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Guttorm Haraldsen

Research Profile

Anatomy

Chemicals & Drugs

Living Beings

Mouse

Procedures

Physiology

Immunity, Mucosal

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Publications

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Jürgen Pollheimer; Sigrid S Skånland; Jon Sponheim; Eirik Sundlisaeter; Olav Sundnes; Kjetil Taskén; Morten Vatn; Junbai Wang; Johanna Bodin; Mari Johanna Brox; Reidunn J Edelmann; Guttorm Haraldsen; Monika Kasprzycka; Axel M Küchler; Tamara Loos; Johanna Hol
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells.
Eirik Sundlisaeter; Irina A Udalova; Miriam Weiss; Reidunn J Edelmann; Johanna Hol; Monika Kasprzycka; Axel M Küchler; Kim S Midwood; Jon Sponheim; Guttorm Haraldsen
The alarmin IL-33 is a notch target in quiescent endothelial cells.
Johanna Hol; Monika Kasprzycka; Kari Otterdal; Turid M Pedersen; Trine Ranheim; espen stang; Unni M Breland; Kathrine Hagelsteen; Bente Halvorsen; Guttorm Haraldsen; Pål Aukrust
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.

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All Publications

2013: Jürgen Pollheimer; Sigrid S Skånland; Jon Sponheim; Eirik Sundlisaeter; Olav Sundnes; Kjetil Taskén; Morten Vatn; Junbai Wang; Johanna Bodin; Mari Johanna Brox; Reidunn J Edelmann; Guttorm Haraldsen; Monika Kasprzycka; Axel M Küchler; Tamara Loos; Johanna Hol
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(2):e47-55.
2012: Eirik Sundlisaeter; Irina A Udalova; Miriam Weiss; Reidunn J Edelmann; Johanna Hol; Monika Kasprzycka; Axel M Küchler; Kim S Midwood; Jon Sponheim; Guttorm Haraldsen
The alarmin IL-33 is a notch target in quiescent endothelial cells.
The American journal of pathology 2012;181(3):1099-111.
2012: Johanna Hol; Monika Kasprzycka; Kari Otterdal; Turid M Pedersen; Trine Ranheim; espen stang; Unni M Breland; Kathrine Hagelsteen; Bente Halvorsen; Guttorm Haraldsen; Pål Aukrust
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.
PloS one 2012;7(7):e40673.
2011: Jürgen Pollheimer; Johanna Prast; Leila Saleh; Katarzyna Biadasiewicz; Valerie Fock; Sandra Haider; Guttorm Haraldsen; Peter Haslinger; Kora Hirtenlehner-Ferber; Reidunn Jetne-Edelmann; Martin Knöfler
Endostatin suppresses IGF-II-mediated signaling and invasion of human extravillous trophoblasts.
Endocrinology 2011;152(11):4431-42.
2011: Ole Audun Werner Haabeth; Kristina Berg Lorvik; Clara Hammarström; Ian M Donaldson; Guttorm Haraldsen; Bjarne Bogen; Alexandre Corthay
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.
Nature communications 2011;2():240.
2010: Jon Sponheim; Jürgen Pollheimer; Trine Olsen; Johanna Balogh; Clara Hammarström; Tamara Loos; Monika Kasprzycka; Dag Reidar Sørensen; Hogne Røed Nilsen; Axel M Küchler; Morten H Vatn; Guttorm Haraldsen
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.
The American journal of pathology 2010;177(6):2804-15.
2010: B Mikalsen; B Fosby; J Wang; C Hammarström; H Bjaerke; M Lundström; M Kasprzycka; Helge Scott; Pål-Dag Line; Guttorm Haraldsen
Genome-wide transcription profile of endothelial cells after cardiac transplantation in the rat.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(7):1534-44.
2010: Johanna Hol; Linn Wilhelmsen; Guttorm Haraldsen
The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies.
Journal of leukocyte biology 2010;87(3):501-8.
2010: Camilla Norrmén; Wouter Vandevelde; Annelii Ny; Pipsa Saharinen; Massimiliano Gentile; Guttorm Haraldsen; Pauli Puolakkainen; Eugene Lukanidin; Mieke Dewerchin; Kari Alitalo; Tatiana V Petrova
Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.
Blood 2010;115(4):906-9.
2009: Godfrey E Etokebe; Axel M Küchler; Guttorm Haraldsen; Maria Landin; Harald Osmundsen; Zlatko Dembic
Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds.
Archives of oral biology 2009;54(11):1002-7.
