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Wayne Hancock

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Waaga-Gasser Ana Maria; Grimm Martin R; Lutz Jens; Lange Volkmar; Lenhard Susanne M; Aviles Beatriz; Kist-van Holthe Joana E; Lebedeva Tatiana; Samsonov Dimitry; Meyer Detlef; Hancock Wayne W; Heemann Uwe; Gasser Martin; Chandraker Anil
Regulatory allospecific T cell clones abrogate chronic allograft rejection.
Gasser Martin; Waaga-Gasser Ana Maria; Grimm Michael W; Grimm Martin R; Lenhard Miriam S; Kist-van Holthe Joana E; Laskowski Igor; Shaw Gray D; Thiede Arnulf; Hancock Wayne W; Tilney Nicholas L
Selectin blockade plus therapy with low-dose sirolimus and cyclosporin a prevent brain death-induced renal allograft dysfunction.
Pratschke Johann; Paz Dustin; Wilhelm Markus J; Laskowski Igor; Kofla Gregorz; Vergopoulos Athanasios; MacKenzie Harald J; Tullius Stefan G; Neuhaus Peter; Hancock Wayne W; Volk Hans-Dieter; Tilney Nicholas L
Donor hypertension increases graft immunogenicity and intensifies chronic changes in long-surviving renal allografts.

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All Publications

2009: Waaga-Gasser Ana Maria; Grimm Martin R; Lutz Jens; Lange Volkmar; Lenhard Susanne M; Aviles Beatriz; Kist-van Holthe Joana E; Lebedeva Tatiana; Samsonov Dimitry; Meyer Detlef; Hancock Wayne W; Heemann Uwe; Gasser Martin; Chandraker Anil
Regulatory allospecific T cell clones abrogate chronic allograft rejection.
Journal of the American Society of Nephrology : JASN 2009;20(4):820-30.
2005: Gasser Martin; Waaga-Gasser Ana Maria; Grimm Michael W; Grimm Martin R; Lenhard Miriam S; Kist-van Holthe Joana E; Laskowski Igor; Shaw Gray D; Thiede Arnulf; Hancock Wayne W; Tilney Nicholas L
Selectin blockade plus therapy with low-dose sirolimus and cyclosporin a prevent brain death-induced renal allograft dysfunction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(4 Pt 1):662-70.
2004: Pratschke Johann; Paz Dustin; Wilhelm Markus J; Laskowski Igor; Kofla Gregorz; Vergopoulos Athanasios; MacKenzie Harald J; Tullius Stefan G; Neuhaus Peter; Hancock Wayne W; Volk Hans-Dieter; Tilney Nicholas L
Donor hypertension increases graft immunogenicity and intensifies chronic changes in long-surviving renal allografts.
Transplantation 2004;77(1):43-8.
2004: Karni Arnon; Balashov Konstantin; Hancock Wayne W; Bharanidharan Padmanabhan; Abraham Michal; Khoury Samia J; Weiner Howard L
Cyclophosphamide modulates CD4+ T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8+ T cells in secondary progressive multiple sclerosis.
Journal of neuroimmunology 2004;146(1-2):189-98.
2003: Frenkel Dan; Huang Zhihong; Maron Ruth; Koldzic Djordje N; Hancock Wayne W; Moskowitz Michael A; Weiner Howard L
Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6549-55.
2003: Sayegh Mohamed H; Wu Zihao; Hancock Wayne W; Langmuir Peter B; Mata Marielena; Sandner Sigrid; Kishimoto Koji; Sho Masayuki; Palmer Ed; Mitchell Richard N; Turka Laurence A
Allograft rejection in a new allospecific CD4+ TCR transgenic mouse.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(4):381-9.
2002: Wilhelm M J; Pratschke J; Beato F; Taal M; Laskowski I A; Paz D M; Schmid C; Hancock W W; Scheld H H; Tilney N L
Activation of proinflammatory mediators in heart transplants from brain-dead donors: evidence from a model of chronic rat cardiac allograft rejection.
Transplantation proceedings 2002;34(6):2359-60.
2002: Kusaka Mamoru; Mackenzie Harald S; Ziai Farzard; Hancock Wayne W; Tilney Nicholas L
Recipient hypertension potentiates chronic functional and structural injury of rat renal allografts.
Transplantation 2002;74(3):307-14.
2002: Gasser Martin; Waaga Ana Maria; Kist-Van Holthe Joana E; Lenhard Susanne M; Laskowski Igor; Shaw Gray D; Hancock Wayne W; Tilney Nicholas L
Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand.
Journal of the American Society of Nephrology : JASN 2002;13(7):1937-45.
2002: Laskowski Igor A; Pratschke Johann; Wilhelm Marcus M; Gasser Martin; Paz Dustin; Hancock Wayne W; Tilney Nicholas L
Early and late injury to renal transplants from non-heart-beating donors.
Transplantation 2002;73(9):1468-73.
2002: Laskowski Igor A; Pratschke Johann; Wilhelm Markus J; Dong Victor M; Beato Francisca; Taal Maarten; Gasser Martin; Hancock Wayne W; Sayegh Mohamed H; Tilney Nicholas L
Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats.
