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Gregory Hannon

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RNA Interference

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Camila O Dos Santos; Elena Y Harris; Lolahon R Kadiri; Pavel Osten; Clare Rebbeck; Elena Rozhkova; Abigail Samuels; Andrew D Smith; Philip J Uren; Amy Valentine; Gregory J Hannon
Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.
Leah R Sabin; M Joaquina Delás; Gregory J Hannon
Dogma derailed: the many influences of RNA on the genome.
Paloma M Guzzardo; Felix Muerdter; Gregory J Hannon
The piRNA pathway in flies: highlights and future directions.

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2013: Camila O Dos Santos; Elena Y Harris; Lolahon R Kadiri; Pavel Osten; Clare Rebbeck; Elena Rozhkova; Abigail Samuels; Andrew D Smith; Philip J Uren; Amy Valentine; Gregory J Hannon
Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7123-30.
2013: Leah R Sabin; M Joaquina Delás; Gregory J Hannon
Dogma derailed: the many influences of RNA on the genome.
Molecular cell 2013;49(5):783-94.
2013: Paloma M Guzzardo; Felix Muerdter; Gregory J Hannon
The piRNA pathway in flies: highlights and future directions.
Current opinion in genetics & development 2013;23(1):44-52.
2013: Leah R Sabin; Pramod Thekkat; Matthew Tudor; Jamie Yang; Qi Zheng; Brian D Gregory; Gregory J Hannon; Sara Cherry
Dicer-2 processes diverse viral RNA species.
PloS one 2013;8(2):e55458.
2012: Philip J Uren; Emad Bahrami-Samani; Suzanne C Burns; Gregory J Hannon; Emily Hodges; Fedor V Karginov; Luiz Penalva; Mei Qiao; Jeremy R Sanford; Andrew D Smith
Site identification in high-throughput RNA-protein interaction data.
Bioinformatics (Oxford, England) 2012;28(23):3013-20.
2012: Elad Elkayam; Emily M Greene; Astrid D Haase; Gregory J Hannon; Claus-D Kuhn; Ante Tocilj; Leemor Joshua-Tor
The structure of human argonaute-2 in complex with miR-20a.
Cell 2012;150(1):100-10.
2012: Fang Fang; Gregory J Hannon; Emily Hodges; Antoine Molaro; Matthew Dean; Andrew D Smith
Genomic landscape of human allele-specific DNA methylation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7332-7.
2012: Lukas E Dow; Christof Fellmann; Gregory J Hannon; Katherine McJunkin; Cornelius Miething; Youngkyu Park; Prem K Premsrirut; Johannes Zuber; Ross A Dickins; Scott W Lowe
A pipeline for the generation of shRNA transgenic mice.
Nature protocols 2012;7(2):374-93.
2012: Miao He; Yu Liu; Xiaowo Wang; Michael Q Zhang; Gregory J Hannon; Z Josh Huang
Cell-type-based analysis of microRNA profiles in the mouse brain.
Neuron 2012;73(1):35-48.
2012: Hannah S Bender; Carly Conlan; Janine Deakin; Carol W Greider; Gregory J Hannon; Daniel A McMillan; Elizabeth P Murchison; Axel Neumann; Hilda A Pickett; Roger R Reddel; Margaret A Strong; Jennifer A Marshall Graves
Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.
PloS one 2012;7(9):e46195.
2011: Emily Hodges; W Richard McCombie; Antoine Molaro; Jin Park; Shahin Rafii; Andrew D Smith; Qiang Song; Pramod Thekkat; Philip J Uren; Jason Butler; Camila O Dos Santos; Gregory J Hannon
Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.
Molecular cell 2011;44(1):17-28.
2011: Leemor Joshua-Tor; Gregory J Hannon
Ancestral roles of small RNAs: an Ago-centric perspective.
Cold Spring Harbor perspectives in biology 2011;3(10):a003772.
2011: Antoine Molaro; Qiang Song; Fang Fang; Gregory J Hannon; Emily Hodges; W Richard McCombie; Andrew D Smith
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates.
Cell 2011;146(6):1029-41.
2011: Andrea L Zamparini; Jiri Zavadil; Marie Y Davis; Gregory J Hannon; Colin D Malone; Ravi Sachidanandam; Eric Vieira; Ruth Lehmann
Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.
Development (Cambridge, England) 2011;138(18):4039-50.
2011: Prashanth Rangan; Ravi Sachidanandam; Gregory J Hannon; Patrick S Hayes; Colin D Malone; Caryn Navarro; Sam P Newbold; Ruth Lehmann
piRNA production requires heterochromatin formation in Drosophila.
Current biology : CB 2011;21(16):1373-9.
