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Xianlin Han

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Michael A Kiebish; Xinping Liu; David J Mancuso; Harold F Sims; Kui Yang; Zhongdan Zhao; W Todd Cade; Rebekah Cerqua; Shaoping Guan; Xianlin Han; Richard W Gross
Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome.
Rowland H Han; Xiaoling Fang; Miao Wang; Xianlin Han
Simulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis.
Gavin W Sewell; Philip J Smith; Roser Vega; Ann P Walker; Jacek Bielawski; Stuart L Bloom; Victoria Goss; Xianlin Han; Yusuf A Hannun; Grielof Koster; Anthony D Postle; Farooq Z Rahman; Anthony W Segal
Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition.

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2013: Michael A Kiebish; Xinping Liu; David J Mancuso; Harold F Sims; Kui Yang; Zhongdan Zhao; W Todd Cade; Rebekah Cerqua; Shaoping Guan; Xianlin Han; Richard W Gross
Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome.
Journal of lipid research 2013;54(5):1312-25.
2013: Rowland H Han; Xiaoling Fang; Miao Wang; Xianlin Han
Simulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis.
Journal of lipid research 2013;54(4):1023-32.
2012: Gavin W Sewell; Philip J Smith; Roser Vega; Ann P Walker; Jacek Bielawski; Stuart L Bloom; Victoria Goss; Xianlin Han; Yusuf A Hannun; Grielof Koster; Anthony D Postle; Farooq Z Rahman; Anthony W Segal
Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition.
The international journal of biochemistry & cell biology 2012;44(11):1839-46.
2012: Todd E Fox; Thomas Gardner; Xianlin Han; Michelle M Pedersen; Megan M Young; Mark Kester
Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death.
Investigative ophthalmology & visual science 2012;53(11):7257-67.
2012: Michael A Kiebish; Xinping Liu; david mancuso; Harold F Sims; Kui Yang; Zhongdan Zhao; Dana R Abendschein; Shaoping Guan; Xianlin Han; Christopher M Jenkins; Richard W Gross
Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.
The Journal of biological chemistry 2012;287(30):25086-97.
2012: Peggy P Ho; Eun Mi Hur; Amanda M Johnson; Jennifer L Kanter; Mohsen Khademi; Tobias Kind; Tamsin M Lindstrom; Laura Y Matloff; Sirisha Narayana; Tomas Olsson; Timothy M Purdy; Eun-Ju Chang; Oliver Fiehn; May H Han; Xianlin Han; Zhigang He; Hrishikesh K Srinagesh; Lawrence Steinman; Keith van Haren; William R Wikoff; William H Robinson
Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation.
Science translational medicine 2012;4(137):137ra73.
2012: Miao Wang; Huafeng Fang; Xianlin Han
Shotgun lipidomics analysis of 4-hydroxyalkenal species directly from lipid extracts after one-step in situ derivatization.
Analytical chemistry 2012;84(10):4580-6.
2012: Kourosh Zarringhalam; Lu Zhang; Richard W Gross; Xianlin Han; Michael A Kiebish; Kui Yang; Jeffrey Chuang
Statistical analysis of the processes controlling choline and ethanolamine glycerophospholipid molecular species composition.
PloS one 2012;7(5):e37293.
2011: Kui Yang; Xiaoling Fang; Richard W Gross; Xianlin Han
A practical approach for determination of mass spectral baselines.
Journal of the American Society for Mass Spectrometry 2011;22(11):2090-9.
2011: Naoki Kumashiro; Kitt Falk Petersen; Varman T Samuel; Sara A Beddow; Xin Chu; James Dziura; Derek M Erion; Glenn S Gerhard; Xianlin Han; Mario Kahn; Christopher D Still; Dongyan Zhang; Gerald I Shulman
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16381-5.
