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Hideaki Hara

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Junji Tanaka; Shoketsu Hitoe; Takashi Kadekaru; Kenjirou Ogawa; Hiroshi Shimoda; Hideaki Hara
Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light.
Tomohiro Nakanishi; Masamitsu Shimazawa; Sou Sugitani; Kazuhiro Tsuruma; Shunsuke Imai; Yuta Inokuchi; Takashi Kudo; Hideaki Hara
Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice.
Fumiya Ishizuka; Shinsuke Nakamura; Hiromi Ogishima; Masamitsu Shimazawa; Kazuhiro Tsuruma; Naofumi Umigai; Hideaki Hara
Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.

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2013: Junji Tanaka; Shoketsu Hitoe; Takashi Kadekaru; Kenjirou Ogawa; Hiroshi Shimoda; Hideaki Hara
Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light.
Food chemistry 2013;139(1-4):129-37.
2013: Tomohiro Nakanishi; Masamitsu Shimazawa; Sou Sugitani; Kazuhiro Tsuruma; Shunsuke Imai; Yuta Inokuchi; Takashi Kudo; Hideaki Hara
Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice.
Journal of neurochemistry 2013;125(1):111-24.
2013: Fumiya Ishizuka; Shinsuke Nakamura; Hiromi Ogishima; Masamitsu Shimazawa; Kazuhiro Tsuruma; Naofumi Umigai; Hideaki Hara
Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.
European journal of pharmacology 2013;703(1-3):1-10.
2013: Norihito Takano; Kazuhiro Tsuruma; Yuta Ohno; Masamitsu Shimazawa; Hideaki Hara
Bimatoprost protects retinal neuronal damage via Akt pathway.
European journal of pharmacology 2013;702(1-3):56-61.
2013: Hiroyoshi Kasai; Takashi Kurasawa; Masamitsu Shimazawa; Yuji Takahashi; Kazuhiro Tsuruma; Haruhisa Hirata; Tomoyo Imamura; Hideaki Hara
Effects of roscovitine, a cell cycling-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage.
Neuroscience letters 2013;535():95-9.
2013: Keisuke Mishiro; Masamitsu Shimazawa; Yukiya Suzuki; Kazuhiro Tsuruma; Mitsunori Ishiguro; Hideaki Hara
Tissue plasminogen activator prevents restoration of tight junction proteins through upregulation of angiopoietin-2.
Current neurovascular research 2013;10(1):39-48.
2013: Junji Tanaka; Kazuhiro Tsuruma; Masayuki Yoshikawa; Hisashi Matsuda; Seikou Nakamura; Tomohiro Nakanishi; Masamitsu Shimazawa; Hiroshi Shimoda; Hideaki Hara
Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo.
Life sciences 2013;92(1):17-25.
2013: Shinsuke Nakamura; Masamitsu Shimazawa; Sou Sugitani; Haruka Takizawa; Kazuhiro Tsuruma; Yuhei Hashimoto; Hideaki Hara
Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78.
PloS one 2013;8(3):e60517.
2012: Nobutaka Morimoto; Hiroko Namimatsu; Masamitsu Shimazawa; Junji Takeda; Kazuhiro Tsuruma; Akemichi Baba; Nobuaki Egashira; Michihiro Fujiwara; Yusuke Gotoh; Kazuhide Hayakawa; Ichiro Horie; Kyoji Horie; Takahiro Iwamoto; Katsunori Iwasaki; Takuya Iyoda; Satomi Kita; Issei Komuro; Toshio Matsuda; Kenichi Mishima; Hideaki Hara
Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice.
Biochemical and biophysical research communications 2012;429(3-4):186-90.
2012: Yoko Ono; Atsushi Oyagi; Masamitsu Shimazawa; Kazuhiro Tsuruma; Mitsue Ishisaka; Hideaki Hara
Imipramine protects mouse hippocampus against tunicamycin-induced cell death.
European journal of pharmacology 2012;696(1-3):83-8.
2012: Kazuhiro Tsuruma; Akiko Honda; Shunsuke Imai; Yuki Inoue; Jinyong Lee; Yuta Ohno; Masahiko Satoh; Hiroki Shimazaki; Masamitsu Shimazawa; Hideaki Hara
Metallothionein-III deficiency exacerbates light-induced retinal degeneration.
Investigative ophthalmology & visual science 2012;53(12):7896-903.
2012: Atsushi Oyagi; Hideaki Hara
Essential roles of heparin-binding epidermal growth factor-like growth factor in the brain.
CNS neuroscience & therapeutics 2012;18(10):803-10.
2012: Masamitsu Shimazawa; Kazuhiro Tsuruma; Makoto Aihara; Yasushi Ito; Akinori Miwa; Hideaki Hara
Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice.
Journal of neuroscience research 2012;90(10):1960-9.
2012: M Ishiguro; F Ishizuka; T Iwama; K Kawasaki; K Mishiro; Masamitsu Shimazawa; Y Suzuki; K Tsuruma; S Yoshimura; Y Egashira; I Ikegaki; Hideaki Hara
A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator.
Neuroscience 2012;220():302-12.
2012: Yuta Ohno; Masamitsu Shimazawa; Kazuhiro Tsuruma; Naofumi Umigai; Tomohiro Nakanishi; Hideaki Hara
Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice.
European journal of pharmacology 2012;690(1-3):84-9.
2012: Kenta Murata; Atsushi Oyagi; Masamitsu Shimazawa; Dai Takahira; Kazuhiro Tsuruma; Takashi Ishibashi; Hideaki Hara
Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models.
Phytotherapy research : PTR 2012;26(8):1126-32.
2012: Yusuke Egashira; Toru Iwama; Keisuke Mishiro; Masamitsu Shimazawa; Sou Sugitani; Yukiya Suzuki; Kazuhiro Tsuruma; Shinichi Yoshimura; Hideaki Hara
The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model.
