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Jiahuai Han

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
19
Ulevitch, Richard
14
New, Liguo
11
Kim, Sung
10
Gram, Hermann
8
Jiang, Yong
8
Li, Qinxi
8
Di Padova, Franco
7
Lin, Sheng-Cai
7
Huang, Shuang
7
Kähäri, Veli-Matti
6
Ye, Zhiyun
6
Li, Jian-Dong
6
Broek, Daniel
5
Chen, Guan
5
Chen, Jianming

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Publications

TOP 3
Li Qinxi; Lin Shuyong; Wang Xuan; Lian Guili; Lu Zailian; Guo Huiling; Ruan Ka; Wang Yanhai; Ye Zhiyun; Han Jiahuai; Lin Sheng-Cai
Axin determines cell fate by controlling the p53 activation threshold after DNA damage.
Zhang Duan-Wu; Shao Jing; Lin Juan; Zhang Na; Lu Bao-Ju; Lin Sheng-Cai; Dong Meng-Qiu; Han Jiahuai
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
Su Rongmin; Li Lei; Chen Xiaoping; Han Jiahuai; Han Shoufa
Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}.

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All Publications

2009: Li Qinxi; Lin Shuyong; Wang Xuan; Lian Guili; Lu Zailian; Guo Huiling; Ruan Ka; Wang Yanhai; Ye Zhiyun; Han Jiahuai; Lin Sheng-Cai
Axin determines cell fate by controlling the p53 activation threshold after DNA damage.
Nature cell biology 2009;11(9):1128-34.
2009: Zhang Duan-Wu; Shao Jing; Lin Juan; Zhang Na; Lu Bao-Ju; Lin Sheng-Cai; Dong Meng-Qiu; Han Jiahuai
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
Science (New York, N.Y.) 2009;325(5938):332-6.
2009: Su Rongmin; Li Lei; Chen Xiaoping; Han Jiahuai; Han Shoufa
Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}.
Organic & biomolecular chemistry 2009;7(10):2040-5.
2009: Fang Weijun; Cai Yijun; Chen Xiaoping; Su Rongmin; Chen Tong; Xia Ningshao; Li Lei; Yang Quanli; Han Jiahuai; Han Shoufa
Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates.
Bioorganic & medicinal chemistry letters 2009;19(7):1903-7.
2009: Kwong Jinny; Hong Lixin; Liao Rong; Deng Qingdong; Han Jiahuai; Sun Peiqing
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.
The Journal of biological chemistry 2009;284(17):11237-46.
2009: Nagy Zita; Riss Anne; Romier Christophe; le Guezennec Xavier; Dongre Ashok R; Orpinell Meritxell; Han Jiahuai; Stunnenberg Henk; Tora Làszlò
The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.
Molecular and cellular biology 2009;29(6):1649-60.
2009: Ren Jian-Lin; Pan Jin-Shui; Lu Ya-Pi; Sun Peiqing; Han Jiahuai
Inflammatory signaling and cellular senescence.
Cellular signalling 2009;21(3):378-83.
2008: Hu Xiaoyu; Chung Allen Y; Wu Indira; Foldi Julia; Chen Janice; Ji Jong Dae; Tateya Tomoko; Kang Young Jun; Han Jiahuai; Gessler Manfred; Kageyama Ryoichiro; Ivashkiv Lionel B
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Immunity 2008;29(5):691-703.
2008: van den Berg Arjen; Mols Johann; Han Jiahuai
RISC-target interaction: cleavage and translational suppression.
Biochimica et biophysica acta 2008;1779(11):668-77.
2008: Mols Johann; van den Berg Arjen; Otsuka Motoyuki; Zheng Min; Chen Jianming; Han Jiahuai
TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization.
Biochimica et biophysica acta 2008;1779(11):712-9.
2008: Ha Soon-Duck; Martins Andrew; Khazaie Khashayarsha; Han Jiahuai; Chan Bosco M C; Kim Sung Ouk
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):690-7.
2008: Abidi Parveen; Zhang Haiyan; Zaidi Syed M; Shen Wen-Jun; Leers-Sucheta Susan; Cortez Yuan; Han Jiahuai; Azhar Salman
Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway.
The Journal of endocrinology 2008;198(1):193-207.
2008: Zhuang Shougang; Kinsey Gilbert R; Yan Yan; Han Jiahuai; Schnellmann Rick G
Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells.
The Journal of pharmacology and experimental therapeutics 2008;325(3):732-40.
