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Shigeyuki Hamada

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Dan Takeuchi; Nithita Wongwan; Amara Yowang; Sininat Petcharat; Anupong Pienpringam; Sutit Samerchea; Pathom Sawanpanyalert; Yukihiro Akeda; Prasanee Areeratana; Phanupong Chaiwongsaen; Piphat Chiranairadul; Surang Dejsirilert; Shigeyuki Hamada; Anusak Kerdsin; Kasean Khamisara; Suwat Lertchayanti; Phacharaphan Loetthong; Pakkinee Luangsuk; Tatsuya Nakayama; Kazunori Oishi
Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand.
Masanobu Nakata; Eiji Oiki; Nobuo Okahashi; Andreas Podbielski; Akinari Sugauchi; Tomoko Sumitomo; Yutaka Terao; Satoshi Wada; Shigeyuki Hamada; Miharu Higashino; Ryutaro Isoda; Keiji Richard Kimura; Bernd Kreikemeyer; Shigetada Kawabata
Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes.
Masaya Yamaguchi; Yuki Minamide; Yutaka Terao; Ryutaro Isoda; Taiji Ogawa; Shin-ichi Yokota; Shigeyuki Hamada; Shigetada Kawabata
Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis.

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All Publications

2012: Dan Takeuchi; Nithita Wongwan; Amara Yowang; Sininat Petcharat; Anupong Pienpringam; Sutit Samerchea; Pathom Sawanpanyalert; Yukihiro Akeda; Prasanee Areeratana; Phanupong Chaiwongsaen; Piphat Chiranairadul; Surang Dejsirilert; Shigeyuki Hamada; Anusak Kerdsin; Kasean Khamisara; Suwat Lertchayanti; Phacharaphan Loetthong; Pakkinee Luangsuk; Tatsuya Nakayama; Kazunori Oishi
Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand.
PloS one 2012;7(2):e31265.
2011: Masanobu Nakata; Eiji Oiki; Nobuo Okahashi; Andreas Podbielski; Akinari Sugauchi; Tomoko Sumitomo; Yutaka Terao; Satoshi Wada; Shigeyuki Hamada; Miharu Higashino; Ryutaro Isoda; Keiji Richard Kimura; Bernd Kreikemeyer; Shigetada Kawabata
Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes.
The Journal of biological chemistry 2011;286(43):37566-77.
2009: Masaya Yamaguchi; Yuki Minamide; Yutaka Terao; Ryutaro Isoda; Taiji Ogawa; Shin-ichi Yokota; Shigeyuki Hamada; Shigetada Kawabata
Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis.
Biochemical and biophysical research communications 2009;390(1):155-60.
2009: Yutaka Terao; R Isoda; J Murakami; Shigeyuki Hamada; Shigetada Kawabata
Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans.
Oral microbiology and immunology 2009;24(3):211-7.
2008: Eiji Kunitomo; Yutaka Terao; Shigefumi Okamoto; Tetsuya Rikimaru; Shigeyuki Hamada; Shigetada Kawabata
Molecular and biological characterization of histidine triad protein in group A streptococci.
Microbes and infection / Institut Pasteur 2008;10(4):414-23.
2008: Yutaka Terao; Yuka Mori; Masaya Yamaguchi; Yoshikata Shimizu; Kenji Ooe; Shigeyuki Hamada; Shigetada Kawabata
Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity.
The Journal of biological chemistry 2008;283(10):6253-60.
2008: J Lapirattanakul; Kazuhiko Nakano; Ryota Nomura; Shigeyuki Hamada; Ichiro Nakagawa; Takashi Ooshima
Demonstration of mother-to-child transmission of Streptococcus mutans using multilocus sequence typing.
Caries research 2008;42(6):466-74.
2007: S Okamoto; Y Terao; H Kaminishi; Shigeyuki Hamada; Shigetada Kawabata
Inflammatory immune responses by water-insoluble alpha-glucans.
Journal of dental research 2007;86(3):242-8.
2006: Masaya Yamaguchi; Yutaka Terao; Taiji Ogawa; Toshihito Takahashi; Shigeyuki Hamada; Shigetada Kawabata
Role of Streptococcus sanguinis sortase A in bacterial colonization.
Microbes and infection / Institut Pasteur 2006;8(12-13):2791-6.
2006: Yutaka Terao; Masaya Yamaguchi; Shigeyuki Hamada; Shigetada Kawabata
Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils.
The Journal of biological chemistry 2006;281(20):14215-23.
