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Hiroshi Handa

Research Profile

Chemicals & Drugs

Physiology

Transcription, Genetic

Anatomy

Co-author Network

Publications

TOP 3
Kentaro Hotta; Yosuke Iizumi; Takeshi Imai; Takumi Ito; Yasuaki Kabe; Ryusuke Nabeshima; Akihiro Nashimoto; Akira Okada; Satoshi Sakamoto; Kumiko Sakata-Sogawa; Daisuke Shima; Masafumi Suzuki; Makio Tokunaga; Hajime Watanabe; Yuki Yamaguchi; Eiji Yasumura; Shinichi Aizawa; Hideki Ando; Motoki Azuma; Masaki Hiramoto; Hiroshi Handa
Vesnarinone Suppresses TNFα mRNA Expression by Inhibiting Valosin-Containing Protein.
Satoki Karasawa; Takeshi Kasama; Keisuke Miyazawa; Satoshi Sakamoto; Yuki Yamaguchi; Motoki Azuma; Takeshi Imai; Yasuaki Kabe; Hiroshi Handa
Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.
Yuki Yamaguchi; Hirotaka Shibata; Hiroshi Handa
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond.

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All Publications

2013: Kentaro Hotta; Yosuke Iizumi; Takeshi Imai; Takumi Ito; Yasuaki Kabe; Ryusuke Nabeshima; Akihiro Nashimoto; Akira Okada; Satoshi Sakamoto; Kumiko Sakata-Sogawa; Daisuke Shima; Masafumi Suzuki; Makio Tokunaga; Hajime Watanabe; Yuki Yamaguchi; Eiji Yasumura; Shinichi Aizawa; Hideki Ando; Motoki Azuma; Masaki Hiramoto; Hiroshi Handa
Vesnarinone Suppresses TNFα mRNA Expression by Inhibiting Valosin-Containing Protein.
Molecular pharmacology 2013;83(5):930-8.
2013: Satoki Karasawa; Takeshi Kasama; Keisuke Miyazawa; Satoshi Sakamoto; Yuki Yamaguchi; Motoki Azuma; Takeshi Imai; Yasuaki Kabe; Hiroshi Handa
Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.
Molecular pharmacology 2013;83(3):613-20.
2013: Yuki Yamaguchi; Hirotaka Shibata; Hiroshi Handa
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond.
Biochimica et biophysica acta 2013;1829(1):98-104.
2012: Satoshi Sakamoto; Mamoru Hatakeyama; Takumi Ito; Hiroshi Handa
Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound.
Bioorganic & medicinal chemistry 2012;20(6):1990-2001.
2012: Takumi Ito; Hiroshi Handa
Deciphering the mystery of thalidomide teratogenicity.
Congenital anomalies 2012;52(1):1-7.
2012: Yuki Ito; Satoki Karasawa; Yoshihisa Matsumoto; Tsuneyo Mimori; Akihiro Nashimoto; Satoshi Sakamoto; Yuki Yamaguchi; Teruya Enomoto; Yasuyoshi Hase; Takumi Ito; Hiroshi Handa
Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.
PloS one 2012;7(12):e50481.
2011: Teruya Enomoto; Masa-Aki Kawano; Iwao Kukimoto; Yuki Yamaguchi; Arnold J Berk; Hiroshi Handa
In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer.
Virology 2011;420(1):1-9.
2011: Yuichi Kitai; Takahiro Suzuki; Satoshi Inouye; Yuki Asakawa; Teruya Enomoto; Hajime Fukuda; Hiroshi Handa
Cell selective targeting of a simian virus 40 virus-like particle conjugated to epidermal growth factor.
Journal of biotechnology 2011;155(2):251-6.
2011: Ayumi Kawano; Shuhei Noguchi; Hiroshi Handa; Yohei Hayashi; Masami Horikoshi; Yuki Yamaguchi
Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(5):590-607.
2011: Takumi Ito; Hideki Ando; Hiroshi Handa
Teratogenic effects of thalidomide: molecular mechanisms.
Cellular and molecular life sciences : CMLS 2011;68(9):1569-79.
2011: Takumi Ito; Hiroshi Handa
[Molecular mechanism of thalidomide teratogenicity].
Seikagaku. The Journal of Japanese Biochemical Society 2011;83(2):118-22.
2011: Takuya Taneda; Wenyan Zhu; Qingfu Cao; Hajime Watanabe; Yuki Yamaguchi; Hiroshi Handa; Tadashi Wada
Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(2):231-42.
2010: Adarsh Sandhu; Hiroshi Handa; Masanori Abe
Synthesis and applications of magnetic nanoparticles for biorecognition and point of care medical diagnostics.
Nanotechnology 2010;21(44):442001.
2010: Kunitoshi Chiba; Junichi Yamamoto; Yuki Yamaguchi; Hiroshi Handa
Promoter-proximal pausing and its release: molecular mechanisms and physiological functions.
