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James Halpert

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Amino Acid Sequence

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Co-Publications
Name
22
He, You Ai
16
He, You Qun
16
Szklarz, Grazyna
15
Harlow, GR
13
Davydov, Dmitri
12
Kumar, Santosh
11
Liu, Hong
11
Domanski, Tammy
10
Scott, Emily
9
Khan, Kishore
8
Muralidhara, BK
6
Sipes, Glenn
6
Wang, Qinmi
6
Sun, Ling
6
Johnson, Eric

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Publications

TOP 3
Gay Sean C; Sun Ling; Maekawa Keiko; Halpert James R; Stout C David
Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Kumar Santosh; Qiu Huan; Oezguen Numan; Herlyn Holger; Halpert James R; Wojnowski Leszek
Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.
Talakad Jyothi C; Kumar Santosh; Halpert James R
Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.

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All Publications

2009: Gay Sean C; Sun Ling; Maekawa Keiko; Halpert James R; Stout C David
Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry 2009;48(22):4762-71.
2009: Kumar Santosh; Qiu Huan; Oezguen Numan; Herlyn Holger; Halpert James R; Wojnowski Leszek
Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(6):1328-33.
2009: Talakad Jyothi C; Kumar Santosh; Halpert James R
Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):644-50.
2008: Davydov Dmitri R; Halpert James R
Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?
Expert opinion on drug metabolism & toxicology 2008;4(12):1523-35.
2008: Davydov Dmitri R; Davydova Nadezhda Y; Halpert James R
Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.
Biochemistry 2008;47(43):11348-59.
2008: Oezguen Numan; Kumar Santosh; Hindupur Aditya; Braun Werner; Muralidhara B K; Halpert James R
Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.
The Journal of biological chemistry 2008;283(31):21808-16.
2008: Muralidhara B K; Sun Ling; Negi Surendra; Halpert James R
Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors.
Journal of molecular biology 2008;377(1):232-45.
2008: Davydov Dmitri R; Davydova Nadezhda Y; Tsalkova Tamara N; Halpert James R
Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.
Archives of biochemistry and biophysics 2008;471(2):134-45.
2008: Fernando Harshica; Halpert James R; Davydov Dmitri R
Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.
Archives of biochemistry and biophysics 2008;471(1):20-31.
2007: Kumar Santosh; Zhao Yonghong; Sun Ling; Negi Surendra S; Halpert James R; Muralidhara B K
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Molecular pharmacology 2007;72(5):1191-9.
2007: Zhao Yonghong; Sun Ling; Muralidhara B K; Kumar Santosh; White Mark A; Stout C David; Halpert James R
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Biochemistry 2007;46(41):11559-67.
2007: Davydov Dmitri R; Baas Bradley J; Sligar Stephen G; Halpert James R
Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.
Biochemistry 2007;46(26):7852-64.
2007: Fernando Harshica; Davydov Dmitri R; Chin Christopher C; Halpert James R
Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.
Archives of biochemistry and biophysics 2007;460(1):129-40.
2007: Zhao Yonghong; Halpert James R
Structure-function analysis of cytochromes P450 2B.
Biochimica et biophysica acta 2007;1770(3):402-12.
2007: Muralidhara B K; Negi Surendra S; Halpert James R
Dissecting the thermodynamics and cooperativity of ligand binding in cytochrome P450eryF.
Journal of the American Chemical Society 2007;129(7):2015-24.
2007: Sun Ling; Chen Chong S; Waxman David J; Liu Hong; Halpert James R; Kumar Santosh
Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
Archives of biochemistry and biophysics 2007;458(2):167-74.
2007: Tsalkova Tamara N; Davydova Nadezhda Y; Halpert James R; Davydov Dmitri R
Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.
Biochemistry 2007;46(1):106-19.
2007: Muralidhara B K; Halpert James R
Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry.
Drug metabolism reviews 2007;39(2-3):539-56.
