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Dorothy Hanck

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TOP 3
Gregory M Lipkind; Harry A Fozzard; Dorothy A Hanck
A molecular model of the inner pore of the Ca channel in its open state.
Dongdong Li; Jessica A Loweth; Elena Nikitina; Abraham A Palmer; Nancy Bubula; Dorothy A Hanck; Stacy Herrera; Paul Vezina
Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.
Harry A Fozzard; Michael F Sheets; Dorothy A Hanck
The sodium channel as a target for local anesthetic drugs.

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All Publications

2011: Gregory M Lipkind; Harry A Fozzard; Dorothy A Hanck
A molecular model of the inner pore of the Ca channel in its open state.
Channels (Austin, Tex.) 2011;5(6):482-8.
2011: Dongdong Li; Jessica A Loweth; Elena Nikitina; Abraham A Palmer; Nancy Bubula; Dorothy A Hanck; Stacy Herrera; Paul Vezina
Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.
Journal of neurochemistry 2011;118(2):237-47.
2011: Harry A Fozzard; Michael F Sheets; Dorothy A Hanck
The sodium channel as a target for local anesthetic drugs.
Frontiers in pharmacology 2011;2():68.
2011: Michael F Sheets; Tiehua Chen; Dorothy A Hanck
Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.
Pflügers Archiv : European journal of physiology 2011;461(1):91-7.
2010: Gabrielle B Edgerton; Kenneth M Blumenthal; Dorothy A Hanck
Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.
Toxicon : official journal of the International Society on Toxinology 2010;56(4):624-36.
2010: Harry Fozzard; Dorothy A Hanck
In memoriam. Morton Arnsdorf: 1940-2010.
Circulation research 2010;107(4):446-7.
2010: Michael F Sheets; Harry A Fozzard; Gregory M Lipkind; Dorothy A Hanck
Sodium channel molecular conformations and antiarrhythmic drug affinity.
Trends in cardiovascular medicine 2010;20(1):16-21.
2009: Dorothy A Hanck; Elena Nikitina; Megan M McNulty; Harry A Fozzard; Gregory M Lipkind; Michael F Sheets
Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
Circulation research 2009;105(5):492-9.
2008: Gabrielle B Edgerton; Kenneth M Blumenthal; Dorothy A Hanck
Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.
Toxicon : official journal of the International Society on Toxinology 2008;52(3):489-500.
2008: John W Kyle; Peter J Minogue; Bettina C Thomas; Denise A Lopez Domowicz; Viviana M Berthoud; Dorothy A Hanck; Eric C Beyer
An intact connexin N-terminus is required for function but not gap junction formation.
Journal of cell science 2008;121(Pt 16):2744-50.
2008: Katie C Bittner; Dorothy A Hanck
The relationship between single-channel and whole-cell conductance in the T-type Ca2+ channel CaV3.1.
Biophysical journal 2008;95(2):931-41.
2007: Michael F Sheets; Dorothy A Hanck
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
The Journal of physiology 2007;582(Pt 1):317-34.
2007: Megan M McNulty; Gabrielle B Edgerton; Ravi D Shah; Dorothy A Hanck; Harry A Fozzard; Gregory M Lipkind
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
The Journal of physiology 2007;581(Pt 2):741-55.
2007: Dorothy A Hanck; Michael F Sheets
Site-3 toxins and cardiac sodium channels.
Toxicon : official journal of the International Society on Toxinology 2007;49(2):181-93.
2006: Megan M McNulty; John W Kyle; Gregory M Lipkind; Dorothy A Hanck
An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.
Molecular pharmacology 2006;70(5):1514-23.
2006: A Khan; John W Kyle; Dorothy A Hanck; Gregory M Lipkind; Harry A Fozzard
Isoform-dependent interaction of voltage-gated sodium channels with protons.
The Journal of physiology 2006;576(Pt 2):493-501.
2006: Benjamin S Freeze; Megan M McNulty; Dorothy A Hanck
State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel.
Molecular pharmacology 2006;70(2):718-26.
2006: Mark C Emerick; Rebecca Stein; Robin Kunze; Megan M McNulty; Melissa R Regan; Dorothy A Hanck; William S Agnew
Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations.
Proteins 2006;64(2):320-42.
2006: Xiaoli Zhong; Jinrong R Liu; John W Kyle; Dorothy A Hanck; William S Agnew
A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies.
Human molecular genetics 2006;15(9):1497-512.
2005: Alice D Lam; Maria D Chikina; Megan M McNulty; Ian W Glaaser; Dorothy A Hanck
Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels.
Pflügers Archiv : European journal of physiology 2005;451(2):349-61.
2005: Michael F Sheets; Dorothy A Hanck
Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation.
The Journal of physiology 2005;563(Pt 1):83-93.
