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Andrew Hamilton

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Charlotte L Sutherell; Sam Thompson; Richard T W Scott; Andrew D Hamilton
Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics.
Marc J Adler; Richard T W Scott; Andrew D Hamilton
Enaminone-based mimics of extended and hydrophilic α-helices.
Partha S Ghosh; Andrew D Hamilton
Noncovalent template-assisted mimicry of multiloop protein surfaces: assembling discontinuous and functional domains.

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All Publications

2012: Charlotte L Sutherell; Sam Thompson; Richard T W Scott; Andrew D Hamilton
Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics.
Chemical communications (Cambridge, England) 2012;48(79):9834-6.
2012: Marc J Adler; Richard T W Scott; Andrew D Hamilton
Enaminone-based mimics of extended and hydrophilic α-helices.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(41):12974-7.
2012: Partha S Ghosh; Andrew D Hamilton
Noncovalent template-assisted mimicry of multiloop protein surfaces: assembling discontinuous and functional domains.
Journal of the American Chemical Society 2012;134(32):13208-11.
2012: Sam Thompson; Andrew D Hamilton
Amphiphilic α-helix mimetics based on a benzoylurea scaffold.
Organic & biomolecular chemistry 2012;10(30):5780-2.
2012: Lun K Tsou; Chin-Ho Chen; Yung-Chi Cheng; Ginger E Dutschman; Andrew D Hamilton
Blocking HIV-1 entry by a gp120 surface binding inhibitor.
Bioorganic & medicinal chemistry letters 2012;22(9):3358-61.
2012: Partha S Ghosh; Andrew D Hamilton
Supramolecular dendrimers: convenient synthesis by programmed self-assembly and tunable thermoresponsivity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(8):2361-5.
2011: Marc J Adler; Andrew D Hamilton
Oligophenylenaminones as scaffolds for α-helix mimicry.
The Journal of organic chemistry 2011;76(17):7040-7.
2011: Ian M Jones; Andrew D Hamilton
Anion-dependent switching: dynamically controlling the conformation of hydrogen-bonded diphenylacetylenes.
Angewandte Chemie (International ed. in English) 2011;50(20):4597-600.
2011: Marc J Adler; Andrew G Jamieson; Andrew D Hamilton
Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.
Current topics in microbiology and immunology 2011;348():1-23.
2010: Stephen Fletcher; Erin Pusateri Keaney; Christopher G Cummings; Michelle A Blaskovich; Michael A Hast; Matthew Glenn; Sung-Youn Chang; Cynthia J Bucher; Ryan J Floyd; William P Katt; Michael H Gelb; Wesley C Van Voorhis; Lorena S Beese; Said M Sebti; Andrew D Hamilton
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Journal of medicinal chemistry 2010;53(19):6867-88.
2010: Ian M Jones; Andrew D Hamilton
Designed molecular switches: controlling the conformation of benzamido-diphenylacetylenes.
Organic letters 2010;12(16):3651-3.
2010: Christopher G Cummings; Andrew D Hamilton
Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.
Current opinion in chemical biology 2010;14(3):341-6.
2010: Brooke A Rosenzweig; Nathan T Ross; Marc J Adler; Andrew D Hamilton
Altered binding of a multimeric protein by changing the self-assembling properties of its substrate.
Journal of the American Chemical Society 2010;132(19):6749-54.
2010: Lun K Tsou; Ginger E Dutschman; Elizabeth Gullen; Maria Telpoukhovskaia; Yung-Chi Cheng; Andrew D Hamilton
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.
Bioorganic & medicinal chemistry letters 2010;20(7):2137-9.
2010: Sourav Saha; Jianfeng Cai; Daniel Eiler; Andrew D Hamilton
Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions.
Chemical communications (Cambridge, England) 2010;46(10):1685-7.
2010: Nathan T Ross; William P Katt; Andrew D Hamilton
Synthetic mimetics of protein secondary structure domains.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2010;368(1914):989-1008.
2010: Jianfeng Cai; Dariusz M Niedzwiedzki; Harry A Frank; Andrew D Hamilton
Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA quadruplex.
Chemical communications (Cambridge, England) 2010;46(4):544-6.
2010: Ishu Saraogi; James A Hebda; Jorge Becerril; Lara A Estroff; Andrew D Miranker; Andrew D Hamilton
Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation.
Angewandte Chemie (International ed. in English) 2010;49(4):736-9.
2010: Yao Cheng; Lun K Tsou; Jianfeng Cai; Toshihiro Aya; Ginger E Dutschman; Elizabeth Gullen; Susan P Grill; Annie Pei-Chun Chen; Brett D Lindenbach; Andrew D Hamilton; Yung-Chi Cheng
A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.
Antimicrobial agents and chemotherapy 2010;54(1):197-206.
2009: Yang Wang; Lei Hong; Deepak Tapriyal; In Chul Kim; Ik-Hyeon Paik; Jacob M Crosthwaite; Andrew D Hamilton; Mark C Thies; Eric J Beckman; Robert M Enick; J Karl Johnson
Design and evaluation of nonfluorous CO2-soluble oligomers and polymers.