Experimental cell research 2010;316(17):2723-30.
2010: Sol Kim; Junichi Yamamoto; Yexi Chen; Masatoshi Aida; Tadashi Wada; Hiroshi Handa; Yuki Yamaguchi
Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(9):1003-13.
2010: Kanako Kume; Yosuke Iizumi; Masashi Shimada; Yuki Ito; Tsutomu Kishi; Yuki Yamaguchi; Hiroshi Handa
Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(4):339-49.
2010: Takumi Ito; Hideki Ando; Takayuki Suzuki; Toshihiko Ogura; Kentaro Hotta; Yoshimasa Imamura; Yuki Yamaguchi; Hiroshi Handa
Identification of a primary target of thalidomide teratogenicity.
Science (New York, N.Y.) 2010;327(5971):1345-50.
2010: Sang Yoon Park; Hiroshi Handa; Adarsh Sandhu
Magneto-optical biosensing platform based on light scattering from self-assembled chains of functionalized rotating magnetic beads.
Nano letters 2010;10(2):446-51.
2010: Yuka Masaike; Takeshi Takagi; Masataka Hirota; Joe Yamada; Satoru Ishihara; Tetsu M C Yung; Takamasa Inoue; Chika Sawa; Hiroshi Sagara; Satoshi Sakamoto; Yasuaki Kabe; Yasuyuki Takahashi; Yuki Yamaguchi; Hiroshi Handa
Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates.
Molecular pharmacology 2010;77(2):262-9.
2009: Yexi Chen; Yuki Yamaguchi; Yuta Tsugeno; Junichi Yamamoto; Tomoko Yamada; Mitsuhiro Nakamura; Hisatake Koji; Hiroshi Handa
DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.
Genes & development 2009;23(23):2765-77.
2009: Tetsu M C Yung; Takashi Narita; Toshiharu Komori; Yuki Yamaguchi; Hiroshi Handa
Cellular dynamics of the negative transcription elongation factor NELF.
Experimental cell research 2009;315(10):1693-705.
2009: Chikanori Kuramori; Yasuyoshi Hase; Koichi Hoshikawa; Keiko Watanabe; Takeyuki Nishi; Takako Hishiki; Tomoyoshi Soga; Akihiro Nashimoto; Yasuaki Kabe; Yuki Yamaguchi; Hajime Watanabe; Kohsuke Kataoka; Makoto Suematsu; Hiroshi Handa
Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):143-51.
2009: Toshiharu Komori; Naoto Inukai; Tomoko Yamada; Yuki Yamaguchi; Hiroshi Handa
Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(3):343-54.
2009: Chikanori Kuramori; Motoki Azuma; Kanako Kume; Yuki Kaneko; Atsushi Inoue; Yuki Yamaguchi; Yasuaki Kabe; Takamitsu Hosoya; Masahiro Kizaki; Makoto Suematsu; Hiroshi Handa
Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus.
Biochemical and biophysical research communications 2009;379(2):519-25.
2009: Satoshi Sakamoto; Yasuaki Kabe; Mamoru Hatakeyama; Yuki Yamaguchi; Hiroshi Handa
Development and application of high-performance affinity beads: toward chemical biology and drug discovery.
Chemical record (New York, N.Y.) 2009;9(1):66-85.
2008: Kozue Ando; Satoshi Hirao; Yasuaki Kabe; Yuji Ogura; Iwao Sato; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity.
Nucleic acids research 2008;36(13):4327-36.
2008: Ryou-u Takahashi; Shin-nosuke Kanesashi; Takamasa Inoue; Teruya Enomoto; Masa-Aki Kawano; Hiroko Tsukamoto; Fumitaka Takeshita; Takeshi Imai; Takahiro Ochiya; Kohsuke Kataoka; Yuki Yamaguchi; Hiroshi Handa
Presentation of functional foreign peptides on the surface of SV40 virus-like particles.
Journal of biotechnology 2008;135(4):385-92.
2008: Kosuke Nishio; Yuka Masaike; Morihito Ikeda; Hiroki Narimatsu; Nobuyuki Gokon; Shingo Tsubouchi; Mamoru Hatakeyama; Satoshi Sakamoto; Naohiro Hanyu; Adarsh Sandhu; Haruma Kawaguchi; Masanori Abe; Hiroshi Handa
Development of novel magnetic nano-carriers for high-performance affinity purification.
Colloids and surfaces. B, Biointerfaces 2008;64(2):162-9.
2008: Masafumi Suzuki; Shoichiro Furukawa; Chikanori Kuramori; Chika Sawa; Yasuaki Kabe; Mitsuhiro Nakamura; Jun-Ichi Sawada; Yuki Yamaguchi; Satoshi Sakamoto; Satoshi Inouye; Hiroshi Handa
Development of a chemical screening system using aqueorin-fused protein.