2011: Kathleen A Potter; Michael J Kern; G Fullbright; Jacek Bielawski; Steven S Scherer; Sabrina W Yum; Jian J Li; Hua Cheng; Xianlin Han; Jagadish Kummetha Venkata; Bärbel Rohrer; P Akbar Ali Khan; Hiroko Hama
Central nervous system dysfunction in a mouse model of FA2H deficiency.
Glia 2011;59(7):1009-21.
2011: Kui Yang; Zhongdan Zhao; Richard W Gross; Xianlin Han
Identification and quantitation of unsaturated fatty acid isomers by electrospray ionization tandem mass spectrometry: a shotgun lipidomics approach.
Analytical chemistry 2011;83(11):4243-50.
2011: Rima Kaddurah-Daouk; Steve Rozen; Wayne Matson; Xianlin Han; Christine M Hulette; James R Burke; P Murali Doraiswamy; Kathleen A Welsh-Bohmer
Metabolomic changes in autopsy-confirmed Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(3):309-17.
2011: Charles A Harris; Joel T Haas; Ryan S Streeper; Scot J Stone; Manju Kumari; Kui Yang; Xianlin Han; Nicholas Brownell; Richard W Gross; Rudolf Zechner; Robert V Farese
DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes.
Journal of lipid research 2011;52(4):657-67.
2011: Richard W Gross; Xianlin Han
Lipidomics at the interface of structure and function in systems biology.
Chemistry & biology 2011;18(3):284-91.
2011: Steven M Claypool; Kevin Whited; Santi Srijumnong; Xianlin Han; Carla M Koehler
Barth syndrome mutations that cause tafazzin complex lability.
The Journal of cell biology 2011;192(3):447-62.
2011: Xianlin Han; Caroline Hellegers; Steve Rozen; Kathleen A Welsh-Bohmer; Stephen H Boyle; James R Burke; Hua Cheng; P Murali Doraiswamy; Rima Kaddurah-Daouk
Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.
PloS one 2011;6(7):e21643.
2011: Lu Zhang; Robert J A Bell; Richard W Gross; Xianlin Han; Michael A Kiebish; Thomas N Seyfried; Jeffrey H Chuang
A mathematical model for the determination of steady-state cardiolipin remodeling mechanisms using lipidomic data.
PloS one 2011;6(6):e21170.
2010: Qiang Liu; Justin Trotter; Juan Zhang; Melinda M Peters; Hua Cheng; Jianxin Bao; Xianlin Han; Edwin J Weeber; Guojun Bu
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(50):17068-78.
2010: David J Mancuso; Harold F Sims; Kui Yang; Michael A Kiebish; Xiong Su; Christopher M Jenkins; Shaoping Guan; Sung Ho Moon; Terri Pietka; Fatiha Nassir; Timothy Schappe; Kristin Moore; Xianlin Han; Nada A Abumrad; Richard W Gross
Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
The Journal of biological chemistry 2010;285(47):36495-510.
2010: J Mark Brown; Jenna L Betters; Caleb Lord; Yinyan Ma; Xianlin Han; Kui Yang; Heather M Alger; John Melchior; Janet Sawyer; Ramesh Shah; Martha Wilson; Xiuli Liu; Mark J Graham; Richard Lee; Rosanne M Crooke; Gerald I Shulman; Bingzhong Xue; Hang Shi; Liqing Yu
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance.
Journal of lipid research 2010;51(11):3306-15.
2010: Xianlin Han; Changwei Liu; Bao Liu; Wei Ye; Weiwei Wu
[Preliminary research of endothelial growth stimulation of 125I-vascular endothelial growth factor-coated artificial vascular patch].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 2010;24(9):1047-51.
2010: Marian C Cheung; Tomás Vaisar; Xianlin Han; Jay W Heinecke; John J Albers
Phospholipid transfer protein in human plasma associates with proteins linked to immunity and inflammation.
Biochemistry 2010;49(34):7314-22.
