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Ewald Hannappel

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Chemicals & Drugs

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Jana Knop; Christine App; Ewald Hannappel
Antibodies in research of thymosin β4: investigation of cross-reactivity and influence of fixatives.
Christine App; Jana Knop; Hans Georg Mannherz; Ewald Hannappel
Identification of interaction partners of β-thymosins: application of thymosin β4 labeled by transglutaminase.
Ewald Hannappel
Thymosin beta4 and its posttranslational modifications.

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All Publications

2012: Jana Knop; Christine App; Ewald Hannappel
Antibodies in research of thymosin β4: investigation of cross-reactivity and influence of fixatives.
Annals of the New York Academy of Sciences 2012;1270():105-11.
2012: Christine App; Jana Knop; Hans Georg Mannherz; Ewald Hannappel
Identification of interaction partners of β-thymosins: application of thymosin β4 labeled by transglutaminase.
Annals of the New York Academy of Sciences 2012;1270():98-104.
2010: Ewald Hannappel
Thymosin beta4 and its posttranslational modifications.
Annals of the New York Academy of Sciences 2010;1194():27-35.
2009: Hans Georg Mannherz; Ewald Hannappel
The beta-thymosins: intracellular and extracellular activities of a versatile actin binding protein family.
Cell motility and the cytoskeleton 2009;66(10):839-51.
2008: Rabea Hinkel; Chiraz El-Aouni; Tonia Olson; Jan Horstkotte; Stefan Mayer; Sebastian Müller; Michael Willhauck; Christine Spitzweg; Franz-Josef Gildehaus; Wolfgang Münzing; Ewald Hannappel; Ildiko Bock-Marquette; J Michael DiMaio; Antonis K Hatzopoulos; Peter Boekstegers; Christian Kupatt
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection.
Circulation 2008;117(17):2232-40.
2007: Elena Barnaeva; Agladze Nadezhda; Ewald Hannappel; Maria H Sjogren; Marcos Rojkind
Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells.
Annals of the New York Academy of Sciences 2007;1112():154-60.
2007: Robert E Zoubek; Ewald Hannappel
Subcellular distribution of thymosin beta4.
Annals of the New York Academy of Sciences 2007;1112():442-50.
2007: Robert E Zoubek; Ewald Hannappel
Influence of the N terminus and the actin-binding motif of thymosin beta4 on its interaction with G-actin.
Annals of the New York Academy of Sciences 2007;1112():435-41.
2007: S Bodendorf; G Born; Ewald Hannappel
Determination of thymosin beta4 and protein in human wound fluid after abdominal surgery.
Annals of the New York Academy of Sciences 2007;1112():418-24.
2007: Thomas Huff; Christian S G Müller; Ewald Hannappel
Thymosin beta4 is not always the main beta-thymosin in mammalian platelets.
Annals of the New York Academy of Sciences 2007;1112():451-7.
2007: Ewald Hannappel
beta-Thymosins.
Annals of the New York Academy of Sciences 2007;1112():21-37.
2007: Carmen Villmann; Barbara Sandmeier; Silke Seeber; Ewald Hannappel; Monika Pischetsrieder; Cord-Michael Becker
Myelin proteolipid protein (PLP) as a marker antigen of central nervous system contaminations for routine food control.
Journal of agricultural and food chemistry 2007;55(17):7114-23.
2005: allan l goldstein; Ewald Hannappel; Hynda K Kleinman
Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues.
Trends in molecular medicine 2005;11(9):421-9.
2004: Thomas Huff; Olaf Rosorius; Angela M Otto; Christian S G Müller; Edda Ballweber; Ewald Hannappel; Hans Georg Mannherz
Nuclear localisation of the G-actin sequestering peptide thymosin beta4.
Journal of cell science 2004;117(Pt 22):5333-41.
2004: Wilairat Leeanansaksiri; Shirley K DeSimone; Thomas Huff; Ewald Hannappel; Thomas F Huff
Thymosin beta 4 and its N-terminal tetrapeptide, AcSDKP, inhibit proliferation, and induce dysplastic, non-apoptotic nuclei and degranulation of mast cells.
