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Toshiyuki Hamaoka

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Yasunari Morimoto; Yang Bian; Ping Gao; Yumi Yashiro-ohtani; Xu-Yu Zhou; Shiro Ono; Hirokazu Nakahara; Mikihiko Kogo; Toshiyuki Hamaoka; Hiromi Fujiwara
Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.
Noritami Takeuchi; Shin-Ichiro Hiraoka; Xu-Yu Zhou; Masakazu Nagafuku; Shiro Ono; Takahiro Tsujimura; Mitsuhiro Nakazawa; Yoshiaki Yura; Toshiyuki Hamaoka; Hiromi Fujiwara
Anti-HER-2/neu immune responses are induced before the development of clinical tumors but declined following tumorigenesis in HER-2/neu transgenic mice.
Woong-Ryeon Park; Masakiyo Nakahira; Naotoshi Sugimoto; Yang Bian; Yumi Yashiro-ohtani; Xu-Yu Zhou; Yi-Fu Yang; Toshiyuki Hamaoka; Hiromi Fujiwara
A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells.

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2005: Yasunari Morimoto; Yang Bian; Ping Gao; Yumi Yashiro-ohtani; Xu-Yu Zhou; Shiro Ono; Hirokazu Nakahara; Mikihiko Kogo; Toshiyuki Hamaoka; Hiromi Fujiwara
Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.
Journal of leukocyte biology 2005;78(3):753-61.
2004: Noritami Takeuchi; Shin-Ichiro Hiraoka; Xu-Yu Zhou; Masakazu Nagafuku; Shiro Ono; Takahiro Tsujimura; Mitsuhiro Nakazawa; Yoshiaki Yura; Toshiyuki Hamaoka; Hiromi Fujiwara
Anti-HER-2/neu immune responses are induced before the development of clinical tumors but declined following tumorigenesis in HER-2/neu transgenic mice.
Cancer research 2004;64(20):7588-95.
2004: Woong-Ryeon Park; Masakiyo Nakahira; Naotoshi Sugimoto; Yang Bian; Yumi Yashiro-ohtani; Xu-Yu Zhou; Yi-Fu Yang; Toshiyuki Hamaoka; Hiromi Fujiwara
A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells.
International immunology 2004;16(2):295-302.
2003: Masakazu Nagafuku; Kazuya Kabayama; Daisuke Oka; Akiko Kato; Shizue Tani-Ichi; Yukiko Shimada; Yoshiko Ohno-Iwashita; Sho Yamasaki; Takashi Saito; Kazuya Iwabuchi; Toshiyuki Hamaoka; Jin-ichi Inokuchi; Atsushi Kosugi
Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor.
The Journal of biological chemistry 2003;278(51):51920-7.
2003: Naoya Hatano; Yoshiko Mori; Masatsugu Oh-hora; Atsushi Kosugi; Takahiko Fujikawa; Naoya Nakai; Hitoshi Niwa; Jun-ichi Miyazaki; Toshiyuki Hamaoka; Masato Ogata
Essential role for ERK2 mitogen-activated protein kinase in placental development.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(11):847-56.
2003: Natsuko Tanimura; Masakazu Nagafuku; Douglas R Liddicoat; Toshiyuki Hamaoka; Atsushi Kosugi
Analysis of the mobility of signaling molecules in lymphocytes using fluorescence photobleaching techniques.
Science's STKE : signal transduction knowledge environment 2003;2003(185):pl10.
2003: Ping Gao; Xu-Yu Zhou; Yumi Yashiro-ohtani; Yi-Fu Yang; Naotoshi Sugimoto; Shiro Ono; Tsuyoshi Nakanishi; Satoshi Obika; Takeshi Imanishi; Takeshi Egawa; Takashi Nagasawa; Hiromi Fujiwara; Toshiyuki Hamaoka
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3.
Journal of leukocyte biology 2003;73(2):273-80.
2003: Natsuko Tanimura; Masakazu Nagafuku; Yasuko Minaki; Yukio Umeda; Fumie Hayashi; Junko Sakakura; Akiko Kato; Douglas R Liddicoat; Masato Ogata; Toshiyuki Hamaoka; Atsushi Kosugi
Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation.
The Journal of cell biology 2003;160(1):125-35.
2003: Naotoshi Sugimoto; Masakiyo Nakahira; Hyun-Jong Ahn; Mark Micallef; Toshiyuki Hamaoka; Masashi Kurimoto; Hiromi Fujiwara
Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18.
European journal of immunology 2003;33(1):243-51.
2002: Yasuhiro Uekusa; Ping Gao; Nobuya Yamaguchi; Michio Tomura; Takao Mukai; Chigusa Nakajima; Masayuki Iwasaki; Noritame Takeuchi; Takahiro Tsujimura; Mitsuhiro Nakazawa; Hiromi Fujiwara; Toshiyuki Hamaoka
A role for endogenous IL-12 in tumor immunity: IL-12 is required for the acquisition of tumor-migratory capacity by T cells and the development of T cell-accepting capacity in tumor masses.
Journal of leukocyte biology 2002;72(5):864-73.
2002: Koubun Yasuda; Masakazu Nagafuku; Takaki Shima; Masato Okada; Takeshi Yagi; Takenao Yamada; Yasuko Minaki; Akiko Kato; Shizue Tani-Ichi; Toshiyuki Hamaoka; Atsushi Kosugi
Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):2813-7.
2002: Yi-Fu Yang; Takao Mukai; Ping Gao; Nobuya Yamaguchi; Shiro Ono; Hiroshi Iwaki; Satoshi Obika; Takeshi Imanishi; Takahiro Tsujimura; Toshiyuki Hamaoka; Hiromi Fujiwara
A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses.
European journal of immunology 2002;32(8):2124-32.
2002: Yasuhiro Uekusa; Wen-gong Yu; Takao Mukai; Ping Gao; Nobuya Yamaguchi; Masako Murai; Kouji Matsushima; Satoshi Obika; Takeshi Imanishi; Yuji Higashibata; Shintaro Nomura; Yukihiko Kitamura; Hiromi Fujiwara; Toshiyuki Hamaoka
A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice.
Cancer research 2002;62(13):3751-8.
2002: Chigusa Nakajima; Takao Mukai; Nobuya Yamaguchi; Yasunari Morimoto; Woong-Ryeon Park; Masayuki Iwasaki; Ping Gao; Shiro Ono; Hiromi Fujiwara; Toshiyuki Hamaoka
Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation.
European journal of immunology 2002;32(6):1792-801.
2002: Xu-Yu Zhou; Yumi Yashiro-ohtani; Masakiyo Nakahira; Woong-Ryeon Park; Ryo Abe; Toshiyuki Hamaoka; Mayumi Naramura; Hua Gu; Hiromi Fujiwara
Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3847-54.
2002: Yohzo Uchida; Masato Ogata; Yoshiko Mori; Masatsugu Oh-hora; Naoya Hatano; Toshiyuki Hamaoka
Localization of PTP-FERM in nerve processes through its FERM domain.
Biochemical and biophysical research communications 2002;292(1):13-9.
2002: Cheung-Seog Park; Yi-Fu Yang; Xu-Yu Zhou; Kazuhito Toyooka; Yumi Yashiro-ohtani; Woong-Ryeon Park; Michio Tomura; Xu-Guang Tai; Toshiyuki Hamaoka; Hiromi Fujiwara
Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line.
