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Torben Hansen

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Marie N Harder; Torben Jørgensen; Johanne M Justesen; Allan Linneberg; Ehm A Andersson; Niels Grarup; Torben Hansen; Rasmus Ribel-Madsen; Thomas Sparsø; Oluf Pedersen
Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort.
A Bonnefond; Guillaume Charpentier; Sébastien Czernichow; Aurélie Dechaume; I Ezzidi; philippe froguel; Anette P Gjesing; Samy HADJADJ; Torben Hansen; Serge Hercberg; O Lantieri; Michel Marre; Oluf Pedersen; Julien Philippe; Emmanuel Vaillant; E A Andersson; Beverley Balkau; L Yengo; Martine Vaxillaire
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.
G Andersen; S Anthonsen; JO Clausen; L T Dalgaard; Torben Hansen; J Holmkvist; T Jørgensen; J M Justesen; T Lauritzen; T Nielsen; L W Thørner; D Witte; Oluf Pedersen
The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.

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All Publications

2013: Marie N Harder; Torben Jørgensen; Johanne M Justesen; Allan Linneberg; Ehm A Andersson; Niels Grarup; Torben Hansen; Rasmus Ribel-Madsen; Thomas Sparsø; Oluf Pedersen
Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort.
The Journal of clinical endocrinology and metabolism 2013;98(4):E801-6.
2013: A Bonnefond; Guillaume Charpentier; Sébastien Czernichow; Aurélie Dechaume; I Ezzidi; philippe froguel; Anette P Gjesing; Samy HADJADJ; Torben Hansen; Serge Hercberg; O Lantieri; Michel Marre; Oluf Pedersen; Julien Philippe; Emmanuel Vaillant; E A Andersson; Beverley Balkau; L Yengo; Martine Vaxillaire
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.
Diabetologia 2013;56(3):492-6.
2013: G Andersen; S Anthonsen; JO Clausen; L T Dalgaard; Torben Hansen; J Holmkvist; T Jørgensen; J M Justesen; T Lauritzen; T Nielsen; L W Thørner; D Witte; Oluf Pedersen
The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.
International journal of obesity (2005) 2013;37(2):175-81.
2013: Linn Gillberg; Anette P Gjesing; Torben Hansen; Stine Jacobsen; Charlotte Ling; Oluf Pedersen; Rasmus Ribel-Madsen; Trine W Boesgaard; Allan Vaag
Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?
PloS one 2013;8(3):e58384.
2013: Amélie Bonnefond; Guillaume Charpentier; Aurélie Dechaume; Julia S El-Sayed Moustafa; philippe froguel; Niels Grarup; Samy HADJADJ; Torben Hansen; Serge Hercberg; Olivier Lantieri; Torsten Lauritzen; Michel Marre; Ndeye Coumba Ndiaye; Mohsen Azimi Nezhad; Oluf Pedersen; Ronan Roussel; Pierre-Jean Saulnier; Maria G Stathopoulou; Beverley Balkau; Sophie Visvikis-Siest
What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?
PloS one 2013;8(2):e55921.
2013: K Færch; Torben Hansen; Torben Jørgensen; F K Knop; Oluf Pedersen; K Pilgaard; Jens Juul Holst
Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.
Diabetes, obesity & metabolism 2013;15(1):91-5.
2012: Louise Kelstrup; Elisabeth R Mathiesen; Tine Dalsgaard Clausen; Torben Hansen; Peter Damm
Low-grade inflammation in young adults exposed to intrauterine hyperglycemia.
Diabetes research and clinical practice 2012;97(2):322-30.
2012: Anette P Gjesing; Hans Eiberg; Claus T Ekstrøm; Jens Juul Holst; Oluf Pedersen; Søren A Urhammer; Torben Hansen
Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits.
Diabetologia 2012;55(5):1338-45.
2012: Anders Borglykke; Mogens Fenger; Niels Grarup; Torben Hansen; Jørgen Jeppesen; Allan Linneberg; Oluf Pedersen; Thomas Sparsø; Torben Jørgensen
Genetic variant SCL2A2 is associated with risk of cardiovascular disease--assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants.
PloS one 2012;7(11):e50418.
2012: Tanja Stocks; Moira A Taylor; Lars Angquist; Peter Arner; Arne Astrup; Karina Banasik; Jörg Hager; Torben Hansen; Marie N Harder; Claus Holst; Yoichiro Kamatani; Marie Kunesova; Dominique Langin; Ian A MacDonald; J Alfredo Martinez; Jean-Michel Oppert; Oluf Pedersen; Andreas F H Pfeiffer; Jan Polak; Stephan Rössner; Francis Rousseau; Wim H M Saris; Thorkild I A Sørensen
TFAP2B influences the effect of dietary fat on weight loss under energy restriction.
PloS one 2012;7(8):e43212.
2012: Nikolaj Thure Krarup; Oluf Pedersen; Pernille Poulsen; Camilla Helene Sandholt; Thorkild Sørensen; Allan Vaag; Daniel R Witte; Karina Banasik; Kristine Færch; Martin Friedrichsen; Niels Grarup; Torben Jørgensen; Torben Hansen
The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation.
PloS one 2012;7(7):e40376.
2012: Karina Banasik; Ehm Andersson; Mette Hollensted; Torben Jørgensen; Torsten Lauritzen; Oluf Pedersen; Annelli Sandbaek; Thomas Sparsø; Daniel R Witte; Torben Hansen
The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals.
BMC medical genetics 2012;13():10.
2012: K S Burgdorf; Anette P Gjesing; Niels Grarup; Torben Hansen; Torben Jørgensen; J M Justesen; Sten Madsbad; C H Sandholt; Daniel R Witte; Oluf Pedersen
Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals.
Diabetologia 2012;55(1):105-13.
2011: Signe S Torekov; J Wang; Daniel R Witte; M Rosenkilde; Annelli Sandbaek; Niels Grarup; I A Hainerová; Torben Hansen; Bolette Hartmann; Jens Juul Holst; Torben Jørgensen; U Kielgast; Hannelouise Kissow; torsten lauritzen; J Lebl; A Linneberg; L Ma; Sten Madsbad; O D Madsen; Oluf Pedersen
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.
Diabetologia 2011;54(11):2820-31.
2011: Tune H Pers; Shaun Purcell; Thomas Werge; Christopher T Workman; Ole A Andreassen; Anders D Børglum; Henrik Dam; Srdjan Djurovic; Piotr Dworzynski; Manuel A Ferreira; Tracey J Flint; Niclas Tue Hansen; Torben Hansen; Pernille Koefoed; Irene Kouskoumvekaki; Kasper Lage; Ingrid Melle; Erling Mellerup; Martin Lee Miller; Ole Mors; Søren Brunak
Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes.
Genetic epidemiology 2011;35(5):318-32.
2011: T Nielsen; T Sparsø; N Grarup; Torben Jørgensen; Charlotta Pisinger; Daniel R Witte; Torben Hansen; Oluf Pedersen
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.
Diabetologia 2011;54(5):1052-6.
2011: Lucie Gonsorcikova; Torben Hansen; Oluf Pedersen; Stepanka Pruhova; Martine Vaxillaire; Ondrej Cinek; Aurélie Dechaume; Petra Dusatkova; philippe froguel; Jan Lebl
Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations.
Pediatric diabetes 2011;12(3 Pt 2):266-9.
2011: N Grarup; M Overvad; T Sparsø; Daniel R Witte; Charlotta Pisinger; Torben Jørgensen; T Yamauchi; K Hara; S Maeda; T Kadowaki; Torben Hansen; Oluf Pedersen
The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals.
Diabetologia 2011;54(4):789-94.
