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Alejandro Aruffo

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Christian P Larsen; Eric T. Elwood; Diane Z Alexander; Shannon C Ritchie; Rose Hendrix; Carol Tucker-Burden; Hong Rae Cho; Alejandro Aruffo; Diane Hollenbaugh; Peter S Linsley; Kevin J Winn; Thomas C Pearson
Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.
Diane Hollenbaugh; Alejandro Aruffo; Bryan Jones; Peter Linsley
Use of monoclonal antibodies for expression cloning.
Alejandro Aruffo
Transient expression of proteins using COS cells.

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All Publications

2011: Christian P Larsen; Eric T. Elwood; Diane Z Alexander; Shannon C Ritchie; Rose Hendrix; Carol Tucker-Burden; Hong Rae Cho; Alejandro Aruffo; Diane Hollenbaugh; Peter S Linsley; Kevin J Winn; Thomas C Pearson
Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):2693-7.
2003: Diane Hollenbaugh; Alejandro Aruffo; Bryan Jones; Peter Linsley
Use of monoclonal antibodies for expression cloning.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2003;Chapter 6():Unit 6.11.
2002: Alejandro Aruffo
Transient expression of proteins using COS cells.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2002;Chapter 16():Unit 16.12.
2002: Thomas C Pearson; Joel Trambley; Kris Odom; Daniel Anderson; Shannon Cowan; Robert A. Bray; Angello Lin; Diane L Hollenbaugh; Alejandro Aruffo; Anthony W Siadak; Elizabeth Strobert; Randolph A Hennigar; Christian P Larsen
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
Transplantation 2002;74(7):933-40.
2002: JS Ahn; A Konno; john gebe; Alejandro Aruffo; Mary Jo Hamilton; Yong Ho Park; William C Davis
Scavenger receptor cysteine-rich domains 9 and 11 of WC1 are receptors for the WC1 counter receptor.
Journal of leukocyte biology 2002;72(2):382-90.
2002: Diane Hollenbaugh; Alejandro Aruffo
Construction of immunoglobulin fusion proteins.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002;Chapter 10():Unit 10.19A.
2001: Alejandro Aruffo; Diane L Hollenbaugh
Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease.
Current opinion in immunology 2001;13(6):683-6.
2001: Helmut R Salih; Gary C Starling; Markus Knauff; MB Llewellyn; PM Davis; William J Pitts; Alejandro Aruffo; Peter Kiener
Retinoic acid and vitamin E modulate expression and release of CD178 in carcinoma cells: consequences for induction of apoptosis in CD95-sensitive cells.
Experimental cell research 2001;270(2):248-58.
2001: A Konno; JS Ahn; Hiroshi Kitamura; Mary Jo Hamilton; john gebe; Alejandro Aruffo; William C Davis
Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human.
Journal of leukocyte biology 2001;69(6):944-50.
2001: D Hollenbaugh; Alejandro Aruffo; B Jones; P Linsley
Use of monoclonal antibodies for expression cloning.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.18.
2001: Alejandro Aruffo
Transient expression of proteins using COS cells.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Chapter 4():Unit 4.7.
2000: Helmut R Salih; S G Kosowski; V F Haluska; Gary C Starling; D T Loo; F Lee; Alejandro Aruffo; P A Trail; Peter Kiener
Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2903-10.
2000: MA Bowen; Alejandro Aruffo; Jurgen Bajorath
Cell surface receptors and their ligands: in vitro analysis of CD6-CD166 interactions.
Proteins 2000;40(3):420-8.
2000: N Sakata; Eckard H Hamelmann; Anthony W Siadak; N Terada; Pär Gerwins; Alejandro Aruffo; Gary L Johnson; Erwin W Gelfand
Differential regulation of CD40-mediated human B cell responses by antibodies directed against different CD40 epitopes.
Cellular immunology 2000;201(2):109-23.
2000: Richard Pospisil; G J Silverman; G E Marti; Alejandro Aruffo; MA Bowen; Rose G Mage
CD5 is A potential selecting ligand for B-cell surface immunoglobulin: a possible role in maintenance and selective expansion of normal and malignant B cells.
Leukemia & lymphoma 2000;36(3-4):353-65.
2000: john gebe; MB Llewellyn; H Hoggatt; Alejandro Aruffo
Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha.
Immunology 2000;99(1):78-86.
1999: HU Grimme; Christian Termeer; KL Bennett; Johannes M Weiss; Erwin Schöpf; Alejandro Aruffo; Jan C Simon
Colocalization of basic fibroblast growth factor and CD44 isoforms containing the variably spliced exon v3 (CD44v3) in normal skin and in epidermal skin cancers.
The British journal of dermatology 1999;141(5):824-32.
1999: L L Smith; BW Greenfield; Alejandro Aruffo; Cecilia M Giachelli
CD44 is not an adhesive receptor for osteopontin.
