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Kenta Hara

Research Profile

Phenomena

Phosphorylation

Chemicals & Drugs

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Type 1 Diabetes Mellitus

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Amino Acid Sequences

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TOP 3
Hirotomo Sasaki; Hisafumi Yasuda; Hiroaki Moriyama; Akira Nakamura; Mami Shimizu; Takashi Arai; Masao Nagata; Kenta Hara; Koichi Yokono
Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation.
Takashi Arai; Hiroaki Moriyama; Mami Shimizu; Hirotomo Sasaki; Minoru Kishi; Yasuyo Okumachi; Hisafumi Yasuda; Kenta Hara; Koichi Yokono; Masao Nagata
Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice.
Minoru Kishi; Hisafumi Yasuda; Yasuhisa Abe; Hirotomo Sasaki; Mami Shimizu; Takashi Arai; Yasuyo Okumachi; Hiroaki Moriyama; Kenta Hara; Koichi Yokono; Masao Nagata
Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-beta suppress autoimmune diabetes.

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All Publications

2011: Hirotomo Sasaki; Hisafumi Yasuda; Hiroaki Moriyama; Akira Nakamura; Mami Shimizu; Takashi Arai; Masao Nagata; Kenta Hara; Koichi Yokono
Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation.
Biochemical and biophysical research communications 2011;408(2):306-11.
2010: Takashi Arai; Hiroaki Moriyama; Mami Shimizu; Hirotomo Sasaki; Minoru Kishi; Yasuyo Okumachi; Hisafumi Yasuda; Kenta Hara; Koichi Yokono; Masao Nagata
Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice.
Clinical immunology (Orlando, Fla.) 2010;136(1):74-82.
2010: Minoru Kishi; Hisafumi Yasuda; Yasuhisa Abe; Hirotomo Sasaki; Mami Shimizu; Takashi Arai; Yasuyo Okumachi; Hiroaki Moriyama; Kenta Hara; Koichi Yokono; Masao Nagata
Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-beta suppress autoimmune diabetes.
Biochemical and biophysical research communications 2010;394(1):228-32.
2010: Hisafumi Yasuda; Masao Nagata; Kenta Hara; Hiroaki Moriyama; Koichi Yokono
Biguanide, but not thiazolidinedione, improved insulin resistance in Werner syndrome.
Journal of the American Geriatrics Society 2010;58(1):181-2.
2009: Suirin Hamada; Kenta Hara; Takeshi Hamada; Hisafumi Yasuda; Hiroaki Moriyama; Rika Nakayama; Masao Nagata; Koichi Yokono
Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia.
Diabetes 2009;58(6):1321-32.
2008: Hiroaki Moriyama; Reiko Kotani; Atsumi Katsuta; Mami Kameno; Takashi Arai; Yasuyo Okumachi; Minoru Kishi; Katsumi Yamada; Hisafumi Yasuda; Kenta Hara; Koichi Yokono; Masao Nagata
Autoreactive T cell response in CD25-negative fraction of peripheral blood mononuclear cells in established type 1 diabetes.
Annals of the New York Academy of Sciences 2008;1150():278-81.
2008: Katsumi Yamada; Hiroaki Moriyama; Yasuyo Okumachi; Takashi Arai; Mami Kameno; Minoru Kishi; Hisafumi Yasuda; Kenta Hara; Koichi Yokono; Masao Nagata
Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice.
Annals of the New York Academy of Sciences 2008;1150():183-6.
2008: Yasuyo Okumachi; Hiroaki Moriyama; Mami Kameno; Takashi Arai; Minoru Kishi; Midori Kurohara; Katsumi Yamada; Hisafumi Yasuda; Kenta Hara; Koichi Yokono; Masao Nagata
One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide.
Biochemical and biophysical research communications 2008;374(3):581-6.
2008: Mami Kameno; Toshihiro Takata; Hisahumi Yasuda; Kenta Hara; Hiroyuki Okano; Takashi Sakurai; Masao Nagata; Koichi Yokono
[A case of elderly onset loss of consciousness due to bacterial meningitis and subsequent vasculitis].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2008;45(4):434-8.
2008: Muneaki Sakata; Hisafumi Yasuda; Hiroaki Moriyama; Katsumi Yamada; Reiko Kotani; Midori Kurohara; Yasuyo Okumachi; Minoru Kishi; Takashi Arai; Kenta Hara; Hirofumi Hamada; Koichi Yokono; Masao Nagata
Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules.
Diabetes research and clinical practice 2008;80(3):352-9.