International immunology 2002;14(3):259-66.
2002: Masakiyo Nakahira; Hyun-Jong Ahn; Woong-Ryeon Park; Ping Gao; Michio Tomura; Cheung-Seog Park; Toshiyuki Hamaoka; Tsunetaka Ohta; Masashi Kurimoto; Hiromi Fujiwara
Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1146-53.
2001: Masayuki Iwasaki; Tetsu Mukai; Chigusa Nakajima; Yi-Fu Yang; Ping Gao; Nobuya Yamaguchi; Michio Tomura; Hiromi Fujiwara; Toshiyuki Hamaoka
A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):6877-83.
2001: Yi-Fu Yang; Michio Tomura; Masayuki Iwasaki; Shiro Ono; Jian-Ping Zou; K Uno; Gene M Shearer; Hiromi Fujiwara; Toshiyuki Hamaoka
IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4+ and CD8+ T cells.
Journal of clinical immunology 2001;21(6):402-9.
2001: Tetsu Mukai; Masayuki Iwasaki; Ping Gao; Michio Tomura; Yumi Yashiro-ohtani; Shiro Ono; M Murai; Kouji Matsushima; Masashi Kurimoto; Mikihiko Kogo; T Matsuya; Hiromi Fujiwara; Toshiyuki Hamaoka
IL-12 plays a pivotal role in LFA-1-mediated T cell adhesiveness by up-regulation of CCR5 expression.
Journal of leukocyte biology 2001;70(3):422-30.
2001: Masayuki Iwasaki; Tetsu Mukai; Ping Gao; Woong-Ryeon Park; Chigusa Nakajima; Michio Tomura; Hiromi Fujiwara; Toshiyuki Hamaoka
A critical role for IL-12 in CCR5 induction on T cell receptor-triggered mouse CD4(+) and CD8(+) T cells.
European journal of immunology 2001;31(8):2411-20.
2001: Masakiyo Nakahira; Michio Tomura; Masayuki Iwasaki; Hyun-Jong Ahn; Yang Bian; Toshiyuki Hamaoka; Tsunetaka Ohta; Masashi Kurimoto; Hiromi Fujiwara
An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1306-12.
2001: Atsushi Kosugi; J Sakakura; Koubun Yasuda; Masato Ogata; Toshiyuki Hamaoka
Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts.
Immunity 2001;14(6):669-80.
2001: Woong-Ryeon Park; Cheung-Seog Park; Michio Tomura; Hyun-Jong Ahn; You Nakahira; Masayuki Iwasaki; Ping Gao; Ryo Abe; Toshiyuki Hamaoka; Hiromi Fujiwara
CD28 costimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells.
European journal of immunology 2001;31(5):1456-64.
2001: Chigusa Nakajima; Yasuhiro Uekusa; Masayuki Iwasaki; Nobuya Yamaguchi; Tetsu Mukai; Ping Gao; Michio Tomura; Shiro Ono; Takahiro Tsujimura; Hiromi Fujiwara; Toshiyuki Hamaoka
A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice.
Cancer research 2001;61(8):3399-405.
2001: Hiromi Fujiwara; Toshiyuki Hamaoka
Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression.
International immunopharmacology 2001;1(4):613-23.
2001: Yi-Fu Yang; Michio Tomura; Masayuki Iwasaki; Tetsu Mukai; Ping Gao; Shiro Ono; Jian-Ping Zou; Gene M Shearer; Hiromi Fujiwara; Toshiyuki Hamaoka
IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells.
Journal of clinical immunology 2001;21(2):116-25.
2001: Atsushi Kosugi; Fumie Hayashi; Douglas R Liddicoat; Koubun Yasuda; Shin-ichiroh Saitoh; Toshiyuki Hamaoka
A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation.
Immunology letters 2001;76(2):133-8.
2000: Yi-Fu Yang; Michio Tomura; Shiro Ono; Toshiyuki Hamaoka; Hiromi Fujiwara
Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells.
International immunology 2000;12(12):1669-75.
2000: Ping Gao; Yasuhiro Uekusa; Chigusa Nakajima; Masayuki Iwasaki; Masakiyo Nakahira; Yi-Fu Yang; Shiro Ono; Takahiro Tsujimura; Hiromi Fujiwara; Toshiyuki Hamaoka
Tumor vaccination that enhances antitumor T-cell responses does not inhibit the growth of established tumors even in combination with interleukin-12 treatment: the importance of inducing intratumoral T-cell migration.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(6):643-53.
2000: Koubun Yasuda; Atsushi Kosugi; Fumie Hayashi; Shin-ichiroh Saitoh; Masakazu Nagafuku; Yasuo Mori; Masato Ogata; Toshiyuki Hamaoka
Serine 6 of Lck tyrosine kinase: a critical site for Lck myristoylation, membrane localization, and function in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3226-31.
2000: Cheung-Seog Park; Woong-Ryeon Park; Naotoshi Sugimoto; Masakiyo Nakahira; Hyun-Jong Ahn; Toshiyuki Hamaoka; Tsunetaka Ohta; Masashi Kurimoto; Hiromi Fujiwara
Differential effects of N-acetyl-l-cysteine on IL-2- vs IL-12-driven proliferation of a T cell clone: implications for distinct signalling pathways.
Cytokine 2000;12(9):1419-22.
2000: T Nakanishi; A Hayashi; Jun Kunisawa; Yasuo Tsutsumi; K Tanaka; Yumi Yashiro-ohtani; M Nakanishi; Hiromi Fujiwara; Toshiyuki Hamaoka; Tadanori Mayumi
Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway.
European journal of immunology 2000;30(6):1740-7.
2000: Masayuki Iwasaki; Wen-gong Yu; Yasuhiro Uekusa; Chigusa Nakajima; Yi-Fu Yang; Ping Gao; R Wijesuriya; Hiromi Fujiwara; Toshiyuki Hamaoka
Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models.
International immunology 2000;12(5):701-9.
2000: Yasuhiro Uekusa; Minetaro Ogawa; Ping Gao; Masayuki Iwasaki; Shiro Ono; Takahiro Tsujimura; Mitsuhiro Nakazawa; Masayoshi Sakuda; B Clancy; Hiromi Fujiwara; Toshiyuki Hamaoka
The development of peritumoral stroma required for IL-12 induced tumor regression depends on the T cell/IFN-gamma-involving host-tumor interaction.
International journal of oncology 2000;16(4):805-14.
2000: Xu-Yu Zhou; Yumi Yashiro-ohtani; Kazuhito Toyo-Oka; Cheung-Seog Park; Xu-Guang Tai; Toshiyuki Hamaoka; Hiromi Fujiwara
CD5 costimulation up-regulates the signaling to extracellular signal-regulated kinase activation in CD4+CD8+ thymocytes and supports their differentiation to the CD4 lineage.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1260-8.
2000: Yumi Yashiro-ohtani; Xu-Yu Zhou; Kazuhito Toyo-Oka; Xu-Guang Tai; Cheung-Seog Park; Toshiyuki Hamaoka; Ryo Abe; Kensuke Miyake; Hiromi Fujiwara
Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1251-9.