Journal of cellular biochemistry 1999;73(1):20-30.
1999: Juan J Perez-Villar; Gena S Whitney; MA Bowen; D H Hewgill; Alejandro Aruffo; Steven B Kanner
CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1.
Molecular and cellular biology 1999;19(4):2903-12.
1999: A von Leoprechting; P van der Bruggen; H L Pahl; Alejandro Aruffo; Jan C Simon
Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis.
Cancer research 1999;59(6):1287-94.
1999: MA Bowen; Alejandro Aruffo
Adhesion molecules, their receptors, and their regulation: analysis of CD6-activated leukocyte cell adhesion molecule (ALCAM/CD166) interactions.
Transplantation proceedings 1999;31(1-2):795-6.
1999: E A Wolff; BW Greenfield; D D Taub; W J Murphy; KL Bennett; Alejandro Aruffo
Generation of artificial proteoglycans containing glycosaminoglycan-modified CD44. Demonstration of the interaction between rantes and chondroitin sulfate.
The Journal of biological chemistry 1999;274(4):2518-24.
1999: BW Greenfield; W C Wang; H Marquardt; Michael Piepkorn; E A Wolff; Alejandro Aruffo; KL Bennett
Characterization of the heparan sulfate and chondroitin sulfate assembly sites in CD44.
The Journal of biological chemistry 1999;274(4):2511-7.
1998: M Niimi; Thomas C Pearson; Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Alejandro Aruffo; Peter Linsley; E Thomas; K Campbell; W C Fanslow; R S Geha; Peter J Morris; Kathryn J Wood
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5331-7.
1998: K Seyama; Shigeaki Nonoyama; I Gangsaas; Diane L Hollenbaugh; H F Pabst; Alejandro Aruffo; Hans D Ochs
Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.
Blood 1998;92(7):2421-34.
1998: DT Loo; Steven B Kanner; Alejandro Aruffo
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction.
The Journal of biological chemistry 1998;273(36):23304-12.
1998: C B Wilson; L J Embree; D Schowalter; R Albert; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; M A Kay
Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration.
Journal of virology 1998;72(9):7542-50.
1998: Gabriel Bikah; F M Lynd; Alejandro Aruffo; J A Ledbetter; Subbarao Bondada
A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5.
International immunology 1998;10(8):1185-96.
1998: Eric T. Elwood; Christian P Larsen; Hong Rae Cho; Matthias Corbascio; S C Ritchie; DZ Alexander; Carol Tucker-Burden; Peter Linsley; Alejandro Aruffo; Diane L Hollenbaugh; K J Winn; Thomas C Pearson
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.
Transplantation 1998;65(11):1422-8.
1998: Gary C Starling; Peter Kiener; Alejandro Aruffo; Jurgen Bajorath
Analysis of the ligand binding site in Fas (CD95) by site-directed mutagenesis and comparison with TNFR and CD40.
Biochemistry 1998;37(11):3723-6.
1998: I Melero; N Bach; Karl Erik Hellström; Alejandro Aruffo; Robert S Mittler; L Chen
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway.
European journal of immunology 1998;28(3):1116-21.
1998: Shigeaki Nonoyama; A Etzioni; H Toru; D P Ruggerie; D Lewis; S Pollack; Alejandro Aruffo; Jun-Ichi Yata; Hans D Ochs
Diminished expression of CD40 ligand may contribute to the defective humoral immunity in patients with MHC class II deficiency.
European journal of immunology 1998;28(2):589-98.
1998: J Bajorath; BW Greenfield; S B Munro; A J Day; Alejandro Aruffo
Identification of CD44 residues important for hyaluronan binding and delineation of the binding site.
The Journal of biological chemistry 1998;273(1):338-43.
1997: Jörg Kobarg; Gena S Whitney; D Palmer; Alejandro Aruffo; MA Bowen
Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains.
European journal of immunology 1997;27(11):2971-80.
1997: KL Bennett; J Bradshaw; T Youngman; J Rodgers; BW Greenfield; Alejandro Aruffo; Peter Linsley
Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain.
The Journal of biological chemistry 1997;272(43):26940-6.
1997: Michael Piepkorn; P Hovingh; KL Bennett; Alejandro Aruffo; A Linker
Chondroitin sulphate composition and structure in alternatively spliced CD44 fusion proteins.
The Biochemical journal 1997;327 ( Pt 2)():499-506.
1997: Alejandro Aruffo; MA Bowen; Dhavalkumar D Patel; B F Haynes; Gary C Starling; john gebe; Jurgen Bajorath
CD6-ligand interactions: a paradigm for SRCR domain function?
Immunology today 1997;18(10):498-504.
1997: Qili Zhu; C Watanabe; T Liu; Diane L Hollenbaugh; R. Michael Blaese; Steven B Kanner; Alejandro Aruffo; Hans D Ochs
Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype.