Journal of the American Society of Nephrology : JASN 2002;13(2):519-27.
2001: Pratschke J; Wilhelm M J; Laskowski I; Kusaka M; Beato F; Tullius S G; Neuhaus P; Hancock W W; Tilney N L
Influence of donor brain death on chronic rejection of renal transplants in rats.
Journal of the American Society of Nephrology : JASN 2001;12(11):2474-81.
2001: Laskowski I A; Hancock W W; Pratchke J; Wilhelm M J; Tilney N L
Accelerated graft dysfunction in renal isografts from non-heart-beating donors.
Transplantation proceedings 2001;33(1-2):909-10.
2001: Kusaka M; Pratschke J; Wilhelm M J; Ziai F; Zandi-Nejad K; Mackenzie H S; Hancock W W; Tilney N L
Early and late inflammatory changes occurring in rat renal isografts from brain dead donors.
Transplantation proceedings 2001;33(1-2):867-8.
2001: Tilney N L; Paz D; Ames J; Gasser M; Laskowski I; Hancock W W
Ischemia-reperfusion injury.
Transplantation proceedings 2001;33(1-2):843-4.
2001: Pratschke J; Wilhelm M J; Laskowski I; Kusaka M; Paz D; Tullius S G; Neuhaus P; Hancock W W; Tilney N L
The influence of donor brain death on long-term function of renal allotransplants in rats.
Transplantation proceedings 2001;33(1-2):693-4.
2001: Laskowski I A; Pratschke J; Wilhelm M J; Paz D; Ames J B; Dong V M; Beato F; Sayegh M H; Hancock W W; Tilney N L
Prolongation of survival and preservation of allograft structure and function by a signaling CD28 mAB in a rat model of chronic kidney rejection.
Transplantation proceedings 2001;33(1-2):567-8.
2001: Wilhelm M J; Pratschke J; Laskowski I A; Paz D M; Hancock W W; Tilney N L
Altered alloimmune response toward grafts from brain-dead donors in chronic rat cardiac allograft rejection.
Transplantation proceedings 2001;33(1-2):366-7.
2001: Wilhelm M J; Pratschke J; Paz D M; Laskowski I A; Mackenzie H S; Hancock W W; Tilney N L
Donor hypertension and recipient immune responsiveness in chronic rat cardiac allograft rejection.
Transplantation proceedings 2001;33(1-2):321-2.
2000: Wilhelm M J; Pratschke J; Beato F; Taal M; Kusaka M; Hancock W W; Tilney N L
Activation of the heart by donor brain death accelerates acute rejection after transplantation.
Circulation 2000;102(19):2426-33.
2000: Luo Y; Fischer F R; Hancock W W; Dorf M E
Macrophage inflammatory protein-2 and KC induce chemokine production by mouse astrocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):4015-23.
2000: Fischer F R; Santambrogio L; Luo Y; Berman M A; Hancock W W; Dorf M E
Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression.
Journal of neuroimmunology 2000;110(1-2):195-208.
2000: Pratschke J; Wilhelm M J; Kusaka M; Beato F; Milford E L; Hancock W W; Tilney N L
Accelerated rejection of renal allografts from brain-dead donors.
Annals of surgery 2000;232(2):263-71.
2000: Kusaka M; Pratschke J; Wilhelm M J; Ziai F; Zandi-Nejad K; Mackenzie H S; Hancock W W; Tilney N L
Activation of inflammatory mediators in rat renal isografts by donor brain death.
Transplantation 2000;69(3):405-10.
1999: Maron R; Hancock W W; Slavin A; Hattori M; Kuchroo V; Weiner H L
Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines.
International immunology 1999;11(9):1573-80.
1999: Balashov K E; Rottman J B; Weiner H L; Hancock W W
CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6873-8.
1999: Knoflach A; Magee C; Denton M D; Kim K S; Buelow R; Hancock W W; Sayegh M H
Immunomodulatory functions of hyaluronate in the LEW-to-F344 model of chronic cardiac allograft rejection.
Transplantation 1999;67(6):909-14.
1999: Wilhelm M J; Pratschke J; Kusaka M; Hancock W W; Tilney N L
Donor brain death affects tempo and intensity of acute rejection of rat chronic allografts.
Transplantation proceedings 1999;31(1-2):1008-9.
1999: Pratschke J; Wilhelm M J; Kusaka M; Hancock W W; Tilney N L
Activation of proinflammatory genes in somatic organs as a consequence of brain death.
Transplantation proceedings 1999;31(1-2):1003-5.
1999: Pratschke J; Wilhelm M J; Kusaka M; Hancock W W; Tilney N L
Acute rejection of rat renal allografts is accelerated by donor brain death.
Transplantation proceedings 1999;31(1-2):874-5.
1999: Kusaka M; Ziai F; Hancock W W; Tilney N L; Mackenzie H S
Systemic hypertension accelerates chronic rejection of renal allografts in the rat.
Transplantation proceedings 1999;31(1-2):869.
1999: Pratschke J; Wilhelm M J; Kusaka M; Basker M; Cooper D K; Hancock W W; Tilney N L
Brain death and its influence on donor organ quality and outcome after transplantation.