Chemistry & biodiversity 2004;1(7):1091-100.
2003: Deborah Philp; Thomas Huff; Yong Song Gho; Ewald Hannappel; Hynda K Kleinman
The actin binding site on thymosin beta4 promotes angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2103-5.
2003: Christian S G Müller; Thomas Huff; Ewald Hannappel
Reduction of thymosin beta4 and actin in HL60 cells during apoptosis is preceded by a decrease of their mRNAs.
Molecular and cellular biochemistry 2003;250(1-2):179-88.
2003: Ewald Hannappel; Thomas Huff
The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function.
Vitamins and hormones 2003;66():257-96.
2002: Angela M Otto; Christian S G Müller; Thomas Huff; Ewald Hannappel
Chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells.
Journal of cancer research and clinical oncology 2002;128(5):247-56.
2002: Thomas Huff; Angela M Otto; Christian S G Müller; Markus Meier; Ewald Hannappel
Thymosin beta4 is released from human blood platelets and attached by factor XIIIa (transglutaminase) to fibrin and collagen.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(7):691-6.
2002: Edda Ballweber; Ewald Hannappel; Thomas Huff; Harald Stephan; Markus Haener; Nicole Taschner; Daniel Stoffler; Ueli Aebi; Hans Georg Mannherz
Polymerisation of chemically cross-linked actin:thymosin beta(4) complex to filamentous actin: alteration in helical parameters and visualisation of thymosin beta(4) binding on F-actin.
Journal of molecular biology 2002;315(4):613-25.
2001: Thomas Huff; Christian S G Müller; Angela M Otto; R Netzker; Ewald Hannappel
beta-Thymosins, small acidic peptides with multiple functions.
The international journal of biochemistry & cell biology 2001;33(3):205-20.
1999: Thomas Huff; Edda Ballweber; Andreas Humeny; Thomas Bonk; Cord-Michael Becker; Christian S G Müller; Hans Georg Mannherz; Ewald Hannappel
Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescent dansylcadaverine does not abolish interaction with G-actin.
FEBS letters 1999;464(1-2):14-20.
1998: HP Stuible; Sandra Meier; C Wagner; Ewald Hannappel; Eckhart Schweizer
A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein.
The Journal of biological chemistry 1998;273(35):22334-9.
1998: Thomas Huff; G Cappelletti; Ewald Hannappel
The dipyridyls paraquat and diquat attenuate the interaction of G-actin with thymosin beta4.
FEBS letters 1998;425(3):495-8.
1998: Edda Ballweber; K Giehl; Ewald Hannappel; Thomas Huff; Brigitte M Jockusch; Hans Georg Mannherz
Plant profilin induces actin polymerization from actin : beta-thymosin complexes and competes directly with beta-thymosins and with negative co-operativity with DNase I for binding to actin.
FEBS letters 1998;425(2):251-5.
1997: Edda Ballweber; Ewald Hannappel; Thomas Huff; Hans Georg Mannherz
Mapping the binding site of thymosin beta4 on actin by competition with G-actin binding proteins indicates negative co-operativity between binding sites located on opposite subdomains of actin.
The Biochemical journal 1997;327 ( Pt 3)():787-93.
1997: Thomas Huff; Christian S G Müller; Ewald Hannappel
C-terminal truncation of thymosin beta10 by an intracellular protease and its influence on the interaction with G-actin studied by ultrafiltration.
FEBS letters 1997;414(1):39-44.
1996: J Armesto; Ewald Hannappel; K Leopold; W Fischer; R Bublitz; L Langer; G A Cumme; Anton Horn
Microheterogeneity of the hydrophobic and hydrophilic part of the glycosylphosphatidylinositol anchor of alkaline phosphatase from calf intestine.
European journal of biochemistry / FEBS 1996;238(1):259-69.