Blood 1997;90(7):2680-9.
1997: Anne Marinier; Alain Martel; Jacques Banville; Carol Bachand; Roger Remillard; Philippe Lapointe; B Turmel; M Menard; W E Harte; John J Wright; Gordon Todderud; KM Tramposch; J Bajorath; Diane L Hollenbaugh; Alejandro Aruffo
Sulfated galactocerebrosides as potential antiinflammatory agents.
Journal of medicinal chemistry 1997;40(20):3234-47.
1997: Gordon Todderud; X Nair; D Lee; JG Alford; LB Davern; P Stanley; Carol Bachand; Philippe Lapointe; Anne Marinier; Alain Martel; M Menard; John J Wright; J Bajorath; Diane L Hollenbaugh; Alejandro Aruffo; KM Tramposch
BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1298-304.
1997: JE Skonier; D L Bodian; John Emswiler; MA Bowen; Alejandro Aruffo; Jurgen Bajorath
Mutational analysis of the CD6 ligand binding domain.
Protein engineering 1997;10(8):943-7.
1997: CH Clegg; J T Rulffes; Harald S Haugen; I H Hoggatt; Alejandro Aruffo; S K Durham; Andrew G Farr; Diane L Hollenbaugh
Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice.
International immunology 1997;9(8):1111-22.
1997: JE Skonier; MA Bowen; Alejandro Aruffo; Jurgen Bajorath
CD6 recognizes the neural adhesion molecule BEN.
Protein science : a publication of the Protein Society 1997;6(8):1768-70.
1997: WW Shuford; K Klussman; D D Tritchler; DT Loo; J Chalupny; Anthony W Siadak; T J Brown; John Emswiler; H Raecho; Christian P Larsen; Thomas C Pearson; Jeffrey A Ledbetter; Alejandro Aruffo; Robert S Mittler
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
The Journal of experimental medicine 1997;186(1):47-55.
1997: MA Bowen; Jurgen Bajorath; Maurizia D'Egidio; Gena S Whitney; D Palmer; Jörg Kobarg; Gary C Starling; Anthony W Siadak; Alejandro Aruffo
Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding.
European journal of immunology 1997;27(6):1469-78.
1997: I Melero; WW Shuford; S A Newby; Alejandro Aruffo; Jeffrey A Ledbetter; Karl Erik Hellström; Robert S Mittler; L Chen
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.
Nature medicine 1997;3(6):682-5.
1997: Mark A Kay; Leonard Meuse; A M Gown; Peter Linsley; Diane L Hollenbaugh; Alejandro Aruffo; Hans D Ochs; Christopher B Wilson
Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4686-91.
1997: Gary C Starling; Jurgen Bajorath; John Emswiler; Jeffrey A Ledbetter; Alejandro Aruffo; Peter Kiener
Identification of amino acid residues important for ligand binding to Fas.
The Journal of experimental medicine 1997;185(8):1487-92.
1997: J Golik; J K Dickey; Gordon Todderud; D Lee; JG Alford; Stella Huang; Steven E Klohr; D Eustice; Alejandro Aruffo; M L Agler
Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.
Journal of natural products 1997;60(4):387-9.
1997: DT Loo; N J Chalupny; J Bajorath; WW Shuford; Robert S Mittler; Alejandro Aruffo
Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB.
The Journal of biological chemistry 1997;272(10):6448-56.
1997: john gebe; Peter Kiener; HZ Ring; X Li; U Francke; Alejandro Aruffo
Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins.
The Journal of biological chemistry 1997;272(10):6151-8.
1997: D L Bodian; JE Skonier; MA Bowen; M Neubauer; Anthony W Siadak; Alejandro Aruffo; Jurgen Bajorath
Identification of residues in CD6 which are critical for ligand binding.
Biochemistry 1997;36(9):2637-41.
1997: MA Bowen; Gena S Whitney; M Neubauer; Gary C Starling; D Palmer; J Zhang; Norma J Nowak; TB Shows; Alejandro Aruffo
Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1149-56.
1997: Jeffrey A Ledbetter; Joseph A Francisco; Clay B Siegall; L K Gilliland; Diane L Hollenbaugh; Alejandro Aruffo; Anthony W Siadak; N Mischel-Petty; LS Grosmaire; M L Gordon; T J Brown; P Moran-Davis; Robert S Mittler; Peter Kiener; Steven G Nadler
Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.
Critical reviews in immunology 1997;17(5-6):427-35.
1997: Ronald E Stenkamp; Alejandro Aruffo; J Bajorath
Protein superfamily members as targets for computer modeling: the carbohydrate recognition domain of a macrophage lectin.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 1997;():432-40.
1997: Jurgen Bajorath; Alejandro Aruffo
Prediction of the three-dimensional structure of the human Fas receptor by comparative molecular modeling.