2008: Otsuka Motoyuki; Zheng Min; Hayashi Masaaki; Lee Jing-Dwan; Yoshino Osamu; Lin Shengcai; Han Jiahuai
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice.
The Journal of clinical investigation 2008;118(5):1944-54.
2008: Kang Young Jun; Chen Jianming; Otsuka Motoyuki; Mols Johann; Ren Shuxun; Wang Yinbin; Han Jiahuai
Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5075-82.
2008: Li Qinxi; Zhang Na; Zhang Duanwu; Wang Yuqian; Lin Tianwei; Wang Yanhai; Zhou Huamin; Ye Zhiyun; Zhang Faming; Lin Sheng-Cai; Han Jiahuai
Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes.
The Journal of biological chemistry 2008;283(16):11014-23.
2008: Abidi Parveen; Leers-Sucheta Susan; Cortez Yuan; Han Jiahuai; Azhar Salman
Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats.
Aging cell 2008;7(2):168-78.
2008: Xu Chenyu; Gu Ying; Hou Wangheng; Cheng Tong; Zhang Tao; Que Yuqiong; Gao Shuangquan; Zhang Jun; Han Jiahuai; Xia Ningshao
[Construction of a novel gene therapy lentiviral vector for drug resistant selection and detection in vivo]
Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2008;24(2):256-61.
2007: Yang Ziqiang; Cheng Wei; Hong Lixin; Chen Wanze; Wang Yanhai; Lin Shengcai; Han Jiahuai; Zhou Huamin; Gu Jun
Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells.
Molecular biology of the cell 2007;18(11):4681-9.
2007: Kang Young Jun; Kusler Brenda; Otsuka Motoyuki; Hughes Michael; Suzuki Nobutaka; Suzuki Shinobu; Yeh Wen-Chen; Akira Shizuo; Han Jiahuai; Jones Patricia P
Calcineurin negatively regulates TLR-mediated activation pathways.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4598-607.
2007: Gills Joell J; Castillo S Sianna; Zhang Chunyu; Petukhov Pavel A; Memmott Regan M; Hollingshead Melinda; Warfel Noel; Han Jiahuai; Kozikowski Alan P; Dennis Phillip A
Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.
The Journal of biological chemistry 2007;282(37):27020-9.
2007: Ha Soon-Duck; Ng Dennis; Lamothe Julie; Valvano Miguel A; Han Jiahuai; Kim Sung Ouk
Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death.
The Journal of biological chemistry 2007;282(36):26275-83.
2007: Hisatsune Junzo; Yamasaki Eiki; Nakayama Masaaki; Shirasaka Daisuke; Kurazono Hisao; Katagata Yohtaro; Inoue Hiroyasu; Han Jiahuai; Sap Jan; Yahiro Kinnosuke; Moss Joel; Hirayama Toshiya
Helicobacter pylori VacA enhances prostaglandin E2 production through induction of cyclooxygenase 2 expression via a p38 mitogen-activated protein kinase/activating transcription factor 2 cascade in AZ-521 cells.
Infection and immunity 2007;75(9):4472-81.
2007: Cook Ryan; Wu Chia-Cheng; Kang Young Jun; Han Jiahuai
The role of the p38 pathway in adaptive immunity.
Cellular & molecular immunology 2007;4(4):253-9.
2007: Rui Yanning; Xu Zhen; Xiong Bo; Cao Ying; Lin Shuyong; Zhang Min; Chan Siu-Chiu; Luo Wen; Han Ying; Lu Zailian; Ye Zhiyun; Zhou Hai-Meng; Han Jiahuai; Meng Anming; Lin Sheng-Cai
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.
Developmental cell 2007;13(2):268-82.
2007: Han Jiahuai; Sun Peiqing
The pathways to tumor suppression via route p38.
Trends in biochemical sciences 2007;32(8):364-71.
2007: Otsuka Motoyuki; Jing Qing; Georgel Philippe; New Liguo; Chen Jianming; Mols Johann; Kang Young Jun; Jiang Zhengfan; Du Xin; Cook Ryan; Das Subash C; Pattnaik Asit K; Beutler Bruce; Han Jiahuai
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Immunity 2007;27(1):123-34.
2007: Hao Feng; Tan Mingqi; Xu Xuemin; Han Jiahuai; Miller Duane D; Tigyi Gabor; Cui Mei-Zhen
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha.
Biochimica et biophysica acta 2007;1771(7):883-92.