2011: Siri Fredheim; Lars Hansen; Torben Hansen; Henrik Bindesbøl Mortensen; Oluf Borbye Pedersen; Sven Pørksen; Jannet Svensson; Fabrizio Barbetti; Lotte Brøndum Nielsen
Intrafamilial Variability of Early-Onset Diabetes due to an INS Mutation.
Case reports in genetics 2011;2011():258978.
2011: Ehm A Andersson; Kristine Færch; Niels Grarup; Marie N Harder; Torben Jørgensen; Johanna Kuusisto; Markku Laakso; Oluf Pedersen; Kasper Pilgaard; Charlotta Pisinger; Pernille Poulsen; Alena Stančáková; Allan Vaag; Daniel R Witte; Torben Hansen
The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge.
PloS one 2011;6(11):e27096.
2011: Jacob P Thyssen; Berit C Carlsen; Kåre Engkilde; Torben Hansen; Jeanne D Johansen; Allan Linneberg; Michael Meldgaard; Oluf Pedersen; Flemming Pociot; Steen Stender; Pal B Szecsi; Torkil Menné
A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study.
BMJ open 2011;1(1):e000062.
2011: Anette P Gjesing; Torben Hansen; Martin Heni; Jens J Holst; Torben Jørgensen; Marie A Vestmar; Daniel R Witte; Oluf Pedersen
The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status.
PloS one 2011;6(9):e23907.
2011: Camilla Helene Sandholt; Marie Aare Vestmar; Daniel Witte; Katrine Almind; Dorthe Sadowa Bille; Anders Borglykke; Lars Hansen; Torben Jørgensen; Torsten Lauritzen; Oluf Pedersen; Annelli Sandbaek; Torben Hansen
Studies of metabolic phenotypic correlates of 15 obesity associated gene variants.
PloS one 2011;6(9):e23531.
2011: Anette P Gjesing; Torben Hansen; Torben Jørgensen; Aneta A Nielsen; Amélie Bonnefond; Ivan Brandslund; Cramer Christensen; Phillippe Froguel; Annelli Sandbaek; Daniel R Witte; Oluf Pedersen
Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes.
BMC medical genetics 2011;12():99.
2011: Dorthe S Bille; Torben Hansen; Jens-Christian Holm; Torben Jørgensen; Johanne M Justesen; Torsten Lauritzen; Annelli Sandbaek; Camilla H Sandholt; Daniel R Witte; Karina Banasik; Oluf Pedersen
Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes.
PloS one 2011;6(6):e20640.
2011: Karina Banasik; Johanne M Justesen; Malene Hornbak; Nikolaj T Krarup; Anette P Gjesing; Camilla H Sandholt; Thomas S Jensen; Niels Grarup; Asa Andersson; Torben Jørgensen; Daniel R Witte; Annelli Sandbaek; Torsten Lauritzen; Bernard Thorens; Søren Brunak; Thorkild I A Sørensen; Oluf Pedersen; Torben Hansen
Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease.
PloS one 2011;6(1):e16542.
2011: Esther Zimmermann; Kristin Skogstrand; David M Hougaard; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen; Tine Jess
Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index.
PloS one 2011;6(1):e15958.
2011: Malene Hornbak; Karina Banasik; Johanne M Justesen; Nikolaj T Krarup; Camilla H Sandholt; Åsa Andersson; Annelli Sandbaek; torsten lauritzen; Charlotta Pisinger; Daniel R Witte; Thorkild A A Sørensen; Oluf Pedersen; Torben Hansen
The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load.
BMC medical genetics 2011;12():4.
2011: Anette P Gjesing; L L Kjems; M A Vestmar; Niels Grarup; A Linneberg; C F Deacon; J J Holst; Oluf Pedersen; Torben Hansen
Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.
Diabetologia 2011;54(1):103-10.
2011: Karina Banasik; Rasmus Ribel-Madsen; Anette P Gjesing; Lise Wegner; Asa Andersson; Pernille Poulsen; Anders Borglykke; Daniel R Witte; Oluf Pedersen; Torben Hansen; Allan Vaag
The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins.
The Journal of clinical endocrinology and metabolism 2011;96(1):E119-24.
2010: K Pilgaard; K Færch; B Carstensen; Pernille Poulsen; C Pisinger; Oluf Pedersen; Daniel R Witte; Torben Hansen; Torben Jørgensen; Allan Vaag
Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes.
Diabetologia 2010;53(12):2526-30.
2010: Stepanka Pruhova; Petra Dusatkova; Zdenek Sumnik; Stanislava Kolouskova; Oluf Pedersen; Torben Hansen; Ondrej Cinek; Jan Lebl
Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations.
Pediatric diabetes 2010;11(8):529-35.
2010: Stéphanie Le Hellard; T W Mühleisen; S Djurovic; Johan Fernø; Z Ouriaghi; M Mattheisen; C Vasilescu; Maria Baroy Raeder; Torben Hansen; J Strohmaier; A Georgi; F F Brockschmidt; Ingrid Melle; I Nenadic; H Sauer; M Rietschel; M M Nöthen; T Werge; Ole A Andreassen; S Cichon; Vidar M Steen
Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.
Molecular psychiatry 2010;15(5):463-72.
2010: Ehm A Andersson; Kasper Pilgaard; Charlotta Pisinger; Marie N Harder; Niels Grarup; Kristine Færch; Camilla Sandholt; Pernille Poulsen; Daniel R Witte; Torben Jørgensen; Allan Vaag; Oluf Pedersen; Torben Hansen
Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.
PloS one 2010;5(12):e14190.
2010: Anette P Gjesing; Lesli H Larsen; Signe S Torekov; Irena Aldhoon Hainerová; Rahul Kapur; Anders Johansen; Anders Albrechtsen; Sylvia Boj; Birgitte Holst; Angela Harper; Søren A Urhammer; Knut Borch-Johnsen; Charlotta Pisinger; Søren M Echwald; Hans Eiberg; Arne Astrup; Jan Lebl; Jorge Ferrer; Thue W Schwartz; Torben Hansen; Oluf Pedersen
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity.
PloS one 2010;5(4):e10084.
2010: Trine W Boesgaard; Stepanka Pruhova; Ehm A Andersson; Ondrej Cinek; Barbora Obermannova; Jeannet Lauenborg; Peter Damm; Regine Bergholdt; Flemming Pociot; Charlotta Pisinger; Fabrizio Barbetti; Jan Lebl; Oluf Pedersen; Torben Hansen
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
BMC medical genetics 2010;11():42.
2010: S I I Kring; Claus Holst; Søren Toubro; Arne Astrup; Torben Hansen; Oluf Pedersen; T I A Sørensen
Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.
International journal of obesity (2005) 2010;34(1):182-9.
2010: Janniche Torsvik; Stefan Johansson; Anders Johansen; Jakob Ek; Jayne Minton; Helge Raeder; Sian Ellard; Andrew Hattersley; Oluf Pedersen; Torben Hansen; Anders Molven; Pål R Njølstad
Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes.
Human genetics 2010;127(1):55-64.
2009: Louise G Grunnet; Emma Nilsson; Charlotte Ling; Torben Hansen; Oluf Pedersen; Leif Groop; Allan Vaag; Pernille Poulsen
Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue.
Diabetes 2009;58(10):2402-8.
2009: T W Boesgaard; T T Nielsen; K Josefsen; Torben Hansen; Torben Jørgensen; Oluf Pedersen; A Nørremølle; J E Nielsen; L Hasholt
Huntington's disease does not appear to increase the risk of diabetes mellitus.
Journal of neuroendocrinology 2009;21(9):770-6.