Journal of computer-aided molecular design 1997;11(1):3-8.
1997: Jurgen Bajorath; Alejandro Aruffo
Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40.
Proteins 1997;27(1):59-70.
1997: Gary C Starling; MB Llewellyn; Gena S Whitney; Alejandro Aruffo
The Ly-1.1 and Ly-1.2 epitopes of murine CD5 map to the membrane distal scavenger receptor cysteine-rich domain.
Tissue antigens 1997;49(1):1-6.
1996: J E Skonier; MA Bowen; John Emswiler; Alejandro Aruffo; J Bajorath
Mutational analysis of the CD6 binding site in activated leukocyte cell adhesion molecule.
Biochemistry 1996;35(47):14743-8.
1996: Ralf W Denfeld; Diane L Hollenbaugh; A Fehrenbach; Johannes M Weiss; A von Leoprechting; B Mai; U Voith; Erwin Schöpf; Alejandro Aruffo; Jan C Simon
CD40 is functionally expressed on human keratinocytes.
European journal of immunology 1996;26(10):2329-34.
1996: J E Skonier; MA Bowen; John Emswiler; Alejandro Aruffo; J Bajorath
Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.
Biochemistry 1996;35(38):12287-91.
1996: L Biancone; Michael A Bowen; A Lim; Alejandro Aruffo; G Andres; Ivan Stamenkovic
Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes.
The Journal of experimental medicine 1996;184(3):811-9.
1996: Mark D Cunningham; C Seachord; K Ratcliffe; Brian W Bainbridge; Alejandro Aruffo; Richard P Darveau
Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14.
Infection and immunity 1996;64(9):3601-8.
1996: W Conrad Liles; Peter Kiener; Jeffrey A Ledbetter; Alejandro Aruffo; Seymour J Klebanoff
Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.
The Journal of experimental medicine 1996;184(2):429-40.
1996: MA Bowen; J Bajorath; Anthony W Siadak; B Modrell; A R Malacko; H Marquardt; Steven G Nadler; Alejandro Aruffo
The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry.
The Journal of biological chemistry 1996;271(29):17390-6.
1996: Stuart J Kahn; M Wleklinski; R A Ezekowitz; D Coder; Alejandro Aruffo; A Farr
The major surface glycoprotein of Trypanosoma cruzi amastigotes are ligands of the human serum mannose-binding protein.
Infection and immunity 1996;64(7):2649-56.
1996: Christian P Larsen; Eric T. Elwood; DZ Alexander; S C Ritchie; R Hendrix; Carol Tucker-Burden; H R Cho; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; K J Winn; Thomas C Pearson
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.
Nature 1996;381(6581):434-8.
1996: Gary C Starling; Gena S Whitney; Anthony W Siadak; M B Llewellyn; MA Bowen; Andrew G Farr; Alejandro Aruffo
Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction.
European journal of immunology 1996;26(4):738-46.
1996: J Bajorath; K Seyama; Shigeaki Nonoyama; Hans D Ochs; Alejandro Aruffo
Classification of mutations in the human CD40 ligand, gp39, that are associated with X-linked hyper IgM syndrome.
Protein science : a publication of the Protein Society 1996;5(3):531-4.
1996: A Bartolazzi; A Nocks; Alejandro Aruffo; F Spring; Ivan Stamenkovic
Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan.
The Journal of cell biology 1996;132(6):1199-208.
1996: J Bajorath; Alejandro Aruffo
Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.
Protein science : a publication of the Protein Society 1996;5(2):240-7.
1996: A J Nelson; Robert J Dunn; Robert Peach; Alejandro Aruffo; Andrew G Farr
The murine homolog of human Ep-CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells.
European journal of immunology 1996;26(2):401-8.
1996: Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Eric T. Elwood; S C Ritchie; Alejandro Aruffo; R Hendrix; Thomas C Pearson
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.
Transplantation 1996;61(1):4-9.
1995: Diane L Hollenbaugh; J Douthwright; V McDonald; Alejandro Aruffo
Cleavable CD40Ig fusion proteins and the binding to sgp39.
Journal of immunological methods 1995;188(1):1-7.
1995: L A Schubert; G King; Randy Q Cron; David B Lewis; Alejandro Aruffo; Diane L Hollenbaugh
The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation.
The Journal of biological chemistry 1995;270(50):29624-7.
1995: KL Bennett; B Modrell; BW Greenfield; A Bartolazzi; Ivan Stamenkovic; Robert Peach; D G Jackson; F Spring; Alejandro Aruffo
Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons.
The Journal of cell biology 1995;131(6 Pt 1):1623-33.
1995: J Bajorath; Alejandro Aruffo
A template for generation and comparison of three-dimensional selectin models.
Biochemical and biophysical research communications 1995;216(3):1018-23.
1995: Peter Kiener; P Moran-Davis; B M Rankin; Alan F Wahl; Alejandro Aruffo; Diane L Hollenbaugh
Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4917-25.