The journal of physical chemistry. B 2009;113(45):14971-80.
2009: Sarah E Pierce; Junmei Wang; Janarthanan Jayawickramarajah; Andrew D Hamilton; Jennifer S Brodbelt
Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(42):11244-55.
2009: James A Hebda; Ishu Saraogi; Mazin Magzoub; Andrew D Hamilton; Andrew D Miranker
A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes.
Chemistry & biology 2009;16(9):943-50.
2009: David Margulies; Yarden Opatowsky; Stephen Fletcher; Ishu Saraogi; Lun K Tsou; Sourav Saha; Irit Lax; Joseph Schlessinger; Andrew D Hamilton
Surface binding inhibitors of the SCF-KIT protein-protein interaction.
Chembiochem : a European journal of chemical biology 2009;10(12):1955-8.
2009: David Margulies; Andrew D Hamilton
Digital analysis of protein properties by an ensemble of DNA quadruplexes.
Journal of the American Chemical Society 2009;131(26):9142-3.
2009: Praveen Kumar Suryadevara; Srinivas Olepu; Jeffrey W Lockman; Junko Ohkanda; Mandana Karimi; Christophe Verlinde; James M Kraus; Jan Schoepe; Wesley C Van Voorhis; Andrew D Hamilton; Frederick S Buckner; Michael H Gelb
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
Journal of medicinal chemistry 2009;52(12):3703-15.
2009: Ishu Saraogi; Andrew D Hamilton
Recent advances in the development of aryl-based foldamers.
Chemical Society reviews 2009;38(6):1726-43.
2009: Brooke A Rosenzweig; Nathan T Ross; Debarati M Tagore; Janarthanan Jayawickramarajah; Ishu Saraogi; Andrew D Hamilton
Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold.
Journal of the American Chemical Society 2009;131(14):5020-1.
2009: Pauline N Wyrembak; Andrew D Hamilton
Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics.
Journal of the American Chemical Society 2009;131(13):4566-7.
2009: Johanna Rodriguez; Nathan T Ross; William P Katt; Deepali Dhar; Gui-in Lee; Andrew D Hamilton
Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface.
ChemMedChem 2009;4(4):649-56.
2009: Johanna Rodriguez; Laura Nevola; Nathan T Ross; Gui-in Lee; Andrew D Hamilton
Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold.
Chembiochem : a European journal of chemical biology 2009;10(5):829-33.
2009: Katherine J Kayser-Bricker; Matthew P Glenn; Sang Hoon Lee; Said M Sebti; Jin Q Cheng; Andrew D Hamilton
Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.
Bioorganic & medicinal chemistry 2009;17(4):1764-71.
2009: Jianfeng Cai; Erik M Shapiro; Andrew D Hamilton
Self-assembling DNA quadruplex conjugated to MRI contrast agents.
Bioconjugate chemistry 2009;20(2):205-8.
2009: Brooke A Rosenzweig; Andrew D Hamilton
Self-assembly of a four-helix bundle on a DNA quadruplex.
Angewandte Chemie (International ed. in English) 2009;48(15):2749-51.
2009: David Margulies; Andrew D Hamilton
Protein recognition by an ensemble of fluorescent DNA G-quadruplexes.
Angewandte Chemie (International ed. in English) 2009;48(10):1771-4.
2009: Jianfeng Cai; Brooke A Rosenzweig; Andrew D Hamilton
Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(2):328-32.
2009: Christopher G Cummings; Nathan T Ross; William P Katt; Andrew D Hamilton
Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic.
Organic letters 2009;11(1):25-8.
2008: Ishu Saraogi; Andrew D Hamilton
alpha-Helix mimetics as inhibitors of protein-protein interactions.
Biochemical Society transactions 2008;36(Pt 6):1414-7.
2008: Patrick T Gunning; Matthew Glenn; Khandaker A Z Siddiquee; William P Katt; Eric Masson; Saïd M Sebti; James Turkson; Andrew D Hamilton
Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders.
Chembiochem : a European journal of chemical biology 2008;9(17):2800-3.
2008: Stephen Fletcher; Christopher G Cummings; Kasey Rivas; William P Katt; Carrie Hornéy; Frederick S Buckner; Debopam Chakrabarti; Said M Sebti; Michael H Gelb; Wesley C Van Voorhis; Andrew D Hamilton
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Journal of medicinal chemistry 2008;51(17):5176-97.
2008: Ishu Saraogi; Christopher D Incarvito; Andrew D Hamilton
Controlling curvature in a family of oligoamide alpha-helix mimetics.
Angewandte Chemie (International ed. in English) 2008;47(50):9691-4.
2007: Khandaker Siddiquee; Patrick T Gunning; Matthew Glenn; William P Katt; Shumin Zhang; Christopher Schrock; Christopher Schroeck; Said M Sebti; Richard Jove; Andrew D Hamilton; James Turkson
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.
ACS chemical biology 2007;2(12):787-98.