2006: Akane Takemura; Ichiro Nakagawa; Shinji Kawai; Hiroaki Inaba; Takahiro Kato; Shigeyuki Hamada; Atsuo Amano
Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells.
Journal of periodontology 2006;77(5):883-90.
2005: Yutaka Terao; Shigefumi Okamoto; Kosuke Kataoka; Shigeyuki Hamada; Shigetada Kawabata
Protective immunity against Streptococcus pyogenes challenge in mice after immunization with fibronectin-binding protein.
The Journal of infectious diseases 2005;192(12):2081-91.
2005: Shigefumi Okamoto; Yasuharu Tamura; Yutaka Terao; Shigeyuki Hamada; Shigetada Kawabata
Systemic immunization with streptococcal immunoglobulin-binding protein Sib 35 induces protective immunity against group: a Streptococcus challenge in mice.
Vaccine 2005;23(40):4852-9.
2005: Kazuhiko Nakano; Ryota Nomura; Ichiro Nakagawa; Shigeyuki Hamada; Takashi Ooshima
Role of glucose side chains with serotype-specific polysaccharide in the cariogenicity of Streptococcus mutans.
Caries research 2005;39(4):262-8.
2005: Ichiro Nakagawa; Atsuo Amano; Hiroaki Inaba; Shinji Kawai; Shigeyuki Hamada
Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins.
Microbes and infection / Institut Pasteur 2005;7(2):157-63.
2004: Ichiro Nakagawa; Atsuo Amano; Noboru Mizushima; Akitsugu Yamamoto; Hitomi Yamaguchi; Takahiro Kamimoto; Atsuki Nara; Junko Funao; Masanobu Nakata; Kayoko Tsuda; Shigeyuki Hamada; Tamotsu Yoshimori
Autophagy defends cells against invading group A Streptococcus.
Science (New York, N.Y.) 2004;306(5698):1037-40.
2004: Kazuhiko Nakano; Ryota Nomura; Noriko Shimizu; Ichiro Nakagawa; Shigeyuki Hamada; Takashi Ooshima
Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains.
Journal of clinical microbiology 2004;42(11):4925-30.
2004: Makoto Tamesada; Shigetada Kawabata; Taku Fujiwara; Shigeyuki Hamada
Synergistic effects of streptococcal glucosyltransferases on adhesive biofilm formation.
Journal of dental research 2004;83(11):874-9.
2004: Shigefumi Okamoto; Shigetada Kawabata; Yutaka Terao; Hideaki Fujitaka; Yoshinobu Okuno; Shigeyuki Hamada
The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection.
Infection and immunity 2004;72(10):6068-75.
2004: Ichiro Nakagawa; Masanobu Nakata; Shigetada Kawabata; Shigeyuki Hamada
Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells.
Cellular microbiology 2004;6(10):939-52.
2004: Shigefumi Okamoto; Shigetada Kawabata; Hideaki Fujitaka; Takashi Uehira; Yoshinobu Okuno; Shigeyuki Hamada
Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection.
Vaccine 2004;22(21-22):2887-93.
2004: Nobuo Okahashi; Hiroaki Inaba; Ichiro Nakagawa; Taihei Yamamura; Masae Kuboniwa; Koji Nakayama; Shigeyuki Hamada; Atsuo Amano
Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway.
Infection and immunity 2004;72(3):1706-14.
2004: Kazuhiko Nakano; Ryota Nomura; Ichiro Nakagawa; Shigeyuki Hamada; Takashi Ooshima
Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity.
Journal of clinical microbiology 2004;42(1):198-202.
2004: Hidekazu Sasaki; Michiyo Matsumoto; T Tanaka; M Maeda; M Nakai; Shigeyuki Hamada; Takashi Ooshima
Antibacterial activity of polyphenol components in oolong tea extract against Streptococcus mutans.
Caries research 2004;38(1):2-8.
2003: Michiyo Matsumoto; Shigeyuki Hamada; Takashi Ooshima
Molecular analysis of the inhibitory effects of oolong tea polyphenols on glucan-binding domain of recombinant glucosyltransferases from Streptococcus mutans MT8148.
FEMS microbiology letters 2003;228(1):73-80.
2003: Atsuo Sakurai; Nobuo Okahashi; Ichiro Nakagawa; Shigetada Kawabata; Atsuo Amano; Takashi Ooshima; Shigeyuki Hamada
Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand.
Infection and immunity 2003;71(10):6019-26.