2010: Jia Li; Caroline Romestaing; Xianlin Han; Yuan Li; Xinbao Hao; Yinyuan Wu; Chao Sun; Xiaolei Liu; Leonard S Jefferson; Jingwei Xiong; Kathryn F Lanoue; Zhijie Chang; Christopher J Lynch; Huayan Wang; Yuguang Shi
Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
Cell metabolism 2010;12(2):154-65.
2010: Michael A Kiebish; Rob Bell; Kui Yang; Toan Phan; Zhongdan Zhao; William Ames; Thomas N Seyfried; Richard W Gross; Jeffrey H Chuang; Xianlin Han
Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics.
Journal of lipid research 2010;51(8):2153-70.
2010: Xianlin Han
Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease.
Biochimica et biophysica acta 2010;1801(8):774-83.
2010: Hua Cheng; Yunhua Zhou; David M Holtzman; Xianlin Han
Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease.
Neurobiology of aging 2010;31(7):1188-96.
2010: Hua Cheng; Gang Sun; Kui Yang; Richard W Gross; Xianlin Han
Selective desorption/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix.
Journal of lipid research 2010;51(6):1599-609.
2010: Xianlin Han
The pathogenic implication of abnormal interaction between apolipoprotein E isoforms, amyloid-beta peptides, and sulfatides in Alzheimer's disease.
Molecular neurobiology 2010;41(2-3):97-106.
2010: Hongping Ye; John Hill; John Kauffman; Xianlin Han
Qualitative and quantitative comparison of brand name and generic protein pharmaceuticals using isotope tags for relative and absolute quantification and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry.
Analytical biochemistry 2010;400(1):46-55.
2010: Laleh Saadat; Jeffrey L Dupree; John Kilkus; Xianlin Han; Maria Traka; Richard L Proia; Glyn Dawson; Brian Popko
Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice.
Glia 2010;58(4):391-8.
2010: Chunxiu Hu; Miriam Hoene; Xinjie Zhao; Hans U Häring; Erwin Schleicher; Rainer Lehmann; Xianlin Han; Guowang Xu; Cora Weigert
Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated fatty acids after one bout of exercise in mice.
PloS one 2010;5(10):e13318.
2009: david mancuso; PT Kotzbauer; David F Wozniak; Harold F Sims; Christopher M Jenkins; Shaoping Guan; Xianlin Han; Kui Yang; Gang Sun; Ibrahim Malik; Sara Conyers; Karen G Green; Robert E Schmidt; Richard W Gross
Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.
The Journal of biological chemistry 2009;284(51):35632-44.
2009: Xianlin Han
Lipidomics: developments and applications.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2663.
2009: Kui Yang; Zhongdan Zhao; Richard W Gross; Xianlin Han
Systematic analysis of choline-containing phospholipids using multi-dimensional mass spectrometry-based shotgun lipidomics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2924-36.
2009: Richard W Gross; Xianlin Han
Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseases.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E297-303.
2009: Kui Yang; Hua Cheng; Richard W Gross; Xianlin Han
Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics.
Analytical chemistry 2009;81(11):4356-68.
2009: Matthew C Gropler; Thurl E Harris; Angela M Hall; Nathan E Wolins; Richard W Gross; Xianlin Han; Zhouji Chen; Brian N Finck
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
The Journal of biological chemistry 2009;284(11):6763-72.
2009: Uma Vempati; Xianlin Han; Carlos T Moraes
Lack of cytochrome c in mouse fibroblasts disrupts assembly/stability of respiratory complexes I and IV.
The Journal of biological chemistry 2009;284(7):4383-91.
2009: Sarah E Gale; Emily J Westover; Nicole Dudley; Kathiresan Krishnan; Sean Merlin; David E Scherrer; Xianlin Han; Xiuhong Zhai; Howard L Brockman; Rhoderick E Brown; Douglas F Covey; Jean E Schaffer; Paul Schlesinger; Daniel S Ory
Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.
The Journal of biological chemistry 2009;284(3):1755-64.
