FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Christopher Handley

Research Profile

Chemicals & Drugs

Anatomy

Co-author Network

Publications

TOP 3
Tom Samiric; Jill Cook; Christopher J Handley; J Parkinson
Gene expression of matrix-degrading enzymes in patellar tendinopathy.
Shannon E Munteanu; Gerard V Zammit; Ayman Elzarka; Christopher J Handley; Karl Landorf; Hylton B Menz; Jason Deluca
Effectiveness of intra-articular hyaluronan (Synvisc, hylan G-F 20) for the treatment of first metatarsophalangeal joint osteoarthritis: a randomised placebo-controlled trial.
J Parkinson; Tom Samiric; Mirna Z Ilic; Jill Cook; Christopher J Handley
Involvement of proteoglycans in tendinopathy.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Christopher Handley (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Tom Samiric; Jill Cook; Christopher J Handley; J Parkinson
Gene expression of matrix-degrading enzymes in patellar tendinopathy.
British journal of sports medicine 2013;47(9):e2.
2011: Shannon E Munteanu; Gerard V Zammit; Ayman Elzarka; Christopher J Handley; Karl Landorf; Hylton B Menz; Jason Deluca
Effectiveness of intra-articular hyaluronan (Synvisc, hylan G-F 20) for the treatment of first metatarsophalangeal joint osteoarthritis: a randomised placebo-controlled trial.
Annals of the rheumatic diseases 2011;70(10):1838-41.
2011: J Parkinson; Tom Samiric; Mirna Z Ilic; Jill Cook; Christopher J Handley
Involvement of proteoglycans in tendinopathy.
Journal of musculoskeletal & neuronal interactions 2011;11(2):86-93.
2010: John Parkinson; Tom Samiric; Mirna Z Ilic; Jill Cook; Julian A Feller; Christopher J Handley
Change in proteoglycan metabolism is a characteristic of human patellar tendinopathy.
Arthritis and rheumatism 2010;62(10):3028-35.
2009: Tom Samiric; John Parkinson; Mirna Z Ilic; Jill Cook; Julian A Feller; Christopher J Handley
Changes in the composition of the extracellular matrix in patellar tendinopathy.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(4):230-6.
2009: Shannon E Munteanu; Hylton B Menz; Gerard V Zammit; Karl Landorf; Christopher J Handley; Ayman Elzarka; Jason Deluca
Efficacy of intra-articular hyaluronan (Synvisc(R)) for the treatment of osteoarthritis affecting the first metatarsophalangeal joint of the foot (hallux limitus): study protocol for a randomised placebo controlled trial.
Journal of foot and ankle research 2009;2():2.
2008: Mirna Z Ilic; B Martinac; Tom Samiric; Christopher J Handley
Effects of glucosamine on proteoglycan loss by tendon, ligament and joint capsule explant cultures.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(12):1501-8.
2007: Mirna Z Ilic; Charlotte J East; Fraser M Rogerson; Amanda J Fosang; Christopher J Handley
Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.
The Journal of biological chemistry 2007;282(52):37420-8.
2006: Tom Samiric; Mirna Z Ilic; Christopher J Handley
Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon.
The FEBS journal 2006;273(15):3479-88.
2006: Christopher J Handley; Tom Samiric; Mirna Z Ilic
Structure, metabolism, and tissue roles of chondroitin sulfate proteoglycans.
Advances in pharmacology (San Diego, Calif.) 2006;53():219-32.
2005: Mirna Z Ilic; Phillip Carter; Alicia Tyndall; Jayesh Dudhia; Christopher J Handley
Proteoglycans and catabolic products of proteoglycans present in ligament.
The Biochemical journal 2005;385(Pt 2):381-8.
2004: Tom Samiric; Mirna Z Ilic; Christopher J Handley
Large aggregating and small leucine-rich proteoglycans are degraded by different pathways and at different rates in tendon.
European journal of biochemistry / FEBS 2004;271(17):3612-20.
2004: Tom Samiric; Mirna Z Ilic; Christopher J Handley
Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon.
Matrix biology : journal of the International Society for Matrix Biology 2004;23(2):127-40.
2003: Mirna Z Ilic; B Martinac; Christopher J Handley
Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(8):613-22.
2003: Mireille N Vankemmelbeke; Gavin C Jones; Cyprianne Fowles; Mirna Z Ilic; Christopher J Handley; Anthony J Day; C Graham Knight; John S Mort; David J Buttle
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.
European journal of biochemistry / FEBS 2003;270(11):2394-403.
2002: Christopher J Handley; Gavin M Winter; Mirna Z Ilic; Jacqueline M Ross; C Anthony Poole; H Clem Robinson
Distribution of newly synthesized aggrecan in explant cultures of bovine cartilage treated with retinoic acid.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(7):579-92.
