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Akiyoshi Hara

Research Profile

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Anatomy

Chemicals & Drugs

Physiology

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Publications

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Shuhko Kuriyama; Hitoshi Kashiwagi; Koh-ichi Yuhki; Fumiaki Kojima; Takehiro Yamada; Takayuki Fujino; Akiyoshi Hara; Koji Takayama; Takayuki Maruyama; Akitoshi Yoshida; Shuh Narumiya; Fumitaka Ushikubi
Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation.
Akiyoshi Hara; Koh-ichi Yuhki; Takayuki Fujino; Takehiro Yamada; Koji Takayama; Shuhko Kuriyama; Osamu Takahata; Hideji Karibe; Yuji Okada; Chun-Yang Xiao; Hong Ma; Shuh Narumiya; Fumitaka Ushikubi
Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor.
Koji Takayama; Koh-ichi Yuhki; Kyoichi Ono; Takayuki Fujino; Akiyoshi Hara; Takehiro Yamada; Shuhko Kuriyama; Hideji Karibe; Yuji Okada; Osamu Takahata; Takanobu Taniguchi; Toshihiko Iijima; Hiroshi Iwasaki; Shuh Narumiya; Fumitaka Ushikubi
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.

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All Publications

2010: Shuhko Kuriyama; Hitoshi Kashiwagi; Koh-ichi Yuhki; Fumiaki Kojima; Takehiro Yamada; Takayuki Fujino; Akiyoshi Hara; Koji Takayama; Takayuki Maruyama; Akitoshi Yoshida; Shuh Narumiya; Fumitaka Ushikubi
Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation.
Thrombosis and haemostasis 2010;104(4):796-803.
2005: Akiyoshi Hara; Koh-ichi Yuhki; Takayuki Fujino; Takehiro Yamada; Koji Takayama; Shuhko Kuriyama; Osamu Takahata; Hideji Karibe; Yuji Okada; Chun-Yang Xiao; Hong Ma; Shuh Narumiya; Fumitaka Ushikubi
Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor.
Circulation 2005;112(1):84-92.
2005: Koji Takayama; Koh-ichi Yuhki; Kyoichi Ono; Takayuki Fujino; Akiyoshi Hara; Takehiro Yamada; Shuhko Kuriyama; Hideji Karibe; Yuji Okada; Osamu Takahata; Takanobu Taniguchi; Toshihiko Iijima; Hiroshi Iwasaki; Shuh Narumiya; Fumitaka Ushikubi
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.
Nature medicine 2005;11(5):562-6.
2004: Takayuki Fujino; Naoki Nakagawa; Koh-ichi Yuhki; Akiyoshi Hara; Takehiro Yamada; Koji Takayama; Shuhko Kuriyama; Yayoi Hosoki; Osamu Takahata; Takanobu Taniguchi; Jun Fukuzawa; Naoyuki Hasebe; Kenjiro Kikuchi; Shuh Narumiya; Fumitaka Ushikubi
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.
The Journal of clinical investigation 2004;114(6):805-12.
2004: Chun-Yang Xiao; Koh-ichi Yuhki; Akiyoshi Hara; Takayuki Fujino; Shuhko Kuriyama; Takehiro Yamada; Koji Takayama; Osamu Takahata; Hideji Karibe; Takanobu Taniguchi; Shuh Narumiya; Fumitaka Ushikubi
Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4.
Circulation 2004;109(20):2462-8.
2003: Takehiro Yamada; Takayuki Fujino; Koh-ichi Yuhki; Akiyoshi Hara; Hideji Karibe; Osamu Takahata; Yuji Okada; Chun-Yang Xiao; Koji Takayama; Shuhko Kuriyama; Takanobu Taniguchi; Takahiro Shiokoshi; Yoshinobu Ohsaki; Kenjiro Kikuchi; Shuh Narumiya; Fumitaka Ushikubi
Thromboxane A2 regulates vascular tone via its inhibitory effect on the expression of inducible nitric oxide synthase.
Circulation 2003;108(19):2381-6.
2003: Akiyoshi Hara; Koh-ichi Yuhki; Takayuki Fujino; Shuh Narumiya; Fumitaka Ushikubi
[Pathophysiological roles of the prostanoids in the cardiovascular system: studies using mice deficient in prostanoid receptors].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(5):384-90.