2009: Erwin Reiling; Jana V van Vliet-Ostaptchouk; Esther van 't Riet; Timon W van Haeften; Pascal A Arp; Torben Hansen; Dennis Kremer; Marlous J Groenewoud; Els C van Hove; Johannes A Romijn; Jan W A Smit; Giel Nijpels; Robert J Heine; André G Uitterlinden; Oluf Pedersen; P Eline Slagboom; J Antonie Maassen; Marten H Hofker; Leen M 't Hart; Jacqueline M Dekker
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.
European journal of human genetics : EJHG 2009;17(8):1056-62.
2009: Tine D Clausen; Elisabeth R Mathiesen; Torben Hansen; Oluf Pedersen; Dorte Møller Jensen; Jeannet Lauenborg; Lone Schmidt; Peter Damm
Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2009;94(7):2464-70.
2009: Thomas Sparsø; Niels Grarup; C Andreasen; Anders Albrechtsen; J Holmkvist; Gitte Andersen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Sten Madsbad; Torben Hansen; Oluf Pedersen
Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction.
Diabetologia 2009;52(7):1308-14.
2009: K Pilgaard; C B Jensen; J H Schou; V Lyssenko; Lise Wegner; Charlotte Brøns; T Vilsbøll; Torben Hansen; Sten Madsbad; J J Holst; A Vølund; Pernille Poulsen; Leif Groop; Oluf Pedersen; Allan Vaag
The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.
Diabetologia 2009;52(7):1298-307.
2009: Mette Høj Lauridsen; Trine Welløv Boesgaard; Oluf Borbye Pedersen; Torben Hansen; Birgitte Hertz
[Diabetes in infants may be treated with sulfonylurea as a replacement for insulin].
Ugeskrift for laeger 2009;171(23):1923-4.
2009: Thomas Sparsø; Amélie Bonnefond; Ehm Andersson; Nabila Bouatia-Naji; Johan Holmkvist; Lise Wegner; Niels Grarup; Anette P Gjesing; Karina Banasik; Christine Cavalcanti-Proença; Marion Marchand; Martine Vaxillaire; Guillaume Charpentier; Marjo-Riitta Jarvelin; Jean Tichet; Beverley Balkau; Michel Marre; Claire Lévy-Marchal; Kristine Faerch; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Pernille Poulsen; Allan Vaag; Christian Dina; Torben Hansen; Oluf Pedersen; philippe froguel
G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.
Diabetes 2009;58(6):1450-6.
2009: Thomas V O Hansen; Bent Ejlertsen; Anders Albrechtsen; Eva Bergsten; Peter Bjerregaard; Torben Hansen; Torben Myrhøj; Peter B Nielsen; Vera Timmermans-Wielenga; Mette K Andersen; Lars Jønson; Finn C Nielsen
A common Greenlandic Inuit BRCA1 RING domain founder mutation.
Breast cancer research and treatment 2009;115(1):69-76.
2009: Dorit P Zobel; Camilla H Andreasen; Kristoffer S Burgdorf; Ehm A Andersson; Annelli Sandbaek; Torsten Lauritzen; Knut Borch-Johnsen; Torben Jørgensen; Shiro Maeda; Yusuke Nakamura; Hans Eiberg; Oluf Pedersen; Oluf Pederse; Torben Hansen
Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):603-9.
2009: T Gylvin; Jakob Ek; Runa Louise Nolsoe; Anders Albrechtsen; Gitte Andersen; Regine Bergholdt; C Brorsson; C H Bang-Berthelsen; Torben Hansen; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.
Diabetes, obesity & metabolism 2009;11(3):196-203.
2009: Trine Welløv Boesgaard; Anette P Gjesing; Niels Grarup; Jarno Rutanen; Per-Anders Jansson; Marta Letizia Hribal; Giorgio Sesti; Andreas Fritsche; Norbert Stefan; Harald Staiger; Hans Häring; Ulf Smith; Markku Laakso; Oluf Pedersen; Torben Hansen
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.
PloS one 2009;4(9):e7236.
2009: Anette P Gjesing; Thomas Sparsø; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen; Niels V Olsen
No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes.
PloS one 2009;4(9):e7206.
2009: Sofia I I Kring; Thomas Werge; Claus Holst; Søren Toubro; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen
Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes.
PloS one 2009;4(8):e6696.
2009: Camilla Noelle Rathcke; Johan Holmkvist; Lise Lotte N Husmoen; Torben Hansen; Oluf Pedersen; Henrik Vestergaard; Allan Linneberg
Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.
PloS one 2009;4(7):e6106.
2009: Camilla Noelle Rathcke; Johan Holmkvist; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Borbye Pedersen; Henrik Vestergaard
Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits.
PloS one 2009;4(5):e5469.
2009: Esther Zimmermann; Sofia I I Kring; Tina L Berentzen; Claus Holst; Tune H Pers; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen; Tine Jess
Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men.
PloS one 2009;4(2):e4428.
2009: Jeannet Lauenborg; Niels Grarup; Peter Damm; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Common type 2 diabetes risk gene variants associate with gestational diabetes.
The Journal of clinical endocrinology and metabolism 2009;94(1):145-50.
2008: Trine Nielsen; Kristoffer Sølvsten Burgdorf; Niels Grarup; Knut Borch-Johnsen; Torben Hansen; Torben Jørgensen; Oluf Pedersen; Gitte Andersen
The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes.
Journal of hypertension 2008;26(11):2142-6.
2008: Birgitte Lindegaard; Torben Hansen; T Hvid; Gerrit van Hall; Peter Plomgaard; Susanne Ditlevsen; Jan Gerstoft; Bente Klarlund Pedersen
The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy.
The Journal of clinical endocrinology and metabolism 2008;93(10):3860-9.
2008: Tine Jess; Esther Zimmermann; S I I Kring; Tina Berentzen; Claus Holst; Søren Toubro; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen
Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study.
International journal of obesity (2005) 2008;32(9):1388-94.
2008: Thomas Sparsø; Gitte Andersen; Anders Albrechtsen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; J Wasson; M A Permutt; B Glaser; Sten Madsbad; Oluf Pedersen; Torben Hansen
Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation.
Diabetologia 2008;51(9):1646-52.
2008: Niels Grarup; Gitte Andersen; Nikolaj T Krarup; Anders Albrechtsen; Ole Schmitz; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.
Diabetes 2008;57(9):2534-40.
2008: Ruth Gutiérrez-Aguilar; philippe froguel; Yasmin H Hamid; Yamina Benmezroua; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen; Bernadette Neve
Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C.
The Journal of clinical endocrinology and metabolism 2008;93(8):3128-35.
2008: Lucie Gonsorcíková; Stepánka Průhová; Ondrej Cinek; Jakob Ek; Terezie Pelikánová; Torben Jørgensen; Hans Eiberg; Oluf Pedersen; Torben Hansen; Jan Lebl
Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1.
Pediatric diabetes 2008;9(4 Pt 2):367-72.
2008: A Jorsal; Lise Tarnow; Maria Lajer; Jakob Ek; Torben Hansen; Oluf Pedersen; Hans-Henrik Parving
The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy.
Molecular genetics and metabolism 2008;94(3):347-51.
2008: Niels Grarup; Camilla H Andreasen; Mette K Andersen; Anders Albrechtsen; Annelli Sandbaek; Torsten Lauritzen; Knut Borch-Johnsen; Torben Jørgensen; Ole Schmitz; Torben Hansen; Oluf Pedersen
The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.
The Journal of clinical endocrinology and metabolism 2008;93(6):2294-9.
2008: T W Boesgaard; J Zilinskaite; Markku Vänttinen; Markku Laakso; Per-Anders Jansson; Ann Hammarstedt; Ulf Smith; Norbert Stefan; A Fritsche; H Häring; M Hribal; Giorgio Sesti; D P Zobel; Oluf Pedersen; Torben Hansen
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.