1995: T Behr; Wolfgang Becker; Ewald Hannappel; David M Goldenberg; F Wolf
Targeting of liver metastases of colorectal cancer with IgG, F(ab')2, and Fab' anti-carcinoembryonic antigen antibodies labeled with 99mTc: the role of metabolism and kinetics.
Cancer research 1995;55(23 Suppl):5777s-5785s.
1995: Thomas Huff; D Zerzawy; Ewald Hannappel
Interactions of beta-thymosins, thymosin beta 4-sulfoxide, and N-terminally truncated thymosin beta 4 with actin studied by equilibrium centrifugation, chemical cross-linking and viscometry.
European journal of biochemistry / FEBS 1995;230(2):650-7.
1995: Michael Küchle; Nhung X Nguyen; Ewald Hannappel; Gottfried Naumann
The blood-aqueous barrier in eyes with pseudoexfoliation syndrome.
Ophthalmic research 1995;27 Suppl 1():136-42.
1994: T Behr; Wolfgang Becker; Ewald Hannappel; F Wolf
Structural modifications of monoclonal antibodies following direct versus indirect labelling with 99Tcm: does fragmentation really occur?
Nuclear medicine communications 1994;15(11):865-70.
1994: Michael Küchle; Nhung X Nguyen; Ewald Hannappel; W Beck; S T Ho; Gottfried Naumann
[Tyndallometry with the laser flare cell meter and biochemical protein determination in the aqueous humor of eyes with pseudoexfoliation syndrome].
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 1994;91(5):578-84.
1994: Edda Ballweber; Ewald Hannappel; B Niggemeyer; Hans Georg Mannherz
Induction of the polymerization of actin from the actin:thymosin beta 4 complex by phalloidin, skeletal myosin subfragment 1, chicken intestinal myosin I and free ends of filamentous actin.
European journal of biochemistry / FEBS 1994;223(2):419-26.
1994: Michael Küchle; T S Ho; Nhung X Nguyen; Ewald Hannappel; Gottfried Naumann
Protein quantification and electrophoresis in aqueous humor of pseudoexfoliation eyes.
Investigative ophthalmology & visual science 1994;35(2):748-52.
1993: R Bublitz; J Armesto; E Hoffmann-Blume; M Schulze; Heidrun Rhode; Anton Horn; S Aulwurm; Ewald Hannappel; W Fischer
Heterogeneity of glycosylphosphatidylinositol-anchored alkaline phosphatase of calf intestine.
European journal of biochemistry / FEBS 1993;217(1):199-207.
1993: Diederik Gommers; C Vilstrup; J A Bos; Anders Larsson; Olof Werner; Ewald Hannappel; Burkhard Lachmann
Exogenous surfactant therapy increases static lung compliance, and cannot be assessed by measurements of dynamic compliance alone.
Critical care medicine 1993;21(4):567-74.
1993: Ewald Hannappel; F Wartenberg
Actin-sequestering ability of thymosin beta 4, thymosin beta 4 fragments, and thymosin beta 4-like peptides as assessed by the DNase I inhibition assay.
Biological chemistry Hoppe-Seyler 1993;374(2):117-22.
1993: Michael Küchle; Ewald Hannappel; Nhung X Nguyen; S T Ho; W Beck; Gottfried Naumann
[Correlation between tyndallometry with the "laser flare cell meter" in vivo and biochemical protein determination in human aqueous humor].
Klinische Monatsblätter für Augenheilkunde 1993;202(1):14-8.
1992: T Voss; Klaus P Schäfer; P F Nielsen; A Schäfer; C Maier; Ewald Hannappel; J Maassen; B Landis; K Klemm; Michael Przybylski
Primary structure differences of human surfactant-associated proteins isolated from normal and proteinosis lung.
Biochimica et biophysica acta 1992;1138(4):261-7.
1992: J A Bos; P Wollmer; W Bakker; Ewald Hannappel; Burkhard Lachmann
Clearance of 99mTc-DTPA and experimentally increased alveolar surfactant content.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(4):1413-7.
1992: G J Van Daal; J A Bos; E P Eijking; Diederik Gommers; Ewald Hannappel; Burkhard Lachmann
Surfactant replacement therapy improves pulmonary mechanics in end-stage influenza A pneumonia in mice.