1999: Kazuhito Toyo-Oka; Yumi Yashiro-ohtani; Cheung-Seog Park; Xu-Guang Tai; Kensuke Miyake; Toshiyuki Hamaoka; Hiromi Fujiwara
Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association.
International immunology 1999;11(12):2043-52.
1999: Atsushi Kosugi; Shin-ichiroh Saitoh; S Noda; Koubun Yasuda; Fumie Hayashi; M Ogata; Toshiyuki Hamaoka
Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation.
International immunology 1999;11(9):1395-401.
1999: Atsushi Hayashi; Tsuyoshi Nakanishi; Jun Kunisawa; Masuo Kondoh; Susumu Imazu; Yasuo Tsutsumi; Keiichi Tanaka; Hiromi Fujiwara; Toshiyuki Hamaoka; Tadanori Mayumi
A novel vaccine delivery system using immunopotentiating fusogenic liposomes.
Biochemical and biophysical research communications 1999;261(3):824-8.
1999: Masatsugu Oh-hora; Masato Ogata; Yasuo Mori; Masashi Adachi; K Imai; Atsushi Kosugi; Toshiyuki Hamaoka
Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1282-8.
1999: Masato Ogata; T Takada; Yasuo Mori; Yohzo Uchida; Tsuneharu Miki; A Okuyama; Atsushi Kosugi; M Sawada; Masatsugu Oh-hora; Toshiyuki Hamaoka
Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion.
The Journal of biological chemistry 1999;274(29):20717-24.
1999: Michio Tomura; Wen-gong Yu; Hyun-Jong Ahn; M Yamashita; Yi-Fu Yang; Shiro Ono; Toshiyuki Hamaoka; T Kawano; M Taniguchi; Y Koezuka; Hiromi Fujiwara
A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):93-101.
1999: Masato Ogata; T Takada; Yasuo Mori; Masatsugu Oh-hora; Yohzo Uchida; Atsushi Kosugi; K Miyake; Toshiyuki Hamaoka
Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells.
The Journal of biological chemistry 1999;274(18):12905-9.
1999: Minetaro Ogawa; K Umehara; Wen-gong Yu; Yasuhiro Uekusa; Chigusa Nakajima; Takahiro Tsujimura; T Kubo; Hiromi Fujiwara; Toshiyuki Hamaoka
A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression.
Cancer research 1999;59(7):1531-8.
1999: Masato Ogata; Masatsugu Oh-hora; Atsushi Kosugi; Toshiyuki Hamaoka
Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7.
Biochemical and biophysical research communications 1999;256(1):52-6.
1998: Hyun-Jong Ahn; Michio Tomura; Wen-gong Yu; Masayuki Iwasaki; Woong-Ryeon Park; Toshiyuki Hamaoka; Hiromi Fujiwara
Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5893-900.
1998: Kazuhito Toyooka; Xu-Guang Tai; Cheung-Seog Park; Y Yashiro; Toshiyuki Hamaoka; Hiromi Fujiwara
A caspase inhibitor protects thymocytes from diverse signal-mediated apoptosis but not from clonal deletion in fetal thymus organ culture.
Immunology letters 1998;63(2):83-9.
1998: R Wijesuriya; S Maruo; Jian-Ping Zou; Minetaro Ogawa; K Umehara; M Yamashita; Shiro Ono; Hiromi Fujiwara; Toshiyuki Hamaoka
B cell-mediated down-regulation of IFN-gamma and IL-12 production induced during anti-tumor immune responses in the tumor-bearing state.
International immunology 1998;10(8):1057-65.
1998: Cheung-Seog Park; Y Yashiro; Xu-Guang Tai; Kazuhito Toyo-Oka; Toshiyuki Hamaoka; Hideo Yagita; K Okumura; S Neben; Hiromi Fujiwara
Differential involvement of a Fas-CPP32-like protease pathway in apoptosis of TCR/CD9-costimulated, naive T cells and TCR-restimulated, activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5790-6.
1998: Minetaro Ogawa; Wen-gong Yu; K Umehara; Masayuki Iwasaki; R Wijesuriya; Takahiro Tsujimura; T Kubo; Hiromi Fujiwara; Toshiyuki Hamaoka
Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression.
Cancer research 1998;58(11):2426-32.
1998: Michio Tomura; Xu-Yu Zhou; S Maruo; Hyun-Jong Ahn; Toshiyuki Hamaoka; H Okamura; Kenji Nakanishi; Takeshi Tanimoto; Masashi Kurimoto; Hiromi Fujiwara
A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4738-46.
1998: Atsushi Kosugi; S Saitoh; S Noda; K Miyake; Y Yamashita; M Kimoto; Masato Ogata; Toshiyuki Hamaoka
Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex.
The Journal of biological chemistry 1998;273(20):12301-6.
1998: Michio Tomura; S Maruo; J Mu; Xu-Yu Zhou; Hyun-Jong Ahn; Toshiyuki Hamaoka; H Okamura; Kenji Nakanishi; S Clark; Masashi Kurimoto; Hiromi Fujiwara
Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3759-65.
1998: Y Yashiro; Xu-Guang Tai; Kazuhito Toyo-Oka; Cheung-Seog Park; Ryo Abe; Toshiyuki Hamaoka; Masatoshi Kobayashi; S Neben; Hiromi Fujiwara
A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory molecules.
European journal of immunology 1998;28(3):926-35.
1997: Tsuyoshi Nakanishi; Jun Kunisawa; Atsushi Hayashi; Yasuo Tsutsumi; K Kubo; Shinsaku Nakagawa; Hiromi Fujiwara; Toshiyuki Hamaoka; Tadanori Mayumi
Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins.
Biochemical and biophysical research communications 1997;240(3):793-7.
1997: Xu-Guang Tai; Kazuhito Toyooka; Y Yashiro; Ryo Abe; Cheung-Seog Park; Toshiyuki Hamaoka; Masatoshi Kobayashi; S Neben; Hiromi Fujiwara
CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3799-807.
1997: Wen-gong Yu; Minetaro Ogawa; J Mu; K Umehara; Takahiro Tsujimura; Hiromi Fujiwara; Toshiyuki Hamaoka
IL-12-induced tumor regression correlates with in situ activity of IFN-gamma produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways.
Journal of leukocyte biology 1997;62(4):450-7.
1997: Yi-Fu Yang; Jian-Ping Zou; J Mu; R Wijesuriya; Shiro Ono; T Walunas; J Bluestone; Hiromi Fujiwara; Toshiyuki Hamaoka
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages.
Cancer research 1997;57(18):4036-41.
1997: T Tsutsui; J Mu; Minetaro Ogawa; Wen-gong Yu; Takashi Suda; S Nagaga; F Saji; Y Murata; Hiromi Fujiwara; Toshiyuki Hamaoka
Administration of IL-12 induces a CD3+ CD4- CD8- B220+ lymphoid population capable of eliciting cytolysis against Fas-positive tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2599-605.
1997: Hyun-Jong Ahn; S Maruo; Michio Tomura; J Mu; Toshiyuki Hamaoka; Kenji Nakanishi; S Clark; Masashi Kurimoto; H Okamura; Hiromi Fujiwara
A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2125-31.
