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Robert Haltiwanger

Research Profile

Chemicals & Drugs

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Glycosylation

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Publications

TOP 3
Esam Al-Shareffi; Jean-Luc Chaubard; Christina Leonhard-Melief; Sheng-Kai Wang; Chi-Huey Wong; Robert S Haltiwanger
6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.
Shinya Yamamoto; Ke Zhang; Vafa Bayat; Wu-Lin Charng; Gabriela David; Robert S Haltiwanger; Manish Jaiswal; Shinako Kakuda; Nadia A Rana; Hector Sandoval; Hao Wang; Bo Xiong; Hugo J Bellen
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.
Hideyuki Takeuchi; Thomas K Weldeghiorghis; Devin S Caswell; Rodrigo C Fernández-Valdivia; Thomas P Garner; Hamed Jafar-Nejad; Megan A Macnaughtan; Aleksandra Nita-Lazar; Nadia A Rana; Robert S Haltiwanger
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.

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All Publications

2013: Esam Al-Shareffi; Jean-Luc Chaubard; Christina Leonhard-Melief; Sheng-Kai Wang; Chi-Huey Wong; Robert S Haltiwanger
6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.
Glycobiology 2013;23(2):188-98.
2012: Shinya Yamamoto; Ke Zhang; Vafa Bayat; Wu-Lin Charng; Gabriela David; Robert S Haltiwanger; Manish Jaiswal; Shinako Kakuda; Nadia A Rana; Hector Sandoval; Hao Wang; Bo Xiong; Hugo J Bellen
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.
Science (New York, N.Y.) 2012;338(6111):1229-32.
2011: Hideyuki Takeuchi; Thomas K Weldeghiorghis; Devin S Caswell; Rodrigo C Fernández-Valdivia; Thomas P Garner; Hamed Jafar-Nejad; Megan A Macnaughtan; Aleksandra Nita-Lazar; Nadia A Rana; Robert S Haltiwanger
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16600-5.
2011: Robert S Haltiwanger; Ten Feizi
Glycobiology: the study of the sweet life.
Current opinion in structural biology 2011;21(5):573-5.
2011: Nadia A Rana; Robert S Haltiwanger
Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors.
Current opinion in structural biology 2011;21(5):583-9.
2011: Nadia A Rana; Hideyuki Takeuchi; Shinako Kakuda; Kelvin B Luther; Aleksandra Nita-Lazar; Robert S Haltiwanger
O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.
The Journal of biological chemistry 2011;286(36):31623-37.
2011: Rodrigo Fernandez-Valdivia; Hideyuki Takeuchi; Amin Samarghandi; Mario Lopez; Jessica Leonardi; Robert S Haltiwanger; Hamed Jafar-Nejad
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.
Development (Cambridge, England) 2011;138(10):1925-34.
2010: Jianguang Du; Hideyuki Takeuchi; Christina Leonhard-Melief; Kenneth R Shroyer; Malgosia Dlugosz; Robert S Haltiwanger; Bernadette C Holdener
O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
Developmental biology 2010;346(1):25-38.
2010: Hideyuki Takeuchi; Robert S Haltiwanger
Role of glycosylation of Notch in development.
Seminars in cell & developmental biology 2010;21(6):638-45.
2009: Robert S Haltiwanger
Fucose is on the TRAIL of colon cancer.
Gastroenterology 2009;137(1):36-9.
2009: Kelvin B Luther; Robert S Haltiwanger
Role of unusual O-glycans in intercellular signaling.
The international journal of biochemistry & cell biology 2009;41(5):1011-24.
2009: Kelvin B Luther; Hermann Schindelin; Robert S Haltiwanger
Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants.
The Journal of biological chemistry 2009;284(5):3294-305.
2008: Hiroyuki O Ishikawa; Hideyuki Takeuchi; Robert S Haltiwanger; Kenneth D Irvine
Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains.
Science (New York, N.Y.) 2008;321(5887):401-4.
2008: Robert S Haltiwanger
Unsweetened Notch leads to myeloproliferation.
Blood 2008;112(2):214-5.
2008: Melih Acar; Hamed Jafar-Nejad; Hideyuki Takeuchi; Akhila Rajan; Dafina Ibrani; Nadia A Rana; Hongling Pan; Robert S Haltiwanger; Hugo J Bellen
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.