Diabetologia 2008;51(5):816-20.
2008: Gitte Andersen; Kristoffer Sølvsten Burgdorf; Thomas Sparsø; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects.
Diabetes 2008;57(5):1427-32.
2008: A P Gjesing; Gitte Andersen; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people.
Molecular genetics and metabolism 2008;94(1):90-7.
2008: J Holmkvist; S Anthonsen; Lise Wegner; Gitte Andersen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Oluf Pedersen; Torben Hansen
Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result.
Diabetologia 2008;51(4):609-14.
2008: Niels Grarup; Kirstine L Stender-Petersen; Ehm A Andersson; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Ole Schmitz; Torben Hansen; Oluf Pedersen
Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects.
Diabetes 2008;57(4):1136-42.
2008: Torben Hansen; Oluf Borbye Pedersen
[Genetics in non-autoimmune diabetes. The Danish Society of Endocrinology].
Ugeskrift for laeger 2008;170(12):1021.
2008: Tine D Clausen; Elisabeth R Mathiesen; Torben Hansen; Oluf Pedersen; Dorte Møller Jensen; Jeannet Lauenborg; Peter Damm
High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia.
Diabetes care 2008;31(2):340-6.
2008: Sofia Inez Iqbal Kring; Lesli Hingstrup Larsen; Claus Holst; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Thorkild I A Sørensen
Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype.
Obesity facts 2008;1(3):138-45.
2008: Sofia I I Kring; Claus Holst; Esther Zimmermann; Tine Jess; Tina Berentzen; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Thorkild I A Sørensen
FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness.
PloS one 2008;3(8):e2958.
2008: Camilla H Andreasen; Mette S Mogensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Thorkild I A Sørensen; Lars Hansen; Katrine Almind; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes.
PloS one 2008;3(8):e2872.
2008: Thomas Sparsø; Gitte Andersen; T Nielsen; K S Burgdorf; A P Gjesing; A L Nielsen; Anders Albrechtsen; Signe S Rasmussen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Sten Madsbad; Torben Hansen; Oluf Pedersen
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
Diabetologia 2008;51(1):70-5.
2008: Camilla H Andreasen; Kirstine L Stender-Petersen; Mette S Mogensen; Signe S Torekov; Lise Wegner; Gitte Andersen; Arne L Nielsen; Anders Albrechtsen; Knut Borch-Johnsen; Signe S Rasmussen; Jesper O Clausen; Annelli Sandbaek; Torsten Lauritzen; Lars Hansen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation.
Diabetes 2008;57(1):95-101.
2007: Niels Grarup; Christian Schack Rose; Ehm A Andersson; Gitte Andersen; Arne L Nielsen; Anders Albrechtsen; Jesper O Clausen; Signe S Rasmussen; Torben Jørgensen; Annelli Sandbaek; Torsten Lauritzen; Ole Schmitz; Torben Hansen; Oluf Pedersen
Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.
Diabetes 2007;56(12):3105-11.
2007: Thomas Sparsø; Meena Shaheen Hussain; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Torben Hansen; Oluf Pedersen; Gitte Andersen
Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites.
Molecular genetics and metabolism 2007;92(3):278-82.
2007: Irena Hainerová; Lesli H Larsen; Birgitte Holst; Marie Finková; Vojtech Hainer; Jan Lebl; Torben Hansen; Oluf Pedersen
Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis.
The Journal of clinical endocrinology and metabolism 2007;92(9):3689-96.
2007: C Ling; Lise Wegner; Gitte Andersen; Peter Almgren; Torben Hansen; Oluf Pedersen; Leif Groop; Allan Vaag; Pernille Poulsen
Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle.
Diabetologia 2007;50(8):1615-20.
2007: T W Boesgaard; S I Castella; Gitte Andersen; Anders Albrechtsen; Thomas Sparsø; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(7):702-6.
2007: Anders Albrechtsen; Sofie Castella; Gitte Andersen; Torben Hansen; Oluf Pedersen; Rasmus Nielsen
A Bayesian multilocus association method: allowing for higher-order interaction in association studies.
Genetics 2007;176(2):1197-208.
2007: Niels Grarup; Anders Albrechtsen; Jakob Ek; Knut Borch-Johnsen; Torben Jørgensen; Ole Schmitz; Torben Hansen; Oluf Pedersen
Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people.
Diabetologia 2007;50(6):1201-8.
2007: Dorit P Jensen; Camilla H Andreasen; Mette K Andersen; Lars Hansen; Hans Eiberg; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites.
Journal of molecular medicine (Berlin, Germany) 2007;85(5):445-9.
2007: Anette P Gjesing; Gitte Andersen; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(4):392-7.
2007: Lise Wegner; Gitte Andersen; Thomas Sparsø; Niels Grarup; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.
Diabetes 2007;56(3):694-8.
2007: Anette P Gjesing; Gitte Andersen; K S Burgdorf; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of the associations between functional beta2-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects.
Diabetologia 2007;50(3):563-8.
2007: Torben Hansen; Thomas Drivsholm; Søren A Urhammer; Rene T Palacios; Aage Voelund; Knut Borch-Johnsen; Oluf Pedersen
The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance.
Diabetes care 2007;30(2):257-62.
2007: Thomas Sparsø; Meena S Hussain; Gitte Andersen; Irena Hainerova; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people.
Molecular genetics and metabolism 2007;90(2):205-9.
2007: Lesli H Larsen; Christian Schack Rose; Thomas Sparsø; J Overgaard; Signe S Torekov; Niels Grarup; Dorit P Jensen; Anders Albrechtsen; Gitte Andersen; Jakob Ek; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes.
International journal of obesity (2005) 2007;31(2):365-70.
2007: Daniela Pinterova; Jakob Ek; Katarina Kolostova; Stepanka Pruhova; Peter Novota; Marianna Romzova; E Feigerlova; Marie Cerna; Jan Lebl; Oluf Pedersen; Torben Hansen
Six novel mutations in the GCK gene in MODY patients.
Clinical genetics 2007;71(1):95-6.
2007: Niels Grarup; Mette K Andersen; Camilla H Andreasen; Anders Albrechtsen; Knut Borch-Johnsen; Torben Jørgensen; Johan Auwerx; Ole Schmitz; Torben Hansen; Oluf Pedersen
Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects.
The Journal of clinical endocrinology and metabolism 2007;92(1):363-6.
2006: Irena Hainerová; Signe S Torekov; Jakob Ek; Marie Finková; Knut Borch-Johnsen; Torben Jørgensen; Ole D Madsen; Jan Lebl; Torben Hansen; Oluf Pedersen
Association between neuromedin U gene variants and overweight and obesity.
The Journal of clinical endocrinology and metabolism 2006;91(12):5057-63.
2006: Dorit P Jensen; Søren A Urhammer; Hans Eiberg; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites.
Molecular genetics and metabolism 2006;89(4):360-7.
2006: Els C van Hove; Torben Hansen; Jacqueline M Dekker; Erwin Reiling; Giel Nijpels; Torben Jørgensen; Knut Borch-Johnsen; Yasmin H Hamid; Robert J Heine; Oluf Pedersen; J Antonie Maassen; Leen M 't Hart
The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study.
Diabetes 2006;55(11):3193-6.
2006: Signe S Torekov; Lesli H Larsen; Gitte Andersen; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects.
Diabetologia 2006;49(11):2653-8.
2006: Lise Wegner; Gitte Andersen; Anders Albrechtsen; Thomas Sparsø; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(10):1140-4.
2006: Pernille Koefoed Theil; Line Kessel; Torben Hansen; Henrik Lund-Andersen; Oluf Pedersen; Michael Larsen
Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study.
