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Milton Hammond

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Helen Chen; Paula Fitzgerald; Nichelle Hairston; Timothy A Blizzard; Jeffrey Donald Hermes; Seongkon Kim; Jun Lu; Aimie M Ogawa; Ronald E Painter; Young-Whan Park; Susan Raghoobar; Giovanna Scapin; Nandini Sharma; Douglas Wisniewski; Jane Wu; Katherine Young; Milton L Hammond
Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.
Qiang Tan; Douglas Wisniewski; Katherine Young; Lawrence F Colwell; Frank DiNinno; Jeffrey Donald Hermes; Aimie M Ogawa; Young-Whan Park; Susan L Raghoobar; Milton L Hammond
Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.
Cameron J Smith; Carl P Sparrow; Gayle E Taylor; Christopher F Thompson; Xinchun Tong; Samuel D Wright; Suoyu S Xu; Amjad Ali; Matt S Anderson; Y Chen; Anne Marie Cumiskey; Suzanne S Eveland; Qiu Guo; Milton L Hammond; Sheryl A Hyland; Melanie Latham; Hong Li; Zhijian Lu; Denise P Milot; Joann Napolitano; Laurence B Peterson; James V Pivnichny; R Rosa; Peter J Sinclair
Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.

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All Publications

2011: Helen Chen; Paula Fitzgerald; Nichelle Hairston; Timothy A Blizzard; Jeffrey Donald Hermes; Seongkon Kim; Jun Lu; Aimie M Ogawa; Ronald E Painter; Young-Whan Park; Susan Raghoobar; Giovanna Scapin; Nandini Sharma; Douglas Wisniewski; Jane Wu; Katherine Young; Milton L Hammond
Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.
Bioorganic & medicinal chemistry letters 2011;21(14):4267-70.
2011: Qiang Tan; Douglas Wisniewski; Katherine Young; Lawrence F Colwell; Frank DiNinno; Jeffrey Donald Hermes; Aimie M Ogawa; Young-Whan Park; Susan L Raghoobar; Milton L Hammond
Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.
Bioorganic & medicinal chemistry letters 2011;21(14):4363-5.
2011: Cameron J Smith; Carl P Sparrow; Gayle E Taylor; Christopher F Thompson; Xinchun Tong; Samuel D Wright; Suoyu S Xu; Amjad Ali; Matt S Anderson; Y Chen; Anne Marie Cumiskey; Suzanne S Eveland; Qiu Guo; Milton L Hammond; Sheryl A Hyland; Melanie Latham; Hong Li; Zhijian Lu; Denise P Milot; Joann Napolitano; Laurence B Peterson; James V Pivnichny; R Rosa; Peter J Sinclair
Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.
Journal of medicinal chemistry 2011;54(13):4880-95.
2011: Ramzi F Sweis; Julianne A Hunt; Florida Kallashi; Milton L Hammond; Y Chen; Suzanne S Eveland; Qiu Guo; Sheryl A Hyland; Denise P Milot; Anne-Marie Cumiskey; Melanie Latham; R Rosa; Larry Peterson; Carl P Sparrow; Samuel D Wright; Matt S Anderson; Peter J Sinclair
2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.
Bioorganic & medicinal chemistry letters 2011;21(6):1890-5.
2011: Florida Kallashi; Dooseop Kim; Jennifer Kowalchick; You Jung Park; Julianne A Hunt; Amjad Ali; Cameron J Smith; Milton L Hammond; James V Pivnichny; Xinchun Tong; Suoyu S Xu; Matt S Anderson; Y Chen; Suzanne S Eveland; Qiu Guo; Sheryl A Hyland; Denise P Milot; Anne Marie Cumiskey; Melanie Latham; Laurence B Peterson; R Rosa; Carl P Sparrow; Samuel D Wright; Peter J Sinclair
2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.
Bioorganic & medicinal chemistry letters 2011;21(1):558-61.