Cell 2008;132(2):247-58.
2007: Aiguo Xu; Nicola Haines; Malgosia Dlugosz; Nadia A Rana; Hideyuki Takeuchi; Robert S Haltiwanger; Kenneth D Irvine
In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe.
The Journal of biological chemistry 2007;282(48):35153-62.
2007: Shaolin Shi; Changhui Ge; Yi Luo; Xinghua Hou; Robert S Haltiwanger; Pamela Stanley
The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling.
The Journal of biological chemistry 2007;282(28):20133-41.
2007: Lindsay M Ricketts; Malgosia Dlugosz; Kelvin B Luther; Robert S Haltiwanger; Elaine M Majerus
O-fucosylation is required for ADAMTS13 secretion.
The Journal of biological chemistry 2007;282(23):17014-23.
2007: Lauren W Wang; Malgosia Dlugosz; Robert Somerville; Mona Raed; Robert S Haltiwanger; Suneel S Apte
O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily.
The Journal of biological chemistry 2007;282(23):17024-31.
2007: Raajit Rampal; Kelvin B Luther; Robert S Haltiwanger
Notch signaling in normal and disease States: possible therapies related to glycosylation.
Current molecular medicine 2007;7(4):427-45.
2006: Krisztina Kozma; Jeremy J Keusch; Björn Hegemann; Kelvin B Luther; Dominique Klein; daniel Hess; Robert S Haltiwanger; Jan Hofsteenge
Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats.
The Journal of biological chemistry 2006;281(48):36742-51.
2006: C Loriol; Fabrice Dupuy; Raajit Rampal; Malgosia Dlugosz; Robert S Haltiwanger; Abderrahman Maftah; Agnès Germot
Molecular evolution of protein O-fucosyltransferase genes and splice variants.
Glycobiology 2006;16(8):736-47.
2006: Yi Luo; Aleksandra Nita-Lazar; Robert S Haltiwanger
Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats.
The Journal of biological chemistry 2006;281(14):9385-92.
2006: Yi Luo; Kate Koles; Wendy Vorndam; Robert S Haltiwanger; Vladislav M Panin
Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats.
The Journal of biological chemistry 2006;281(14):9393-9.
2006: Aleksandra Nita-Lazar; Robert S Haltiwanger
Methods for analysis of O-linked modifications on epidermal growth factor-like and thrombospondin type 1 repeats.
Methods in enzymology 2006;417():93-111.
2006: Aleksandra Nita-Lazar; Robert S Haltiwanger
Methods for analysis of unusual forms of O-glycosylation.
Methods in molecular biology (Clifton, N.J.) 2006;347():57-68.
2005: Raajit Rampal; Annie S Y Li; Daniel J Moloney; Stephanie A Georgiou; Kelvin B Luther; Aleksandra Nita-Lazar; Robert S Haltiwanger
Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.
The Journal of biological chemistry 2005;280(51):42454-63.
2005: Raajit Rampal; Joseph F Arboleda-Velasquez; Aleksandra Nita-Lazar; Kenneth S Kosik; Robert S Haltiwanger
Highly conserved O-fucose sites have distinct effects on Notch1 function.
The Journal of biological chemistry 2005;280(37):32133-40.
2005: Joseph F Arboleda-Velasquez; Raajit Rampal; Erik Fung; Diane C Darland; Min Liu; Maria C Martinez; Christine P Donahue; Manuel F Navarro-Gonzalez; Peter Libby; Patricia A D'Amore; Masanori Aikawa; Robert S Haltiwanger; Kenneth S Kosik
CADASIL mutations impair Notch3 glycosylation by Fringe.
Human molecular genetics 2005;14(12):1631-9.
2005: Yi Luo; Robert S Haltiwanger
O-fucosylation of notch occurs in the endoplasmic reticulum.
The Journal of biological chemistry 2005;280(12):11289-94.
2005: Guangtao Li; Qi Yan; Aleksandra Nita-Lazar; Robert S Haltiwanger; William J Lennarz
Studies on the N-glycosylation of the subunits of oligosaccharyl transferase in Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(3):1864-71.
2004: Robert S Haltiwanger; John B Lowe
Role of glycosylation in development.
Annual review of biochemistry 2004;73():491-537.
2003: Sarah Hatsell; Lillian Medina; Joe Merola; Robert S Haltiwanger; Pamela Cowin
Plakoglobin is O-glycosylated close to the N-terminal destruction box.
The Journal of biological chemistry 2003;278(39):37745-52.