2011: Prem K Premsrirut; Lukas E Dow; Sang Yong Kim; Matthew Camiolo; Colin D Malone; Cornelius Miething; Claudio Scuoppo; Johannes Zuber; Ross A Dickins; Scott C Kogan; Kenneth R Shroyer; Raffaella Sordella; Gregory J Hannon; Scott W Lowe
A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Cell 2011;145(1):145-58.
2011: Christof Fellmann; Johannes Zuber; Katherine McJunkin; Kenneth Chang; Colin D Malone; Ross A Dickins; Qikai Xu; Michael O Hengartner; Stephen J Elledge; Gregory J Hannon; Scott W Lowe
Functional identification of optimized RNAi triggers using a massively parallel sensor assay.
Molecular cell 2011;41(6):733-46.
2011: Johannes Zuber; Katherine McJunkin; Christof Fellmann; Lukas E Dow; Meredith J Taylor; Gregory J Hannon; Scott W Lowe
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.
Nature biotechnology 2011;29(1):79-83.
2011: Benjamin Czech; Gregory J Hannon
Small RNA sorting: matchmaking for Argonautes.
Nature reviews. Genetics 2011;12(1):19-31.
2010: Astrid D Haase; Silvia Fenoglio; Felix Muerdter; Paloma M Guzzardo; Benjamin Czech; Darryl J Pappin; Caifu Chen; Assaf Gordon; Gregory J Hannon
Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.
Genes & development 2010;24(22):2499-504.
2010: Mark M W Chong; Guoan Zhang; Sihem Cheloufi; Thomas A Neubert; Gregory J Hannon; Dan R Littman
Canonical and alternate functions of the microRNA biogenesis machinery.
Genes & development 2010;24(17):1951-60.
2010: Fedor V Karginov; Sihem Cheloufi; Mark M W Chong; Alexander Stark; Andrew D Smith; Gregory J Hannon
Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.
Molecular cell 2010;38(6):781-8.
2010: Fedor V Karginov; Gregory J Hannon
The CRISPR system: small RNA-guided defense in bacteria and archaea.
Molecular cell 2010;37(1):7-19.
2010: Elizabeth P Murchison; Cesar Tovar; Arthur Hsu; Hannah S Bender; Pouya Kheradpour; Clare A Rebbeck; David Obendorf; Carly Conlan; Melanie Bahlo; Catherine A Blizzard; Stephen Pyecroft; Alexandre Kreiss; Manolis Kellis; Alexander Stark; Timothy T Harkins; Jennifer A Marshall Graves; Gregory M Woods; Gregory J Hannon; Anthony T Papenfuss
The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.
Science (New York, N.Y.) 2010;327(5961):84-7.
2009: Alexei A Aravin; Godfried W van der Heijden; Julio Castañeda; Vasily V Vagin; Gregory J Hannon; Alex Bortvin
Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.
PLoS genetics 2009;5(12):e1000764.
2009: Benjamin Czech; Rui Zhou; Yaniv Erlich; Julius Brennecke; Richard Binari; Christians Villalta; Assaf Gordon; Norbert Perrimon; Gregory J Hannon
Hierarchical rules for Argonaute loading in Drosophila.
Molecular cell 2009;36(3):445-56.
2009: Andrew D Smith; Wen-Yu Chung; Emily Hodges; Jude Kendall; Gregory J Hannon; James Hicks; Zhenyu Xuan; Michael Q Zhang
Updates to the RMAP short-read mapping software.
Bioinformatics (Oxford, England) 2009;25(21):2841-2.
2009: Anka Bric; Cornelius Miething; Carl Uli Bialucha; Claudio Scuoppo; Lars Zender; Alexander Krasnitz; Zhenyu Xuan; Johannes Zuber; Michael Wigler; James Hicks; RW McCombie; Michael T Hemann; Gregory J Hannon; Scott Powers; Scott W Lowe
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Cancer cell 2009;16(4):324-35.
2009: Emily Hodges; Andrew D Smith; Jude Kendall; Zhenyu Xuan; Kandasamy Ravi; Michelle Rooks; Michael Q Zhang; Qian Ye; Arindam Bhattacharjee; leonardo brizuela; W Richard McCombie; Michael Wigler; Gregory J Hannon; James B Hicks
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.
Genome research 2009;19(9):1593-605.
2009: Oded Rechavi; Yaniv Erlich; Hila Amram; Lena Flomenblit; Fedor V Karginov; Itamar Goldstein; Gregory J Hannon; Yoel Kloog
Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs.
Genes & development 2009;23(16):1971-9.
2009: Vasily V Vagin; James Wohlschlegel; jun qu; Zophonias Jonsson; Xinhua Huang; Shinichiro Chuma; Angelique Girard; Ravi Sachidanandam; Gregory J Hannon; Alexei A Aravin
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.
Genes & development 2009;23(15):1749-62.
2009: Yaniv Erlich; Kenneth Chang; Assaf Gordon; Roy Ronen; Oron Navon; Michelle Rooks; Gregory J Hannon
DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysis.