2007: Lu Miao; Lin Su-Chang; Huang Yihua; Kang Young Jun; Rich Rebecca; Lo Yu-Chih; Myszka David; Han Jiahuai; Wu Hao
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
Molecular cell 2007;26(5):689-702.
2007: Kang Young Jun; Kim Sung Ouk; Shimada Shigeki; Otsuka Motoyuki; Seit-Nebi Alim; Kwon Byoung S; Watts Tania H; Han Jiahuai
Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.
Nature immunology 2007;8(6):601-9.
2007: Kim Sung O; Ha Soon-Duck; Lee Sangun; Stanton Sarah; Beutler Bruce; Han Jiahuai
Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells.
BioTechniques 2007;42(4):493-501.
2007: Sun Peiqing; Yoshizuka Naoto; New Liguo; Moser Bettina A; Li Yilei; Liao Rong; Xie Changchuan; Chen Jianming; Deng Qingdong; Yamout Maria; Dong Meng-Qiu; Frangou Costas G; Yates John R; Wright Peter E; Han Jiahuai
PRAK is essential for ras-induced senescence and tumor suppression.
Cell 2007;128(2):295-308.
2007: Zou Haiying; Li Qinxi; Lin Sheng-Cai; Wu Zhenguo; Han Jiahuai; Ye Zhiyun
Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins.
FEBS letters 2007;581(2):196-202.
2007: Zhuang Shougang; Yan Yan; Daubert Rebecca A; Han Jiahuai; Schnellmann Rick G
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells.
American journal of physiology. Renal physiology 2007;292(1):F440-7.
2006: Keum Young-Sam; Yu Siwang; Chang Peter Pil-Jae; Yuan Xiaoling; Kim Jung-Hwan; Xu Changjiang; Han Jiahuai; Agarwal Anupam; Kong Ah-Ng Tony
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
Cancer research 2006;66(17):8804-13.
2006: Kang Young Jun; Seit-Nebi Alim; Davis Roger J; Han Jiahuai
Multiple activation mechanisms of p38alpha mitogen-activated protein kinase.
The Journal of biological chemistry 2006;281(36):26225-34.
2006: Xu Yue; Kim Sung Ouk; Li Yilei; Han Jiahuai
Autophagy contributes to caspase-independent macrophage cell death.
The Journal of biological chemistry 2006;281(28):19179-87.
2006: Zohn Irene E; Li Yingqiu; Skolnik Edward Y; Anderson Kathryn V; Han Jiahuai; Niswander Lee
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.
Cell 2006;125(5):957-69.
2006: Zhou Huamin; Zheng Min; Chen Jianming; Xie Changchuan; Kolatkar Anand R; Zarubin Tyler; Ye Zhiyun; Akella Radha; Lin Shengcai; Goldsmith Elizabeth J; Han Jiahuai
Determinants that control the specific interactions between TAB1 and p38alpha.
Molecular and cellular biology 2006;26(10):3824-34.
2006: Liu Wei; Rui Hongliang; Wang Jifeng; Lin Shuyong; He Ying; Chen Mingliang; Li Qinxi; Ye Zhiyun; Zhang Suping; Chan Siu Chiu; Chen Ye-Guang; Han Jiahuai; Lin Sheng-Cai
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
The EMBO journal 2006;25(8):1646-58.
2006: Han Jiahuai
MyD88 beyond Toll.
Nature immunology 2006;7(4):370-1.
2006: Xu Yue; Huang Shuang; Liu Zheng-Gang; Han Jiahuai
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation.
The Journal of biological chemistry 2006;281(13):8788-95.
2006: Lu Gang; Kang Young Jun; Han Jiahuai; Herschman Harvey R; Stefani Enrico; Wang Yibin
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
The Journal of biological chemistry 2006;281(9):6087-95.
2006: da Silva Correia Jean; Miranda Yvonne; Austin-Brown Nikki; Hsu Jenny; Mathison John; Xiang Rong; Zhou Huamin; Li Qinxi; Han Jiahuai; Ulevitch Richard J
Nod1-dependent control of tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1840-5.
2006: Li Zhenyu; Zhang Guoying; Feil Robert; Han Jiahuai; Du Xiaoping
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3.
Blood 2006;107(3):965-72.
2006: Fu Jing; Yang Ziqiang; Wei Jinxue; Han Jiahuai; Gu Jun
Nuclear protein NP60 regulates p38 MAPK activity.
Journal of cell science 2006;119(Pt 1):115-23.
