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Trevor Hambley
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14
Hall, Matthew
10
Lay, Peter
9
Fenton, Ronald
9
Diakos, Connie
7
Kennedy, Brendan
6
Zhang, Mei
6
Failes, Timothy
6
Callaghan, Richard
6
Davies, Murray
6
McKeage, Mark
5
Beale, Philip
5
Berners-Price, Susan
5
Mellor, Howard
5
Messerle, Barbara
4
Modok, Szabolcs
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All Publications
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2009: Klein Alice V; Hambley Trevor W
Platinum drug distribution in cancer cells and tumors.
Chemical reviews 2009;109(10):4911-20.
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2009: New Elizabeth J; Roche Cécile; Madawala Romanthi; Zhang Jenny Z; Hambley Trevor W
Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells.
Journal of inorganic biochemistry 2009;103(8):1120-5.
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2009: Diakos Connie I; Zhang Mei; Beale Philip J; Fenton Ronald R; Hambley Trevor W
Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtCl2(R-dimepyrr)] (R-dimepyrr=N-dimethyl-2(R)-aminomethylpyrrolidine).
European journal of medicinal chemistry 2009;44(7):2807-14.
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2009: Bryce Nicole S; Zhang Jenny Z; Whan Renee M; Yamamoto Natsuho; Hambley Trevor W
Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models.
Chemical communications (Cambridge, England) 2009;(19):2673-5.
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2009: New Elizabeth J; Duan Ran; Zhang Jenny Z; Hambley Trevor W
Investigations using fluorescent ligands to monitor platinum(IV) reduction and platinum(II) reactions in cancer cells.
Dalton transactions (Cambridge, England : 2003) 2009;(16):3092-101.
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2009: Diakos Connie I; Messerle Barbara A; Murdoch P del Socorro; Parkinson John A; Sadler Peter J; Fenton Ronald R; Hambley Trevor W
Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A x T-rich 14-mer DNA duplex.
Inorganic chemistry 2009;48(7):3047-56.
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2009: Hambley Trevor W; Hait William N
Is anticancer drug development heading in the right direction?
Cancer research 2009;69(4):1259-62.
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2009: Whan Renee M; Messerle Barbara A; Hambley Trevor W
Binding of [Pt(1C3)(dien)](2+) to the duplex DNA oligonucleotide 5'-d(TGGCCA)-3': the effect of an appended positive charge on the orientation and location of anthraquinone intercalation.
Dalton transactions (Cambridge, England : 2003) 2009;(6):932-9.
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2009: Er Hui Meng; Hambley Trevor W
Enantioselectivity and stereoselectivity in the reactions of the enantiomers of the platinum complex [PtCl2(ahaz)] (ahaz=3(R)- or 3(S)-aminohexahydroazepine) with DNA.
Journal of inorganic biochemistry 2009;103(2):168-73.
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2008: Davies Murray S; Hall Matthew D; Berners-Price Susan J; Hambley Trevor W
[1H, 15N] heteronuclear single quantum coherence NMR study of the mechanism of aquation of platinum(IV) ammine complexes.
Inorganic chemistry 2008;47(17):7673-80.
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2008: Yamamoto Natsuho; Danos Sarah; Bonnitcha Paul D; Failes Timothy W; New Elizabeth J; Hambley Trevor W
Cellular uptake and distribution of cobalt complexes of fluorescent ligands.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(6):861-71.
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2007: Hambley Trevor W
Chemistry. Metal-based therapeutics.
Science (New York, N.Y.) 2007;318(5855):1392-3.
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2007: Hambley Trevor W
Developing new metal-based therapeutics: challenges and opportunities.
Dalton transactions (Cambridge, England : 2003) 2007;(43):4929-37.
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2007: Alderden Rebecca A; Mellor Howard R; Modok Szabolcs; Hall Matthew D; Sutton Stephen R; Newville Matthew G; Callaghan Richard; Hambley Trevor W
Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both platinum(II) and platinum(IV) complexes.
Journal of the American Chemical Society 2007;129(44):13400-1.
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2007: Hocking Rosalie K; Deeth Robert J; Hambley Trevor W
DFT study of the systematic variations in metal-ligand bond lengths of coordination complexes: the crucial role of the condensed phase.
Inorganic chemistry 2007;46(20):8238-44.
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2007: Hall Matthew D; Failes Timothy W; Yamamoto Natsuho; Hambley Trevor W
Bioreductive activation and drug chaperoning in cobalt pharmaceuticals.