2007: Wesley C Van Voorhis; Kasey Rivas; Pravin Bendale; Laxman Nallan; Carrie Hornéy; Lynn K Barrett; Kevin D Bauer; Brian P Smart; Sudha Ankala; Oliver Hucke; Christophe Verlinde; Debopam Chakrabarti; Corey Strickland; Kohei Yokoyama; Frederick S Buckner; Andrew D Hamilton; David K Williams; Louis J Lombardo; David Floyd; Michael H Gelb
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Antimicrobial agents and chemotherapy 2007;51(10):3659-71.
2007: Kwanghee Koh Park; Joon Woo Park; Andrew D Hamilton
Solvent and pH effects on the fluorescence of 7-(dimethylamino)-2-fluorenesulfonate.
Journal of fluorescence 2007;17(4):361-9.
2007: Patrick T Gunning; William P Katt; Matthew Glenn; Khandaker Siddiquee; Khandaker Siddique; Joon S Kim; Richard Jove; Said M Sebti; James Turkson; Andrew D Hamilton
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.
Bioorganic & medicinal chemistry letters 2007;17(7):1875-8.
2007: Katherine J Kayser; Matthew Glenn; Said M Sebti; Jin Q Cheng; Andrew D Hamilton
Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.
Bioorganic & medicinal chemistry letters 2007;17(7):2068-73.
2007: Eric Stern; James F Klemic; David A Routenberg; Pauline N Wyrembak; Daniel B Turner-Evans; Andrew D Hamilton; David A LaVan; Tarek M Fahmy; Mark A Reed
Label-free immunodetection with CMOS-compatible semiconducting nanowires.
Nature 2007;445(7127):519-22.
2007: Jessica M Davis; Lun K Tsou; Andrew D Hamilton
Synthetic non-peptide mimetics of alpha-helices.
Chemical Society reviews 2007;36(2):326-34.
2007: Frederic Delarue; Jalila Adnane; Bharat Joshi; Michelle A Blaskovich; De-an Wang; J Hawker; Francisco Bizouarn; Junko Ohkanda; K Zhu; Andrew D Hamilton; Srikumar Chellappan; Said M Sebti
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Oncogene 2007;26(5):633-40.
2007: Andrew J Wilson; Jason Hong; Stephen Fletcher; Andrew D Hamilton
Recognition of solvent exposed protein surfaces using anthracene derived receptors.
Organic & biomolecular chemistry 2007;5(2):276-85.
2007: Johanna Rodriguez; Andrew D Hamilton
Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices.
Angewandte Chemie (International ed. in English) 2007;46(45):8614-7.
2007: Janarthanan Jayawickramarajah; Debarati M Tagore; Lun K Tsou; Andrew D Hamilton
Allosteric control of self-assembly: modulating the formation of guanine quadruplexes through orthogonal aromatic interactions.
Angewandte Chemie (International ed. in English) 2007;46(40):7583-6.
2007: Stephen Fletcher; Andrew D Hamilton
Protein-protein interaction inhibitors: small molecules from screening techniques.
Current topics in medicinal chemistry 2007;7(10):922-7.
2007: Jorge Becerril; Andrew D Hamilton
Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides.
Angewandte Chemie (International ed. in English) 2007;46(24):4471-3.
2007: Ik-Hyeon Paik; Deepak Tapriyal; Robert M Enick; Andrew D Hamilton
Fiber formation by highly CO2-soluble bisureas containing peracetylated carbohydrate groups.
Angewandte Chemie (International ed. in English) 2007;46(18):3284-7.
2007: Debarati M Tagore; K Ingrid Sprinz; Stephen Fletcher; Janarthanan Jayawickramarajah; Andrew D Hamilton
Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold.
Angewandte Chemie (International ed. in English) 2007;46(1-2):223-5.
2006: Joseph T Kim; Andrew D Hamilton; Christopher M Bailey; Robert A Domaoal; Robert A Domoal; Ligong Wang; Karen S Anderson; William L Jorgensen
FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of the American Chemical Society 2006;128(48):15372-3.
2006: Vinay V Thakur; Joseph T Kim; Andrew D Hamilton; Christopher M Bailey; Robert A Domaoal; Ligong Wang; Karen S Anderson; William L Jorgensen
Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2006;16(21):5664-7.
2006: Aikaterini Anagnostopoulou; Adina Vultur; Rozanne Arulanandam; Jun Cao; James Turkson; Richard Jove; Joon S Kim; Matthew Glenn; Andrew D Hamilton; Leda Raptis
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.
Cancer letters 2006;242(1):120-32.
2006: Matthew Glenn; Sung-Youn Chang; Carrie Hornéy; Kasey Rivas; Kohei Yokoyama; Erin E Pusateri; Stephen Fletcher; Christopher G Cummings; Frederick S Buckner; Prakash Rao Pendyala; Debopam Chakrabarti; Said M Sebti; Michael H Gelb; Wesley C Van Voorhis; Andrew D Hamilton
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Journal of medicinal chemistry 2006;49(19):5710-27.
2006: Huchen Zhou; De-an Wang; Laura Baldini; Eileen Ennis; Rishi Jain; Adam Carie; Said M Sebti; Andrew D Hamilton
Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.
