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Maria Halmekytö

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Chemicals & Drugs

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Molecular Sequence Data

Physiology

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Polymerase Chain Reaction

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Publications

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Jingdong Shan; Katja Porvari; Anne Kivinen; Lila Patrikainen; Maria Halmekytö; Juhani Jänne; Pirkko Vihko
Tissue-specific expression of the prostatic acid phosphatase promoter constructs.
Kirsi Niiranen; Marko Pietilä; Tuula Pirttilä; Aki Järvinen; Maria Halmekytö; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues.
Kristina Iljin; Marika J Karkkainen; Elizabeth Lawrence; Mark A Kimak; Marko Uutela; Jussi Taipale; Katri Pajusola; L Alhonen; Maria Halmekytö; David N Finegold; Robert E Ferrell; Kari Alitalo
VEGFR3 gene structure, regulatory region, and sequence polymorphisms.

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All Publications

2003: Jingdong Shan; Katja Porvari; Anne Kivinen; Lila Patrikainen; Maria Halmekytö; Juhani Jänne; Pirkko Vihko
Tissue-specific expression of the prostatic acid phosphatase promoter constructs.
Biochemical and biophysical research communications 2003;311(4):864-9.
2002: Kirsi Niiranen; Marko Pietilä; Tuula Pirttilä; Aki Järvinen; Maria Halmekytö; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues.
The Journal of biological chemistry 2002;277(28):25323-8.
2001: Kristina Iljin; Marika J Karkkainen; Elizabeth Lawrence; Mark A Kimak; Marko Uutela; Jussi Taipale; Katri Pajusola; L Alhonen; Maria Halmekytö; David N Finegold; Robert E Ferrell; Kari Alitalo
VEGFR3 gene structure, regulatory region, and sequence polymorphisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1028-36.
2001: Veli-Pekka Korhonen; Kirsi Niiranen; Maria Halmekytö; Marko Pietilä; Paula Diegelman; Jyrki Parkkinen; T Eloranta; Carl W Porter; Leena Alhonen; Juhani Jänne
Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs.
Molecular pharmacology 2001;59(2):231-8.
1999: Sami Heikkinen; Marko Pietilä; Maria Halmekytö; Suvikki Suppola; Eija Pirinen; Samir S Deeb; Juhani Jänne; Markku Laakso
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
The Journal of biological chemistry 1999;274(32):22517-23.
1999: Leena Alhonen; Marko Pietilä; Maria Halmekytö; Debora L Kramer; Juhani Jänne; Carl W Porter
Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine.
Molecular pharmacology 1999;55(4):693-8.
1999: Suvikki Suppola; Marko Pietilä; Jyrki Parkkinen; Veli-Pekka Korhonen; Leena Alhonen; Maria Halmekytö; Carl W Porter; Juhani Jänne
Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue.
The Biochemical journal 1999;338 ( Pt 2)():311-6.
1998: Raimo Pussinen; Jouni Sirviö; Leena Alhonen; John Larson; Maria Halmekytö; Esa H Koivisto; Juhani Jänne
Preserved induction of long-term potentiation in the stratum radiatum in the CA1 field of hippocampal slices from transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine.
Synapse (New York, N.Y.) 1998;28(4):288-93.
1998: Leena Alhonen; Anne Karppinen; Mikko Uusi-Oukari; Slavoljub Vujcic; Veli-Pekka Korhonen; Maria Halmekytö; Debora L Kramer; R Hines; Juhani Jänne; Carl W Porter
Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1998;273(4):1964-9.
1997: Marko Pietilä; Leena Alhonen; Maria Halmekytö; P Kanter; Juhani Jänne; Carl W Porter
Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1997;272(30):18746-51.
1997: Ritva Heljasvaara; I Veress; Maria Halmekytö; Leena Alhonen; Juhani Jänne; P Laajala; Antti Pajunen
Transgenic mice overexpressing ornithine and S-adenosylmethionine decarboxylases maintain a physiological polyamine homoeostasis in their tissues.
The Biochemical journal 1997;323 ( Pt 2)():457-62.
1996: Mati Reeben; J Arbatova; J Palgi; Riitta Miettinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; PJ Riekkinen; Mart Saarma
Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine.
Journal of neuroscience research 1996;45(5):542-8.
1996: Leena Alhonen; Sami Heikkinen; Riitta Sinervirta; Maria Halmekytö; P Alakuijala; Juhani Jänne
Transgenic mice expressing the human ornithine decarboxylase gene under the control of mouse metallothionein I promoter.
The Biochemical journal 1996;314 ( Pt 2)():405-8.
1995: Leena Alhonen; Maria Halmekytö; Veli-Matti Kosma; Jarmo Wahlfors; Risto A Kauppinen; Juhani Jänne
Life-long over-expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration.
International journal of cancer. Journal international du cancer 1995;63(3):402-4.