2003: Ichiro Nakagawa; Ken Kurokawa; Atsushi Yamashita; Masanobu Nakata; Yusuke Tomiyasu; Nobuo Okahashi; Shigetada Kawabata; Kiyoshi Yamazaki; Tadayoshi Shiba; Teruo Yasunaga; Hideo Hayashi; Masahira Hattori; Shigeyuki Hamada
Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution.
Genome research 2003;13(6A):1042-55.
2003: Shigefumi Okamoto; Shigetada Kawabata; Ichiro Nakagawa; Yoshinobu Okuno; Toshiyuki Goto; Kouichi Sano; Shigeyuki Hamada
Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice.
Journal of virology 2003;77(7):4104-12.
2003: Nobuo Okahashi; Atsuo Sakurai; Ichiro Nakagawa; Taku Fujiwara; Shigetada Kawabata; Atsuo Amano; Shigeyuki Hamada
Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells.
Infection and immunity 2003;71(2):948-55.
2002: Yutaka Terao; Shigetada Kawabata; Masanobu Nakata; Ichiro Nakagawa; Shigeyuki Hamada
Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients.
The Journal of biological chemistry 2002;277(49):47428-35.
2002: Ichiro Nakagawa; Atsuo Amano; Y Ohara-Nemoto; N Endoh; Ichijiro Morisaki; Shigenobu Kimura; Shigetada Kawabata; Shigeyuki Hamada
Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis.
Journal of periodontal research 2002;37(6):425-32.
2002: Shigetada Kawabata; Yasuharu Tamura; Jumpei Murakami; Yutaka Terao; Ichiro Nakagawa; Shigeyuki Hamada
A novel, anchorless streptococcal surface protein that binds to human immunoglobulins.
Biochemical and biophysical research communications 2002;296(5):1329-33.
2002: Ichiro Nakagawa; Masanobu Nakata; Taihei Yamamura; Satoshi Wakisaka; Shigetada Kawabata; Shigeyuki Hamada
Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice.
Microbial pathogenesis 2002;33(2):63-72.
2002: J Murakami; Shigetada Kawabata; Y Terao; K Kikuchi; K Totsuka; Aki Tamaru; Chihiro Katsukawa; K Moriya; Ichiro Nakagawa; Ichijiro Morisaki; Shigeyuki Hamada
Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994-9.
Epidemiology and infection 2002;128(3):397-404.
2002: Kazuhiko Nakano; Mieko Matsumura; Mamoru Kawaguchi; Taku Fujiwara; Shizuo Sobue; Ichiro Nakagawa; Shigeyuki Hamada; Takashi Ooshima
Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: analysis of strains isolated from human blood.
Journal of dental research 2002;81(6):376-9.
2002: Taku Fujiwara; Tomonori Hoshino; Takashi Ooshima; Shigeyuki Hamada
Differential and quantitative analyses of mRNA expression of glucosyltransferases from Streptococcus mutans MT8148.
Journal of dental research 2002;81(2):109-13.
2002: Yutaka Terao; Shigetada Kawabata; Eiji Kunitomo; Ichiro Nakagawa; Shigeyuki Hamada
Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells.
Infection and immunity 2002;70(2):993-7.
2002: Ichiro Nakagawa; Atsuo Amano; Masae Kuboniwa; Takayuki Nakamura; Shigetada Kawabata; Shigeyuki Hamada
Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells.
Infection and immunity 2002;70(1):277-85.
2001: Shigefumi Okamoto; Shigetada Kawabata; Ichiro Nakagawa; Shigeyuki Hamada
Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells.
Infection and immunity 2001;69(11):6633-42.
2001: Taku Fujiwara; Kazuhiko Nakano; Mamoru Kawaguchi; Takashi Ooshima; Shizuo Sobue; Shigetada Kawabata; Ichiro Nakagawa; Shigeyuki Hamada
Biochemical and genetic characterization of serologically untypable Streptococcus mutans strains isolated from patients with bacteremia.
European journal of oral sciences 2001;109(5):330-4.
2001: Yutaka Terao; Shigetada Kawabata; Eiji Kunitomo; J Murakami; Ichiro Nakagawa; Shigeyuki Hamada
Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator.
Molecular microbiology 2001;42(1):75-86.
2001: Ichiro Nakagawa; Masanobu Nakata; Shigetada Kawabata; Shigeyuki Hamada
Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells.
Cellular microbiology 2001;3(6):395-405.
2001: Masae Kuboniwa; Atsuo Amano; Satoshi Shizukuishi; Ichiro Nakagawa; Shigeyuki Hamada
Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection.
Infection and immunity 2001;69(5):2972-9.