Organic & biomolecular chemistry 2006;4(12):2376-86.
2006: Hairuo Peng; Dora Carrico; Van Thai; Michelle A Blaskovich; Cynthia J Bucher; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
Organic & biomolecular chemistry 2006;4(9):1768-84.
2006: In Chul Kim; Andrew D Hamilton
Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix.
Organic letters 2006;8(9):1751-4.
2006: Stephen Fletcher; Andrew D Hamilton
Targeting protein-protein interactions by rational design: mimicry of protein surfaces.
Journal of the Royal Society, Interface / the Royal Society 2006;3(7):215-33.
2006: Huchen Zhou; Laura Baldini; Jason Hong; Andrew J Wilson; Andrew D Hamilton
Pattern recognition of proteins based on an array of functionalized porphyrins.
Journal of the American Chemical Society 2006;128(7):2421-5.
2006: Junko Ohkanda; Corey L Strickland; Michelle A Blaskovich; Dora Carrico; Jeffrey W Lockman; Andreas Vogt; Cynthia J Bucher; Jiazhi Sun; Yimin Qian; David Knowles; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Organic & biomolecular chemistry 2006;4(3):482-92.
2006: Juliana Ruiz-Caro; Aravind Basavapathruni; Joseph T Kim; Christopher M Bailey; Ligong Wang; Karen S Anderson; Andrew D Hamilton; William L Jorgensen
Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2006;16(3):668-71.
2006: William L Jorgensen; Juliana Ruiz-Caro; Julian Tirado-Rives; Aravind Basavapathruni; Karen S Anderson; Andrew D Hamilton
Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2006;16(3):663-7.
2005: Wayne C Guida; Andrew D Hamilton; Justin W Crotty; Said M Sebti
Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling.
Journal of computer-aided molecular design 2005;19(12):871-85.
2005: Jessica M Davis; Anh Truong; Andrew D Hamilton
Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic.
Organic letters 2005;7(24):5405-8.
2005: K Ingrid Sprinz; Debarati M Tagore; Andrew D Hamilton
Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments.
Bioorganic & medicinal chemistry letters 2005;15(17):3908-11.
2005: Xin Fan; Vijay K Potluri; M Chandler McLeod; Yang Wang; Juncheng Liu; Robert M Enick; Andrew D Hamilton; Christopher B Roberts; J Karl Johnson; Eric J Beckman
Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility.
Journal of the American Chemical Society 2005;127(33):11754-62.
2005: Matthew Glenn; Sung-Youn Chang; Oliver Hucke; Christophe Verlinde; Kasey Rivas; Carrie Hornéy; Kohei Yokoyama; Frederick S Buckner; Prakash Rao Pendyala; Debopam Chakrabarti; Michael H Gelb; Wesley C Van Voorhis; Said M Sebti; Andrew D Hamilton
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angewandte Chemie (International ed. in English) 2005;44(31):4903-6.
2005: Hang Yin; Gui-in Lee; Kristine A Sedey; Olaf Kutzki; Hyung Soon Park; Brendan P Orner; Justin T Ernst; Hong-Gang Wang; Said M Sebti; Andrew D Hamilton
Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.
Journal of the American Chemical Society 2005;127(29):10191-6.
2005: Jiazhi Sun; De-an Wang; Rishi Jain; Adam Carie; Steve Paquette; Eileen Ennis; Michelle A Blaskovich; Laura Baldini; Domenico Coppola; Andrew D Hamilton; Said M Sebti
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.
Oncogene 2005;24(29):4701-9.
2005: Hang Yin; Andrew D Hamilton
Strategies for targeting protein-protein interactions with synthetic agents.
Angewandte Chemie (International ed. in English) 2005;44(27):4130-63.
2005: Hang Yin; Gui-in Lee; Hyung Soon Park; Gregory A Payne; Johanna Rodriguez; Said M Sebti; Andrew D Hamilton
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.
Angewandte Chemie (International ed. in English) 2005;44(18):2704-7.
2005: Hang Yin; Gui-in Lee; Kristine A Sedey; Johanna Rodriguez; Hong-Gang Wang; Said M Sebti; Andrew D Hamilton
Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction.
Journal of the American Chemical Society 2005;127(15):5463-8.
2005: Dora Carrico; Michelle A Blaskovich; Cynthia J Bucher; Said M Sebti; Andrew D Hamilton
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
Bioorganic & medicinal chemistry 2005;13(3):677-88.
2005: Thomas J Magliery; Christopher G M Wilson; Weilan Pan; Dennis Mishler; Indraneel Ghosh; Andrew D Hamilton; Lynne Regan
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism.
Journal of the American Chemical Society 2005;127(1):146-57.
2005: Jeffrey W Lockman; Andrew D Hamilton
Recent developments in the identification of chemotherapeutics for Chagas disease.
Current medicinal chemistry 2005;12(8):945-59.
2004: Dora Carrico; Junko Ohkanda; Howard Kendrick; Kohei Yokoyama; Michelle A Blaskovich; Cynthia J Bucher; Frederick S Buckner; Wesley C Van Voorhis; Debopam Chakrabarti; Simon L Croft; Michael H Gelb; Said M Sebti; Andrew D Hamilton
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
2004: Kevin Groves; Andrew J Wilson; Andrew D Hamilton
Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents.