2006: Kumar Santosh; Sun Ling; Liu Hong; Muralidhara B K; Halpert James R
Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.
Protein engineering, design & selection : PEDS 2006;19(12):547-54.
2006: Kumar Santosh; Liu Hong; Halpert James R
Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(12):1958-65.
2006: Hernandez Cynthia E; Kumar Santosh; Liu Hong; Halpert James R
Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.
Archives of biochemistry and biophysics 2006;455(1):61-7.
2006: Davydov Dmitri R; Fernando Harshica; Halpert James R
Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450.
Biophysical chemistry 2006;123(2-3):95-101.
2006: Mast Natalia; Murtazina Dilyara; Liu Hong; Graham Sandra E; Bjorkhem Ingemar; Halpert James R; Peterson Julian; Pikuleva Irina A
Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies.
Biochemistry 2006;45(14):4396-404.
2006: Fernando Harshica; Halpert James R; Davydov Dmitri R
Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration.
Biochemistry 2006;45(13):4199-209.
2006: Muralidhara B K; Negi Surendra; Chin Christopher C; Braun Werner; Halpert James R
Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling.
The Journal of biological chemistry 2006;281(12):8051-61.
2006: Zhao Yonghong; White Mark A; Muralidhara B K; Sun Ling; Halpert James R; Stout C David
Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
The Journal of biological chemistry 2006;281(9):5973-81.
2005: Kumar Santosh; Halpert James R
Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts.
Biochemical and biophysical research communications 2005;338(1):456-64.
2005: Davydov Dmitri R; Fernando Harshica; Baas Bradley J; Sligar Stephen G; Halpert James R
Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.
Biochemistry 2005;44(42):13902-13.
2005: Kumar Santosh; Davydov Dmitri R; Halpert James R
Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1131-6.
2005: Davydov Dmitri R; Botchkareva Alexandra E; Davydova Nadezhda E; Halpert James R
Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe.
Biophysical journal 2005;89(1):418-32.
2005: Li Weihua; Liu Hong; Scott Emily E; Gräter Frauke; Halpert James R; Luo Xiaoming; Shen Jianhua; Jiang Hualiang
Possible pathway(s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):910-9.
2005: Kumar Santosh; Chen Chong S; Waxman David J; Halpert James R
Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.
The Journal of biological chemistry 2005;280(20):19569-75.
2005: Honma Wataru; Li Weihua; Liu Hong; Scott Emily E; Halpert James R
Functional role of residues in the helix B' region of cytochrome P450 2B1.
Archives of biochemistry and biophysics 2005;435(1):157-65.
2005: Gupta Ram P; He You Ai; Patrick Kennerly S; Halpert James R; Bell Norman H
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.
The Journal of clinical endocrinology and metabolism 2005;90(2):1210-9.
2005: Scott Emily E; Halpert James R
Structures of cytochrome P450 3A4.
Trends in biochemical sciences 2005;30(1):5-7.
2004: Davydov Dmitri R; Botchkareva Alexandra E; Kumar Santosh; He You Qun; Halpert James R
An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.
Biochemistry 2004;43(21):6475-85.
2004: Scott Emily E; White Mark A; He You Ai; Johnson Eric F; Stout C David; Halpert James R
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.
The Journal of biological chemistry 2004;279(26):27294-301.
2004: Chen Chong-Sheng; Lin Jack T; Goss Kendrick A; He You-ai; Halpert James R; Waxman David J
Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
Molecular pharmacology 2004;65(5):1278-85.
2004: Scott Emily E; Liu Hong; Qun He You; Li Weihua; Halpert James R
Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix.
Archives of biochemistry and biophysics 2004;423(2):266-76.
2004: Yamaguchi Yoshitaka; Khan Kishore K; He You Ai; He You Qun; Halpert James R
Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):155-61.