1995: S Kahn; M Wleklinski; Alejandro Aruffo; A Farr; D Coder; M Kahn
Trypanosoma cruzi amastigote adhesion to macrophages is facilitated by the mannose receptor.
The Journal of experimental medicine 1995;182(5):1243-58.
1995: Gordon Todderud; JG Alford; Alejandro Aruffo; KM Tramposch
Phorbol ester-induced upregulation of polymorphonuclear leukocyte P-selectin ligand expression.
Cellular immunology 1995;166(1):16-24.
1995: C P Edwards; Andrew G Farr; J S Marken; A Nelson; J Bajorath; Karl Erik Hellström; Ingegerd Hellström; Alejandro Aruffo
Cloning of the murine counterpart of the tumor-associated antigen H-L6: epitope mapping of the human and murine L6 antigens.
Biochemistry 1995;34(39):12653-60.
1995: N J Chalupny; Alejandro Aruffo; J M Esselstyn; P Y Chan; J Bajorath; J Blake; L K Gilliland; Jeffrey A Ledbetter; Mark Tepper
Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains.
European journal of immunology 1995;25(10):2978-84.
1995: Che-Leung Law; Alejandro Aruffo; K A Chandran; Raymond T Doty; Edward A Clark
Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3368-76.
1995: Robert Peach; J Bajorath; J Naemura; G Leytze; J Greene; Alejandro Aruffo; Peter Linsley
Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
The Journal of biological chemistry 1995;270(36):21181-7.
1995: J Bajorath; J S Marken; N J Chalupny; T L Spoon; Anthony W Siadak; M Gordon; R J Noelle; Diane L Hollenbaugh; Alejandro Aruffo
Analysis of gp39/CD40 interactions using molecular models and site-directed mutagenesis.
Biochemistry 1995;34(31):9884-92.
1995: Gena S Whitney; Gary C Starling; MA Bowen; B Modrell; Anthony W Siadak; Alejandro Aruffo
The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.
The Journal of biological chemistry 1995;270(31):18187-90.
1995: J Bajorath; MA Bowen; Alejandro Aruffo
Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.
Protein science : a publication of the Protein Society 1995;4(8):1644-7.
1995: Diane L Hollenbaugh; N Mischel-Petty; C P Edwards; Jan C Simon; Ralf W Denfeld; Peter Kiener; Alejandro Aruffo
Expression of functional CD40 by vascular endothelial cells.
The Journal of experimental medicine 1995;182(1):33-40.
1995: J M Culouscou; G W Carlton; Alejandro Aruffo
HER4 receptor activation and phosphorylation of Shc proteins by recombinant heregulin-Fc fusion proteins.
The Journal of biological chemistry 1995;270(21):12857-63.
1995: Diane L Hollenbaugh; Alejandro Aruffo; Peter D Senter
Effects of chemical modification on the binding activities of P-selectin mutants.
Biochemistry 1995;34(16):5678-84.
1995: A Bartolazzi; D Jackson; K Bennett; Alejandro Aruffo; R Dickinson; J Shields; N Whittle; Ivan Stamenkovic
Regulation of growth and dissemination of a human lymphoma by CD44 splice variants.
Journal of cell science 1995;108 ( Pt 4)():1723-33.
1995: Dhavalkumar D Patel; S F Wee; LP Whichard; MA Bowen; J M Pesando; Alejandro Aruffo; Barton F Haynes
Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells.
The Journal of experimental medicine 1995;181(4):1563-8.
1995: Richard P Darveau; Mark D Cunningham; T Bailey; C Seachord; K Ratcliffe; Brian W Bainbridge; M Dietsch; Roy C Page; Alejandro Aruffo
Ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and promote neutrophil adhesion.
Infection and immunity 1995;63(4):1311-7.
1995: J Bajorath; N J Chalupny; J S Marken; Anthony W Siadak; J Skonier; M Gordon; Diane L Hollenbaugh; R J Noelle; H D Ochs; Alejandro Aruffo
Identification of residues on CD40 and its ligand which are critical for the receptor-ligand interaction.
Biochemistry 1995;34(6):1833-44.
1995: KL Bennett; D G Jackson; Jan C Simon; E Tanczos; Robert Peach; B Modrell; Ivan Stamenkovic; Greg Plowman; Alejandro Aruffo
CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.
The Journal of cell biology 1995;128(4):687-98.
1995: Richard P Darveau; Mark D Cunningham; C L Seachord; Roy C Page; Alejandro Aruffo
The ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and neutrophil adhesion.
Progress in clinical and biological research 1995;392():69-78.
1995: Gena S Whitney; M Bowen; M Neubauer; Alejandro Aruffo
Cloning and characterization of murine CD6.
Molecular immunology 1995;32(1):89-92.