Journal of the American Chemical Society 2004;126(40):12833-42.
2004: Jiazhi Sun; Michelle A Blaskovich; Rishi Jain; Frederic Delarue; Daniel Paris; Steven Brem; Marguerite Wotoczek-Obadia; Qing Lin; Domenico Coppola; Kihang Choi; Michael Mullan; Andrew D Hamilton; Said M Sebti
Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.
Cancer research 2004;64(10):3586-92.
2004: Laura Baldini; Andrew J Wilson; Jason Hong; Andrew D Hamilton
Pattern-based detection of different proteins using an array of fluorescent protein surface receptors.
Journal of the American Chemical Society 2004;126(18):5656-7.
2004: Hang Yin; Andrew D Hamilton
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein.
Bioorganic & medicinal chemistry letters 2004;14(6):1375-9.
2004: James Turkson; Joon S Kim; Shumin Zhang; Jing Yuan; Mei Huang; Matthew Glenn; Eric Haura; Said Sebti; Andrew D Hamilton; Richard Jove
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.
Molecular cancer therapeutics 2004;3(3):261-9.
2004: Lara A Estroff; Andrew D Hamilton
Water gelation by small organic molecules.
Chemical reviews 2004;104(3):1201-18.
2004: Junko Ohkanda; Frederick S Buckner; Jeffrey W Lockman; Kohei Yokoyama; Dora Carrico; Richard Eastman; Kate de Luca-Fradley; Wendy Davies; Simon L Croft; Wesley C Van Voorhis; Michael H Gelb; Said M Sebti; Andrew D Hamilton
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2004: Lara A Estroff; Christopher D Incarvito; Andrew D Hamilton
Design of a synthetic foldamer that modifies the growth of calcite crystals.
Journal of the American Chemical Society 2004;126(1):2-3.
2004: Lara A Estroff; Lia Addadi; Steve Weiner; Andrew D Hamilton
An organic hydrogel as a matrix for the growth of calcite crystals.
Organic & biomolecular chemistry 2004;2(1):137-41.
2004: Rishi Jain; Justin T Ernst; Olaf Kutzki; Hyung Soon Park; Andrew D Hamilton
Protein recognition using synthetic surface-targeted agents.
Molecular diversity 2004;8(2):89-100.
2004: Xavier Salvatella; Marc Martinell; Margarida Gairí; Mauricio G Mateu; Miguel Feliz; Andrew D Hamilton; Javier de Mendoza; Ernest Giralt
A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53.
Angewandte Chemie (International ed. in English) 2004;43(2):196-8.
2003: Lara A Estroff; Jessica S Huang; Andrew D Hamilton
Fiber formation in water by a mono-urea dicarboxylic acid.
Chemical communications (Cambridge, England) 2003;(24):2958-9.
2003: Jiazhi Sun; Junko Ohkanda; Domenico Coppola; Hang Yin; Mohit Kothare; Brian Busciglio; Andrew D Hamilton; Said M Sebti
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Cancer research 2003;63(24):8922-9.
2003: Kuichun Zhu; Andrew D Hamilton; Said M Sebti
Farnesyltransferase inhibitors as anticancer agents: current status.
Current opinion in investigational drugs (London, England : 2000) 2003;4(12):1428-35.
2003: Kihang Choi; Andrew D Hamilton
Rigid macrocyclic triamides as anion receptors: anion-dependent binding stoichiometries and 1H chemical shift changes.
Journal of the American Chemical Society 2003;125(34):10241-9.
2003: Toshihiro Aya; Andrew D Hamilton
Tetrabiphenylporphyrin-based receptors for protein surfaces show sub-nanomolar affinity and enhance unfolding.
Bioorganic & medicinal chemistry letters 2003;13(16):2651-4.
2003: Bruno B Bordier; Junko Ohkanda; Ping Liu; So-Young Lee; F H Salazar; Patricia L Marion; Kazuo Ohashi; Leonard Meuse; Mark A Kay; John L Casey; Said M Sebti; Andrew D Hamilton; Jeffrey S Glenn
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
The Journal of clinical investigation 2003;112(3):407-14.
2003: Andrew J Wilson; Kevin Groves; Rishi Jain; Hyung Soon Park; Andrew D Hamilton
Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer.
Journal of the American Chemical Society 2003;125(15):4420-1.
2003: Guijun Wang; Andrew D Hamilton
Low molecular weight organogelators for water.
Chemical communications (Cambridge, England) 2003;(3):310-1.
2003: Justin T Ernst; Jorge Becerril; Hyung Soon Park; Hang Yin; Andrew D Hamilton
Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex.
Angewandte Chemie (International ed. in English) 2003;42(5):535-9.
2003: Junko Ohkanda; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.
Progress in cell cycle research 2003;5():211-7.
