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Andrew Hamilton

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Cultured Tumor Cells

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Publications

TOP 3
Wang Yang; Hong Lei; Tapriyal Deepak; Kim In Chul; Paik Ik-Hyeon; Crosthwaite Jacob M; Hamilton Andrew D; Thies Mark C; Beckman Eric J; Enick Robert M; Johnson J Karl
Design and evaluation of nonfluorous CO2-soluble oligomers and polymers.
Hebda James A; Saraogi Ishu; Magzoub Mazin; Hamilton Andrew D; Miranker Andrew D
A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes.
Margulies David; Opatowsky Yarden; Fletcher Steven; Saraogi Ishu; Tsou Lun K; Saha Sourav; Lax Irit; Schlessinger Joseph; Hamilton Andrew D
Surface binding inhibitors of the SCF-KIT protein-protein interaction.

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All Publications

2009: Wang Yang; Hong Lei; Tapriyal Deepak; Kim In Chul; Paik Ik-Hyeon; Crosthwaite Jacob M; Hamilton Andrew D; Thies Mark C; Beckman Eric J; Enick Robert M; Johnson J Karl
Design and evaluation of nonfluorous CO2-soluble oligomers and polymers.
The journal of physical chemistry. B 2009;113(45):14971-80.
2009: Hebda James A; Saraogi Ishu; Magzoub Mazin; Hamilton Andrew D; Miranker Andrew D
A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes.
Chemistry & biology 2009;16(9):943-50.
2009: Margulies David; Opatowsky Yarden; Fletcher Steven; Saraogi Ishu; Tsou Lun K; Saha Sourav; Lax Irit; Schlessinger Joseph; Hamilton Andrew D
Surface binding inhibitors of the SCF-KIT protein-protein interaction.
Chembiochem : a European journal of chemical biology 2009;10(12):1955-8.
2009: Margulies David; Hamilton Andrew D
Digital analysis of protein properties by an ensemble of DNA quadruplexes.
Journal of the American Chemical Society 2009;131(26):9142-3.
2009: Saraogi Ishu; Hamilton Andrew D
Recent advances in the development of aryl-based foldamers.
Chemical Society reviews 2009;38(6):1726-43.
2009: Suryadevara Praveen Kumar; Olepu Srinivas; Lockman Jeffrey W; Ohkanda Junko; Karimi Mandana; Verlinde Christophe L M J; Kraus James M; Schoepe Jan; Van Voorhis Wesley C; Hamilton Andrew D; Buckner Frederick S; Gelb Michael H
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
Journal of medicinal chemistry 2009;52(12):3703-15.
2009: Rodriguez Johanna M; Ross Nathan T; Katt William P; Dhar Deepali; Lee Gui-In; Hamilton Andrew D
Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface.
ChemMedChem 2009;4(4):649-56.
2009: Wyrembak Pauline N; Hamilton Andrew D
Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics.
Journal of the American Chemical Society 2009;131(13):4566-7.
2009: Rosenzweig Brooke A; Ross Nathan T; Tagore Debarati M; Jayawickramarajah Janarthanan; Saraogi Ishu; Hamilton Andrew D
Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold.
Journal of the American Chemical Society 2009;131(14):5020-1.
2009: Rodriguez Johanna M; Nevola Laura; Ross Nathan T; Lee Gui-in; Hamilton Andrew D
Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold.
Chembiochem : a European journal of chemical biology 2009;10(5):829-33.
2009: Kayser-Bricker Katherine J; Glenn Matthew P; Lee Sang Hoon; Sebti Said M; Cheng Jin Q; Hamilton Andrew D
Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.
Bioorganic & medicinal chemistry 2009;17(4):1764-71.
2009: Cai Jianfeng; Shapiro Erik M; Hamilton Andrew D
Self-assembling DNA quadruplex conjugated to MRI contrast agents.
Bioconjugate chemistry 2009;20(2):205-8.
2009: Cummings Christopher G; Ross Nathan T; Katt William P; Hamilton Andrew D
Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic.
Organic letters 2009;11(1):25-8.
2009: Rosenzweig Brooke A; Hamilton Andrew D
Self-assembly of a four-helix bundle on a DNA quadruplex.
Angewandte Chemie (International ed. in English) 2009;48(15):2749-51.
2009: Margulies David; Hamilton Andrew D
Protein recognition by an ensemble of fluorescent DNA G-quadruplexes.