2009: Michael A Kiebish; Xianlin Han; Thomas N Seyfried
Examination of the brain mitochondrial lipidome using shotgun lipidomics.
Methods in molecular biology (Clifton, N.J.) 2009;579():3-18.
2009: Michael A Kiebish; Xianlin Han; Hua Cheng; Thomas N Seyfried
In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours.
ASN neuro 2009;1(3):.
2008: Michael A Kiebish; Xianlin Han; Hua Cheng; Jeffrey H Chuang; Thomas N Seyfried
Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer.
Journal of lipid research 2008;49(12):2545-56.
2008: Gang Sun; Kui Yang; Zhongdan Zhao; Shaoping Guan; Xianlin Han; Richard W Gross
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cellular glycerophospholipids enabled by multiplexed solvent dependent analyte-matrix interactions.
Analytical chemistry 2008;80(19):7576-85.
2008: Michael A Kiebish; Xianlin Han; Hua Cheng; Jeffrey H Chuang; Thomas N Seyfried
Brain mitochondrial lipid abnormalities in mice susceptible to spontaneous gliomas.
Lipids 2008;43(10):951-9.
2008: Hongping Ye; John Hill; John Kauffman; Connie Gryniewicz; Xianlin Han
Detection of protein modifications and counterfeit protein pharmaceuticals using isotope tags for relative and absolute quantification and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry: studies of insulins.
Analytical biochemistry 2008;379(2):182-91.
2008: John P Kilkus; Rajendra Goswami; Sylvia A Dawson; Fernando Daniel Testai; Evgeny Berdyshev; Xianlin Han; Glyn Dawson
Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons.
Journal of neurochemistry 2008;106(4):1745-57.
2008: Youchun Zeng; Xianlin Han
Sulfatides facilitate apolipoprotein E-mediated amyloid-beta peptide clearance through an endocytotic pathway.
Journal of neurochemistry 2008;106(3):1275-86.
2008: Ying Sun; David P Witte; Huimin Ran; Matt Zamzow; Sonya Barnes; hua cheng; Xianlin Han; Michael T Williams; Matthew R Skelton; Charles V Vorhees; Gregory A Grabowski
Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice.
Human molecular genetics 2008;17(15):2345-56.
2008: Dusica Maysinger; Michael Holmes; Xianlin Han; Richard M Epand; Evi Pertens; Anne Foerster; Cia Barlas; David M Holtzman; Jack Diamond
Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(31):7891-9.
2008: Xianlin Han; Kui Yang; Richard W Gross
Microfluidics-based electrospray ionization enhances the intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry: development of an automated high-throughput platform for shotgun lipidomics.
Rapid communications in mass spectrometry : RCM 2008;22(13):2115-24.
2008: John J Lehman; Sihem Boudina; Natasha Hausler Banke; Nandakumar Sambandam; Xianlin Han; Deanna M Young; Teresa C Leone; Richard W Gross; E Douglas Lewandowski; E Dale Abel; Daniel P Kelly
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H185-96.
2008: Michael A Kiebish; Xianlin Han; hua cheng; Adam Lunceford; Catherine F Clarke; Hwi Moon; Jeffrey H Chuang; Thomas N Seyfried
Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria.
Journal of neurochemistry 2008;106(1):299-312.
2008: hua cheng; david mancuso; Xuntian Jiang; Shaoping Guan; Jingyue Yang; Kui Yang; Gang Sun; Richard W Gross; Xianlin Han
Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling.
Biochemistry 2008;47(21):5869-80.
2008: Youchun Zeng; hua cheng; Xuntian Jiang; Xianlin Han
Endosomes and lysosomes play distinct roles in sulfatide-induced neuroblastoma apoptosis: potential mechanisms contributing to abnormal sulfatide metabolism in related neuronal diseases.
The Biochemical journal 2008;410(1):81-92.
2007: Xuntian Jiang; hua cheng; Kui Yang; Richard W Gross; Xianlin Han
Alkaline methanolysis of lipid extracts extends shotgun lipidomics analyses to the low-abundance regime of cellular sphingolipids.