2003: Davydov Dmitri R; Halpert James R; Renaud Jean-Paul; Hui Bon Hoa Gaston
Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.
Biochemical and biophysical research communications 2003;312(1):121-30.
2003: Scott Emily E; He You Ai; Wester Michael R; White Mark A; Chin Christopher C; Halpert James R; Johnson Eric F; Stout C David
An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13196-201.
2003: Kumar Santosh; Scott Emily E; Liu Hong; Halpert James R
A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.
The Journal of biological chemistry 2003;278(19):17178-84.
2003: Khan Kishore K; Liu Hong; Halpert James R
Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(4):356-9.
2003: Spatzenegger Margit; Liu Hong; Wang Qinmi; Debarber Andrea; Koop Dennis R; Halpert James R
Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.
The Journal of pharmacology and experimental therapeutics 2003;304(1):477-87.
2003: He You Ai; Roussel Fabienne; Halpert James R
Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling.
Archives of biochemistry and biophysics 2003;409(1):92-101.
2002: Scott Emily E; He You Qun; Halpert James R
Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.
Chemical research in toxicology 2002;15(11):1407-13.
2002: Khan Kishore K; He You Qun; Correia Maria Almira; Halpert James R
Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(9):985-90.
2002: Khan Kishore K; He You Ai; He You Qun; Halpert James R
Site-directed mutagenesis of cytochrome P450eryF: implications for substrate oxidation, cooperativity, and topology of the active site.
Chemical research in toxicology 2002;15(6):843-53.
2002: Khan Kishore K; Halpert James R
7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe.
Chemical research in toxicology 2002;15(6):806-14.
2002: Davydov Dmitri R; Kumar Santosh; Halpert James R
Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate.
Biochemical and biophysical research communications 2002;294(4):806-12.
2002: Khan Kishore K; He You Qun; Domanski Tammy L; Halpert James R
Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation.
Molecular pharmacology 2002;61(3):495-506.
2002: Wang Qinmi; Halpert James R
Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P450 2B6 substrates and protein homology modeling.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(1):86-95.
2001: Scott E E; Spatzenegger M; Halpert J R
A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function.
Archives of biochemistry and biophysics 2001;395(1):57-68.
2001: Domanski T L; He Y Q; Scott E E; Wang Q; Halpert J R
The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.
Archives of biochemistry and biophysics 2001;394(1):21-8.
2001: Fontaine S M; Hoyer P B; Halpert J R; Sipes I G
Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(9):1236-42.
2001: Domanski T L; He Y A; Khan K K; Roussel F; Wang Q; Halpert J R
Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.
Biochemistry 2001;40(34):10150-60.
2001: Domanski T L; Halpert J R
Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis.
Current drug metabolism 2001;2(2):117-37.
2001: Xue L; Wang H F; Wang Q; Szklarz G D; Domanski T L; Halpert J R; Correia M A
Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation.
Chemical research in toxicology 2001;14(5):483-91.
2001: He Y Q; Roussel F; Halpert J R
Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
Archives of biochemistry and biophysics 2001;389(2):264-70.
2001: Spatzenegger M; Wang Q; He Y Q; Wester M R; Johnson E F; Halpert J R
Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles.
Molecular pharmacology 2001;59(3):475-84.
2001: Domanski T L; Finta C; Halpert J R; Zaphiropoulos P G
cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.
Molecular pharmacology 2001;59(2):386-92.
2000: Domanski T L; He Y A; Harlow G R; Halpert J R
Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.
The Journal of pharmacology and experimental therapeutics 2000;293(2):585-91.
2000: Roussel F; Khan K K; Halpert J R
The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4.
Archives of biochemistry and biophysics 2000;374(2):269-78.
2000: Khan K K; Halpert J R
Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes.
Archives of biochemistry and biophysics 2000;373(2):335-45.
1999: Domanski T L; Schultz K M; Roussel F; Stevens J C; Halpert J R
Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1141-7.