Angewandte Chemie (International ed. in English) 2009;48(10):1771-4.
2009: Cai Jianfeng; Rosenzweig Brooke A; Hamilton Andrew D
Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(2):328-32.
2008: Saraogi Ishu; Hamilton Andrew D
alpha-Helix mimetics as inhibitors of protein-protein interactions.
Biochemical Society transactions 2008;36(Pt 6):1414-7.
2008: Gunning Patrick T; Glenn Matthew P; Siddiquee Khandaker A Z; Katt William P; Masson Eric; Sebti Saïd M; Turkson James; Hamilton Andrew D
Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders.
Chembiochem : a European journal of chemical biology 2008;9(17):2800-3.
2008: Fletcher Steven; Cummings Christopher G; Rivas Kasey; Katt William P; Hornéy Carrie; Buckner Frederick S; Chakrabarti Debopam; Sebti Saïd M; Gelb Michael H; Van Voorhis Wesley C; Hamilton Andrew D
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Journal of medicinal chemistry 2008;51(17):5176-97.
2008: Saraogi Ishu; Incarvito Christopher D; Hamilton Andrew D
Controlling curvature in a family of oligoamide alpha-helix mimetics.
Angewandte Chemie (International ed. in English) 2008;47(50):9691-4.
2007: Siddiquee Khandaker A Z; Gunning Patrick T; Glenn Matthew; Katt William P; Zhang Shumin; Schrock Christopher; Sebti Said M; Jove Richard; Hamilton Andrew D; Turkson James
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.
ACS chemical biology 2007;2(12):787-98.
2007: Van Voorhis Wesley C; Rivas Kasey L; Bendale Pravin; Nallan Laxman; Hornéy Carolyn; Barrett Lynn K; Bauer Kevin D; Smart Brian P; Ankala Sudha; Hucke Oliver; Verlinde Christophe L M J; Chakrabarti Debopam; Strickland Corey; Yokoyama Kohei; Buckner Frederick S; Hamilton Andrew D; Williams David K; Lombardo Louis J; Floyd David; Gelb Michael H
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Antimicrobial agents and chemotherapy 2007;51(10):3659-71.
2007: Park Kwanghee Koh; Park Joon Woo; Hamilton Andrew D
Solvent and pH effects on the fluorescence of 7-(dimethylamino)-2-fluorenesulfonate.
Journal of fluorescence 2007;17(4):361-9.
2007: Gunning Patrick T; Katt William P; Glenn Matthew; Siddiquee Khandaker; Kim Joon S; Jove Richard; Sebti Saïd M; Turkson James; Hamilton Andrew D
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.
Bioorganic & medicinal chemistry letters 2007;17(7):1875-8.
2007: Kayser Katherine J; Glenn Matthew P; Sebti Said M; Cheng Jin Q; Hamilton Andrew D
Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.
Bioorganic & medicinal chemistry letters 2007;17(7):2068-73.
2007: Stern Eric; Klemic James F; Routenberg David A; Wyrembak Pauline N; Turner-Evans Daniel B; Hamilton Andrew D; LaVan David A; Fahmy Tarek M; Reed Mark A
Label-free immunodetection with CMOS-compatible semiconducting nanowires.
Nature 2007;445(7127):519-22.
2007: Davis Jessica M; Tsou Lun K; Hamilton Andrew D
Synthetic non-peptide mimetics of alpha-helices.
Chemical Society reviews 2007;36(2):326-34.
2007: Delarue F L; Adnane J; Joshi B; Blaskovich M A; Wang D-A; Hawker J; Bizouarn F; Ohkanda J; Zhu K; Hamilton A D; Chellappan S; Sebti S M
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Oncogene 2007;26(5):633-40.
2007: Wilson Andrew J; Hong Jason; Fletcher Steven; Hamilton Andrew D
Recognition of solvent exposed protein surfaces using anthracene derived receptors.
Organic & biomolecular chemistry 2007;5(2):276-85.
2007: Rodriguez Johanna M; Hamilton Andrew D
Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices.
Angewandte Chemie (International ed. in English) 2007;46(45):8614-7.
2007: Jayawickramarajah Janarthanan; Tagore Debarati M; Tsou Lun K; Hamilton Andrew D
Allosteric control of self-assembly: modulating the formation of guanine quadruplexes through orthogonal aromatic interactions.
Angewandte Chemie (International ed. in English) 2007;46(40):7583-6.
2007: Fletcher Steven; Hamilton Andrew D
Protein-protein interaction inhibitors: small molecules from screening techniques.