Biochemical and biophysical research communications 2008;368(3):600-5.
2008: Takamasa Inoue; Masa-aki Kawano; Ryou-u Takahashi; Hiroko Tsukamoto; Teruya Enomoto; Takeshi Imai; Kohsuke Kataoka; Hiroshi Handa
Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with the minor capsid proteins VP2/3.
Journal of biotechnology 2008;134(1-2):181-92.
2008: Makoto Yoshida; Yasuaki Kabe; Tadashi Wada; Akira Asai; Hiroshi Handa
A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads.
Molecular pharmacology 2008;73(3):987-94.
2008: Yasuyoshi Hase; Michiko Tatsuno; Takeyuki Nishi; Kosuke Kataoka; Yasuaki Kabe; Yuki Yamaguchi; Nobuaki Ozawa; Michiya Natori; Hiroshi Handa; Hajime Watanabe
Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm.
Biochemical and biophysical research communications 2008;366(1):66-72.
2008: Motoki Azuma; Yasuaki Kabe; Chikanori Kuramori; Masao Kondo; Yuki Yamaguchi; Hiroshi Handa
Adenine nucleotide translocator transports haem precursors into mitochondria.
PloS one 2008;3(8):e3070.
2007: Yosuke Iizumi; Hiroshi Sagara; Yasuaki Kabe; Motoki Azuma; Kanako Kume; Michinaga Ogawa; Takeshi Nagai; Peter G Gillespie; Chihiro Sasakawa; Hiroshi Handa
The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function.
Cell host & microbe 2007;2(6):383-92.
2007: Hiroko Tsukamoto; Masa-Aki Kawano; Takamasa Inoue; Teruya Enomoto; Ryou-u Takahashi; Naoki Yokoyama; Noriaki Yamamoto; Takeshi Imai; Kohsuke Kataoka; Yuki Yamaguchi; Hiroshi Handa
Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(11):1267-79.
2007: Yuki Yamaguchi; Takashi Mura; Sittinan Chanarat; Sachiko Okamoto; Hiroshi Handa
Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(7):863-75.
2007: Takashi Narita; Tetsu M C Yung; Junichi Yamamoto; Yasunori Tsuboi; Hideyuki Tanabe; Kiyoji Tanaka; Yuki Yamaguchi; Hiroshi Handa
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
Molecular cell 2007;26(3):349-65.
2007: Kosuke Nishio; Nobuyuki Gokon; Makoto Hasegawa; Yuji Ogura; Morihito Ikeda; Hiroki Narimatsu; Masaru Tada; Yuki Yamaguchi; Satoshi Sakamoto; Masanori Abe; Hiroshi Handa
Identification of a chemical substructure that is immobilized to ferrite nanoparticles (FP).
Colloids and surfaces. B, Biointerfaces 2007;54(2):249-53.
2007: Naoki Yokoyama; Masa-aki Kawano; Hiroko Tsukamoto; Teruya Enomoto; Takamasa Inoue; Ryou-u Takahashi; Akira Nakanishi; Takeshi Imai; Tadashi Wada; Hiroshi Handa
Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1.
Journal of biochemistry 2007;141(2):279-86.
2007: Noriaki Yamamoto; Masato Suzuki; Masa-Aki Kawano; Takamasa Inoue; Ryou-u Takahashi; Hiroko Tsukamoto; Teruya Enomoto; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Adeno-associated virus site-specific integration is regulated by TRP-185.
Journal of virology 2007;81(4):1990-2001.
2007: Masato Yugami; Yasuaki Kabe; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
hnRNP-U enhances the expression of specific genes by stabilizing mRNA.
FEBS letters 2007;581(1):1-7.
2007: Wenyan Zhu; Tadashi Wada; Sachiko Okabe; Takuya Taneda; Yuki Yamaguchi; Hiroshi Handa
DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation.
Nucleic acids research 2007;35(12):4064-75.
2006: Yasuaki Kabe; Masashi Ohmori; Kazuya Shinouchi; Yasunori Tsuboi; Satoshi Hirao; Motoki Azuma; Hajime Watanabe; Ichiro Okura; Hiroshi Handa
Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier.
The Journal of biological chemistry 2006;281(42):31729-35.
2006: Masatoshi Aida; Yexi Chen; Koichi Nakajima; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene.
Molecular and cellular biology 2006;26(16):6094-104.
2006: Nobuyuki Sakurai; Yasuhiro Miki; Takashi Suzuki; Keiko Watanabe; Takashi Narita; Kozue Ando; Tetsu M C Yung; Daisuke Aoki; Hironobu Sasano; Hiroshi Handa
Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12.
The Journal of steroid biochemistry and molecular biology 2006;99(4-5):174-81.
