Alejandro Aruffo

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Chemicals & Drugs

Anatomy

Physiology

Lymphocyte Activation

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Hollenbaugh Diane; Aruffo Alejandro; Jones Bryan; Linsley Peter
Use of monoclonal antibodies for expression cloning.
Aruffo Alejandro
Transient expression of proteins using COS cells.
Pearson Thomas C; Trambley Joel; Odom Kris; Anderson Daniel C; Cowan Shannon; Bray Robert; Lin Angello; Hollenbaugh Diane; Aruffo Alejandro; Siadak Anthony W; Strobert Elizabeth; Hennigar Randall; Larsen Christian P
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.

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All Publications

2003: Hollenbaugh Diane; Aruffo Alejandro; Jones Bryan; Linsley Peter
Use of monoclonal antibodies for expression cloning.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2003;Chapter 6():Unit 6.11.
2002: Aruffo Alejandro
Transient expression of proteins using COS cells.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2002;Chapter 16():Unit 16.12.
2002: Pearson Thomas C; Trambley Joel; Odom Kris; Anderson Daniel C; Cowan Shannon; Bray Robert; Lin Angello; Hollenbaugh Diane; Aruffo Alejandro; Siadak Anthony W; Strobert Elizabeth; Hennigar Randall; Larsen Christian P
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
Transplantation 2002;74(7):933-40.
2002: Ahn J S; Konno A; Gebe J A; Aruffo A; Hamilton M J; Park Y H; Davis W C
Scavenger receptor cysteine-rich domains 9 and 11 of WC1 are receptors for the WC1 counter receptor.
Journal of leukocyte biology 2002;72(2):382-90.
2002: Hollenbaugh Diane; Aruffo Alejandro
Construction of immunoglobulin fusion proteins.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002;Chapter 10():Unit 10.19A.
2001: Aruffo A; Hollenbaugh D
Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease.
Current opinion in immunology 2001;13(6):683-6.
2001: Salih H R; Starling G C; Knauff M; Llewellyn M B; Davis P M; Pitts W J; Aruffo A; Kiener P A
Retinoic acid and vitamin E modulate expression and release of CD178 in carcinoma cells: consequences for induction of apoptosis in CD95-sensitive cells.
Experimental cell research 2001;270(2):248-58.
2001: Konno A; Ahn J S; Kitamura H; Hamilton M J; Gebe J A; Aruffo A; Davis W C
Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human.
Journal of leukocyte biology 2001;69(6):944-50.
2001: Hollenbaugh D; Aruffo A; Jones B; Linsley P
Use of monoclonal antibodies for expression cloning.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.18.
2001: Aruffo A
Transient expression of proteins using COS cells.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Chapter 4():Unit 4.7.
2000: Salih H R; Kosowski S G; Haluska V F; Starling G C; Loo D T; Lee F; Aruffo A A; Trail P A; Kiener P A
Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2903-10.
2000: Bowen M A; Aruffo A A; Bajorath J
Cell surface receptors and their ligands: in vitro analysis of CD6-CD166 interactions.
Proteins 2000;40(3):420-8.
2000: Sakata N; Hamelmann E; Siadak A W; Terada N; Gerwins P; Aruffo A; Johnson G L; Gelfand E W
Differential regulation of CD40-mediated human B cell responses by antibodies directed against different CD40 epitopes.
Cellular immunology 2000;201(2):109-23.
2000: Pospisil R; Silverman G J; Marti G E; Aruffo A; Bowen M A; Mage R G
CD5 is A potential selecting ligand for B-cell surface immunoglobulin: a possible role in maintenance and selective expansion of normal and malignant B cells.
Leukemia & lymphoma 2000;36(3-4):353-65.
2000: Gebe J A; Llewellyn M; Hoggatt H; Aruffo A
Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha.
Immunology 2000;99(1):78-86.
1999: Grimme H U; Termeer C C; Bennett K L; Weiss J M; Schöpf E; Aruffo A; Simon J C
Colocalization of basic fibroblast growth factor and CD44 isoforms containing the variably spliced exon v3 (CD44v3) in normal skin and in epidermal skin cancers.
The British journal of dermatology 1999;141(5):824-32.
1999: Smith L L; Greenfield B W; Aruffo A; Giachelli C M
CD44 is not an adhesive receptor for osteopontin.