Current eye research 2006;31(9):733-8.
2006: Niels Grarup; Søren A Urhammer; Jakob Ek; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.
Diabetologia 2006;49(9):2097-104.
2006: E Feigerlová; Stepánka Pruhová; Ludmila Dittertová; Jan Lebl; D Pinterová; K Kolostová; Milena Cerná; Oluf Pedersen; Torben Hansen
Aetiological heterogeneity of asymptomatic hyperglycaemia in children and adolescents.
European journal of pediatrics 2006;165(7):446-52.
2006: Jakob Ek; Sara P Hansen; Maria Lajer; Carine Nicot; Trine W Boesgaard; Stepanka Pruhova; Anders Johansen; Anders Albrechtsen; Knud Yderstraede; Jeannet Lauenborg; Marcelina Parrizas; Sylvia F Boj; Torben Jørgensen; Knut Borch-Johnsen; Peter Damm; Jorge Ferrer; Jan Lebl; Oluf Pedersen; Torben Hansen
A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes.
Diabetes 2006;55(6):1869-73.
2006: Runa Louise Nolsoe; Yasmin H Hamid; Flemming Pociot; S Paulsen; K M Andersen; Knut Borch-Johnsen; Thomas Drivsholm; Torben Hansen; Oluf Pedersen; Thomas Mandrup-Poulsen
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.
Genes and immunity 2006;7(4):316-21.
2006: Hans Eiberg; Lars Hansen; Birgit Kjer; Torben Hansen; Oluf Pedersen; Michael Bille; Thomas Rosenberg; Lisbeth Tranebjaerg
Autosomal dominant optic atrophy associated with hearing impairment and impaired glucose regulation caused by a missense mutation in the WFS1 gene.
Journal of medical genetics 2006;43(5):435-40.
2006: Anders Johansen; Dorit P Jensen; Regine Bergholdt; H B Mortensen; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
Diabetes, obesity & metabolism 2006;8(1):75-82.
2006: Gitte Andersen; J Overgaard; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes.
Diabetologia 2006;49(1):75-82.
2005: Christian Schack Rose; Jakob Ek; Søren A Urhammer; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.
Diabetes 2005;54(10):3026-31.
2005: Anders Johansen; Jakob Ek; H B Mortensen; Oluf Pedersen; Torben Hansen
Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1.
The Journal of clinical endocrinology and metabolism 2005;90(8):4607-14.
2005: Signe S Torekov; Lesli H Larsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Jens J Holst; Ole D Madsen; Torben Hansen; Oluf Pedersen
Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes.
Diabetes 2005;54(7):2261-5.
2005: Christian Schack Rose; Gitte Andersen; Yasmin H Hamid; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Studies of relationships between the GLUT10 Ala206Thr polymorphism and impaired insulin secretion.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(7):946-9.
2005: Jeannet Lauenborg; Elisabeth R Mathiesen; Torben Hansen; Charlotte Glümer; Torben Jørgensen; Knut Borch-Johnsen; Peter Hornnes; Oluf Pedersen; Peter Damm
The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population.
The Journal of clinical endocrinology and metabolism 2005;90(7):4004-10.
2005: Thomas M Larsen; Lesli H Larsen; Signe K Torekov; Jakob Ek; Eva Black; Søren Toubro; Arne Astrup; Thorkild I A Sørensen; Torben Hansen; Oluf Pedersen
Novel variants in the putative peroxisome proliferator-activated receptor {gamma} promoter and relationships with obesity in men.
Obesity research 2005;13(6):953-8.
2005: Leen M 't Hart; Torben Hansen; Ingrid Rietveld; Jacqueline M Dekker; Giel Nijpels; George M C Janssen; Pascal A Arp; André G Uitterlinden; Torben Jørgensen; Knut Borch-Johnsen; Huibert A P Pols; Oluf Pedersen; C.M. Duijn; Robert J Heine; J Antonie Maassen
Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.
Diabetes 2005;54(6):1892-5.
2005: Sara K Hansen; Eva-Maria D Nielsen; Jakob Ek; Gitte Andersen; Charlotte Glümer; Bendix Carstensen; Peter Mouritzen; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2005;90(6):3629-37.
2005: G Andersen; Torben Hansen; Oluf Pedersen
Genetics of common forms of glycaemia with pathological impact on vascular biology: are we on the right track?
Current molecular medicine 2005;5(3):261-74.
2005: Gitte Andersen; Lise Wegner; K Yanagisawa; Christian Schack Rose; Jiandie Lin; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Bruce M Spiegelman; Oluf Pedersen
Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Journal of medical genetics 2005;42(5):402-7.
2005: Ewan R Pearson; Stepanka Pruhova; C J Tack; Anders Johansen; H A J Castleden; P J Lumb; Anthony S Wierzbicki; Penny M Clark; Jan Lebl; Oluf Pedersen; Sian Ellard; Torben Hansen; Andrew T Hattersley
Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection.
Diabetologia 2005;48(5):878-85.
2005: Eva-Maria D Nielsen; Lars Hansen; Trine Stissing; Keiko Yanagisawa; Knut Borch-Johnsen; Pernille Poulsen; Allan Vaag; Torben Hansen; Oluf Pedersen
Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits.
Journal of molecular medicine (Berlin, Germany) 2005;83(5):353-61.
2005: Lesli H Larsen; Anette P Gjesing; Thorkild I A Sørensen; Yasmin H Hamid; Søren M Echwald; Søren Toubro; Eva Black; Arne Astrup; Torben Hansen; Oluf Pedersen
Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes.
Clinical biochemistry 2005;38(5):420-4.
2005: Jakob Ek; Christian Schack Rose; Dorit P Jensen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes.
The Journal of clinical endocrinology and metabolism 2005;90(5):3054-9.
2005: Jørn V Sagen; Ewan R Pearson; Anders Johansen; G Spyer; Oddmund Søvik; Oluf Pedersen; Pål R Njølstad; Andrew T Hattersley; Torben Hansen
Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(4):406-9.
2005: Gitte Andersen; Lise Wegner; Dorit P Jensen; Charlotte Glümer; Lise Tarnow; Thomas Drivsholm; Pernille Poulsen; Sara Kristine Hansen; Eva-Maria D Nielsen; Jakob Ek; Peter Mouritzen; Allan Vaag; Hans-Henrik Parving; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites.
Hypertension 2005;45(4):565-70.
2005: Bernadette Neve; Martin E Fernandez Zapico; Vered Ashkenazi-Katalan; Christian Dina; Yasmin H Hamid; Erik Joly; Emmanuel Vaillant; Yamina Benmezroua; Emmanuelle Durand; Nicolas Bakaher; Valérie Delannoy; Martine Vaxillaire; Tiffany Cook; Geesje M Dallinga-Thie; Hans Jansen; Marie-Aline Charles; Karine Clément; Pilar Galan; Serge Hercberg; Nicole Helbecque; Guillaume Charpentier; Marc Prentki; Torben Hansen; Oluf Pedersen; Raul Urrutia; Danielle Melloul; philippe froguel
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4807-12.
2005: Sara K Hansen; Christian Schack Rose; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.
Diabetologia 2005;48(3):452-8.
2005: Yasmin H Hamid; Søren A Urhammer; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
The common T60N polymorphism of the lymphotoxin-alpha gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome.
Diabetologia 2005;48(3):445-51.
2005: Yasmin H Hamid; Christian Schack Rose; Søren A Urhammer; Charlotte Glümer; Runa Louise Nolsoe; Ole P Kristiansen; Thomas Mandrup-Poulsen; Knut Borch-Johnsen; T Jorgensen; Torben Hansen; Oluf Pedersen
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.