2005: Han Jiahuai; Ulevitch Richard J
Limiting inflammatory responses during activation of innate immunity.
Nature immunology 2005;6(12):1198-205.
2005: Al Sarraj Jude; Vinson Charles; Han Jiahuai; Thiel Gerald
Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors.
Journal of cellular biochemistry 2005;96(5):1003-20.
2005: Shi Geng-Xian; Han Jiahuai; Andres Douglas A
Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.
The Journal of biological chemistry 2005;280(45):37599-609.
2005: Meng Fanyin; Yamagiwa Yoko; Taffetani Silvia; Han Jiahuai; Patel Tushar
IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway.
American journal of physiology. Cell physiology 2005;289(4):C971-81.
2005: Xie Changchuan; Zhang Na; Zhou Huamin; Li Jinquan; Li Qinxi; Zarubin Tyler; Lin Sheng-Cai; Han Jiahuai
Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells.
Molecular and cellular biology 2005;25(15):6673-81.
2005: Zhu Xiongwei; Mei Matthew; Lee Hyoung-Gon; Wang Yang; Han Jiahuai; Perry George; Smith Mark A
P38 activation mediates amyloid-beta cytotoxicity.
Neurochemical research 2005;30(6-7):791-6.
2005: Zarubin Tyler; Jing Qing; New Liguo; Han Jiahuai
Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells.
Cell research 2005;15(6):439-46.
2005: Tang Jun; Qi Xiaomei; Mercola Dan; Han Jiahuai; Chen Guan
Essential role of p38gamma in K-Ras transformation independent of phosphorylation.
The Journal of biological chemistry 2005;280(25):23910-7.
2005: Zhuang Shougang; Yan Yan; Han Jiahuai; Schnellmann Rick G
p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury.
The Journal of biological chemistry 2005;280(22):21036-42.
2005: Jing Qing; Huang Shuang; Guth Sabine; Zarubin Tyler; Motoyama Andrea; Chen Jianming; Di Padova Franco; Lin Sheng-Cai; Gram Hermann; Han Jiahuai
Involvement of microRNA in AU-rich element-mediated mRNA instability.
Cell 2005;120(5):623-34.
2005: Zarubin Tyler; Han Jiahuai
Activation and signaling of the p38 MAP kinase pathway.
Cell research 2005;15(1):11-8.
2005: Zhou Huamin; Zarubin Tyler; Ji Zhiliang; Min Zheng; Zhu Wei; Downey Jocelyn S; Lin Shengcai; Han Jiahuai
Frequency and distribution of AP-1 sites in the human genome.
DNA research : an international journal for rapid publication of reports on genes and genomes 2005;12(2):139-50.
2004: Rui Yanning; Xu Zhen; Lin Shuyong; Li Qinxi; Rui Hongliang; Luo Wen; Zhou Hai-Meng; Cheung Po-Yan; Wu Zhenguo; Ye Zhiyun; Li Peng; Han Jiahuai; Lin Sheng-Cai
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.
The EMBO journal 2004;23(23):4583-94.
2004: Li Jinquan; Li Qinxi; Xie Changchuan; Zhou Huamin; Wang Yuqian; Zhang Na; Shao Hanjuan; Chan Siu Chiu; Peng Xuanxian; Lin Sheng-Cai; Han Jiahuai
Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death.
Journal of cell science 2004;117(Pt 20):4673-80.
2004: Cao Jiong; Semenova Maria M; Solovyan Victor T; Han Jiahuai; Coffey Eleanor T; Courtney Michael J
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death.
The Journal of biological chemistry 2004;279(34):35903-13.
2004: Sakai Akihiro; Han Jiahuai; Cato Andrew C B; Akira Shizuo; Li Jian-Dong
Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells.
BMC molecular biology 2004;5():2.
2004: Qi Xiaomei; Tang Jun; Pramanik Rocky; Schultz Richard M; Shirasawa Senji; Sasazuki Takehiko; Han Jiahuai; Chen Guan
p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor.
The Journal of biological chemistry 2004;279(21):22138-44.
2004: Shen Guoxiang; Hebbar Vidya; Nair Sujit; Xu Changjiang; Li Wenge; Lin Wen; Keum Young-Sam; Han Jiahuai; Gallo Michael A; Kong A-N Tony
Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein.
The Journal of biological chemistry 2004;279(22):23052-60.
2004: Watanabe Takahiro; Jono Hirofumi; Han Jiahuai; Lim David J; Li Jian-Dong
Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3563-8.