Genome research 2009;19(7):1243-53.
2009: Jose M Silva; Elena Ezhkova; Javier Silva; Stephen Heart; Mireia Castillo; Yolanda Campos; Veronica Castro; Felix Bonilla; Carlos Cordon-Cardo; Senthil K Muthuswamy; Scott Powers; Elaine Fuchs; Gregory J Hannon
Cyfip1 is a putative invasion suppressor in epithelial cancers.
Cell 2009;137(6):1047-61.
2009: Colin D Malone; Julius Brennecke; Monica Dus; Alexander Stark; W Richard McCombie; Ravi Sachidanandam; Gregory J Hannon
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.
Cell 2009;137(3):522-35.
2009: Colin D Malone; Gregory J Hannon
Small RNAs as guardians of the genome.
Cell 2009;136(4):656-68.
2009: C D Malone; Gregory J Hannon
Molecular evolution of piRNA and transposon control pathways in Drosophila.
Cold Spring Harbor symposia on quantitative biology 2009;74():225-34.
2008: Julius Brennecke; Colin D Malone; Alexei A Aravin; Ravi Sachidanandam; Alexander Stark; Gregory J Hannon
An epigenetic role for maternally inherited piRNAs in transposon silencing.
Science (New York, N.Y.) 2008;322(5906):1387-92.
2008: Lars Zender; Wen Xue; Johannes Zuber; Camile P Semighini; Alexander Krasnitz; Beicong Ma; Peggy Zender; Stefan Kubicka; John Luk; Peter Schirmacher; W Richard McCombie; Michael Wigler; James Hicks; Gregory J Hannon; Scott Powers; Scott W Lowe
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.
Cell 2008;135(5):852-64.
2008: Rui Zhou; Ikuko Hotta; Ahmet M Denli; Pengyu Hong; Norbert Perrimon; Gregory J Hannon
Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.
Molecular cell 2008;32(4):592-9.
2008: Alexei A Aravin; Ravi Sachidanandam; Déborah Bourc'his; Christopher Schaefer; Dubravka Pezic; Katalin Fejes Toth; Timothy H Bestor; Gregory J Hannon
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.
Molecular cell 2008;31(6):785-99.
2008: Darren J Burgess; Jason Doles; Lars Zender; Wen Xue; Beicong Ma; W Richard McCombie; Gregory J Hannon; Scott W Lowe; Michael T Hemann
Topoisomerase levels determine chemotherapy response in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9053-8.
2008: Benjamin Czech; Colin D Malone; Rui Zhou; Alexander Stark; Catherine Schlingeheyde; Monica Dus; Norbert Perrimon; Manolis Kellis; James Wohlschlegel; Ravi Sachidanandam; Gregory J Hannon; Julius Brennecke
An endogenous small interfering RNA pathway in Drosophila.
Nature 2008;453(7196):798-802.
2008: Elizabeth P Murchison; Pouya Kheradpour; Ravi Sachidanandam; Carly Smith; Emily Hodges; Zhenyu Xuan; Manolis Kellis; Frank Grützner; Alexander Stark; Gregory J Hannon
Conservation of small RNA pathways in platypus.
Genome research 2008;18(6):995-1004.
2008: Jian Du; Sandra Jablonski; Tim J Yen; Gregory J Hannon
Astrin regulates Aurora-A localization.
Biochemical and biophysical research communications 2008;370(2):213-9.
2008: Oliver H Tam; Alexei A Aravin; Paula Stein; Angélique Girard; Elizabeth P Murchison; Sihem Cheloufi; Emily Hodges; Martin Anger; Ravi Sachidanandam; Richard M Schultz; Gregory J Hannon
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.
Nature 2008;453(7194):534-8.
2008: Kathryn A Tworkowski; Abhishek A Chakraborty; Andrew V Samuelson; Yvette R Seger; Masako Narita; Gregory J Hannon; Scott W Lowe; William P Tansey
Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6103-8.
2008: Roberta Benetti; Susana Gonzalo; Isabel Jaco; Purificación Muñoz; Susana Gonzalez; Stefan Schoeftner; Elizabeth Murchison; Thomas Andl; Taiping Chen; Peter Klatt; En Li; Manuel Serrano; Sarah Millar; Gregory J Hannon; María A Blasco
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.
Nature structural & molecular biology 2008;15(3):268-79.
2008: Angélique Girard; Gregory J Hannon
Conserved themes in small-RNA-mediated transposon control.
Trends in cell biology 2008;18(3):136-48.
2008: Jian-Fu Chen; Elizabeth P Murchison; Ruhang Tang; Thomas E Callis; Mariko Tatsuguchi; Zhongliang Deng; Mauricio Rojas; Scott M Hammond; Michael D Schneider; Craig H Selzman; Gerhard Meissner; Winston Patterson; Gregory J Hannon; Dazhi Wang
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2111-6.