Journal of cellular biochemistry 1999;73(1):20-30.
1999: Perez-Villar J J; Whitney G S; Bowen M A; Hewgill D H; Aruffo A A; Kanner S B
CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1.
Molecular and cellular biology 1999;19(4):2903-12.
1999: von Leoprechting A; van der Bruggen P; Pahl H L; Aruffo A; Simon J C
Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis.
Cancer research 1999;59(6):1287-94.
1999: Bowen M A; Aruffo A
Adhesion molecules, their receptors, and their regulation: analysis of CD6-activated leukocyte cell adhesion molecule (ALCAM/CD166) interactions.
Transplantation proceedings 1999;31(1-2):795-6.
1999: Wolff E A; Greenfield B; Taub D D; Murphy W J; Bennett K L; Aruffo A
Generation of artificial proteoglycans containing glycosaminoglycan-modified CD44. Demonstration of the interaction between rantes and chondroitin sulfate.
The Journal of biological chemistry 1999;274(4):2518-24.
1999: Greenfield B; Wang W C; Marquardt H; Piepkorn M; Wolff E A; Aruffo A; Bennett K L
Characterization of the heparan sulfate and chondroitin sulfate assembly sites in CD44.
The Journal of biological chemistry 1999;274(4):2511-7.
1998: Niimi M; Pearson T C; Larsen C P; Alexander D Z; Hollenbaugh D; Aruffo A; Linsley P S; Thomas E; Campbell K; Fanslow W C; Geha R S; Morris P J; Wood K J
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5331-7.
1998: Seyama K; Nonoyama S; Gangsaas I; Hollenbaugh D; Pabst H F; Aruffo A; Ochs H D
Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.
Blood 1998;92(7):2421-34.
1998: Loo D T; Kanner S B; Aruffo A
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction.
The Journal of biological chemistry 1998;273(36):23304-12.
1998: Wilson C B; Embree L J; Schowalter D; Albert R; Aruffo A; Hollenbaugh D; Linsley P; Kay M A
Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration.
Journal of virology 1998;72(9):7542-50.
1998: Bikah G; Lynd F M; Aruffo A A; Ledbetter J A; Bondada S
A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5.
International immunology 1998;10(8):1185-96.
1998: Elwood E T; Larsen C P; Cho H R; Corbascio M; Ritchie S C; Alexander D Z; Tucker-Burden C; Linsley P S; Aruffo A; Hollenbaugh D; Winn K J; Pearson T C
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.
Transplantation 1998;65(11):1422-8.
1998: Melero I; Bach N; Hellström K E; Aruffo A; Mittler R S; Chen L
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway.
European journal of immunology 1998;28(3):1116-21.
1998: Starling G C; Kiener P A; Aruffo A; Bajorath J
Analysis of the ligand binding site in Fas (CD95) by site-directed mutagenesis and comparison with TNFR and CD40.
Biochemistry 1998;37(11):3723-6.
1998: Nonoyama S; Etzioni A; Toru H; Ruggerie D P; Lewis D; Pollack S; Aruffo A; Yata J I; Ochs H D
Diminished expression of CD40 ligand may contribute to the defective humoral immunity in patients with MHC class II deficiency.
European journal of immunology 1998;28(2):589-98.
1998: Bajorath J; Greenfield B; Munro S B; Day A J; Aruffo A
Identification of CD44 residues important for hyaluronan binding and delineation of the binding site.
The Journal of biological chemistry 1998;273(1):338-43.
1997: Kobarg J; Whitney G S; Palmer D; Aruffo A; Bowen M A
Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains.
European journal of immunology 1997;27(11):2971-80.
1997: Piepkorn M; Hovingh P; Bennett K L; Aruffo A; Linker A
Chondroitin sulphate composition and structure in alternatively spliced CD44 fusion proteins.
The Biochemical journal 1997;327 ( Pt 2)():499-506.
1997: Aruffo A; Bowen M A; Patel D D; Haynes B F; Starling G C; Gebe J A; Bajorath J
CD6-ligand interactions: a paradigm for SRCR domain function?
Immunology today 1997;18(10):498-504.
1997: Bennett K L; Bradshaw J; Youngman T; Rodgers J; Greenfield B; Aruffo A; Linsley P S
Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain.
The Journal of biological chemistry 1997;272(43):26940-6.