Brain research 2012;1461():87-95.
2012: Kazuhiro Tsuruma; Mika Yamauchi; Munekazu Iinuma; Ken-Ichi Nakashima; Hiroki Shimazaki; Masamitsu Shimazawa; Sou Sugitani; Hideaki Hara
Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo.
Molecular nutrition & food research 2012;56(5):713-24.
2012: Naofumi Umigai; Masamitsu Shimazawa; Junji Tanaka; Kazuhiro Tsuruma; Hideaki Hara
Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation.
Current neurovascular research 2012;9(2):102-9.
2012: K Mishiro; Masamitsu Shimazawa; Y Suzuki; K Tsuruma; M Ishiguro; Hideaki Hara
A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice.
Neuroscience 2012;205():39-48.
2012: Junji Tanaka; Kazuhiro Tsuruma; Shinsuke Nakamura; Masamitsu Shimazawa; Hiroshi Shimoda; Hideaki Hara
Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis.
Phytotherapy research : PTR 2012;26(2):214-22.
2012: Yukiya Suzuki; Hiroyuki Tanaka; Kazuhiro Tsuruma; Shinichi Yoshimura; Yusuke Egashira; Junya Hamanaka; Kozo Hattori; Yoshinobu Hirose; Naoki Inagaki; Mitsunori Ishiguro; Toru Iwama; Keisuke Mishiro; Tetsuji Murase; Hideko Nagasawa; Masamitsu Shimazawa; Hideaki Hara
Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia.
Scientific reports 2012;2():896.
2012: Yasushi Ito; Chihiro Mayama; Hirotaka Onoe; Masamitsu Shimazawa; Kazuhiro Tsuruma; Makoto Aihara; Makoto Araie; Kiyoshi Ishii; Hideaki Hara
Induction of amyloid-β(1-42) in the retina and optic nerve head of chronic ocular hypertensive monkeys.
Molecular vision 2012;18():2647-57.
2012: Mamoru Kakino; Masamitsu Shimazawa; Kazuhiro Tsuruma; Yoko Araki; Kenji Ichihara; Hiroshi Izuta; Hideaki Hara
Laxative effects and mechanism of action of Brazilian green propolis.
BMC complementary and alternative medicine 2012;12():192.
2012: Kazuhiro Tsuruma; Seiya Kishi; Yuhei Nishimura; Masamitsu Shimazawa; Toshio Tanaka; Hideaki Hara
SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells.
Investigative ophthalmology & visual science 2012;53(10):6729-37.
2012: Tetsuro Ito; Mamoru Kakino; Hiroe Maruyama; Masayoshi Oyama; Shigemi Tazawa; Tatsuya Watarai; Yoko Araki; Hideaki Hara; Munekazu Iinuma
Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves.
Journal of nutritional science and vitaminology 2012;58(2):136-42.
2012: Mitsue Ishisaka; Kenichi Kakefuda; Kiyoyuki Kitaichi; Yoko Ono; Atsushi Oyagi; Masamitsu Shimazawa; Kazuhiro Tsuruma; Hideaki Hara
Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity.
PloS one 2012;7(5):e37058.
2012: Kazuhiro Tsuruma; Mika Yamauchi; Yuta Inokuchi; Masamitsu Shimazawa; Sou Sugitani; Hideaki Hara
Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.
Journal of pharmacological sciences 2012;118(3):351-62.
2012: Shinsuke Nakamura; Hiromi Ogishima; Masamitsu Shimazawa; Kazuhiro Tsuruma; Shunsuke Imai; Hideaki Hara
Morphological and functional changes in the retina after chronic oxygen-induced retinopathy.
PloS one 2012;7(2):e32167.
2012: Masamitsu Shimazawa; Tetsuya Suhara; Yasuyoshi Watanabe; Hajime Yamanaka; Makoto Araie; Takuya Hayashi; Makoto Higuchi; Kazuyuki Imamura; Yuta Inokuchi; Yasushi Ito; Bin Ji; Tomohiro Nakanishi; Hirotaka Onoe; Hideaki Hara
An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: in vivo positron emission tomography imaging of glial activation.
PloS one 2012;7(1):e30526.
2011: Rumi Uchibayashi; Yuta Inokuchi; Masamitsu Shimazawa; Kazuhiro Tsuruma; Hideaki Hara
Involvement of Bid and caspase-2 in endoplasmic reticulum stress- and oxidative stress-induced retinal ganglion cell death.
Journal of neuroscience research 2011;89(11):1783-94.
2011: Atsushi Oyagi; Masamitsu Shimazawa; Kazuhiro Tsuruma; Kohji Fukunaga; Shigeki Moriguchi; Kenta Murata; Atsumi Nitta; Y Oida; Hideaki Hara
Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation.
Brain research 2011;1419():97-104.
2011: Hirotaka Tanaka; Kazuhiro Tsuruma; Hiroshi Izuta; Masataka Kimura; Hiroki Shimazaki; Masamitsu Shimazawa; Hideaki Hara
Apoptosis-inducing factor and cyclophilin A cotranslocate to the motor neuronal nuclei in amyotrophic lateral sclerosis model mice.
CNS neuroscience & therapeutics 2011;17(5):294-304.
2011: Hiroki Shimazaki; Masamitsu Shimazawa; Hirofumi Takeuchi; Yuichi Tozuka; Kazuhiro Tsuruma; Takuya Fujisawa; Kohei Hironaka; Hideaki Hara
Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.
Investigative ophthalmology & visual science 2011;52(10):7289-97.