2002: Shannon E Munteanu; Mirna Z Ilic; Christopher J Handley
Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(5):429-40.
2001: Christopher J Handley; M T Mok; Mirna Z Ilic; Clair Adcocks; David J Buttle; H Clem Robinson
Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH.
Matrix biology : journal of the International Society for Matrix Biology 2001;20(8):543-53.
2001: Mireille N Vankemmelbeke; Ingunn Holen; A G Wilson; Mirna Z Ilic; Christopher J Handley; GS Kelner; M Clark; C Liu; Richard A Maki; D Burnett; David J Buttle
Expression and activity of ADAMTS-5 in synovium.
European journal of biochemistry / FEBS 2001;268(5):1259-68.
2000: Shannon E Munteanu; Mirna Z Ilic; Christopher J Handley
Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures.
Arthritis and rheumatism 2000;43(10):2211-8.
2000: Mirna Z Ilic; Mireille N Vankemmelbeke; Ingunn Holen; David J Buttle; H Clem Robinson; Christopher J Handley
Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(3):257-65.
2000: A D Winter; M A Campbell; H Clem Robinson; Christopher J Handley
Catabolism of newly synthesized decorin by explant cultures of bovine ligament.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(2):129-38.
1999: Mireille N Vankemmelbeke; Mirna Z Ilic; Christopher J Handley; C G Knight; David J Buttle
Coincubation of bovine synovial or capsular tissue with cartilage generates a soluble "Aggrecanase" activity.
Biochemical and biophysical research communications 1999;255(3):686-91.
1999: A M Tester; Mirna Z Ilic; H Clem Robinson; Christopher J Handley
Metabolic processing of newly synthesized link protein in bovine articular cartilage explant cultures.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(1):65-74.
1998: Mirna Z Ilic; H Clem Robinson; Christopher J Handley
Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan.
The Journal of biological chemistry 1998;273(28):17451-8.
1998: G M Winter; C Anthony Poole; Mirna Z Ilic; Jacqueline M Ross; H Clem Robinson; Christopher J Handley
Identification of distinct metabolic pools of aggrecan and their relationship to type VI collagen in the chondrons of mature bovine articular cartilage explants.
Connective tissue research 1998;37(3-4):277-93.
1997: David J Buttle; A Fowles; Mirna Z Ilic; Christopher J Handley
"Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.
Molecular pathology : MP 1997;50(3):153-9.
1996: C Karopoulos; Merrill J Rowley; Mirna Z Ilic; Christopher J Handley
Presence of antibodies to native G1 domain of aggrecan core protein in synovial fluids from patients with various joint diseases.
Arthritis and rheumatism 1996;39(12):1990-7.
1996: Z Yang; M J deVeer; E E Gardiner; Rodney J Devenish; Christopher J Handley; J R Underwood; H Clem Robinson
Rabbit polymorphonuclear neutrophils form 35S-labeled S-sulfo-calgranulin C when incubated with inorganic [35S]sulfate.
The Journal of biological chemistry 1996;271(33):19802-9.
1996: M A Campbell; A M Tester; Christopher J Handley; G J Checkley; G L Chow; A E Cant; A D Winter; W E Cain
Characterization of a large chondroitin sulfate proteoglycan present in bovine collateral ligament.
Archives of biochemistry and biophysics 1996;329(2):181-90.
1996: M A Campbell; A D Winter; Mirna Z Ilic; Christopher J Handley
Catabolism and loss of proteoglycans from cultures of bovine collateral ligament.
Archives of biochemistry and biophysics 1996;328(1):64-72.
1995: Mirna Z Ilic; S R Haynes; G M Winter; Christopher J Handley
Kinetics of release of aggrecan from explant cultures of bovine cartilage from different sources and from animals of different ages.
Acta orthopaedica Scandinavica. Supplementum 1995;266():33-7.
1995: Mirna Z Ilic; M T Mok; O D Williamson; M A Campbell; C E Hughes; Christopher J Handley
Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid.
Archives of biochemistry and biophysics 1995;322(1):22-30.
1995: C Karopoulos; Merrill J Rowley; Christopher J Handley; R A Strugnell
Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity.
Journal of autoimmunity 1995;8(2):235-48.
1995: G J Parker; Christopher J Handley; H Clem Robinson
An assay for galactosyltransferase-I activity in articular cartilage.
Analytical biochemistry 1995;226(1):154-60.
1995: C K Ng; Christopher J Handley; BN Preston; H Clem Robinson; S Bolis; G Parker
Effect of exogenous hyaluronan and hyaluronan oligosaccharides on hyaluronan and aggrecan synthesis and catabolism in adult articular cartilage explants.