2006: Masa-aki Kawano; Takamasa Inoue; Hiroko Tsukamoto; Tatsuya Takaya; Teruya Enomoto; Ryou-u Takahashi; Naoki Yokoyama; Noriaki Yamamoto; Akira Nakanishi; Takeshi Imai; Tadashi Wada; Kohsuke Kataoka; Hiroshi Handa
The VP2/VP3 minor capsid protein of simian virus 40 promotes the in vitro assembly of the major capsid protein VP1 into particles.
The Journal of biological chemistry 2006;281(15):10164-73.
2006: Yuji Ogura; Motoki Azuma; Yasunori Tsuboi; Yasuaki Kabe; Yuki Yamaguchi; Tadashi Wada; Hajime Watanabe; Hiroshi Handa
TFII-I down-regulates a subset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor alpha.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(4):373-81.
2006: Hisakage Funabashi; Yasuhiro Tanaka; Yoshimasa Imamura; Masayasu Mie; Takashi Manabe; Hiroshi Tanaka; Takashi Takahashi; Hiroshi Handa; Masuo Aizawa; Eiry Kobatake
Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening.
Biosensors & bioelectronics 2006;21(9):1675-83.
2006: Tomoko Yamada; Yuki Yamaguchi; Naoto Inukai; Sachiko Okamoto; Takashi Mura; Hiroshi Handa
P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.
Molecular cell 2006;21(2):227-37.
2006: Makoto Hasegawa; Hiroshi Ohno; Hiroshi Tanaka; Mamoru Hatakeyama; Haruma Kawaguchi; Takashi Takahashi; Hiroshi Handa
Affinity identification of delta-opioid receptors using latex nanoparticles.
Bioorganic & medicinal chemistry letters 2006;16(1):158-61.
2005: Sophie Deléhouzée; Tatsufumi Yoshikawa; Chika Sawa; Jun-ichi Sawada; Takumi Ito; Masashi Omori; Tadashi Wada; Yuki Yamaguchi; Yasuaki Kabe; Hiroshi Handa
GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(7):717-31.
2005: Yoshihiro Ohtsu; Reiko Ohba; Yoshimasa Imamura; Motoo Kobayashi; Hidetaka Hatori; Tatsuya Zenkoh; Mamoru Hatakeyama; Takashi Manabe; Motohiro Hino; Yuki Yamaguchi; Kohsuke Kataoka; Haruma Kawaguchi; Hajime Watanabe; Hiroshi Handa
Selective ligand purification using high-performance affinity beads.
Analytical biochemistry 2005;338(2):245-52.
2005: Yasuaki Kabe; Kozue Ando; Satoshi Hirao; Makoto Yoshida; Hiroshi Handa
Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus.
Antioxidants & redox signaling 2005;7(3-4):395-403.
2005: Martin Parent; Tetsu M C Yung; Ann Rancourt; Erick L Y Ho; Stéphane Vispé; Fumihiko Suzuki-Matsuda; Aki Uehara; Tadashi Wada; Hiroshi Handa; Masahiko S Satoh
Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complex.
The Journal of biological chemistry 2005;280(1):448-57.
2005: Yasuaki Kabe; Joe Yamada; Hitoshi Uga; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.
Molecular and cellular biology 2005;25(1):512-22.
2004: Masaki Hiramoto; Yutaka Kawakami; Ryusuke Nabeshima; Daisuke Shima; Hiroshi Handa; Shin Aizawa
Identification of differentiation-inducing activity produced by human bone marrow stromal cell line LP101.
International journal of molecular medicine 2004;14(5):867-72.
2004: Tatsuya Zenkoh; Hidetaka Hatori; Hiroshi Tanaka; Makoto Hasegawa; Mamoru Hatakeyama; Yasuaki Kabe; Hiroyuki Setoi; Haruma Kawaguchi; Hiroshi Handa; Takashi Takahashi
Design and synthesis of a solid-supported FR225659 derivative for its receptor screening.
Organic letters 2004;6(14):2477-80.
2004: Hidetaka Hatori; Tatsuya Zenkoh; Motoo Kobayashi; Yoshihiro Ohtsu; Nobuharu Shigematsu; Hiroyuki Setoi; Motohiro Hino; Hiroshi Handa
FR225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads.
The Journal of antibiotics 2004;57(7):456-61.
2004: Chika Sawa; Eduard Nedea; Nevan J Krogan; Tadashi Wada; Hiroshi Handa; Jack Greenblatt; Stephen Buratowski
Bromodomain factor 1 (Bdf1) is phosphorylated by protein kinase CK2.
Molecular and cellular biology 2004;24(11):4734-42.
2004: Subhrangsu S Mandal; Chun Chu; Tadashi Wada; Hiroshi Handa; Aaron J Shatkin; Danny Reinberg
Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7572-7.