2008: Michael R Schlabach; Ji Luo; Nicole L Solimini; Guang Hu; Qikai Xu; Mamie Z Li; Zhenming Zhao; Agata Smogorzewska; Mathew E Sowa; Xiaolu L Ang; Thomas F Westbrook; Anthony C Liang; Kenneth Chang; Jennifer A Hackett; J Wade Harper; Gregory J Hannon; Stephen J Elledge
Cancer proliferation gene discovery through functional genomics.
Science (New York, N.Y.) 2008;319(5863):620-4.
2008: Jose M Silva; Krista Marran; Joel Parker; Javier Silva; Michael Golding; Michael R Schlabach; Stephen J Elledge; Gregory J Hannon; Kenneth Chang
Profiling essential genes in human mammary cells by multiplex RNAi screening.
Science (New York, N.Y.) 2008;319(5863):617-20.
2008: Henry J Haiser; Fedor V Karginov; Gregory J Hannon; Marie A Elliot
Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.
Nucleic acids research 2008;36(3):732-41.
2008: Alexei A Aravin; Gregory J Hannon
Small RNA silencing pathways in germ and stem cells.
Cold Spring Harbor symposia on quantitative biology 2008;73():283-90.
2008: A J Olson; Julius Brennecke; Alexei A Aravin; Gregory J Hannon; Ravi Sachidanandam
Analysis of large-scale sequencing of small RNAs.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2008;():126-36.
2008: David M Tyler; Katsutomo Okamura; Wei-Jen Chung; Joshua W Hagen; Eugene Berezikov; Gregory J Hannon; Eric C Lai
Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.
Genes & development 2008;22(1):26-36.
2007: Ingrid Ibarra; Yaniv Erlich; Senthil K Muthuswamy; Ravi Sachidanandam; Gregory J Hannon
A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.
Genes & development 2007;21(24):3238-43.
2007: Fedor V Karginov; Cecilia Conaco; Zhenyu Xuan; Bryan H Schmidt; Joel Parker; Gail Mandel; Gregory J Hannon
A biochemical approach to identifying microRNA targets.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19291-6.
2007: Xingyue He; Lin He; Gregory J Hannon
The guardian's little helper: microRNAs in the p53 tumor suppressor network.
Cancer research 2007;67(23):11099-101.
2007: Alexander Stark; Pouya Kheradpour; Leopold Parts; Julius Brennecke; Emily Hodges; Gregory J Hannon; Manolis Kellis
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.
Genome research 2007;17(12):1865-79.
2007: Emily Hodges; Zhenyu Xuan; Vivekanand Balija; Melissa Kramer; Michael Molla; Steven W Smith; Christina M Middle; Matthew J Rodesch; Thomas J Albert; Gregory J Hannon; W Richard McCombie
Genome-wide in situ exon capture for selective resequencing.
Nature genetics 2007;39(12):1522-7.
2007: Alexei A Aravin; Gregory J Hannon; Julius Brennecke
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.
Science (New York, N.Y.) 2007;318(5851):761-4.
2007: Lin He; Xingyue He; Scott W Lowe; Gregory J Hannon
microRNAs join the p53 network--another piece in the tumour-suppression puzzle.
Nature reviews. Cancer 2007;7(11):819-22.
2007: Ross A Dickins; Katherine McJunkin; Eva Hernando; Prem K Premsrirut; Valery Krizhanovsky; Darren J Burgess; Sang Yong Kim; Carlos Cordon-Cardo; Lars Zender; Gregory J Hannon; Scott W Lowe
Tissue-specific and reversible RNA interference in transgenic mice.
Nature genetics 2007;39(7):914-21.
2007: Lin He; Xingyue He; Lee P Lim; Elisa de Stanchina; Zhenyu Xuan; Yu Liang; Wen Xue; Lars Zender; Jill Magnus; Dana Ridzon; Aimee L Jackson; Peter Linsley; Caifu Chen; Scott W Lowe; Michele A Cleary; Gregory J Hannon
A microRNA component of the p53 tumour suppressor network.
Nature 2007;447(7148):1130-4.
2007: Alexei A Aravin; Ravi Sachidanandam; Angélique Girard; Katalin Fejes-Toth; Gregory J Hannon
Developmentally regulated piRNA clusters implicate MILI in transposon control.
Science (New York, N.Y.) 2007;316(5825):744-7.
2007: Viji M Draviam; Frank Stegmeier; Grzegorz Nalepa; Mathew E Sowa; Jing Chen; Anthony Liang; Gregory J Hannon; Peter K Sorger; J Wade Harper; Stephen J Elledge
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Nature cell biology 2007;9(5):556-64.