2010: Zhijian Lu; Joann B Napolitano; Ashleigh Theberge; Amjad Ali; Milton L Hammond; Eugene Tan; Xinchun Tong; Suoyu S Xu; Melanie J Latham; Laurence B Peterson; Matt S Anderson; Suzanne S Eveland; Qiu Guo; Sheryl A Hyland; Denise P Milot; Y Chen; Carl P Sparrow; Samuel D Wright; Peter J Sinclair
Design of a novel class of biphenyl CETP inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(24):7469-72.
2010: Fa-Xiang Ding; Hong Shen; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ning Ren; Tian-Quan Cai; Junying Wang; Xinchun Tong; Tom Holt; Qing Chen; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.
Bioorganic & medicinal chemistry letters 2010;20(11):3372-5.
2010: Timothy A Blizzard; Helen Chen; Seongkon Kim; Jane Wu; Katherine Young; Young-Whan Park; Amy Ogawa; Susan Raghoobar; Ronald E Painter; Nichelle Hairston; Sang Ho Lee; Andrew Misura; Tom Felcetto; Paula Fitzgerald; Nandini Sharma; Jun Lu; Sookhee Ha; Emily Hickey; Jeff Hermes; Milton L Hammond
Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.
Bioorganic & medicinal chemistry letters 2010;20(3):918-21.
2010: Julianne A Hunt; Silvia Gonzalez; Florida Kallashi; Milton L Hammond; James V Pivnichny; Xinchun Tong; Suoyu S Xu; Matt S Anderson; Y Chen; Suzanne S Eveland; Qiu Guo; Sheryl A Hyland; Denise P Milot; Carl P Sparrow; Samuel D Wright; Peter J Sinclair
2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety.
Bioorganic & medicinal chemistry letters 2010;20(3):1019-22.
2010: Cameron J Smith; Amjad Ali; Liya Chen; Milton L Hammond; Matt S Anderson; Y Chen; Suzanne S Eveland; Qiu Guo; Sheryl A Hyland; Denise P Milot; Carl P Sparrow; Samuel D Wright; Peter J Sinclair
2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.
Bioorganic & medicinal chemistry letters 2010;20(1):346-9.
2009: Hong Shen; Fa-Xiang Ding; Qiaolin Deng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ester Carballo-Jane; Ning Ren; Tian-Quan Cai; Tsuei-Ju Wu; Kenneth K Wu; Kang Cheng; Qing Chen; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Journal of medicinal chemistry 2009;52(8):2587-602.
2009: Hong Shen; Fa-Xiang Ding; Sheo B Singh; Gopalakrishnan Parthasarathy; Stephen M Soisson; Sookhee N Ha; Xun Chen; Srinivas Kodali; Jun Wang; Karen Dorso; James R Tata; Milton L Hammond; Malcolm MacCoss; Steven L Colletti
Synthesis and biological evaluation of platensimycin analogs.
Bioorganic & medicinal chemistry letters 2009;19(6):1623-7.
2008: Hong Shen; Andrew K P Taggart; Larissa C Wilsie; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A.
Bioorganic & medicinal chemistry letters 2008;18(18):4948-51.
2008: Amjad Ali; James M Balkovec; Mark Greenlee; Milton L Hammond; Greg Rouen; Gayle Taylor; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Michael J Forrest; Ester Carballo-Jane; Silvi Luell; Karen Lowitz; Denise visco
Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.
Bioorganic & medicinal chemistry 2008;16(16):7535-42.
2008: Angela Scafonas; Alfred A Reszka; Donald B Kimmel; Xiaoli Shirley Hou; Qin Su; Elizabeth T Birzin; Seongkon Kim; Helen Y Chen; Qiang Tan; Susan P Roher; Frank DiNinno; Milton L Hammond; Gideon A Rodan; Dwight A Towler; Azriel Schmidt
Agonist-like SERM effects on ERalpha-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus.
The Journal of steroid biochemistry and molecular biology 2008;110(3-5):197-206.
2008: Subharekha Raghavan; G Scott Tria; Hong Shen; Fa-Xiang Ding; Andrew K P Taggart; Ning Ren; Larissa C Wilsie; Mihajlo L Krsmanovic; Tom Holt; Michael S Wolff; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists.