Dalton transactions (Cambridge, England : 2003) 2007;(36):3983-90.
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2007: Hall Matthew D; Mellor Howard R; Callaghan Richard; Hambley Trevor W
Basis for design and development of platinum(IV) anticancer complexes.
Journal of medicinal chemistry 2007;50(15):3403-11.
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2007: Modok S; Scott R; Alderden R A; Hall M D; Mellor H R; Bohic S; Roose T; Hambley T W; Callaghan R
Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model.
British journal of cancer 2007;97(2):194-200.
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2007: Failes Timothy W; Hambley Trevor W
Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat.
Journal of inorganic biochemistry 2007;101(3):396-403.
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2007: Failes Timothy W; Cullinane Carleen; Diakos Connie I; Yamamoto Natsuho; Lyons J Guy; Hambley Trevor W
Studies of a cobalt(III) complex of the MMP inhibitor marimastat: a potential hypoxia-activated prodrug.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(10):2974-82.
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2006: Diakos Connie I; Fenton Ronald R; Hambley Trevor W
DNA-binding and molecular mechanics modelling studies of the bulky chiral platinum(II) complex [PtCl(2)(mepyrr)] (mepyrr=N-methyl-2-aminomethylpyrrolidine).
Journal of inorganic biochemistry 2006;100(12):1965-73.
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2006: Battle Andrew R; Choi Robin; Hibbs David E; Hambley Trevor W
Platinum(IV) analogues of AMD473 (cis-[PtCl2(NH3)(2-picoline)]): preparative, structural, and electrochemical studies.
Inorganic chemistry 2006;45(16):6317-22.
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2006: Hall Matthew D; Alderden Rebecca A; Zhang Mei; Beale Philip J; Cai Zhonghou; Lai Barry; Stampfl Anton P J; Hambley Trevor W
The fate of platinum(II) and platinum(IV) anti-cancer agents in cancer cells and tumours.
Journal of structural biology 2006;155(1):38-44.
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2006: Bonnitcha Paul D; Hall Matthew D; Underwood Clare K; Foran Garry J; Zhang Mei; Beale Philip J; Hambley Trevor W
XANES investigation of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes.
Journal of inorganic biochemistry 2006;100(5-6):963-71.
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2006: Failes Timothy W; Hambley Trevor W
Models of hypoxia activated prodrugs: Co(III) complexes of hydroxamic acids.
Dalton transactions (Cambridge, England : 2003) 2006;(15):1895-901.
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2006: Alderden R A; Mellor H R; Modok S; Hambley T W; Callaghan R
Cytotoxic efficacy of an anthraquinone linked platinum anticancer drug.
Biochemical pharmacology 2006;71(8):1136-45.
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2005: Mellor H R; Snelling S; Hall M D; Modok S; Jaffar M; Hambley T W; Callaghan R
The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes.
Biochemical pharmacology 2005;70(8):1137-46.
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2005: Malina Jaroslav; Vojtiskova Marie; Brabec Viktor; Diakos Connie I; Hambley Trevor W
DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins.
Biochemical and biophysical research communications 2005;332(4):1034-41.
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2005: Hocking Rosalie K; Hambley Trevor W
Structural measures of element-oxygen bond covalency from the changes to the delocalisation of the carboxylate ligand.
Dalton transactions (Cambridge, England : 2003) 2005;(5):969-78.
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2005: Ramadan Saadallah; Bonin Antonio M; Kennedy Brendan J; Hambley Trevor W; Lay Peter A
Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers.
Chemical research in toxicology 2005;18(2):123-8.
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2004: Hall Matthew D; Amjadi Shahriar; Zhang Mei; Beale Philip J; Hambley Trevor W
The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines.
Journal of inorganic biochemistry 2004;98(10):1614-24.
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2004: Allan Robin D; Greenwood Jeremy R; Hambley Trevor W; Hanrahan Jane R; Hibbs David E; Itani Samia; Tran Hue W; Turner Peter
Studies on pyridazine azide cyclisation reactions.
Organic & biomolecular chemistry 2004;2(12):1782-8.
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2004: Ramadan Saadallah; Hambley Trevor W; Kennedy Brendan J; Lay Peter A
NMR spectroscopic characterization of copper(II) and zinc(II) complexes of indomethacin.
Inorganic chemistry 2004;43(9):2943-6.
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2004: Levina Aviva; Codd Rachel; Foran Garry J; Hambley Trevor W; Maschmeyer Thomas; Masters Anthony F; Lay Peter A
X-ray absorption spectroscopic studies of chromium(V/IV/III)- 2-ethyl-2-hydroxybutanoato(2-/1-) complexes.