1995: Shigeaki Nonoyama; L A Penix; C P Edwards; David B Lewis; S Ito; Alejandro Aruffo; Christopher B Wilson; Hans D Ochs
Diminished expression of CD40 ligand by activated neonatal T cells.
The Journal of clinical investigation 1995;95(1):66-75.
1995: J Bajorath; Ronald E Stenkamp; Alejandro Aruffo
Comparison of a protein model with its X-ray structure: the ligand binding domain of E-selectin.
Bioconjugate chemistry 1995;6(1):3-6.
1994: J Bajorath; Alejandro Aruffo
Molecular model of the extracellular lectin-like domain in CD69.
The Journal of biological chemistry 1994;269(51):32457-63.
1994: Steven B Kanner; Alejandro Aruffo; P Y Chan
Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10484-7.
1994: S Wee; W C Wang; Andrew G Farr; A J Nelson; Dhavalkumar D Patel; Barton F Haynes; Peter Linsley; Alejandro Aruffo
Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues.
Cellular immunology 1994;158(2):353-64.
1994: Jeffrey A Ledbetter; LS Grosmaire; Diane L Hollenbaugh; Alejandro Aruffo; Steven G Nadler
Agonistic and antagonistic properties of CD40 mAb G28-5 are dependent on binding valency.
Circulatory shock 1994;44(2):67-72.
1994: Hans D Ochs; Diane L Hollenbaugh; Alejandro Aruffo
The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency.
Seminars in immunology 1994;6(5):337-41.
1994: M T Dietsch; P Y Chan; Steven B Kanner; L K Gilliland; Jeffrey A Ledbetter; Peter Linsley; Alejandro Aruffo
Coengagement of CD2 with LFA-1 or VLA-4 by bispecific ligand fusion proteins primes T cells to respond more effectively to T cell receptor-dependent signals.
Journal of leukocyte biology 1994;56(4):444-52.
1994: P Y Chan; Steven B Kanner; Gena S Whitney; Alejandro Aruffo
A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.
The Journal of biological chemistry 1994;269(32):20567-74.
1994: Diane L Hollenbaugh; L H Wu; H D Ochs; Shigeaki Nonoyama; LS Grosmaire; Jeffrey A Ledbetter; R J Noelle; H Hill; Alejandro Aruffo
The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1.
The Journal of clinical investigation 1994;94(2):616-22.
1994: A Bartolazzi; Robert Peach; Alejandro Aruffo; Ivan Stamenkovic
Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.
The Journal of experimental medicine 1994;180(1):53-66.
1994: J Liu; B Modrell; Alejandro Aruffo; S Scharnowske; M Shoyab
Interactions between oncostatin M and the IL-6 signal transducer, gp130.
Cytokine 1994;6(3):272-8.
1994: J Bajorath; Alejandro Aruffo
Three-dimensional protein models: insights into structure, function, and molecular interactions.
Bioconjugate chemistry 1994;5(3):173-81.
1994: Diane L Hollenbaugh; H D Ochs; R J Noelle; Jeffrey A Ledbetter; Alejandro Aruffo
The role of CD40 and its ligand in the regulation of the immune response.
Immunological reviews 1994;138():23-37.
1994: Nitin Damle; K Klussman; G Leytze; S Myrdal; Alejandro Aruffo; Jeffrey A Ledbetter; Peter Linsley
Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2686-97.
1994: J S Marken; J Bajorath; C P Edwards; Andrew G Farr; G L Schieven; Ingegerd Hellström; Karl Erik Hellström; Alejandro Aruffo
Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody.
The Journal of biological chemistry 1994;269(10):7397-401.
1994: Hans D Ochs; Diane L Hollenbaugh; Alejandro Aruffo
The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency.
Research in immunology 1994;145(3):210-5; discussion 244-9.
1994: Y J Guo; J H Wong; S C Lin; Alejandro Aruffo; Ivan Stamenkovic; Man-Sun Sy
Disruption of T lymphocyte reappearance in anti-Thy-1-treated animals in vivo with soluble CD44 and L-selectin molecules.
Cellular immunology 1994;154(1):202-18.
1994: J Bajorath; Diane L Hollenbaugh; G King; W Harte; D C Eustice; Richard P Darveau; Alejandro Aruffo
CD62/P-selectin binding sites for myeloid cells and sulfatides are overlapping.
Biochemistry 1994;33(6):1332-9.
1994: G A Maresh; J S Marken; M Neubauer; Alejandro Aruffo; Ingegerd Hellström; Karl Erik Hellström; H Marquardt
Cloning and expression of the gene for the melanoma-associated ME20 antigen.
DNA and cell biology 1994;13(2):87-95.
1994: M Farrington; LS Grosmaire; Shigeaki Nonoyama; S H Fischer; Diane L Hollenbaugh; Jeffrey A Ledbetter; R J Noelle; Alejandro Aruffo; Hans D Ochs
CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):1099-103.