Diabetologia 2005;48(2):251-60.
2005: Yasmin H Hamid; Henrik Vissing; B Holst; Søren A Urhammer; C Pyke; Sara K Hansen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; T W Schwartz; Oluf Pedersen; Torben Hansen
Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(1):74-80.
2005: Kirstine L Andersen; Søren M Echwald; Lesli H Larsen; Yasmin H Hamid; Charlotte Glümer; Torben Jørgensen; Knut Borch-Johnsen; Teis Andersen; Thorkild I A Sørensen; Torben Hansen; Oluf Pedersen
Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity.
The Journal of clinical endocrinology and metabolism 2005;90(1):225-30.
2004: Jeannet Lauenborg; Peter Damm; Jakob Ek; Charlotte Glümer; Torben Jørgensen; Knut Borch-Johnsen; H Vestergaard; Peter Hornnes; Oluf Pedersen; Torben Hansen
Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(12):1310-5.
2004: Yasmin H Hamid; Søren A Urhammer; Dorit P Jensen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites.
Diabetes 2004;53(12):3342-5.
2004: Gitte Andersen; Lise Wegner; Christian Schack Rose; Jianxin Xie; Hao Zhu; Kevin Larade; Anders Johansen; Jakob Ek; Jeannet Lauenborg; Thomas Drivsholm; Knut Borch-Johnsen; Peter Damm; Torben Hansen; H Franklin Bunn; Oluf Pedersen
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
Diabetes 2004;53(11):2992-7.
2004: Eva-Maria D Nielsen; Lars Hansen; Maria Lajer; Kirstine L Andersen; Søren M Echwald; Søren A Urhammer; Torben Hansen; Oluf Pedersen
A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects.
Clinical biochemistry 2004;37(8):660-5.
2004: Anders Johansen; Eva-Maria D Nielsen; Gitte Andersen; Yasmin H Hamid; Dorit P Jensen; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion.
Diabetologia 2004;47(8):1437-41.
2004: T Gylvin; Runa Louise Nolsoe; Torben Hansen; E M D Nielsen; Regine Bergholdt; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Sara K Hansen; Anette P Gjesing; Søren K Rasmussen; Charlotte Glümer; Søren A Urhammer; Gitte Andersen; Christian Schack Rose; Thomas Drivsholm; S K Torekov; Dorit P Jensen; Claus T Ekstrøm; Knut Borch-Johnsen; Torben Jørgensen; M I McCarthy; Torben Hansen; Oluf Pedersen
Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.
Diabetologia 2004;47(6):1079-87.
2004: Jeannet Lauenborg; Torben Hansen; Dorte Møller Jensen; Henrik Vestergaard; Lars Mølsted-Pedersen; Peter Hornnes; Henning Locht; Oluf Pedersen; Peter Damm
Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population.
Diabetes care 2004;27(5):1194-9.
2004: Frantisek Saudek; Stepánka Průhová; Petr Boucek; Jan Lebl; Milos Adamec; Jakob Ek; Oluf Pedersen; Torben Hansen
Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?
Transplantation 2004;77(8):1298-301.
2003: Louise Torp Dalgaard; Gitte Andersen; Lesli H Larsen; Thorkild I A Sørensen; Teis Andersen; Thomas Drivsholm; Knut Borch-Johnsen; Jan Fleckner; Torben Hansen; Nanni Din; Oluf Pedersen
Mutational analysis of the UCP2 core promoter and relationships of variants with obesity.
Obesity research 2003;11(11):1420-7.
2003: K Yanagisawa; L Hingstrup Larsen; Gitte Andersen; Thomas Drivsholm; Anna Cederberg; Rickard Westergren; Knut Borch-Johnsen; Oluf Pedersen; Sven Enerbäck; Torben Hansen
The FOXC2 -512C>T variant is associated with hypertriglyceridaemia and increased serum C-peptide in Danish Caucasian glucose-tolerant subjects.
Diabetologia 2003;46(11):1576-80.
2003: Gitte Andersen; Christian Schack Rose; Yasmin H Hamid; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits.
Diabetes 2003;52(9):2445-8.
2003: Eva-Maria D Nielsen; Lars Hansen; Søren M Echwald; Thomas Drivsholm; Knut Borch-Johnsen; Claus T Ekstrøm; Torben Hansen; Oluf Pedersen
Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects.
Pharmacogenetics 2003;13(7):417-23.
2003: J Pildal; Maria Lajer; Sara K Hansen; Katrine Almind; Louise Ambye; Knut Borch-Johnsen; Bendix Carstensen; Torben Hansen; Oluf Pedersen
Studies of variability in the islet amyloid polypeptide gene in relation to Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(6):491-4.
2003: Timothy M Frayling; Cecilia M Lindgren; Jean Claude Chevre; Stephan Menzel; Marie Wishart; Yamina Benmezroua; Alison Brown; Julie C Evans; Pamidghantam Subba Rao; Christian Dina; Cécile Lecoeur; Timo Kanninen; Peter Almgren; Michael P Bulman; Youxiang Wang; James Mills; Rosemarie Wright-Pascoe; Melanie M Mahtani; Francesco Prisco; Angels Costa; Ignacio Cognet; Torben Hansen; Oluf Pedersen; Sian Ellard; Tiinamaija Tuomi; Leif C Groop; philippe froguel; Andrew T Hattersley; Martine Vaxillaire
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
Diabetes 2003;52(3):872-81.
2003: Stepanka Pruhova; Jakob Ek; Jan Lebl; Zdenek Sumnik; Frantisek Saudek; Michal Andel; Oluf Pedersen; Torben Hansen
Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha.
Diabetologia 2003;46(2):291-5.
2003: Eva-Maria D Nielsen; Lars Hansen; Bendix Carstensen; Søren M Echwald; Thomas Drivsholm; Charlotte Glümer; Birger Thorsteinsson; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.
Diabetes 2003;52(2):573-7.
2002: Søren K Rasmussen; Søren A Urhammer; Lars Berglund; Jan N Jensen; Lars Hansen; Søren M Echwald; Knut Borch-Johnsen; Yukio Horikawa; Hirosato Mashima; Hans Lithell; Nancy J Cox; Torben Hansen; Graeme I Bell; Oluf Pedersen
Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
Diabetes 2002;51(12):3561-7.
2002: Michael P Bulman; L W Harries; Torben Hansen; Maggie Shepherd; W F Kelly; Andrew T Hattersley; Sian Ellard
Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young.
Diabetologia 2002;45(10):1463-7.
2002: Simon M S Mitchell; Martine Vaxillaire; Heike Thomas; Marcelina Parrizas; Yamina Benmezroua; Angels Costa; Torben Hansen; Katharine R Owen; Tiinamaija Tuomi; F Pirie; Gerhart U Ryffel; J Ferrer; philippe froguel; Andrew T Hattersley; Timothy M Frayling
Rare variants identified in the HNF- 4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes.
Diabetologia 2002;45(9):1344-8.
2002: Sara K Hansen; Marcelina Parrizas; Maria L Jensen; Stepanka Pruhova; Jakob Ek; Sylvia F Boj; Anders Johansen; Miguel A Maestro; Francisca Rivera; Hans Eiberg; Michal Andel; Jan Lebl; Oluf Pedersen; Jorge Ferrer; Torben Hansen
Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.
The Journal of clinical investigation 2002;110(6):827-33.
2002: Oluf Borbye Pedersen; Torben Hansen; Lars Hansen; Søren M Echwald; Søren A Urhammer
[Chasing the genetic determinants of the presumed polygenic forms of type 2 diabetes. Status and perspectives].
Ugeskrift for laeger 2002;164(16):2163-6.