Archives of biochemistry and biophysics 1995;316(1):596-606.
1994: F Kleftogiannis; Christopher J Handley; M A Campbell
Characterization of extracellular matrix macromolecules from bovine synovial capsule.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(3):365-74.
1994: E E Gardiner; S S Mok; A Sriratana; H Clem Robinson; B J Veitch; D A Lowther; Christopher J Handley
Polymorphonuclear neutrophils release 35S-labelled proteoglycans into cartilage during frustrated phagocytosis.
European journal of biochemistry / FEBS 1994;221(2):871-9.
1993: David J Buttle; Christopher J Handley; Mirna Z Ilic; J Saklatvala; M Murata; Alan J Barrett
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation.
Arthritis and rheumatism 1993;36(12):1709-17.
1993: C Karopoulos; Merrill J Rowley; Christopher J Handley
Intrasynovial levels of sulphated glycosaminoglycans and autoantibodies to type II collagen in rheumatoid arthritis: a correlative analysis.
Rheumatology international 1993;13(1):15-20.
1992: A J Curtis; Rodney J Devenish; Christopher J Handley
Modulation of aggrecan and link-protein synthesis in articular cartilage.
The Biochemical journal 1992;288 ( Pt 3)():721-6.
1992: E E Gardiner; H Clem Robinson; A Sriratana; S S Mok; D A Lowther; Christopher J Handley
Synthesis of 35S-labelled macromolecules by polymorphonuclear neutrophils. Evidence for the production of [35S]sulphite which can modify both endogenous and exogenous proteins.
The Biochemical journal 1992;288 ( Pt 2)():577-83.
1992: C K Ng; Christopher J Handley; BN Preston; H Clem Robinson
The extracellular processing and catabolism of hyaluronan in cultured adult articular cartilage explants.
Archives of biochemistry and biophysics 1992;298(1):70-9.
1992: A J Curtis; C K Ng; Christopher J Handley; H Clem Robinson
Effect of insulin-like growth factor-I on the synthesis and distribution of link protein and hyaluronan in explant cultures of articular cartilage.
Biochimica et biophysica acta 1992;1135(3):309-17.
1992: Mirna Z Ilic; Christopher J Handley; H Clem Robinson; M T Mok
Mechanism of catabolism of aggrecan by articular cartilage.
Archives of biochemistry and biophysics 1992;294(1):115-22.
1992: M T Mok; Mirna Z Ilic; Christopher J Handley; H Clem Robinson
Cleavage of proteoglycan aggregate by leucocyte elastase.
Archives of biochemistry and biophysics 1992;292(2):442-7.
1991: M Katrantzis; Mark Baker; Christopher J Handley; D A Lowther
The oxidant hypochlorite (OCl-), a product of the myeloperoxidase system, degrades articular cartilage proteoglycan aggregate.
Free radical biology & medicine 1991;10(2):101-9.
1990: Mirna Z Ilic; Christopher J Handley; H Clem Robinson
The N-terminal sequence of the large proteoglycan of articular cartilage.
Biochemistry international 1990;21(5):977-86.
1990: N J Hey; Christopher J Handley; C K Ng; B W Oakes
Characterization and synthesis of macromolecules by adult collateral ligament.
Biochimica et biophysica acta 1990;1034(1):73-80.
1989: S Bolis; Christopher J Handley; Wayne D Comper
Passive loss of proteoglycan from articular cartilage explants.
Biochimica et biophysica acta 1989;993(2-3):157-67.
1989: C K Ng; Christopher J Handley; R M Mason; H Clem Robinson
Synthesis of hyaluronate in cultured bovine articular cartilage.
The Biochemical journal 1989;263(3):761-7.
1989: M A Campbell; Christopher J Handley; S E D'Souza
Turnover of proteoglycans in articular-cartilage cultures. Characterization of proteoglycans released into the medium.
The Biochemical journal 1989;259(1):21-5.
1988: R A Strugnell; T Kent; Christopher J Handley; S Faine
Experimental syphilitic orchitis. Relationship between Treponema pallidum infection and testis synthesis of proteoglycans.
The American journal of pathology 1988;133(1):110-7.
1988: A J Fosang; Christopher J Handley
Connective tissue remodelling in the ovine cervix during pregnancy and at term.
Connective tissue research 1988;17(4):277-85.
1987: M A Campbell; Christopher J Handley
The effect of retinoic acid on proteoglycan turnover in bovine articular cartilage cultures.
Archives of biochemistry and biophysics 1987;258(1):143-55.
1987: Wayne D Comper; L Pratt; Christopher J Handley; Gregory Harper
Cell transport in model extracellular matrices.
Archives of biochemistry and biophysics 1987;252(1):60-70.
