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Robert Hammer

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Joshua L Owen; Yuanyuan Zhang; Soo-Han Bae; Midhat S Farooqi; Joseph L Goldstein; Robert E Hammer; Guosheng Liang; Michael S Brown
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.
Joel D Taurog; Leonie M van Duivenvoorde; Martha L Dorris; Robert E Hammer; F Kent Hamra; James A Richardson; Claudia Rival; Nimman Satumtira; John M Shelton; Margaret Sun; Kenneth S K Tung
Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats.
Zhengliang Gao; Robert E Hammer; Peiguo Ding; Jing Ma; Mostafa Nashaat; Kerstin Ure; Laura Yuan; Jenny Hsieh
The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.

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2012: Joshua L Owen; Yuanyuan Zhang; Soo-Han Bae; Midhat S Farooqi; Joseph L Goldstein; Robert E Hammer; Guosheng Liang; Michael S Brown
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(40):16184-9.
2012: Joel D Taurog; Leonie M van Duivenvoorde; Martha L Dorris; Robert E Hammer; F Kent Hamra; James A Richardson; Claudia Rival; Nimman Satumtira; John M Shelton; Margaret Sun; Kenneth S K Tung
Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats.
Arthritis and rheumatism 2012;64(8):2518-28.
2011: Zhengliang Gao; Robert E Hammer; Peiguo Ding; Jing Ma; Mostafa Nashaat; Kerstin Ure; Laura Yuan; Jenny Hsieh
The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(26):9772-86.
2010: Yaz Y Kisanuki; Noriaki Emoto; Takashi Ohuchi; Bambang Widyantoro; Keiko Yagi; Kazuhiko Nakayama; Rafal M Kedzierski; Robert E Hammer; Hiromi Yanagisawa; S Clay Williams; James A Richardson; Takashi Suzuki; Masashi Yanagisawa
Low blood pressure in endothelial cell-specific endothelin 1 knockout mice.
Hypertension 2010;56(1):121-8.
2010: Jose A Barrera; Ling-Rong Kao; Robert E Hammer; Joachim Seemann; Jannon L Fuchs; Timothy L Megraw
CDK5RAP2 regulates centriole engagement and cohesion in mice.
Developmental cell 2010;18(6):913-26.
2010: Yi Li; Jie Hu; Klemens Höfer; Andrew M S Wong; Jonathan D Cooper; Shari G Birnbaum; Robert E Hammer; Hofmann Sandra
DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory.
The Journal of biological chemistry 2010;285(17):13022-31.
2010: Matthew S Alexander; Xiaozhong Shi; Kevin A Voelker; Robert W Grange; Joseph A Garcia; Robert E Hammer; Daniel J Garry
Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity.
Developmental biology 2010;337(2):396-404.
2009: Young-Ah Moon; Robert E Hammer; Jay D Horton
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
Journal of lipid research 2009;50(3):412-23.
2009: Víctor Cortés; David E Curtis; Suja Sukumaran; Xinli Shao; Vinay Parameswara; Shirya Rashid; Amy R Smith; Jimin Ren; Victoria Esser; Robert E Hammer; Anil Agarwal; Jay D Horton; Abhimanyu Garg
Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.
Cell metabolism 2009;9(2):165-76.
2009: Cory R Nicholas; Eugene Yujun Xu; Salman F Banani; Robert E Hammer; F Kent Hamra; Renee A Reijo Pera
Characterization of a Dazl-GFP germ cell-specific reporter.
Genesis (New York, N.Y. : 2000) 2009;47(2):74-84.
2009: Anwarul Ferdous; Arianna Caprioli; Michelina Iacovino; Cindy M Martin; Jesse Morris; James A Richardson; Shuaib Latif; Robert E Hammer; Richard P Harvey; Eric N Olson; Michael Kyba; Daniel J Garry
Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):814-9.
2009: Timothy E Richardson; Karen M Chapman; Christina Tenenhaus Dann; Robert E Hammer; F Kent Hamra
Sterile testis complementation with spermatogonial lines restores fertility to DAZL-deficient rats and maximizes donor germline transmission.
PloS one 2009;4(7):e6308.
2008: Buck S Samuel; Abdullah Shaito; Toshiyuki Motoike; Federico E Rey; Fredrik Backhed; Jill K Manchester; Robert E Hammer; S Clay Williams; Jan Crowley; Masashi Yanagisawa; Jeffrey I Gordon
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16767-72.
2008: Wei Tang; Daniel Zeve; Jae Myoung Suh; Darko Bosnakovski; Michael Kyba; Robert E Hammer; Michelle Tallquist; Jonathan M Graff
White fat progenitor cells reside in the adipose vasculature.
Science (New York, N.Y.) 2008;322(5901):583-6.
2008: S Kotadia; Ling-Rong Kao; S A Comerford; R T Jones; Robert E Hammer; Timothy L Megraw
PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.
Oncogene 2008;27(49):6334-46.
2008: Stefan H Gerber; Jong-Cheol Rah; sang-won min; Xinran Liu; Heidi de Wit; Irina Dulubova; Alexander C Meyer; Josep Rizo; Marife Arancillo; Robert E Hammer; Matthijs Verhage; christian rosenmund; Thomas C Südhof
Conformational switch of syntaxin-1 controls synaptic vesicle fusion.