1997: Zhu Q; Watanabe C; Liu T; Hollenbaugh D; Blaese R M; Kanner S B; Aruffo A; Ochs H D
Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype.
Blood 1997;90(7):2680-9.
1997: Marinier A; Martel A; Banville J; Bachand C; Remillard R; Lapointe P; Turmel B; Menard M; Harte W E; Wright J J; Todderud G; Tramposch K M; Bajorath J; Hollenbaugh D; Aruffo A
Sulfated galactocerebrosides as potential antiinflammatory agents.
Journal of medicinal chemistry 1997;40(20):3234-47.
1997: Todderud G; Nair X; Lee D; Alford J; Davern L; Stanley P; Bachand C; Lapointe P; Marinier A; Martel A; Menard M; Wright J J; Bajorath J; Hollenbaugh D; Aruffo A; Tramposch K M
BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1298-304.
1997: Skonier J E; Bodian D L; Emswiler J; Bowen M A; Aruffo A; Bajorath J
Mutational analysis of the CD6 ligand binding domain.
Protein engineering 1997;10(8):943-7.
1997: Clegg C H; Rulffes J T; Haugen H S; Hoggatt I H; Aruffo A; Durham S K; Farr A G; Hollenbaugh D
Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice.
International immunology 1997;9(8):1111-22.
1997: Skonier J E; Bowen M A; Aruffo A; Bajorath J
CD6 recognizes the neural adhesion molecule BEN.
Protein science : a publication of the Protein Society 1997;6(8):1768-70.
1997: Shuford W W; Klussman K; Tritchler D D; Loo D T; Chalupny J; Siadak A W; Brown T J; Emswiler J; Raecho H; Larsen C P; Pearson T C; Ledbetter J A; Aruffo A; Mittler R S
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
The Journal of experimental medicine 1997;186(1):47-55.
1997: Bowen M A; Bajorath J; D'Egidio M; Whitney G S; Palmer D; Kobarg J; Starling G C; Siadak A W; Aruffo A
Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding.
European journal of immunology 1997;27(6):1469-78.
1997: Melero I; Shuford W W; Newby S A; Aruffo A; Ledbetter J A; Hellström K E; Mittler R S; Chen L
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.
Nature medicine 1997;3(6):682-5.
1997: Golik J; Dickey J K; Todderud G; Lee D; Alford J; Huang S; Klohr S; Eustice D; Aruffo A; Agler M L
Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.
Journal of natural products 1997;60(4):387-9.
1997: Starling G C; Bajorath J; Emswiler J; Ledbetter J A; Aruffo A; Kiener P A
Identification of amino acid residues important for ligand binding to Fas.
The Journal of experimental medicine 1997;185(8):1487-92.
1997: Kay M A; Meuse L; Gown A M; Linsley P; Hollenbaugh D; Aruffo A; Ochs H D; Wilson C B
Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4686-91.
1997: Bodian D L; Skonier J E; Bowen M A; Neubauer M; Siadak A W; Aruffo A; Bajorath J
Identification of residues in CD6 which are critical for ligand binding.
Biochemistry 1997;36(9):2637-41.
1997: Loo D T; Chalupny N J; Bajorath J; Shuford W W; Mittler R S; Aruffo A
Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB.
The Journal of biological chemistry 1997;272(10):6448-56.
1997: Gebe J A; Kiener P A; Ring H Z; Li X; Francke U; Aruffo A
Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins.
The Journal of biological chemistry 1997;272(10):6151-8.
1997: Bowen M A; Whitney G S; Neubauer M; Starling G C; Palmer D; Zhang J; Nowak N J; Shows T B; Aruffo A
Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1149-56.
1997: Bajorath J; Aruffo A
Prediction of the three-dimensional structure of the human Fas receptor by comparative molecular modeling.
Journal of computer-aided molecular design 1997;11(1):3-8.
1997: Bajorath J; Aruffo A
Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40.
Proteins 1997;27(1):59-70.
1997: Starling G C; Llewellyn M B; Whitney G S; Aruffo A
The Ly-1.1 and Ly-1.2 epitopes of murine CD5 map to the membrane distal scavenger receptor cysteine-rich domain.
Tissue antigens 1997;49(1):1-6.
1997: Ledbetter J A; Francisco J A; Siegall C B; Gilliland L K; Hollenbaugh D; Aruffo A; Siadak A W; Mischel-Petty N; Grosmaire L S; Gordon M L; Brown T J; Moran-Davis P; Mittler R S; Kiener P A; Nadler S G
Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.