Bioorganic & medicinal chemistry letters 2008;18(11):3163-7.
2007: Hong Shen; Michael J Szymonifka; Divya Kharbanda; Qiaolin Deng; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Junying Wang; Xinchun Tong; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.
Bioorganic & medicinal chemistry letters 2007;17(24):6723-8.
2007: Hong Shen; Fa-Xiang Ding; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K Taggart; Ning Ren; Tian-Quan Cai; Qiaolin Deng; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Journal of medicinal chemistry 2007;50(25):6303-6.
2007: Timothy A Blizzard; Candido Gude; Jerry D Morgan; Wanda Chan; Elizabeth T Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Ralph T Mosley; Mark A Holmes; Susan P Rohrer; Milton L Hammond
Androstene-3,5-dienes as ER-beta selective SERMs.
Bioorganic & medicinal chemistry letters 2007;17(22):6295-8.
2007: Christopher F Thompson; Nazia Quraishi; Amjad Ali; Ralph T Mosley; James R Tata; Milton L Hammond; James M Balkovec; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Douglas Miller; Ting-ting D Yamin; Chris Thompson; Edward A O'Neill; Dennis Zaller; Michael J Forrest; Ester Carballo-Jane; Silvi Luell
Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.
Bioorganic & medicinal chemistry letters 2007;17(12):3354-61.
2007: Timothy A Blizzard; Candido Gude; Wanda Chan; Elizabeth T Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Mark A Holmes; Susan P Rohrer; Milton L Hammond
Bridged androstenediol analogs as ER-beta selective SERMs.
Bioorganic & medicinal chemistry letters 2007;17(10):2944-8.
2007: Kevin D Dykstra; Liangqin Guo; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Edward C Hayes; Carolyn A DaSilva; Lee-Yuh Pai; Ralph T Mosley; Bryan Kraker; Paula M D Fitzgerald; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.
Bioorganic & medicinal chemistry letters 2007;17(8):2322-8.
2006: Kenneth J Wildonger; Ronald W Ratcliffe; Ralph T Mosley; Milton L Hammond; Elizabeth T Birzin; Susan P Rohrer
Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.
Bioorganic & medicinal chemistry letters 2006;16(17):4462-6.
2006: Dann L Parker; Dongfang Meng; Ronald W Ratcliffe; Robert R Wilkening; Donald M Sperbeck; Mark L Greenlee; Lawrence F Colwell; Sherrie Lambert; Elizabeth T Birzin; Katalin Frisch; Susan P Rohrer; Stefan Nilsson; Ann-Gerd Thorsell; Milton L Hammond
Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists.
Bioorganic & medicinal chemistry letters 2006;16(17):4652-6.
2006: Robert R Wilkening; Ronald W Ratcliffe; A K Fried; D Meng; W Sun; Lawrence F Colwell; S Lambert; Mark L Greenlee; Stefan Nilsson; Ann-Gerd Thorsell; Marina Mojena; Consuelo Tudela; Katalin Frisch; Wanda Chan; Elizabeth T Birzin; Susan P Rohrer; Milton L Hammond
Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere.
Bioorganic & medicinal chemistry letters 2006;16(15):3896-901.
2006: Robert R Wilkening; Ronald W Ratcliffe; E C Tynebor; Kenneth J Wildonger; A K Fried; Milton L Hammond; Ralph T Mosley; Paula M D Fitzgerald; Nandini Sharma; Brian McKeever; Stefan Nilsson; M Carlquist; Ann-Gerd Thorsell; Louis Locco; R Katz; Katalin Frisch; Elizabeth T Birzin; Hilary A Wilkinson; S Mitra; S Cai; Edward C Hayes; James M Schaeffer; Susan P Rohrer
The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.
Bioorganic & medicinal chemistry letters 2006;16(13):3489-94.
2006: Wanying Sun; Lovji D Cama; Elizabeth T Birzin; Sudha Warrier; Louis Locco; Ralph T Mosley; Milton L Hammond; Susan P Rohrer
6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.