1999: Waller S C; He Y A; Harlow G R; He Y Q; Mash E A; Halpert J R
2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
Chemical research in toxicology 1999;12(8):690-9.
1999: Stevens J C; Domanski T L; Harlow G R; White R B; Orton E; Halpert J R
Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis.
The Journal of pharmacology and experimental therapeutics 1999;290(2):594-602.
1999: Strobel S M; Szklarz G D; He Y; Foroozesh M; Alworth W L; Roberts E S; Hollenberg P F; Halpert J R
Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility.
The Journal of pharmacology and experimental therapeutics 1999;290(1):445-51.
1999: Doerr-Stevens J K; Liu J; Stevens G J; Kraner J C; Fontaine S M; Halpert J R; Sipes I G
Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):281-7.
1999: Fraser D J; He Y Q; Harlow G R; Halpert J R
Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26.
Molecular pharmacology 1999;55(2):241-7.
1998: Halpert J R; Domanski T L; Adali O; Biagini C P; Cosme J; Dierks E A; Johnson E F; Jones J P; Ortiz de Montellano P; Philpot R M; Sibbesen O; Wyatt W K; Zheng Z
Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(12):1223-31.
1998: Szklarz G D; Halpert J R
Molecular basis of P450 inhibition and activation: implications for drug development and drug therapy.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(12):1179-84.
1998: Kobayashi Y; Strobel S M; Hopkins N E; Alworth W L; Halpert J R
Catalytic properties of an expressed cytochrome P450 2B1 from a Wistar-Kyoto rat liver cDNA library.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(10):1026-30.
1998: Wang H; Dick R; Yin H; Licad-Coles E; Kroetz D L; Szklarz G; Harlow G; Halpert J R; Correia M A
Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.
Biochemistry 1998;37(36):12536-45.
1998: Harlow G R; Halpert J R
Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6636-41.
1998: Kobayashi Y; Fang X; Szklarz G D; Halpert J R
Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants.
Biochemistry 1998;37(19):6679-88.
1998: He Y Q; Harlow G R; Szklarz G D; Halpert J R
Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
Archives of biochemistry and biophysics 1998;350(2):333-9.
1998: Domanski T L; Liu J; Harlow G R; Halpert J R
Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.
Archives of biochemistry and biophysics 1998;350(2):223-32.
1998: Badger D; Kraner J; Fraser D; Hoglen N; Halpert J; Sipes I G
Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol.
Life sciences 1998;63(25):PL367-72.
1997: Fraser D J; Feyereisen R; Harlow G R; Halpert J R
Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1425-32.
1997: Roberts E S; Hopkins N E; Foroozesh M; Alworth W L; Halpert J R; Hollenberg P F
Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1242-8.
1997: Fang X; Kobayashi Y; Halpert J R
Stoichiometry of 7-ethoxycoumarin metabolism by cytochrome P450 2B1 wild-type and five active-site mutants.
FEBS letters 1997;416(1):77-80.
1997: Kent U M; Hanna I H; Szklarz G D; Vaz A D; Halpert J R; Bend J R; Hollenberg P F
Significance of glycine 478 in the metabolism of N-benzyl-1-aminobenzotriazole to reactive intermediates by cytochrome P450 2B1.
Biochemistry 1997;36(39):11707-16.
1997: Strobel S M; Halpert J R
Reassessment of cytochrome P450 2B2: catalytic specificity and identification of four active site residues.
Biochemistry 1997;36(39):11697-706.
1997: He Y A; He Y Q; Szklarz G D; Halpert J R
Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
Biochemistry 1997;36(29):8831-9.
1997: Szklarz G D; Halpert J R
Molecular modeling of cytochrome P450 3A4.
Journal of computer-aided molecular design 1997;11(3):265-72.
1997: Harlow G R; He Y A; Halpert J R
Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.
Biochimica et biophysica acta 1997;1338(2):259-66.