2002: Torben Hansen; Søren A Urhammer; Oluf Borbye Pedersen
[Maturity-onset diabetes of the young--MODY. Molecular-genetic, pathophysiological and clinical characteristics].
Ugeskrift for laeger 2002;164(15):2017-22.
2002: Amanda Stride; Martine Vaxillaire; Tiinamaija Tuomi; Fabrizio Barbetti; Pål R Njølstad; Torben Hansen; Angels Costa; I Conget; Oluf Pedersen; Oddmund Søvik; Renata Lorini; L Groop; philippe froguel; Andrew T Hattersley
The genetic abnormality in the beta cell determines the response to an oral glucose load.
Diabetologia 2002;45(3):427-35.
2002: Torben Hansen
Type 2 diabetes mellitus--a multifactorial disease.
Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina 2002;57(1):544-9.
2002: Søren M Echwald; Helle Bach; Henrik Vestergaard; Bjørn Richelsen; Kurt Kristensen; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro.
Diabetes 2002;51(1):1-6.
2001: Jakob Ek; Gitte Andersen; Søren A Urhammer; P H Gaede; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus.
Diabetologia 2001;44(12):2220-6.
2001: Torben Hansen; Louise Ambye; N Grarup; Lars Hansen; Søren M Echwald; J Ferrer; Oluf Pedersen
Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus.
Diabetologia 2001;44(10):1330-4.
2001: Jakob Ek; Niels Grarup; Søren A Urhammer; P H Gaede; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Studies of the variability of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function.
Human mutation 2001;18(4):356-7.
2001: Jakob Ek; Gitte Andersen; Søren A Urhammer; Lars Hansen; Bendix Carstensen; Knut Borch-Johnsen; Thomas Drivsholm; Lars Berglund; Torben Hansen; Hans Lithell; Oluf Pedersen
Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians.
Diabetologia 2001;44(9):1170-6.
2001: Louise Torp Dalgaard; Torben Hansen; Søren A Urhammer; Thomas Drivsholm; Knut Borch-Johnsen; Oluf Pedersen
The uncoupling protein 3 -55 C -->T variant is not associated with Type II diabetes mellitus in Danish subjects.
Diabetologia 2001;44(8):1065-7.
2001: Lise Tarnow; Niels Grarup; Torben Hansen; Hans-Henrik Parving; Oluf Pedersen
Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(8):1653-6.
2001: AM Møller; N M Jensen; J Pildal; Thomas Drivsholm; Knut Borch-Johnsen; Søren A Urhammer; Torben Hansen; Oluf Pedersen
Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2001;86(5):2181-6.
2001: Louise Torp Dalgaard; Thorkild I A Sørensen; Thomas Drivsholm; Knut Borch-Johnsen; Teis Andersen; Torben Hansen; Oluf Pedersen
A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population.
The Journal of clinical endocrinology and metabolism 2001;86(3):1398-402.
2001: Lars Hansen; Jan N Jensen; Claus T Ekstrøm; Henrik Vestergaard; Torben Hansen; Oluf Pedersen
Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus.
Diabetologia 2001;44(2):237-40.
2001: Jan N Jensen; Lars Hansen; Claus T Ekstrøm; Flemming Pociot; J Nerup; Torben Hansen; Oluf Pedersen
Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population.
Diabetologia 2001;44(1):123-6.
2000: Søren A Urhammer; Torben Hansen; Knut Borch-Johnsen; Oluf Pedersen
Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects.
The Journal of clinical endocrinology and metabolism 2000;85(9):3151-4.
2000: Søren K Rasmussen; Søren A Urhammer; A Pizzuti; Søren M Echwald; Claus T Ekstrøm; Lars Hansen; Torben Hansen; Knut Borch-Johnsen; L Frittitta; V Trischitta; Oluf Pedersen
The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.
Diabetes 2000;49(9):1608-11.
2000: Søren K Rasmussen; Søren A Urhammer; Torben Hansen; Katrine Almind; AM Møller; Knut Borch-Johnsen; Oluf Pedersen
Variability of the insulin receptor substrate-1, hepatocyte nuclear factor-1alpha (HNF-1alpha), HNF-4alpha, and HNF-6 genes and size at birth in a population-based sample of young Danish subjects.
The Journal of clinical endocrinology and metabolism 2000;85(8):2951-3.
2000: L Hansen; Jan N Jensen; S Urioste; Helle Vestergaard Petersen; Flemming Pociot; Hans Eiberg; O P Kristiansen; Torben Hansen; Palle Serup; J Nerup; Oluf Pedersen
NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.
Diabetes 2000;49(5):876-8.
2000: Søren K Rasmussen; Søren A Urhammer; Jan N Jensen; Torben Hansen; Knut Borch-Johnsen; Oluf Pedersen
The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.
The Journal of clinical endocrinology and metabolism 2000;85(4):1731-4.
2000: Søren K Rasmussen; Corinne Lautier; Lars Hansen; Søren M Echwald; Torben Hansen; Claus T Ekstrøm; Søren A Urhammer; Knut Borch-Johnsen; FLORIN GRIGORESCU; R J Smith; Oluf Pedersen
Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2000;85(4):1606-10.
2000: L Hansen; S Urioste; Helle Vestergaard Petersen; Jan N Jensen; Hans Eiberg; F Barbetti; Palle Serup; Torben Hansen; Oluf Pedersen
Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in caucasians.
The Journal of clinical endocrinology and metabolism 2000;85(3):1323-6.
2000: Lars Hansen; R Reneland; Lars Berglund; Søren K Rasmussen; Torben Hansen; Hans Lithell; Oluf Pedersen
Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.
Diabetes 2000;49(2):298-301.
1999: Louise Torp Dalgaard; Thorkild I A Sørensen; Teis Andersen; Torben Hansen; Oluf Pedersen
An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men.
Diabetologia 1999;42(12):1413-6.
1999: Katrine Almind; S K Frederiksen; Dolores Bernal; Torben Hansen; Louise Ambye; Søren A Urhammer; C T Ekstrøm; Lars Berglund; R Reneland; H Lithell; Morris F White; Emmanuel Van Obberghen; Oluf Pedersen
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.
Diabetologia 1999;42(10):1244-9.
1999: AM Møller; Jakob Ek; S M Durviaux; Søren A Urhammer; JO Clausen; Hans Eiberg; Torben Hansen; G G Rousseau; Frédéric P Lemaigre; Oluf Pedersen
Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
Diabetologia 1999;42(8):1011-6.
1999: Katrine Almind; M G Ahlgren; Torben Hansen; Søren A Urhammer; JO Clausen; Oluf Pedersen
Discovery of a Met300Val variant in Shc and studies of its relationship to birth weight and length, impaired insulin secretion, insulin resistance, and type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1999;84(6):2241-4.
1999: Louise Torp Dalgaard; Torben Hansen; Søren A Urhammer; JO Clausen; Hans Eiberg; Oluf Pedersen
Intermediate expansions of a GAA repeat in the frataxin gene are not associated with type 2 diabetes or altered glucose-induced beta-cell function in Danish Caucasians.
Diabetes 1999;48(4):914-7.
1999: Lars Hansen; H Fjordvang; Søren K Rasmussen; Henrik Vestergaard; Søren M Echwald; Torben Hansen; D Alessi; Shirish Shenolikar; Alan Saltiel; F Barbetti; Oluf Pedersen
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
Diabetes 1999;48(2):403-7.
1999: AM Møller; Louise Torp Dalgaard; Louise Ambye; Lars Hansen; O Schmitz; Torben Hansen; Oluf Pedersen
A novel Phe75fsdelT mutation in the hepatocyte nuclear factor-4alpha gene in a Danish pedigree with maturity-onset diabetes of the young.