2007: Frank Stegmeier; Michael Rape; Viji M Draviam; Grzegorz Nalepa; Mathew E Sowa; Xiaolu L Ang; E Robert McDonald; Mamie Z Li; Gregory J Hannon; Peter K Sorger; Marc W Kirschner; J Wade Harper; Stephen J Elledge
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
Nature 2007;446(7138):876-81.
2007: Saskia Houwing; Leonie Marjan Kamminga; Eugene Berezikov; Daniela Cronembold; Angélique Girard; Hans van den Elst; Dmitri V Filippov; Heiko Blaser; erez raz; Cecilia B Moens; Ronald H Plasterk; Gregory J Hannon; Bruce W Draper; René F Ketting
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.
Cell 2007;129(1):69-82.
2007: Michelle A Carmell; Angélique Girard; Henk J G van de Kant; Déborah Bourc'his; Timothy H Bestor; Dirk G de Rooij; Gregory J Hannon
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.
Developmental cell 2007;12(4):503-14.
2007: Julius Brennecke; Alexei A Aravin; Alexander Stark; Monica Dus; Manolis Kellis; Ravi Sachidanandam; Gregory J Hannon
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.
Cell 2007;128(6):1089-103.
2007: Elizabeth P Murchison; Paula Stein; Zhenyu Xuan; Hua Pan; Michael Q Zhang; Richard M Schultz; Gregory J Hannon
Critical roles for Dicer in the female germline.
Genes & development 2007;21(6):682-93.
2007: Angélique Girard; Gregory J Hannon
[The role of piRNAs in mouse spermatogenesis.].
Journal de la Société de biologie 2007;201(4):411-8.
2006: Yijun Qi; Xingyue He; Xiu-Jie Wang; Oleksiy Kohany; Jerzy Jurka; Gregory J Hannon
Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation.
Nature 2006;443(7114):1008-12.
2006: Kenneth Chang; Stephen J Elledge; Gregory J Hannon
Lessons from Nature: microRNA-based shRNA libraries.
Nature methods 2006;3(9):707-14.
2006: Angélique Girard; Ravi Sachidanandam; Gregory J Hannon; Michelle A Carmell
A germline-specific class of small RNAs binds mammalian Piwi proteins.
Nature 2006;442(7099):199-202.
2006: Lars Zender; Mona S Spector; Wen Xue; Peer Flemming; Carlos Cordon-Cardo; John Silke; Sheung-Tat Fan; John Luk; Michael Wigler; Gregory J Hannon; David Mu; Robert Lucito; Scott Powers; Scott W Lowe
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.
Cell 2006;125(7):1253-67.
2006: Thomas Andl; Elizabeth P Murchison; Fei Liu; Yuhang Zhang; Monica Yunta-Gonzalez; John W Tobias; Claudia D Andl; John T Seykora; Gregory J Hannon; Sarah E Millar
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles.
Current biology : CB 2006;16(10):1041-9.
2006: Michael C Golding; Charles R Long; Michelle A Carmell; Gregory J Hannon; Mark E Westhusin
Suppression of prion protein in livestock by RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5285-90.
2006: Marco Antonio Valencia-Sanchez; Jidong Liu; Gregory J Hannon; Roy Parker
Control of translation and mRNA degradation by miRNAs and siRNAs.
Genes & development 2006;20(5):515-24.
2006: Douglas X Mason; Daniel Keppler; Jun Zhang; Tonya J Jackson; Yvette R Seger; Seiichi Matsui; Fleurette Abreo; John Kenneth Cowell; Gregory J Hannon; Scott W Lowe; Athena W Lin
Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts.
Carcinogenesis 2006;27(2):350-9.
2006: Gregory J Hannon; Fabiola V Rivas; Elizabeth P Murchison; J A Steitz
The expanding universe of noncoding RNAs.
Cold Spring Harbor symposia on quantitative biology 2006;71():551-64.
2006: A Olson; Nihar Sheth; J S Lee; Gregory J Hannon; Ravi Sachidanandam
RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs.
Nucleic acids research 2006;34(Database issue):D153-7.
2005: Jidong Liu; Fabiola V Rivas; James Wohlschlegel; John R Yates; Roy Parker; Gregory J Hannon
A role for the P-body component GW182 in microRNA function.
Nature cell biology 2005;7(12):1261-6.
2005: Jose M Silva; Mamie Z Li; Kenneth Chang; Wei Ge; Michael C Golding; Richard J Rickles; Despina Siolas; Guang Hu; Patrick J Paddison; Michael R Schlabach; Nihar Sheth; Jeff Bradshaw; Julja Burchard; Amit Kulkarni; Guy Cavet; Ravi Sachidanandam; W Richard McCombie; Michele A Cleary; Stephen J Elledge; Gregory J Hannon
Second-generation shRNA libraries covering the mouse and human genomes.
Nature genetics 2005;37(11):1281-8.