Critical reviews in immunology 1997;17(5-6):427-35.
1997: Stenkamp R E; Aruffo A; Bajorath J
Protein superfamily members as targets for computer modeling: the carbohydrate recognition domain of a macrophage lectin.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 1997;():432-40.
1996: Skonier J E; Bowen M A; Emswiler J; Aruffo A; Bajorath J
Mutational analysis of the CD6 binding site in activated leukocyte cell adhesion molecule.
Biochemistry 1996;35(47):14743-8.
1996: Denfeld R W; Hollenbaugh D; Fehrenbach A; Weiss J M; von Leoprechting A; Mai B; Voith U; Schöpf E; Aruffo A; Simon J C
CD40 is functionally expressed on human keratinocytes.
European journal of immunology 1996;26(10):2329-34.
1996: Biancone L; Bowen M A; Lim A; Aruffo A; Andres G; Stamenkovic I
Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes.
The Journal of experimental medicine 1996;184(3):811-9.
1996: Skonier J E; Bowen M A; Emswiler J; Aruffo A; Bajorath J
Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.
Biochemistry 1996;35(38):12287-91.
1996: Cunningham M D; Seachord C; Ratcliffe K; Bainbridge B; Aruffo A; Darveau R P
Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14.
Infection and immunity 1996;64(9):3601-8.
1996: Liles W C; Kiener P A; Ledbetter J A; Aruffo A; Klebanoff S J
Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.
The Journal of experimental medicine 1996;184(2):429-40.
1996: Kahn S J; Wleklinski M; Ezekowitz R A; Coder D; Aruffo A; Farr A
The major surface glycoprotein of Trypanosoma cruzi amastigotes are ligands of the human serum mannose-binding protein.
Infection and immunity 1996;64(7):2649-56.
1996: Bowen M A; Bajorath J; Siadak A W; Modrell B; Malacko A R; Marquardt H; Nadler S G; Aruffo A
The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry.
The Journal of biological chemistry 1996;271(29):17390-6.
1996: Larsen C P; Elwood E T; Alexander D Z; Ritchie S C; Hendrix R; Tucker-Burden C; Cho H R; Aruffo A; Hollenbaugh D; Linsley P S; Winn K J; Pearson T C
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.
Nature 1996;381(6581):434-8.
1996: Starling G C; Whitney G S; Siadak A W; Llewellyn M B; Bowen M A; Farr A G; Aruffo A A
Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction.
European journal of immunology 1996;26(4):738-46.
1996: Bajorath J; Seyama K; Nonoyama S; Ochs H D; Aruffo A
Classification of mutations in the human CD40 ligand, gp39, that are associated with X-linked hyper IgM syndrome.
Protein science : a publication of the Protein Society 1996;5(3):531-4.
1996: Bartolazzi A; Nocks A; Aruffo A; Spring F; Stamenkovic I
Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan.
The Journal of cell biology 1996;132(6):1199-208.
1996: Bajorath J; Aruffo A
Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.
Protein science : a publication of the Protein Society 1996;5(2):240-7.
1996: Nelson A J; Dunn R J; Peach R; Aruffo A; Farr A G
The murine homolog of human Ep-CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells.
European journal of immunology 1996;26(2):401-8.
1996: Larsen C P; Alexander D Z; Hollenbaugh D; Elwood E T; Ritchie S C; Aruffo A; Hendrix R; Pearson T C
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.
Transplantation 1996;61(1):4-9.
1995: Hollenbaugh D; Douthwright J; McDonald V; Aruffo A
Cleavable CD40Ig fusion proteins and the binding to sgp39.
Journal of immunological methods 1995;188(1):1-7.
1995: Schubert L A; King G; Cron R Q; Lewis D B; Aruffo A; Hollenbaugh D
The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation.
The Journal of biological chemistry 1995;270(50):29624-7.
1995: Bennett K L; Modrell B; Greenfield B; Bartolazzi A; Stamenkovic I; Peach R; Jackson D G; Spring F; Aruffo A
Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons.
The Journal of cell biology 1995;131(6 Pt 1):1623-33.
1995: Kahn S; Wleklinski M; Aruffo A; Farr A; Coder D; Kahn M
Trypanosoma cruzi amastigote adhesion to macrophages is facilitated by the mannose receptor.