2001: Atsuo Amano; T Premaraj; Masae Kuboniwa; Ichiro Nakagawa; Satoshi Shizukuishi; Ichijiro Morisaki; Shigeyuki Hamada
Altered antigenicity in periodontitis patients and decreased adhesion of Porphyromonas gingivalis by environmental temperature stress.
Oral microbiology and immunology 2001;16(2):124-8.
2001: Atsuo Amano; T Kishima; S Akiyama; Ichiro Nakagawa; Shigeyuki Hamada; Ichijiro Morisaki
Relationship of periodontopathic bacteria with early-onset periodontitis in Down's syndrome.
Journal of periodontology 2001;72(3):368-73.
2001: Shigetada Kawabata; Eiji Kunitomo; Yutaka Terao; Ichiro Nakagawa; K Kikuchi; K Totsuka ; Shigeyuki Hamada
Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice.
Infection and immunity 2001;69(2):924-30.
2000: Atsuo Amano; Masae Kuboniwa; Ichiro Nakagawa; S Akiyama; Ichijiro Morisaki; Shigeyuki Hamada
Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status.
Journal of dental research 2000;79(9):1664-8.
2000: Ichiro Nakagawa; Atsuo Amano; R K Kimura; Tadashi Nakamura; Shigetada Kawabata; Shigeyuki Hamada
Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene.
Journal of clinical microbiology 2000;38(5):1909-14.
2000: Taku Fujiwara; Tomonori Hoshino; Takashi Ooshima; Shizuo Sobue; Shigeyuki Hamada
Purification, characterization, and molecular analysis of the gene encoding glucosyltransferase from Streptococcus oralis.
Infection and immunity 2000;68(5):2475-83.
2000: Shigetada Kawabata; Y Terao; Shigeyuki Hamada
Molecular cloning, sequence and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene.
Oral microbiology and immunology 2000;15(1):58-62.
2000: Atsuo Amano; T Kishima; Shigenobu Kimura; M Takiguchi; Takashi Ooshima; Shigeyuki Hamada; Ichijiro Morisaki
Periodontopathic bacteria in children with Down syndrome.
Journal of periodontology 2000;71(2):249-55.
1999: Shigetada Kawabata; Yutaka Terao; Taku Fujiwara; Ichiro Nakagawa; Shigeyuki Hamada
Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice.
Infection and immunity 1999;67(11):5863-8.
1999: Michiyo Matsumoto; T Minami; Hidekazu Sasaki; Shizuo Sobue; Shigeyuki Hamada; Takashi Ooshima
Inhibitory effects of oolong tea extract on caries-inducing properties of mutans streptococci.
Caries research 1999;33(6):441-5.
1999: Ichiro Nakagawa; M Nakata; Shigetada Kawabata; Shigeyuki Hamada
Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells.
Molecular microbiology 1999;33(6):1190-9.
1999: Masanori Kontani; Atsuo Amano; Tadashi Nakamura; Ichiro Nakagawa; Shigetada Kawabata; Shigeyuki Hamada
Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis.
Infection and immunity 1999;67(9):4917-20.
1999: Shigetada Kawabata; H Kuwata; Ichiro Nakagawa; S Morimatsu; K Sano; Shigeyuki Hamada
Capsular hyaluronic acid of group A streptococci hampers their invasion into human pharyngeal epithelial cells.
Microbial pathogenesis 1999;27(2):71-80.
1999: Kosuke Kataoka; Atsuo Amano; Shigetada Kawabata; Hideki Nagata; Shigeyuki Hamada; Satoshi Shizukuishi
Secretion of functional salivary peptide by Streptococcus gordonii which inhibits fimbria-mediated adhesion of Porphyromonas gingivalis.
Infection and immunity 1999;67(8):3780-5.
1999: Tadashi Nakamura; Atsuo Amano; Ichiro Nakagawa; Shigeyuki Hamada
Specific interactions between Porphyromonas gingivalis fimbriae and human extracellular matrix proteins.
FEMS microbiology letters 1999;175(2):267-72.
1999: Atsuo Amano; Tadashi Nakamura; Shigenobu Kimura; Ichijiro Morisaki; Ichiro Nakagawa; Shigetada Kawabata; Shigeyuki Hamada
Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: kinetic analyses based on surface plasmon resonance.
Infection and immunity 1999;67(5):2399-405.
1999: Atsuo Amano; Ichiro Nakagawa; Kosuke Kataoka; Ichijiro Morisaki; Shigeyuki Hamada
Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients.
Journal of clinical microbiology 1999;37(5):1426-30.