2004: Masaki Endoh; Wenyan Zhu; Jun Hasegawa; Hajime Watanabe; Dong-Ki Kim; Masatoshi Aida; Naoto Inukai; Takashi Narita; Tomoko Yamada; Akiko Furuya; Hiroe Sato; Yuki Yamaguchi; Subhrangsu S Mandal; Danny Reinberg; Tadashi Wada; Hiroshi Handa
Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.
Molecular and cellular biology 2004;24(8):3324-36.
2004: Song-iee Han; Masa-Aki Kawano; Ken-ichiro Ishizu; Hajime Watanabe; Makoto Hasegawa; Shin-nosuke Kanesashi; Yang-Su Kim; Akira Nakanishi; Kohsuke Kataoka; Hiroshi Handa
Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535.
Virology 2004;320(1):144-55.
2004: Naoto Inukai; Yuki Yamaguchi; Isao Kuraoka; Tomoko Yamada; Sachiko Kamijo; Junko Kato; Kiyoji Tanaka; Hiroshi Handa
A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis.
The Journal of biological chemistry 2004;279(9):8190-5.
2003: Shin-nosuke Kanesashi; Ken-ichiro Ishizu; Masa-aki Kawano; Song-iee Han; Satoru Tomita; Hajime Watanabe; Kohsuke Kataoka; Hiroshi Handa
Simian virus 40 VP1 capsid protein forms polymorphic assemblies in vitro.
The Journal of general virology 2003;84(Pt 7):1899-905.
2003: Dong-Ki Kim; Naoto Inukai; Tomoko Yamada; Akiko Furuya; Hiroe Sato; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(4):371-8.
2003: Daisuke Shima; Masato Yugami; Michiko Tatsuno; Tadashi Wada; Yuki Yamaguchi; Hiroshi Handa
Mechanism of H-8 inhibition of cyclin-dependent kinase 9: study using inhibitor-immobilized matrices.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(3):215-23.
2003: Takashi Narita; Yuki Yamaguchi; Keiichi Yano; Seiji Sugimoto; Sittinan Chanarat; Tadashi Wada; Dong-ki Kim; Jun Hasegawa; Masashi Omori; Naoto Inukai; Masaki Endoh; Tomoko Yamada; Hiroshi Handa
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
Molecular and cellular biology 2003;23(6):1863-73.
2003: Masashige Bando; Makoto Hasegawa; Yasunori Tsuboi; Yasunobu Miyake; Masashi Shiina; Mika Ito; Hiroshi Handa; Kazuo Nagai; Takao Kataoka
The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex.
The Journal of biological chemistry 2003;278(8):5786-93.
2003: Jun Hasegawa; Masaki Endou; Takashi Narita; Tomoko Yamada; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
A rapid purification method for human RNA polymerase II by two-step affinity chromatography.
Journal of biochemistry 2003;133(1):133-8.
2002: Kohsuke Kataoka; Song-iee Han; Setsuko Shioda; Momoki Hirai; Makoto Nishizawa; Hiroshi Handa
MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene.
The Journal of biological chemistry 2002;277(51):49903-10.
2002: Takeyuki Nishi; Noriaki Shimizu; Masaki Hiramoto; Iwao Sato; Yuki Yamaguchi; Makoto Hasegawa; Shin Aizawa; Hirotoshi Tanaka; Kohsuke Kataoka; Hajime Watanabe; Hiroshi Handa
Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo.
The Journal of biological chemistry 2002;277(46):44548-56.
2002: Yuki Yamaguchi; Sophie Deléhouzée; Hiroshi Handa
HIV and hepatitis delta virus: evolution takes different paths to relieve blocks in transcriptional elongation.
Microbes and infection / Institut Pasteur 2002;4(11):1169-75.
2002: Chika Sawa; Tatsufumi Yoshikawa; Fumihiko Matsuda-Suzuki; Sophie Deléhouzée; Masahide Goto; Hajime Watanabe; Jun-ichi Sawada; Kohsuke Kataoka; Hiroshi Handa
YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.
The Journal of biological chemistry 2002;277(25):22484-90.
2002: Yuki Yamaguchi; Naoto Inukai; Takashi Narita; Tadashi Wada; Hiroshi Handa
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.
Molecular and cellular biology 2002;22(9):2918-27.
2002: Masaki Hiramoto; Noriaki Shimizu; Takeyuki Nishi; Daisuke Shima; Shin Aizawa; Hirotoshi Tanaka; Mamoru Hatakeyama; Haruma Kawaguchi; Hiroshi Handa
High-performance affinity beads for identifying anti-NF-kappa B drug receptors.
Methods in enzymology 2002;353():81-8.
2001: T Yoshimatsu; A Saitoh; J N Ryu; Daisuke Shima; Hiroshi Handa; Masaki Hiramoto; Yutaka Kawakami; Shin Aizawa
Characterization of immortalized human chondrocytes originated from osteoarthritis cartilage.
International journal of molecular medicine 2001;8(4):345-51.