2004: Akihiko Sunami; Arlene Tracey; Ian W Glaaser; Gregory M Lipkind; Dorothy A Hanck; Harry A Fozzard
Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.
The Journal of physiology 2004;561(Pt 2):403-13.
2004: Megan M McNulty; Dorothy A Hanck
State-dependent mibefradil block of Na+ channels.
Molecular pharmacology 2004;66(6):1652-61.
2004: Michael C Puljung; Viviana M Berthoud; Eric C Beyer; Dorothy A Hanck
Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.
The Journal of general physiology 2004;124(5):587-603.
2004: Anna L Seibert; Jinrong Liu; Dorothy A Hanck; Kenneth M Blumenthal
Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3.
Biochemistry 2004;43(22):7082-9.
2003: Anna L Seibert; Jinrong Liu; Dorothy A Hanck; Kenneth M Blumenthal
Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity.
Biochemistry 2003;42(49):14515-21.
2003: Michael F Sheets; Dorothy A Hanck
Molecular action of lidocaine on the voltage sensors of sodium channels.
The Journal of general physiology 2003;121(2):163-75.
2002: Michael F Sheets; Dorothy A Hanck
The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.
Biophysical journal 2002;82(6):3048-55.
2000: R L Martin; B Pittendrigh; J Liu; Robert Reenan; Richard H ffrench-Constant; Dorothy A Hanck
Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin.
Insect biochemistry and molecular biology 2000;30(11):1051-9.
2000: R L Martin; J H Lee; Leanne L Cribbs; Edward Perez-Reyes; Dorothy A Hanck
Mibefradil block of cloned T-type calcium channels.
The Journal of pharmacology and experimental therapeutics 2000;295(1):302-8.
2000: Michael F Sheets; John W Kyle; Dorothy A Hanck
The role of the putative inactivation lid in sodium channel gating current immobilization.
The Journal of general physiology 2000;115(5):609-20.
2000: Dorothy A Hanck; Jonathan C Makielski; Michael F Sheets
Lidocaine alters activation gating of cardiac Na channels.
Pflügers Archiv : European journal of physiology 2000;439(6):814-21.
1999: Michael F Sheets; John W Kyle; RG Kallen; Dorothy A Hanck
The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.
Biophysical journal 1999;77(2):747-57.
1999: G Richard Benzinger; G S Tonkovich; Dorothy A Hanck
Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents.
The Journal of general physiology 1999;113(2):333-46.
1999: Michael F Sheets; Dorothy A Hanck
Gating of skeletal and cardiac muscle sodium channels in mammalian cells.
The Journal of physiology 1999;514 ( Pt 2)():425-36.
1998: Dorothy A Hanck
Heartthrobs.
Science (New York, N.Y.) 1998;279(5353):1004.
1998: G R Benzinger; John W Kyle; Kenneth M Blumenthal; Dorothy A Hanck
A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.
The Journal of biological chemistry 1998;273(1):80-4.
1998: M M Millonas; Dorothy A Hanck
Nonequilibrium response spectroscopy of voltage-sensitive ion channel gating.
Biophysical journal 1998;74(1):210-29.
1997: G R Benzinger; Chester L Drum; L Q Chen; RG Kallen; D A Hanck; Dorothy A Hanck
Differences in the binding sites of two site-3 sodium channel toxins.
Pflügers Archiv : European journal of physiology 1997;434(6):742-9.
1996: G J Kelso; Chester L Drum; Dorothy A Hanck; K M Blumenthal
Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
Biochemistry 1996;35(45):14157-64.
1996: B L Dias-Kadambi; K A Combs; Chester L Drum; Dorothy A Hanck; K M Blumenthal
The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B.
The Journal of biological chemistry 1996;271(39):23828-35.
1996: Michael F Sheets; J W Kyle; S Krueger; Dorothy A Hanck
Optimization of a mammalian expression system for the measurement of sodium channel gating currents.
The American journal of physiology 1996;271(3 Pt 1):C1001-6.
1996: H A Fozzard; Dorothy A Hanck
Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.
Physiological reviews 1996;76(3):887-926.
1996: D Zeng; J W Kyle; R L Martin; K S Ambler; Dorothy A Hanck
Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.
The American journal of physiology 1996;270(5 Pt 1):C1522-31.
1996: B L Dias-Kadambi; Chester L Drum; Dorothy A Hanck; K M Blumenthal
Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
The Journal of biological chemistry 1996;271(16):9422-8.
1995: Michael F Sheets; Dorothy A Hanck
Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.
The Journal of general physiology 1995;106(4):617-40.
1995: Dorothy A Hanck; Michael F Sheets
Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin.
The Journal of general physiology 1995;106(4):601-16.
1995: Gregory M Lipkind; Dorothy A Hanck; Harry A Fozzard
A structural motif for the voltage-gated potassium channel pore.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9215-9.