1999: Masahiko Yanagita; Takachika Hiroi; N Kitagaki; Shigeyuki Hamada; Hiroaki Ito; H Shimauchi; Shinya Murakami; Hiroshi Okada; Hiroshi Kiyono
Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3559-65.
1999: Shigetada Kawabata; Shigeyuki Hamada
Studying biofilm formation of mutans streptococci.
Methods in enzymology 1999;310():513-23.
1999: Atsuo Amano; Ichiro Nakagawa; Shigeyuki Hamada
Studying initial phase of biofilm formation: molecular interaction of host proteins and bacterial surface components.
Methods in enzymology 1999;310():501-13.
1998: A Takemura; N Matsuda; Shigenobu Kimura; Taku Fujiwara; Ichiro Nakagawa; Shigeyuki Hamada
Porphyromonas gingivalis lipopolysaccharide modulates the responsiveness of human periodontal ligament fibroblasts to platelet-derived growth factor.
Journal of periodontal research 1998;33(7):400-7.
1998: Shigeyuki Hamada; Atsuo Amano; Shigenobu Kimura; Ichiro Nakagawa; Shigetada Kawabata; Ichijiro Morisaki
The importance of fimbriae in the virulence and ecology of some oral bacteria.
Oral microbiology and immunology 1998;13(3):129-38.
1998: Atsuo Amano; Satoshi Shizukuishi; H Horie; Shigenobu Kimura; Ichijiro Morisaki; Shigeyuki Hamada
Binding of Porphyromonas gingivalis fimbriae to proline-rich glycoproteins in parotid saliva via a domain shared by major salivary components.
Infection and immunity 1998;66(5):2072-7.
1998: Taku Fujiwara; Y Terao; Tomonori Hoshino; Shigetada Kawabata; Takashi Ooshima; Shizuo Sobue; S Kimura; Shigeyuki Hamada
Molecular analyses of glucosyltransferase genes among strains of Streptococcus mutans.
FEMS microbiology letters 1998;161(2):331-6.
1998: Takashi Ooshima; T Minami; Michiyo Matsumoto; Taku Fujiwara; Shizuo Sobue; Shigeyuki Hamada
Comparison of the cariostatic effects between regimens to administer oolong tea polyphenols in SPF rats.
Caries research 1998;32(1):75-80.
1997: Shigetada Kawabata; Y Terao; T Andoh; Shigeyuki Hamada
Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii.
FEMS microbiology letters 1997;156(2):211-6.
1997: Masanori Kontani; Shigenobu Kimura; Ichiro Nakagawa; Shigeyuki Hamada
Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease.
Molecular microbiology 1997;24(6):1179-87.
1997: Atsuo Amano; Taku Fujiwara; Hideki Nagata; Masae Kuboniwa; A Sharma; Hakimuddin T Sojar; Robert J Genco; Shigeyuki Hamada; Satoshi Shizukuishi
Prophyromonas gingivalis fimbriae mediate coaggregation with Streptococcus oralis through specific domains.
Journal of dental research 1997;76(4):852-7.
1997: Makoto Tamesada; Shigetada Kawabata; Z Bian; Taku Fujiwara; S Kimura; Shigeyuki Hamada
Modification of sucrose dependent cell adherence by deletion and reintroduction of the gtf genes in Streptococcus mutans.
Advances in experimental medicine and biology 1997;418():665-8.
1996: I Takahashi; Ichiro Nakagawa; L Xu; Shigeyuki Hamada
Role of alpha beta T cells and gamma delta T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice by targeted gene disruption.
Journal of periodontal research 1996;31(8):589-95.
1996: Shigeyuki Hamada
[Characterization of virulence factors of mutans streptococci and specific inhibition of these factors].
Nihon saikingaku zasshi. Japanese journal of bacteriology 1996;51(4):931-51.
1996: Shigeyuki Hamada; M Kontani; H Hosono; H Ono; T Tanaka; Takashi Ooshima; T Mitsunaga; I Abe
Peroxidase-catalyzed generation of catechin oligomers that inhibit glucosyltransferase from Streptococcus sobrinus.
FEMS microbiology letters 1996;143(1):35-40.
1996: I Nakagawa; Ichiro Takahashi; Hiroshi Kiyono; J R McGhee; Shigeyuki Hamada
Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches.
The Journal of infectious diseases 1996;173(6):1428-36.
1996: T Fujiwara; M Tamesada; Z Bian; Shigetada Kawabata; Shigenobu Kimura; Shigeyuki Hamada
Deletion and reintroduction of glucosyltransferase genes of Streptococcus mutans and role of their gene products in sucrose dependent cellular adherence.