1986: D J McQuillan; Christopher J Handley; M A Campbell; S Bolis; V E Milway; A C Herington
Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage.
The Biochemical journal 1986;240(2):423-30.
1986: D J McQuillan; Christopher J Handley; H Clem Robinson
Control of proteoglycan biosynthesis. Further studies on the effect of serum on cultured bovine articular cartilage.
The Biochemical journal 1986;237(3):741-7.
1986: R A Strugnell; Christopher J Handley; L P Drummond; S Faine
Characterization of the proteoglycans synthesized by rabbit testis in response to infection by Treponema pallidum.
The American journal of pathology 1986;124(2):216-25.
1986: D J McQuillan; Christopher J Handley; H Clem Robinson; K Ng; C Tzaicos
The relation of RNA synthesis to chondroitin sulphate biosynthesis in cultured bovine cartilage.
The Biochemical journal 1986;235(2):499-505.
1985: Christopher J Handley; D A Lowther; D J McQuillan
The structure and synthesis of proteoglycans of articular cartilage.
Cell biology international reports 1985;9(9):753-82.
1985: S Byers; Christopher J Handley; D A Lowther; A Sriratana
Carrageenin-induced arthritis. VI. Alterations in amino acid transport by articular cartilage in acute inflammatory arthritis.
Annals of the rheumatic diseases 1985;44(7):477-84.
1985: J S Bartholomew; Christopher J Handley; D A Lowther
The effects of trypsin treatment on proteoglycan biosynthesis by bovine articular cartilage.
The Biochemical journal 1985;227(2):429-37.
1984: D J McQuillan; Christopher J Handley; H Clem Robinson; K Ng; C Tzaicos; P R Brooks; D A Lowther
The relation of protein synthesis to chondroitin sulphate biosynthesis in cultured bovine cartilage.
The Biochemical journal 1984;224(3):977-88.
1984: M A Campbell; Christopher J Handley; V C Hascall; R A Campbell; D A Lowther
Turnover of proteoglycans in cultures of bovine articular cartilage.
Archives of biochemistry and biophysics 1984;234(1):275-89.
1984: J S Bartholomew; D A Lowther; Christopher J Handley
Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture.
Arthritis and rheumatism 1984;27(8):905-12.
1984: A J Fosang; Christopher J Handley; V Santer; D A Lowther; G D Thorburn
Pregnancy-related changes in the connective tissue of the ovine cervix.
Biology of reproduction 1984;30(5):1223-35.
1984: E J Bates; D A Lowther; Christopher J Handley
Oxygen free-radicals mediate an inhibition of proteoglycan synthesis in cultured articular cartilage.
Annals of the rheumatic diseases 1984;43(3):462-9.
1984: R A Strugnell; Christopher J Handley; L Drummond; S Faine; D A Lowther; S R Graves
Polyanions in syphilis: evidence that glycoproteins and macromolecules resembling glycosaminoglycans are synthesised by host tissues in response to infection with Treponema pallidum.
The British journal of venereal diseases 1984;60(2):75-82.
1984: R A Strugnell; Christopher J Handley; D A Lowther; S Faine; S R Graves
Treponema pallidum does not synthesise in vitro a capsule containing glycosaminoglycans or proteoglycans.
The British journal of venereal diseases 1984;60(1):8-13.
1984: M T De Witt; Christopher J Handley; B W Oakes; D A Lowther
In vitro response of chondrocytes to mechanical loading. The effect of short term mechanical tension.
Connective tissue research 1984;12(2):97-109.
1983: V C Hascall; Christopher J Handley; D J McQuillan; G K Hascall; H Clem Robinson; D A Lowther
The effect of serum on biosynthesis of proteoglycans by bovine articular cartilage in culture.
Archives of biochemistry and biophysics 1983;224(1):206-23.
1983: S Byers; Christopher J Handley; D A Lowther
Transport of neutral amino acids by adult articular cartilage.
Connective tissue research 1983;11(4):321-30.
1981: G Speight; Christopher J Handley; D A Lowther
Effect of dibutyryl cyclic AMP on the sulphation of proteoglycans by chondrocytes.
Biochimica et biophysica acta 1981;672(1):89-97.
1980: Christopher J Handley; G Speight; H Clem Robinson; D A Lowther
Molecular size distribution of proteoglycan subunits and glycosaminoglycans synthesized by chondrocytes under conditions of reduced proteoglycan synthesis.
Biochimica et biophysica acta 1980;631(1):124-9.
1980: Christopher J Handley; G Speight; K M Leyden; D A Lowther
Extracellular matrix metabolism by chondrocytes. 7. Evidence that L-glutamine is an essential amino acid for chondrocytes and other connective tissue cells.
Biochimica et biophysica acta 1980;627(3):324-31.