Transplantation 1999;67(3):343-8.
1998: Hancock W W; Buelow R; Sayegh M H; Turka L A
Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes.
Nature medicine 1998;4(12):1392-6.
1998: Miyatake T; Koyamada N; Hancock W W; Soares M P; Bach F H
Survival of accommodated cardiac xenografts upon retransplantation into cyclosporine-treated recipients.
Transplantation 1998;65(12):1563-9.
1998: Takada M; Nadeau K C; Hancock W W; Mackenzie H S; Shaw G D; Waaga A M; Chandraker A; Sayegh M H; Tilney N L
Effects of explosive brain death on cytokine activation of peripheral organs in the rat.
Transplantation 1998;65(12):1533-42.
1998: Hancock W W
Basic science aspects of chronic rejection: induction of protective genes to prevent development of transplant arteriosclerosis.
Transplantation proceedings 1998;30(4):1585-9.
1998: Coito A J; Korom S; Hancock W W; Kupiec-Weglinski J W
Blockade of alpha 4 beta 1-integrin-fibronectin adhesive interactions prevents chronic allograft rejection in sensitized recipients.
Transplantation proceedings 1998;30(4):939-40.
1998: Chandraker A; Azuma H; Nadeau K; Carpenter C B; Tilney N L; Hancock W W; Sayegh M H
Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection.
The Journal of clinical investigation 1998;101(11):2309-18.
1998: Koyamada N; Miyatake T; Candinas D; Mark W; Hechenleitner P; Hancock W W; Soares M P; Bach F H
Transient complement inhibition plus T-cell immunosuppression induces long-term survival of mouse-to-rat cardiac xenografts.
Transplantation 1998;65(9):1210-5.
1998: Miyatake T; Sato K; Takigami K; Koyamada N; Hancock W W; Bazin H; Latinne D; Bach F H; Soares M P
Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):4114-23.
1998: Korom S; Hancock W W; Coito A J; Kupiec-Weglinski J W
Blockade of very late antigen-4 integrin binding to fibronectin in allograft recipients. II. Treatment with connecting segment-1 peptides prevents chronic rejection by attenuating arteriosclerotic development and suppressing intragraft T cell and macrophage activation.
Transplantation 1998;65(6):854-9.
1998: Salom R N; Maguire J A; Hancock W W
Endothelial activation and cytokine expression in human acute cardiac allograft rejection.
Pathology 1998;30(1):24-9.
1997: Hancock W W
Impact of alloimmunity on chronic tissue remodelling: role of cytokines and protective genes in the vessel wall.
Transplant immunology 1997;5(4):277-81.
1997: Sayegh M H; Zheng X G; Magee C; Hancock W W; Turka L A
Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients.
Transplantation 1997;64(12):1646-50.
1997: Hancock W W; Miyatake T; Koyamada N; Kut J P; Soares M; Russell M E; Bach F H; Sayegh M H
Effects of leflunomide and deoxyspergualin in the guinea pig-->rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin.
Transplantation 1997;64(5):696-704.
1997: Bach F H; Ferran C; Soares M; Wrighton C J; Anrather J; Winkler H; Robson S C; Hancock W W
Modification of vascular responses in xenotransplantation: inflammation and apoptosis.
Nature medicine 1997;3(9):944-8.
1997: Murphy B; Kim K S; Buelow R; Sayegh M H; Hancock W W
Synthetic MHC class I peptide prolongs cardiac survival and attenuates transplant arteriosclerosis in the Lewis-->Fischer 344 model of chronic allograft rejection.
Transplantation 1997;64(1):14-9.
1997: Kopp C W; Siegel J B; Hancock W W; Anrather J; Winkler H; Geczy C L; Kaczmarek E; Bach F H; Robson S C
Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors.
Transplantation 1997;63(5):749-58.
1997: Hancock W W
Beyond hyperacute rejection: strategies for development of pig-->primate xenotransplantation.
Kidney international. Supplement 1997;58():S36-40.
1997: Onodera K; Hancock W W; Graser E; Volk H D; Lehmann M; Chandraker A; Sayegh M H; Kupiec-Weglinski J W
Th2-type cytokines in the "infectious" tolerance pathway.
Transplantation proceedings 1997;29(1-2):1290-1.
1997: Mark W; Hechenleitner P; Sayegh M H; Hancock W W; Candinas D
Importance of the CD28/B7 costimulatory pathway in the development of chronic ductopenic rejection in a new model of orthotopic rat liver allotransplantation.
Transplantation proceedings 1997;29(1-2):1029.
1997: Bach F H; Ferran C; Candinas D; Miyatake T; Koyamada N; Mark W; Hechenleitner P; Hancock W W
Accommodation of xenografts: expression of "protective genes" in endothelial and smooth muscle cells.
Transplantation proceedings 1997;29(1-2):56-8.
1997: Wasowska B; Hancock W W; Onodera K; Korom S; Stadlbauer T H; Zheng X X; Strom T B; Kupiec-Weglinski J W
Rapamycin and cyclosporine A treatment: a novel regimen to prevent chronic allograft rejection in sensitized hosts.