Microbial pathogenesis 1996;20(4):225-33.
1996: M Kontani; H Ono; H Shibata; Y Okamura; T Tanaka; T Fujiwara; Shigenobu Kimura; Shigeyuki Hamada
Cysteine protease of Porphyromonas gingivalis 381 enhances binding of fimbriae to cultured human fibroblasts and matrix proteins.
Infection and immunity 1996;64(3):756-62.
1995: I Takahashi; I Nakagawa; L Xu; Shigeyuki Hamada
IL-12 rescues galactosamine-loaded mice from lethal shock triggered by staphylococcal enterotoxin.
Biochemical and biophysical research communications 1995;217(1):74-80.
1995: Shigenobu Kimura; T Koga; T Fujiwara; M Kontani; K Shintoku; H Kaya; Shigeyuki Hamada
Tyrosine protein phosphorylation in murine B lymphocytes by stimulation with lipopolysaccharide from Porphyromonas gingivalis.
FEMS microbiology letters 1995;130(1):1-6.
1995: I Takahashi; I Nakagawa; H Kiyono; J R McGhee; John Clements; Shigeyuki Hamada
Mucosal T cells induce systemic anergy for oral tolerance.
Biochemical and biophysical research communications 1995;206(1):414-20.
1995: Shigeyuki Hamada; Tomohiko Ogawa; Yutaka Kusumoto
Generation and distribution of antibody secreting cells in salivary glands of mice immunized with Porphyromonas gingivalis fimbriae.
Advances in experimental medicine and biology 1995;371B():1113-7.
1994: T Fujiwara; Ichiro Nakagawa; S Morishima; I Takahashi; Shigeyuki Hamada
Inconsistency between the fimbrilin gene and the antigenicity of lipopolysaccharides in selected strains of Porphyromonas gingivalis.
FEMS microbiology letters 1994;124(3):333-41.
1994: Tomohiko Ogawa; H Ogo; Shigeyuki Hamada
Chemotaxis of human monocytes by synthetic peptides that mimic segments of Porphyromonas gingivalis fimbrial protein.
Oral microbiology and immunology 1994;9(5):257-61.
1994: Tomohiko Ogawa; Shigeyuki Hamada
Hemagglutinating and chemotactic properties of synthetic peptide segments of fimbrial protein from Porphyromonas gingivalis.
Infection and immunity 1994;62(8):3305-10.
1994: Tomohiko Ogawa; H Ogo; H Uchida; Shigeyuki Hamada
Humoral and cellular immune responses to the fimbriae of Porphyromonas gingivalis and their synthetic peptides.
Journal of medical microbiology 1994;40(6):397-402.
1994: Tomohiko Ogawa; H Uchida; Shigeyuki Hamada
Porphyromonas gingivalis fimbriae and their synthetic peptides induce proinflammatory cytokines in human peripheral blood monocyte cultures.
FEMS microbiology letters 1994;116(2):237-42.
1994: Takashi Ooshima; Toshiomi Yoshida; Shigeyuki Hamada
Detection of caries-inducing microorganisms in hyposalivated rats without infection of mutans streptococci.
Microbiology and immunology 1994;38(1):39-45.
1994: Takashi Ooshima; T Minami; W Aono; Y Tamura; Shigeyuki Hamada
Reduction of dental plaque deposition in humans by oolong tea extract.
Caries research 1994;28(3):146-9.
1994: Shigeyuki Hamada; T Fujiwara; S Morishima; I Takahashi; Ichiro Nakagawa; Shigenobu Kimura; Tomohiko Ogawa
Molecular and immunological characterization of the fimbriae of Porphyromonas gingivalis.
Microbiology and immunology 1994;38(12):921-30.
1993: T Fujiwara; S Morishima; I Takahashi; Shigeyuki Hamada
Molecular cloning and sequencing of the fimbrilin gene of Porphyromonas gingivalis strains and characterization of recombinant proteins.
Biochemical and biophysical research communications 1993;197(1):241-7.
1993: I Takahashi; N Okahashi; Shigeyuki Hamada
Molecular characterization of a negative regulator of Streptococcus sobrinus surface protein antigen gene.
Journal of bacteriology 1993;175(14):4345-53.
1993: H Takada; S Kimura; Shigeyuki Hamada
Induction of inflammatory cytokines by a soluble moiety prepared from an enzyme lysate of Actinomyces viscosus cell walls.
Journal of medical microbiology 1993;38(6):395-400.