2008: Midori Kurohara; Hisafumi Yasuda; Hiroaki Moriyama; Maki Nakayama; Muneaki Sakata; Katsumi Yamada; Reiko Kotani; Kenta Hara; Koichi Yokono; Masao Nagata
Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes.
The Kobe journal of medical sciences 2008;54(1):E1-13.
2007: Masao Nagata; Hiroaki Moriyama; Reiko Kotani; Hisafumi Yasuda; Minoru Kishi; Midori Kurohara; Kenta Hara; Koichi Yokono
Immunological aspects of 'fulminant type 1 diabetes'.
Diabetes research and clinical practice 2007;77 Suppl 1():S99-103.
2007: Hiroaki Moriyama; Masao Nagata; Takashi Arai; Yasuyo Okumachi; Katsumi Yamada; Reiko Kotani; Hisafumi Yasuda; Kenta Hara; Koichi Yokono
Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice.
Diabetes research and clinical practice 2007;77 Suppl 1():S155-60.
2007: Noriko Oshiro; Rinako Takahashi; Ken-ichi Yoshino; Keiko Tanimura; Akio Nakashima; Satoshi Eguchi; Takafumi Miyamoto; Kenta Hara; Kenji Takehana; Joseph Avruch; Ushio Kikkawa; Kazuyoshi Yonezawa
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
The Journal of biological chemistry 2007;282(28):20329-39.
2007: Katsumi Yamada; Hiroaki Moriyama; Hisafumi Yasuda; Kenta Hara; Yoshimasa Maniwa; Hirofumi Hamada; Koichi Yokono; Masao Nagata
Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity.
Human gene therapy 2007;18(5):389-400.
2007: Jing Zhou; Kenta Hara; M Inoue; Suirin Hamada; Hisafumi Yasuda; Hiroaki Moriyama; Hiroko Endo; Kiichi Hirota; Kazuyoshi Yonezawa; Masao Nagata; Koichi Yokono
Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.
The Kobe journal of medical sciences 2007;53(6):283-96.
2006: Goh Ohji; Masao Nagata; Kenta Hara; Toshioki Matsuzawa; Noriyuki Hata; Hisafumi Yasuda; Takashi Sakurai; Hiroyuki Okano; Koichi Yokono
[Group B streptococcal vertebral osteomyelitis following superficial suppurative thrombophlebitis].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2006;43(5):635-8.
2005: C W Danawati; Masao Nagata; Hiroaki Moriyama; Kenta Hara; Hisafumi Yasuda; Maki Nakayama; Reiko Kotani; Katsumi Yamada; M Sakata; Midori Kurohara; P Wiyono; H Asdie; M Sakaue; H Taniguchi; Koichi Yokono
A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia.
Diabetes/metabolism research and reviews 2005;21(5):465-9.
2004: Noriko Oshiro; Ken-ichi Yoshino; Sujuti Hidayat; Chiharu Tokunaga; Kenta Hara; Satoshi Eguchi; Joseph Avruch; Kazuyoshi Yonezawa
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(4):359-66.
2004: Kazuyoshi Yonezawa; Ken-ichi Yoshino; Chiharu Tokunaga; Kenta Hara
Kinase activities associated with mTOR.
Current topics in microbiology and immunology 2004;279():271-82.
2003: Hiroki Nojima; Chiharu Tokunaga; Satoshi Eguchi; Noriko Oshiro; Sujuti Hidayat; Ken-ichi Yoshino; Kenta Hara; Noriaki Tanaka; Joseph Avruch; Kazuyoshi Yonezawa
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.
The Journal of biological chemistry 2003;278(18):15461-4.
2003: Sujuti Hidayat; Ken-ichi Yoshino; Chiharu Tokunaga; Kenta Hara; Masafumi Matsuo; Kazuyoshi Yonezawa
Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.
Biochemical and biophysical research communications 2003;301(2):417-23.
2003: Naoki Kimura; Chiharu Tokunaga; Sushila Dalal; Christine Richardson; Ken-ichi Yoshino; Kenta Hara; Bruce E Kemp; Lee A Witters; Osamu Mimura; Kazuyoshi Yonezawa
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(1):65-79.
2002: Kenta Hara; Yoshiko Maruki; Xiaomeng Long; Ken-ichi Yoshino; Noriko Oshiro; Sujuti Hidayat; Chiharu Tokunaga; Joseph Avruch; Kazuyoshi Yonezawa
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Cell 2002;110(2):177-89.
2001: T Minami; Kenta Hara; Noriko Oshiro; S Ueoku; Ken-ichi Yoshino; Chiharu Tokunaga; Yasuhito Shirai; Naoaki Saito; I Gout; Kazuyoshi Yonezawa
Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(11):1003-15.
2000: T Takahashi; Kenta Hara; H Inoue; Y Kawa; Chiharu Tokunaga; Sujuti Hidayat; Ken-ichi Yoshino; Y Kuroda; Kazuyoshi Yonezawa
Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(9):765-75.