2002: Cuider Allal; Anne Pradines; Andrew D Hamilton; Said M Sebti; Gilles FAVRE
Farnesylated RhoB prevents cell cycle arrest and actin cytoskeleton disruption caused by the geranylgeranyltransferase I inhibitor GGTI-298.
Cell cycle (Georgetown, Tex.) 2002;1(6):430-7.
2002: Olaf Kutzki; Hyung Soon Park; Justin T Ernst; Brendan P Orner; Hang Yin; Andrew D Hamilton
Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry.
Journal of the American Chemical Society 2002;124(40):11838-9.
2002: Qian Zhao; Justin T Ernst; Andrew D Hamilton; Asim K Debnath; Shibo Jiang
XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41.
AIDS research and human retroviruses 2002;18(14):989-97.
2002: Vijay K Potluri; Jianhang Xu; Robert M Enick; Eric J Beckman; Andrew D Hamilton
Peracetylated sugar derivatives show high solubility in liquid and supercritical carbon dioxide.
Organic letters 2002;4(14):2333-5.
2002: N C Crespo; Frederic Delarue; Junko Ohkanda; Dora Carrico; Andrew D Hamilton; Said M Sebti
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.
Cell death and differentiation 2002;9(7):702-9.
2002: Xianwu Li; Li Liu; Joan C Tupper; Douglas D Bannerman; Robert K Winn; Said M Sebti; Andrew D Hamilton; John M Harlan
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
The Journal of biological chemistry 2002;277(18):15309-16.
2002: Hyung Soon Park; Qing Lin; Andrew D Hamilton
Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5105-9.
2002: Guijun Wang; Andrew D Hamilton
Synthesis and self-assembling properties of polymerizable organogelators.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(8):1954-61.
2002: Junko Ohkanda; David B Knowles; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Inhibitors of protein farnesyltransferase as novel anticancer agents.
Current topics in medicinal chemistry 2002;2(3):303-23.
2002: Justin T Ernst; Olaf Kutzki; Asim K Debnath; Shibo Jiang; Hong Lu; Andrew D Hamilton
Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion.
Angewandte Chemie (International ed. in English) 2002;41(2):278-81.
2002: Brendan P Orner; Xavier Salvatella; Jorge Sánchez-Quesada; Javier de Mendoza; Ernest Giralt; Andrew D Hamilton
De novo protein surface design: use of cation-pi interactions to enhance binding between an alpha-helical peptide and a cationic molecule in 50 % aqueous solution.
Angewandte Chemie (International ed. in English) 2002;41(1):117-9.
2002: Junko Ohkanda; Jeffrey W Lockman; Mohit A Kothare; Yimin Qian; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Journal of medicinal chemistry 2002;45(1):177-88.
2001: James Turkson; D Ryan; Joon S Kim; Y Zhang; Z Chen; Eric Haura; A Laudano; Said Sebti; Andrew D Hamilton; Richard Jove
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.
The Journal of biological chemistry 2001;276(48):45443-55.
2001: BR Linton; M S Goodman; E Fan; S A van Arman; Andrew D Hamilton
Thermodynamic aspects of dicarboxylate recognition by simple artificial receptors.
The Journal of organic chemistry 2001;66(22):7313-9.
2001: Umberto Kucich; J C Rosenbloom; David J Herrick; William Abrams; Andrew D Hamilton; Said M Sebti; Joel Rosenbloom
Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts.
Archives of biochemistry and biophysics 2001;395(1):103-12.
2001: Y Hamuro; Andrew D Hamilton
Functionalized oligoanthranilamides: modular and conformationally controlled scaffolds.
Bioorganic & medicinal chemistry 2001;9(9):2355-63.
2001: Brendan P Orner; Justin T Ernst; Andrew D Hamilton
Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix.
Journal of the American Chemical Society 2001;123(22):5382-3.
2001: N C Crespo; Junko Ohkanda; T J Yen; Andrew D Hamilton; Said M Sebti
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.
The Journal of biological chemistry 2001;276(19):16161-7.
2001: Junko Ohkanda; Jeffrey W Lockman; Kohei Yokoyama; Michael H Gelb; Simon L Croft; H Kendrick; M I Harrell; JE Feagin; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.
2001: Kihang Choi; Andrew D Hamilton
Selective anion binding by a macrocycle with convergent hydrogen bonding functionality.
Journal of the American Chemical Society 2001;123(10):2456-7.
2001: Jiazhi Sun; S Nam; C S Lee; B Li; Domenico Coppola; Andrew D Hamilton; Qingping Dou; Said M Sebti
CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice.
Cancer research 2001;61(4):1280-4.
2000: Said M Sebti; Andrew D Hamilton
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.
Expert opinion on investigational drugs 2000;9(12):2767-82.
2000: Jalila Adnane; Francisco Bizouarn; Zhi Chen; Junko Ohkanda; Andrew D Hamilton; T Munoz-Antonia; Said M Sebti
Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.
Oncogene 2000;19(48):5525-33.
2000: Cuider Allal; Gilles FAVRE; Bettina Couderc; S Salicio; S Sixou; Andrew D Hamilton; Said M Sebti; Isabelle Lajoie-Mazenc; Anne Pradines
RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.