2004: Bossy-Wetzel Ella; Talantova Maria V; Lee Wilson D; Schölzke Marion N; Harrop Anne; Mathews Emily; Götz Thomas; Han Jiahuai; Ellisman Mark H; Perkins Guy A; Lipton Stuart A
Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels.
Neuron 2004;41(3):351-65.
2004: Qi Xiaomei; Borowicz Stanley; Pramanik Rocky; Schultz Richard M; Han Jiahuai; Chen Guan
Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells.
The Journal of biological chemistry 2004;279(8):6769-77.
2004: Bradley Kathleen; Scatizzi John C; Fiore Stefano; Shamiyeh Eli; Koch Alisa E; Firestein Gary S; Gorges Laura L; Kuntsman Kevin; Pope Richard M; Moore Terry L; Han Jiahuai; Perlman Harris
Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2004;50(1):78-87.
2003: Hoebe Kasper; Janssen Edith M; Kim Sung O; Alexopoulou Lena; Flavell Richard A; Han Jiahuai; Beutler Bruce
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.
Nature immunology 2003;4(12):1223-9.
2003: Pace Betty S; Qian Xin-hua; Sangerman Jose; Ofori-Acquah Solomon F; Baliga B Surendra; Han Jiahuai; Critz Stuart D
p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors.
Experimental hematology 2003;31(11):1089-96.
2003: Luo Wen; Ng Wilson W; Jin Li-Hua; Ye Zhiyun; Han Jiahuai; Lin Sheng-Cai
Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.
The Journal of biological chemistry 2003;278(39):37451-8.
2003: Shalizi Aryaman; Lehtinen Maria; Gaudilliere Brice; Donovan Nicole; Han Jiahuai; Konishi Yoshiyuki; Bonni Azad
Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(19):7326-36.
2003: Hoebe K; Du X; Georgel P; Janssen E; Tabeta K; Kim S O; Goode J; Lin P; Mann N; Mudd S; Crozat K; Sovath S; Han J; Beutler B
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
Nature 2003;424(6950):743-8.
2003: Li Song-Ping; Junttila Melissa R; Han Jiahuai; Kähäri Veli-Matti; Westermarck Jukka
p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.
Cancer research 2003;63(13):3473-7.
2003: New Liguo; Jiang Yong; Han Jiahuai
Regulation of PRAK subcellular location by p38 MAP kinases.
Molecular biology of the cell 2003;14(6):2603-16.
2003: Kim Sung Ouk; Ono Koh; Tobias Peter S; Han Jiahuai
Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death.
The Journal of experimental medicine 2003;197(11):1441-52.
2003: Zhu Wen-Hui; Han Jiahuai; Nicosia Roberto Francesco
Requisite role of p38 MAPK in mural cell recruitment during angiogenesis in the rat aorta model.
Journal of vascular research 2003;40(2):140-8.
2003: Iwasa Hiroaki; Han Jiahuai; Ishikawa Fuyuki
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(2):131-44.
2003: Kim Sung O; Jing Qing; Hoebe Kasper; Beutler Bruce; Duesbery Nicholas S; Han Jiahuai
Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha.
The Journal of biological chemistry 2003;278(9):7413-21.
2003: Pramanik Rocky; Qi Xiaomei; Borowicz Stanley; Choubey Divaker; Schultz Richard M; Han Jiahuai; Chen Guan
p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity.
The Journal of biological chemistry 2003;278(7):4831-9.
2003: Hsu Shu-Ching; Wu Chia-Cheng; Han Jiahuai; Lai Ming-Zong
Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development.
Blood 2003;101(3):970-6.
2003: Ono Koh; Kim Sung O; Han Jiahuai
Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death.
Molecular and cellular biology 2003;23(2):665-76.
2003: Ge Baoxue; Xiong Xinsheng; Jing Qing; Mosley Jennifer L; Filose Angela; Bian Dafang; Huang Shuang; Han Jiahuai
TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1.
The Journal of biological chemistry 2003;278(4):2286-93.
2002: Vachon Pierre H; Harnois Charlène; Grenier Amélie; Dufour Geneviève; Bouchard Véronique; Han Jiahuai; Landry Jacques; Beaulieu Jean-Fraçois; Vézina Anne; Dydensborg Anders Bondo; Gauthier Rémy; Côté André; Drolet Jean-Fraçois; Lareau Fraçois
Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis.
Gastroenterology 2002;123(6):1980-91.