Transplantation proceedings 1997;29(1-2):333.
1997: Onodera K; Hancock W W; Graser E; Lehmann M; Sayegh M H; Strom T B; Volk H D; Kupiec-Weglinski J W
Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1572-81.
1997: Bach F H; Ferran C; Hechenleitner P; Mark W; Koyamada N; Miyatake T; Winkler H; Badrichani A; Candinas D; Hancock W W
Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment.
Nature medicine 1997;3(2):196-204.
1997: Robson S C; Kaczmarek E; Siegel J B; Candinas D; Koziak K; Millan M; Hancock W W; Bach F H
Loss of ATP diphosphohydrolase activity with endothelial cell activation.
The Journal of experimental medicine 1997;185(1):153-63.
1996: Akalin E; Chandraker A; Russell M E; Turka L A; Hancock W W; Sayegh M H
CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo.
Transplantation 1996;62(12):1942-5.
1996: Candinas D; Belliveau S; Koyamada N; Miyatake T; Hechenleitner P; Mark W; Bach F H; Hancock W W
T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection.
Transplantation 1996;62(12):1920-7.
1996: Candinas D; Mark W; Kaever V; Miyatake T; Koyamada N; Hechenleitner P; Hancock W W
Immunomodulatory effects of the alkaloid sinomenine in the high responder ACI-to-Lewis cardiac allograft model.
Transplantation 1996;62(12):1855-60.
1996: Koyamada N; Miyatake T; Candinas D; Hechenleitner P; Siegel J; Hancock W W; Bach F H; Robson S C
Apyrase administration prolongs discordant xenograft survival.
Transplantation 1996;62(12):1739-43.
1996: Candinas D; Koyamada N; Miyatake T; Siegel J; Hancock W W; Bach F H; Robson S C
Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions.
Thrombosis and haemostasis 1996;76(5):807-12.
1996: Hancock W W; Sayegh M H; Zheng X G; Peach R; Linsley P S; Turka L A
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13967-72.
1996: Azuma H; Chandraker A; Nadeau K; Hancock W W; Carpenter C B; Tilney N L; Sayegh M H
Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12439-44.
1996: Khoury S J; Gallon L; Verburg R R; Chandraker A; Peach R; Linsley P S; Turka L A; Hancock W W; Sayegh M H
Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3700-5.
1996: Candinas D; Lesnikoski B A; Robson S C; Miyatake T; Scesney S M; Marsh H C; Ryan U S; Dalmasso A P; Hancock W W; Bach F H
Effect of repetitive high-dose treatment with soluble complement receptor type 1 and cobra venom factor on discordant xenograft survival.
Transplantation 1996;62(3):336-42.
1996: Candinas D; Lesnikoski B A; Hancock W W; Otsu I; Koyamada N; Dalmasso A P; Robson S C; Bach F H
Inhibition of platelet integrin GPIIbIIIa prolongs survival of discordant cardiac xenografts.
Transplantation 1996;62(1):1-5.
1996: Robson S C; Candinas D; Winkler H; Kopp C; Hancock W W; Bach F H
Immunobiology of discordant xenograft rejection and potential therapeutic modalities.
Transplantation proceedings 1996;28(3):1154-5.
1996: Lesnikoski B A; Candinas D; Hancock W W; Otsu I; Siegel J; Bach F H; Robson S C
Inhibition of platelet GPIIbIIIa prolongs survival of discordant cardiac xenografts.
Transplantation proceedings 1996;28(2):703.
1996: Candinas D; Bach F H; Hancock W W
Delayed xenograft rejection in complement-depleted T-cell-deficient rat recipients of guinea pig cardiac grafts.
Transplantation proceedings 1996;28(2):678.
1996: Candinas D; Lesnikoski B A; Robson S C; Scesney S M; Otsu I; Myiatake T; Marsh H C; Ryan U S; Hancock W W; Bach F H
Soluble complement receptor type 1 and cobra venom factor in discordant xenotransplantation.
Transplantation proceedings 1996;28(2):581.
1996: Robson S C; Candinas D; Siegel J B; Kopp C; Millan M; Hancock W W; Bach F H
Potential mechanism of abnormal thromboregulation in xenograft rejection: loss of ecto-ATPases upon endothelial cell activation.
Transplantation proceedings 1996;28(2):536.
1996: Robson S C; Young V K; Cook N S; Metternich R; Kasper-Konig W; Lesnikoski B A; Pierson R N; Hancock W W; Candinas D; White D J; Bach F H
Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection.
Transplantation 1996;61(6):862-8.
1996: Binder J; Lehmann M; Graser E; Hancock W W; Watschinger B; Onodera K; Sayegh M H; Volk H D; Kupiec-Weglinski J W
The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts.
Transplantation 1996;61(5):804-11.
1996: Russell M E; Hancock W W; Akalin E; Wallace A F; Glysing-Jensen T; Willett T A; Sayegh M H
Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.
The Journal of clinical investigation 1996;97(3):833-8.