Inorganic chemistry 2004;43(3):1046-55.
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2004: Hall Matthew D; Martin Catherine; Ferguson David J P; Phillips Roger M; Hambley Trevor W; Callaghan Richard
Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models.
Biochemical pharmacology 2004;67(1):17-30.
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2004: Dillon Carolyn T; Hambley Trevor W; Kennedy Brendan J; Lay Peter A; Weder Jane E; Zhou Qingdi
Copper and zinc complexes as antiinflammatory drugs.
Metal ions in biological systems 2004;41():253-77.
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2004: Hall Matthew D; Dolman Rachael C; Hambley Trevor W
Platinum(IV) anticancer complexes.
Metal ions in biological systems 2004;42():297-322.
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2003: Zhou Qingdi; Hambley Trevor W; Kennedy Brendan J; Lay Peter A
XAFS studies of anti-inflammatory dinuclear and mononuclear Zn(II) complexes of indomethacin.
Inorganic chemistry 2003;42(25):8557-66.
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2003: Hall Matthew D; Dillon Carolyn T; Zhang Mei; Beale Philip; Cai Zhonghou; Lai Barry; Stampfl Anton P J; Hambley Trevor W
The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(7):726-32.
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2003: Hall Matthew D; Foran Garry J; Zhang Mei; Beale Philip J; Hambley Trevor W
XANES determination of the platinum oxidation state distribution in cancer cells treated with platinum(IV) anticancer agents.
Journal of the American Chemical Society 2003;125(25):7524-5.
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2003: Munk Vivienne P; Diakos Connie I; Ellis Leanne T; Fenton Ronald R; Messerle Barbara A; Hambley Trevor W
Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473.
Inorganic chemistry 2003;42(11):3582-90.
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2003: Underwood C K; Min D; Lyons J G; Hambley T W
The interaction of metal ions and Marimastat with matrix metalloproteinase 9.
Journal of inorganic biochemistry 2003;95(2-3):165-70.
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2003: Brown Kylie N; Geue Rodney J; Hambley Trevor W; Hockless David C R; Rae A David; Sargeson Alan M
Specificity in template syntheses of hexaaza-macrobicyclic cages: [Pt(Me5-tricosatrieneN6)]4+ and [Pt(Me5-tricosaneN6)]4+.
Organic & biomolecular chemistry 2003;1(9):1598-608.
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2003: Hocking Rosalie K; Hambley Trevor W
Structural measure of metal-ligand covalency from the bonding in carboxylate ligands.
Inorganic chemistry 2003;42(9):2833-5.
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2003: Dillon Carolyn T; Hambley Trevor W; Kennedy Brendan J; Lay Peter A; Zhou Qingdi; Davies Neal M; Biffin J Ray; Regtop Hubert L
Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin.
Chemical research in toxicology 2003;16(1):28-37.
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2002: Munk Vivienne P; Diakos Connie I; Messerle Barbara A; Fenton Ronald R; Hambley Trevor W
Stereospecificity and enantioselectivity in the binding of the platinum(II) complex [PtCl2(tmdz)] (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) to dinucleotides and oligonucleotides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(23):5486-93.
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2002: Field Leslie D; Hambley Trevor W; Humphrey Paul A; Masters Anthony F; Turner Peter
X-ray crystal structure of (eta(5)-pentaphenylcyclopentadienyl)[1-(eta(5/6)-phenyl)-2,3,4,5-tetraphenylcyclopentadienyl]iron(II), [Fe(eta(5)-C(5)Ph(5))[(eta(5/6)-C(6)H(5))C(5)Ph(4)]], a linkage isomer of decaphenylferrocene.
Inorganic chemistry 2002;41(18):4618-20.
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2002: Davies Murray S; Wong Pong Nai; Battle Andrew R; Haddad Gabi; McKeage Mark J; Hambley Trevor W
Examination of the effects of oxidation and ring closure on the cytotoxicities of the platinum complexes of N-(2-hydroxyethyl)ethane-1,2-diamine and ethane-1,2-diamine-N,N'-diacetic acid.
Journal of inorganic biochemistry 2002;91(1):205-11.
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2002: Hocking Rosalie K; Hambley Trevor W
Statistical and molecular mechanics analysis of the effects of changing donor type on bond length in the two series [Co(III)N(n)O(6-n)] and [Ni(II)N(n)O(6-n)] (n = 0-6): a new route to bond-stretch Parameters.