1999: Shuji Isotani; Kenta Hara; Chiharu Tokunaga; H Inoue; Joseph Avruch; Kazuyoshi Yonezawa
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro.
The Journal of biological chemistry 1999;274(48):34493-8.
1999: K Shigemitsu; Y Tsujishita; H Miyake; Sujuti Hidayat; N Tanaka; Kenta Hara; Kazuyoshi Yonezawa
Structural requirement of leucine for activation of p70 S6 kinase.
FEBS letters 1999;447(2-3):303-6.
1999: M Nanahoshi; Y Tsujishita; Chiharu Tokunaga; S Inui; N Sakaguchi; Kenta Hara; Kazuyoshi Yonezawa
Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases.
FEBS letters 1999;446(1):108-12.
1999: K Shigemitsu; Y Tsujishita; Kenta Hara; M Nanahoshi; Joseph Avruch; Kazuyoshi Yonezawa
Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells.
The Journal of biological chemistry 1999;274(2):1058-65.
1998: Teruaki Nishiuma; Kenta Hara; Y Tsujishita; K Kaneko; K Shii; Kazuyoshi Yonezawa
Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates.
Biochemical and biophysical research communications 1998;252(2):440-4.
1998: M Nanahoshi; Teruaki Nishiuma; Y Tsujishita; Kenta Hara; S Inui; N Sakaguchi; Kazuyoshi Yonezawa
Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42.
Biochemical and biophysical research communications 1998;251(2):520-6.
1996: T Kitamura; Y Kitamura; Kazuyoshi Yonezawa; Nick Totty; Ivan T Gout; Kenta Hara; M D Waterfield; M Sakaue; Wataru Ogawa; Masato Kasuga
Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck.
Biochemical and biophysical research communications 1996;219(2):509-14.
1995: Hiroshi Sakaue; Kenta Hara; Tetsuya Noguchi; Takashi Matozaki; Ko Kotani; Wataru Ogawa; Kazuyoshi Yonezawa; M D Waterfield; Masato Kasuga
Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells.
The Journal of biological chemistry 1995;270(19):11304-9.
1995: Ko Kotani; A J Carozzi; Hiroshi Sakaue; Kenta Hara; L J Robinson; SF Clark; Kazuyoshi Yonezawa; David E James; Masato Kasuga
Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 1995;209(1):343-8.
1995: Ko Kotani; Kenta Hara; K Kotani; Kazuyoshi Yonezawa; Masato Kasuga
Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling.
Biochemical and biophysical research communications 1995;208(3):985-90.
1995: Kenta Hara; Kazuyoshi Yonezawa; Hiroshi Sakaue; Ko Kotani; K Kotani; A Kojima; M D Waterfield; Masato Kasuga
Normal activation of p70 S6 kinase by insulin in cells overexpressing dominant negative 85kD subunit of phosphoinositide 3-kinase.
Biochemical and biophysical research communications 1995;208(2):735-41.
1994: Kenta Hara; Kazuyoshi Yonezawa; Hiroshi Sakaue; A Ando; Ko Kotani; T Kitamura; Y Kitamura; H Ueda; Len Stephens; Trevor Jackson
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7415-9.
1994: A Ando; Kazuyoshi Yonezawa; Ivan T Gout; T Nakata; H Ueda; Kenta Hara; Y Kitamura; Y Noda; T Takenawa; N Hirokawa
A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.
The EMBO journal 1994;13(13):3033-8.
1994: Ko Kotani; Kazuyoshi Yonezawa; Kenta Hara; H Ueda; Y Kitamura; Hiroshi Sakaue; A Ando; Alain Chavanieu; Bernard Calas; FLORIN GRIGORESCU
Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.
The EMBO journal 1994;13(10):2313-21.
1994: Kazuyoshi Yonezawa; A Ando; Yasushi Kaburagi; Ritsuko Yamamoto-Honda; T Kitamura; Kenta Hara; M Nakafuku; Yoshinori Okabayashi; Takashi Kadowaki; Y Kaziro
Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.
The Journal of biological chemistry 1994;269(6):4634-40.
1992: Kazuyoshi Yonezawa; H Ueda; Kenta Hara; K Nishida; A Ando; Alain Chavanieu; H Matsuba; K Shii; Koichi Yokono; Y Fukui
Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.
The Journal of biological chemistry 1992;267(36):25958-65.
1992: Kazuyoshi Yonezawa; Koichi Yokono; K Shii; Wataru Ogawa; A Ando; Kenta Hara; S Baba; Yasushi Kaburagi; Ritsuko Yamamoto-Honda; K Momomura
In vitro association of phosphatidylinositol 3-kinase activity with the activated insulin receptor tyrosine kinase.
The Journal of biological chemistry 1992;267(1):440-6.