1996: Wasowska B; Wieder K J; Hancock W W; Zheng X X; Berse B; Binder J; Strom T B; Kupiec-Weglinski J W
Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with rapamycin.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(1):395-404.
1995: Hancock W W; Grey S T; Hau L; Akalin E; Orthner C; Sayegh M H; Salem H H
Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses.
Transplantation 1995;60(12):1525-32.
1995: Binder J; Graser E; Hancock W W; Wasowska B; Sayegh M H; Volk H D; Kupiec-Weglinski J W
Downregulation of intragraft IFN-gamma expression correlates with increased IgG1 alloantibody response following intrathymic immunomodulation of sensitized rat recipients.
Transplantation 1995;60(12):1516-24.
1995: Khoury S J; Akalin E; Chandraker A; Turka L A; Linsley P S; Sayegh M H; Hancock W W
CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4521-4.
1995: Hancock W W; Polanski M; Zhang J; Blogg N; Weiner H L
Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.
The American journal of pathology 1995;147(5):1193-9.
1995: Bach F H; Robson S C; Winkler H; Ferran C; Stuhlmeier K M; Wrighton C J; Hancock W W
Barriers to xenotransplantation.
Nature medicine 1995;1(9):869-73.
1995: Khoury S J; Gallon L; Chen W; Betres K; Russell M E; Hancock W W; Carpenter C B; Sayegh M H; Weiner H L
Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo.
The Journal of experimental medicine 1995;182(2):357-66.
1995: Russell M E; Hancock W W; Wallace A F; Wyner L R; Karnovsky M J
Modulation of inflammatory activation pathways in the Lewis-to-F-344 rat chronic cardiac rejection model.
Transplantation proceedings 1995;27(3):2100-4.
1995: Watschinger B; Sayegh M H; Hancock W W; Russell M E
Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis.
The American journal of pathology 1995;146(5):1065-72.
1995: Sayegh M H; Akalin E; Hancock W W; Russell M E; Carpenter C B; Linsley P S; Turka L A
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.
The Journal of experimental medicine 1995;181(5):1869-74.
1995: Robson S C; Candinas D; Hancock W W; Wrighton C; Winkler H; Bach F H
Role of endothelial cells in transplantation.
International archives of allergy and immunology 1995;106(4):305-22.
1995: Bach F H; Robson S C; Ferran C; Millan M; Anrather J; Kopp C; Lesnikoski B; Goodman D J; Hancock W W; Wrighton C
Xenotransplantation: endothelial cell activation and beyond.
Transplantation proceedings 1995;27(1):77-9.
1995: Tullius S G; Heemann U W; Azuma H; Hancock W W; Pradham P; Tilney N L
Antigen-independent events mimic characteristic changes of chronic allograft rejection.
Transplantation proceedings 1995;27(1):561-3.
1995: Schmidbauer G; Hancock W W; Wasowska B; Binder J; Padberg W; Kupiec-Weglinski J W
Rapamycin abrogates accelerated rejection in sensitized rats by selectively suppressing intragraft cell activation, adhesion/binding properties, and modulating serum alloantibody responses.
Transplantation proceedings 1995;27(1):427-9.
1995: Wasowska B; Wieder K J; Hancock W W; Berse B; Binder J; Strom T B; Kupiec-Weglinski J W
Cytokine and alloantibody networks in long-term cardiac allografts in rapamycin-treated sensitized rat recipients.
Transplantation proceedings 1995;27(1):423-6.
1995: Lesnikoski B A; Shaffer D A; Van der Werf W J; Dalmasso A P; Soares M P; Latinne D; Bazin H; Hancock W W; Bach F H
Endothelial and host mononuclear cell activation and cytokine expression during rejection of pig-to-baboon discordant xenografts.
Transplantation proceedings 1995;27(1):290-1.
1995: Binder J; Hancock W W; Watschinger B; Wasowska B; Sayegh M H; Kupiec-Weglinski J W
Abrogation of accelerated allograft rejection by intrathymic injection of donor spleen cells is associated with upregulation of donor-reactive IgM, IgG1, and IgG2A, but depression of IgG2B in the circulation and at the graft site.
Transplantation proceedings 1995;27(1):138-41.
1995: Binder J; Hancock W W; Wasowska B; Gallon L; Watschinger B; Sayegh M H; Brock J; Lehmann M; Volk H D; Kupiec-Weglinski J W
Donor-specific transplantation unresponsiveness in sensitized rats following treatment with a nondepleting anti-CD4 MAb is associated with selective intragraft sparing of Th2-like cells.
Transplantation proceedings 1995;27(1):114-6.
1995: Binder J; Hancock W W; Watschinger B; Wasowska B; Sayegh M H; Kupiec-Weglinski J W
The alloantibody network following intrathymic immunomodulation of sensitized rat recipients of cardiac allografts.
Transplantation 1995;59(4):590-7.
1995: Russell M E; Wallace A F; Hancock W W; Sayegh M H; Adams D H; Sibinga N E; Wyner L R; Karnovsky M J
Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection.
Transplantation 1995;59(4):572-8.
1995: Akalin E; Hancock W W; Perico N; Remuzzi G; Imberti O; Carpenter C B; Sayegh M H
Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.