Science (New York, N.Y.) 2008;321(5895):1507-10.
2008: Jing Hao; Miwako Yamamoto; Timothy E Richardson; Karen M Chapman; Bray S Denard; Robert E Hammer; Guang-Quan Zhao; F Kent Hamra
Sohlh2 knockout mice are male-sterile because of degeneration of differentiating type A spermatogonia.
Stem cells (Dayton, Ohio) 2008;26(6):1587-97.
2008: Youn-Kyoung Lee; Daniel R Schmidt; Carolyn L Cummins; Mihwa Choi; Li Peng; Yuan Zhang; Bryan Goodwin; Robert E Hammer; David J Mangelsdorf; Steven A Kliewer
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1345-56.
2007: Katsuhiko Tabuchi; Jacqueline Blundell; Mark R Etherton; Robert E Hammer; Xinran Liu; Craig M Powell; Thomas C Südhof
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Science (New York, N.Y.) 2007;318(5847):71-6.
2007: Takeshi Inagaki; Paul Anthony Dutchak; Guixiang Zhao; Xunshan Ding; Laurent Gautron; Vinay Parameswara; Yong Li; Regina Goetz; Moosa Mohammadi; Victoria Esser; Joel K Elmquist; Robert D Gerard; Shawn C Burgess; Robert E Hammer; David J Mangelsdorf; Steven A Kliewer
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
Cell metabolism 2007;5(6):415-25.
2007: Annette P Meeson; Xiaozhong Shi; Matthew S Alexander; R Sanders Williams; Ronald E Allen; Nan Jiang; Ibrahim M Adham; Sean C Goetsch; Robert E Hammer; Daniel J Garry
Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells.
The EMBO journal 2007;26(7):1902-12.
2006: Uwe Beffert; Farnas Nematollah Farsian; Irene Masiulis; Robert E Hammer; Sung Ok Yoon; Klaus M Giehl; Joachim Herz
ApoE receptor 2 controls neuronal survival in the adult brain.
Current biology : CB 2006;16(24):2446-52.
2006: Angela Ho; Wade Morishita; Deniz Atasoy; Xinran Liu; Katsuhiko Tabuchi; Robert E Hammer; Robert C Malenka; Thomas C Südhof
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(50):13089-101.
2006: Susanne Schoch; Tobias Mittelstaedt; Pascal S Kaeser; Daniel Padgett; Nicole Feldmann; Vivien Chevaleyre; Pablo E Castillo; Robert E Hammer; Weiping Han; Frank Schmitz; Weichun Lin; Thomas C Südhof
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
The EMBO journal 2006;25(24):5852-63.
2006: Thomas A Lagace; David E Curtis; Rita Garuti; Markey C McNutt; Sahng Wook Park; Heidi B Prather; Norma N Anderson; Yiu-Kee Ho; Robert E Hammer; Jay D Horton
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.
The Journal of clinical investigation 2006;116(11):2995-3005.
2006: Yildiz Yildiz; Heidrun Matern; Bonne Thompson; Jeremy C Allegood; Rebekkah L Warren; Denise M O Ramirez; Robert E Hammer; F Kent Hamra; Siegfried Matern; David W Russell
Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility.
The Journal of clinical investigation 2006;116(11):2985-94.
2006: Christina Tenenhaus Dann; Alma L Alvarado; Robert E Hammer; David L Garbers
Heritable and stable gene knockdown in rats.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11246-51.
2006: Tri M Tran; Martha L Dorris; Nimman Satumtira; James A Richardson; Robert E Hammer; Jie Shang; Joel D Taurog
Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats.
Arthritis and rheumatism 2006;54(4):1317-27.
2006: Uwe Beffert; Andre Durudas; Edwin J Weeber; Peggy C Stolt; Klaus M Giehl; J David Sweatt; Robert E Hammer; Joachim Herz
Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(7):2041-52.
2006: Suzanne Y Guénette; Yang Chang; Thomas Hiesberger; James A Richardson; Christopher B Eckman; Elizabeth A Eckman; Robert E Hammer; Joachim Herz
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
The EMBO journal 2006;25(2):420-31.
2005: F Kent Hamra; Karen M Chapman; Derek M Nguyen; Ashley A Williams-Stephens; Robert E Hammer; David L Garbers
Self renewal, expansion, and transfection of rat spermatogonial stem cells in culture.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17430-5.
2005: Michael A Hale; Hideaki Kagami; Ling Shi; Andrew M Holland; Hans-Peter Elsässer; Robert E Hammer; Raymond J MacDonald
The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas.
Developmental biology 2005;286(1):225-37.
2005: Luke J Engelking; Guosheng Liang; Robert E Hammer; Kiyosumi Takaishi; Hiroshi Kuriyama; Bret M Evers; Wei-Ping Li; Jay D Horton; Joseph L Goldstein; Michael S Brown
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
The Journal of clinical investigation 2005;115(9):2489-98.
2005: Uwe Beffert; Edwin J Weeber; Andre Durudas; Shenfeng Qiu; Irene Masiulis; J David Sweatt; Wei-Ping Li; Giselind Adelmann; Michael Frotscher; Robert E Hammer; Joachim Herz
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2.
Neuron 2005;47(4):567-79.