The Journal of clinical endocrinology and metabolism 1999;84(1):367-9.
1998: AM Møller; Louise Torp Dalgaard; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes.
Diabetologia 1998;41(12):1528-31.
1998: Søren A Urhammer; Torben Hansen; Claus T Ekstrøm; Hans Eiberg; Oluf Pedersen
The Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene contributes to the interindividual variation in serum C-peptide response during an oral glucose tolerance test: evidence from studies of 231 glucose-tolerant first degree relatives of type 2 diabetic probands.
The Journal of clinical endocrinology and metabolism 1998;83(12):4506-9.
1998: Søren A Urhammer; AM Møller; B Nyholm; Claus T Ekstrøm; Hans Eiberg; JO Clausen; Torben Hansen; Oluf Pedersen; O Schmitz
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 1998;83(11):3992-5.
1998: Katrine Almind; Louise Ambye; Søren A Urhammer; Torben Hansen; Søren M Echwald; J J Holst; J Gromada; B Thorens; Oluf Pedersen
Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.
Diabetologia 1998;41(10):1194-8.
1998: Katrine Almind; S K Frederiksen; M G Ahlgren; Søren A Urhammer; Torben Hansen; JO Clausen; Oluf Pedersen
Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance.
Diabetologia 1998;41(8):969-74.
1998: Søren A Urhammer; Torben Hansen; JO Clausen; Hans Eiberg; Oluf Pedersen
The g/a nucleotide variant at position -30 in the beta-cell-specific glucokinase gene promoter has no impact on the beta-cell function in Danish Caucasians.
Diabetes 1998;47(8):1359-61.
1998: Torben Hansen; Søren M Echwald; Lars Hansen; AM Møller; Katrine Almind; JO Clausen; Søren A Urhammer; H Inoue; Jorge Ferrer; J Bryan; Lydia Aguilar-Bryan; M Alan Permutt; Oluf Pedersen
Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.
Diabetes 1998;47(4):598-605.
1997: Søren A Urhammer; Louise Torp Dalgaard; Thorkild I A Sørensen; AM Møller; Teis Andersen; A Tybjaerg-Hansen; Torben Hansen; JO Clausen; Henrik Vestergaard; Oluf Pedersen
Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance.
Diabetologia 1997;40(10):1227-30.
1997: AM Møller; Søren A Urhammer; Louise Torp Dalgaard; R Reneland; Lars Berglund; Torben Hansen; JO Clausen; Hans Lithell; Oluf Pedersen
Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM.
Diabetologia 1997;40(8):980-3.
1997: Lars Hansen; K C Arden; S B Rasmussen; Carrie Viars; Henrik Vestergaard; Torben Hansen; AM Møller; J R Woodgett; Oluf Pedersen
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
Diabetologia 1997;40(8):940-6.
1997: Lars Hansen; Torben Hansen; JO Clausen; Søren M Echwald; Søren A Urhammer; Søren K Rasmussen; Oluf Pedersen
The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance.
American journal of human genetics 1997;60(6):1532-5.
1997: Søren A Urhammer; Torben Hansen; L B Jensen; JO Clausen; Lars Hansen; K C Chui; Oluf Pedersen
Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index.
The Journal of clinical endocrinology and metabolism 1997;82(6):1786-9.
1997: Søren A Urhammer; M Fridberg; Torben Hansen; Søren K Rasmussen; AM Møller; JO Clausen; Oluf Pedersen
A prevalent amino acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge.
Diabetes 1997;46(5):912-6.
1997: Søren A Urhammer; Søren K Rasmussen; P J Kaisaki; N Oda; K Yamagata; AM Møller; M Fridberg; Lars Hansen; Torben Hansen; Graeme I Bell; Oluf Pedersen
Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.
Diabetologia 1997;40(4):473-5.
1997: Torben Hansen; H Eiberg; M Rouard; Martine Vaxillaire; AM Møller; Søren K Rasmussen; M Fridberg; Søren A Urhammer; J J Holst; Katrine Almind; Søren M Echwald; Lars Hansen; Graeme I Bell; Oluf Pedersen
Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.
Diabetes 1997;46(4):726-30.
1997: Torben Hansen; C B Andersen; Søren M Echwald; Søren A Urhammer; JO Clausen; Henrik Vestergaard; D Owens; Lars Hansen; Oluf Pedersen
Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.
Diabetes 1997;46(3):494-501.
1996: K Yamagata; Naohisa Oda; Pamela J Kaisaki; Stephan Menzel; H Furuta; Martine Vaxillaire; L Southam; R D Cox; G Mark Lathrop; V V Boriraj; X Chen; Nancy J Cox; Y Oda; H Yano; Michelle M Le Beau; S Yamada; H Nishigori; J Takeda; SS Fajans; Andrew T Hattersley; Naoko Iwasaki; Torben Hansen; Oluf Pedersen; Kenneth S Polonsky; Graeme I Bell
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Nature 1996;384(6608):455-8.
1996: P Koefoed Theil; Torben Hansen; Michael Larsen; Oluf Pedersen; Henrik Lund-Andersen
Lens autofluorescence is increased in newly diagnosed patients with NIDDM.
Diabetologia 1996;39(12):1524-7.
1996: Søren A Urhammer; JO Clausen; Torben Hansen; Oluf Pedersen
Insulin sensitivity and body weight changes in young white carriers of the codon 64 amino acid polymorphism of the beta 3-adrenergic receptor gene.
Diabetes 1996;45(8):1115-20.
1995: Henrik Vestergaard; C Bjørbaek; Torben Hansen; F S Larsen; D K Granner; Oluf Pedersen
Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.
The Journal of clinical investigation 1995;96(6):2639-45.
1995: JO Clausen; Torben Hansen; C Bjørbaek; Søren M Echwald; Søren A Urhammer; S Rasmussen; C B Andersen; Lars Hansen; Katrine Almind; K Winther
Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.
Lancet 1995;346(8972):397-402.
1995: Lars Hansen; Torben Hansen; Henrik Vestergaard; C Bjørbaek; Søren M Echwald; JO Clausen; Y H Chen; M X Chen; P T Cohen; Oluf Pedersen
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.
Human molecular genetics 1995;4(8):1313-20.
1995: Henrik Vestergaard; H H Klein; Torben Hansen; J Müller; F Skovby; C Bjørbaek; ME Røder; Oluf Pedersen
Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy.
The Journal of clinical investigation 1995;95(4):1925-32.
1995: Søren M Echwald; C Bjørbaek; Torben Hansen; JO Clausen; Henrik Vestergaard; J R Zierath; R L Printz; D K Granner; Oluf Pedersen
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Diabetes 1995;44(3):347-53.
1995: C Bjørbaek; T A Vik; Søren M Echwald; P Y Yang; Henrik Vestergaard; J P Wang; G C Webb; K Richmond; Torben Hansen; R L Erikson
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
Diabetes 1995;44(1):90-7.
1994: Y H Chen; Lars Hansen; M X Chen; C Bjørbaek; Henrik Vestergaard; Torben Hansen; Patricia T W Cohen; Oluf Pedersen
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM.
Diabetes 1994;43(10):1234-41.
1994: C Bjørbaek; Søren M Echwald; P Hubricht; Henrik Vestergaard; Torben Hansen; J Zierath; Oluf Pedersen
Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM.
Diabetes 1994;43(8):976-83.
1993: Torben Hansen; C Bjørbaek; Henrik Vestergaard; K Grønskov; J F Bak; Oluf Pedersen
Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1993;77(6):1500-5.
1993: Katrine Almind; C Bjørbaek; Henrik Vestergaard; Torben Hansen; Søren M Echwald; Oluf Pedersen
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.
Lancet 1993;342(8875):828-32.