Current topics in medicinal chemistry 2007;7(10):922-7.
2007: Becerril Jorge; Hamilton Andrew D
Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides.
Angewandte Chemie (International ed. in English) 2007;46(24):4471-3.
2007: Paik Ik-Hyeon; Tapriyal Deepak; Enick Robert M; Hamilton Andrew D
Fiber formation by highly CO2-soluble bisureas containing peracetylated carbohydrate groups.
Angewandte Chemie (International ed. in English) 2007;46(18):3284-7.
2007: Tagore Debarati M; Sprinz K Ingrid; Fletcher Steven; Jayawickramarajah Janarthanan; Hamilton Andrew D
Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold.
Angewandte Chemie (International ed. in English) 2007;46(1-2):223-5.
2006: Kim Joseph T; Hamilton Andrew D; Bailey Christopher M; Domaoal Robert A; Wang Ligong; Anderson Karen S; Jorgensen William L
FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of the American Chemical Society 2006;128(48):15372-3.
2006: Thakur Vinay V; Kim Joseph T; Hamilton Andrew D; Bailey Christopher M; Domaoal Robert A; Wang Ligong; Anderson Karen S; Jorgensen William L
Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2006;16(21):5664-7.
2006: Anagnostopoulou Aikaterini; Vultur Adina; Arulanandam Rozanne; Cao Jun; Turkson James; Jove Richard; Kim Joon S; Glenn Matthew; Hamilton Andrew D; Raptis Leda
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.
Cancer letters 2006;242(1):120-32.
2006: Glenn Matthew P; Chang Sung-Youn; Hornéy Carrie; Rivas Kasey; Yokoyama Kohei; Pusateri Erin E; Fletcher Steven; Cummings Christopher G; Buckner Frederick S; Pendyala Prakash R; Chakrabarti Debopam; Sebti Saïd M; Gelb Michael; Van Voorhis Wesley C; Hamilton Andrew D
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Journal of medicinal chemistry 2006;49(19):5710-27.
2006: Zhou Huchen; Wang De-an; Baldini Laura; Ennis Eileen; Jain Rishi; Carie Adam; Sebti Saïd M; Hamilton Andrew D
Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.
Organic & biomolecular chemistry 2006;4(12):2376-86.
2006: Peng Hairuo; Carrico Dora; Thai Van; Blaskovich Michelle; Bucher Cynthia; Pusateri Erin E; Sebti Said M; Hamilton Andrew D
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
Organic & biomolecular chemistry 2006;4(9):1768-84.
2006: Fletcher Steven; Hamilton Andrew D
Targeting protein-protein interactions by rational design: mimicry of protein surfaces.
Journal of the Royal Society, Interface / the Royal Society 2006;3(7):215-33.
2006: Kim In Chul; Hamilton Andrew D
Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix.
Organic letters 2006;8(9):1751-4.
2006: Zhou Huchen; Baldini Laura; Hong Jason; Wilson Andrew J; Hamilton Andrew D
Pattern recognition of proteins based on an array of functionalized porphyrins.
Journal of the American Chemical Society 2006;128(7):2421-5.
2006: Ohkanda Junko; Strickland Corey L; Blaskovich Michelle A; Carrico Dora; Lockman Jeffrey W; Vogt Andreas; Bucher Cynthia J; Sun Jiazhi; Qian Yimin; Knowles David; Pusateri Erin E; Sebti Saïd M; Hamilton Andrew D
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Organic & biomolecular chemistry 2006;4(3):482-92.
2006: Ruiz-Caro Juliana; Basavapathruni Aravind; Kim Joseph T; Bailey Christopher M; Wang Ligong; Anderson Karen S; Hamilton Andrew D; Jorgensen William L
Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2006;16(3):668-71.
2006: Jorgensen William L; Ruiz-Caro Juliana; Tirado-Rives Julian; Basavapathruni Aravind; Anderson Karen S; Hamilton Andrew D
Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2006;16(3):663-7.
2005: Guida Wayne C; Hamilton Andrew D; Crotty Justin W; Sebti Saïd M
Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling.
Journal of computer-aided molecular design 2005;19(12):871-85.
2005: Davis Jessica M; Truong Anh; Hamilton Andrew D
Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic.
Organic letters 2005;7(24):5405-8.
2005: Sprinz K Ingrid; Tagore Debarati M; Hamilton Andrew D
Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments.