1995: P K Khera; G R Benzinger; Gregory M Lipkind; Chester L Drum; Dorothy A Hanck; K M Blumenthal
Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination.
Biochemistry 1995;34(27):8533-41.
1995: K Ono; H A Fozzard; Dorothy A Hanck
A direct effect of forskolin on sodium channel bursting.
Pflügers Archiv : European journal of physiology 1995;429(4):561-9.
1994: E Page; GE Goings; Judy Upshaw-Earley; Dorothy A Hanck
Endocytosis and uptake of lucifer yellow by cultured atrial myocytes and isolated intact atria from adult rats. Regulation and subcellular localization.
Circulation research 1994;75(2):335-46.
1994: Dorothy A Hanck; Jonathan C Makielski; Michael F Sheets
Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.
The Journal of general physiology 1994;103(1):19-43.
1993: Michael F Sheets; Dorothy A Hanck
Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells.
Journal of cardiovascular electrophysiology 1993;4(6):686-94.
1993: E Page; Judy Upshaw-Earley; GE Goings; Dorothy A Hanck
Fluid-phase endocytosis by in situ cardiac myocytes of rat atria.
The American journal of physiology 1993;265(4 Pt 1):C986-96.
1993: K Ono; Harry A Fozzard; Dorothy A Hanck
Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.
Circulation research 1993;72(4):807-15.
1992: Michael F Sheets; Dorothy A Hanck
Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.
The Journal of physiology 1992;454():299-320.
1992: Dorothy A Hanck; Michael F Sheets
Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells.
The Journal of physiology 1992;454():267-98.
1992: Dorothy A Hanck; Michael F Sheets
Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells.
The American journal of physiology 1992;262(4 Pt 2):H1197-207.
1992: N el-Sherif; Harry A Fozzard; Dorothy A Hanck
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII.
Circulation research 1992;70(2):285-301.
1991: E Page; Judy Upshaw-Earley; GE Goings; Dorothy A Hanck
Inhibition of atrial peptide secretion at different stages of the secretory process: Ca2+ dependence.
The American journal of physiology 1991;261(6 Pt 1):C1162-72.
1991: Michael F Sheets; Dorothy A Hanck
Atrionatriuretic peptide and calcium-conducting sodium channels.
Science (New York, N.Y.) 1991;252(5004):449-52.
1991: E Page; Judy Upshaw-Earley; GE Goings; Dorothy A Hanck
Effect of external Ca2+ concentration on stretch-augmented natriuretic peptide secretion by rat atria.
The American journal of physiology 1991;260(4 Pt 1):C756-62.
1991: Jonathan C Makielski; L A Alpert; Dorothy A Hanck
Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells.
Journal of molecular and cellular cardiology 1991;23 Suppl 1():95-102.
1990: Dorothy A Hanck; Michael F Sheets; Harry A Fozzard
Gating currents associated with Na channels in canine cardiac Purkinje cells.
The Journal of general physiology 1990;95(3):439-57.
1990: B E Scanley; Dorothy A Hanck; T Chay; Harry A Fozzard
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.
The Journal of general physiology 1990;95(3):411-37.
1989: L A Alpert; Harry A Fozzard; Dorothy A Hanck; Jonathan C Makielski
Is there a second external lidocaine binding site on mammalian cardiac cells?
The American journal of physiology 1989;257(1 Pt 2):H79-84.
1988: Michael F Sheets; Dorothy A Hanck; Harry A Fozzard
Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells.
Circulation research 1988;63(2):386-98.
1988: Jonathan C Makielski; Albertas I Undrovinas; Dorothy A Hanck; Michael F Sheets; V V Nesterenko; L A Alpert; L V Rosenshtraukh; Harry A Fozzard
Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells.
Journal of molecular and cellular cardiology 1988;20(3):255-65.
1987: Harry A Fozzard; Dorothy A Hanck; Jonathan C Makielski; B E Scanley; Michael F Sheets
Sodium channels in cardiac Purkinje cells.
Experientia 1987;43(11-12):1162-8.
1987: Jonathan C Makielski; Michael F Sheets; Dorothy A Hanck; Craig T January; Harry A Fozzard
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.
Biophysical journal 1987;52(1):1-11.
1987: Michael F Sheets; B E Scanley; Dorothy A Hanck; Jonathan C Makielski; Harry A Fozzard
Open sodium channel properties of single canine cardiac Purkinje cells.
Biophysical journal 1987;52(1):13-22.
1986: Harry A Fozzard; I R Friedlander; Dorothy A Hanck; Craig T January; Jonathan C Makielski; Michael F Sheets
Sodium currents in single cardiac Purkinje cells.
Journal of the American College of Cardiology 1986;8(1 Suppl A):79A-85A.