2003: Laura Sturla; Raajit Rampal; Robert S Haltiwanger; Floriana Fruscione; Amos Etzioni; Michela Tonetti
Differential terminal fucosylation of N-linked glycans versus protein O-fucosylation in leukocyte adhesion deficiency type II (CDG IIc).
The Journal of biological chemistry 2003;278(29):26727-33.
2003: Li Shao; Daniel J Moloney; Robert S Haltiwanger
Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region.
The Journal of biological chemistry 2003;278(10):7775-82.
2003: Li Shao; Robert S Haltiwanger
O-fucose modifications of epidermal growth factor-like repeats and thrombospondin type 1 repeats: unusual modifications in unusual places.
Cellular and molecular life sciences : CMLS 2003;60(2):241-50.
2002: Robert S Haltiwanger; Pamela Stanley
Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.
Biochimica et biophysica acta 2002;1573(3):328-35.
2002: Li Shao; Yi Luo; Daniel J Moloney; Robert S Haltiwanger
O-glycosylation of EGF repeats: identification and initial characterization of a UDP-glucose: protein O-glucosyltransferase.
Glycobiology 2002;12(11):763-70.
2002: Robert S Haltiwanger
Regulation of signal transduction pathways in development by glycosylation.
Current opinion in structural biology 2002;12(5):593-8.
2002: Vladislav M Panin; Li Shao; Liang Lei; Daniel J Moloney; Kenneth D Irvine; Robert S Haltiwanger
Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe.
The Journal of biological chemistry 2002;277(33):29945-52.
2002: Yu-Ting Yan; Jan-Jan Liu; Yi Luo; Chaosu E; Robert S Haltiwanger; Cory Abate-Shen; Michael M Shen
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.
Molecular and cellular biology 2002;22(13):4439-49.
2000: Daniel J Moloney; Vladislav M Panin; SH Johnston; J Chen; Li Shao; R Wilson; Y Wang; Pamela Stanley; Kenneth D Irvine; Robert S Haltiwanger; Thomas F Vogt
Fringe is a glycosyltransferase that modifies Notch.
Nature 2000;406(6794):369-75.
2000: Daniel J Moloney; L H Shair; F M Lu; J Xia; Robert D Locke; K L Matta; Robert S Haltiwanger
Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules.
The Journal of biological chemistry 2000;275(13):9604-11.
1999: Daniel J Moloney; Robert S Haltiwanger
The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-beta1,3-glucosyltransferase activity from Chinese hamster ovary cells.
Glycobiology 1999;9(7):679-87.
1998: L Medina; K Grove; Robert S Haltiwanger
SV40 large T antigen is modified with O-linked N-acetylglucosamine but not with other forms of glycosylation.
Glycobiology 1998;8(4):383-91.
1998: Robert S Haltiwanger; K Grove; GA Philipsberg
Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate.
The Journal of biological chemistry 1998;273(6):3611-7.
1998: L Medina; Robert S Haltiwanger
Calf thymus high mobility group proteins are nonenzymatically glycated but not significantly glycosylated.
Glycobiology 1998;8(2):191-8.
1997: Daniel J Moloney; A I Lin; Robert S Haltiwanger
The O-linked fucose glycosylation pathway. Evidence for protein-specific elongation of o-linked fucose in Chinese hamster ovary cells.
The Journal of biological chemistry 1997;272(30):19046-50.
1997: Robert S Haltiwanger; GA Philipsberg
Mitotic arrest with nocodazole induces selective changes in the level of O-linked N-acetylglucosamine and accumulation of incompletely processed N-glycans on proteins from HT29 cells.
The Journal of biological chemistry 1997;272(13):8752-8.
1997: Robert S Haltiwanger; S Busby; K Grove; S Li; D Mason; L Medina; Daniel J Moloney; GA Philipsberg; R Scartozzi
O-glycosylation of nuclear and cytoplasmic proteins: regulation analogous to phosphorylation?
Biochemical and biophysical research communications 1997;231(2):237-42.
1994: A I Lin; G A Philipsberg; Robert S Haltiwanger
Core fucosylation of high-mannose-type oligosaccharides in GlcNAc transferase I-deficient (Lec1) CHO cells.
Glycobiology 1994;4(6):895-901.