2011: Etsuko Hayashi; Mine Kinoshita; Tomohiro Kobayashi; Kazuyoshi Kuratani; Yasuteru Shiroshita; Hideaki Hara
An automated evaluation system for analyzing antinociceptive effects on intracolonic capsaicin-induced visceral pain-related licking behavior in mice.
Journal of pharmacological and toxicological methods 2011;64(2):119-23.
2011: Kohei Hironaka; Yuta Inokuchi; Hiroki Shimazaki; Masamitsu Shimazawa; Mai Akane; Takuya Fujisawa; Hideaki Hara; Yuichi Tozuka; Kazuhiro Tsuruma; Hirofumi Takeuchi
Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;79(1):119-25.
2011: Kenjirou Ogawa; Atsushi Oyagi; Junji Tanaka; Saori Kobayashi; Hideaki Hara
The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice.
Phytotherapy research : PTR 2011;25(8):1160-5.
2011: Akihiro Koumura; Masamitsu Shimazawa; Kazuhiro Tsuruma; Junya Hamanaka; Isao Hozumi; Takashi Inuzuka; Koh Kawasaki; Hideaki Hara
Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.
The Journal of pharmacology and experimental therapeutics 2011;338(1):337-44.
2011: A Oyagi; Nobutaka Morimoto; J Hamanaka; M Ishiguro; K Tsuruma; Masamitsu Shimazawa; Hideaki Hara
Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury.
Neuroscience 2011;185():116-24.
2011: Junya Hamanaka; Hideaki Hara
Involvement of Toll-like receptors in ischemia-induced neuronal damage.
Central nervous system agents in medicinal chemistry 2011;11(2):107-13.
2011: Hideaki Hara; Yosuke Takasu; Yoshifumi Yamaoka; John M Doyle; Yoshiro Takahashi
Quantum degenerate mixtures of alkali and alkaline-earth-like atoms.
Physical review letters 2011;106(20):205304.
2011: Shinsuke Nakamura; Nobutaka Morimoto; Kazuhiro Tsuruma; Hiroshi Izuta; Yoshika Yasuda; Noriaki Kato; Tsunehiko Ikeda; Masamitsu Shimazawa; Hideaki Hara
Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(5):1041-8.
2011: Mitsunori Ishiguro; Hideaki Hara
[Protective effects of cilostazol against transient focal cerebral ischemia and hemorrhagic transformation].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2011;131(4):513-21.
2011: Yasushi Ito; Masamitsu Shimazawa; Yuta Inokuchi; Hajime Yamanaka; Kazuhiro Tsuruma; Kazuyuki Imamura; Hirotaka Onoe; Yasuyoshi Watanabe; Makoto Aihara; Makoto Araie; Hideaki Hara
Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model.
The European journal of neuroscience 2011;33(5):843-55.
2011: Etsuko Hayashi; Midori Shimamura; Kazuyoshi Kuratani; Mine Kinoshita; Hideaki Hara
Automated experimental system capturing three behavioral components during murine forced swim test.
Life sciences 2011;88(9-10):411-7.
2011: Shinsuke Nakamura; Kei Hayashi; Haruka Takizawa; Tetsuji Murase; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hiroki Kakuta; Hideko Nagasawa; Hideaki Hara
An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization.
Current neurovascular research 2011;8(1):25-34.
2011: Junji Tanaka; Tomohiro Nakanishi; Kenjirou Ogawa; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hiroshi Shimoda; Hideaki Hara
Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo.
Journal of agricultural and food chemistry 2011;59(2):528-36.
2011: Mai Akane; Masamitsu Shimazawa; Yuta Inokuchi; Kazuhiro Tsuruma; Hideaki Hara
SUN N8075, a novel radical scavenger, protects against retinal cell death in mice.
Neuroscience letters 2011;488(1):87-91.
2011: Mika Yamauchi; Kazuhiro Tsuruma; Shunsuke Imai; Tomohiro Nakanishi; Naofumi Umigai; Masamitsu Shimazawa; Hideaki Hara
Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity.
European journal of pharmacology 2011;650(1):110-9.
2011: Mitsue Ishisaka; Kenichi Kakefuda; Masamitsu Shimazawa; Kazuhiro Tsuruma; Akifumi Tsuruta; Mika Yamauchi; Hideaki Hara
Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress.
Biological & pharmaceutical bulletin 2011;34(9):1481-6.
2011: Kohei Hironaka; Takuya Fujisawa; Hitoshi Sasaki; Yuichi Tozuka; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hideaki Hara; Hirofumi Takeuchi
Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops.
Biological & pharmaceutical bulletin 2011;34(6):894-7.
2011: Masamitsu Shimazawa; Hideaki Hara
Novel situations of endothelial injury in stroke--mechanisms of stroke and strategy of drug development: protective effects of antiplatelet agents against stroke.
Journal of pharmacological sciences 2011;116(1):30-5.
2011: Yasushi Nishioka; Atsushi Oyagi; Kazuhiro Tsuruma; Masamitsu Shimazawa; Takashi Ishibashi; Hideaki Hara
The antianxiety-like effect of astaxanthin extracted from Paracoccus carotinifaciens.
BioFactors (Oxford, England) 2011;37(1):25-30.
2010: Shunsuke Imai; Masamitsu Shimazawa; Tomohiro Nakanishi; Kazuhiro Tsuruma; Hideaki Hara
Calpain inhibitor protects cells against light-induced retinal degeneration.
The Journal of pharmacology and experimental therapeutics 2010;335(3):645-52.
2010: K Hyakkoku; J Hamanaka; K Tsuruma; Masamitsu Shimazawa; H Tanaka; S Uematsu; S Akira; N Inagaki; H Nagai; Hideaki Hara
Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.
Neuroscience 2010;171(1):258-67.
2010: Hideaki Hara
Involvement of endoplasmic reticulum stress in pathogenesis after cerebral ischemia.