2005: Jennifer T Cronkhite; Carola Norlander; Jenny K Furth; Göran Levan; David L Garbers; Robert E Hammer
Male and female germline specific expression of an EGFP reporter gene in a unique strain of transgenic rats.
Developmental biology 2005;284(1):171-83.
2005: Michele A Kelly; Carsten T Beuckmann; S Clay Williams; Christopher M Sinton; Toshiyuki Motoike; James A Richardson; Robert E Hammer; Mary G Garry; Masashi Yanagisawa
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9942-7.
2005: Weiqi Zhang; Astrid Rohlmann; Vardanush Sargsyan; Gayane Aramuni; Robert E Hammer; Thomas C Südhof; Markus Missler
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(17):4330-42.
2005: Shirya Rashid; David E Curtis; Rita Garuti; Norma N Anderson; Yuriy Bashmakov; Yiu-Kee Ho; Robert E Hammer; Young-Ah Moon; Jay D Horton
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(15):5374-9.
2005: Weiping Han; Jeong-Seop Rhee; Anton Maximov; Weichun Lin; Robert E Hammer; christian rosenmund; Thomas C Südhof
C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.
The Journal of biological chemistry 2005;280(6):5089-100.
2004: Naohisa Tamura; Lynda K Doolittle; Robert E Hammer; John M Shelton; James A Richardson; David L Garbers
Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17300-5.
2004: Sreeganga Chandra; Francesco Fornai; Hyung-Bae Kwon; Umar Yazdani; Deniz Atasoy; Xinran Liu; Robert E Hammer; Giuseppe Battaglia; Dwight C German; Pablo E Castillo; Thomas C Südhof
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14966-71.
2004: F Kent Hamra; Nikolaus Schultz; Karen M Chapman; Dana M Grellhesl; Jennifer T Cronkhite; Robert E Hammer; David L Garbers
Defining the spermatogonial stem cell.
Developmental biology 2004;269(2):393-410.
2004: Carsten T Beuckmann; Christopher M Sinton; S Clay Williams; James A Richardson; Robert E Hammer; Takeshi Sakurai; Masashi Yanagisawa
Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(18):4469-77.
2004: Peter Marschang; Jochen Brich; Edwin J Weeber; J David Sweatt; John M Shelton; James A Richardson; Robert E Hammer; Joachim Herz
Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
Molecular and cellular biology 2004;24(9):3782-93.
2004: Luke J Engelking; Hiroshi Kuriyama; Robert E Hammer; Jay D Horton; Michael S Brown; Joseph L Goldstein; Guosheng Liang
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
The Journal of clinical investigation 2004;113(8):1168-75.
2003: Timothy A Quill; Sarah A Sugden; Kristen L Rossi; Lynda K Doolittle; Robert E Hammer; David L Garbers
Hyperactivated sperm motility driven by CatSper2 is required for fertilization.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14869-74.
2003: Louis-Bruno Ruest; Robert E Hammer; Masashi Yanagisawa; David E Clouthier
Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain.
Genesis (New York, N.Y. : 2000) 2003;37(4):188-94.
2003: Rafal M Kedzierski; Paul A Grayburn; Yaz Y Kisanuki; Clay S Williams; Robert E Hammer; James A Richardson; Micheal D Schneider; Masashi Yanagisawa
Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol.
Molecular and cellular biology 2003;23(22):8226-32.
2003: Teresa D Gallardo; Robert E Hammer; Daniel J Garry
RNA amplification and transcriptional profiling for analysis of stem cell populations.
Genesis (New York, N.Y. : 2000) 2003;37(2):57-63.
2003: Jay D Horton; Iichiro Shimomura; Shinji Ikemoto; Yuriy Bashmakov; Robert E Hammer
Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.
The Journal of biological chemistry 2003;278(38):36652-60.
2003: David E Clouthier; S Clay Williams; Robert E Hammer; James A Richardson; Masashi Yanagisawa
Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development.
Developmental biology 2003;261(2):506-19.
2003: Christopher Jones; Robert E Hammer; Wei-Ping Li; Jonathan C Cohen; Helen H Hobbs; Joachim Herz
Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia.
The Journal of biological chemistry 2003;278(31):29024-30.
2003: Markus Missler; Weiqi Zhang; Astrid Rohlmann; Gunnar Kattenstroth; Robert E Hammer; Kurt Gottmann; Thomas C Südhof
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.
Nature 2003;423(6943):939-48.
2003: Jon T Willie; Richard M Chemelli; Christopher M Sinton; Shigeru Tokita; S Clay Williams; Yaz Y Kisanuki; Jacob N Marcus; Charlotte Lee; Joel K Elmquist; Kristi A Kohlmeier; Christopher S Leonard; James A Richardson; Robert E Hammer; Masashi Yanagisawa
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
Neuron 2003;38(5):715-30.
2003: Louis-Bruno Ruest; Marcus Dager; Hiromi Yanagisawa; Jeroen Charité; Robert E Hammer; Eric N Olson; Masashi Yanagisawa; David E Clouthier
dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development.
Developmental biology 2003;257(2):263-77.
2003: Sarah A Comerford; David E Clouthier; Elizabeth A Hinnant; Robert E Hammer
Induction of hepatocyte proliferation and death by modulation of T-Antigen expression.
Oncogene 2003;22(16):2515-30.