1997: Atsushi Kosugi; S Noda; S Saitoh; S Narumiya; M Ogata; Y Hashimoto; K Takase; T Saito; Toshiyuki Hamaoka
Subunit composition of the pre-T-cell receptor complex analysed by monoclonal antibody against the pre-T-cell receptor alpha chain.
Immunology 1997;91(4):618-22.
1997: Kazuhito Toyo-Oka; Xu-Guang Tai; Y Yashiro; Hyun-Jong Ahn; Ryo Abe; Toshiyuki Hamaoka; Masatoshi Kobayashi; S Neben; Hiromi Fujiwara
Synergy between CD28 and CD9 costimulation for naive T-cell activation.
Immunology letters 1997;58(1):19-23.
1997: Minetaro Ogawa; T Tsutsui; Jian-Ping Zou; J Mu; R Wijesuriya; Wen-gong Yu; S Herrmann; T Kubo; Hiromi Fujiwara; Toshiyuki Hamaoka
Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.
Cancer research 1997;57(11):2216-22.
1997: Xu-Guang Tai; Kazuhito Toyo-Oka; N Yamamoto; Y Yashiro; J Mu; Toshiyuki Hamaoka; Hiromi Fujiwara
Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4696-703.
1997: S Maruo; Hyun-Jong Ahn; Wen-gong Yu; Michio Tomura; M Wysocka; N Yamamoto; Masatoshi Kobayashi; Toshiyuki Hamaoka; G Trinchieri; H Fuijiwara
Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity.
Journal of leukocyte biology 1997;61(3):346-52.
1997: H Takenaka; S Maruo; N Yamamoto; M Wysocka; Shiro Ono; Masatoshi Kobayashi; Hideo Yagita; K Okumura; Toshiyuki Hamaoka; G Trinchieri; Hiromi Fujiwara
Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4.
Journal of leukocyte biology 1997;61(1):80-7.
1997: S Maruo; Masatsugu Oh-hora; Hyun-Jong Ahn; Shiro Ono; M Wysocka; Y Kaneko; Hideo Yagita; K Okumura; Hitoshi Kikutani; Tadamitsu Kishimoto; Masatoshi Kobayashi; Toshiyuki Hamaoka; G Trinchieri; Hiromi Fujiwara
B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):120-6.
1996: Tatsuo Furuyama; Shinobu Inagaki; Atsushi Kosugi; S Noda; S Saitoh; Masato Ogata; Y Iwahashi; N Miyazaki; Toshiyuki Hamaoka; Masaya Tohyama
Identification of a novel transmembrane semaphorin expressed on lymphocytes.
The Journal of biological chemistry 1996;271(52):33376-81.
1996: J Mu; Y Abe; T Tsutsui; N Yamamoto; Xu-Guang Tai; O Niwa; T Tsujimura; B Sato; H Terano; Hiromi Fujiwara; Toshiyuki Hamaoka
Inhibition of growth and metastasis of ovarian carcinoma by administering a drug capable of interfering with vascular endothelial growth factor activity.
Japanese journal of cancer research : Gann 1996;87(9):963-71.
1996: Xu-Guang Tai; Y Yashiro; Ryo Abe; K Toyooka; Clive R Wood; J Morris; A Long; S Ono; Masatoshi Kobayashi; Toshiyuki Hamaoka; S Neben; Hiromi Fujiwara
A role for CD9 molecules in T cell activation.
The Journal of experimental medicine 1996;184(2):753-8.
1996: Wen-gong Yu; N Yamamoto; H Takenaka; J Mu; Xu-Guang Tai; Jian-Ping Zou; M Ogawa; T Tsutsui; R Wijesuriya; R Yoshida; S Herrmann; Hiromi Fujiwara; Toshiyuki Hamaoka
Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12.
International immunology 1996;8(6):855-65.
1996: S Noda; Atsushi Kosugi; S Saitoh; S Narumiya; Toshiyuki Hamaoka
Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2.
The Journal of experimental medicine 1996;183(5):2355-60.
1996: S Maruo; Kazuhito Toyo-Oka; Masatsugu Oh-hora; Xu-Guang Tai; H Iwata; H Takenaka; S Yamada; Shiro Ono; Toshiyuki Hamaoka; Masatoshi Kobayashi; M Wysocka; G Trinchieri; Hiromi Fujiwara
IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1748-55.
1996: K Toyooka; S Maruo; T Iwahori; N Yamamoto; Xu-Guang Tai; Ryo Abe; Y Takahama; M Murakami; T Uede; Toshiyuki Hamaoka; Hiromi Fujiwara
CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism.
International immunology 1996;8(2):159-69.
1995: S Saitoh; Atsushi Kosugi; S Noda; N Yamamoto; Masato Ogata; Yasuhiro Minami; K Miyake; Toshiyuki Hamaoka
Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2).
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5574-81.
1995: J Mu; Jian-Ping Zou; N Yamamoto; T Tsutsui; Xu-Guang Tai; M Kobayashi; S Herrmann; Hiromi Fujiwara; Toshiyuki Hamaoka
Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.
Cancer research 1995;55(19):4404-8.
1995: Hiromi Fujiwara; Jian-Ping Zou; S Herrmann; Toshiyuki Hamaoka
A sequence of cellular and molecular events involved in IL12-induced tumour regression.
Research in immunology 1995;146(7-8):638-44.
1995: Atsushi Kosugi; S Noda; T Nagata-Narumiya; Toshiyuki Hamaoka
A physiological interaction of T cells and Mac-1+ cells is not necessary to induce the selective loss of CD3zeta chains in tumor-bearing state.
Immunology letters 1995;47(3):233-5.
1995: Jian-Ping Zou; N Yamamoto; T Fujii; H Takenaka; M Kobayashi; S H Herrmann; Stanley Wolf; Hiromi Fujiwara; Toshiyuki Hamaoka
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells.
International immunology 1995;7(7):1135-45.
1995: D Z Shao; S Yamada; F Hirayama; H Hirano; Shiro Ono; Toshiyuki Hamaoka
Modulation of B-cell abnormalities in lupus-prone (NZB x NZW)F1 mice by normal bone marrow-derived B-lineage cells.
Immunology 1995;85(1):16-25.
1995: S Noda; T Nagata-Narumiya; Atsushi Kosugi; S Narumiya; C Ra; Hiromi Fujiwara; Toshiyuki Hamaoka
Do structural changes of T cell receptor complex occur in tumor-bearing state?
Japanese journal of cancer research : Gann 1995;86(4):383-94.
1995: Masato Ogata; M Sawada; Y Fujino; Toshiyuki Hamaoka
cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain.
The Journal of biological chemistry 1995;270(5):2337-43.
1995: Hiromi Fujiwara; Toshiyuki Hamaoka
Regulatory mechanisms of antitumor T cell responses in the tumor-bearing state.
Immunologic research 1995;14(4):271-91.
1995: K Kuroda; K Yamashina; N Kitatani; A Kagishima; Toshiyuki Hamaoka; Yasuhiro Hosaka
Characterization of defectiveness in endogenous antigen presentation of novel murine cells established from methylcholanthrene-induced fibrosarcomas.
Immunology 1995;84(1):153-8.