Rinshō shinkeigaku = Clinical neurology 2010;50(11):881.
2010: Akiko Honda; Hiroaki Komuro; Akinori Shimada; Tatsuya Hasegawa; Yoshiyuki Seko; Hisamitsu Nagase; Isao Hozumi; Takashi Inuzuka; Hideaki Hara; Yasuyuki Fujiwara; Masahiko Satoh
Attenuation of cadmium-induced testicular injury in metallothionein-III null mice.
Life sciences 2010;87(17-18):545-50.
2010: Y Oida; Junya Hamanaka; Kana Hyakkoku; Masamitsu Shimazawa; Takashi Kudo; Kazunori Imaizumi; Tadashi Yasuda; Hideaki Hara
Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice.
Neuroscience letters 2010;484(1):43-6.
2010: Yasushi Ito; Masamitsu Shimazawa; Hideaki Hara
REVIEW: An approach for neuroprotective therapies of secondary brain damage after excitotoxic retinal injury in mice.
CNS neuroscience & therapeutics 2010;16(5):e169-79.
2010: Shunsuke Imai; Yuta Inokuchi; Shinsuke Nakamura; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hideaki Hara
Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.
European journal of pharmacology 2010;642(1-3):77-85.
2010: Kazuhiro Tsuruma; Yuka Tanaka; Masamitsu Shimazawa; Hideaki Hara
Induction of amyloid precursor protein by the neurotoxic peptide, amyloid-beta 25-35, causes retinal ganglion cell death.
Journal of neurochemistry 2010;113(6):1545-54.
2010: Yuta Inokuchi; Kohei Hironaka; Takuya Fujisawa; Yuichi Tozuka; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hirofumi Takeuchi; Hideaki Hara
Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration.
Investigative ophthalmology & visual science 2010;51(6):3162-70.
2010: Yuichi Chikaraishi; Hiroshi Izuta; Masamitsu Shimazawa; Satoshi Mishima; Hideaki Hara
Angiostatic effects of Brazilian green propolis and its chemical constituents.
Molecular nutrition & food research 2010;54(4):566-75.
2010: Yasushi Ito; Shinsuke Nakamura; Hirotaka Tanaka; Kazuhiro Tsuruma; Masamitsu Shimazawa; Makoto Araie; Hideaki Hara
Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice.
CNS neuroscience & therapeutics 2010;16(2):103-14.
2010: Nozomu Matsunaga; Yuichi Chikaraishi; Masamitsu Shimazawa; Shigeru Yokota; Hideaki Hara
Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo.
Evidence-based complementary and alternative medicine : eCAM 2010;7(1):47-56.
2010: Masamitsu Shimazawa; Shinsuke Suemori; Yuta Inokuchi; Nozomu Matsunaga; Yoshimi Nakajima; Takayuki Oka; Tetsuya Yamamoto; Hideaki Hara
A novel calpain inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2010;332(2):380-7.
2010: Mitsunori Ishiguro; Keisuke Mishiro; Yasuyuki Fujiwara; Huayue Chen; Hiroshi Izuta; Kazuhiro Tsuruma; Masamitsu Shimazawa; Shinichi Yoshimura; Masahiko Satoh; Toru Iwama; Hideaki Hara
Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA.
PloS one 2010;5(12):e15178.
2010: Masamitsu Shimazawa; Hirotaka Tanaka; Yasushi Ito; Nobutaka Morimoto; Kazuhiro Tsuruma; Michinori Kadokura; Shigeki Tamura; Teruyoshi Inoue; Mitsunori Yamada; Hitoshi Takahashi; Hitoshi Warita; Masashi Aoki; Hideaki Hara
An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.
PloS one 2010;5(12):e15307.
2010: Kana Hyakkoku; Junya Hamanaka; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hideaki Hara
Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice.
Experimental & translational stroke medicine 2010;2(1):20.
2010: Mamoru Kakino; Shigemi Tazawa; Hiroe Maruyama; Kazuhiro Tsuruma; Yoko Araki; Masamitsu Shimazawa; Hideaki Hara
Laxative effects of agarwood on low-fiber diet-induced constipation in rats.
BMC complementary and alternative medicine 2010;10():68.
2010: Kenichi Kakefuda; Atsushi Oyagi; Mitsue Ishisaka; Kazuhiro Tsuruma; Masamitsu Shimazawa; Koichi Yokota; Yasuhito Shirai; Kyoji Horie; Naoaki Saito; Junji Takeda; Hideaki Hara
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
PloS one 2010;5(10):e13447.
2010: Atsushi Oyagi; Kenjirou Ogawa; Mamoru Kakino; Hideaki Hara
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice.
BMC complementary and alternative medicine 2010;10():45.
2010: Mamoru Kakino; Hiroshi Izuta; Tetsuro Ito; Kazuhiro Tsuruma; Yoko Araki; Masamitsu Shimazawa; Masayoshi Oyama; Munekazu Iinuma; Hideaki Hara
Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice.
Bioscience, biotechnology, and biochemistry 2010;74(8):1550-5.
2010: Hiroe Maruyama; Takashi Sakamoto; Yoko Araki; Hideaki Hara
Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema.
BMC complementary and alternative medicine 2010;10():30.
2010: Hiroshi Izuta; Nozomu Matsunaga; Masamitsu Shimazawa; Tetsuya Sugiyama; Tsunehiko Ikeda; Hideaki Hara
Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body.
Molecular vision 2010;16():130-6.
2010: Shinsuke Nakamura; Yuichi Chikaraishi; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hideaki Hara
Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
Experimental eye research 2010;90(1):137-45.
2010: Nozomu Matsunaga; Kazuhiro Tsuruma; Masamitsu Shimazawa; Shigeru Yokota; Hideaki Hara
Inhibitory actions of bilberry anthocyanidins on angiogenesis.