Bioorganic & medicinal chemistry letters 2006;16(6):1468-72.
2006: Lorraine Lipfert; John E Fisher; Nan Wei; Angela Scafonas; Qin Su; Joel B Yudkovitz; Fang Chen; Sudha Warrier; Elizabeth T Birzin; Seongkon Kim; Helen Y Chen; Qiang Tan; Azriel Schmidt; Frank DiNinno; Susan P Rohrer; Milton L Hammond; Gideon A Rodan; Leonard P Freedman; Alfred A Reszka
Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.
Molecular endocrinology (Baltimore, Md.) 2006;20(3):516-33.
2006: Timothy A Blizzard; Candido Gude; Jerry D Morgan; Wanda Chan; Elizabeth T Birzin; Marina Mojena; Consuelo Tudela; Fang Chen; Kristin Knecht; Qin Su; Bryan Kraker; Ralph T Mosley; Mark A Holmes; Nandini Sharma; Paula M D Fitzgerald; Susan P Rohrer; Milton L Hammond
Androstenediol analogs as ER-beta-selective SERMs.
Bioorganic & medicinal chemistry letters 2006;16(4):834-8.
2005: Timothy A Blizzard; Jerry D Morgan; Wanda Chan; Elizabeth T Birzin; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Ralph T Mosley; Yi Tien Yang; Susan P Rohrer; Frank DiNinno; Milton L Hammond
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
Bioorganic & medicinal chemistry letters 2005;15(23):5124-8.
2005: Timothy A Blizzard; Frank DiNinno; Helen Y Chen; Seongkon Kim; Jane Y Wu; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain.
Bioorganic & medicinal chemistry letters 2005;15(17):3912-6.
2005: Cameron J Smith; Amjad Ali; James M Balkovec; Donald W Graham; Milton L Hammond; Gool F Patel; Gregory P Rouen; Scott K Smith; James R Tata; Monica Einstein; Lan Ge; Georgianna S Harris; Theresa M Kelly; Paul Mazur; Chris Thompson; Chuanlin F Wang; Joanne M Williamson; Douglas Miller; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Ting-ting D Yamin; Edward A O'Neill; Dennis Zaller; Ester Carballo-Jane; Michael J Forrest; Silvi Luell
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.
Bioorganic & medicinal chemistry letters 2005;15(11):2926-31.
2005: Christopher F Thompson; Nazia Quraishi; Amjad Ali; James R Tata; Milton L Hammond; James M Balkovec; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Douglas Miller; Ting-ting D Yamin; Chris Thompson; Edward A O'Neill; Dennis Zaller; Michael J Forrest; Ester Carballo-Jane; Silvi Luell
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Bioorganic & medicinal chemistry letters 2005;15(8):2163-7.
2005: Zhoupeng Zhang; Qing Chen; Ying Li; George A Doss; Brian J Dean; Jason S Ngui; Maria V Silva Elipe; Seongkon Kim; Jane Y Wu; Frank DiNinno; Milton L Hammond; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.
Chemical research in toxicology 2005;18(4):675-85.
2005: Qiang Tan; Timothy A Blizzard; Jerry D Morgan; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Sudha Warrier; Joel B Yudkovitz; Hilary A Wilkinson; Nandini Sharma; Paula M D Fitzgerald; Susan Li; Lawrence F Colwell; John E Fisher; Sharon Adamski; Alfred A Reszka; Donald B Kimmel; Frank DiNinno; Susan P Rohrer; Leonard P Freedman; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Bioorganic & medicinal chemistry letters 2005;15(6):1675-81.
2005: Seongkon Kim; Jane Y Wu; Zhoupeng Zhang; Wei Tang; George A Doss; Brian J Dean; Frank DiNinno; Milton L Hammond
Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis.
Organic letters 2005;7(3):411-4.
2005: Jian Liu; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Carolyn A DaSilva; Edward C Hayes; Ralph T Mosley; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.
Bioorganic & medicinal chemistry letters 2005;15(3):715-8.