The Journal of experimental medicine 1995;182(5):1243-58.
1995: Kiener P A; Moran-Davis P; Rankin B M; Wahl A F; Aruffo A; Hollenbaugh D
Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4917-25.
1995: Todderud G; Alford J; Aruffo A; Tramposch K M
Phorbol ester-induced upregulation of polymorphonuclear leukocyte P-selectin ligand expression.
Cellular immunology 1995;166(1):16-24.
1995: Bajorath J; Aruffo A
A template for generation and comparison of three-dimensional selectin models.
Biochemical and biophysical research communications 1995;216(3):1018-23.
1995: Chalupny N J; Aruffo A; Esselstyn J M; Chan P Y; Bajorath J; Blake J; Gilliland L K; Ledbetter J A; Tepper M A
Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains.
European journal of immunology 1995;25(10):2978-84.
1995: Law C L; Aruffo A; Chandran K A; Doty R T; Clark E A
Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3368-76.
1995: Edwards C P; Farr A G; Marken J S; Nelson A; Bajorath J; Hellström K E; Hellström I; Aruffo A
Cloning of the murine counterpart of the tumor-associated antigen H-L6: epitope mapping of the human and murine L6 antigens.
Biochemistry 1995;34(39):12653-60.
1995: Peach R J; Bajorath J; Naemura J; Leytze G; Greene J; Aruffo A; Linsley P S
Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
The Journal of biological chemistry 1995;270(36):21181-7.
1995: Bajorath J; Bowen M A; Aruffo A
Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.
Protein science : a publication of the Protein Society 1995;4(8):1644-7.
1995: Bajorath J; Marken J S; Chalupny N J; Spoon T L; Siadak A W; Gordon M; Noelle R J; Hollenbaugh D; Aruffo A
Analysis of gp39/CD40 interactions using molecular models and site-directed mutagenesis.
Biochemistry 1995;34(31):9884-92.
1995: Whitney G S; Starling G C; Bowen M A; Modrell B; Siadak A W; Aruffo A
The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.
The Journal of biological chemistry 1995;270(31):18187-90.
1995: Hollenbaugh D; Mischel-Petty N; Edwards C P; Simon J C; Denfeld R W; Kiener P A; Aruffo A
Expression of functional CD40 by vascular endothelial cells.
The Journal of experimental medicine 1995;182(1):33-40.
1995: Culouscou J M; Carlton G W; Aruffo A
HER4 receptor activation and phosphorylation of Shc proteins by recombinant heregulin-Fc fusion proteins.
The Journal of biological chemistry 1995;270(21):12857-63.
1995: Bartolazzi A; Jackson D; Bennett K; Aruffo A; Dickinson R; Shields J; Whittle N; Stamenkovic I
Regulation of growth and dissemination of a human lymphoma by CD44 splice variants.
Journal of cell science 1995;108 ( Pt 4)():1723-33.
1995: Hollenbaugh D; Aruffo A; Senter P D
Effects of chemical modification on the binding activities of P-selectin mutants.
Biochemistry 1995;34(16):5678-84.
1995: Patel D D; Wee S F; Whichard L P; Bowen M A; Pesando J M; Aruffo A; Haynes B F
Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells.
The Journal of experimental medicine 1995;181(4):1563-8.
1995: Darveau R P; Cunningham M D; Bailey T; Seachord C; Ratcliffe K; Bainbridge B; Dietsch M; Page R C; Aruffo A
Ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and promote neutrophil adhesion.
Infection and immunity 1995;63(4):1311-7.
1995: Bennett K L; Jackson D G; Simon J C; Tanczos E; Peach R; Modrell B; Stamenkovic I; Plowman G; Aruffo A
CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.
The Journal of cell biology 1995;128(4):687-98.
1995: Bajorath J; Chalupny N J; Marken J S; Siadak A W; Skonier J; Gordon M; Hollenbaugh D; Noelle R J; Ochs H D; Aruffo A
Identification of residues on CD40 and its ligand which are critical for the receptor-ligand interaction.
Biochemistry 1995;34(6):1833-44.
1995: Whitney G; Bowen M; Neubauer M; Aruffo A
Cloning and characterization of murine CD6.
Molecular immunology 1995;32(1):89-92.