2002: Takayuki Fujino; Koh-ichi Yuhki; Takehiro Yamada; Akiyoshi Hara; Osamu Takahata; Yuji Okada; Chun-Yang Xiao; Hong Ma; Hideji Karibe; Yasunori Iwashima; Jun Fukuzawa; Naoyuki Hasebe; Kenjiro Kikuchi; Shuh Narumiya; Fumitaka Ushikubi
Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells.
British journal of pharmacology 2002;136(4):530-9.
2001: Chun-Yang Xiao; Akiyoshi Hara; Koh-ichi Yuhki; Takayuki Fujino; Hong Ma; Yuji Okada; Osamu Takahata; Takehiro Yamada; T Murata; Shuh Narumiya; Fumitaka Ushikubi
Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors.
Circulation 2001;104(18):2210-5.
2001: Hong Ma; Akiyoshi Hara; Chun-Yang Xiao; Yuji Okada; Osamu Takahata; K Nakaya; Y Sugimoto; A Ichikawa; Shuh Narumiya; Fumitaka Ushikubi
Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3).
Circulation 2001;104(10):1176-80.
2000: Yuji Okada; Akiyoshi Hara; Hong Ma; Chun-Yang Xiao; Osamu Takahata; Y Kohgo; Shuh Narumiya; Fumitaka Ushikubi
Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors.
British journal of pharmacology 2000;131(4):745-55.
2000: K Maruyama; Akiyoshi Hara; H Hashizume; Fumitaka Ushikubi; Y Abiko
Ranolazine attenuates palmitoyl-L-carnitine-induced mechanical and metabolic derangement in the isolated, perfused rat heart.
The Journal of pharmacy and pharmacology 2000;52(6):709-15.
1999: Akiyoshi Hara; T Suzuki; H Hashizume; N Shishido; M Nakamura; F Ushikubi; Y Abiko
Effects of CP-060S, a novel Ca(2+) channel blocker, on oxidative stress in cultured cardiac myocytes.
European journal of pharmacology 1999;385(1):81-8.
1999: Akiyoshi Hara; J Arakawa; Chun-Yang Xiao; H Hashizume; Fumitaka Ushikubi; Y Abiko
Inhibition of Na+ channel or Na+/H+ exchanger attenuates the hydrogen peroxide-induced derangements in isolated perfused rat heart.
The Journal of pharmacy and pharmacology 1999;51(9):1049-58.
1999: Chun-Yang Xiao; Akiyoshi Hara; H Hashizume; K Tanaka; Y Abiko
Both D-cis- and L-cis-diltiazem attenuate hydrogen peroxide-induced derangements in rat hearts.
European journal of pharmacology 1999;374(3):387-98.
1999: Hong Ma; H Hashizume; Akiyoshi Hara; K Yazawa; Y Abiko
Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes.
Japanese journal of pharmacology 1999;79(1):17-24.
1998: H Matsumura; Akiyoshi Hara; H Hashizume; K Maruyama; Y Abiko
Protective effects of ranolazine, a novel anti-ischemic drug, on the hydrogen peroxide-induced derangements in isolated, perfused rat heart: comparison with dichloroacetate.
Japanese journal of pharmacology 1998;77(1):31-9.
1998: H Hashizume; M Chen; Hong Ma; Akiyoshi Hara; K Yazawa; M Akahira; Chun-Yang Xiao; Y Abiko
A new approach to the development of anti-ischemic drugs: protective drugs against cell injury induced by lysophosphatidylcholine.
Life sciences 1998;62(17-18):1695-9.
1998: M Akahira; Akiyoshi Hara; H Hashizume; M Nakamura; Y Abiko
Protective effect of prazosin on the hydrogen peroxide-induced derangements in the isolated perfused rat heart.
Life sciences 1998;62(19):1755-66.
1997: Chun-Yang Xiao; M Chen; Akiyoshi Hara; H Hashizume; Y Abiko
Palmitoyl-L-carnitine modifies the myocardial levels of high-energy phosphates and free fatty acids.
Basic research in cardiology 1997;92(5):320-30.
1997: Akiyoshi Hara; N Hayase; H Hashizume; Y Abiko
Protective effects of dilazep and its derivative K-7259 on the haemolysis induced by amphiphiles in rat erythrocytes.