Inorganic chemistry 2002;41(10):2660-6.
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2002: Cullinane Carleen; Deacon Glen B; Drago Penny R; Hambley Trevor W; Nelson Keith T; Webster Lorraine K
Preparation and cell growth inhibitory activity of [PtR(2)L(2)] (R=polyfluorophenyl, L(2)=diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)(2)) and the X-ray crystal structure of [Pt(C(6)F(5))(2)(cis-chxn)].
Journal of inorganic biochemistry 2002;89(3-4):293-301.
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2002: Hall Matthew D; Failes Timothy W; Hibbs David E; Hambley Trevor W
Structural investigations of palladium(II) and platinum(II) complexes of salicylhydroxamic acid.
Inorganic chemistry 2002;41(5):1223-8.
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2002: Dolman Rachael C; Deacon Glen B; Hambley Trevor W
Studies of the binding of a series of platinum(IV) complexes to plasma proteins.
Journal of inorganic biochemistry 2002;88(3-4):260-7.
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2001: Headlam H A; Weeks C L; Turner P; Hambley T W; Lay P A
Dinuclear chromium(V) amino acid complexes from the reduction of chromium(VI) in the presence of amino acid ligands: XAFS characterization of a chromium(V) amino acid complex.
Inorganic chemistry 2001;40(20):5097-105.
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2001: Hambley T W; Ling E C; Munk V P; Davies M S
Steric control of stereoselective interactions between the platinum(II) complex [PtCl2(1,4-diazacycloheptane)] and DNA: comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA binding and molecular modeling studies.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(5-6):534-42.
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2001: Davies M S; Diakos C I; Messerle B A; Hambley T W
Structure, stability, and interconversion barriers of the rotamers of cis-[Pt(II)Cl(2)(quinoline)2] and cis-[Pt(II)Cl(2)(3-bromoquinoline)(quinoline)] from X-ray crystallography, NMR spectroscopy and molecular mechanics evidence.
Inorganic chemistry 2001;40(13):3048-54.
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2001: Weder J E; Hambley T W; Kennedy B J; Lay P A; Foran G J; Rich A M
Determination of the structures of antiinflammatory copper(II) dimers of indomethacin by multiple-scattering analyses of X-ray absorption fine structure data.
Inorganic chemistry 2001;40(6):1295-302.
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2001: Platts J A; Hibbs D E; Hambley T W; Hall M D
Calculation of the hydrophobicity of platinum drugs.
Journal of medicinal chemistry 2001;44(3):472-4.
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2000: Davies M S; Berners-Price S J; Hambley T W
Slowing of cisplatin aquation in the presence of DNA but not in the presence of phosphate: improved understanding of sequence selectivity and the roles of monoaquated and diaquated species in the binding of cisplatin to DNA.
Inorganic chemistry 2000;39(25):5603-13.
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2000: Hambley T W; Ling E C; O'Mara S; McKeage M J; Russell P J
Increased targeting of adenine-rich sequences by (2-amino-2-methyl-3-butanone oxime)dichloroplatinum(II) and investigations into its low cytotoxicity.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(6):675-81.
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2000: Zhou Q; Hambley T W; Kennedy B J; Lay P A; Turner P; Warwick B; Biffin J R; Regtop H L
Syntheses and characterization of anti-inflammatory dinuclear and mononuclear zinc indomethacin complexes. Crystal structures of [Zn2(indomethacin)4(L)2] (L = N,N-dimethylacetamide, pyridine, 1-methyl-2-pyrrolidinone) and [Zn(indomethacin)2(L1)2] (L1 = ethanol, methanol).
Inorganic chemistry 2000;39(17):3742-8.
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2000: Davies M S; Berners-Price S J; Hambley T W
Rates of platination of -AG- and -GA- containing double-stranded oligonucleotides: effect of chloride concentration.
Journal of inorganic biochemistry 2000;79(1-4):167-72.
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2000: Codd R; Levina A; Zhang L; Hambley T W; Lay P A
Characterization and X-ray absorption spectroscopic studies of bis[quinato(2-)]oxochromate(V).
Inorganic chemistry 2000;39(5):990-7.
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2000: Screnci D; McKeage M J; Galettis P; Hambley T W; Palmer B D; Baguley B C
Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs.
British journal of cancer 2000;82(4):966-72.
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2000: Ling E C; Allen G W; Vickery K; Hambley T W
The preparation, characterisation, and DNA adduct profile of 2-amino-2-methyl-3-butanoneoximedichloroplatinum(II), a platinum(II) complex designed to bind to GpA sequences of DNA.