2003: Michael Gotthardt; Robert E Hammer; Norbert Hübner; Jan Monti; Christian C Witt; Mark McNabb; James A Richardson; Henk Granzier; Siegfried Labeit; Joachim Herz
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.
The Journal of biological chemistry 2003;278(8):6059-65.
2003: Angela Ho; Wade Morishita; Robert E Hammer; Robert C Malenka; Thomas C Sudhof
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1409-14.
2002: Liqing Yu; Robert E Hammer; Jia Li-Hawkins; Klaus Von Bergmann; Dieter Lutjohann; Jonathan C Cohen; Helen H Hobbs
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16237-42.
2002: F Kent Hamra; Joel Gatlin; Karen M Chapman; Dana M Grellhesl; Jose Garcia-Martinez; Robert E Hammer; David L Garbers
Production of transgenic rats by lentiviral transduction of male germ-line stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14931-6.
2002: Andrew M Holland; Michael A Hale; Hideaki Kagami; Robert E Hammer; Raymond J MacDonald
Experimental control of pancreatic development and maintenance.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12236-41.
2002: Liqing Yu; Jia Li-Hawkins; Robert E Hammer; Knut E Berge; Jay D Horton; Jonathan C Cohen; Helen H Hobbs
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.
The Journal of clinical investigation 2002;110(5):671-80.
2002: Rita Holtwick; Michael Gotthardt; Boris Skryabin; Martin Steinmetz; Regine Potthast; Bernd Zetsche; Robert E Hammer; Joachim Herz; Michaela Kuhn
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):7142-7.
2002: Guosheng Liang; Jian Yang; Jay D Horton; Robert E Hammer; Joseph L Goldstein; Michael S Brown
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
The Journal of biological chemistry 2002;277(11):9520-8.
2001: SD Rose; Galvin Swift; Michael Peyton; Robert E Hammer; Raymond J MacDonald
The role of PTF1-P48 in pancreatic acinar gene expression.
The Journal of biological chemistry 2001;276(47):44018-26.
2001: Jian Yang; Joseph L Goldstein; Robert E Hammer; Young-Ah Moon; Michael S Brown; Jay D Horton
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13607-12.
2001: Praveena Gupta; Abigail A Soyombo; A Atashband; Krystyna E Wisniewski; John M Shelton; James A Richardson; Robert E Hammer; Hofmann Sandra
Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13566-71.
2001: M Matsuda; BS Korn; Robert E Hammer; Young-Ah Moon; Ryutaro Komuro; Jay D Horton; Joseph L Goldstein; Michael S Brown; Iichiro Shimomura
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
Genes & development 2001;15(10):1206-16.
2001: Yaz Y Kisanuki; Robert E Hammer; J Miyazaki ; S Clay Williams; James A Richardson; Masashi Yanagisawa
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.
Developmental biology 2001;230(2):230-42.
2001: Narimon Honarpour; K Tabuchi; J M Stark; Robert E Hammer; Thomas C Südhof; Luis F Parada; Xinhe Wang; James A Richardson; Joachim Herz
Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.
Neuroscience 2001;106(2):263-74.
2000: Iichiro Shimomura; M Matsuda; Robert E Hammer; Yuriy Bashmakov; Michael S Brown; Joseph L Goldstein
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
Molecular cell 2000;6(1):77-86.
2000: Hiromi Yanagisawa; Robert E Hammer; James A Richardson; N Emoto; S Clay Williams; S i Takeda; David E Clouthier; Masashi Yanagisawa
Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development.
The Journal of clinical investigation 2000;105(10):1373-82.
2000: Narimon Honarpour; C Du; James A Richardson; Robert E Hammer; Xinhe Wang; Joachim Herz
Adult Apaf-1-deficient mice exhibit male infertility.
Developmental biology 2000;218(2):248-58.
2000: Matthijs Verhage; Ascanio S Maia; Jaap J Plomp; Arjen B Brussaard; Joost H Heeroma; HJ Vermeer; Ruud F G Toonen; Robert E Hammer; T K van den Berg; Markus Missler; Hans J Geuze; Thomas C Südhof
Synaptic assembly of the brain in the absence of neurotransmitter secretion.
Science (New York, N.Y.) 2000;287(5454):864-9.
2000: Shuyu Li; Robert E Hammer; Julia B George-Raizen; K C Meyers; William T Garrard
High-level rearrangement and transcription of yeast artificial chromosome-based mouse Ig kappa transgenes containing distal regions of the contig.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):812-24.
1999: Joel D Taurog; Robert E Hammer; J A Ricardson; Nimman Satumtira; CA Slaughter; Geoffrey W Butcher; Jonathan C Howard; LY Leong
Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B27-associated inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5741.
1999: Joel D Taurog; Robert E Hammer; Carolyn Moomaw; CA Slaughter; Derry C Roopenian; Aamir Zuberi; SJ Gaskell; RS Bordoli; Robert A Colbert; Geoffrey W Butcher; LY Leong
Novel HY peptide antigens presented by HLA-B27.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5741.
1999: Rafael Fernández-Chacón; Guillermo Alvarez de Toledo; Robert E Hammer; Thomas C Südhof
Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice.
The Journal of biological chemistry 1999;274(46):32551-4.