1993: Yutaka Kusumoto; Tomohiko Ogawa; Shigeyuki Hamada
Generation of specific antibody-secreting cells in salivary glands of BALB/c mice following parenteral or oral immunization with Porphyromonas gingivalis fimbriae.
Archives of oral biology 1993;38(5):361-7.
1993: Shigetada Kawabata; Mitsuo Torii; T Minami; T Fujiwara; Shigeyuki Hamada
Effects of selected surfactants on purified glucosyltransferases from mutans streptococci and cellular adherence to smooth surfaces.
Journal of medical microbiology 1993;38(1):54-60.
1993: Takashi Ooshima; T Minami; W Aono; A Izumitani; Shizuo Sobue; T Fujiwara; Shigetada Kawabata; Shigeyuki Hamada
Oolong tea polyphenols inhibit experimental dental caries in SPF rats infected with mutans streptococci.
Caries research 1993;27(2):124-9.
1992: Tomohiko Ogawa; S Kuribayashi; H Shimauchi; T Toda; Shigeyuki Hamada
Immunochemical and biological characterization of outer membrane proteins of Porphyromonas endodontalis.
Infection and immunity 1992;60(11):4528-33.
1992: T Fujiwara; Shigetada Kawabata; Shigeyuki Hamada
Molecular characterization and expression of the cell-associated glucosyltransferase gene from Streptococcus mutans.
Biochemical and biophysical research communications 1992;187(3):1432-8.
1992: Tomohiko Ogawa; Yutaka Kusumoto; Hiroshi Kiyono; J R McGhee; Shigeyuki Hamada
Occurrence of antigen-specific B cells following oral or parenteral immunization with Porphyromonas gingivalis fimbriae.
International immunology 1992;4(9):1003-10.
1992: Ichijiro Morisaki; J P Loyola-Rodríguez; C Adachi; Shigeyuki Hamada
Effects of phenytoin on dental caries and plaque in Streptococcus sobrinus-infected rats.
Pediatric dentistry 1992;14(5):322-5.
1992: T Takei; Tomohiko Ogawa; S Alaluusua; T Fujiwara; Ichijiro Morisaki; Takashi Ooshima; Shizuo Sobue; Shigeyuki Hamada
Latex agglutination test for detection of mutans streptococci in relation to dental caries in children.
Archives of oral biology 1992;37(2):99-104.
1992: Juan Pablo Loyola-Rodriguez; Ichijiro Morisaki; K Kitamura; Shigeyuki Hamada
Purification and properties of extracellular mutacin, a bacteriocin from Streptococcus sobrinus.
Journal of general microbiology 1992;138(2):269-74.
1992: Takashi Ooshima; A Izumitani; T Minami; Toshiomi Yoshida; Shizuo Sobue; T Fujiwara; Shigeyuki Hamada
Noncariogenicity of maltitol in specific pathogen-free rats infected with mutans streptococci.
Caries research 1992;26(1):33-7.
1992: Takashi Ooshima; Toshiomi Yoshida; T Hashida; A Izumitani; Shizuo Sobue; Shigeyuki Hamada
Effects of hyposalivation on the oral microflora of rats fed sucrose or wheat flour diets.
Caries research 1992;26(2):124-31.
1992: Takashi Ooshima; Toshiomi Yoshida; W Aono; T Takei; A Izumitani; Shizuo Sobue; Shigeyuki Hamada
Changes with time in the oral microflora and dental caries induction in hyposalivated rats fed on sucrose diet.
Microbiology and immunology 1992;36(12):1223-31.
1992: Shigeyuki Hamada; Tomohiko Ogawa; H Shimauchi; Yutaka Kusumoto
Induction of mucosal and serum immune responses to a specific antigen of periodontal bacteria.
Advances in experimental medicine and biology 1992;327():71-81.
1991: Tomohiko Ogawa; T Mukai; K Yasuda; H Shimauchi; Y Toda; Shigeyuki Hamada
Distribution and immunochemical specificities of fimbriae of Porphyromonas gingivalis and related bacterial species.
Oral microbiology and immunology 1991;6(6):332-40.
1991: Tomohiko Ogawa; Yutaka Kusumoto; H Uchida; S Nagashima; H Ogo; Shigeyuki Hamada
Immunobiological activities of synthetic peptide segments of fimbrial protein from Porphyromonas gingivalis.
Biochemical and biophysical research communications 1991;180(3):1335-41.
1991: Shigeyuki Hamada; T Horikoshi; T Minami; Shigetada Kawabata; J Hiraoka; T Fujiwara; Takashi Ooshima
Oral passive immunization against dental caries in rats by use of hen egg yolk antibodies specific for cell-associated glucosyltransferase of Streptococcus mutans.