1997: Harlow G R; Halpert J R
Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity.
The Journal of biological chemistry 1997;272(9):5396-402.
1997: Szklarz G D; Halpert J R
Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450.
Life sciences 1997;61(26):2507-20.
1996: Fang X; Halpert J R
Dithionite-supported hydroxylation of palmitic acid by cytochrome P450BM-3.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(11):1282-5.
1996: He Y Q; Szklarz G D; Halpert J R
Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
Archives of biochemistry and biophysics 1996;335(1):152-60.
1996: He K; He Y A; Szklarz G D; Halpert J R; Correia M A
Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation.
The Journal of biological chemistry 1996;271(42):25864-72.
1996: Born S L; Fraser D J; Harlow G R; Halpert J R
Escherichia coli expression and substrate specificities of canine cytochrome P450 3A12 and rabbit cytochrome P450 3A6.
The Journal of pharmacology and experimental therapeutics 1996;278(2):957-63.
1996: Szklarz G D; He Y Q; Kedzie K M; Halpert J R; Burnett V L
Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
Archives of biochemistry and biophysics 1996;327(2):308-18.
1996: Liu J; He Y A; Halpert J R
Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
Archives of biochemistry and biophysics 1996;327(1):167-73.
1996: Harlow G R; Halpert J R
Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.
Archives of biochemistry and biophysics 1996;326(1):85-92.
1996: Poet T S; McQueen C A; Halpert J R
Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(1):74-80.
1996: Kraner J C; Morgan E T; Poet T S; Born S L; Burnett V L; Halpert J R
Suppression of rat hepatic microsomal cytochromes P450 by cyclophosphamide is correlated with plasma thyroid hormone levels and displays differential strain sensitivity.
The Journal of pharmacology and experimental therapeutics 1996;276(1):258-64.
1995: Klekotka P A; Halpert J R
Benzyloxyresorufin as a specific substrate for the major phenobarbital-inducible dog liver cytochrome P450 (P4502B11).
Drug metabolism and disposition: the biological fate of chemicals 1995;23(12):1434-5.
1995: Szklarz G D; He Y A; Halpert J R
Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1.
Biochemistry 1995;34(44):14312-22.
1995: Klekotka P A; Richardson T H; Johnson E F; Halpert J R
Inactivation of Escherichia coli-expressed rabbit cytochrome P-450 2C enzymes by 17 beta-substituted steroids.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1450-5.
1995: Born S L; John G H; Harlow G R; Halpert J R
Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(7):702-7.
1995: He Y Q; He Y A; Halpert J R
Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
Chemical research in toxicology 1995;8(4):574-9.
1995: Grimm S W; Bend J R; Halpert J R
Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(5):577-83.
1994: Grimm S W; Dyroff M C; Philpot R M; Halpert J R
Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism.
Molecular pharmacology 1994;46(6):1090-9.
1994: John G H; Hasler J A; He Y A; Halpert J R
Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.
Archives of biochemistry and biophysics 1994;314(2):367-75.
1994: Kraner J C; Morgan E T; Halpert J R
Selective suppression of rat hepatic cytochrome P450 2C11 by chloramphenicol.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1367-72.
1994: Hasler J A; Harlow G R; Szklarz G D; John G H; Kedzie K M; Burnett V L; He Y A; Kaminsky L S; Halpert J R
Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
Molecular pharmacology 1994;46(2):338-45.
1994: Szklarz G D; Ornstein R L; Halpert J R
Application of 3-dimensional homology modeling of cytochrome P450 2B1 for interpretation of site-directed mutagenesis results.
Journal of biomolecular structure & dynamics 1994;12(1):061-78.
1994: Poet T S; Brendel K; Halpert J R
Inactivation of cytochromes P450 2B protects against cocaine-mediated toxicity in rat liver slices.
Toxicology and applied pharmacology 1994;126(1):26-32.