Phytotherapy research : PTR 2010;24 Suppl 1():S42-7.
2009: Akihiro Koumura; Kenichi Kakefuda; Akiko Honda; Yasushi Ito; Kazuhiro Tsuruma; Masamitsu Shimazawa; Yoko Uchida; Isao Hozumi; Masahiko Satoh; Takashi Inuzuka; Hideaki Hara
Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors.
Neuroscience letters 2009;467(1):11-4.
2009: Hiroshi Izuta; Yukimi Narahara; Masamitsu Shimazawa; Satoshi Mishima; Shin-ichi Kondo; Hideaki Hara
1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of bee products and their constituents determined by ESR.
Biological & pharmaceutical bulletin 2009;32(12):1947-51.
2009: Yasushi Ito; Mitsunori Yamada; Hirotaka Tanaka; Kazunari Aida; Kazuhiro Tsuruma; Masamitsu Shimazawa; Isao Hozumi; Takashi Inuzuka; Hitoshi Takahashi; Hideaki Hara
Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice.
Neurobiology of disease 2009;36(3):470-6.
2009: Hiroshi Izuta; Yuichi Chikaraishi; Masamitsu Shimazawa; Satoshi Mishima; Hideaki Hara
10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells.
Evidence-based complementary and alternative medicine : eCAM 2009;6(4):489-94.
2009: Akihiro Koumura; Junya Hamanaka; Masamitsu Shimazawa; Akiko Honda; Kazuhiro Tsuruma; Yoko Uchida; Isao Hozumi; Masahiko Satoh; Takashi Inuzuka; Hideaki Hara
Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia.
Brain research 2009;1292():148-54.
2009: Kenichi Kakefuda; Yasunori Fujita; Atsushi Oyagi; Kana Hyakkoku; Toshio Kojima; Ken Umemura; Kazuhiro Tsuruma; Masamitsu Shimazawa; Masafumi Ito; Yoshinori Nozawa; Hideaki Hara
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
Biochemical and biophysical research communications 2009;387(4):784-8.
2009: Yoshimi Nakajima; Masamitsu Shimazawa; Satoshi Mishima; Hideaki Hara
Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis.
Phytotherapy research : PTR 2009;23(10):1431-8.
2009: Yuichi Chikaraishi; Masamitsu Shimazawa; Koichi Yokota; Koichiro Yoshino; Hideaki Hara
CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo.
Current neurovascular research 2009;6(3):140-7.
2009: Yasushi Ito; Masamitsu Shimazawa; Yi-Ning Chen; Kazuhiro Tsuruma; Tetsumori Yamashima; Makoto Araie; Hideaki Hara
Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys.
Experimental eye research 2009;89(2):246-55.
2009: Nozomu Matsunaga; Shunsuke Imai; Yuta Inokuchi; Masamitsu Shimazawa; Shigeru Yokota; Yoko Araki; Hideaki Hara
Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.
Molecular nutrition & food research 2009;53(7):869-77.
2009: Yuko Nonaka; Akihiro Koumura; Kana Hyakkoku; Masamitsu Shimazawa; Shinichi Yoshimura; Toru Iwama; Hideaki Hara
Combination treatment with normobaric hyperoxia and cilostazol protects mice against focal cerebral ischemia-induced neuronal damage better than each treatment alone.
The Journal of pharmacology and experimental therapeutics 2009;330(1):13-22.
2009: Yuta Inokuchi; Shunsuke Imai; Yoshimi Nakajima; Masamitsu Shimazawa; Makoto Aihara; Makoto Araie; Hideaki Hara
Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2009;329(2):687-98.
2009: Yoshimi Nakajima; Masamitsu Shimazawa; Kazumasa Otsubo; Takashi Ishibashi; Hideaki Hara
Zeaxanthin, a retinal carotenoid, protects retinal cells against oxidative stress.
Current eye research 2009;34(4):311-8.
2009: K Hyakkoku; Y Nakajima; H Izuta; Masamitsu Shimazawa; T Yamamoto; N Shibata; Hideaki Hara
Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice.
Neuroscience 2009;159(2):760-9.
2009: Yuko Nonaka; Kazuhiro Tsuruma; Masamitsu Shimazawa; Shinichi Yoshimura; Toru Iwama; Hideaki Hara
Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage.
Neuroscience letters 2009;452(2):156-61.
2009: Y Inokuchi; Masamitsu Shimazawa; Y Nakajima; I Komuro; T Matsuda; A Baba; Makoto Araie; S Kita; T Iwamoto; Hideaki Hara
A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion.
Journal of neuroscience research 2009;87(4):906-17.
2009: Masamitsu Shimazawa; Yoshimi Nakajima; Yukihiko Mashima; Hideaki Hara
Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells.
Brain research 2009;1251():269-75.
2009: Hiroshi Izuta; Yuichi Chikaraishi; Tetsuo Adachi; Masamitsu Shimazawa; Tetsuya Sugiyama; Tsunehiko Ikeda; Hideaki Hara
Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients.
Molecular vision 2009;15():2663-72.
2009: Hiroshi Izuta; Masamitsu Shimazawa; Kazuhiro Tsuruma; Yoko Araki; Satoshi Mishima; Hideaki Hara
Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells.
BMC complementary and alternative medicine 2009;9():45.
2009: Atsushi Oyagi; Y Oida; Kenichi Kakefuda; Masamitsu Shimazawa; Norifumi Shioda; Shigeki Moriguchi; Kiyoyuki Kitaichi; Daisuke Nanba; Kazumasa Yamaguchi; Yasuhide Furuta; Kohji Fukunaga; Shigeki Higashiyama; Hideaki Hara
Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.
PloS one 2009;4(10):e7461.