2002: Han Qiwei; Leng Jay; Bian Dafang; Mahanivong Chitladda; Carpenter Kevin A; Pan Zhixing K; Han Jiahuai; Huang Shuang
Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells.
The Journal of biological chemistry 2002;277(50):48379-85.
2002: Imasato Akira; Desbois-Mouthon Christéle; Han Jiahuai; Kai Hirofumi; Cato Andrew C B; Akira Shizuo; Li Jian-Dong
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2.
The Journal of biological chemistry 2002;277(49):47444-50.
2002: Leivonen Suvi-Katri; Chantry Andrew; Hakkinen Lari; Han Jiahuai; Kahari Veli-Matti
Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways.
The Journal of biological chemistry 2002;277(48):46338-46.
2002: Reunanen Niina; Li Song-Ping; Ahonen Matti; Foschi Marco; Han Jiahuai; Kähäri Veli-Matti
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization.
The Journal of biological chemistry 2002;277(35):32360-8.
2002: Qi Xiaomei; Pramanik Rocky; Wang Jintang; Schultz Richard M; Maitra Ratan K; Han Jiahuai; DeLuca Hector F; Chen Guan
The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition.
The Journal of biological chemistry 2002;277(29):25884-92.
2002: Zhao Ming; Liu Yawei; Wang Xiaofei; New Liguo; Han Jiahuai; Brunk Ulf T
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002;110(6):458-68.
2002: Zhang Yi; Qiu Wen-Jie; Chan Siu Chiu; Han Jiahuai; He Xi; Lin Sheng-Cai
Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways.
The Journal of biological chemistry 2002;277(20):17706-12.
2002: Shuto Tsuyoshi; Imasato Akira; Jono Hirofumi; Sakai Akihiro; Xu Haidong; Watanabe Takahiro; Rixter Davida D; Kai Hirofumi; Andalibi Ali; Linthicum Fred; Guan Yue-Ling; Han Jiahuai; Cato Andrew C B; Lim David J; Akira Shizuo; Li Jian-Dong
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase.
The Journal of biological chemistry 2002;277(19):17263-70.
2002: Zhao Ming; Liu Yawei; Bao Mingmin; Kato Yutaka; Han Jiahuai; Eaton John W
Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases.
Archives of biochemistry and biophysics 2002;400(2):199-207.
2002: Mansky Kim C; Sankar Uma; Han Jiahuai; Ostrowski Michael C
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling.
The Journal of biological chemistry 2002;277(13):11077-83.
2002: Ge Baoxue; Gram Hermann; Di Padova Franco; Huang Betty; New Liguo; Ulevitch Richard J; Luo Ying; Han Jiahuai
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.
Science (New York, N.Y.) 2002;295(5558):1291-4.
2002: Wang Beinan; Lim David J; Han Jiahuai; Kim Young S; Basbaum Carol B; Li Jian-Dong
Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway.
The Journal of biological chemistry 2002;277(2):949-57.
2001: Li W; Nadelman C; Henry G; Fan J; Muellenhoff M; Medina E; Gratch N S; Chen M; Han J; Woodley D
The p38-MAPK/SAPK pathway is required for human keratinocyte migration on dermal collagen.
The Journal of investigative dermatology 2001;117(6):1601-11.
2001: Ono K; Wang X; Han J
Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency.
Molecular and cellular biology 2001;21(24):8276-88.
2001: Kim S O; Ono K; Han J
Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages.
American journal of physiology. Lung cellular and molecular physiology 2001;281(5):L1095-105.
2001: Xi X; Han J; Zhang J Z
Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase.
The Journal of biological chemistry 2001;276(44):41029-34.
2001: Han J; Liu S; Rose D M; Schlaepfer D D; McDonald H; Ginsberg M H
Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding.
The Journal of biological chemistry 2001;276(44):40903-9.
2001: Zhu W; Brauchle M A; Di Padova F; Gram H; New L; Ono K; Downey J S; Han J
Gene suppression by tristetraprolin and release by the p38 pathway.
American journal of physiology. Lung cellular and molecular physiology 2001;281(2):L499-508.
2001: Shuto T; Xu H; Wang B; Han J; Kai H; Gu X X; Murphy T F; Lim D J; Li J D
Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8774-9.
2001: Ravanti L; Toriseva M; Penttinen R; Crombleholme T; Foschi M; Han J; Kähäri V M
Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1098-100.
2001: Westermarck J; Li S P; Kallunki T; Han J; Kähäri V M
p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
Molecular and cellular biology 2001;21(7):2373-83.