The Journal of pharmacy and pharmacology 1997;49(8):806-11.
1997: Akiyoshi Hara; J Arakawa; H Hashizume; Y Abiko
Beneficial effects of dilazep on the palmitoyl-L-carnitine-induced derangements in isolated, perfused rat heart: comparison with tetrodotoxin.
Japanese journal of pharmacology 1997;74(2):147-53.
1997: A N Hoque; N Hoque; Akiyoshi Hara; H Hashizume; K Ichihara; Y Abiko
Cardioprotective effect of K-7259, a novel dilazep derivative, against ischemia-reperfusion damage in isolated, working rat hearts.
Japanese journal of pharmacology 1997;73(4):365-9.
1997: M Akahira; Akiyoshi Hara; Y Abiko
Effect of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on myocardial derangements induced by hydrogen peroxide in the isolated perfused rat heart.
Fundamental & clinical pharmacology 1997;11(4):356-64.
1997: H Hashizume; A N Hoque; K Magishi; Akiyoshi Hara; Y Abiko
A new approach to the development of anti-ischemic drugs. Substances that counteract the deleterious effect of lysophosphatidylcholine on the heart.
Japanese heart journal 1997;38(1):11-25.
1997: M Chen; H Hashizume; Chun-Yang Xiao; Akiyoshi Hara; Y Abiko
Lysophosphatidylcholine induces Ca2+-independent cellular injury attenuated by d-propranolol in rat cardiomyocytes.
Life sciences 1997;60(3):PL57-62.
1996: Y Abiko; H Hashizume; Akiyoshi Hara
[A new approach to the understanding of the mechanism of ischemia/reperfusion damage in the heart and the effects of anti-ischemic drugs].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1996;108(4):195-202.
1996: Akiyoshi Hara; H Hashizume; Y Abiko
Dilazep and its derivative, K-7259, attenuate mechanical derangement induced by palmitoyl-L-carnitine in the isolated, perfused rat heart.
The Journal of pharmacology and experimental therapeutics 1996;279(1):32-8.
1996: Akiyoshi Hara; Y Abiko
Protective effects of dilazep and its novel derivative, K-7259, on mechanical and metabolic derangements induced by hydrogen peroxide in the isolated perfused rat heart.
The Journal of pharmacology and experimental therapeutics 1996;277(2):565-71.
1995: Akiyoshi Hara; M Akahira; Y Abiko
Effect of K-7259, a novel derivative of dilazep, on cardiovascular actions of adenosine: comparison with dilazep.
Archives internationales de pharmacodynamie et de thérapie 1995;330(1):66-75.
1995: Akiyoshi Hara; Y Abiko
Protective effect of hypoxia on mechanical and metabolic changes induced by hydrogen peroxide in rat hearts.
The American journal of physiology 1995;268(2 Pt 2):H614-20.
1993: Akiyoshi Hara; H Matsumura; Y Abiko
Lidocaine attenuates both mechanical and metabolic changes induced by hydrogen peroxide in the rat heart.
The American journal of physiology 1993;265(5 Pt 2):H1478-85.
1990: Akiyoshi Hara; H Matsumura; Y Abiko
Beneficial effect of magnesium on the isolated perfused rat heart during reperfusion after ischaemia: comparison between pre-ischaemic and post-ischaemic administration of magnesium.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(1):100-6.
1990: H Matsumura; Akiyoshi Hara; Y Abiko
Effect of diltiazem on the oxymyoglobin level of myocardial cells in the isolated, perfused rat heart during hypoxia.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1990;4(3):719-22.
1989: Akiyoshi Hara; H Matsumura; Y Abiko
Effect of nisoldipine on the oxymyoglobin level of myocardial cells in hypoxic, perfused rat hearts.
Archives internationales de pharmacodynamie et de thérapie 1989;298():78-89.