2005: Ross A Dickins; Michael T Hemann; Jack T Zilfou; David R Simpson; Ingrid Ibarra; Gregory J Hannon; Scott W Lowe
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors.
Nature genetics 2005;37(11):1289-95.
2005: Yijun Qi; Gregory J Hannon
Uncovering RNAi mechanisms in plants: biochemistry enters the foray.
FEBS letters 2005;579(26):5899-903.
2005: Vera Schramke; Daniel M Sheedy; Ahmet M Denli; Carolina Bonila; Karl Ekwall; Gregory J Hannon; Robin C Allshire
Retraction: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription.
Nature 2005;437(7061):1057.
2005: Frank Stegmeier; Guang Hu; Richard J Rickles; Gregory J Hannon; Stephen J Elledge
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13212-7.
2005: Elizabeth P Murchison; Janet F Partridge; Oliver H Tam; Sihem Cheloufi; Gregory J Hannon
Characterization of Dicer-deficient murine embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12135-40.
2005: Yijun Qi; Ahmet M Denli; Gregory J Hannon
Biochemical specialization within Arabidopsis RNA silencing pathways.
Molecular cell 2005;19(3):421-8.
2005: Jidong Liu; Marco Antonio Valencia-Sanchez; Gregory J Hannon; Roy Parker
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.
Nature cell biology 2005;7(7):719-23.
2005: Vera Schramke; Daniel M Sheedy; Ahmet M Denli; Carolina Bonila; Karl Ekwall; Gregory J Hannon; Robin C Allshire
RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription.
Nature 2005;435(7046):1275-9.
2005: Thomas F Westbrook; Eric S Martin; Michael R Schlabach; Yumei Leng; Anthony C Liang; Bin Feng; Jean J Zhao; Thomas M Roberts; Gail Mandel; Gregory J Hannon; Ronald A DePinho; Lynda Chin; Stephen J Elledge
A genetic screen for candidate tumor suppressors identifies REST.
Cell 2005;121(6):837-48.
2005: Lin He; J Michael Thomson; Michael T Hemann; Eva Hernando-Monge; David Mu; Summer Goodson; Scott Powers; Carlos Cordon-Cardo; Scott W Lowe; Gregory J Hannon; Scott M Hammond
A microRNA polycistron as a potential human oncogene.
Nature 2005;435(7043):828-33.
2005: Fabiola V Rivas; Niraj H Tolia; Ji-Joon Song; Juan P Aragon; Jidong Liu; Gregory J Hannon; Leemor Joshua-Tor
Purified Argonaute2 and an siRNA form recombinant human RISC.
Nature structural & molecular biology 2005;12(4):340-9.
2005: Despina Siolas; Cara Lerner; Julja Burchard; Wei Ge; Peter Linsley; Patrick J Paddison; Gregory J Hannon; Michele A Cleary
Synthetic shRNAs as potent RNAi triggers.
Nature biotechnology 2005;23(2):227-31.
2005: Lars Zender; Wen Xue; Carlos Cordón-Cardo; Gregory J Hannon; Robert Lucito; Scott Powers; P Flemming; Mona S Spector; Scott W Lowe
Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors.
Cold Spring Harbor symposia on quantitative biology 2005;70():251-61.
2004: Michele A Cleary; Kristopher Kilian; Yanqun Wang; Jeff Bradshaw; Guy Cavet; Wei Ge; Amit Kulkarni; Patrick J Paddison; Kenneth Chang; Nihar Sheth; Eric Leproust; Ernest M Coffey; Julja Burchard; W Richard McCombie; Peter Linsley; Gregory J Hannon
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis.
Nature methods 2004;1(3):241-8.
2004: Sujit Dike; Vivekanand Balija; Lidia U Nascimento; Zhenyu Xuan; Jacqueline Ou; Theresa Zutavern; Lance E Palmer; Gregory J Hannon; Michael Q Zhang; W Richard McCombie
The mouse genome: experimental examination of gene predictions and transcriptional start sites.
Genome research 2004;14(12):2424-9.
2004: Ahmet M Denli; Bastiaan B J Tops; Ronald H Plasterk; René F Ketting; Gregory J Hannon
Processing of primary microRNAs by the Microprocessor complex.
Nature 2004;432(7014):231-5.
2004: Patrick J Paddison; Michele Cleary; Jose Maria Silva; Kenneth Chang; Nihar Sheth; Ravi Sachidanandam; Gregory J Hannon
Cloning of short hairpin RNAs for gene knockdown in mammalian cells.
Nature methods 2004;1(2):163-7.
2004: Jose Silva; Kenneth Chang; Gregory J Hannon; Fabiola V Rivas
RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age.
Oncogene 2004;23(51):8401-9.
2004: Gregory J Hannon; John J Rossi
Unlocking the potential of the human genome with RNA interference.