Infection and immunity 1991;59(11):4161-7.
1991: H Shimauchi; Tomohiko Ogawa; Shigeyuki Hamada
Immune response gene regulation of the humoral immune response to Porphyromonas gingivalis fimbriae in mice.
Immunology 1991;74(2):362-4.
1991: Tomohiko Ogawa; H Uchida; Yutaka Kusumoto; Y Mori; Y Yamamura; Shigeyuki Hamada
Increase in tumor necrosis factor alpha- and interleukin-6-secreting cells in peripheral blood mononuclear cells from subjects infected with Mycobacterium tuberculosis.
Infection and immunity 1991;59(9):3021-5.
1991: Takashi Ooshima; T Hashida; H Fuchihata; T Fujiwara; Toshiomi Yoshida; A Izumitani; Shizuo Sobue; Shigeyuki Hamada
Dental caries induction in hyposalivated rats.
Caries research 1991;25(2):138-42.
1991: Takashi Ooshima; A Izumitani; T Minami; T Fujiwara; Y Nakajima; Shigeyuki Hamada
Trehalulose does not induce dental caries in rats infected with mutans streptococci.
Caries research 1991;25(4):277-82.
1991: H Takada; J Mihara; Ichijiro Morisaki; Shigeyuki Hamada
Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides.
Infection and immunity 1991;59(1):295-301.
1990: Shigeyuki Hamada; T Fujiwara; H Shimauchi; Tomohiko Ogawa; T Nishihara; T Koga; T Nehashi; T Matsuno
Antimicrobial activities of thiolactomycin against gram-negative anaerobes associated with periodontal disease. f1.
Oral microbiology and immunology 1990;5(6):340-5.
1990: H Takada; H Hirai; T Fujiwara; T Koga; Tomohiko Ogawa; Shigeyuki Hamada
Bacteroides lipopolysaccharides (LPS) induce anaphylactoid and lethal reactions in LPS-responsive and -nonresponsive mice primed with muramyl dipeptide.
The Journal of infectious diseases 1990;162(2):428-34.
1990: T Minami; T Fujiwara; Takashi Ooshima; Y Nakajima; Shigeyuki Hamada
Interaction of structural isomers of sucrose in the reaction between sucrose and glucosyltransferases from mutans streptococci.
Oral microbiology and immunology 1990;5(4):189-94.
1990: T Fujiwara; Tomohiko Ogawa; S Sobue; Shigeyuki Hamada
Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains.
Journal of general microbiology 1990;136(2):319-26.
1990: K Kitamura; Ichijiro Morisaki; C Adachi; K Kato; J Mihara; Shizuo Sobue; Shigeyuki Hamada
Gingival overgrowth induced by cyclosporin A in rats.
Archives of oral biology 1990;35(6):483-6.
1990: Ichijiro Morisaki; J Mihara; K Kato; K Kitamura; C Adachi; Shizuo Sobue; Shigeyuki Hamada
Phenytoin-induced gingival overgrowth in rats infected with Streptococcus sobrinus 6715.
Archives of oral biology 1990;35(9):753-8.
1990: Shigeyuki Hamada; H Takada; Tomohiko Ogawa; T Fujiwara; J Mihara
Lipopolysaccharides of oral anaerobes associated with chronic inflammation: chemical and immunomodulating properties.
International reviews of immunology 1990;6(4):247-61.
1990: Tomohiko Ogawa; H Shimauchi; Yutaka Kusumoto; Shigeyuki Hamada
Humoral immune response to Bacteroides gingivalis fimbrial antigen in mice.
Immunology 1990;69(1):8-13.
1989: Tomohiko Ogawa; H Shimauchi; Shigeyuki Hamada
Mucosal and systemic immune responses in BALB/c mice to Bacteroides gingivalis fimbriae administered orally.
Infection and immunity 1989;57(11):3466-71.
1989: Shigeyuki Hamada; T Horikoshi; T Minami; N Okahashi; T Koga
Purification and characterization of cell-associated glucosyltransferase synthesizing water-insoluble glucan from serotype c Streptococcus mutans.
Journal of general microbiology 1989;135(Pt 2):335-44.
1988: Takashi Ooshima; T Fujiwara; T Takei; A Izumitani; Shizuo Sobue; Shigeyuki Hamada
The caries inhibitory effects of GOS-sugar in vitro and in rat experiments.
Microbiology and immunology 1988;32(11):1093-105.