1999: Joel D Taurog; Kirsten Fischer Lindahl; Robert E Hammer; CA Slaughter; SD Maika; M Zhou; Derry C Roopenian; Gregory J Christianson; SJ Gaskell; RC Jones; RS Bordoli; Hidde L Ploegh; B Galocha; SG Summerfield
A new MHC locus that influences class I peptide presentation.
Immunity 1999;11(4):following 506.
1999: M Hosaka; Robert E Hammer; Thomas C Südhof
A phospho-switch controls the dynamic association of synapsins with synaptic vesicles.
Neuron 1999;24(2):377-87.
1999: Iichiro Shimomura; Robert E Hammer; Shinji Ikemoto; Michael S Brown; Joseph L Goldstein
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.
Nature 1999;401(6748):73-6.
1999: Richard M Chemelli; Jon T Willie; Christopher M Sinton; Joel K Elmquist; Thomas E Scammell; Charles Lee; James A Richardson; S Clay Williams; Y Xiong; Yaz Y Kisanuki; TE Fitch; M Nakazato; Robert E Hammer; Clifford B Saper; Masashi Yanagisawa
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
Cell 1999;98(4):437-51.
1999: Joseph L Alcorn; Robert E Hammer; K R Graves; M E Smith; SD Maika; Laura F Michael; Erwei Gao; Ying Wang; Carole R Mendelson
Analysis of genomic regions involved in regulation of the rabbit surfactant protein A gene in transgenic mice.
The American journal of physiology 1999;277(2 Pt 1):L349-61.
1999: M Trommsdorff; Michael Gotthardt; Thomas Hiesberger; John Shelton; Walter Stockinger; Johannes Nimpf; Robert E Hammer; James A Richardson; Joachim Herz
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Cell 1999;97(6):689-701.
1999: Joel D Taurog; SD Maika; Nimman Satumtira; Martha L Dorris; I L McLean; H Yanagisawa; Alain E Sayad; A J Stagg; G M Fox; A Lê O'Brien; M Rehman; M Zhou; A L Weiner; J B Splawski; James A Richardson; Robert E Hammer
Inflammatory disease in HLA-B27 transgenic rats.
Immunological reviews 1999;169():209-23.
1998: M Missler; Robert E Hammer; Thomas C Südhof
Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
The Journal of biological chemistry 1998;273(52):34716-23.
1998: BS Korn; Iichiro Shimomura; Yuriy Bashmakov; Robert E Hammer; Jay D Horton; Joseph L Goldstein; Michael S Brown
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
The Journal of clinical investigation 1998;102(12):2050-60.
1998: H Tian; Robert E Hammer; A M Matsumoto; David W Russell; Steven L McKnight
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development.
Genes & development 1998;12(21):3320-4.
1998: Iichiro Shimomura; Robert E Hammer; James A Richardson; Shinji Ikemoto; Yuriy Bashmakov; Joseph L Goldstein; Michael S Brown
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.
Genes & development 1998;12(20):3182-94.
1998: Shuyu Li; Julia B George-Raizen; Robert E Hammer; William T Garrard
Accurate quantification of expression of transgenes marked with restriction endonuclease site polymorphisms by RT-PCR.
BioTechniques 1998;25(4):558-60, 562.
1998: Cheryl Gariepy; S Clay Williams; James A Richardson; Robert E Hammer; Masashi Yanagisawa
Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease.
The Journal of clinical investigation 1998;102(6):1092-101.
1998: M Zhou; Alain E Sayad; WA Simmons; RC Jones; SD Maika; Nimman Satumtira; Martha L Dorris; SJ Gaskell; RS Bordoli; Ryan Sartor; CA Slaughter; James A Richardson; Robert E Hammer; Joel D Taurog
The specificity of peptides bound to human histocompatibility leukocyte antigen (HLA)-B27 influences the prevalence of arthritis in HLA-B27 transgenic rats.
The Journal of experimental medicine 1998;188(5):877-86.
1998: Hiromi Yanagisawa; Robert E Hammer; James A Richardson; S Clay Williams; David E Clouthier; Masashi Yanagisawa
Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice.
The Journal of clinical investigation 1998;102(1):22-33.
1998: Jay D Horton; Iichiro Shimomura; Michael S Brown; Robert E Hammer; Joseph L Goldstein; H Shimano
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
The Journal of clinical investigation 1998;101(11):2331-9.
1998: DJ Peet; Stephen D Turley; W Ma; Bethany A Janowski; Jean-Marc Lobaccaro; Robert E Hammer; David J Mangelsdorf
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.
Cell 1998;93(5):693-704.
1998: Hiromi Yanagisawa; Masashi Yanagisawa; R P Kapur; James A Richardson; S Clay Williams; David E Clouthier; D de Wit; N Emoto; Robert E Hammer
Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene.
Development (Cambridge, England) 1998;125(5):825-36.
1998: David E Clouthier; K Hosoda; James A Richardson; S Clay Williams; Hiromi Yanagisawa; T Kuwaki; M Kumada; Robert E Hammer; Masashi Yanagisawa
Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice.
Development (Cambridge, England) 1998;125(5):813-24.
1998: A Rohlmann; Michael Gotthardt; Robert E Hammer; Joachim Herz
Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
The Journal of clinical investigation 1998;101(3):689-95.