1994: Alejandro Aruffo; Diane L Hollenbaugh; L H Wu; H D Ochs
The molecular basis of X-linked agammaglobulinemia, hyper-IgM syndrome, and severe combined immunodeficiency in humans.
Current opinion in hematology 1994;1(1):12-8.
1994: Ivan Stamenkovic; Alejandro Aruffo
Hyaluronic acid receptors.
Methods in enzymology 1994;245():195-216.
1993: Hans D Ochs; Alejandro Aruffo
Advances in X-linked immunodeficiency diseases.
Current opinion in pediatrics 1993;5(6):684-91.
1993: Gena S Whitney; P Y Chan; J Blake; W L Cosand; M G Neubauer; Alejandro Aruffo; Steven B Kanner
Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
DNA and cell biology 1993;12(9):823-30.
1993: J P Deans; G L Schieven; Geraldine L Shu; M A Valentine; L A Gilliland; Alejandro Aruffo; Edward A Clark; Jeffrey A Ledbetter
Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4494-504.
1993: J Bajorath; Ronald E Stenkamp; Alejandro Aruffo
Knowledge-based model building of proteins: concepts and examples.
Protein science : a publication of the Protein Society 1993;2(11):1798-810.
1993: Hans D Ochs; Shigeaki Nonoyama; M L Farrington; S H Fischer; Alejandro Aruffo
The role of adhesion molecules in the regulation of antibody responses.
Seminars in hematology 1993;30(4 Suppl 4):72-9; discussion 80-1.
1993: C P Edwards; Alejandro Aruffo
Current applications of COS cell based transient expression systems.
Current opinion in biotechnology 1993;4(5):558-63.
1993: Nitin Damle; K Klussman; G Leytze; Alejandro Aruffo; Peter Linsley; Jeffrey A Ledbetter
Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2368-79.
1993: Shigeaki Nonoyama; Diane L Hollenbaugh; Alejandro Aruffo; Jeffrey A Ledbetter; Hans D Ochs
B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells.
The Journal of experimental medicine 1993;178(3):1097-102.
1993: Robert Peach; Diane L Hollenbaugh; Ivan Stamenkovic; Alejandro Aruffo
Identification of hyaluronic acid binding sites in the extracellular domain of CD44.
The Journal of cell biology 1993;122(1):257-64.
1993: N J Chalupny; Steven B Kanner; G L Schieven; S F Wee; L K Gilliland; Alejandro Aruffo; Jeffrey A Ledbetter
Tyrosine phosphorylation of CD19 in pre-B and mature B cells.
The EMBO journal 1993;12(7):2691-6.
1993: M T Dietsch; V F Smith; W L Cosand; Nitin Damle; Jeffrey A Ledbetter; Peter Linsley; Alejandro Aruffo
Bispecific receptor globulins, novel tools for the study of cellular interactions. Preparation and characterization of an E-selectin/P-selectin bispecific receptor globulin.
Journal of immunological methods 1993;162(1):123-32.
1993: Jeffrey A Ledbetter; J P Deans; Alejandro Aruffo; LS Grosmaire; Steven B Kanner; J B Bolen; G L Schieven
CD4, CD8 and the role of CD45 in T-cell activation.
Current opinion in immunology 1993;5(3):334-40.
1993: Nitin Damle; K Klussman; G Leytze; H D Ochs; Alejandro Aruffo; Peter Linsley; Jeffrey A Ledbetter
Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7.
Cellular immunology 1993;148(1):144-56.
1993: Diane L Hollenbaugh; J Bajorath; Ronald E Stenkamp; Alejandro Aruffo
Interaction of P-selectin (CD62) and its cellular ligand: analysis of critical residues.
Biochemistry 1993;32(12):2960-6.
1993: Alejandro Aruffo; M Farrington; Diane L Hollenbaugh; X Li; A Milatovich; Shigeaki Nonoyama; J Bajorath; LS Grosmaire; Ronald E Stenkamp; M Neubauer
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
Cell 1993;72(2):291-300.
1993: S Wee; G L Schieven; J M Kirihara; T T Tsu; Jeffrey A Ledbetter; Alejandro Aruffo
Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors.
The Journal of experimental medicine 1993;177(1):219-23.
1992: Diane L Hollenbaugh; LS Grosmaire; C D Kullas; N J Chalupny; S Braesch-Andersen; R J Noelle; Ivan Stamenkovic; Jeffrey A Ledbetter; Alejandro Aruffo
The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.
The EMBO journal 1992;11(12):4313-21.
1992: Alejandro Aruffo; Steven B Kanner; D Sgroi; Jeffrey A Ledbetter; Ivan Stamenkovic
CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10242-6.
1992: Andrew G Farr; M L Berry; A Kim; A J Nelson; M P Welch; Alejandro Aruffo
Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues.