2005: Timothy A Blizzard; Frank DiNinno; Jerry D Morgan; Helen Y Chen; Jane Y Wu; Seongkon Kim; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Paula M D Fitzgerald; Nandini Sharma; Ying Li; Zhoupeng Zhang; Edward C Hayes; Carolyn A DaSilva; Wei Tang; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorganic & medicinal chemistry letters 2005;15(1):107-13.
2004: Timothy A Blizzard; Frank DiNinno; Jerry D Morgan; Jane Y Wu; Helen Y Chen; Seongkon Kim; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Zhoupeng Zhang; Edward C Hayes; Carolyn A DaSilva; Wei Tang; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.
Bioorganic & medicinal chemistry letters 2004;14(15):3865-8.
2004: Timothy A Blizzard; Frank DiNinno; Jerry D Morgan; Helen Y Chen; Jane Y Wu; Candido Gude; Seongkon Kim; Wanda Chan; Elizabeth T Birzin; Yi Tien Yang; Lee-Yuh Pai; Zhoupeng Zhang; Edward C Hayes; Carolyn A DaSilva; Wei Tang; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.
Bioorganic & medicinal chemistry letters 2004;14(15):3861-4.
2004: Qiang Tan; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.
Bioorganic & medicinal chemistry letters 2004;14(14):3753-5.
2004: Qiang Tan; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Edward C Hayes; Carolyn A DaSilva; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains.
Bioorganic & medicinal chemistry letters 2004;14(14):3747-51.
2004: Seongkon Kim; Jane Wu; Helen Y Chen; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Lawrence F Colwell; Susan Li; Johanna Dahllund; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.
Bioorganic & medicinal chemistry letters 2004;14(11):2741-5.
2004: Milton L Hammond
Ertapenem: a Group 1 carbapenem with distinct antibacterial and pharmacological properties.
The Journal of antimicrobial chemotherapy 2004;53 Suppl 2():ii7-9.
2004: Helen Y Chen; Seongkon Kim; Jane Y Wu; Elizabeth T Birzin; Wanda Chan; Yi Tien Yang; Johanna Dahllund; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.
Bioorganic & medicinal chemistry letters 2004;14(10):2551-4.
2004: Amjad Ali; Christopher F Thompson; James M Balkovec; Donald W Graham; Milton L Hammond; Nazia Quraishi; James R Tata; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph C Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Douglas Miller; Chris Thompson; Dennis Zaller; Michael J Forrest; Ester Carballo-Jane; Silvi Luell
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Journal of medicinal chemistry 2004;47(10):2441-52.
2004: Seongkon Kim; Jane Y Wu; Elizabeth T Birzin; Katalin Frisch; Wanda Chan; Lee-Yuh Pai; Yi Tien Yang; Ralph T Mosley; Paula M D Fitzgerald; Nandini Sharma; Johanna Dahllund; Ann-Gerd Thorsell; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.
Journal of medicinal chemistry 2004;47(9):2171-5.
2004: Helen Y Chen; Kevin D Dykstra; Elizabeth T Birzin; Katalin Frisch; Wanda Chan; Yi Tien Yang; Ralph T Mosley; Frank DiNinno; Susan P Rohrer; James M Schaeffer; Milton L Hammond
Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.
Bioorganic & medicinal chemistry letters 2004;14(6):1417-21.
2004: Timothy A Blizzard; Ralph T Mosley; Elizabeth T Birzin; Wanda Chan; Milton L Hammond
Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!
Bioorganic & medicinal chemistry letters 2004;14(5):1317-21.
2003: Timothy A Blizzard; Jerry D Morgan; Ralph T Mosley; Elizabeth T Birzin; Katalin Frisch; Susan P Rohrer; Milton L Hammond
2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).
Bioorganic & medicinal chemistry letters 2003;13(3):479-83.
2002: Qing Chen; Jason S Ngui; George A Doss; Regina W Wang; Xiaoxin Cai; Frank DiNinno; Timothy A Blizzard; Milton L Hammond; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Chemical research in toxicology 2002;15(7):907-14.
