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Marcello Arsura

Research Profile

Chemicals & Drugs

Living Beings

Mouse

Physiology

Anatomy

Disorders

Carcinoma, Hepatocellular

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Publications

TOP 3
Fang Wang; Swayamjot Kaur; Lakita G Cavin; Marcello Arsura
Nuclear-factor-kappaB (NF-kappaB) and radical oxygen species play contrary roles in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in hepatocellular carcinoma (HCC) cells.
Wenlin Deng; E Shuyu; Ryoko Tsukahara; William J Valentine; Gangadhar G Durgam; Veeresa Gududuru; Louisa Balazs; Venkatraman Manickam; Marcello Arsura; Lester VanMiddlesworth; Leonard R Johnson; Abby L Parrill; Duane D Miller; Gabor Tigyi
The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.
Swayamjot Kaur; Fang Wang; Manickam Venkatraman; Marcello Arsura
X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1).

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All Publications

2008: Fang Wang; Swayamjot Kaur; Lakita G Cavin; Marcello Arsura
Nuclear-factor-kappaB (NF-kappaB) and radical oxygen species play contrary roles in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in hepatocellular carcinoma (HCC) cells.
Biochemical and biophysical research communications 2008;377(4):1107-12.
2007: Wenlin Deng; E Shuyu; Ryoko Tsukahara; William J Valentine; Gangadhar G Durgam; Veeresa Gududuru; Louisa Balazs; Venkatraman Manickam; Marcello Arsura; Lester VanMiddlesworth; Leonard R Johnson; Abby L Parrill; Duane D Miller; Gabor Tigyi
The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.
Gastroenterology 2007;132(5):1834-51.
2005: Swayamjot Kaur; Fang Wang; Manickam Venkatraman; Marcello Arsura
X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1).
The Journal of biological chemistry 2005;280(46):38599-608.
2005: Marcello Arsura; Lakita G Cavin
Nuclear factor-kappaB and liver carcinogenesis.
Cancer letters 2005;229(2):157-69.
2005: Lakita G Cavin; Fang Wang; Valentina M Factor; Swayamjot Kaur; Manickam Venkatraman; Snorri S Thorgeirsson; Marcello Arsura
Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomas.
Molecular cancer research : MCR 2005;3(7):403-12.
2004: Lakita G Cavin; Manickam Venkatraman; Valentina M Factor; Swayamjot Kaur; Insa S Schroeder; Frank Mercurio; Amer A Beg; Snorri S Thorgeirsson; Marcello Arsura
Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis.
Cancer research 2004;64(19):7030-8.
2004: Jennifer D Bilyeu; Ganesh R Panta; Lakita G Cavin; Christina M Barrett; Eddie J Turner; Trevor W Sweatman; Mervyn Israel; Leonard Lothstein; Marcello Arsura
Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines.
Molecular pharmacology 2004;65(4):1038-47.
2004: Ganesh R Panta; Swayamjot Kaur; Lakita G Cavin; Maria L Cortés; Frank Mercurio; Leonard Lothstein; Trevor W Sweatman; Mervyn Israel; Marcello Arsura
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Molecular and cellular biology 2004;24(5):1823-35.
2003: Lakita G Cavin; Raphaëlle Romieu-Mourez; Ganesh R Panta; Jiyuan Sun; Valentina M Factor; Snorri S Thorgeirsson; Gail E Sonenshein; Marcello Arsura
Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes.
Hepatology (Baltimore, Md.) 2003;38(6):1540-51.
2003: Marcello Arsura; Ganesh R Panta; Jennifer D Bilyeu; Lakita G Cavin; Mika A Sovak; Aundrea A Oliver; Valentina M Factor; Rainer Heuchel; Frank Mercurio; Snorri S Thorgeirsson; Gail E Sonenshein
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.
Oncogene 2003;22(3):412-25.
2001: Valentina M Factor; A L Oliver; Ganesh R Panta; Snorri S Thorgeirsson; Gail E Sonenshein; Marcello Arsura
Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice.
Hepatology (Baltimore, Md.) 2001;34(1):32-41.
2001: W Yang; J Shen; M Wu; Marcello Arsura; M FitzGerald; Z Suldan; Dong W Kim; C S Hofmann; Stefania Pianetti; Raphaëlle Romieu-Mourez; Leonard P Freedman; Gail E Sonenshein
Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.
Oncogene 2001;20(14):1688-702.
2001: Stefania Pianetti; Marcello Arsura; Raphaëlle Romieu-Mourez; R J Coffey; Gail E Sonenshein
Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.
Oncogene 2001;20(11):1287-99.
2000: Marcello Arsura; C S Hofmann; Josée Golay; Martino Introna; Gail E Sonenshein
A-myb rescues murine B-cell lymphomas from IgM-receptor-mediated apoptosis through c-myc transcriptional regulation.
Blood 2000;96(3):1013-20.
2000: Marcello Arsura; Frank Mercurio; A L Oliver; Snorri S Thorgeirsson; Gail E Sonenshein
Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells.
Molecular and cellular biology 2000;20(15):5381-91.
1999: C Torchinsky; Elizabeth Messana; Marcello Arsura; Douglas A Cotanche
Regulation of p27Kip1 during gentamicin mediated hair cell death.
Journal of neurocytology 1999;28(10-11):913-24.
1999: Mika A Sovak; Marcello Arsura; GJ Zanieski; Kathryn T Kavanagh; Gail E Sonenshein
The inhibitory effects of transforming growth factor beta1 on breast cancer cell proliferation are mediated through regulation of aberrant nuclear factor-kappaB/Rel expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(8):537-44.
1999: MJ FitzGerald; Marcello Arsura; RE Bellas; W Yang; M Wu; Lynda Chin; Koren K Mann; Ronald A DePinho; Gail E Sonenshein
Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.
Oncogene 1999;18(15):2489-98.
1997: G G Ying; Marcello Arsura; Martino Introna; Josée Golay
The DNA binding domain of the A-MYB transcription factor is responsible for its B cell-specific activity and binds to a B cell 110-kDa nuclear protein.
The Journal of biological chemistry 1997;272(40):24921-6.
1997: Marcello Arsura; MJ FitzGerald; N Fausto; Gail E Sonenshein
Nuclear factor-kappaB/Rel blocks transforming growth factor beta1-induced apoptosis of murine hepatocyte cell lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(10):1049-59.
1997: D J Marhamati; RE Bellas; Marcello Arsura; Kyriakos E Kypreos; Gail E Sonenshein
A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase.
Molecular and cellular biology 1997;17(5):2448-57.
1996: M Wu; H Lee; RE Bellas; SL Schauer; Marcello Arsura; D Katz; MJ FitzGerald; Thomas L Rothstein; D H Sherr; Gail E Sonenshein
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.
The EMBO journal 1996;15(17):4682-90.
1996: M Wu; Marcello Arsura; RE Bellas; MJ FitzGerald; H Lee; SL Schauer; D H Sherr; Gail E Sonenshein
Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells.
Molecular and cellular biology 1996;16(9):5015-25.
1996: Marcello Arsura; M Wu; Gail E Sonenshein
TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha.
Immunity 1996;5(1):31-40.
1995: Marcello Arsura; A Deshpande; S R Hann; Gail E Sonenshein
Variant Max protein, derived by alternative splicing, associates with c-Myc in vivo and inhibits transactivation.
Molecular and cellular biology 1995;15(12):6702-9.
1995: H Lee; Marcello Arsura; M Wu; Mabel P Duyao; AJ Buckler; Gail E Sonenshein
Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.
The Journal of experimental medicine 1995;181(3):1169-77.
1994: Marcello Arsura; Michele Luchetti; Eugenio Erba; Josée Golay; Alessandro Rambaldi; Martino Introna
Dissociation between p93B-myb and p75c-myb expression during the proliferation and differentiation of human myeloid cell lines.
Blood 1994;83(7):1778-90.
1994: Martino Introna; Michele Luchetti; M Castellano; Marcello Arsura; Josée Golay
The myb oncogene family of transcription factors: potent regulators of hematopoietic cell proliferation and differentiation.
Seminars in cancer biology 1994;5(2):113-24.
1994: R Schirò; Daniela Longoni; V Rossi; O Maglia; A Doni; Marcello Arsura; G Carrara; Giuseppe Masera; E Vannier; C A Dinarello
Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist.
Blood 1994;83(2):460-5.
1992: Marcello Arsura; Martino Introna; F Passerini; A Mantovani; Josée Golay
B-myb antisense oligonucleotides inhibit proliferation of human hematopoietic cell lines.
Blood 1992;79(10):2708-16.
1991: Josée Golay; Alessandro Capucci; Marcello Arsura; M Castellano; V Rizzo; Martino Introna
Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells.
Blood 1991;77(1):149-58.