schmelzle; K Yamaguchi; Kenji Irie; Michael N Hall; Kunihiro Matsumoto
PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.
Molecular and cellular biology 1999;19(12):8344-52.
1999: PA Delley; Michael N Hall
Cell wall stress depolarizes cell growth via hyperactivation of RHO1.
The Journal of cell biology 1999;147(1):163-74.
1999: Thomas Beck; Anja Schmidt; Michael N Hall
Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast.
The Journal of cell biology 1999;146(6):1227-38.
1999: P Danaie; Michael Altmann; Michael N Hall; Hans Trachsel; Stephen Helliwell
CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E.
The Biochemical journal 1999;340 ( Pt 1)():135-41.
1998: Anja Schmidt; Thomas Beck; A Koller; J Kunz; Michael N Hall
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.
The EMBO journal 1998;17(23):6924-31.
1998: Stephen Helliwell; Anja Schmidt; Y Ohya; Michael N Hall
The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton.
Current biology : CB 1998;8(22):1211-4.
1998: Frank T Cooke; Stephen K Dove; Robert K McEwen; GF Painter; Andrew B Holmes; Michael N Hall; Robert H Michell; Peter J Parker
The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae.
Current biology : CB 1998;8(22):1219-22.
1998: Sylvane Desrivieres; Frank T Cooke; P J Parker; Michael N Hall
MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae.
The Journal of biological chemistry 1998;273(25):15787-93.
1998: M Bickle; PA Delley; Anja Schmidt; Michael N Hall
Cell wall integrity modulates RHO1 activity via the exchange factor ROM2.
The EMBO journal 1998;17(8):2235-45.
1998: Stephen Helliwell; I Howald; N Barbet; Michael N Hall
TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.
Genetics 1998;148(1):99-112.
1997: Anja Schmidt; M Bickle; Thomas Beck; Michael N Hall
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.
Cell 1997;88(4):531-42.
1996: Anja Schmidt; J Kunz; Michael N Hall
TOR2 is required for organization of the actin cytoskeleton in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13780-5.
1996: A Koller; Joseph Heitman; Michael N Hall
Regional bivalent-univalent pairing versus trivalent pairing of a trisomic chromosome in Saccharomyces cerevisiae.
Genetics 1996;144(3):957-66.
1996: Michael N Hall
The TOR signalling pathway and growth control in yeast.
Biochemical Society transactions 1996;24(1):234-9.
1996: N C Barbet; U Schneider; Stephen Helliwell; I Stansfield; M F Tuite; Michael N Hall
TOR controls translation initiation and early G1 progression in yeast.
Molecular biology of the cell 1996;7(1):25-42.
1994: Anja Schmidt; Michael N Hall; A Koller
Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.
Molecular and cellular biology 1994;14(10):6597-606.
1994: J F Garcia-Bustos; F Marini; I Stevenson; C Frei; Michael N Hall
PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.
The EMBO journal 1994;13(10):2352-61.
1994: Stephen Helliwell; P Wagner; J Kunz; M Deuter-Reinhard; R Henriquez; Michael N Hall
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.
Molecular biology of the cell 1994;5(1):105-18.
1993: J Kunz; Michael N Hall
Cyclosporin A, FK506 and rapamycin: more than just immunosuppression.
Trends in biochemical sciences 1993;18(9):334-8.
1993: Joseph Heitman; A Koller; J Kunz; R Henriquez; Anja Schmidt; N R Movva; Michael N Hall
The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.
Molecular and cellular biology 1993;13(8):5010-9.
1993: J Kunz; R Henriquez; U Schneider; M Deuter-Reinhard; N R Movva; Michael N Hall
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.
Cell 1993;73(3):585-96.
1992: Joseph Heitman; N R Movva; Michael N Hall
Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression.
The New biologist 1992;4(5):448-60.
1991: J F Garcia-Bustos; P Wagner; Michael N Hall
Nuclear import substrates compete for a limited number of binding sites. Evidence for different classes of yeast nuclear import receptors.
The Journal of biological chemistry 1991;266(33):22303-6.
1991: Joseph Heitman; N R Movva; Michael N Hall
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
Science (New York, N.Y.) 1991;253(5022):905-9.
1991: Joseph Heitman; N R Movva; P C Hiestand; Michael N Hall
FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1948-52.
1991: J F Garcia-Bustos; P Wagner; Michael N Hall
Yeast cell-free nuclear protein import requires ATP hydrolysis.
Experimental cell research 1991;192(1):213-9.
1990: Michael N Hall; C Craik; Y Hiraoka
Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):6954-8.