Journal of the American Society of Nephrology : JASN 1995;5(7):1418-25.
1994: Millan M T; Ferran C; Winkler H; Blakely M L; van der Werf W J; Hancock W W; Bach F H
Xenotransplantation: problems and approaches.
Transplantation proceedings 1994;26(6):3593-6.
1994: Hancock W W; Adams D H; Wyner L R; Sayegh M H; Karnovsky M J
CD4+ mononuclear cells induce cytokine expression, vascular smooth muscle cell proliferation, and arterial occlusion after endothelial injury.
The American journal of pathology 1994;145(5):1008-14.
1994: Blakely M L; Van der Werf W J; Berndt M C; Dalmasso A P; Bach F H; Hancock W W
Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection.
Transplantation 1994;58(10):1059-66.
1994: Tullius S G; Heemann U; Hancock W W; Azuma H; Tilney N L
Long-term kidney isografts develop functional and morphologic changes that mimic those of chronic allograft rejection.
Annals of surgery 1994;220(4):425-32; discussion 432-5.
1994: Salom R N; Maguire J A; Esmore D; Hancock W W
Analysis of proliferating cell nuclear antigen expression aids histological diagnosis and is predictive of progression of human cardiac allograft rejection.
The American journal of pathology 1994;145(4):876-82.
1994: Grey S T; Tsuchida A; Hau H; Orthner C L; Salem H H; Hancock W W
Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3664-72.
1994: Sayegh M H; Perico N; Gallon L; Imberti O; Hancock W W; Remuzzi G; Carpenter C B
Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy.
Transplantation 1994;58(2):125-32.
1994: Tullius S G; Hancock W W; Heemann U; Azuma H; Tilney N L
Reversibility of chronic renal allograft rejection. Critical effect of time after transplantation suggests both host immune dependent and independent phases of progressive injury.
Transplantation 1994;58(1):93-9.
1994: Binder J; Sayegh M H; Watschinger B; Hancock W W; Kupiec-Weglinski J W
Intrathymic injection of donor-specific X-irradiation-sensitive spleen cells abrogates accelerated rejection of cardiac allografts in sensitized rats.
Transplantation 1994;58(1):80-6.
1994: Hancock W W; Khoury S J; Carpenter C B; Sayegh M H
Differential effects of oral versus intrathymic administration of polymorphic major histocompatibility complex class II peptides on mononuclear and endothelial cell activation and cytokine expression during a delayed-type hypersensitivity response.
The American journal of pathology 1994;144(6):1149-58.
1994: Hofer E; Stuhlmeier K M; Blakely M L; Van der Werf W; Hancock W W; Hunt B J; Bach F H
Pathways of procoagulation in discordant xenografting.
Transplantation proceedings 1994;26(3):1322.
1994: Bach F H; Stuhlmeier K M; Vanhove B; Van der Werf W J; Blakely M L; de Martin R; Hancock W W; Winkler H
Endothelial cells in xenotransplantation: do they accommodate?
Transplantation proceedings 1994;26(3):1167-9.
1994: Schmidbauer G; Hancock W W; Wasowska B; Badger A M; Kupiec-Weglinski J W
Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion.
Transplantation 1994;57(6):933-41.
1994: Tullius S G; Heemann U W; Azuma H; Hancock W W; Tilney N L
Alloantigen-independent factors lead to signs of chronic rejection in long-term kidney isografts.
Transplant international : official journal of the European Society for Organ Transplantation 1994;7 Suppl 1():S306-7.
1993: Salom R N; Maguire J A; Hancock W W
Mechanism of a clinically relevant protocol to induce tolerance of cardiac allografts. Perioperative donor spleen cells plus cyclosporine suppress IL-2 and interferon-gamma production.
Transplantation 1993;56(6):1309-14.
1993: Kupiec-Weglinski J W; Wasowska B; Papp I; Schmidbauer G; Sayegh M H; Baldwin W M; Wieder K J; Hancock W W
CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):5053-61.
1993: Whitley W D; Hancock W W; Kupiec-Weglinski J W; DeSousa M; Tilney N L
Iron chelation suppresses mononuclear cell activation, modifies lymphocyte migration patterns, and prolongs rat cardiac allograft survival in rats.
Transplantation 1993;56(5):1182-8.
1993: Hancock W W; Blakely M L; Van der Werf W; Bach F H
Rejection of guinea pig cardiac xenografts post-cobra venom factor therapy is associated with infiltration by mononuclear cells secreting interferon-gamma and diffuse endothelial activation.
Transplantation proceedings 1993;25(5):2932.
1993: Salom R N; Maguire J A; Esmore D; Hancock W W
Proliferating cell nuclear antigen expression in endomyocardial biopsies is predictive of progression of rejection and the need for enhanced immunosuppression.
Transplantation proceedings 1993;25(5):2894-5.
1993: Coughlan A F; Berndt M C; Dunlop L C; Hancock W W
In vivo studies of P-selectin and platelet activating factor during endotoxemia, accelerated allograft rejection, and discordant xenograft rejection.
Transplantation proceedings 1993;25(5):2930-1.