Bioorganic & medicinal chemistry letters 2005;15(17):3908-11.
2005: Fan Xin; Potluri Vijay K; McLeod M Chandler; Wang Yang; Liu Juncheng; Enick Robert M; Hamilton Andrew D; Roberts Christopher B; Johnson J Karl; Beckman Eric J
Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility.
Journal of the American Chemical Society 2005;127(33):11754-62.
2005: Glenn Matthew P; Chang Sung-Youn; Hucke Oliver; Verlinde Christophe L M J; Rivas Kasey; Hornéy Carrie; Yokoyama Kohei; Buckner Frederick S; Pendyala Prakash R; Chakrabarti Debopam; Gelb Michael; Van Voorhis Wesley C; Sebti Saïd M; Hamilton Andrew D
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angewandte Chemie (International ed. in English) 2005;44(31):4903-6.
2005: Yin Hang; Lee Gui-In; Sedey Kristine A; Kutzki Olaf; Park Hyung Soon; Orner Brendan P; Ernst Justin T; Wang Hong-Gang; Sebti Said M; Hamilton Andrew D
Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.
Journal of the American Chemical Society 2005;127(29):10191-6.
2005: Yin Hang; Hamilton Andrew D
Strategies for targeting protein-protein interactions with synthetic agents.
Angewandte Chemie (International ed. in English) 2005;44(27):4130-63.
2005: Sun Jiazhi; Wang De-An; Jain Rishi K; Carie Adam; Paquette Steve; Ennis Eileen; Blaskovich Michelle A; Baldini Laura; Coppola Domenico; Hamilton Andrew D; Sebti Saïd M
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.
Oncogene 2005;24(29):4701-9.
2005: Yin Hang; Lee Gui-In; Sedey Kristine A; Rodriguez Johanna M; Wang Hong-Gang; Sebti Said M; Hamilton Andrew D
Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction.
Journal of the American Chemical Society 2005;127(15):5463-8.
2005: Yin Hang; Lee Gui-in; Park Hyung Soon; Payne Gregory A; Rodriguez Johanna M; Sebti Said M; Hamilton Andrew D
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.
Angewandte Chemie (International ed. in English) 2005;44(18):2704-7.
2005: Carrico Dora; Blaskovich Michelle A; Bucher Cynthia J; Sebti Saïd M; Hamilton Andrew D
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
Bioorganic & medicinal chemistry 2005;13(3):677-88.
2005: Magliery Thomas J; Wilson Christopher G M; Pan Weilan; Mishler Dennis; Ghosh Indraneel; Hamilton Andrew D; Regan Lynne
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism.
Journal of the American Chemical Society 2005;127(1):146-57.
2005: Lockman Jeffrey W; Hamilton Andrew D
Recent developments in the identification of chemotherapeutics for Chagas disease.
Current medicinal chemistry 2005;12(8):945-59.
2004: Carrico Dora; Ohkanda Junko; Kendrick Howard; Yokoyama Kohei; Blaskovich Michelle A; Bucher Cynthia J; Buckner Frederick S; Van Voorhis Wesley C; Chakrabarti Debopam; Croft Simon L; Gelb Michael H; Sebti Saïd M; Hamilton Andrew D
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
2004: Groves Kevin; Wilson Andrew J; Hamilton Andrew D
Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents.
Journal of the American Chemical Society 2004;126(40):12833-42.
2004: Sun Jiazhi; Blaskovich Michelle A; Jain Rishi K; Delarue Frederic; Paris Daniel; Brem Steven; Wotoczek-Obadia Marguerite; Lin Qing; Coppola Domenico; Choi Kihang; Mullan Michael; Hamilton Andrew D; Sebti Saïd M
Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.
Cancer research 2004;64(10):3586-92.
2004: Baldini Laura; Wilson Andrew J; Hong Jason; Hamilton Andrew D
Pattern-based detection of different proteins using an array of fluorescent protein surface receptors.
Journal of the American Chemical Society 2004;126(18):5656-7.
2004: Turkson James; Kim Joon S; Zhang Shumin; Yuan Jing; Huang Mei; Glenn Matthew; Haura Eric; Sebti Said; Hamilton Andrew D; Jove Richard
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.
Molecular cancer therapeutics 2004;3(3):261-9.
2004: Estroff Lara A; Hamilton Andrew D
Water gelation by small organic molecules.
Chemical reviews 2004;104(3):1201-18.
2004: Yin Hang; Hamilton Andrew D
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein.