1994: Halpert J R; Guengerich F P; Bend J R; Correia M A
Selective inhibitors of cytochromes P450.
Toxicology and applied pharmacology 1994;125(2):163-75.
1994: He Y; Luo Z; Klekotka P A; Burnett V L; Halpert J R
Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites.
Biochemistry 1994;33(14):4419-24.
1994: Luo Z; He Y A; Halpert J R
Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
Archives of biochemistry and biophysics 1994;309(1):52-7.
1993: Ryan R; Grimm S W; Kedzie K M; Halpert J R; Philpot R M
Cloning, sequencing, and functional studies of phenobarbital-inducible forms of cytochrome P450 2B and 4B expressed in rabbit kidney.
Archives of biochemistry and biophysics 1993;304(2):454-63.
1993: Kedzie K M; Grimm S W; Chen F; Halpert J R
Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11.
Biochimica et biophysica acta 1993;1164(2):124-32.
1993: Halpert J R; He Y A
Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
The Journal of biological chemistry 1993;268(6):4453-7.
1992: He Y A; Balfour C A; Kedzie K M; Halpert J R
Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1.
Biochemistry 1992;31(38):9220-6.
1992: Swanson B A; Halpert J R; Bornheim L M; Ortiz de Montellano P R
Topological analysis of the active sites of cytochromes P450IIB4 (rabbit), P450IIB10 (mouse), and P450IIB11 (dog) by in situ rearrangement of phenyl-iron complexes.
Archives of biochemistry and biophysics 1992;292(1):42-6.
1991: Kedzie K M; Philpot R M; Halpert J R
Functional expression of mammalian cytochromes P450IIB in the yeast Saccharomyces cerevisiae.
Archives of biochemistry and biophysics 1991;291(1):176-86.
1991: Kedzie K M; Balfour C A; Escobar G Y; Grimm S W; He Y A; Pepperl D J; Regan J W; Stevens J C; Halpert J R
Molecular basis for a functionally unique cytochrome P450IIB1 variant.
The Journal of biological chemistry 1991;266(33):22515-21.
1991: Ciaccio P J; Graves P E; Bourque D P; Glinsmann-Gibson B; Halpert J R
cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.
Biochimica et biophysica acta 1991;1088(2):319-22.
1990: Smith B J; Sipes I G; Stevens J C; Halpert J R
The biochemical basis for the species difference in hepatic microsomal 4-vinylcyclohexene epoxidation between female mice and rats.
Carcinogenesis 1990;11(11):1951-7.
1990: Graves P E; Elhag G A; Ciaccio P J; Bourque D P; Halpert J R
cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
Archives of biochemistry and biophysics 1990;281(1):106-15.
1989: Ciaccio P J; Halpert J R
Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily.
Archives of biochemistry and biophysics 1989;271(2):284-99.
1989: Halpert J R; Jaw J Y; Johnson E F
Design of specific mechanism-based inactivators of hepatic and adrenal microsomal cytochromes P-450 responsible for progesterone 21-hydroxylation.
Drug metabolism reviews 1989;20(2-4):645-55.
1988: Duignan D B; Sipes I G; Ciaccio P J; Halpert J R
The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2.
Archives of biochemistry and biophysics 1988;267(1):294-304.
1988: Halpert J R
Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes.
Archives of biochemistry and biophysics 1988;263(1):59-68.
1987: Ciaccio P J; Duignan D B; Halpert J R
Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P-450.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(6):852-6.
1987: Miller N E; Halpert J R
Mechanism-based inactivation of the major beta-naphthoflavone-inducible isozyme of rat liver cytochrome P-450 by the chloramphenicol analog N-(2-p-nitrophenethyl)dichloroacetamide.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(6):846-51.
1987: Duignan D B; Sipes I G; Leonard T B; Halpert J R
Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
Archives of biochemistry and biophysics 1987;255(2):290-303.

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