1993: Grey S; Hau H; Salem H H; Hancock W W
Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-gamma, or PMA: modulation of effects on CD11b and CD14 but not CD25 or CD54 induction.
Transplantation proceedings 1993;25(5):2913-4.
1993: Sayegh M H; Perico N; Imberti O; Hancock W W; Carpenter C B; Remuzzi G
Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts.
Transplantation 1993;56(2):461-5.
1993: Khoury S J; Sayegh M H; Hancock W W; Gallon L; Carpenter C B; Weiner H L
Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide.
The Journal of experimental medicine 1993;178(2):559-66.
1993: Wieder K J; Hancock W W; Schmidbauer G; Corpier C L; Wieder I; Kobzik L; Strom T B; Kupiec-Weglinski J W
Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):1158-66.
1993: Schmidbauer G; Hancock W W; Badger A M; Kupiec-Weglinski J W
Induction of nonspecific x-irradiation-resistant suppressor cell activity in vivo and prolongation of vascularized allograft survival by SK&F 105685, a novel immunomodulatory azaspirane.
Transplantation 1993;55(6):1236-43.
1993: Hancock W W; Sayegh M H; Kwok C A; Weiner H L; Carpenter C B
Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation.
Transplantation 1993;55(5):1112-8.
1993: Tilney N L; Whitley W D; Tullius S G; Heemann U W; Wasowska B; Baldwin W M; Hancock W W
Serial analysis of cytokines, adhesion molecule expression, and humoral responses during development of chronic kidney allograft rejection in a new rat model.
Transplantation proceedings 1993;25(1 Pt 2):861-2.
1993: Schmidbauer G; Hancock W W; Wasowska B A; Sablinski T; Kupiec-Weglinski J W
Rapamycin treatment prevents and/or erases sensitization and abrogates accelerated rejection of vascularized organ allografts.
Transplantation proceedings 1993;25(1 Pt 1):712-3.
1993: Sablinski T; Hancock W W; Wasowska B A; Schmidbauer G; Baldwin W M; Kut J P; Milford E L; Kupiec-Weglinski J W
Modulation of acute and hyperacute rejection of xenografts in concordant hamster-to-rat combination.
Transplantation proceedings 1993;25(1 Pt 1):432-4.
1993: Sayegh M H; Khoury S J; Hancock W W; Weiner H L; Carpenter C B
Induction of immunity and oral tolerance to alloantigen by polymorphic class II major histocompatibility complex allopeptides in the rat.
Transplantation proceedings 1993;25(1 Pt 1):357-8.
1993: Schmidbauer G; Hancock W W; Badger A M; Kupiec-Weglinski J W
SK&F 105685 treatment induces suppressor cell activity and modulates cell adhesion properties in rat recipients of cardiac allografts.
Transplantation proceedings 1993;25(1 Pt 1):758-60.
1992: Khoury S J; Hancock W W; Weiner H L
Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.
The Journal of experimental medicine 1992;176(5):1355-64.
1992: Hancock W W; Whitley W D; Baldwin W M; Tilney N L
Cells, cytokines, adhesion molecules, and humoral responses in a rat model of chronic renal allograft rejection.
Transplantation proceedings 1992;24(5):2315-6.
1992: Hancock W W; Sayegh M H; Carpenter C B
In vivo evidence for the Th1/Th2 paradigm: oral alloantigen-induced modulation of accelerated allograft rejection is associated with dense intragraft IL-4.
Transplantation proceedings 1992;24(5):2313-4.
1992: Salom R N; Maguire J A; Hancock W W
Mechanism of a clinically relevant protocol to induce tolerance: peritransplant spleen cells plus cyclosporine suppress IL-2 and IFN-gamma production.
Transplantation proceedings 1992;24(5):2307-8.
1992: Hancock W W; Tsuchida A; Hau H; Thomson N M; Salem H H
The anticoagulants protein C and protein S display potent antiinflammatory and immunosuppressive effects relevant to transplant biology and therapy.
Transplantation proceedings 1992;24(5):2302-3.
1992: Sayegh M H; Khoury S J; Hancock W W; Weiner H L; Carpenter C B
Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7762-6.
1992: Hancock W W; Sayegh M H; Sablinski T; Kut J P; Kupiec-Weglinski J W; Milford E L
Blocking of mononuclear cell accumulation, cytokine production, and endothelial activation within rat cardiac allografts by CD4 monoclonal antibody therapy.
Transplantation 1992;53(6):1276-80.
1992: Sablinski T; Hancock W W; Schmidbauer G; Milford E L; Kupiec-Weglinski J W
CD4 MAb therapy diminishes sensitization to xenoantigen and abrogates hyperacute rejection of hamster cardiac grafts in rats.
Transplantation proceedings 1992;24(2):528-30.
1992: Hancock W W; Sayegh M H; Zhang Z J; Kwok C A; Weiner H L; Carpenter C B
Oral immunization with allogeneic splenocytes inhibits development of accelerated but not acute rejection of cardiac grafts: analysis of intragraft effector mechanisms.
Transplantation proceedings 1992;24(1):250-1.