Analytical biochemistry 2007;371(2):135-45.
2007: Xianlin Han
An update on lipidomics: progress and application in biomarker and drug development.
Current opinion in molecular therapeutics 2007;9(6):586-91.
2007: Eileen M Burkart; Nandakumar Sambandam; Xianlin Han; Richard W Gross; Michael Courtois; Carolyn M Gierasch; Kooresh Shoghi; Michael J Welch; Daniel P Kelly
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart.
The Journal of clinical investigation 2007;117(12):3930-9.
2007: david mancuso; Harold F Sims; Xianlin Han; Christopher M Jenkins; Shao Ping Guan; Kui Yang; Sung Ho Moon; Terri Pietka; Nada A Abumrad; Paul H Schlesinger; Richard W Gross
Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
The Journal of biological chemistry 2007;282(48):34611-22.
2007: Xianlin Han
Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer's disease: a tale of shotgun lipidomics.
Journal of neurochemistry 2007;103 Suppl 1():171-9.
2007: Chun-Lin Chen; I-Hua Liu; Steven J Fliesler; Xianlin Han; Shuan Shian Huang; Jung San Huang
Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis.
Journal of cell science 2007;120(Pt 20):3509-21.
2007: Gang Sun; Kui Yang; Zhongdan Zhao; Shaoping Guan; Xianlin Han; Richard W Gross
Shotgun metabolomics approach for the analysis of negatively charged water-soluble cellular metabolites from mouse heart tissue.
Analytical chemistry 2007;79(17):6629-40.
2007: Fatiha Nassir; Brody Wilson; Xianlin Han; Richard W Gross; Nada A Abumrad
CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine.
The Journal of biological chemistry 2007;282(27):19493-501.
2007: Xianlin Han; Jingyue Yang; Kui Yang; Zhongdan Zhao; Dana R Abendschein; Richard W Gross
Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes: a shotgun lipidomics study.
Biochemistry 2007;46(21):6417-28.
2007: Maho Morishima-Kawashima; Xianlin Han; Yu Tanimura; Hiroki Hamanaka; Mariko Kobayashi; Takashi Sakurai; Minesuke Yokoyama; Koji Wada; Nobuyuki Nukina; Shinobu C Fujita; Yasuo Ihara
Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains.
Journal of neurochemistry 2007;101(4):949-58.
2007: John Yang; Nandakumar Sambandam; Xianlin Han; Richard W Gross; Michael Courtois; Attila Kovacs; Maria Febbraio; Brian N Finck; Daniel P Kelly
CD36 deficiency rescues lipotoxic cardiomyopathy.
Circulation research 2007;100(8):1208-17.
2007: hua cheng; Xuntian Jiang; Xianlin Han
Alterations in lipid homeostasis of mouse dorsal root ganglia induced by apolipoprotein E deficiency: a shotgun lipidomics study.
Journal of neurochemistry 2007;101(1):57-76.
2007: david mancuso; Xianlin Han; Christopher M Jenkins; John J Lehman; Nandakumar Sambandam; Harold F Sims; Jingyue Yang; Wei Yan; Kui Yang; Karen Green; Dana R Abendschein; Jeffrey E Saffitz; Richard W Gross
Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
The Journal of biological chemistry 2007;282(12):9216-27.
2007: Kui Yang; Zhongdan Zhao; Richard W Gross; Xianlin Han
Shotgun lipidomics identifies a paired rule for the presence of isomeric ether phospholipid molecular species.
PloS one 2007;2(12):e1368.
2007: Richard W Gross; Xianlin Han
Lipidomics in diabetes and the metabolic syndrome.
Methods in enzymology 2007;433():73-90.
2007: Xuntian Jiang; Daniel S Ory; Xianlin Han
Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine.
Rapid communications in mass spectrometry : RCM 2007;21(2):141-52.