Nature 2004;431(7006):371-8.
2004: Jidong Liu; Michelle A Carmell; Fabiola V Rivas; Carolyn G Marsden; J Michael Thomson; Ji-Joon Song; Scott M Hammond; Leemor Joshua-Tor; Gregory J Hannon
Argonaute2 is the catalytic engine of mammalian RNAi.
Science (New York, N.Y.) 2004;305(5689):1437-41.
2004: Lin He; Gregory J Hannon
MicroRNAs: small RNAs with a big role in gene regulation.
Nature reviews. Genetics 2004;5(7):522-31.
2004: Michael T Hemann; Jack T Zilfou; Zhen Zhao; Darren J Burgess; Gregory J Hannon; Scott W Lowe
Suppression of tumorigenesis by the p53 target PUMA.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9333-8.
2004: Jian Du; Gregory J Hannon
Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):8975-80.
2004: Elizabeth P Murchison; Gregory J Hannon
miRNAs on the move: miRNA biogenesis and the RNAi machinery.
Current opinion in cell biology 2004;16(3):223-9.
2004: Petr Svoboda; Paula Stein; Martin Anger; Emily Bernstein; Gregory J Hannon; Richard M Schultz
RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos.
Developmental biology 2004;269(1):276-85.
2004: Jose M Silva; Hana Mizuno; Amy Brady; Robert Lucito; Gregory J Hannon
RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6548-52.
2004: Patrick J Paddison; Jose M Silva; Douglas S Conklin; Michael R Schlabach; Mamie Li; Shola Aruleba; Vivekanand Balija; Andrew O'Shaughnessy; Lidia Gnoj; Kim Scobie; Kenneth Chang; Thomas Westbrook; Michele Cleary; Ravi Sachidanandam; W Richard McCombie; Stephen J Elledge; Gregory J Hannon
A resource for large-scale RNA-interference-based screens in mammals.
Nature 2004;428(6981):427-31.
2004: Michelle A Carmell; Gregory J Hannon
RNase III enzymes and the initiation of gene silencing.
Nature structural & molecular biology 2004;11(3):214-8.
2004: Patrick J Paddison; Amy A Caudy; Ravi Sachidanandam; Gregory J Hannon
Short hairpin activated gene silencing in mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2004;265():85-100.
2004: Amy A Caudy; Gregory J Hannon
Induction and biochemical purification of RNA-induced silencing complex from Drosophila S2 cells.
Methods in molecular biology (Clifton, N.J.) 2004;265():59-72.
2004: Gregory J Hannon; Douglas S Conklin
RNA interference by short hairpin RNAs expressed in vertebrate cells.
Methods in molecular biology (Clifton, N.J.) 2004;257():255-66.
2003: Jose M Silva; Ravi Sachidanandam; Gregory J Hannon
Free energy lights the path toward more effective RNAi.
Nature genetics 2003;35(4):303-5.
2003: Ji-Joon Song; Jidong Liu; Niraj H Tolia; Jonathan Schneiderman; Stephanie K Smith; Robert A Martienssen; Gregory J Hannon; Leemor Joshua-Tor
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.
Nature structural biology 2003;10(12):1026-32.
2003: Emily Bernstein; Sang Yong Kim; Michelle A Carmell; Elizabeth P Murchison; Heather L Alcorn; Mamie Z Li; Alea A Mills; Stephen J Elledge; Kathryn V Anderson; Gregory J Hannon
Dicer is essential for mouse development.
Nature genetics 2003;35(3):215-7.
2003: Amy A Caudy; René F Ketting; Scott M Hammond; Ahmet M Denli; Anja M P Bathoorn; Bastiaan B J Tops; Jose M Silva; Mike M Myers; Gregory J Hannon; Ronald H Plasterk
A micrococcal nuclease homologue in RNAi effector complexes.
Nature 2003;425(6956):411-4.
2003: Masashi Narita; Sabrina Nũnez; Edith Heard; Masako Narita; Athena W Lin; Stephen A Hearn; David L Spector; Gregory J Hannon; Scott W Lowe
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Cell 2003;113(6):703-16.
2003: Patrick J Paddison; Gregory J Hannon
siRNAs and shRNAs: skeleton keys to the human genome.
Current opinion in molecular therapeutics 2003;5(3):217-24.
2003: Ahmet M Denli; Gregory J Hannon
RNAi: an ever-growing puzzle.
Trends in biochemical sciences 2003;28(4):196-201.
2003: Michael T Hemann; Jordan S Fridman; Jack T Zilfou; Eva Hernando; Patrick J Paddison; Carlos Cordon-Cardo; Gregory J Hannon; Scott W Lowe
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.
Nature genetics 2003;33(3):396-400.