2001: Gong X; Wang X; Han J; Niesman I; Huang Q; Horwitz J
Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens.
Investigative ophthalmology & visual science 2001;42(3):539-48.
2001: New L; Li Y; Ge B; Zhong H; Mansbridge J; Liu K; Han J
SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway.
Journal of cellular biochemistry 2001;83(4):585-96.
2001: Kim S O; Han J
Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages.
Journal of endotoxin research 2001;7(4):292-6.
2001: Hughes P E; Oertli B; Han J; Ginsberg M H
R-Ras regulation of integrin function.
Methods in enzymology 2001;333():163-71.
2000: Li Y; Jiang B; Ensign W Y; Vogt P K; Han J
Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase.
Cellular signalling 2000;12(11-12):751-7.
2000: Reunanen N; Foschi M; Han J; Kahari V M
Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts.
The Journal of biological chemistry 2000;275(44):34634-9.
2000: Oertli B; Han J; Marte B M; Sethi T; Downward J; Ginsberg M; Hughes P E
The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
Oncogene 2000;19(43):4961-9.
2000: Liu S; Rose D M; Han J; Ginsberg M H
Alpha4 integrins in cardiovascular development and diseases.
Trends in cardiovascular medicine 2000;10(6):253-7.
2000: Brauchle M; Glück D; Di Padova F; Han J; Gram H
Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1.
Experimental cell research 2000;258(1):135-44.
2000: Wang X; McGowan C H; Zhao M; He L; Downey J S; Fearns C; Wang Y; Huang S; Han J
Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.
Molecular and cellular biology 2000;20(13):4543-52.
2000: Zhu W; Downey J S; Gu J; Di Padova F; Gram H; Han J
Regulation of TNF expression by multiple mitogen-activated protein kinase pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6349-58.
2000: Fearns C; Kline L; Gram H; Di Padova F; Zurini M; Han J; Ulevitch R J
Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli.
Journal of leukocyte biology 2000;67(5):705-11.
2000: Das B; Shu X; Day G J; Han J; Krishna U M; Falck J R; Broek D
Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.
The Journal of biological chemistry 2000;275(20):15074-81.
2000: Tschopp C; Knauf U; Brauchle M; Zurini M; Ramage P; Glueck D; New L; Han J; Gram H
Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies.
Molecular cell biology research communications : MCBRC 2000;3(4):205-211.
2000: Huang S; New L; Pan Z; Han J; Nemerow G R
Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity.
The Journal of biological chemistry 2000;275(16):12266-72.
2000: Han J; Molkentin J D
Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology.
Trends in cardiovascular medicine 2000;10(1):19-22.
2000: Ono K; Han J
The p38 signal transduction pathway: activation and function.
Cellular signalling 2000;12(1):1-13.
2000: Mosteller R; Han J; Das B; Broek D
Biochemical analysis of regulation of Vav, a guanine-nucleotide exchange factor for Rho family of GTPases.
Methods in enzymology 2000;325():38-51.
1999: Ravanti L; Häkkinen L; Larjava H; Saarialho-Kere U; Foschi M; Han J; Kähäri V M
Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase.
The Journal of biological chemistry 1999;274(52):37292-300.
1999: New L; Zhao M; Li Y; Bassett W W; Feng Y; Ludwig S; Padova F D; Gram H; Han J
Cloning and characterization of RLPK, a novel RSK-related protein kinase.
The Journal of biological chemistry 1999;274(2):1026-32.
1999: Zhao M; New L; Kravchenko V V; Kato Y; Gram H; di Padova F; Olson E N; Ulevitch R J; Han J
Regulation of the MEF2 family of transcription factors by p38.
Molecular and cellular biology 1999;19(1):21-30.
1998: Kusuhara M; Takahashi E; Peterson T E; Abe J; Ishida M; Han J; Ulevitch R; Berk B C
p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2.
Circulation research 1998;83(8):824-31.
1998: New L; Han J
The p38 MAP kinase pathway and its biological function.
Trends in cardiovascular medicine 1998;8(5):220-8.
1998: New L; Jiang Y; Zhao M; Liu K; Zhu W; Flood L J; Kato Y; Parry G C; Han J
PRAK, a novel protein kinase regulated by the p38 MAP kinase.
The EMBO journal 1998;17(12):3372-84.
1998: Downey J S; Han J
Cellular activation mechanisms in septic shock.
Frontiers in bioscience : a journal and virtual library 1998;3():d468-76.