1994: Masato Ogata; M Sawada; Atsushi Kosugi; Toshiyuki Hamaoka
Developmentally regulated expression of a murine receptor-type protein tyrosine phosphatase in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4478-87.
1994: M Sawada; Masato Ogata; Y Fujino; Toshiyuki Hamaoka
cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells.
Biochemical and biophysical research communications 1994;203(1):479-84.
1994: H Iwata; T Nagano; Kazuhito Toyo-Oka; H Hirose; Toshiyuki Hamaoka; Hiromi Fujiwara
Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin.
Transplantation proceedings 1994;26(2):851-4.
1994: Xu-Guang Tai; Y Saitoh; T Satoh; N Yamamoto; Y Kita; H Takenaka; Wen-gong Yu; Jian-Ping Zou; Toshiyuki Hamaoka; Hiromi Fujiwara
Thymic stromal cells eliminate T cells stimulated with antigen plus stromal Ia molecules through their cross-talk involving the production of interferon-gamma and nitric oxide.
Thymus 1994;24(1):41-56.
1994: Jian-Ping Zou; T Nagata; N Yamamoto; S Ono; H Fujiwara; Toshiyuki Hamaoka
Recovery of antitumor CD4+ T cell responsiveness, suppressed in the tumor-bearing state, by release from tumor burden.
Journal of cancer research and clinical oncology 1994;120(5):279-85.
1994: H Iwata; T Nagano; Kazuhito Toyo-Oka; H Hirose; Toshiyuki Hamaoka; Hiromi Fujiwara
Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin.
International immunology 1994;6(1):93-9.
1993: T Nagata; Jian-Ping Zou; N Yamamoto; Shiro Ono; Hiromi Fujiwara; Toshiyuki Hamaoka
Suppression of anti-tumor CD4+ T cell responsiveness in the tumor-bearing state and its recovery in in vitro culture free of tumor burden.
Japanese journal of cancer research : Gann 1993;84(11):1181-9.
1993: H Iwata; Satoru Kitagawa-Sakakida; S Sato; Atsushi Kosugi; H Hirose; Toshiyuki Hamaoka; G M Shearer; Hiromi Fujiwara
Suppression of allograft responses by combining donor alloantigen-specific intravenous presensitization with suboptimal doses of FK506.
Transplantation 1993;56(1):173-80.
1993: Xu-Guang Tai; Y Kita; K Toyooka; Toshiyuki Hamaoka; Hiromi Fujiwara
Thymic stroma-derived T-cell inhibitory factor (TSTIF). 2: TSTIF acts on the antigen-presenting cell to inhibit antigen-stimulated T-cell proliferation.
Thymus 1993;21(4):247-58.
1993: X F Li; H Takiuchi; Jian-Ping Zou; T Katagiri; N Yamamoto; T Nagata; Shiro Ono; Hiromi Fujiwara; Toshiyuki Hamaoka
Transforming growth factor-beta (TGF-beta)-mediated immunosuppression in the tumor-bearing state: enhanced production of TGF-beta and a progressive increase in TGF-beta susceptibility of anti-tumor CD4+ T cell function.
Japanese journal of cancer research : Gann 1993;84(3):315-25.
1992: M Sawada; J Nagamine; K Takeda; K Utsumi; Atsushi Kosugi; Y Tatsumi; Toshiyuki Hamaoka; K Miyake; K Nakajima; T Watanabe
Expression of VLA-4 on thymocytes. Maturation stage-associated transition and its correlation with their capacity to adhere to thymic stromal cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(11):3517-24.
1992: Atsushi Kosugi; A M Weissman; Masato Ogata; Toshiyuki Hamaoka; Hiromi Fujiwara
Instability of assembled T-cell receptor complex that is associated with rapid degradation of zeta chains in immature CD4+CD8+ thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9494-8.
1992: H Takiuchi; T Tada; X F Li; Masato Ogata; T Ikeda; S Fujimoto; Hiromi Fujiwara; Toshiyuki Hamaoka
Particular types of tumor cells have the capacity to convert transforming growth factor beta from a latent to an active form.
Cancer research 1992;52(20):5641-6.
1992: Y Takai; T Sakata; S Iwagami; Xu-Guang Tai; Y Kita; Toshiyuki Hamaoka; N Sakaguchi; H Yamagishi; Y Tsuruta; H Teraoka
Identification of IL-7-dependent bone marrow-derived Thy-1-B220- lymphoid cell clones that rearrange and express both Ig and T cell receptor genes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(5):1329-37.
1992: J Shimizu; T Suda; T Katagiri; Hiromi Fujiwara; Toshiyuki Hamaoka
Tumor-specific T cell lines: capacity to proliferate and produce interleukin 2 in response to various forms of tumor antigens.
Japanese journal of cancer research : Gann 1992;83(2):184-93.
1992: Jian-Ping Zou; J Shimizu; Kazuhiro Ikegame; N Yamamoto; Shiro Ono; Hiromi Fujiwara; Toshiyuki Hamaoka
Tumor-bearing mice exhibit a progressive increase in tumor antigen-presenting cell function and a reciprocal decrease in tumor antigen-responsive CD4+ T cell activity.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(2):648-55.
1992: S Hori; Satoru Kitagawa-Sakakida; H Iwata; T Ochiai; K Isono; Toshiyuki Hamaoka; Hiromi Fujiwara
Cell-cell interaction in graft rejection responses: induction of anti-allo-class I H-2 tolerance is prevented by immune responses against allo-class II H-2 antigens coexpressed on tolerogen.
The Journal of experimental medicine 1992;175(1):99-109.
1992: Jian-Ping Zou; J Shimizu; Kazuhiro Ikegame; H Takiuchi; Hiromi Fujiwara; Toshiyuki Hamaoka
Tumor-immunotherapy with the use of tumor-antigen-pulsed antigen-presenting cells.
Cancer immunology, immunotherapy : CII 1992;35(1):1-6.
1991: S Sato; H Iwata; Satoru Kitagawa-Sakakida; S Kokudo; Kiyotaka Okuno; Toshiyuki Hamaoka; Hiromi Fujiwara
The lymphoid cell populations required for induction of tolerance of different subsets of alloantigen-reactive T cells.
Transplantation 1991;52(5):862-7.
1991: Satoru Kitagawa-Sakakida; H Iwata; S Sato; J Shimizu; Toshiyuki Hamaoka; Hiromi Fujiwara
Heterogenous graft rejection pathways in class I major histocompatibility complex-disparate combinations and their differential susceptibility to immunomodulation induced by intravenous presensitization with relevant alloantigens.
The Journal of experimental medicine 1991;174(3):571-81.
1991: J Nagamine; K Takeda; Y Tatsumi; Masato Ogata; K Miyake; Toshiyuki Hamaoka; Hiromi Fujiwara
Role of a thymic stromal cell clone in inducing the stage-specific differentiation of various subpopulations of double negative thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1147-52.
1991: Taisei Nomura; Y Takahama; Tadashi Hongyo; H Takatera; Hidenori Inohara; H Fukushima; Shiro Ono; Toshiyuki Hamaoka
Rapid growth and spontaneous metastasis of human germinal tumors ectopically transplanted into scid (severe combined immunodeficiency) and scid-nudestreaker mice.
Japanese journal of cancer research : Gann 1991;82(6):701-9.