2003: Michelle A Carmell; Liqun Zhang; Douglas S Conklin; Gregory J Hannon; Thomas A Rosenquist
Germline transmission of RNAi in mice.
Nature structural biology 2003;10(2):91-2.
2002: Jian Du; Gregory J Hannon
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.
Nucleic acids research 2002;30(24):5465-75.
2002: Yvette R Seger; Marta García-Cao; Sara Piccinin; Crocifissa Lo Cunsolo; Claudio Doglioni; María A Blasco; Gregory J Hannon; Roberta Maestro
Transformation of normal human cells in the absence of telomerase activation.
Cancer cell 2002;2(5):401-13.
2002: Michelle A Carmell; Zhenyu Xuan; Michael Q Zhang; Gregory J Hannon
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.
Genes & development 2002;16(21):2733-42.
2002: Amy A Caudy; Mike Myers; Gregory J Hannon; Scott M Hammond
Fragile X-related protein and VIG associate with the RNA interference machinery.
Genes & development 2002;16(19):2491-6.
2002: Patrick J Paddison; Gregory J Hannon
RNA interference: the new somatic cell genetics?
Cancer cell 2002;2(1):17-23.
2002: Gerardo Ferbeyre; Elisa de Stanchina; Athena W Lin; Emmanuelle Querido; Mila E McCurrach; Gregory J Hannon; Scott W Lowe
Oncogenic ras and p53 cooperate to induce cellular senescence.
Molecular and cellular biology 2002;22(10):3497-508.
2002: Patrick J Paddison; Amy A Caudy; Emily Bernstein; Gregory J Hannon; Douglas S Conklin
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells.
Genes & development 2002;16(8):948-58.
2002: Patrick J Paddison; Amy A Caudy; Gregory J Hannon
Stable suppression of gene expression by RNAi in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1443-8.
2001: JP Stolarov; K Chang; A Reiner; Linda Rodgers; Gregory J Hannon; Michael Wigler; V Mittal
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13043-8.
2001: Emily Bernstein; Ahmet M Denli; Gregory J Hannon
The rest is silence.
RNA (New York, N.Y.) 2001;7(11):1509-21.
2001: René F Ketting; SE Fischer; E Bernstein; Titia Sijen; Gregory J Hannon; Ronald H Plasterk
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.
Genes & development 2001;15(20):2654-9.
2001: Scott M Hammond; S Boettcher; Amy A Caudy; R Kobayashi; Gregory J Hannon
Argonaute2, a link between genetic and biochemical analyses of RNAi.
Science (New York, N.Y.) 2001;293(5532):1146-50.
2001: Scott M Hammond; Amy A Caudy; Gregory J Hannon
Post-transcriptional gene silencing by double-stranded RNA.
Nature reviews. Genetics 2001;2(2):110-9.
2001: Emily Bernstein; Amy A Caudy; Scott M Hammond; Gregory J Hannon
Role for a bidentate ribonuclease in the initiation step of RNA interference.
Nature 2001;409(6818):363-6.
2000: Amancio Carnero; James D Hudson; Gregory J Hannon; David H Beach
Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model.
Nucleic acids research 2000;28(11):2234-41.
2000: Scott M Hammond; Emily Bernstein; D Beach; Gregory J Hannon
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells.
Nature 2000;404(6775):293-6.
1999: James D Hudson; M A Shoaibi; Roberta Maestro; Amancio Carnero; Gregory J Hannon; David H Beach
A proinflammatory cytokine inhibits p53 tumor suppressor activity.
The Journal of experimental medicine 1999;190(10):1375-82.
1999: Roberta Maestro; Angelo P Dei Tos; Yasuo Hamamori; S Krasnokutsky; Vittorio Sartorelli; Larry Kedes; Claudio Doglioni; D H Beach; Gregory J Hannon
Twist is a potential oncogene that inhibits apoptosis.
Genes & development 1999;13(17):2207-17.
1999: Gregory J Hannon; P Sun; A Carnero; L Y Xie; Roberta Maestro; D S Conklin; D Beach
MaRX: an approach to genetics in mammalian cells.
Science (New York, N.Y.) 1999;283(5405):1129-30.
1998: P Sun; P Dong; K Dai; Gregory J Hannon; D Beach
p53-independent role of MDM2 in TGF-beta1 resistance.
Science (New York, N.Y.) 1998;282(5397):2270-2.
1998: K R LaMontagne; Gregory J Hannon; Nicholas K Tonks
Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14094-9.
1998: Howard Fearnhead; J Rodriguez; Eve-Ellen Govek; W Guo; R Kobayashi; Gregory J Hannon; Yuri Lazebnik
Oncogene-dependent apoptosis is mediated by caspase-9.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13664-9.
1998: Jing Wang; L Y Xie; S Allan; D Beach; Gregory J Hannon
Myc activates telomerase.
Genes & development 1998;12(12):1769-74.