1998: Martin Geppert; Mikhail Khvotchev; Valery Krasnoperov; Y Goda; Markus Missler; Robert E Hammer; Konstantin Ichtchenko; Alexander G Petrenko; Thomas C Südhof
Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.
The Journal of biological chemistry 1998;273(3):1705-10.
1997: E Kroon; Raymond J MacDonald; Robert E Hammer
The transcriptional regulatory strategy of the rat tissue kallikrein gene family.
Genes and function 1997;1(5-6):309-19.
1997: David E Clouthier; S A Comerford; Robert E Hammer
Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.
The Journal of clinical investigation 1997;100(11):2697-713.
1997: WA Simmons; Derry C Roopenian; SG Summerfield; RC Jones; B Galocha; Gregory J Christianson; SD Maika; M Zhou; SJ Gaskell; RS Bordoli; Hidde L Ploegh; CA Slaughter; Kirsten Fischer Lindahl; Robert E Hammer; Joel D Taurog
A new MHC locus that influences class I peptide presentation.
Immunity 1997;7(5):641-51.
1997: H Shimano; Iichiro Shimomura; Robert E Hammer; Joachim Herz; Joseph L Goldstein; Michael S Brown; Jay D Horton
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
The Journal of clinical investigation 1997;100(8):2115-24.
1997: WA Simmons; SG Summerfield; Derry C Roopenian; CA Slaughter; Aamir Zuberi; SJ Gaskell; RS Bordoli; J Hoyes; Carolyn Moomaw; Robert A Colbert; LY Leong; Geoffrey W Butcher; Robert E Hammer; Joel D Taurog
Novel HY peptide antigens presented by HLA-B27.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2750-9.
1997: H Shimano; Jay D Horton; Iichiro Shimomura; Robert E Hammer; Michael S Brown; Joseph L Goldstein
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
The Journal of clinical investigation 1997;99(5):846-54.
1996: David L Cheo; Lisiane Meira; Robert E Hammer; Dennis K Burns; A T Doughty; Errol C Friedberg
Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer.
Current biology : CB 1996;6(12):1691-4.
1996: A Rohlmann; Michael Gotthardt; Thomas E Willnow; Robert E Hammer; Joachim Herz
Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Nature biotechnology 1996;14(11):1562-5.
1996: H Shimano; Jay D Horton; Robert E Hammer; Iichiro Shimomura; Michael S Brown; Joseph L Goldstein
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
The Journal of clinical investigation 1996;98(7):1575-84.
1996: Thomas E Willnow; Jan Hilpert; Scott A Armstrong; A Rohlmann; Robert E Hammer; DK Burns; Joachim Herz
Defective forebrain development in mice lacking gp330/megalin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8460-4.
1996: Thomas E Willnow; A Rohlmann; J Horton; H Otani; J R Braun; Robert E Hammer; Joachim Herz
RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.
The EMBO journal 1996;15(11):2632-9.
1996: D E Clouthier; Mary R Avarbock; S D Maika; Robert E Hammer; Ralph L Brinster
Rat spermatogenesis in mouse testis.
Nature 1996;381(6581):418-21.
1996: H T McMahon; Vadim Y Bolshakov; R Janz; Robert E Hammer; Steven A Siegelbaum; Thomas C Südhof
Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4760-4.
1996: W A Simmons; LY Leong; Nimman Satumtira; Geoffrey W Butcher; J C Howard; James A Richardson; C A Slaughter; Robert E Hammer; Joel D Taurog
Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B27-associated inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1661-7.
1996: M Breban; J L Fernández-Sueiro; James A Richardson; R R Hadavand; SD Maika; Robert E Hammer; Joel D Taurog
T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):794-803.
1996: Joel D Taurog; Robert E Hammer
Experimental spondyloarthropathy in HLA-B27 transgenic rats.
Clinical rheumatology 1996;15 Suppl 1():22-7.
1995: F P Mancini; D L Newland; Vincent Mooser; J Murata; Santica Marcovina; Stephen G Young; Robert E Hammer; David A Sanan; Helen H Hobbs
Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):1911-6.
1995: H Yanagisawa; James A Richardson; Joel D Taurog; Robert E Hammer
Characterization of psoriasiform and alopecic skin lesions in HLA-B27 transgenic rats.
The American journal of pathology 1995;147(4):955-64.
1995: F Kruse; SD Rose; Galvin Swift; Robert E Hammer; Raymond J MacDonald
Cooperation between elements of an organ-specific transcriptional enhancer in animals.
Molecular and cellular biology 1995;15(8):4385-94.
1995: T W Rosahl; D Spillane; Markus Missler; Joachim Herz; D K Selig; J R Wolff; Robert E Hammer; Robert C Malenka; Thomas C Südhof
Essential functions of synapsins I and II in synaptic vesicle regulation.
Nature 1995;375(6531):488-93.
1995: Robert E Hammer; James A Richardson; W A Simmons; AL White; M Breban; Joel D Taurog
High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1995;43(3):262-8.
1995: Thomas E Willnow; Scott A Armstrong; Robert E Hammer; Joachim Herz
Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4537-41.
1995: S A Comerford; SD Maika; Laimonis A Laimins; Albee Messing; H P Elsässer; Robert E Hammer
E6 and E7 expression from the HPV 18 LCR: development of genital hyperplasia and neoplasia in transgenic mice.