1995: Veli-Pekka Korhonen; Maria Halmekytö; L Kauppinen; S Myöhänen; Jarmo Wahlfors; T Keinänen; T Hyvönen; Leena Alhonen; T Eloranta; Juhani Jänne
Molecular cloning of a cDNA encoding human spermine synthase.
DNA and cell biology 1995;14(10):841-7.
1995: J Korhonen; I Lahtinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; Daniel J Dumont; Kari Alitalo
Endothelial-specific gene expression directed by the tie gene promoter in vivo.
Blood 1995;86(5):1828-35.
1994: Juhani Jänne; Juha Hyttinen; T Peura; M Tolvanen; Leena Alhonen; Riitta Sinervirta; Maria Halmekytö
Transgenic bioreactors.
The International journal of biochemistry 1994;26(7):859-70.
1994: Juha Hyttinen; T Peura; M Tolvanen; J Aalto; Leena Alhonen; Riitta Sinervirta; Maria Halmekytö; S Myöhänen; Juhani Jänne
Generation of transgenic dairy cattle from transgene-analyzed and sexed embryos produced in vitro.
Bio/technology (Nature Publishing Company) 1994;12(6):606-8.
1993: H Hakovirta; A Keiski; Jorma Toppari; Maria Halmekytö; Leena Alhonen; J Jänne; Martti Parvinen
Polyamines and regulation of spermatogenesis: selective stimulation of late spermatogonia in transgenic mice overexpressing the human ornithine decarboxylase gene.
Molecular endocrinology (Baltimore, Md.) 1993;7(11):1430-6.
1993: Toivo Halonen; Juhani Sivenius; Riitta Miettinen; Maria Halmekytö; Risto A Kauppinen; Riitta Sinervirta; L Alakuijala; Leena Alhonen; E MacDonald; Juhani Jänne
Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.
The European journal of neuroscience 1993;5(9):1233-9.
1993: L Kauppinen; S Myöhänen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Transgenic mice over-expressing the human spermidine synthase gene.
The Biochemical journal 1993;293 ( Pt 2)():513-6.
1993: Maria Halmekytö; Juha Hyttinen; Riitta Sinervirta; Pia Leppänen; Juhani Jänne; Leena Alhonen
Regulation of the expression of human ornithine decarboxylase gene and ornithine decarboxylase promoter-driven reporter gene in transgenic mice.
The Biochemical journal 1993;292 ( Pt 3)():927-32.
1993: Mati Reeben; Maria Halmekytö; Leena Alhonen; Riitta Sinervirta; Mart Saarma; Juhani Jänne
Tissue-specific expression of rat light neurofilament promoter-driven reporter gene in transgenic mice.
Biochemical and biophysical research communications 1993;192(2):465-70.
1993: Maria Halmekytö; Leena Alhonen; L Alakuijala; Juhani Jänne
Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines.
The Biochemical journal 1993;291 ( Pt 2)():505-8.
1992: Maria Halmekytö; Kari Syrjänen; Juhani Jänne; Leena Alhonen
Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene.
Biochemical and biophysical research communications 1992;187(1):493-7.
1992: Juhani Jänne; Juha Hyttinen; T Peura; M Tolvanen; Leena Alhonen; Maria Halmekytö
Transgenic animals as bioproducers of therapeutic proteins.
Annals of medicine 1992;24(4):273-80.
1992: Risto A Kauppinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Nuclear magnetic resonance spectroscopy study on energy metabolism, intracellular pH, and free Mg2+ concentration in the brain of transgenic mice overexpressing human ornithine decarboxylase gene.
Journal of neurochemistry 1992;58(3):831-6.
1991: Maria Halmekytö; Leena Alhonen; Jarmo Wahlfors; Riitta Sinervirta; Olli A Jänne; Juhani Jänne
Position-independent, aberrant expression of the human ornithine decarboxylase gene in transgenic mice.
Biochemical and biophysical research communications 1991;180(1):262-7.
1991: Maria Halmekytö; Juha Hyttinen; Riitta Sinervirta; M Utriainen; S Myöhänen; H M Voipio; Jarmo Wahlfors; S Syrjänen; Kari Syrjänen; Leena Alhonen
Transgenic mice aberrantly expressing human ornithine decarboxylase gene.
The Journal of biological chemistry 1991;266(29):19746-51.
1991: Maria Halmekytö; Leena Alhonen; Jarmo Wahlfors; Riitta Sinervirta; T Eloranta; Juhani Jänne
Characterization of a transgenic mouse line over-expressing the human ornithine decarboxylase gene.
The Biochemical journal 1991;278 ( Pt 3)():895-8.
1991: I M Hyttinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Levels of ornithine decarboxylase genomic sequences, heterogeneous nuclear RNA and mRNA in human myeloma cells resistant to alpha-difluoromethylornithine.
The Biochemical journal 1991;278 ( Pt 3)():871-4.
1990: Noreen J Hickok; Jarmo Wahlfors; A Crozat; Maria Halmekytö; Leena Alhonen; J Jänne; Olli A Jänne
Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.
Gene 1990;93(2):257-63.
1989: Maria Halmekytö; A Hirvonen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Methylation of human ornithine decarboxylase gene before transfection abolishes its transient expression in Chinese hamster ovary cells.
Biochemical and biophysical research communications 1989;162(1):528-34.