1995: Nonoyama S; Penix L A; Edwards C P; Lewis D B; Ito S; Aruffo A; Wilson C B; Ochs H D
Diminished expression of CD40 ligand by activated neonatal T cells.
The Journal of clinical investigation 1995;95(1):66-75.
1995: Bajorath J; Stenkamp R; Aruffo A
Comparison of a protein model with its X-ray structure: the ligand binding domain of E-selectin.
Bioconjugate chemistry 1995;6(1):3-6.
1995: Darveau R P; Cunningham M D; Seachord C L; Page R C; Aruffo A
The ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and neutrophil adhesion.
Progress in clinical and biological research 1995;392():69-78.
1994: Bajorath J; Aruffo A
Molecular model of the extracellular lectin-like domain in CD69.
The Journal of biological chemistry 1994;269(51):32457-63.
1994: Wee S; Wang W C; Farr A G; Nelson A J; Patel D D; Haynes B F; Linsley P S; Aruffo A
Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues.
Cellular immunology 1994;158(2):353-64.
1994: Ledbetter J A; Grosmaire L S; Hollenbaugh D; Aruffo A; Nadler S G
Agonistic and antagonistic properties of CD40 mAb G28-5 are dependent on binding valency.
Circulatory shock 1994;44(2):67-72.
1994: Ochs H D; Hollenbaugh D; Aruffo A
The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency.
Seminars in immunology 1994;6(5):337-41.
1994: Kanner S B; Aruffo A; Chan P Y
Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10484-7.
1994: Dietsch M T; Chan P Y; Kanner S B; Gilliland L K; Ledbetter J A; Linsley P S; Aruffo A
Coengagement of CD2 with LFA-1 or VLA-4 by bispecific ligand fusion proteins primes T cells to respond more effectively to T cell receptor-dependent signals.
Journal of leukocyte biology 1994;56(4):444-52.
1994: Chan P Y; Kanner S B; Whitney G; Aruffo A
A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.
The Journal of biological chemistry 1994;269(32):20567-74.
1994: Hollenbaugh D; Wu L H; Ochs H D; Nonoyama S; Grosmaire L S; Ledbetter J A; Noelle R J; Hill H; Aruffo A
The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1.
The Journal of clinical investigation 1994;94(2):616-22.
1994: Bartolazzi A; Peach R; Aruffo A; Stamenkovic I
Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.
The Journal of experimental medicine 1994;180(1):53-66.
1994: Liu J; Modrell B; Aruffo A; Scharnowske S; Shoyab M
Interactions between oncostatin M and the IL-6 signal transducer, gp130.
Cytokine 1994;6(3):272-8.
1994: Bajorath J; Aruffo A
Three-dimensional protein models: insights into structure, function, and molecular interactions.
Bioconjugate chemistry 1994;5(3):173-81.
1994: Hollenbaugh D; Ochs H D; Noelle R J; Ledbetter J A; Aruffo A
The role of CD40 and its ligand in the regulation of the immune response.
Immunological reviews 1994;138():23-37.
1994: Ochs H D; Hollenbaugh D; Aruffo A
The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency.
Research in immunology 1994;145(3):210-5; discussion 244-9.
1994: Damle N K; Klussman K; Leytze G; Myrdal S; Aruffo A; Ledbetter J A; Linsley P S
Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2686-97.
1994: Marken J S; Bajorath J; Edwards C P; Farr A G; Schieven G L; Hellström I; Hellström K E; Aruffo A
Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody.
The Journal of biological chemistry 1994;269(10):7397-401.
1994: Guo Y J; Wong J H; Lin S C; Aruffo A; Stamenkovic I; Sy M S
Disruption of T lymphocyte reappearance in anti-Thy-1-treated animals in vivo with soluble CD44 and L-selectin molecules.
Cellular immunology 1994;154(1):202-18.
1994: Maresh G A; Marken J S; Neubauer M; Aruffo A; Hellström I; Hellström K E; Marquardt H
Cloning and expression of the gene for the melanoma-associated ME20 antigen.
DNA and cell biology 1994;13(2):87-95.
1994: Bajorath J; Hollenbaugh D; King G; Harte W; Eustice D C; Darveau R P; Aruffo A
CD62/P-selectin binding sites for myeloid cells and sulfatides are overlapping.
Biochemistry 1994;33(6):1332-9.
