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Patrick Hanna

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Xin Zhou; Naixia Zhang; Li Liu; Kylie J Walters; Patrick E Hanna; Carston R Wagner
Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190.
Li Liu; Carston R Wagner; Patrick E Hanna
Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines.
Li Liu; Carston R Wagner; Patrick E Hanna
Human arylamine N-acetyltransferase 1: in vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines.

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2009: Xin Zhou; Naixia Zhang; Li Liu; Kylie J Walters; Patrick E Hanna; Carston R Wagner
Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190.
The FEBS journal 2009;276(23):6928-41.
2009: Li Liu; Carston R Wagner; Patrick E Hanna
Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines.
Chemical research in toxicology 2009;22(12):1962-74.
2008: Li Liu; Carston R Wagner; Patrick E Hanna
Human arylamine N-acetyltransferase 1: in vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines.
Chemical research in toxicology 2008;21(10):2005-16.
2007: Li Liu; Annette Von Vett; Naixia Zhang; Kylie J Walters; Carston R Wagner; Patrick E Hanna
Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2.
Chemical research in toxicology 2007;20(9):1300-8.
2006: Naixia Zhang; Li Liu; Fen Liu; Carston R Wagner; Patrick E Hanna; Kylie J Walters
NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity.
Journal of molecular biology 2006;363(1):188-200.
2006: Fen Liu; Naixia Zhang; Xin Zhou; Patrick E Hanna; Carston R Wagner; Deanna M Koepp; Kylie J Walters
Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation.
Journal of molecular biology 2006;361(3):482-92.
2005: Haiqing Wang; Li Liu; Patrick E Hanna; Carston R Wagner
Catalytic mechanism of hamster arylamine N-acetyltransferase 2.
Biochemistry 2005;44(33):11295-306.
2005: Haiqing Wang; Gregory M Vath; Akane Kawamura; Caleb A Bates; Edith Sim; Patrick E Hanna; Carston R Wagner
Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
The protein journal 2005;24(2):65-77.
2005: Haiqing Wang; Carston R Wagner; Patrick E Hanna
Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes.
Chemical research in toxicology 2005;18(2):183-97.
2005: Akane Kawamura; James Graham; Adeel Mushtaq; Stefanos A Tsiftsoglou; Gregory M Vath; Patrick E Hanna; Carston R Wagner; Edith Sim
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
Biochemical pharmacology 2005;69(2):347-59.
2004: Haiqing Wang; Gregory M Vath; Kara J Gleason; Patrick E Hanna; Carston R Wagner
Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies.
Biochemistry 2004;43(25):8234-46.
2004: Zhijun Guo; Carston R Wagner; Patrick E Hanna
Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene.
Chemical research in toxicology 2004;17(3):275-86.
2004: Haiqing Wang; Zhijun Guo; Gregory M Vath; Carston R Wagner; Patrick E Hanna
Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents.
The protein journal 2004;23(2):153-66.
2003: Zhijun Guo; Gregory M Vath; Carston R Wagner; Patrick E Hanna
Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene.
Journal of protein chemistry 2003;22(7-8):631-42.
1998: K R Sticha; C P Bergstrom; Carston R Wagner; Patrick E Hanna
Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases: bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene.
Biochemical pharmacology 1998;56(1):47-59.
1997: K R Sticha; C A Sieg; C P Bergstrom; Patrick E Hanna; Carston R Wagner
Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein.
Protein expression and purification 1997;10(1):141-53.
1996: Carston R Wagner; C P Bergstrom; K R Koning; Patrick E Hanna
Arylamine N-acetyltransferases. Expression in Escherichia coli, purification, and substrate specificities of recombinant hamster monomorphic and polymorphic isozymes.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(2):245-53.
1995: C P Bergstrom; Carston R Wagner; D K Ann; Patrick E Hanna
Hamster monomorphic arylamine N-acetyltransferase: expression in Escherichia coli and purification.
Protein expression and purification 1995;6(1):45-55.
1994: M J Wick; Patrick E Hanna
Inactivation of hamster monomorphic N-acetyltransferase by vinyl fluorenyl ketone.
Biochemical pharmacology 1994;48(9):1835-8.
1994: L W Boteju; Patrick E Hanna
Arylamine-nucleoside adduct formation: evidence for arylnitrene involvement in the reactions of an N-acetoxyarylamine.
Chemical research in toxicology 1994;7(5):684-9.
1994: Patrick E Hanna
N-acetyltransferases, O-acetyltransferases, and N,O-acetyltransferases: enzymology and bioactivation.
Advances in pharmacology (San Diego, Calif.) 1994;27():401-30.
1993: L W Boteju; Patrick E Hanna
Bioactivation of N-hydroxy-2-acetylaminofluorenes by N,O-acyltransferase: substituent effects on covalent binding to DNA.
Carcinogenesis 1993;14(8):1651-7.
1992: J R Babson; N E Gavitt; L W Boteju; Patrick E Hanna
Comparative toxicity and mutagenicity of N-hydroxy-2-acetylaminofluorene and 7-acetyl-N-hydroxy-2-acetylaminofluorene in human lymphoblasts.
Mutation research 1992;269(1):73-8.
1992: H G Cheon; L W Boteju; Patrick E Hanna
Affinity alkylation of hamster hepatic arylamine N-acetyltransferases: isolation of a modified cysteine residue.
Molecular pharmacology 1992;42(1):82-93.
1992: H G Cheon; Patrick E Hanna
Effect of group-selective modification reagents on arylamine N-acetyltransferase activities.
Biochemical pharmacology 1992;43(10):2255-68.
1990: M J Wick; H M Yeh; Patrick E Hanna
An isozyme-selective affinity label for rat hepatic acetyltransferases.
Biochemical pharmacology 1990;40(6):1389-98.
1990: Patrick E Hanna; A M el-Ghandour; M E McCormack
Analogues of N-hydroxy-4-acetylaminobiphenyl as substrates and inactivators of hamster hepatic acetyltransferases.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(7):739-51.
1990: M J Wick; Patrick E Hanna
Bioactivation of N-arylhydroxamic acids by rat hepatic N-acetyltransferase. Detection of multiple enzyme forms by mechanism-based inactivation.
Biochemical pharmacology 1990;39(6):991-1003.
1988: M J Wick; I B Jantan; Patrick E Hanna
Irreversible inhibition of rat hepatic transacetylase activity by N-arylhydroxamic acids.
Biochemical pharmacology 1988;37(7):1225-31.
1988: T J Smith; Patrick E Hanna
Hepatic N-acetyltransferases: selective inactivation in vivo by a carcinogenic N-arylhydroxamic acid.
Biochemical pharmacology 1988;37(3):427-34.