2002: Timothy A Blizzard; Ronald M Kim; Jerry D Morgan; Jiang Chang; Joyce Kohler; Ruth Kilburn; Kevin Chapman; Milton L Hammond
Antibacterial activity of G6-quaternary ammonium derivatives of a lipophilic vancomycin analogue.
Bioorganic & medicinal chemistry letters 2002;12(6):849-52.
2001: Jeffrey Toney; GG Hammond; Paula M D Fitzgerald; N Sharma; James M Balkovec; Gregory P Rouen; Steven H Olson; Milton L Hammond; Mark L Greenlee; Y D Gao
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase.
The Journal of biological chemistry 2001;276(34):31913-8.
1999: Mark L Greenlee; JB Laub; Gregory P Rouen; Frank DiNinno; Milton L Hammond; JL Huber; Jon Sundelof; GG Hammond
Dicationic 2-fluorenonylcarbapenems: potent anti-MRS agents with improved solubility and pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 1999;9(22):3225-30.
1999: Mark L Greenlee; JB Laub; James M Balkovec; Milton L Hammond; GG Hammond; DL Pompliano; J H Epstein-Toney
Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase.
Bioorganic & medicinal chemistry letters 1999;9(17):2549-54.
1999: Ronald W Ratcliffe; Robert R Wilkening; Kenneth J Wildonger; Sherman Waddell; Gina Santorelli; D L Parker; Jerry D Morgan; Timothy A Blizzard; Milton L Hammond; James V Heck; J Huber; Joyce Kohler; Karen Dorso; E St Rose; Jon Sundelof; WJ May; GG Hammond
Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: discovery of L-786,392.
Bioorganic & medicinal chemistry letters 1999;9(5):679-84.
1999: Robert R Wilkening; Ronald W Ratcliffe; Kenneth J Wildonger; L D Cama; Kevin D Dykstra; Frank DiNinno; Timothy A Blizzard; Milton L Hammond; James V Heck; Karen Dorso; E St Rose; Joyce Kohler; GG Hammond
Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore.
Bioorganic & medicinal chemistry letters 1999;9(5):673-8.
1999: Hugh Rosen; Richard Hajdu; Lynn Silver; H Kropp; Karen Dorso; Joyce Kohler; Jon Sundelof; J Huber; GG Hammond; Jesse J Jackson; Charles J Gill; R Thompson; BA Pelak; J H Epstein-Toney; G Lankas; Robert R Wilkening; Kenneth J Wildonger; Timothy A Blizzard; Frank DiNinno; Ronald W Ratcliffe; James V Heck; John W Kozarich; Milton L Hammond
Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.
Science (New York, N.Y.) 1999;283(5402):703-6.
1994: F A Bouffard; R A Zambias; James F Dropinski; J M Balkovec; Milton L Hammond; George K Abruzzo; Ken Bartizal; J A Marrinan; Myra B Kurtz; D C McFadden
Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives.
Journal of medicinal chemistry 1994;37(2):222-5.
1992: R A Zambias; Milton L Hammond; James V Heck; Ken Bartizal; C Trainor; George K Abruzzo; Dennis M Schmatz; K M Nollstadt
Preparation and structure-activity relationships of simplified analogues of the antifungal agent cilofungin: a total synthesis approach.
Journal of medicinal chemistry 1992;35(15):2843-55.
1992: J M Balkovec; R M Black; Milton L Hammond; James V Heck; R A Zambias; George K Abruzzo; Ken Bartizal; H Kropp; C Trainor; R E Schwartz
Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP).
Journal of medicinal chemistry 1992;35(1):194-8.
1990: Milton L Hammond; R A Zambias; M N Chang; N P Jensen; J McDonald; K Thompson; D A Boulton; Ihor Kopka; K M Hand; E E Opas
Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent.
Journal of medicinal chemistry 1990;33(3):908-18.
1989: Milton L Hammond; Ihor Kopka; R A Zambias; C G Caldwell; J Boger; F Baker; T Bach; Silvi Luell; D E MacIntyre
2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.
Journal of medicinal chemistry 1989;32(5):1006-20.