2001: Kohsuke Kataoka; Hiroshi Handa; M Nishizawa
Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds.
The Journal of biological chemistry 2001;276(36):34074-81.
2001: Yuki Yamaguchi; Julija Filipovska; Keiichi Yano; Akiko Furuya; Naoto Inukai; Takashi Narita; Tadashi Wada; Seiji Sugimoto; Maria M Konarska; Hiroshi Handa
Stimulation of RNA polymerase II elongation by hepatitis delta antigen.
Science (New York, N.Y.) 2001;293(5527):124-7.
2001: Yuki Yamaguchi; Takashi Narita; Naoto Inukai; Tadashi Wada; Hiroshi Handa
SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes.
Journal of biochemistry 2001;129(2):185-91.
2001: Ken-ichiro Ishizu; Hajime Watanabe; Song-iee Han; Shin-nosuke Kanesashi; M Hoque; H Yajima; Kohsuke Kataoka; Hiroshi Handa
Roles of disulfide linkage and calcium ion-mediated interactions in assembly and disassembly of virus-like particles composed of simian virus 40 VP1 capsid protein.
Journal of virology 2001;75(1):61-72.
2000: Noriaki Shimizu; K Sugimoto; J Tang; Takeyuki Nishi; I Sato; Masaki Hiramoto; Shin Aizawa; Mamoru Hatakeyama; R Ohba; Hidetaka Hatori; T Yoshikawa; F Suzuki; A Oomori; Hirotoshi Tanaka; Haruma Kawaguchi; Hajime Watanabe; Hiroshi Handa
High-performance affinity beads for identifying drug receptors.
Nature biotechnology 2000;18(8):877-81.
2000: Shin Aizawa; Noriaki Shimizu; Hiroshi Handa; Masaki Hiramoto; Hajime Hoshi; M Nagasu; Hitoshi Kanno; Y Nagasu; Y Imanishi
Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro.
Hematological oncology 2000;18(2):51-60.
2000: Tadashi Wada; G Orphanides; Jun Hasegawa; D K Kim; Daisuke Shima; Yuki Yamaguchi; A Fukuda; Hisatake Koji; S Oh; Danny Reinberg; Hiroshi Handa
FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.
Molecular cell 2000;5(6):1067-72.
2000: Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
[Regulatory mechanism of transcription elongation: DRB-sensitive elongation control machinery].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(9 Suppl):1476-83.
2000: Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
[Mechanism of basal transcription].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(9 Suppl):1473-5.
2000: S Satoh; M Hirota; T Noguchi; M Hijikata; Hiroshi Handa; K Shimotohno
Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells.
Virology 2000;270(2):476-87.
2000: Shin Aizawa; Masaki Hiramoto; Hajime Hoshi; K Toyama; Daisuke Shima; Hiroshi Handa
Establishment of stromal cell line from an MDS RA patient which induced an apoptotic change in hematopoietic and leukemic cells in vitro.
Experimental hematology 2000;28(2):148-55.
1999: M Hoque; Noriaki Shimizu; Ken-ichiro Ishizu; H Yajima; Fumio Arisaka; K Suzuki; Hajime Watanabe; Hiroshi Handa
Chimeric virus-like particle formation of adeno-associated virus.
Biochemical and biophysical research communications 1999;266(2):371-6.
1999: Jun-ichi Sawada; Noriaki Shimizu; F Suzuki; Chika Sawa; Masahide Goto; Makoto Hasegawa; Takeshi Imai; Hajime Watanabe; Hiroshi Handa
Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family.
The Journal of biological chemistry 1999;274(50):35475-82.
1999: Yasuaki Kabe; Masahide Goto; Daisuke Shima; Takeshi Imai; Tadashi Wada; K i Morohashi; M Shirakawa; Shigehisa Hirose; Hiroshi Handa
The role of human MBF1 as a transcriptional coactivator.
The Journal of biological chemistry 1999;274(48):34196-202.
1999: M Hoque; Ken-ichiro Ishizu; A Matsumoto; Song-iee Han; Fumio Arisaka; M Takayama; K Suzuki; K Kato; T Kanda; Hajime Watanabe; Hiroshi Handa
Nuclear transport of the major capsid protein is essential for adeno-associated virus capsid formation.
Journal of virology 1999;73(9):7912-5.
1999: Yuki Yamaguchi; T Takagi; Tadashi Wada; Keiichi Yano; Akiko Furuya; Seiji Sugimoto; Jun Hasegawa; Hiroshi Handa
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.
Cell 1999;97(1):41-51.
1999: Yuki Yamaguchi; Tadashi Wada; D Watanabe; T Takagi; J Hasegawa; Hiroshi Handa
Structure and function of the human transcription elongation factor DSIF.
The Journal of biological chemistry 1999;274(12):8085-92.