The Journal of biological chemistry 2000;275(40):31001-8.
2000: Sheng Wei; Danielle L Gilvary; Brian C Corliss; Said Sebti; Jiazhi Sun; D B Straus; P J Leibson; J A Trapani; Andrew D Hamilton; M J Weber; Julie Y Djeu
Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3811-9.
2000: Michelle A Blaskovich; Q Lin; Frederic Delarue; Jiazhi Sun; H S Park; Domenico Coppola; Andrew D Hamilton; Said M Sebti
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.
Nature biotechnology 2000;18(10):1065-70.
2000: Elizabeth Cohen-Jonathan; Ruth J Muschel; W Gillies McKenna; Sydney Evans; george cerniglia; Rosemarie Mick; D Kusewitt; Said M Sebti; Andrew D Hamilton; Allen Oliff; Nancy E Kohl; Jackson B Gibbs; Eric J Bernhard
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
Radiation research 2000;154(2):125-32.
2000: BR Linton; M S Goodman; Andrew D Hamilton
Nitronate anion recognition and modulation of ambident reactivity by hydrogen-bonding receptors.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(13):2449-55.
2000: Joel Rosenbloom; Biagio Saitta; Svetlana Gaidarova; Nora Sandorfi; J C Rosenbloom; William Abrams; Andrew D Hamilton; Said M Sebti; Umberto Kucich; Sergio A Jimenez
Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I.
Arthritis and rheumatism 2000;43(7):1624-32.
2000: Rishi Jain; Andrew D Hamilton
Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold.
Organic letters 2000;2(12):1721-3.
2000: Umberto Kucich; J C Rosenbloom; G Shen; William Abrams; Andrew D Hamilton; Said M Sebti; Joel Rosenbloom
TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2.
Archives of biochemistry and biophysics 2000;374(2):313-24.
2000: Said M Sebti; Andrew D Hamilton
Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors.
Methods in enzymology 2000;325():381-8.
1999: Yimin Qian; J J Marugan; R D Fossum; Andreas Vogt; Said M Sebti; Andrew D Hamilton
Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.
Bioorganic & medicinal chemistry 1999;7(12):3011-24.
1999: J Sun; Michelle A Blaskovich; D Knowles; Y Qian; Junko Ohkanda; Ratna D Bailey; Andrew D Hamilton; Said M Sebti
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Cancer research 1999;59(19):4919-26.
1999: Elizabeth Cohen-Jonathan; Christine Toulas; Isabelle Ader; S Monteil; Cuider Allal; Jacques Bonnet; Andrew D Hamilton; Said M Sebti; Nicolas Daly-Schveitzer; Gilles FAVRE
The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS.
Radiation research 1999;152(4):404-11.
1999: BR Linton; Andrew D Hamilton
Host-guest chemistry: combinatorial receptors.
Current opinion in chemical biology 1999;3(3):307-12.
1999: A Vasudevan; Yimin Qian; Andreas Vogt; Michelle A Blaskovich; Junko Ohkanda; Said M Sebti; Andrew D Hamilton
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Journal of medicinal chemistry 1999;42(8):1333-40.
1999: Jiazhi Sun; Y Qian; Zhi Chen; J Marfurt; Andrew D Hamilton; Said M Sebti
The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity.
The Journal of biological chemistry 1999;274(11):6930-4.
1998: TA Sharma; A J Carr; R S Davis; Ian J Reynolds; Andrew D Hamilton
Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor.
Bioorganic & medicinal chemistry letters 1998;8(24):3459-64.
1998: Jalila Adnane; Francisco Bizouarn; Y Qian; Andrew D Hamilton; Said M Sebti
p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.
Molecular and cellular biology 1998;18(12):6962-70.
1998: Umberto Kucich; J C Rosenbloom; G Shen; William Abrams; Michelle A Blaskovich; Andrew D Hamilton; Junko Ohkanda; Said M Sebti; Joel Rosenbloom
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Biochemical and biophysical research communications 1998;252(1):111-6.
1998: W W Stark; Michelle A Blaskovich; B A Johnson; Yimin Qian; A Vasudevan; Bruce R Pitt; Andrew D Hamilton; Said M Sebti; P Davies
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
The American journal of physiology 1998;275(1 Pt 1):L55-63.
1998: Eric J Bernhard; W Gillies McKenna; Andrew D Hamilton; Said M Sebti; Y Qian; J M Wu; Ruth J Muschel
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
Cancer research 1998;58(8):1754-61.
1998: W S Weiner; Andrew D Hamilton
Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides.
Bioorganic & medicinal chemistry letters 1998;8(6):681-6.
1998: Yimin Qian; Andreas Vogt; A Vasudevan; Said M Sebti; Andrew D Hamilton
Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics.
Bioorganic & medicinal chemistry 1998;6(3):293-9.
1998: Q Lin; H S Park; Y Hamuro; C S Lee; Andrew D Hamilton
Protein surface recognition by synthetic agents: design and structural requirements of a family of artificial receptors that bind to cytochrome c.
Biopolymers 1998;47(4):285-97.