Bioorganic & medicinal chemistry letters 2004;14(6):1375-9.
2004: Estroff Lara A; Addadi Lia; Weiner Steve; Hamilton Andrew D
An organic hydrogel as a matrix for the growth of calcite crystals.
Organic & biomolecular chemistry 2004;2(1):137-41.
2004: Ohkanda Junko; Buckner Frederick S; Lockman Jeffrey W; Yokoyama Kohei; Carrico Dora; Eastman Richard; de Luca-Fradley Kate; Davies Wendy; Croft Simon L; Van Voorhis Wesley C; Gelb Michael H; Sebti Saïd M; Hamilton Andrew D
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2004: Estroff Lara A; Incarvito Christopher D; Hamilton Andrew D
Design of a synthetic foldamer that modifies the growth of calcite crystals.
Journal of the American Chemical Society 2004;126(1):2-3.
2004: Salvatella Xavier; Martinell Marc; Gairí Margarida; Mateu Mauricio G; Feliz Miguel; Hamilton Andrew D; De Mendoza Javier; Giralt Ernest
A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53.
Angewandte Chemie (International ed. in English) 2004;43(2):196-8.
2004: Jain Rishi; Ernst Justin T; Kutzki Olaf; Park Hyung Soon; Hamilton Andrew D
Protein recognition using synthetic surface-targeted agents.
Molecular diversity 2004;8(2):89-100.
2003: Zhu Kuichun; Hamilton Andrew D; Sebti Saïd M
Farnesyltransferase inhibitors as anticancer agents: current status.
Current opinion in investigational drugs (London, England : 2000) 2003;4(12):1428-35.
2003: Estroff Lara A; Huang Jessica S; Hamilton Andrew D
Fiber formation in water by a mono-urea dicarboxylic acid.
Chemical communications (Cambridge, England) 2003;(24):2958-9.
2003: Sun Jiazhi; Ohkanda Junko; Coppola Domenico; Yin Hang; Kothare Mohit; Busciglio Brian; Hamilton Andrew D; Sebti Saïd M
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Cancer research 2003;63(24):8922-9.
2003: Choi Kihang; Hamilton Andrew D
Rigid macrocyclic triamides as anion receptors: anion-dependent binding stoichiometries and 1H chemical shift changes.
Journal of the American Chemical Society 2003;125(34):10241-9.
2003: Bordier Bruno B; Ohkanda Junko; Liu Ping; Lee So-Young; Salazar F H; Marion Patricia L; Ohashi Kazuo; Meuse Leonard; Kay Mark A; Casey John L; Sebti Said M; Hamilton Andrew D; Glenn Jeffrey S
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
The Journal of clinical investigation 2003;112(3):407-14.
2003: Aya Toshihiro; Hamilton Andrew D
Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding.
Bioorganic & medicinal chemistry letters 2003;13(16):2651-4.
2003: Wilson Andrew J; Groves Kevin; Jain Rishi K; Park Hyung Soon; Hamilton Andrew D
Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer.
Journal of the American Chemical Society 2003;125(15):4420-1.
2003: Wang Guijun; Hamilton Andrew D
Low molecular weight organogelators for water.
Chemical communications (Cambridge, England) 2003;(3):310-1.
2003: Ernst Justin T; Becerril Jorge; Park Hyung Soon; Yin Hang; Hamilton Andrew D
Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex.
Angewandte Chemie (International ed. in English) 2003;42(5):535-9.
2003: Ohkanda Junko; Blaskovich Michelle A; Sebti Saïd M; Hamilton Andrew D
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.
Progress in cell cycle research 2003;5():211-7.
2002: Allal Cuider; Pradines Anne; Hamilton Andrew D; Sebti Said M; Favre Gilles
Farnesylated RhoB prevents cell cycle arrest and actin cytoskeleton disruption caused by the geranylgeranyltransferase I inhibitor GGTI-298.
Cell cycle (Georgetown, Tex.) 2002;1(6):430-7.
2002: Kutzki Olaf; Park Hyung Soon; Ernst Justin T; Orner Brendan P; Yin Hang; Hamilton Andrew D
Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry.
Journal of the American Chemical Society 2002;124(40):11838-9.
2002: Zhao Qian; Ernst Justin T; Hamilton Andrew D; Debnath Asim K; Jiang Shibo
XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41.
AIDS research and human retroviruses 2002;18(14):989-97.