2007: Xianlin Han
Neurolipidomics: challenges and developments.
Frontiers in bioscience : a journal and virtual library 2007;12():2601-15.
2006: Todd E Fox; Xianlin Han; Samuel Kelly; Alfred H Merrill; Rex E Martin; Robert E Anderson; Thomas Gardner; Mark Kester
Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy.
Diabetes 2006;55(12):3573-80.
2006: Nica M Borradaile; Xianlin Han; Jeffrey D Harp; Sarah E Gale; Daniel S Ory; Jean E Schaffer
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death.
Journal of lipid research 2006;47(12):2726-37.
2006: Miki Hiraoka; Akira Abe; Ye Lu; Kui Yang; Xianlin Han; Richard W Gross; James A Shayman
Lysosomal phospholipase A2 and phospholipidosis.
Molecular and cellular biology 2006;26(16):6139-48.
2006: Xuntian Jiang; Xianlin Han
Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach.
Journal of lipid research 2006;47(8):1865-73.
2006: hua cheng; Shaoping Guan; Xianlin Han
Abundance of triacylglycerols in ganglia and their depletion in diabetic mice: implications for the role of altered triacylglycerols in diabetic neuropathy.
Journal of neurochemistry 2006;97(5):1288-300.
2006: Sarah E Gale; Andrey Frolov; Xianlin Han; Perry E Bickel; Li Cao; Anne M Bowcock; Jean E Schaffer; Daniel S Ory
A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.
The Journal of biological chemistry 2006;281(16):11082-9.
2006: Xianlin Han; Kui Yang; Jingyue Yang; hua cheng; Richard W Gross
Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples.
Journal of lipid research 2006;47(4):864-79.
2006: Xianlin Han; Kui Yang; Jingyue Yang; Kora N Fikes; hua cheng; Richard W Gross
Factors influencing the electrospray intrasource separation and selective ionization of glycerophospholipids.
Journal of the American Society for Mass Spectrometry 2006;17(2):264-74.
2005: Xianlin Han; Jingyue Yang; hua cheng; Kui Yang; Dana R Abendschein; Richard W Gross
Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking altered substrate utilization with mitochondrial dysfunction.
Biochemistry 2005;44(50):16684-94.
2005: Jingyue Yang; Beverly Gibson; Jacqueline Snider; Christopher M Jenkins; Xianlin Han; Richard W Gross
Submicromolar concentrations of palmitoyl-CoA specifically thioesterify cysteine 244 in glyceraldehyde-3-phosphate dehydrogenase inhibiting enzyme activity: a novel mechanism potentially underlying fatty acid induced insulin resistance.
Biochemistry 2005;44(35):11903-12.
2005: Richard W Gross; Christopher M Jenkins; Jingyue Yang; david mancuso; Xianlin Han
Functional lipidomics: the roles of specialized lipids and lipid-protein interactions in modulating neuronal function.
Prostaglandins & other lipid mediators 2005;77(1-4):52-64.
2005: Linda J Pike; Xianlin Han; Richard W Gross
Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study.
The Journal of biological chemistry 2005;280(29):26796-804.
2005: Wei Yan; Christopher M Jenkins; Xianlin Han; david mancuso; Harold F Sims; Kui Yang; Richard W Gross
The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.
The Journal of biological chemistry 2005;280(29):26669-79.
2005: Xianlin Han; Kui Yang; hua cheng; Kora N Fikes; Richard W Gross
Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization.
Journal of lipid research 2005;46(7):1548-60.
2005: Xianlin Han; Richard W Gross
Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples.
Mass spectrometry reviews 2005;24(3):367-412.
2005: Xiong Su; Xianlin Han; david mancuso; Dana R Abendschein; Richard W Gross
Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics.
Biochemistry 2005;44(13):5234-45.
2005: Xianlin Han; Richard W Gross
Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes.
Expert review of proteomics 2005;2(2):253-64.