The American review of respiratory disease 1992;145(4 Pt 1):859-63.
1992: E P Eijking; G J van Daal; R Tenbrinck; J F Sluiters; Ewald Hannappel; Wilhelm Erdmann; Burkhard Lachmann
Improvement of pulmonary gas exchange after surfactant replacement in rats with Pneumocystis carinii pneumonia.
Advances in experimental medicine and biology 1992;316():293-8.
1991: B Schöbitz; Ewald Hannappel; KA Brand
The early induction of the actin-sequestering peptide thymosin beta 4 in thymocytes depends on the proliferative stimulus.
Biochimica et biophysica acta 1991;1095(3):230-5.
1991: E P Eijking; D S Strayer; G J van Daal; R Tenbrinck; T A Merritt; Ewald Hannappel; Burkhard Lachmann
In vivo and in vitro inactivation of bovine surfactant by an anti-surfactant monoclonal antibody.
The European respiratory journal 1991;4(10):1245-50.
1991: B Schöbitz; R Netzker; Ewald Hannappel; KA Brand
Cell-cycle-regulated expression of thymosin beta 4 in thymocytes.
European journal of biochemistry / FEBS 1991;199(2):257-62.
1991: E P Eijking; G J van Daal; R Tenbrinck; A Luijendijk; J F Sluiters; Ewald Hannappel; Burkhard Lachmann
Effect of surfactant replacement on Pneumocystis carinii pneumonia in rats.
Intensive care medicine 1991;17(8):475-8.
1990: C Grillon; K Rieger; J Bakala; D Schott; J L Morgat; Ewald Hannappel; W Voelter; M Lenfant
Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system.
FEBS letters 1990;274(1-2):30-4.
1990: B Schöbitz; R Netzker; Ewald Hannappel; KA Brand
Rapid induction of thymosin beta 4 in concanavalin A-stimulated thymocytes by translational control.
The Journal of biological chemistry 1990;265(26):15387-91.
1990: J Zarbock; Hartmut Oschkinat; Ewald Hannappel; Hubert Kalbacher; Wolfgang Voelter; Tad A Holak
Solution conformation of thymosin beta 4: a nuclear magnetic resonance and simulated annealing study.
Biochemistry 1990;29(34):7814-21.
1990: M Mihelić; W Giebel; N R Wei; Ewald Hannappel; Hubert Kalbacher; Wolfgang Voelter
Immunohistochemical localization of thymosin beta 9 in bovine tissues.
Histochemistry 1990;95(2):175-8.
1989: Ewald Hannappel; F Wartenberg; X R Bustelo
Isolation and characterization of thymosin beta 9 Met from pork spleen.
Archives of biochemistry and biophysics 1989;273(2):396-402.
1989: M Mihelić; Hubert Kalbacher; Ewald Hannappel; Wolfgang Voelter
MicroELISA method for the determination of thymosin beta 9 discriminating between thymosin beta 9 and the structurally closely related thymosin beta 4.
Journal of immunological methods 1989;122(1):7-13.
1989: A A Haritos; P P Yialouris; E P Heimer; A M Felix; Ewald Hannappel; M A Rosemeyer
Evidence for the monomeric nature of thymosins.
FEBS letters 1989;244(2):287-90.
1988: O E Tsitsiloni; P P Yialouris; E P Heimer; A M Felix; G P Evangelatos; C Soteriadis-Vlahos; J Stiakakis; Ewald Hannappel; A A Haritos
A radioimmunoassay for parathymosin alpha using antibodies to synthetic N-terminal peptide 1-30.
Journal of immunological methods 1988;113(2):175-84.
1988: Ewald Hannappel; Hubert Kalbacher; Wolfgang Voelter
Thymosin beta 4Xen: a new thymosin beta 4-like peptide in oocytes of Xenopus laevis.
Archives of biochemistry and biophysics 1988;260(2):546-51.
1987: Ewald Hannappel; M van Kampen
Determination of thymosin beta 4 in human blood cells and serum.