2002: Potluri Vijay K; Xu Jianhang; Enick Robert; Beckman Eric; Hamilton Andrew D
Peracetylated sugar derivatives show high solubility in liquid and supercritical carbon dioxide.
Organic letters 2002;4(14):2333-5.
2002: Crespo N C; Delarue F; Ohkanda J; Carrico D; Hamilton A D; Sebti S M
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.
Cell death and differentiation 2002;9(7):702-9.
2002: Li Xianwu; Liu Li; Tupper Joan C; Bannerman Douglas D; Winn Robert K; Sebti Said M; Hamilton Andrew D; Harlan John M
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
The Journal of biological chemistry 2002;277(18):15309-16.
2002: Wang Guijun; Hamilton Andrew D
Synthesis and self-assembling properties of polymerizable organogelators.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(8):1954-61.
2002: Park Hyung Soon; Lin Qing; Hamilton Andrew D
Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5105-9.
2002: Ohkanda Junko; Knowles David B; Blaskovich Michelle A; Sebti Said M; Hamilton Andrew D
Inhibitors of protein farnesyltransferase as novel anticancer agents.
Current topics in medicinal chemistry 2002;2(3):303-23.
2002: Orner Brendan P; Salvatella Xavier; Sánchez Quesada Jorge; De Mendoza Javier; Giralt Ernest; Hamilton Andrew D
De novo protein surface design: use of cation-pi interactions to enhance binding between an alpha-helical peptide and a cationic molecule in 50 % aqueous solution.
Angewandte Chemie (International ed. in English) 2002;41(1):117-9.
2002: Ernst Justin T; Kutzki Olaf; Debnath Asim K; Jiang Shibo; Lu Hong; Hamilton Andrew D
Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion.
Angewandte Chemie (International ed. in English) 2002;41(2):278-81.
2002: Ohkanda Junko; Lockman Jeffrey W; Kothare Mohit A; Qian Yimin; Blaskovich Michelle A; Sebti Said M; Hamilton Andrew D
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Journal of medicinal chemistry 2002;45(1):177-88.
2001: Linton B R; Goodman M S; Fan E; van Arman S A; Hamilton A D
Thermodynamic aspects of dicarboxylate recognition by simple artificial receptors.
The Journal of organic chemistry 2001;66(22):7313-9.
2001: Kucich U; Rosenbloom J C; Herrick D J; Abrams W R; Hamilton A D; Sebti S M; Rosenbloom J
Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts.
Archives of biochemistry and biophysics 2001;395(1):103-12.
2001: Turkson J; Ryan D; Kim J S; Zhang Y; Chen Z; Haura E; Laudano A; Sebti S; Hamilton A D; Jove R
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.
The Journal of biological chemistry 2001;276(48):45443-55.
2001: Hamuro Y; Hamilton A D
Functionalized oligoanthranilamides: modular and conformationally controlled scaffolds.
Bioorganic & medicinal chemistry 2001;9(9):2355-63.
2001: Orner B P; Ernst J T; Hamilton A D
Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix.
Journal of the American Chemical Society 2001;123(22):5382-3.
2001: Crespo N C; Ohkanda J; Yen T J; Hamilton A D; Sebti S M
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.
The Journal of biological chemistry 2001;276(19):16161-7.
2001: Choi K; Hamilton A D
Selective anion binding by a macrocycle with convergent hydrogen bonding functionality.
Journal of the American Chemical Society 2001;123(10):2456-7.
2001: Ohkanda J; Lockman J W; Yokoyama K; Gelb M H; Croft S L; Kendrick H; Harrell M I; Feagin J E; Blaskovich M A; Sebti S M; Hamilton A D
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.
2001: Sun J; Nam S; Lee C S; Li B; Coppola D; Hamilton A D; Dou Q P; Sebti S M
CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice.
Cancer research 2001;61(4):1280-4.
2000: Sebti S M; Hamilton A D
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.
Expert opinion on investigational drugs 2000;9(12):2767-82.
2000: Adnane J; Bizouarn F A; Chen Z; Ohkanda J; Hamilton A D; Munoz-Antonia T; Sebti S M
Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.
Oncogene 2000;19(48):5525-33.
2000: Wei S; Gilvary D L; Corliss B C; Sebti S; Sun J; Straus D B; Leibson P J; Trapani J A; Hamilton A D; Weber M J; Djeu J Y
Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3811-9.
2000: Blaskovich M A; Lin Q; Delarue F L; Sun J; Park H S; Coppola D; Hamilton A D; Sebti S M
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.