1992: Hancock W W; Schmidbauer G; Badger A M; Kupiec-Weglinski J W
SK&F 105685 suppresses allogeneically induced mononuclear and endothelial cell activation and cytokine production and prolongs rat cardiac allograft survival.
Transplantation proceedings 1992;24(1):231-2.
1992: Hancock W W; Whitley D; Kupiec-Weglinski J W; Tilney N L
Oral iron chelator desferrithiocin blocks allogeneic mononuclear cell activation and cytokine production in vivo and prolongs rat cardiac allograft survival.
Transplantation proceedings 1992;24(1):214-5.
1992: Tsuchida A; Salem H; Thomson N; Hancock W W
Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression.
The Journal of experimental medicine 1992;175(1):81-90.
1991: Sablinski T; Hancock W W; Tilney N L; Kupiec-Weglinski J W
CD4 monoclonal antibodies in organ transplantation--a review of progress.
Transplantation 1991;52(4):579-89.
1991: Kupiec-Weglinski J W; Sablinski T; Hancock W W; Mix C T; Tilney N L
Synergistic interactions between anti-interleukin-2 receptor (IL-2R) MAb and CyA in sensitized rat recipients of cardiac allografts.
Transplantation proceedings 1991;23(1 Pt 1):285-6.
1991: Sablinski T; Sayegh M H; Kut J P; Hancock W W; Milford E L; Tilney N L; Kupiec-Weglinski J W
Therapeutic strategies targeted at CD4+ cells obviate accelerated rejection of cardiac allografts in sensitized rats.
Transplantation proceedings 1991;23(1 Pt 1):268-9.
1991: Kupiec-Weglinski J W; Sablinski T; Hancock W W; Di Stefano R; Mariani G; Mix C T; Tilney N L
Modulation of accelerated rejection of cardiac allografts in sensitized rats by anti-interleukin 2 receptor monoclonal antibody and cyclosporine therapy.
Transplantation 1991;51(2):300-5.
1991: Sablinski T; Sayegh M H; Hancock W W; Kut J P; Kwok C A; Milford E L; Tilney N L; Kupiec-Weglinski J W
Differential role of CD4+ cells in the sensitization and effector phases of accelerated graft rejection.
Transplantation 1991;51(1):226-31.
1990: Ueda H; Hancock W W; Cheung Y C; Diamantstein T; Tilney N L; Kupiec-Weglinski J W
The mechanism of synergistic interaction between anti-interleukin 2 receptor monoclonal antibody and cyclosporine therapy in rat recipients of organ allografts.
Transplantation 1990;50(4):545-50.
1990: Tanaka K; Tilney N L; Stunkel K G; Hancock W W; Diamantstein T; Kupiec-Weglinski J W
Pretreatment with cyclosporine and anti-interleukin 2 receptor antibody abrogates the anti-idiotype response in rat recipients of cardiac allografts.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7375-9.
1990: Ueda H; Hancock W W; Cheung Y C; Tanaka K; Kupiec-Weglinski J W; Tilney N L
Differential effects of interleukin 2 receptor-targeted therapy on heart and kidney allografts in rats. Depression of effectiveness of ART-18 monoclonal antibody treatment by uremia.
Transplantation 1990;49(6):1124-9.
1989: Tanaka K; Hancock W W; Osawa H; Stunkel K G; Alberghini T V; Diamantstein T; Tilney N L; Kupiec-Weglinski J W
Mechanism of action of anti-IL-2R monoclonal antibodies. ART-18 prolongs cardiac allograft survival in rats by elimination of IL-2R+ mononuclear cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2873-9.
1989: DiStefano R; Uhteg L C; Hancock W W; Araneda D; Kupiec-Weglinski J W; Tilney N L
Host-graft relationship in accelerated rejection of rat cardiac allografts.
Transplantation proceedings 1989;21(1 Pt 1):496-7.
1989: Lord R H; Padberg W M; Hancock W W; Kupiec-Weglinski J W; Tilney N L
Correlation of macrophage and NK cell numbers with "activation markers" in rat cardiac allografts.
Transplantation proceedings 1989;21(1 Pt 1):449-50.
1988: Lord R H; Padberg W M; Di Stefano R; Hancock W W; Araneda D; Rickles F R; Tilney N L; Kupiec-Weglinski J W
Immunohistologic profile of cells infiltrating acutely rejecting and long-surviving rat cardiac allografts.
Transplantation proceedings 1988;20(2):229-30.
1987: Lord R H; Hancock W W; Colby A J; Padberg W; Diamantstein T; Kupiec-Weglinski J W; Tilney N L
Effects of anti-IL 2 receptor monoclonal antibody and cyclosporine on IL 2 receptor-positive cells infiltrating cardiac allografts in the rat.
Transplantation proceedings 1987;19(1 Pt 1):354-5.
1987: Hancock W W; Lord R H; Colby A J; Diamantstein T; Rickles F R; Dijkstra C; Hogg N; Tilney N L
Identification of IL 2R+ T cells and macrophages within rejecting rat cardiac allografts, and comparison of the effects of treatment with anti-IL 2R monoclonal antibody or cyclosporin.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(1):164-70.

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