Journal of inorganic biochemistry 2000;78(1):55-62.
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1999: Hambley T W; Battle A R; Deacon G B; Lawrenz E T; Fallon G D; Gatehouse B M; Webster L K; Rainone S
Modifying the properties of platinum (IV) complexes in order to increase biological effectiveness.
Journal of inorganic biochemistry 1999;77(1-2):3-12.
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1998: Hambley T W; Berners-Price S J; Davies M S; Diakos C I; Er H M; Fenton R R; Ling E C; Rezler E M
Steric Determinants of Pt/DNA Interactions and Anticancer Activity.
Metal-based drugs 1998;5(4):197-206.
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1997: Reeder F; Guo Z; Murdoch P D; Corazza A; Hambley T W; Berners-Price S J; Chottard J C; Sadler P J
Platination of a GG site on single-stranded and double-stranded forms of a 14-base oligonucleotide with diaqua cisplatin followed by NMR and HPLC -- influence of the platinum ligands and base sequence on 5'-G versus 3'-G platination selectivity.
European journal of biochemistry / FEBS 1997;249(2):370-82.
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1997: Rezler E M; Fenton R R; Esdale W J; McKeage M J; Russell P J; Hambley T W
Preparation, characterization, DNA binding, and in vitro cytotoxicity of the enantiomers of the platinum(II) complexes N-methyl-, N-ethyl- and N,N-dimethyl-(R)- and -(S)-3-aminohexahydroazepinedichloroplatinum(II).
Journal of medicinal chemistry 1997;40(22):3508-15.
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1997: Fenton R R; Easdale W J; Er H M; O'Mara S M; McKeage M J; Russell P J; Hambley T W
Preparation, DNA binding, and in vitro cytotoxicity of a pair of enantiomeric platinum(II) complexes, [(R)- and (S)-3-aminohexahydroazepine]dichloroplatinum(II). Crystal structure of the S enantiomer.
Journal of medicinal chemistry 1997;40(7):1090-8.
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1997: Screnci D; Er H M; Hambley T W; Galettis P; Brouwer W; McKeage M J
Stereoselective peripheral sensory neurotoxicity of diaminocyclohexane platinum enantiomers related to ormaplatin and oxaliplatin.
British journal of cancer 1997;76(4):502-10.
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1995: Christopherson R I; Williams N K; Schoettle S L; Szabados E; Hambley T W; Manthey M K
Inhibitors of dihydro-orotase, amidophosphoribosyltransferase and IMP cyclohydrolase as potential drugs.
Biochemical Society transactions 1995;23(4):888-93.
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1995: Williams N K; Manthey M K; Hambley T W; O'Donoghue S I; Keegan M; Chapman B E; Christopherson R I
Catalysis by hamster dihydroorotase: zinc binding, site-directed mutagenesis, and interaction with inhibitors.
Biochemistry 1995;34(36):11344-52.
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1995: Kuke R K; Allan R D; Johnston G A; Mewett K N; Mitrovic A D; Duke C C; Hambley T W
Idiospermuline, a trimeric pyrrolidinoindoline alkaloid from the seed of Idiospermum australiense.
Journal of natural products 1995;58(8):1200-8.
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1994: Hambley T W; Webster L K
The preparation and in vivo activity of L- and D-O-methyl-methioninedichloroplatinum(II). The crystal structure of the L-enantiomer.
Journal of inorganic biochemistry 1994;55(3):175-81.
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1993: Vickery K; Bonin A M; Fenton R R; O'Mara S; Russell P J; Webster L K; Hambley T W
Preparation, characterization, cytotoxicity, and mutagenicity of a pair of enantiomeric platinum(II) complexes with the potential to bind enantioselectively to DNA.
Journal of medicinal chemistry 1993;36(23):3663-8.
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1991: Duke C C; Hambley T W; Holder G M; Navascues C O; Roberts-Thomson S; Ye Y R
Stereochemistry of the major rat liver microsomal metabolites of the carcinogen 7-methylbenz[c]acridine.
Chemical research in toxicology 1991;4(5):546-55.
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1990: Allan R D; Hanrahan J R; Hambley T W; Johnston G A; Mewett K N; Mitrovic A D
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids.
Journal of medicinal chemistry 1990;33(10):2905-15.
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1988: Hambley T W
Modelling the interaction of cisplatin with DNA.
Drug design and delivery 1988;3(2):153-8.
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