Nature biotechnology 2000;18(10):1065-70.
2000: Allal C; Favre G; Couderc B; Salicio S; Sixou S; Hamilton A D; Sebti S M; Lajoie-Mazenc I; Pradines A
RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.
The Journal of biological chemistry 2000;275(40):31001-8.
2000: Cohen-Jonathan E; Muschel R J; Gillies McKenna W; Evans S M; Cerniglia G; Mick R; Kusewitt D; Sebti S M; Hamilton A D; Oliff A; Kohl N; Gibbs J B; Bernhard E J
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
Radiation research 2000;154(2):125-32.
2000: Linton B R; Goodman M S; Hamilton A D
Nitronate anion recognition and modulation of ambident reactivity by hydrogen-bonding receptors.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(13):2449-55.
2000: Rosenbloom J; Saitta B; Gaidarova S; Sandorfi N; Rosenbloom J C; Abrams W R; Hamilton A D; Sebti S M; Kucich U; Jimenez S A
Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I.
Arthritis and rheumatism 2000;43(7):1624-32.
2000: Jain R K; Hamilton A D
Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold.
Organic letters 2000;2(12):1721-3.
2000: Kucich U; Rosenbloom J C; Shen G; Abrams W R; Hamilton A D; Sebti S M; Rosenbloom J
TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2.
Archives of biochemistry and biophysics 2000;374(2):313-24.
2000: Sebti S M; Hamilton A D
Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors.
Methods in enzymology 2000;325():381-8.
1999: Qian Y; Marugan J J; Fossum R D; Vogt A; Sebti S M; Hamilton A D
Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.
Bioorganic & medicinal chemistry 1999;7(12):3011-24.
1999: Sun J; Blaskovich M A; Knowles D; Qian Y; Ohkanda J; Bailey R D; Hamilton A D; Sebti S M
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Cancer research 1999;59(19):4919-26.
1999: Cohen-Jonathan E; Toulas C; Ader I; Monteil S; Allal C; Bonnet J; Hamilton A D; Sebti S M; Daly-Schveitzer N; Favre G
The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS.
Radiation research 1999;152(4):404-11.
1999: Linton B; Hamilton A D
Host-guest chemistry: combinatorial receptors.
Current opinion in chemical biology 1999;3(3):307-12.
1999: Vasudevan A; Qian Y; Vogt A; Blaskovich M A; Ohkanda J; Sebti S M; Hamilton A D
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Journal of medicinal chemistry 1999;42(8):1333-40.
1999: Sun J; Qian Y; Chen Z; Marfurt J; Hamilton A D; Sebti S M
The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity.
The Journal of biological chemistry 1999;274(11):6930-4.
1998: Sharma T A; Carr A J; Davis R S; Reynolds I J; Hamilton A D
Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor.
Bioorganic & medicinal chemistry letters 1998;8(24):3459-64.
1998: Adnane J; Bizouarn F A; Qian Y; Hamilton A D; Sebti S M
p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.
Molecular and cellular biology 1998;18(12):6962-70.
1998: Kucich U; Rosenbloom J C; Shen G; Abrams W R; Blaskovich M A; Hamilton A D; Ohkanda J; Sebti S M; Rosenbloom J
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Biochemical and biophysical research communications 1998;252(1):111-6.
1998: Stark W W; Blaskovich M A; Johnson B A; Qian Y; Vasudevan A; Pitt B; Hamilton A D; Sebti S M; Davies P
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
The American journal of physiology 1998;275(1 Pt 1):L55-63.
1998: Bernhard E J; McKenna W G; Hamilton A D; Sebti S M; Qian Y; Wu J M; Muschel R J
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
Cancer research 1998;58(8):1754-61.
1998: Weiner W S; Hamilton A D
Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides.
Bioorganic & medicinal chemistry letters 1998;8(6):681-6.
1998: Qian Y; Vogt A; Vasudevan A; Sebti S M; Hamilton A D
Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics.
Bioorganic & medicinal chemistry 1998;6(3):293-9.
1998: Lin Q; Park H S; Hamuro Y; Lee C S; Hamilton A D
Protein surface recognition by synthetic agents: design and structural requirements of a family of artificial receptors that bind to cytochrome c.
Biopolymers 1998;47(4):285-97.
1997: Chen H; Weiner W S; Hamilton A D
Recognition of neutral species with synthetic receptors.