1991: K Kimura; H Matsubara; S Sogoh; Y Kita; T Sakata; Y Nishitani; S Watanabe; Toshiyuki Hamaoka; Hiromi Fujiwara
Role of glycosaminoglycans in the regulation of T cell proliferation induced by thymic stroma-derived T cell growth factor.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2618-24.
1991: Satoru Kitagawa-Sakakida; S Sato; T Azuma; J Shimizu; Toshiyuki Hamaoka; Hiromi Fujiwara
Heterogeneity of CD4+ T cells involved in anti-allo-class I H-2 immune responses. Functional discrimination between the major proliferating cells and helper cells assisting cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2513-21.
1991: J Shimizu; Jian-Ping Zou; Kazuhiro Ikegame; T Katagiri; Hiromi Fujiwara; Toshiyuki Hamaoka
Evidence for the functional binding in vivo of tumor rejection antigens to antigen-presenting cells in tumor-bearing hosts.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1708-14.
1991: J Shimizu; Jian-Ping Zou; Kazuhiro Ikegame; Hiromi Fujiwara; Toshiyuki Hamaoka
Antigen-presenting cells constitutively bind tumor antigens in the tumor-bearing state in vivo to construct an effective immunogenic unit.
Japanese journal of cancer research : Gann 1991;82(3):262-5.
1991: Satoru Kitagawa-Sakakida; S Sato; S Hori; Toshiyuki Hamaoka; Hiromi Fujiwara
Cell-cell interaction in graft-rejection responses: breakdown of tolerance to allo-class I H-2 antigens by helper T cells against other histocompatibility antigens simultaneously expressed on a graft.
Transplantation proceedings 1991;23(1 Pt 1):96-8.
1991: S Sato; Satoru Kitagawa-Sakakida; S Hori; T Azuma; Toshiyuki Hamaoka; Hiromi Fujiwara
Role of the thymus in repopulating alloantigen-reactive T cells after its functional elimination by intravenous presensitization with allogeneic cells.
Transplantation proceedings 1991;23(1 Pt 1):152-4.
1991: T Tada; S Ohzeki; K Utsumi; H Takiuchi; M Muramatsu; X F Li; J Shimizu; Hiromi Fujiwara; Toshiyuki Hamaoka
Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(3):1077-82.
1990: Hiromi Fujiwara; Masato Ogata; Y Mizushima; Y Tatsumi; Y Takai; Toshiyuki Hamaoka
Proliferation and differentiation of immature thymocytes induced by a thymic stromal cell clone.
Thymus 1990;16(3-4):159-72.
1990: Taisei Nomura; Y Takahama; Tadashi Hongyo; Hidenori Inohara; H Takatera; H Fukushima; Y Ishii; Toshiyuki Hamaoka
SCID (severe combined immunodeficiency) mice as a new system to investigate metastasis of human tumors.
Journal of radiation research 1990;31(3):288-92.
1990: Satoru Kitagawa-Sakakida; S Sato; S Hori; Toshiyuki Hamaoka; Hiromi Fujiwara
Induction of anti-allo-class I H-2 tolerance by inactivation of CD8+ helper T cells, and reversal of tolerance through introduction of third-party helper T cells.
The Journal of experimental medicine 1990;172(1):105-13.
1990: H Kosaka; H Matsubara; S Sogoh; Masato Ogata; Toshiyuki Hamaoka; Hiromi Fujiwara
An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination.
The Journal of experimental medicine 1990;172(1):395-8.
1990: K Utsumi; Y Takai; T Tada; S Ohzeki; Hiromi Fujiwara; Toshiyuki Hamaoka
Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):397-403.
1990: Satoru Kitagawa-Sakakida; S Sato; T Azuma; S Hori; Toshiyuki Hamaoka; Hiromi Fujiwara
Requirement of the thymus for the recovery of anti-alloantigen helper T cells from tolerance induced by intravenous presensitization with allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(11):4139-46.
1990: Y Tatsumi; A Kumanogoh; M Saitoh; Y Mizushima; K Kimura; S Suzuki; H Yagi; A Horiuchi; Masato Ogata; Toshiyuki Hamaoka
Differentiation of thymocytes from CD3-CD4-CD8- through CD3-CD4-CD8+ into more mature stages induced by a thymic stromal cell clone.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2750-4.
1990: H Kosaka; Masato Ogata; H Sano; S Sakuma; Y Mizushima; E Nakamura; H Teraoka; Toshiyuki Hamaoka; Hiromi Fujiwara
Thymic stroma-derived T cell growth factor (TSTGF): III. Its ability to promote T cell proliferation without stimulating interleukin 2- or 4-dependent autocrine mechanism.
Journal of leukocyte biology 1990;47(2):121-8.
1990: T Tada; H Sano; S Sato; J Shima; Hiromi Fujiwara; Toshiyuki Hamaoka
Immune dysfunction expressed selectively on L3T4+ T cells in the tumor-bearing state.
Journal of leukocyte biology 1990;47(2):149-57.
1990: Y Takahama; Shiro Ono; K Ishihara; M Muramatsu; Toshiyuki Hamaoka
Involvement of I-A-restricted B-B cell interaction in the polyclonal B cell differentiation induced by lipopolysaccharide.
Advances in experimental medicine and biology 1990;256():427-43.
1990: S Sugihara; S Maruo; T Tsujimura; O Tarutani; Y Kohno; Toshiyuki Hamaoka; Hiromi Fujiwara
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. III. Analysis of regulatory cells suppressing the induction of thyroiditis.
International immunology 1990;2(4):343-51.
1990: Y Takahama; Shiro Ono; K Ishihara; H Hirano; Toshiyuki Hamaoka
B-B cell interaction involved in polyclonal B cell activation is restricted by I-A but not by I-E molecules.
International immunology 1990;2(1):63-71.
1989: Y Takahama; Shiro Ono; K Ishihara; M Muramatsu; Toshiyuki Hamaoka
Disparate functions of I-A and I-E molecules on B cells as evidenced by the inhibition with anti-I-A and anti-I-E antibodies of polyclonal B cell activation.
European journal of immunology 1989;19(12):2227-35.
1989: S Sano; C Kiyotaki; Y Tatsumi; Hiromi Fujiwara; Toshiyuki Hamaoka
Cytotoxic T lymphocyte unresponsiveness induced by prolonged treatment with immobilized anti-CD3 antibody. Association of impairment of cytolytic activity with temporary depletion of intracellular protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2797-805.
1989: S Sugihara; S Maruo; T Tada; T Tsujimura; Y Kohno; Toshiyuki Hamaoka; Hiromi Fujiwara
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. II. Immunohistochemical studies on the thyroiditis lesion.
Regional immunology 1989;2(6):345-54.
1989: S Hori; S Sato; Satoru Kitagawa-Sakakida; T Azuma; S Kokudo; Toshiyuki Hamaoka; Hiromi Fujiwara
Tolerance induction of allo-class II H-2 antigen-reactive L3T4+ helper T cells and prolonged survival of the corresponding class II H-2-disparate skin graft.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1447-52.
1989: T Suda; J Shimizu; M Muramatsu; K Kimura; T O Yoshida; Y Fukami; Hiromi Fujiwara; Toshiyuki Hamaoka
The tumor rejection antigen separated from Rous sarcoma virus-induced murine fibrosarcoma exhibits a molecular weight of approximately 60 kD but differs from functional pp60src.