2005: Hsiu-Chiang Chiu; Attila Kovacs; Robert M Blanton; Xianlin Han; Michael Courtois; Carla Weinheimer; Kathryn A Yamada; Sylvain Brunet; Haodong Xu; Jeanne M Nerbonne; Michael J Welch; Nicole M Fettig; Terry L Sharp; Nandakumar Sambandam; Krista M Olson; Daniel S Ory; Jean E Schaffer
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy.
Circulation research 2005;96(2):225-33.
2005: Xianlin Han
Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: implication of the role of lipids in the pathogenesis of Alzheimer's disease.
Current Alzheimer research 2005;2(1):65-77.
2005: Xianlin Han; hua cheng
Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics.
Journal of lipid research 2005;46(1):163-75.
2004: Xianlin Han; hua cheng; david mancuso; Richard W Gross
Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium.
Biochemistry 2004;43(49):15584-94.
2004: Suzanne E Wahrle; Hong Jiang; Maia Parsadanian; Justin Legleiter; Xianlin Han; John D Fryer; Tomasz Kowalewski; David M Holtzman
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.
The Journal of biological chemistry 2004;279(39):40987-93.
2004: Xianlin Han
The role of apolipoprotein E in lipid metabolism in the central nervous system.
Cellular and molecular life sciences : CMLS 2004;61(15):1896-906.
2004: Xianlin Han; Jingyue Yang; hua cheng; Hongping Ye; Richard W Gross
Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry.
Analytical biochemistry 2004;330(2):317-31.
2004: Xiong Su; Xianlin Han; Jingyue Yang; david mancuso; Jeannie Chen; Perry E Bickel; Richard W Gross
Sequential ordered fatty acid alpha oxidation and Delta9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes.
Biochemistry 2004;43(17):5033-44.
2004: Jiunn-Tay Lee; Jan Xu; Jin-Moo Lee; Grace Ku; Xianlin Han; Ding-I Yang; Shawei Chen; Chung Y Hsu
Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.
The Journal of cell biology 2004;164(1):123-31.
2003: Elizabeth P Newberry; Yan Xie; Susan Kennedy; Xianlin Han; Kimberly Buhman; Jianyang Luo; Richard W Gross; Nicholas O Davidson
Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene.
The Journal of biological chemistry 2003;278(51):51664-72.
2003: Christopher M Jenkins; Xianlin Han; Jingyue Yang; david mancuso; Harold F Sims; Anthony J Muslin; Richard W Gross
Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis.
Biochemistry 2003;42(40):11798-807.
2003: Jingyue Yang; Xianlin Han; Richard W Gross
Identification of hepatic peroxisomal phospholipase A(2) and characterization of arachidonic acid-containing choline glycerophospholipids in hepatic peroxisomes.
FEBS letters 2003;546(2-3):247-50.
2003: hua cheng; J Xu; Daniel W McKeel; Xianlin Han
Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study.
Cellular and molecular biology (Noisy-le-Grand, France) 2003;49(5):809-18.
2003: Xianlin Han; Anne M Fagan; hua cheng; John C Morris; Chengjie Xiong; David M Holtzman
Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia.
Annals of neurology 2003;54(1):115-9.
2003: david mancuso; Dana R Abendschein; Christopher M Jenkins; Xianlin Han; Jeffrey E Saffitz; Richard B Schuessler; Richard W Gross
Cardiac ischemia activates calcium-independent phospholipase A2beta, precipitating ventricular tachyarrhythmias in transgenic mice: rescue of the lethal electrophysiologic phenotype by mechanism-based inhibition.
The Journal of biological chemistry 2003;278(25):22231-6.
2003: Xianlin Han; Richard W Gross
Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics.
Journal of lipid research 2003;44(6):1071-9.
2003: Laura L Listenberger; Xianlin Han; Sarah E Lewis; Sylvaine Cases; Robert V Farese; Daniel S Ory; Jean E Schaffer
Triglyceride accumulation protects against fatty acid-induced lipotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3077-82.