2009: Yoshimi Nakajima; Kazuhiro Tsuruma; Masamitsu Shimazawa; Satoshi Mishima; Hideaki Hara
Comparison of bee products based on assays of antioxidant capacities.
BMC complementary and alternative medicine 2009;9():4.
2009: Yuta Inokuchi; Yoshimi Nakajima; Masamitsu Shimazawa; Takanori Kurita; Mikiko Kubo; Atsushi Saito; Hironao Sajiki; Takashi Kudo; Makoto Aihara; Kazunori Imaizumi; Makoto Araie; Hideaki Hara
Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.
Investigative ophthalmology & visual science 2009;50(1):334-44.
2008: A Koumura; Y Nonaka; K Hyakkoku; T Oka; Masamitsu Shimazawa; Isao Hozumi; Takashi Inuzuka; Hideaki Hara
A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice.
Neuroscience 2008;157(2):309-18.
2008: Nozomu Matsunaga; Yuichi Chikaraishi; Hiroshi Izuta; Nahoko Ogata; Masamitsu Shimazawa; Miyo Matsumura; Hideaki Hara
Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy.
Ophthalmology 2008;115(11):1916-22.
2008: Hiroshi Izuta; Masamitsu Shimazawa; Shigemi Tazawa; Yoko Araki; Satoshi Mishima; Hideaki Hara
Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.
Journal of agricultural and food chemistry 2008;56(19):8944-53.
2008: Yoshimi Nakajima; Yuta Inokuchi; Masamitsu Shimazawa; Kazumasa Otsubo; Takashi Ishibashi; Hideaki Hara
Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.
The Journal of pharmacy and pharmacology 2008;60(10):1365-74.
2008: Yuko Nonaka; Masamitsu Shimazawa; Shinichi Yoshimura; Toru Iwama; Hideaki Hara
Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice.
Neuroscience letters 2008;441(2):224-8.
2008: Yoshimi Nakajima; Yuta Inokuchi; Masahiro Nishi; Masamitsu Shimazawa; Kazumasa Otsubo; Hideaki Hara
Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo.
Brain research 2008;1226():226-33.
2008: A Oyagi; Y Oida; Hideaki Hara; H Izuta; Masamitsu Shimazawa; N Matsunaga; T Adachi; H Hara
Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease.
Brain research 2008;1214():169-76.
2008: Yasushi Ito; Masamitsu Shimazawa; Yuta Inokuchi; Hidefumi Fukumitsu; Syouei Furukawa; Makoto Araie; Hideaki Hara
Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice.
Brain research 2008;1212():89-101.
2008: Y Oida; H Izuta; A Oyagi; Masamitsu Shimazawa; T Kudo; K Imaizumi; Hideaki Hara
Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil.
Brain research 2008;1208():217-24.
2008: Hideaki Hara; Yasuaki Ise; Nobutaka Morimoto; Masamitsu Shimazawa; Koji Ichihashi; Masayoshi Ohyama; Munekazu Iinuma
Laxative effect of agarwood leaves and its mechanism.
Bioscience, biotechnology, and biochemistry 2008;72(2):335-45.
2008: Yoshinori Kotani; Yoshimi Nakajima; Tatsuya Hasegawa; Masahiko Satoh; Hisamitsu Nagase; Masamitsu Shimazawa; Shinichi Yoshimura; Toru Iwama; Hideaki Hara
Propofol exerts greater neuroprotection with disodium edetate than without it.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):354-66.
2008: Y Oida; Masamitsu Shimazawa; K Imaizumi; Hideaki Hara
Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil.
Neuroscience 2008;151(1):111-9.
2008: Yasushi Ito; Shinsuke Nakamura; Hirotaka Tanaka; Masamitsu Shimazawa; Makoto Araie; Hideaki Hara
Memantine protects against secondary neuronal degeneration in lateral geniculate nucleus and superior colliculus after retinal damage in mice.
CNS neuroscience & therapeutics 2008;14(3):192-202.
2008: Yoshinori Kotani; Masamitsu Shimazawa; Shinichi Yoshimura; Toru Iwama; Hideaki Hara
The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties.
CNS neuroscience & therapeutics 2008;14(2):95-106.
2008: Nozomu Matsunaga; Masamitsu Shimazawa; Kazumasa Otsubo; Hideaki Hara
Phosphatidylinositol inhibits vascular endothelial growth factor-A--induced migration of human umbilical vein endothelial cells.
Journal of pharmacological sciences 2008;106(1):128-35.
2008: Yuichi Chikaraishi; Nozomu Matsunaga; Masamitsu Shimazawa; Hideaki Hara
Rifampicin inhibits the retinal neovascularization in vitro and in vivo.
Experimental eye research 2008;86(1):131-7.
2007: Y Kotani; Nobutaka Morimoto; Y Oida; Y Tamura; S Tamura; T Inoue; Masamitsu Shimazawa; S Yoshimura; T Iwama; Hideaki Hara
Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properties.
Neuroscience 2007;149(4):779-88.
2007: Kazuhiro Irie; Kazuma Murakami; Y Masuda; Akira Morimoto; Hajime Ohigashi; Hideaki Hara; Ryutaro Ohashi; Kiyonori Takegoshi; H Fukuda; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease.
Mini reviews in medicinal chemistry 2007;7(10):1001-8.
2007: Kenji Wakida; Masamitsu Shimazawa; Isao Hozumi; Masahiko Satoh; Hisamitsu Nagase; Takashi Inuzuka; Hideaki Hara
Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia.
Neuroscience 2007;148(1):105-14.
2007: Masamitsu Shimazawa; Yasushi Ito; Yuta Inokuchi; Hideaki Hara
Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.
Investigative ophthalmology & visual science 2007;48(8):3729-36.