1994: Farrington M; Grosmaire L S; Nonoyama S; Fischer S H; Hollenbaugh D; Ledbetter J A; Noelle R J; Aruffo A; Ochs H D
CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):1099-103.
1994: Aruffo A; Hollenbaugh D; Wu L H; Ochs H D
The molecular basis of X-linked agammaglobulinemia, hyper-IgM syndrome, and severe combined immunodeficiency in humans.
Current opinion in hematology 1994;1(1):12-8.
1994: Stamenkovic I; Aruffo A
Hyaluronic acid receptors.
Methods in enzymology 1994;245():195-216.
1993: Ochs H D; Aruffo A
Advances in X-linked immunodeficiency diseases.
Current opinion in pediatrics 1993;5(6):684-91.
1993: Whitney G S; Chan P Y; Blake J; Cosand W L; Neubauer M G; Aruffo A; Kanner S B
Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
DNA and cell biology 1993;12(9):823-30.
1993: Deans J P; Schieven G L; Shu G L; Valentine M A; Gilliland L A; Aruffo A; Clark E A; Ledbetter J A
Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4494-504.
1993: Bajorath J; Stenkamp R; Aruffo A
Knowledge-based model building of proteins: concepts and examples.
Protein science : a publication of the Protein Society 1993;2(11):1798-810.
1993: Ochs H D; Nonoyama S; Farrington M L; Fischer S H; Aruffo A
The role of adhesion molecules in the regulation of antibody responses.
Seminars in hematology 1993;30(4 Suppl 4):72-9; discussion 80-1.
1993: Edwards C P; Aruffo A
Current applications of COS cell based transient expression systems.
Current opinion in biotechnology 1993;4(5):558-63.
1993: Damle N K; Klussman K; Leytze G; Aruffo A; Linsley P S; Ledbetter J A
Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2368-79.
1993: Nonoyama S; Hollenbaugh D; Aruffo A; Ledbetter J A; Ochs H D
B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells.
The Journal of experimental medicine 1993;178(3):1097-102.
1993: Peach R J; Hollenbaugh D; Stamenkovic I; Aruffo A
Identification of hyaluronic acid binding sites in the extracellular domain of CD44.
The Journal of cell biology 1993;122(1):257-64.
1993: Chalupny N J; Kanner S B; Schieven G L; Wee S F; Gilliland L K; Aruffo A; Ledbetter J A
Tyrosine phosphorylation of CD19 in pre-B and mature B cells.
The EMBO journal 1993;12(7):2691-6.
1993: Ledbetter J A; Deans J P; Aruffo A; Grosmaire L S; Kanner S B; Bolen J B; Schieven G L
CD4, CD8 and the role of CD45 in T-cell activation.
Current opinion in immunology 1993;5(3):334-40.
1993: Dietsch M T; Smith V F; Cosand W L; Damle N K; Ledbetter J A; Linsley P S; Aruffo A
Bispecific receptor globulins, novel tools for the study of cellular interactions. Preparation and characterization of an E-selectin/P-selectin bispecific receptor globulin.
Journal of immunological methods 1993;162(1):123-32.
1993: Damle N K; Klussman K; Leytze G; Ochs H D; Aruffo A; Linsley P S; Ledbetter J A
Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7.
Cellular immunology 1993;148(1):144-56.
1993: Hollenbaugh D; Bajorath J; Stenkamp R; Aruffo A
Interaction of P-selectin (CD62) and its cellular ligand: analysis of critical residues.
Biochemistry 1993;32(12):2960-6.
1993: Aruffo A; Farrington M; Hollenbaugh D; Li X; Milatovich A; Nonoyama S; Bajorath J; Grosmaire L S; Stenkamp R; Neubauer M
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
Cell 1993;72(2):291-300.
1993: Wee S; Schieven G L; Kirihara J M; Tsu T T; Ledbetter J A; Aruffo A
Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors.
The Journal of experimental medicine 1993;177(1):219-23.
1992: Hollenbaugh D; Grosmaire L S; Kullas C D; Chalupny N J; Braesch-Andersen S; Noelle R J; Stamenkovic I; Ledbetter J A; Aruffo A
The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.
The EMBO journal 1992;11(12):4313-21.
1992: Aruffo A; Kanner S B; Sgroi D; Ledbetter J A; Stamenkovic I
CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10242-6.
1992: Farr A G; Berry M L; Kim A; Nelson A J; Welch M P; Aruffo A
Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues.