2003: Usha Acharya; Shetal Patel; Edmund J Koundakjian; Kunio Nagashima; Xianlin Han; Jairaj K Acharya
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.
Science (New York, N.Y.) 2003;299(5613):1740-3.
2003: Xianlin Han; hua cheng; John D Fryer; Anne M Fagan; David M Holtzman
Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content.
The Journal of biological chemistry 2003;278(10):8043-51.
2003: Brian N Finck; Xianlin Han; Michael Courtois; Franck Aimond; Jeanne M Nerbonne; Attila Kovacs; Richard W Gross; Daniel P Kelly
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1226-31.
2002: Masaaki Narita; David M Holtzman; Anne M Fagan; Mary Jo Ladu; Li Yu; Xianlin Han; Richard W Gross; Guojun Bu; Alan L Schwartz
Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein.
Journal of biochemistry 2002;132(5):743-9.
2002: Paul E Glaser; Xianlin Han; Richard W Gross
Tubulin is the endogenous inhibitor of the glyceraldehyde 3-phosphate dehydrogenase isoform that catalyzes membrane fusion: Implications for the coordinated regulation of glycolysis and membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14104-9.
2002: Christopher M Jenkins; Xianlin Han; david mancuso; Richard W Gross
Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s.
The Journal of biological chemistry 2002;277(36):32807-14.
2002: Xianlin Han; David M Holtzman; Daniel W McKeel; John Kelley; John C Morris
Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis.
Journal of neurochemistry 2002;82(4):809-18.
2002: Xianlin Han
Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry.
Analytical biochemistry 2002;302(2):199-212.
2002: Linda J Pike; Xianlin Han; Koong-Nah Chung; Richard W Gross
Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis.
Biochemistry 2002;41(6):2075-88.
2002: Brian N Finck; John J Lehman; Teresa C Leone; Michael J Welch; Michael J Bennett; Attila Kovacs; Xianlin Han; Richard W Gross; Ray Kozak; Gary D Lopaschuk; Daniel P Kelly
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
The Journal of clinical investigation 2002;109(1):121-30.
2001: Ronald B DeMattos; Robert P Brendza; John Edward Heuser; M Kierson; John R Cirrito; J Fryer; Patrick M. Sullivan; Anne M Fagan; Xianlin Han; David M Holtzman
Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice.
Neurochemistry international 2001;39(5-6):415-25.
2001: Xianlin Han; Richard W Gross
Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry.
Analytical biochemistry 2001;295(1):88-100.
2001: Xianlin Han; David M Holtzman; D W McKeel
Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry.
Journal of neurochemistry 2001;77(4):1168-80.
2000: Xianlin Han; Dana R Abendschein; J G Kelley; Richard W Gross
Diabetes-induced changes in specific lipid molecular species in rat myocardium.
The Biochemical journal 2000;352 Pt 1():79-89.
1999: Y Zeng; Xianlin Han; R W Gross
Phospholipid-subclass-specific partitioning of lipophilic ions in membrane-water systems.
The Biochemical journal 1999;338 ( Pt 3)():651-8.
1998: Xianlin Han; Sasanka Ramanadham; J Turk; Richard W Gross
Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes: catalysis by a protein constituent recognized by monoclonal antibodies directed against glyceraldehyde-3-phosphate dehydrogenase.
Biochimica et biophysica acta 1998;1414(1-2):95-107.
1998: Y Zeng; Xianlin Han; P Schlesinger; Richard W Gross
Nonesterified fatty acids induce transmembrane monovalent cation flux: host-guest interactions as determinants of fatty acid-induced ion transport.
Biochemistry 1998;37(26):9497-508.
1998: Y Zeng; Xianlin Han; Richard W Gross
Phospholipid subclass specific alterations in the passive ion permeability of membrane bilayers: separation of enthalpic and entropic contributions to transbilayer ion flux.
Biochemistry 1998;37(8):2346-55.