Oncogene 1995;10(3):587-97.
1995: A J Stagg; M Breban; Robert E Hammer; S C Knight; Joel D Taurog
Defective dendritic cell (DC) function in a HLA-B27 transgenic rat model of spondyloarthropathy (SpA).
Advances in experimental medicine and biology 1995;378():557-9.
1994: A G Baynash; K Hosoda; Adel Giaid; James A Richardson; N Emoto; Robert E Hammer; Masashi Yanagisawa
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.
Cell 1994;79(7):1277-85.
1994: K Hosoda; Robert E Hammer; James A Richardson; A G Baynash; J C Cheung; Adel Giaid; Masashi Yanagisawa
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.
Cell 1994;79(7):1267-76.
1994: Joel D Taurog; James A Richardson; J T Croft; W A Simmons; M Zhou; J L Fernández-Sueiro; Edward Balish; Robert E Hammer
The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.
The Journal of experimental medicine 1994;180(6):2359-64.
1994: Martin Geppert; Y Goda; Robert E Hammer; C Li; T W Rosahl; C F Stevens; Thomas C Südhof
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.
Cell 1994;79(4):717-27.
1994: S Ishibashi; Robert E Hammer; Joachim Herz
Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit.
The Journal of biological chemistry 1994;269(45):27803-6.
1994: Martin Geppert; B Ullrich; Daniel G Green; K Takei; L Daniels; Pietro De Camilli; Thomas C Südhof; Robert E Hammer
Synaptic targeting domains of synapsin I revealed by transgenic expression in photoreceptor cells.
The EMBO journal 1994;13(16):3720-7.
1994: Martin Geppert; Vadim Y Bolshakov; Steven A Siegelbaum; K Takei; Pietro De Camilli; Robert E Hammer; Thomas C Südhof
The role of Rab3A in neurotransmitter release.
Nature 1994;369(6480):493-7.
1994: SD Rose; F Kruse; Galvin Swift; Raymond J MacDonald; Robert E Hammer
A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut.
Molecular and cellular biology 1994;14(3):2048-57.
1993: T W Rosahl; Martin Geppert; D Spillane; Joachim Herz; Robert E Hammer; Robert C Malenka; Thomas C Südhof
Short-term synaptic plasticity is altered in mice lacking synapsin I.
Cell 1993;75(4):661-70.
1993: M Breban; Robert E Hammer; James A Richardson; Joel D Taurog
Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment.
The Journal of experimental medicine 1993;178(5):1607-16.
1993: S Ishibashi; Michael S Brown; Joseph L Goldstein; Robert D Gerard; Robert E Hammer; Joachim Herz
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.
The Journal of clinical investigation 1993;92(2):883-93.
1993: Joel D Taurog; SD Maika; W A Simmons; M Breban; Robert E Hammer
Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):4168-78.
1993: F Kruse; SD Rose; Galvin Swift; Robert E Hammer; Raymond J MacDonald
An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer.
Genes & development 1993;7(5):774-86.
1993: M A Breban; Robert E Hammer; J D Taurog
[Transgenic rats for HLA-B27 and human beta 2 microglobulin: a model of spondyloarthritis].
Revue du rhumatisme (Ed. française : 1993) 1993;60(3):181-6.
1993: W A Simmons; Joel D Taurog; Robert E Hammer; M Breban
Sharing of an HLA-B27-restricted H-Y antigen between rat and mouse.
Immunogenetics 1993;38(5):351-8.
1992: B P Davis; Robert E Hammer; Albee Messing; Raymond J MacDonald
Selective expression of trypsin fusion genes in acinar cells of the pancreas and stomach of transgenic mice.
The Journal of biological chemistry 1992;267(36):26070-7.
1992: G Chiesa; Helen H Hobbs; M L Koschinsky; R M Lawn; SD Maika; Robert E Hammer
Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a).
The Journal of biological chemistry 1992;267(34):24369-74.
1992: E G Beale; David E Clouthier; Robert E Hammer
Cell-specific expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(15):3330-7.
1992: Joachim Herz; David E Clouthier; Robert E Hammer
LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.
Cell 1992;71(3):411-21.
1992: M S Smith; J Lechago; D R Wines; Raymond J MacDonald; Robert E Hammer
Tissue-specific expression of kallikrein family transgenes in mice and rats.
DNA and cell biology 1992;11(5):345-58.
1992: M Yokode; R K Pathak; Robert E Hammer; Michael S Brown; Joseph L Goldstein; Richard G W Anderson
Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice.
The Journal of cell biology 1992;117(1):39-46.
1992: M K Short; David E Clouthier; I M Schaefer; Robert E Hammer; Mark Magnuson; E G Beale
Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.
Molecular and cellular biology 1992;12(3):1007-20.
1991: Carla J Aldrich; Robert E Hammer; S Jones-Youngblood; U Koszinowski; Leroy Hood; Iwona Stroynowski; James Forman
Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the alpha 3 domain of MHC I molecules.
Nature 1991;352(6337):718-21.
1991: J Forman; K Wieties; Robert E Hammer
Tolerance to liver-specific antigens.
Immunological reviews 1991;122():33-46.
1990: Robert E Hammer; SD Maika; James A Richardson; J P Tang; Joel D Taurog
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders.
Cell 1990;63(5):1099-112.