Journal of chromatography 1987;397():279-85.
1986: Ewald Hannappel
One-step procedure for the determination of thymosin beta 4 in small tissue samples and its separation from other thymosin beta 4-like peptides by high-pressure liquid chromatography.
Analytical biochemistry 1986;156(2):390-6.
1985: Ewald Hannappel; W Leibold
Biosynthesis rates and content of thymosin beta 4 in cell lines.
Archives of biochemistry and biophysics 1985;240(1):236-41.
1985: B L Horecker; S Erickson-Viitanen; Ewald Hannappel
Thymosin beta 4-like peptides.
Methods in enzymology 1985;116():265-9.
1985: Ewald Hannappel; G Pankow; F Grassl; K Brand; Gottfried Naumann
Amino acid pattern in human aqueous humor of patients with senile cataract and primary open-angle glaucoma.
Ophthalmic research 1985;17(6):341-3.
1982: J S MacGregor; Ewald Hannappel; G J Xu; S Pontremoli; B L Horecker
Conservation of primary structure at the proteinase-sensitive site of fructose 1,6-bisphosphatases.
Archives of biochemistry and biophysics 1982;217(2):652-64.
1982: G J Xu; Ewald Hannappel; J Morgan; J Hempstead; B L Horecker
Synthesis of thymosin beta 4 by peritoneal macrophages and adherent spleen cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(13):4006-9.
1982: Ewald Hannappel; G J Xu; J Morgan; J Hempstead; B L Horecker
Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2172-5.
1982: Ewald Hannappel; J S MacGregor; S Davoust; B L Horecker
Limited proteolysis of liver and muscle aldolases: effects of subtilisin, cathepsin B, and Staphylococcus aureus protease.
Archives of biochemistry and biophysics 1982;214(1):293-8.
1982: Ewald Hannappel; S Davoust; B L Horecker
Thymosins beta 8 and beta 9: two new peptides isolated from calf thymus homologous to thymosin beta 4.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(6):1708-11.
1982: Ewald Hannappel; S Davoust; B L Horecker
Isolation of peptides from calf thymus.
Biochemical and biophysical research communications 1982;104(1):266-71.
1981: H Kido; A Vita; Ewald Hannappel; B L Horecker
Aminoterminal acetylation of synthetic N alpha-desacetyl thymosin alpha 1.
Archives of biochemistry and biophysics 1981;208(1):95-100.
1981: S C Sun; A G Datta; Ewald Hannappel; V N Singh; O Tsolas; E Melloni; S Pontremoli; B L Horecker
The carboxy-terminal amino acid sequence of rabbit liver fructose 1,6-bisphosphatase.
Archives of biochemistry and biophysics 1981;206(2):265-70.
1981: Ewald Hannappel; U Drews
Stimulation of growth by testosterone via the mesenchyme. Recombination of tissues from Tfm and wild-type preputial gland anlagen of mouse embryo.
Cell and tissue research 1981;221(2):321-32.
1981: M Freire; Ewald Hannappel; M Rey; J M Freire; H Kido; B L Horecker
Purification of thymus mRNA coding for a 16,000-dalton polypeptide containing the thymosin alpha 1 sequence.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(1):192-5.
1980: W Weigand; Ewald Hannappel; K Brand
Effect of starvation and refeeding a high-protein or high-carbohydrate diet on lipid composition and glycogen content of rat livers in relation to age.
The Journal of nutrition 1980;110(4):669-74.
1980: Ewald Hannappel; W Siegler; U Drews
Demonstration of 2n spermatids in carriers of the "sex reversed" factor in the mouse by Feulgen cytophotometry.
Histochemistry 1980;69(3):299-306.
1979: Ewald Hannappel; U Drews
Mosaic character of spermatogenesis in carriers of the sex reversed factor in the mouse.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1979;11(12):682-9.
1978: G Sturm; Ewald Hannappel
Intra-ovarian formation of steroid sulphates: measurement and influence of gonadotrophins.
The Journal of endocrinology 1978;79(3):291-9.