1997: H Chen; W S Weiner; Andrew D Hamilton
Recognition of neutral species with synthetic receptors.
Current opinion in chemical biology 1997;1(4):458-66.
1997: Said M Sebti; Andrew D Hamilton
Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development.
Expert opinion on investigational drugs 1997;6(11):1711-4.
1997: Said Sebti; Andrew D Hamilton
Inhibitors of prenyl transferases.
Current opinion in oncology 1997;9(6):557-61.
1997: Andreas Vogt; J Sun; Yimin Qian; Andrew D Hamilton; Said M Sebti
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
The Journal of biological chemistry 1997;272(43):27224-9.
1997: Edwina C Lerner; TT Zhang; D B Knowles; Yimin Qian; Andrew D Hamilton; Said M Sebti
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Oncogene 1997;15(11):1283-8.
1997: J S Albert; M W Peczuh; Andrew D Hamilton
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an alpha-helical conformation.
Bioorganic & medicinal chemistry 1997;5(8):1455-67.
1997: E C Lerner; Andrew D Hamilton; S M Sebti
Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design.
Anti-cancer drug design 1997;12(4):229-38.
1997: Jonathan D Finder; J L Litz; Michelle A Blaskovich; Terence F Mcguire; Yimin Qian; Andrew D Hamilton; P Davies; Said M Sebti
Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
The Journal of biological chemistry 1997;272(21):13484-8.
1997: K Miquel; Anne Pradines; J Sun; Y Qian; Andrew D Hamilton; Said M Sebti; Gilles FAVRE
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
Cancer research 1997;57(10):1846-50.
1997: Said M Sebti; Andrew D Hamilton
Inhibition of Ras prenylation: a novel approach to cancer chemotherapy.
Pharmacology & therapeutics 1997;74(1):103-14.
1997: Yimin Qian; Said M Sebti; Andrew D Hamilton
Farnesyltransferase as a target for anticancer drug design.
Biopolymers 1997;43(1):25-41.
1996: Andreas Vogt; Yimin Qian; Terence F Mcguire; Andrew D Hamilton; Said M Sebti
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Oncogene 1996;13(9):1991-9.
1996: Terence F Mcguire; Yimin Qian; Andreas Vogt; Andrew D Hamilton; Said M Sebti
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
The Journal of biological chemistry 1996;271(44):27402-7.
1996: Said M Sebti; Andrew D Hamilton
Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs.
Biochemical Society transactions 1996;24(3):692-9.
1996: R B Hopkins; J S Albert; D Van Engen; Andrew D Hamilton
Synthesis and structure of chiral macrocycles containing 2,2'-bipyridine subunits.
Bioorganic & medicinal chemistry 1996;4(7):1121-8.
1996: Eric J Bernhard; Gary D Kao; Adrienne D Cox; Said M Sebti; Andrew D Hamilton; Ruth J Muschel; W Gillies McKenna
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.
Cancer research 1996;56(8):1727-30.
1996: Yimin Qian; Andreas Vogt; Said M Sebti; Andrew D Hamilton
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.
Journal of medicinal chemistry 1996;39(1):217-23.
1995: R C Kauffmann; Yimin Qian; Andreas Vogt; Said M Sebti; Andrew D Hamilton; Richard W Carthew
Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10919-23.
1995: E C Lerner; Yimin Qian; Michelle A Blaskovich; R D Fossum; Andreas Vogt; J Sun; Adrienne D Cox; Channing J Der; Andrew D Hamilton; Said M Sebti
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
The Journal of biological chemistry 1995;270(45):26802-6.
1995: E C Lerner; Yimin Qian; Andrew D Hamilton; Said M Sebti
Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
The Journal of biological chemistry 1995;270(45):26770-3.
1995: J Sun; Yimin Qian; Andrew D Hamilton; Said M Sebti
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
Cancer research 1995;55(19):4243-7.
1995: Andreas Vogt; J Sun; Yimin Qian; E Tan-Chiu; Andrew D Hamilton; Said M Sebti
Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.
Biochemistry 1995;34(38):12398-403.
1995: Terence F Mcguire; Yimin Qian; Michelle A Blaskovich; R D Fossum; J Sun; T Marlowe; Seth J Corey; S P Wathen; Andreas Vogt; Andrew D Hamilton
CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.
Biochemical and biophysical research communications 1995;214(1):295-303.
1995: J S Albert; Andrew D Hamilton
Stabilization of helical domains in short peptides using hydrophobic interactions.
Biochemistry 1995;34(3):984-90.
1995: Andreas Vogt; Yimin Qian; Michelle A Blaskovich; R D Fossum; Andrew D Hamilton; Said M Sebti
A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.
The Journal of biological chemistry 1995;270(2):660-4.
1994: Yimin Qian; Michelle A Blaskovich; M Saleem; C M Seong; S P Wathen; Andrew D Hamilton; Said M Sebti
Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.
The Journal of biological chemistry 1994;269(17):12410-3.
1993: M Nigam; C M Seong; Yimin Qian; Andrew D Hamilton; Said M Sebti
Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.
The Journal of biological chemistry 1993;268(28):20695-8.