1999: Shin Aizawa; M Nakano; Osamu Iwase; Makoto Yaguchi; Masaki Hiramoto; Hajime Hoshi; Ryusuke Nabeshima; Daisuke Shima; Hiroshi Handa; K Toyama
Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro.
Leukemia research 1999;23(3):239-46.
1998: Tadashi Wada; T Takagi; Yuki Yamaguchi; D Watanabe; Hiroshi Handa
Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.
The EMBO journal 1998;17(24):7395-403.
1998: F Suzuki; Masahide Goto; Chika Sawa; S Ito; Hajime Watanabe; Jun-ichi Sawada; Hiroshi Handa
Functional interactions of transcription factor human GA-binding protein subunits.
The Journal of biological chemistry 1998;273(45):29302-8.
1998: Yuki Yamaguchi; Tadashi Wada; F Suzuki; T Takagi; J Hasegawa; Hiroshi Handa
Casein kinase II interacts with the bZIP domains of several transcription factors.
Nucleic acids research 1998;26(16):3854-61.
1998: Masaki Hiramoto; Shin Aizawa; Osamu Iwase; M Nakano; K Toyama; M Hoque; Ryusuke Nabeshima; A Kaidow; T Imai; Hajime Hoshi; Hiroshi Handa
Stimulatory effects of substance P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function.
International journal of molecular medicine 1998;1(2):347-54.
1998: Grant A Hartzog; Tadashi Wada; Hiroshi Handa; fred winston
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae.
Genes & development 1998;12(3):357-69.
1998: Tadashi Wada; T Takagi; Yuki Yamaguchi; A Ferdous; T Imai; S Hirose; Seiji Sugimoto; Keiichi Yano; Grant A Hartzog; fred winston; S Buratowski; Hiroshi Handa
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
Genes & development 1998;12(3):343-56.
1998: Masaki Hiramoto; Noriaki Shimizu; K Sugimoto; J Tang; Y Kawakami; M Ito; Shin Aizawa; Hirotoshi Tanaka; I Makino; Hiroshi Handa
Nuclear targeted suppression of NF-kappa B activity by the novel quinone derivative E3330.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):810-9.
1998: Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
Interplay between positive and negative elongation factors: drawing a new view of DRB.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(1):9-15.
1997: K Nakade; Hiroshi Handa; Kyosuke Nagata
Promoter structure of the MxA gene that confers resistance to influenza virus.
FEBS letters 1997;418(3):315-8.
1997: Ryusuke Nabeshima; Shin Aizawa; M Nakano; K Toyama; K Sugimoto; A Kaidow; T Imai; Hiroshi Handa
Effects of vesnarinone on the bone marrow stromal cell-dependent proliferation and differentiation of HL60 cells in vitro.
Experimental hematology 1997;25(6):509-15.
1997: T Imai; K Matsuda; T Shimojima; T Hashimoto; Yoshikazu Masuhiro; T Kitamoto; A Sugita; K Suzuki; H Matsumoto; Shoichi Masushige; Y Nogi; M Muramatsu; Hiroshi Handa; S Kato
ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors.
Biochemical and biophysical research communications 1997;233(3):765-9.
1997: Yuki Yamaguchi; Jun-ichi Sawada; M Yamada; Hiroshi Handa; N Azuma
Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(4):255-61.
1997: Shin Aizawa; M Nakano; Makoto Yaguchi; Yuzuru Kuriyama; Osamu Iwase; K Toyama; K Tanaka; Hajime Hoshi; K Sugimoto; A Kaido; T Imai; Ryusuke Nabeshima; Hiroshi Handa
Possible involvement of bone marrow stromal cells in agranulocytosis caused by vesnarinone treatment.
Acta haematologica 1997;98(3):140-6.
1996: H Yajima; A Kosukegawa; M M Hoque; T Shimojima; Ken-ichiro Ishizu; M Takayama; Y Sasaki; H Sakai; M Otsuka; S Inokuchi; Hiroshi Handa
Construction and characterization of a recombinant adenovirus vector carrying the human preproinsulin gene under the control of the metallothionein gene promoter.
Biochemical and biophysical research communications 1996;229(3):778-87.
1996: Chika Sawa; Masahide Goto; F Suzuki; H Watanabe; Jun-ichi Sawada; Hiroshi Handa
Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation.
Nucleic acids research 1996;24(24):4954-61.
1996: H Kawase; Mitsuru Okuwaki; M Miyaji; R Ohba; Hiroshi Handa; Yukio Ishimi; T Fujii-Nakata; A Kikuchi; Kyosuke Nagata
NAP-I is a functional homologue of TAF-I that is required for replication and transcription of the adenovirus genome in a chromatin-like structure.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(12):1045-56.