2007: Nobutaka Morimoto; Y Oida; Masamitsu Shimazawa; M Miura; T Kudo; K Imaizumi; Hideaki Hara
Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice.
Neuroscience 2007;147(4):957-67.
2007: Kentaro Yamashita; Yoshinori Kotani; Yoshimi Nakajima; Masamitsu Shimazawa; Shin-ichi Yoshimura; Shigeru Nakashima; Toru Iwama; Hideaki Hara
Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.
Brain research 2007;1154():215-24.
2007: Yuichi Chikaraishi; Masamitsu Shimazawa; Hideaki Hara
[Evaluation system to search for inhibitory effect of retinal neovascularization in vitro and in vivo].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2007;129(6):451-6.
2007: Masamitsu Shimazawa; Yuta Inokuchi; Yasushi Ito; Hideaki Hara
[Experimental techniques for animal models of retinal diseases in mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2007;129(6):445-50.
2007: Yuichi Chikaraishi; Masamitsu Shimazawa; Hideaki Hara
New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice.
Experimental eye research 2007;84(3):529-36.
2007: Yoshimi Nakajima; Masamitsu Shimazawa; Satoshi Mishima; Hideaki Hara
Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions.
Life sciences 2007;80(4):370-7.
2007: Yasushi Ito; Yukihiro Akao; Masamitsu Shimazawa; Norio Seki; Yoshinori Nozawa; Hideaki Hara
Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.
CNS drug reviews 2007;13(3):296-307.
2007: Masamitsu Shimazawa; Yuta Inokuchi; Yasushi Ito; Hiroshi Murata; Makoto Aihara; Masayuki Miura; Makoto Araie; Hideaki Hara
Involvement of ER stress in retinal cell death.
Molecular vision 2007;13():578-87.
2006: Masamitsu Shimazawa; Hideaki Hara
Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress.
Neuroscience letters 2006;409(3):192-5.
2006: Kenji Wakida; Nobutaka Morimoto; Masamitsu Shimazawa; Isao Hozumi; Hisamitsu Nagase; Takashi Inuzuka; Hideaki Hara
Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2.
Brain research 2006;1116(1):187-93.
2006: Yasushi Ito; Masamitsu Shimazawa; Yukihiro Akao; Yoshimi Nakajima; Norio Seki; Yoshinori Nozawa; Hideaki Hara
Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.
Journal of pharmacological sciences 2006;102(2):196-204.
2006: Shinsuke Suemori; Masamitsu Shimazawa; Kazuhide Kawase; Masahiko Satoh; Hisamitsu Nagase; Tetsuya Yamamoto; Hideaki Hara
Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice.
Investigative ophthalmology & visual science 2006;47(9):3975-82.
2006: M Sasaoka; Takazumi Taniguchi; Masamitsu Shimazawa; Naruhiro Ishida; Atsushi Shimazaki; Hideaki Hara
Intravitreal injection of endothelin-1 caused optic nerve damage following to ocular hypoperfusion in rabbits.
Experimental eye research 2006;83(3):629-37.
2006: Takazumi Taniguchi; Masamitsu Shimazawa; M Sasaoka; Atsushi Shimazaki; Hideaki Hara
Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve.
Current neurovascular research 2006;3(2):81-8.
2006: Kazuhiro Tsuruma; Tadashi Nakagawa; Nobutaka Morimoto; Masabumi Minami; Hideaki Hara; Takashi Uehara; Yasuyuki Nomura
Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.
The Journal of biological chemistry 2006;281(16):11397-404.
2006: Y Oida; K Kitaichi; H Nakayama; Y Ito; Y Fujimoto; Masamitsu Shimazawa; H Nagai; Hideaki Hara
Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain.
Brain research 2006;1082(1):196-204.
2006: Yuta Inokuchi; Masamitsu Shimazawa; Yoshimi Nakajima; Shinsuke Suemori; Satoshi Mishima; Hideaki Hara
Brazilian green propolis protects against retinal damage in vitro and in vivo.
Evidence-based complementary and alternative medicine : eCAM 2006;3(1):71-7.
2006: Masamitsu Shimazawa; Goji Tomita; Takazumi Taniguchi; M Sasaoka; Hideaki Hara; Yoshiaki Kitazawa; Makoto Araie
Morphometric evaluation of changes with time in optic disc structure and thickness of retinal nerve fibre layer in chronic ocular hypertensive monkeys.
Experimental eye research 2006;82(3):427-40.
2006: Hideaki Hara; Kentaro Oh-Hashi; Shinji Yoneda; Masamitsu Shimazawa; Masaru Inatani; Hidenobu Tanihara; Kazutoshi Kiuchi
Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy.
Molecular vision 2006;12():977-82.
2006: Masamitsu Shimazawa; Takazumi Taniguchi; M Sasaoka; Hideaki Hara
Nerve fiber layer measurement using scanning laser polarimetry with fixed corneal compensator in normal cynomolgus monkey eyes.
Ophthalmic research 2006;38(1):1-7.
2005: Takahiro Akaishi; Naruhiro Ishida; Atsushi Shimazaki; Hideaki Hara; Yasuaki Kuwayama
Continuous monitoring of circadian variations in intraocular pressure by telemetry system throughout a 12-week treatment with timolol maleate in rabbits.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2005;21(6):436-44.
2005: Masamitsu Shimazawa; Tetsumori Yamashima; Neeraj Agarwal; Hideaki Hara
Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage.
Brain research 2005;1053(1-2):185-94.
2005: Takazumi Taniguchi; Masamitsu Shimazawa; Makoto Araie; G Tomita; M Sasaoka; Y Kitazawa; Hideaki Hara
Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography.
The British journal of ophthalmology 2005;89(8):1058-62.