1990: M Yokode; Robert E Hammer; S Ishibashi; Michael S Brown; Joseph L Goldstein
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.
Science (New York, N.Y.) 1990;250(4985):1273-5.
1990: K Wieties; Robert E Hammer; S Jones-Youngblood; James Forman
Peripheral tolerance in mice expressing a liver-specific class I molecule: inactivation/deletion of a T-cell subpopulation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6604-8.
1990: R K Pathak; M Yokode; Robert E Hammer; Hofmann Sandra; Michael S Brown; Joseph L Goldstein; Richard G W Anderson
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice.
The Journal of cell biology 1990;111(2):347-59.
1990: L M Roman; L F Simons; Robert E Hammer; J F Sambrook; Mary-Jane Gething
The expression of influenza virus hemagglutinin in the pancreatic beta cells of transgenic mice results in autoimmune diabetes.
Cell 1990;61(3):383-96.
1990: Hofmann Sandra; D L Eaton; Michael S Brown; W J McConathy; Joseph L Goldstein; Robert E Hammer
Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.
The Journal of clinical investigation 1990;85(5):1542-7.
1990: S L Jones-Youngblood; K Wieties; James Forman; Robert E Hammer
Effect of the expression of a hepatocyte-specific MHC molecule in transgenic mice on T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1187-95.
1989: M Xu; Robert E Hammer; V C Blasquez; S L Jones; William T Garrard
Immunoglobulin kappa gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice.
The Journal of biological chemistry 1989;264(35):21190-5.
1989: Galvin Swift; F Kruse; Raymond J MacDonald; Robert E Hammer
Differential requirements for cell-specific elastase I enhancer domains in transfected cells and transgenic mice.
Genes & development 1989;3(5):687-96.
1989: C J Quaife; L S Mathews; C A Pinkert; Robert E Hammer; Ralph L Brinster; Richard D Palmiter
Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice.
Endocrinology 1989;124(1):40-8.
1988: Joel D Taurog; J P Durand; F A el-Zaatari; Robert E Hammer
Studies of HLA-B27-associated disease.
The American journal of medicine 1988;85(6A):59-60.
1988: L S Mathews; Robert E Hammer; R R Behringer; Augustine D'ercole; G I Bell; Ralph L Brinster; Richard D Palmiter
Growth enhancement of transgenic mice expressing human insulin-like growth factor I.
Endocrinology 1988;123(6):2827-33.
1988: Joel D Taurog; L Lowen; J Forman; Robert E Hammer
HLA-B27 in inbred and non-inbred transgenic mice. Cell surface expression and recognition as an alloantigen in the absence of human beta 2-microglobulin.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):4020-3.
1988: L S Mathews; Robert E Hammer; Ralph L Brinster; Richard D Palmiter
Expression of insulin-like growth factor I in transgenic mice with elevated levels of growth hormone is correlated with growth.
Endocrinology 1988;123(1):433-7.
1988: Hofmann Sandra; David W Russell; Michael S Brown; Joseph L Goldstein; Robert E Hammer
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.
Science (New York, N.Y.) 1988;239(4845):1277-81.
1987: D M Ornitz; Robert E Hammer; Albee Messing; Richard D Palmiter; Ralph L Brinster
Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice.
Science (New York, N.Y.) 1987;238(4824):188-93.
1987: D M Ornitz; Robert E Hammer; B L Davison; Ralph L Brinster; Richard D Palmiter
Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers.
Molecular and cellular biology 1987;7(10):3466-72.
1987: R R Behringer; Robert E Hammer; Ralph L Brinster; Richard D Palmiter; Tim M Townes
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7056-60.
1987: Robert E Hammer; Galvin Swift; D M Ornitz; C J Quaife; Richard D Palmiter; Ralph L Brinster; Raymond J MacDonald
The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.
Molecular and cellular biology 1987;7(8):2956-67.
1987: Raymond J MacDonald; Galvin Swift; Robert E Hammer; D M Ornitz; B P Davis; Ralph L Brinster; Richard D Palmiter
Targeted expression of cloned genes in transgenic mice.
Progress in brain research 1987;71():3-12.
1986: Raymond J MacDonald; Robert E Hammer; Galvin Swift; B P Davis; Ralph L Brinster
Transgenic progeny inherit tissue-specific expression of rat elastase I genes.
DNA (Mary Ann Liebert, Inc.) 1986;5(5):393-401.
1986: Raymond J MacDonald; Robert E Hammer; Galvin Swift; D M Ornitz; B P Davis; Richard D Palmiter; Ralph L Brinster
Tissue-specific expression of pancreatic genes in transgenic mice.
Annals of the New York Academy of Sciences 1986;478():131-46.
1985: D M Ornitz; Richard D Palmiter; Robert E Hammer; Ralph L Brinster; Galvin Swift; Raymond J MacDonald
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice.
Nature 1985;313(6003):600-2.
1985: D M Ornitz; Richard D Palmiter; Albee Messing; Robert E Hammer; C A Pinkert; Ralph L Brinster
Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice.
Cold Spring Harbor symposia on quantitative biology 1985;50():399-409.
1984: Galvin Swift; Robert E Hammer; Raymond J MacDonald; Ralph L Brinster
Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice.
Cell 1984;38(3):639-46.