1996: Hiroshi Shimada; Tadashi Wada; Hiroshi Handa; Hiroyuki Ohta; H Mizoguchi; K Nishimura; Tatsuru Masuda; Y Shioi; Ken-ichiro Takamiya
A transcription factor with a leucine-zipper motif involved in light-dependent inhibition of expression of the puf operon in the photosynthetic bacterium Rhodobacter sphaeroides.
Plant & cell physiology 1996;37(4):515-22.
1996: Hiroshi Handa
[The structure and function of general transcription factor TFIIA].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1996;41(8 Suppl):1124-34.
1996: A Kosukegawa; Fumio Arisaka; M Takayama; H Yajima; A Kaidow; Hiroshi Handa
Purification and characterization of virus-like particles and pentamers produced by the expression of SV40 capsid proteins in insect cells.
Biochimica et biophysica acta 1996;1290(1):37-45.
1996: Tadashi Wada; T Takagi; Yuki Yamaguchi; H Kawase; M Hiramoto; A Ferdous; M Takayama; K A Lee; H C Hurst; Hiroshi Handa
Copurification of casein kinase II with transcription factor ATF/E4TF3.
Nucleic acids research 1996;24(5):876-84.
1996: F Momose; Hiroshi Handa; Kyosuke Nagata
Identification of host factors that regulate the influenza virus RNA polymerase activity.
Biochimie 1996;78(11-12):1103-8.
1996: K Watanabe; Hiroshi Handa; K Mizumoto; Kyosuke Nagata
Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein.
Journal of virology 1996;70(1):241-7.
1995: Masahide Goto; T Shimizu; Jun-ichi Sawada; Chika Sawa; H Watanabe; H Ichikawa; M Ohira; M Ohki; Hiroshi Handa
Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3.
Gene 1995;166(2):337-8.
1995: K Watanabe; F Momose; Hiroshi Handa; Kyosuke Nagata
Interaction between influenza virus proteins and pine cone antitumor substance that inhibits the virus multiplication.
Biochemical and biophysical research communications 1995;214(2):318-23.
1995: Kyosuke Nagata; H Kawase; Hiroshi Handa; Keiichi Yano; M Yamasaki; Yukio Ishimi; A Okuda; A Kikuchi; Ken Matsumoto
Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4279-83.
1995: Ken Matsumoto; Mitsuru Okuwaki; H Kawase; Hiroshi Handa; F Hanaoka; Kyosuke Nagata
Stimulation of DNA transcription by the replication factor from the adenovirus genome in a chromatin-like structure.
The Journal of biological chemistry 1995;270(16):9645-50.
1995: Tadashi Wada; H Watanabe; H Kawaguchi; Hiroshi Handa
DNA affinity chromatography.
Methods in enzymology 1995;254():595-604.
1995: Jun-ichi Sawada; Masahide Goto; H Watanabe; Hiroshi Handa; M C Yoshida
Regional mapping of two subunits of transcription factor E4TF1 to human chromosome.
Japanese journal of cancer research : Gann 1995;86(1):10-2.
1994: K Shimizu; Hiroshi Handa; S Nakada; Kyosuke Nagata
Regulation of influenza virus RNA polymerase activity by cellular and viral factors.
Nucleic acids research 1994;22(23):5047-53.
1994: Shin Aizawa; Makoto Yaguchi; M Nakano; K Toyama; S Inokuchi; T Imai; M Yasuda; Ryusuke Nabeshima; Hiroshi Handa
Hematopoietic supportive function of human bone marrow stromal cell lines established by a recombinant SV40-adenovirus vector.
Experimental hematology 1994;22(6):482-7.
1994: Jun-ichi Sawada; Masahide Goto; Chika Sawa; H Watanabe; Hiroshi Handa
Transcriptional activation through the tetrameric complex formation of E4TF1 subunits.
The EMBO journal 1994;13(6):1396-402.
1994: H Hojo; Makoto Yaguchi; M Nagasu; Shin Aizawa; M Nakano; Kenichi Harigaya; Hiroshi Handa; K Toyama
Establishment of a human thymic stromal cell line (R-3-4) and its adhesive capacity with T cells in vitro.
Hematologic pathology 1994;8(4):177-85.
1993: H Watanabe; Jun-ichi Sawada; K Yano; K Yamaguchi; Masahide Goto; Hiroshi Handa
cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs.
Molecular and cellular biology 1993;13(3):1385-91.
1992: T Wada; Hiroshi Handa
[Regulation of DNA replication and gene expression of adenovirus].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1992;37(14 Suppl):2511-8.
1992: Hiroshi Handa
[Purification of transcription factors by using DNA affinity latex particles].
Seikagaku. The Journal of Japanese Biochemical Society 1992;64(6):404-7.
1991: Shin Aizawa; Makoto Yaguchi; M Nakano; S Inokuchi; Hiroshi Handa; K Toyama
Establishment of a variety of human bone marrow stromal cell lines by the recombinant SV40-adenovirus vector.
Journal of cellular physiology 1991;148(2):245-51.