1998: Han J; Luby-Phelps K; Das B; Shu X; Xia Y; Mosteller R D; Krishna U M; Falck J R; White M A; Broek D
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav.
Science (New York, N.Y.) 1998;279(5350):558-60.
1997: Kato Y; Kravchenko V V; Tapping R I; Han J; Ulevitch R J; Lee J D
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.
The EMBO journal 1997;16(23):7054-66.
1997: Jiang Y; Gram H; Zhao M; New L; Gu J; Feng L; Di Padova F; Ulevitch R J; Han J
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.
The Journal of biological chemistry 1997;272(48):30122-8.
1997: Huang S; Jiang Y; Li Z; Nishida E; Mathias P; Lin S; Ulevitch R J; Nemerow G R; Han J
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b.
Immunity 1997;6(6):739-49.
1997: Jiang Y; Li Z; Schwarz E M; Lin A; Guan K; Ulevitch R J; Han J
Structure-function studies of p38 mitogen-activated protein kinase. Loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection.
The Journal of biological chemistry 1997;272(17):11096-102.
1997: Han J; Jiang Y; Li Z; Kravchenko V V; Ulevitch R J
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
Nature 1997;386(6622):296-9.
1997: Han J; Das B; Wei W; Van Aelst L; Mosteller R D; Khosravi-Far R; Westwick J K; Der C J; Broek D
Lck regulates Vav activation of members of the Rho family of GTPases.
Molecular and cellular biology 1997;17(3):1346-53.
1997: Han J; Wang X; Jiang Y; Ulevitch R J; Lin S
Identification and characterization of a predominant isoform of human MKK3.
FEBS letters 1997;403(1):19-22.
1996: Li Z; Jiang Y; Ulevitch R J; Han J
The primary structure of p38 gamma: a new member of p38 group of MAP kinases.
Biochemical and biophysical research communications 1996;228(2):334-40.
1996: Jiang Y; Chen C; Li Z; Guo W; Gegner J A; Lin S; Han J
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).
The Journal of biological chemistry 1996;271(30):17920-6.
1996: Quilliam L A; Hisaka M M; Zhong S; Lowry A; Mosteller R D; Han J; Drugan J K; Broek D; Campbell S L; Der C J
Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.
The Journal of biological chemistry 1996;271(19):11076-82.
1996: Han J; Lee J D; Jiang Y; Li Z; Feng L; Ulevitch R J
Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
The Journal of biological chemistry 1996;271(6):2886-91.
1995: Zhang S; Han J; Sells M A; Chernoff J; Knaus U G; Ulevitch R J; Bokoch G M
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.
The Journal of biological chemistry 1995;270(41):23934-6.
1995: Lee J D; Ulevitch R J; Han J
Primary structure of BMK1: a new mammalian map kinase.
Biochemical and biophysical research communications 1995;213(2):715-24.
1995: Kravchenko V V; Pan Z; Han J; Herbert J M; Ulevitch R J; Ye R D
Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway.
The Journal of biological chemistry 1995;270(25):14928-34.
1995: Raingeaud J; Gupta S; Rogers J S; Dickens M; Han J; Ulevitch R J; Davis R J
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
The Journal of biological chemistry 1995;270(13):7420-6.
1995: Dérijard B; Raingeaud J; Barrett T; Wu I H; Han J; Ulevitch R J; Davis R J
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.
Science (New York, N.Y.) 1995;267(5198):682-5.
1994: Han J; Mathison J C; Ulevitch R J; Tobias P S
Lipopolysaccharide (LPS) binding protein, truncated at Ile-197, binds LPS but does not transfer LPS to CD14.
The Journal of biological chemistry 1994;269(11):8172-5.
1994: Mosteller R D; Han J; Broek D
Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors.
Molecular and cellular biology 1994;14(2):1104-12.
1994: Tobias P S; Gegner J; Han J; Kirkland T; Kravchenko V; Leturcq D; Lee J D; Moriarty A; Mathison J C; Pugin J
LPS binding protein and CD14 in the LPS dependent activation of cells.
Progress in clinical and biological research 1994;388():31-9.
1993: Lee J D; Kravchenko V; Kirkland T N; Han J; Mackman N; Moriarty A; Leturcq D; Tobias P S; Ulevitch R J
Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9930-4.
1993: Han J; Lee J D; Tobias P S; Ulevitch R J
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.
The Journal of biological chemistry 1993;268(33):25009-14.

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