Current opinion in chemical biology 1997;1(4):458-66.
1997: Sebti S M; Hamilton A D
Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development.
Expert opinion on investigational drugs 1997;6(11):1711-4.
1997: Sebti S; Hamilton A D
Inhibitors of prenyl transferases.
Current opinion in oncology 1997;9(6):557-61.
1997: Vogt A; Sun J; Qian Y; Hamilton A D; Sebti S M
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
The Journal of biological chemistry 1997;272(43):27224-9.
1997: Lerner E C; Zhang T T; Knowles D B; Qian Y; Hamilton A D; Sebti S M
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Oncogene 1997;15(11):1283-8.
1997: Albert J S; Peczuh M W; Hamilton A D
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an alpha-helical conformation.
Bioorganic & medicinal chemistry 1997;5(8):1455-67.
1997: Lerner E C; Hamilton A D; Sebti S M
Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design.
Anti-cancer drug design 1997;12(4):229-38.
1997: Miquel K; Pradines A; Sun J; Qian Y; Hamilton A D; Sebti S M; Favre G
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
Cancer research 1997;57(10):1846-50.
1997: Finder J D; Litz J L; Blaskovich M A; McGuire T F; Qian Y; Hamilton A D; Davies P; Sebti S M
Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
The Journal of biological chemistry 1997;272(21):13484-8.
1997: Sebti S M; Hamilton A D
Inhibition of Ras prenylation: a novel approach to cancer chemotherapy.
Pharmacology & therapeutics 1997;74(1):103-14.
1997: Qian Y; Sebti S M; Hamilton A D
Farnesyltransferase as a target for anticancer drug design.
Biopolymers 1997;43(1):25-41.
1996: Vogt A; Qian Y; McGuire T F; Hamilton A D; Sebti S M
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Oncogene 1996;13(9):1991-9.
1996: McGuire T F; Qian Y; Vogt A; Hamilton A D; Sebti S M
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
The Journal of biological chemistry 1996;271(44):27402-7.
1996: Sebti S M; Hamilton A D
Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs.
Biochemical Society transactions 1996;24(3):692-9.
1996: Hopkins R B; Albert J S; Van Engen D; Hamilton A D
Synthesis and structure of chiral macrocycles containing 2,2'-bipyridine subunits.
Bioorganic & medicinal chemistry 1996;4(7):1121-8.
1996: Bernhard E J; Kao G; Cox A D; Sebti S M; Hamilton A D; Muschel R J; McKenna W G
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.
Cancer research 1996;56(8):1727-30.
1996: Qian Y; Vogt A; Sebti S M; Hamilton A D
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.
Journal of medicinal chemistry 1996;39(1):217-23.
1995: Lerner E C; Qian Y; Blaskovich M A; Fossum R D; Vogt A; Sun J; Cox A D; Der C J; Hamilton A D; Sebti S M
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
The Journal of biological chemistry 1995;270(45):26802-6.
1995: Lerner E C; Qian Y; Hamilton A D; Sebti S M
Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
The Journal of biological chemistry 1995;270(45):26770-3.
1995: Kauffmann R C; Qian Y; Vogt A; Sebti S M; Hamilton A D; Carthew R W
Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10919-23.
1995: Sun J; Qian Y; Hamilton A D; Sebti S M
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
Cancer research 1995;55(19):4243-7.
1995: McGuire T F; Qian Y; Blaskovich M A; Fossum R D; Sun J; Marlowe T; Corey S J; Wathen S P; Vogt A; Hamilton A D
CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.
Biochemical and biophysical research communications 1995;214(1):295-303.
1995: Vogt A; Sun J; Qian Y; Tan-Chiu E; Hamilton A D; Sebti S M
Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.
Biochemistry 1995;34(38):12398-403.
1995: Albert J S; Hamilton A D
Stabilization of helical domains in short peptides using hydrophobic interactions.
Biochemistry 1995;34(3):984-90.
1995: Vogt A; Qian Y; Blaskovich M A; Fossum R D; Hamilton A D; Sebti S M
A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.
The Journal of biological chemistry 1995;270(2):660-4.
1994: Qian Y; Blaskovich M A; Saleem M; Seong C M; Wathen S P; Hamilton A D; Sebti S M
Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.
The Journal of biological chemistry 1994;269(17):12410-3.
1993: Nigam M; Seong C M; Qian Y; Hamilton A D; Sebti S M
Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.
The Journal of biological chemistry 1993;268(28):20695-8.

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