2005: Nobutaka Morimoto; Masamitsu Shimazawa; Tetsumori Yamashima; Hiroichi Nagai; Hideaki Hara
Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage.
Brain research 2005;1044(1):8-15.
2005: Shinji Yoneda; Hideaki Hara; Akira Hirata; Mikiko Fukushima; Yasuya Inomata; Hidenobu Tanihara
Vitreous fluid levels of beta-amyloid((1-42)) and tau in patients with retinal diseases.
Japanese journal of ophthalmology 2005;49(2):106-8.
2005: Shinji Yoneda; Masamitsu Shimazawa; Masanori Kato; Akira Nonoyama; Yasushi Torii; Hajime Nishino; Nakaba Sugimoto; Shunji Kozaki; Hideaki Hara
Comparison of the therapeutic indexes of different molecular forms of botulinum toxin type A.
European journal of pharmacology 2005;508(1-3):223-9.
2005: Hideaki Hara; Masaki Ichikawa; Hidehiro Oku; Masamitsu Shimazawa; Makoto Araie
Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage.
Cardiovascular drug reviews 2005;23(1):43-56.
2004: Rie Yamamoto; Shinji Yoneda; Hideaki Hara
Neuroprotective effects of beta-secretase inhibitors against rat retinal ganglion cell death.
Neuroscience letters 2004;370(1):61-4.
2004: Yuji Okada; Masaki Ichikawa; Kiyoshi Ishii; Hideaki Hara
Effects of topically instilled bunazosin hydrochloride and other ocular hypotensive drugs on endothelin-1-induced constriction in rabbit retinal arteries.
Japanese journal of ophthalmology 2004;48(5):465-9.
2004: Takahiro Akaishi; Yasutaka Takagi; Takeshi Matsugi; Naruhiro Ishida; Hideaki Hara; Kenji Kashiwagi
Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities.
Journal of glaucoma 2004;13(4):312-8.
2004: Takazumi Taniguchi; Masamitsu Shimazawa; Hideaki Hara
Alterations in neurofilament light in optic nerve in rat kainate and monkey ocular hypertension models.
Brain research 2004;1013(2):241-8.
2004: Atsushi Shimazaki; Masaki Ichikawa; P Vasantha Rao; Tomoko Kirihara; Kouji Konomi; David L Epstein; Hideaki Hara
Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys.
Biological & pharmaceutical bulletin 2004;27(7):1019-24.
2004: Atsushi Shimazaki; Hiroshi Suhara; Masaki Ichikawa; Takeshi Matsugi; Koji Konomi; Yasutaka Takagi; Hideaki Hara; P Vasantha Rao; David L Epstein
New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells.
Biological & pharmaceutical bulletin 2004;27(6):846-50.
2004: Yasutaka Takagi; Tadashi Nakajima; Atsushi Shimazaki; Masaaki Kageyama; Takeshi Matsugi; Yasushi Matsumura; B'Ann T Gabelt; Paul L Kaufman; Hideaki Hara
Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug.
Experimental eye research 2004;78(4):767-76.
2004: Hideaki Hara; Nobuko Toriu; Masamitsu Shimazawa
Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage.
Cardiovascular drug reviews 2004;22(3):199-214.
2003: Tadashi Nakajima; Takeshi Matsugi; Wakana Goto; Masaaki Kageyama; Nobuaki Mori; Yasushi Matsumura; Hideaki Hara
New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents.
Biological & pharmaceutical bulletin 2003;26(12):1691-5.
2003: Takahiro Akaishi; Atsushi Shimazaki; Takeshi Matsugi; Nobuaki Miyawaki; Hideaki Hara; Yasuaki Kuwayama
[Effects of ocular hypotensive agents on the circadian rhythm in intraocular pressure in rabbits as measured by telemetry].
Nippon Ganka Gakkai zasshi 2003;107(9):513-8.
2002: Wakana Goto; Takashi Ota; Nobuo Morikawa; Yasumasa Otori; Hideaki Hara; Kouichi Kawazu; Nobuaki Miyawaki; Yasuo Tano
Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina.
Brain research 2002;958(1):10-9.
2002: Takashi Ota; Hideaki Hara; Nobuaki Miyawaki
Brain-derived neurotrophic factor inhibits changes in soma-size of retinal ganglion cells following optic nerve axotomy in rats.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2002;18(3):241-9.
2001: S Yoneda; Hidenobu Tanihara; Noriaki Kido; Yoshihito Honda; Wakana Goto; Hideaki Hara; Nobuaki Miyawaki
Interleukin-1beta mediates ischemic injury in the rat retina.
Experimental eye research 2001;73(5):661-7.
2001: Noriaki Kido; Masaru Inatani; Megumi Honjo; S Yoneda; Hideaki Hara; Nobuaki Miyawaki; Yoshihito Honda; Hidenobu Tanihara
Dual effects of interleukin-1beta on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes.
Brain research 2001;910(1-2):153-62.
2001: Nobuko Toriu; M Sasaoka; Masamitsu Shimazawa; T Sugiyama; Hideaki Hara
Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2001;17(2):131-49.
2000: Nobuko Toriu; Akinori Akaike; Hiroki Yasuyoshi; Shen Zhang; Satoshi Kashii; Yoshihito Honda; Masamitsu Shimazawa; Hideaki Hara
Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina.
Experimental eye research 2000;70(4):475-84.
1999: Hideaki Hara; Masamitsu Shimazawa; M Sasaoka; C Yamada; Y Iwakura; T Sakai; Y Maeda; T Yamaguchi; T Sukamoto; M Hashimoto
Selective effects of lomerizine, a novel diphenylmethylpiperazine Ca2+ channel blocker, on cerebral blood flow in rats and dogs.
Clinical and experimental pharmacology & physiology 1999;26(11):870-6.