Japanese journal of cancer research : Gann 1989;80(9):879-86.
1989: T Azuma; S Sato; Satoru Kitagawa-Sakakida; S Hori; S Kokudo; Toshiyuki Hamaoka; Hiromi Fujiwara
Tolerance induction of allo-class I H-2 antigen-reactive Lyt-2+ helper T cells and prolonged survival of the corresponding class I H-2-disparate skin graft.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):1-8.
1989: H Kosaka; Masato Ogata; I Hikita; S Maruo; S Sugihara; H Matsubara; Yoshimi Takai; Toshiyuki Hamaoka; Hiromi Fujiwara
Model for clonal elimination in the thymus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3773-7.
1989: Toshiyuki Hamaoka
[Future perspectives on tumor-specific immunotherapy using hapten-reactive T cell activity].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(4 Pt 2-1):886-96.
1989: Hiromi Fujiwara; T Suda; J Shimizu; M Muramatsu; K Kimura; Toshiyuki Hamaoka
[Biochemical characterization of tumor rejection antigen (TRA) and genetic control in anti-TRA immune responses].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):646-52.
1989: Y Mizushima; M Saitoh; Masato Ogata; H Kosaka; Y Tatsumi; C Kiyotaki; Toshiyuki Hamaoka; Hiromi Fujiwara
Thymic stroma-derived T cell growth factor (TSTGF). IV. Capacity of TSTGF to promote the growth of L3T4- Lyt-2- thymocytes by synergy with phorbol myristate acetate or various IL.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(4):1195-202.
1989: J Shimizu; T Suda; T Yoshioka; Atsushi Kosugi; Hiromi Fujiwara; Toshiyuki Hamaoka
Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):1053-9.
1989: Masato Ogata; H Matsubara; Y Takai; H Kosaka; T Katagiri; H Sano; K Ishimura; H Fujita; Toshiyuki Hamaoka; Hiromi Fujiwara
Capacities of a newly established thymic stromal cell clone to express Ia antigens and to produce interleukin-6, colony-stimulating factor, and thymic stroma-derived T-cell growth factor.
Journal of leukocyte biology 1989;45(1):69-78.
1989: Y Takahama; Shiro Ono; K Ishihara; Toshiyuki Hamaoka
Cluster formation among small resting B lymphocytes leading to B cell activation.
International immunology 1989;1(1):36-42.
1988: Shinya Murakami; Shiro Ono; N Harada; Y Hara; Y Katoh; K Dobashi; K Takatsu; Toshiyuki Hamaoka
T-cell-derived factor B151-TRF1/IL-5 activates blastoid cells among unprimed B cells to induce a polyclonal differentiation into immunoglobulin M-secreting cells.
Immunology 1988;65(2):221-8.
1988: M Mori; K Tajima; Jun-ichiro Miyagawa; M Shimizu; K Mashita; S Sugihara; Toshiyuki Hamaoka; Hiromi Fujiwara; S Tarui
Release of 3,5,3'-triiodothyronine, thyroxine and thyroglobulin from TSH-stimulated mouse thyroids in the perifusion system.
Experientia 1988;44(9):766-8.
1988: S Sato; Masato Ogata; H Sano; Y Mizushima; M Muramatsu; H Doi; T Itoh; Toshiyuki Hamaoka; Hiromi Fujiwara
Thymic stroma-derived T-cell growth factor (TSTGF): II. Biochemical and functional characterization.
Journal of leukocyte biology 1988;44(3):149-57.
1988: S Sato; T Azuma; J Shimizu; J Shima; Satoru Kitagawa-Sakakida; Toshiyuki Hamaoka; Hiromi Fujiwara
Property of class I H-2 alloantigen-reactive Lyt-2+ helper T cell subset. Abrogation of its proliferative and IL-2-producing capacities by intravenous injection of class I H-2-disparate allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):721-7.
1988: T Suda; S Sano; S Hori; T Azuma; N Tateishi; Toshiyuki Hamaoka; Hiromi Fujiwara
Prevention of suppression of alloreactive capacity following intravenous injection of neuraminidase-treated allogeneic cells by co-injection of agents competing for asialoglycoprotein receptor.
Regional immunology 1988;1(1):24-31.
1988: H Sano; S Sato; J Shima; T Tada; Hiromi Fujiwara; Toshiyuki Hamaoka
Selective suppression of the generation of anti-tumor L3T4+ but not of Lyt-2+ T cell-mediated immunity in the tumor-bearing state.
Japanese journal of cancer research : Gann 1988;79(7):857-65.
1988: S Sugihara; Y Izumi; T Yoshioka; H Yagi; T Tsujimura; O Tarutani; Y Kohno; Shinya Murakami; Toshiyuki Hamaoka; Hiromi Fujiwara
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):105-13.
1988: T Suda; J Shimizu; Y Mizushima; Hiromi Fujiwara; Toshiyuki Hamaoka
Separation of the tumor rejection antigen of Rous sarcoma virus-induced murine fibrosarcoma.
Japanese journal of cancer research : Gann 1988;79(3):365-74.
1988: S Sato; J H Qian; S Kokudo; R Ikegami; T Suda; Toshiyuki Hamaoka; Hiromi Fujiwara
Studies on the induction of tolerance to alloantigens. III. Induction of antibodies directed against alloantigen-specific delayed-type hypersensitivity T cells by a single injection of allogeneic lymphocytes via portal venous route.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(3):717-22.
1988: S Kokudo; S Sato; J H Qian; K Wada; R Ikegami; Toshiyuki Hamaoka; Hiromi Fujiwara
Tolerance induction of alloreactivity by portal venous inoculation with allogeneic cells followed by the injection of cyclophosphamide. II. Cellular and molecular mechanisms underlying tolerance.
Microbiology and immunology 1988;32(3):283-92.
1988: Toshiyuki Hamaoka; J Shimizu; T Suda; Hiromi Fujiwara
Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.
Princess Takamatsu symposia 1988;19():265-75.
1988: Hiromi Fujiwara; M Ogata; Y Mizushima; H Kosaka; H Matsubara; Yoshimi Takai; Toshiyuki Hamaoka
Thymic stroma-derived T cell growth factor: its role in the growth of immature thymocytes and T cell repertoire selection.
Princess Takamatsu symposia 1988;19():115-26.
1988: K Sakamoto; Hiromu Nakajima; J Shimizu; T Katagiri; C Kiyotaki; Hiromi Fujiwara; Toshiyuki Hamaoka
The mode of recognition of tumor antigens by noncytolytic-type antitumor T cells: role of antigen-presenting cells and their surface class I and class II H-2 molecules.
Cancer immunology, immunotherapy : CII 1988;27(3):261-6.
1988: K Sakamoto; T Yoshioka; J Shimizu; S Sato; Hiromu Nakajima; Hiromi Fujiwara; Toshiyuki Hamaoka
Mechanisms for recognition of tumor antigens and mediation of anti-tumor effect by noncytolytic Lyt-2+ T cell subset.
Japanese journal of cancer research : Gann 1988;79(1):99-108.