The Journal of experimental medicine 1992;176(5):1477-82.
1992: Chalupny N J; Peach R; Hollenbaugh D; Ledbetter J A; Farr A G; Aruffo A
T-cell activation molecule 4-1BB binds to extracellular matrix proteins.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10360-4.
1992: Damle N K; Klussman K; Linsley P S; Aruffo A; Ledbetter J A
Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2541-8.
1992: Fell H P; Gayle M A; Yelton D; Lipsich L; Schieven G L; Marken J S; Aruffo A; Hellström K E; Hellström I; Bajorath J
Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site.
The Journal of biological chemistry 1992;267(22):15552-8.
1992: Liu J; Modrell B; Aruffo A; Marken J S; Taga T; Yasukawa K; Murakami M; Kishimoto T; Shoyab M
Interleukin-6 signal transducer gp130 mediates oncostatin M signaling.
The Journal of biological chemistry 1992;267(24):16763-6.
1992: Todderud G; Alford J; Millsap K A; Aruffo A; Tramposch K M
PMN binding to P-selectin is inhibited by sulfatide.
Journal of leukocyte biology 1992;52(1):85-8.
1992: Damle N K; Klussman K; Dietsch M T; Mohagheghpour N; Aruffo A
GMP-140 (P-selectin/CD62) binds to chronically stimulated but not resting CD4+ T lymphocytes and regulates their production of proinflammatory cytokines.
European journal of immunology 1992;22(7):1789-93.
1992: Gilliland L K; Schieven G L; Norris N A; Kanner S B; Aruffo A; Ledbetter J A
Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLC gamma 1 SH2 domains.
The Journal of biological chemistry 1992;267(19):13610-6.
1992: Hollenbaugh D; Chalupny N J; Aruffo A
Recombinant globulins: novel research tools and possible pharmaceuticals.
Current opinion in immunology 1992;4(2):216-9.
1992: Marken J S; Schieven G L; Hellström I; Hellström K E; Aruffo A
Cloning and expression of the tumor-associated antigen L6.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3503-7.
1992: Kanner S B; Damle N K; Blake J; Aruffo A; Ledbetter J A
CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2023-9.
1992: Damle N K; Klussman K; Linsley P S; Aruffo A
Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):1985-92.
1992: Aruffo A; Dietsch M T; Wan H; Hellström K E; Hellström I
Granule membrane protein 140 (GMP140) binds to carcinomas and carcinoma-derived cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2292-6.
1992: Stamenkovic I; Sgroi D; Aruffo A
CD22 binds to alpha-2,6-sialyltransferase-dependent epitopes on COS cells.
Cell 1992;68(6):1003-4.
1992: Damle N K; Klussman K; Aruffo A
Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):665-71.
1991: Lin H Y; Harris T L; Flannery M S; Aruffo A; Kaji E H; Gorn A; Kolakowski L F; Lodish H F; Goldring S R
Expression cloning of an adenylate cyclase-coupled calcitonin receptor.
Science (New York, N.Y.) 1991;254(5034):1022-4.
1991: Aruffo A; Kolanus W; Walz G; Fredman P; Seed B
CD62/P-selectin recognition of myeloid and tumor cell sulfatides.
Cell 1991;67(1):35-44.
1991: Aruffo A
Expression cloning systems.
Current opinion in biotechnology 1991;2(5):735-41.
1991: Stamenkovic I; Sgroi D; Aruffo A; Sy M S; Anderson T
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells.
Cell 1991;66(6):1133-44.
1991: Stamenkovic I; Aruffo A; Amiot M; Seed B
The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.
The EMBO journal 1991;10(2):343-8.
1991: Lin H Y; Harris T L; Flannery M S; Aruffo A; Kaji E H; Gorn A; Kolakowski L F; Yamin M; Lodish H F; Goldring S R
Expression cloning and characterization of a porcine renal calcitonin receptor.
Transactions of the Association of American Physicians 1991;104():265-72.
1990: Walz G; Aruffo A; Kolanus W; Bevilacqua M; Seed B
Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells.
Science (New York, N.Y.) 1990;250(4984):1132-5.
1990: Aruffo A; Stamenkovic I; Melnick M; Underhill C B; Seed B
CD44 is the principal cell surface receptor for hyaluronate.
Cell 1990;61(7):1303-13.

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