The Journal of experimental medicine 1992;176(5):1477-82.
1992: N J Chalupny; Robert Peach; Diane L Hollenbaugh; Jeffrey A Ledbetter; Andrew G Farr; Alejandro Aruffo
T-cell activation molecule 4-1BB binds to extracellular matrix proteins.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10360-4.
1992: Nitin Damle; K Klussman; Peter Linsley; Alejandro Aruffo; Jeffrey A Ledbetter
Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2541-8.
1992: J Liu; B Modrell; Alejandro Aruffo; J S Marken; T Taga; K Yasukawa; M Murakami; T Kishimoto; M Shoyab
Interleukin-6 signal transducer gp130 mediates oncostatin M signaling.
The Journal of biological chemistry 1992;267(24):16763-6.
1992: H P Fell; M A Gayle; D Yelton; L Lipsich; G L Schieven; J S Marken; Alejandro Aruffo; Karl Erik Hellström; Ingegerd Hellström; J Bajorath
Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site.
The Journal of biological chemistry 1992;267(22):15552-8.
1992: L K Gilliland; G L Schieven; N A Norris; Steven B Kanner; Alejandro Aruffo; Jeffrey A Ledbetter
Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLC gamma 1 SH2 domains.
The Journal of biological chemistry 1992;267(19):13610-6.
1992: Gordon Todderud; JG Alford; K A Millsap; Alejandro Aruffo; KM Tramposch
PMN binding to P-selectin is inhibited by sulfatide.
Journal of leukocyte biology 1992;52(1):85-8.
1992: Nitin Damle; K Klussman; M T Dietsch; N Mohagheghpour; Alejandro Aruffo
GMP-140 (P-selectin/CD62) binds to chronically stimulated but not resting CD4+ T lymphocytes and regulates their production of proinflammatory cytokines.
European journal of immunology 1992;22(7):1789-93.
1992: J S Marken; G L Schieven; Ingegerd Hellström; Karl Erik Hellström; Alejandro Aruffo
Cloning and expression of the tumor-associated antigen L6.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3503-7.
1992: Diane L Hollenbaugh; N J Chalupny; Alejandro Aruffo
Recombinant globulins: novel research tools and possible pharmaceuticals.
Current opinion in immunology 1992;4(2):216-9.
1992: Steven B Kanner; Nitin Damle; J Blake; Alejandro Aruffo; Jeffrey A Ledbetter
CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2023-9.
1992: Nitin Damle; K Klussman; Peter Linsley; Alejandro Aruffo
Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):1985-92.
1992: Ivan Stamenkovic; D Sgroi; Alejandro Aruffo
CD22 binds to alpha-2,6-sialyltransferase-dependent epitopes on COS cells.
Cell 1992;68(6):1003-4.
1992: Alejandro Aruffo; M T Dietsch; H Wan; Karl Erik Hellström; Ingegerd Hellström
Granule membrane protein 140 (GMP140) binds to carcinomas and carcinoma-derived cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2292-6.
1992: Nitin Damle; K Klussman; Alejandro Aruffo
Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):665-71.
1991: H Y Lin; T L Harris; M S Flannery; Alejandro Aruffo; E H Kaji; A Gorn; L F Kolakowski; Harvey Lodish; Steven R Goldring
Expression cloning of an adenylate cyclase-coupled calcitonin receptor.
Science (New York, N.Y.) 1991;254(5034):1022-4.
1991: Alejandro Aruffo; Waldemar Kolanus; Gerd Walz; P Fredman; Brian Seed
CD62/P-selectin recognition of myeloid and tumor cell sulfatides.
Cell 1991;67(1):35-44.
1991: Alejandro Aruffo
Expression cloning systems.
Current opinion in biotechnology 1991;2(5):735-41.
1991: Ivan Stamenkovic; D Sgroi; Alejandro Aruffo; Man-Sun Sy; T Anderson
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells.
Cell 1991;66(6):1133-44.
1991: Ivan Stamenkovic; Alejandro Aruffo; M Amiot; Brian Seed
The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.
The EMBO journal 1991;10(2):343-8.
1991: H Y Lin; T L Harris; M S Flannery; Alejandro Aruffo; E H Kaji; A Gorn; L F Kolakowski; M Yamin; Harvey Lodish; Steven R Goldring
Expression cloning and characterization of a porcine renal calcitonin receptor.
Transactions of the Association of American Physicians 1991;104():265-72.
1990: Gerd Walz; Alejandro Aruffo; Waldemar Kolanus; M Bevilacqua; Brian Seed
Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells.
Science (New York, N.Y.) 1990;250(4984):1132-5.
1990: Alejandro Aruffo; Ivan Stamenkovic; M Melnick; C B Underhill; Brian Seed
CD44 is the principal cell surface receptor for hyaluronate.
Cell 1990;61(7):1303-13.