1988: T Yoshioka; S Sato; Masato Ogata; K Sakamoto; H Sano; J Shima; H Yamamoto; Hiromi Fujiwara; Toshiyuki Hamaoka
Mediation of in vivo tumor-neutralizing activity by Lyt-2+ as well as L3T4+ T cell subsets.
Japanese journal of cancer research : Gann 1988;79(1):91-8.
1988: J Shima; T Yoshioka; Hiromu Nakajima; Hiromi Fujiwara; Toshiyuki Hamaoka
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. III. Eradication of disseminated murine chronic leukemia cells by utilizing MDP hapten-reactive helper T-cell activity.
Cancer immunology, immunotherapy : CII 1988;26(1):43-7.
1987: S Sano; T Suda; J H Qian; S Sato; R Ikegami; Toshiyuki Hamaoka; Hiromi Fujiwara
Abrogation of the capacity of delayed-type hypersensitivity responses to alloantigens by intravenous injection of neuraminidase-treated allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(11):3652-9.
1987: Atsushi Kosugi; T Yoshioka; T Suda; H Sano; Y Takahama; Hiromi Fujiwara; Toshiyuki Hamaoka
The activation of L3T4+ helper T cells assisting the generation of anti-tumor Lyt-2+ cytotoxic T lymphocytes: requirement of Ia-positive antigen-presenting cells for processing and presentation of tumor antigens.
Journal of leukocyte biology 1987;42(6):632-41.
1987: Shiro Ono; Y Takahama; Toshiyuki Hamaoka
Ia-restricted B-B cell interaction. I. The MHC haplotype of bone marrow cells present during B cell ontogeny dictates the self-recognition specificity of B cells in the polyclonal B cell activation by a B cell differentiation factor, B151-TRF2.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3213-23.
1987: Y Mizushima; H Kosaka; S Sakuma; K Kanda; K Itoh; T Osugi; A Mizushima; Toshiyuki Hamaoka; H Yoshida; K Sobue
Cyclosporin A inhibits late steps of T lymphocyte activation after transmembrane signaling.
Journal of biochemistry 1987;102(5):1193-201.
1987: Masato Ogata; S Sato; H Sano; Toshiyuki Hamaoka; H Doi; Kenji Nakanishi; Y Asano; T Itoh; Hiromi Fujiwara
Thymic stroma-derived T cell growth factor (TSTGF). I. Functional distinction of TSTGF from interleukins 2 and 4 and its preferential growth-promoting effect on helper T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2675-82.
1987: S Kokudo; J H Qian; Hiromi Fujiwara; Toshiyuki Hamaoka
Suppressive effect of portal venous inoculation with tumor cells on the anti-tumor immune potential.
Japanese journal of cancer research : Gann 1987;78(9):946-51.
1987: J H Qian; S Kokudo; S Sato; Toshiyuki Hamaoka; Hiromi Fujiwara
Tolerance induction of alloreactivity by portal venous inoculation with allogeneic cells followed by the injection of cyclophosphamide. I. Specific suppression of alloreactive cytotoxic and delayed-type hypersensitivity responses as well as allograft rejection.
Transplantation 1987;43(4):538-43.
1987: J Shima; T Yoshioka; Atsushi Kosugi; Masato Ogata; Hiromi Fujiwara; Toshiyuki Hamaoka; S Ueda; S Kato
Differential ability of tumor-unique and cross-reactive antigen(s) on two murine hepatoma cell lines to induce Lyt-1+2- T cells responsible for in vivo protective immunity.
Biken journal 1987;30(1):1-8.
1987: S Sano; Y Izumi; S Sugihara; Hiromu Nakajima; Hiromi Fujiwara; Toshiyuki Hamaoka
The generation of tumor-specific in vivo protective immunity in the tumor mass from mice rendered tolerant to tumor antigens.
Cancer immunology, immunotherapy : CII 1987;25(2):105-10.
1987: J Shimizu; M Ogata; J H Qian; S Sato; S Kokudo; Toshiyuki Hamaoka; Hiromi Fujiwara
Immunogenetic analysis of tolerance induction in anti-alloantigen delayed type hypersensitivity responses by portal venous pre-inoculation with allogeneic cells.
Microbiology and immunology 1987;31(4):367-74.
1987: K Miyake; S Hayashi; S Ono; Toshiyuki Hamaoka
The origin of antibody-forming cells detected in the bone marrow after thymus-independent antigen-stimulation and abnormality in migration of B cells of X-linked immunodeficient CBA/N mice.
Microbiology and immunology 1987;31(8):821-9.
1987: Hiromu Nakajima; Y Izumi; S Sugihara; Y Satoh; S Isumi; T Gotoh; Hiromi Fujiwara; Toshiyuki Hamaoka
Studies on macrophage-activating factor (MAF) in antitumor immune responses. II. Molecular characterization of MAF produced by the tumor-immune Lyt-1+2- T cell subset.
Cancer immunology, immunotherapy : CII 1987;25(3):201-8.
1987: C Kiyotaki; T Katagiri; Y Tatsumi; H Fujiwara; Toshiyuki Hamaoka
Establishment of murine macrophage hybridoma clones capable of acquiring tumoricidal activity upon activation with recombinant interferon-gamma and lipopolysaccharide.
Journal of cancer research and clinical oncology 1987;113(4):383-6.
1987: H Sano; Atsushi Kosugi; S Sano; Hiromi Fujiwara; Toshiyuki Hamaoka
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. II. Establishment of tumor-specific immunotherapy models utilizing MDP hapten-reactive helper T cell activity.
Cancer immunology, immunotherapy : CII 1987;25(3):180-4.
1987: Hiromi Fujiwara; J Shima; H Sano; Atsushi Kosugi; Hiromu Nakajima; Toshiyuki Hamaoka
Tumor-specific immunotherapy by active immunization with haptenic muramyl dipeptide derivative-coupled tumor cells.
Progress in clinical and biological research 1987;244():335-44.
1986: Atsushi Kosugi; J Shima; H Sano; M Ogata; T Kusama; Hiromi Fujiwara; Toshiyuki Hamaoka
Cross-reactivity between haptenic muramyl di- or tripeptide derivatives and Mycobacterium bovis BCG: potential application for enhancing tumor immunity.
Infection and immunity 1986;54(3):768-73.
1986: Hiromi Fujiwara; J H Qian; S Satoh; S Kokudo; R Ikegami; Toshiyuki Hamaoka
Studies on the induction of tolerance to alloantigens. II. The generation of serum factor(s) able to transfer alloantigen-specific tolerance for delayed-type hypersensitivity by portal venous inoculation with allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(8):2763-8.
1986: Hiromi Fujiwara; T Yoshioka; J Shima; Atsushi Kosugi; K Itoh; Toshiyuki Hamaoka
Helper T cells against tumor-associated antigens (TAA): preferential induction of helper T cell activities involved in anti-TAA cytotoxic T lymphocyte and antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(7):2715-9.
1985: Toshiyuki Hamaoka; Y Takai; Atsushi Kosugi; Y Mizushima; J Shima; T Kusama; Hiromi Fujiwara
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. I. Synthesis of a novel haptenic MDP derivative cross-reactive with Bacillus Calmette Guerin and its application to enhanced induction of tumor immunity.
Cancer immunology, immunotherapy : CII 1985;20(3):183-8.