2009: Johanna Hol; Axel M Küchler; Finn-Eirik Johansen; Bjørn Dalhus; Guttorm Haraldsen; Inger Oynebråten
Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies.
The Journal of biological chemistry 2009;284(35):23532-9.
2009: Guttorm Haraldsen; Johanna Balogh; Jürgen Pollheimer; Jon Sponheim; Axel M Küchler
Interleukin-33 - cytokine of dual function or novel alarmin?
Trends in immunology 2009;30(5):227-33.
2008: Axel M Küchler; Jürgen Pollheimer; Johanna Balogh; Jon Sponheim; Linda Manley; Dag R Sorensen; Paula M De Angelis; Helge Scott; Guttorm Haraldsen
Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.
The American journal of pathology 2008;173(4):1229-42.
2008: Marit Saethre; Mårten Schneider; John D Lambris; Paola Magotti; Guttorm Haraldsen; Jörg D Seebach; Tom Eirik Mollnes
Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6346-53.
2008: Unni M Breland; Bente Halvorsen; Johanna Hol; Erik Øie; Gabrielle Paulsson-Berne; Arne Yndestad; Camilla Smith; Kari Otterdal; Ulf Hedin; Torgun Waehre; Wiggo J Sandberg; Stig S Frøland; Guttorm Haraldsen; Lars Gullestad; Jan Kristian Damås; Göran K Hansson; Pål Aukrust
A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):1005-11.
2007: Dag K Skovseth; Axel M Küchler; Guttorm Haraldsen
The HUVEC/Matrigel assay: an in vivo assay of human angiogenesis suitable for drug validation.
Methods in molecular biology (Clifton, N.J.) 2007;360():253-68.
2006: Guttorm Haraldsen; Antal Rot
Coy decoy with a new ploy: interceptor controls the levels of homeostatic chemokines.
European journal of immunology 2006;36(7):1659-61.
2006: Marit Saethre; Tor Lea; Merethe S Borgen; Arnt E Fiane; Terje E Michaelsen; Erik Thorsby; Guttorm Haraldsen; Tom Eirik Mollnes
Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation.
Xenotransplantation 2006;13(3):215-23.
2005: Inger Øynbråten; Nicolas Barois; Kathrine Hagelsteen; Finn-Eirik Johansen; Oddmund Bakke; Guttorm Haraldsen
Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5358-69.
2005: Arnt E Fiane; Thor Ueland; Svein Simonsen; Helge Scott; Knut Endresen; Lars Gullestad; Odd Geiran; Guttorm Haraldsen; Lars Heggelund; Arne K Andreassen; Ragnhild Wergeland; Stig S Frøland; Pål Aukrust; Tom Eirik Mollnes
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation.
European heart journal 2005;26(16):1660-5.
2005: Harald Carlsen; Guttorm Haraldsen; Per Brandtzaeg; Espen S Baekkevold
Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules.
Blood 2005;106(2):444-6.
2005: Espen S Baekkevold; Marc-André Wurbel; Pia Kivisäkk; Clare M Wain; Christine A Power; Guttorm Haraldsen; James J Campbell
A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations.
The Journal of experimental medicine 2005;201(7):1045-51.
2005: Alexandre Corthay; Dag K Skovseth; Katrin U Lundin; Egil Røsjø; Hilde Omholt; Peter O Hofgaard; Guttorm Haraldsen; Bjarne Bogen
Primary antitumor immune response mediated by CD4+ T cells.
Immunity 2005;22(3):371-83.
2005: Shuo-Wang Qiao; Justin Piper; Guttorm Haraldsen; Inger Oynebråten; Burkhard Fleckenstein; Oyvind Molberg; Chaitan Khosla; Ludvig M Sollid
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1657-63.
2005: Dag K Skovseth; Marjan J T Veuger; Dag R Sorensen; Paula M De Angelis; Guttorm Haraldsen
Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo.
Blood 2005;105(3):1044-51.
2004: Harald Carlsen; Espen S Baekkevold; Craig Morton; Guttorm Haraldsen; Per Brandtzaeg
Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis.
Blood 2004;104(10):3021-7.
2004: Inger Øynbråten; Oddmund Bakke; Per Brandtzaeg; Finn-Eirik Johansen; Guttorm Haraldsen
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
Blood 2004;104(2):314-20.
2004: Delphine-Armelle Lacorre; Espen S Baekkevold; Ignacio Garrido; Per Brandtzaeg; Guttorm Haraldsen; François Amalric; Jean-Philippe Girard
Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment.
Blood 2004;103(11):4164-72.
2003: Jen-Tsan Chi; Howard Y Chang; Guttorm Haraldsen; Frode L Jahnsen; Olga G Troyanskaya; Dustin S Chang; Zhen Wang; Stanley G Rockson; Matt van de Rijn; David Botstein; Patrick O Brown
Endothelial cell diversity revealed by global expression profiling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10623-8.
2003: Espen S Baekkevold; Myriam Roussigné; Takeshi Yamanaka; Finn-Eirik Johansen; Frode L Jahnsen; François Amalric; Per Brandtzaeg; Monique Erard; Guttorm Haraldsen; Jean-Philippe Girard
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules.
The American journal of pathology 2003;163(1):69-79.
2002: Inger Nina Farstad; Fabio Malavasi; Guttorm Haraldsen; Henrik S Huitfeldt; Per Brandtzaeg
CD38 is a marker of human lacteals.
Virchows Archiv : an international journal of pathology 2002;441(6):605-13.
2002: Marit Saethre; Una Ø Sølvik; Guttorm Haraldsen; Arnt E Fiane; Eva Boretti; Erik Thorsby; Jeffrey L Platt; Tom Eirik Mollnes
Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies.
Xenotransplantation 2002;9(5):350-8.
2002: Harald Carlsen; Espen S Baekkevold; Finn-Eirik Johansen; Guttorm Haraldsen; Per Brandtzaeg
B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue.
Gut 2002;51(3):364-71.
2002: Dag K Skovseth; Takeshi Yamanaka; Per Brandtzaeg; Eugene C Butcher; Guttorm Haraldsen
Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice.
The American journal of pathology 2002;160(5):1629-37.
2001: U Ø Sølvik; Guttorm Haraldsen; Arnt E Fiane; Eva Boretti; John D Lambris; Michael Fung; Erik Thorsby; Tom Eirik Mollnes
Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated.
Transplantation 2001;72(12):1967-73.
2001: Espen S Baekkevold; Takeshi Yamanaka; Roger Palframan; Harald Carlsen; F P Reinholt; Ulrich H von Andrian; Per Brandtzaeg; Guttorm Haraldsen
The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment.
The Journal of experimental medicine 2001;193(9):1105-12.
2001: U O Sølvik; Guttorm Haraldsen; Arnt E Fiane; Eva Boretti; Erik Thorsby; Tom Eirik Mollnes
C1-inhibitor attenuates human serum induced E-selectin expression of pig aortic endothelial cells.
Transplantation proceedings 2001;33(1-2):789-90.
2000: Eric J Kunkel; James J Campbell; Guttorm Haraldsen; Junliang Pan; Judie Boisvert; Arthur I Roberts; Ellen C Ebert; Mark A Vierra; Stuart Goodman; Mark C Genovese; Andrew J Wardlaw; Harry B Greenberg; Christina M Parker; Eugene C Butcher; David Andrew; William W Agace
Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity.
The Journal of experimental medicine 2000;192(5):761-8.
2000: H Sindre; Guttorm Haraldsen; S Beck; Kjetil Hestdal; Dag Kvale; Per Brandtzaeg; Miklos Degré; Halvor Rollag
Human intestinal endothelium shows high susceptibility to cytomegalovirus and altered expression of adhesion molecules after infection.
Scandinavian journal of immunology 2000;51(4):354-60.
1999: Jean-Philippe Girard; Espen S Baekkevold; Takeshi Yamanaka; Guttorm Haraldsen; Per Brandtzaeg; François Amalric
Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization.
The American journal of pathology 1999;155(6):2043-55.
1999: James J Campbell; Guttorm Haraldsen; Junliang Pan; J Rottman; S Qin; Paul D Ponath; David Andrew; R Warnke; N Ruffing; N Kassam; Lijun Wu; Eugene C Butcher
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.
Nature 1999;400(6746):776-80.
1999: Per Brandtzaeg; Inger Nina Farstad; Guttorm Haraldsen
Regional specialization in the mucosal immune system: primed cells do not always home along the same track.
Immunology today 1999;20(6):267-77.
1999: Espen S Baekkevold; Frode L Jahnsen; Finn-Eirik Johansen; Oddmund Bakke; Gustav Gaudernack; Per Brandtzaeg; Guttorm Haraldsen
Culture characterization of differentiated high endothelial venule cells from human tonsils.
Laboratory investigation; a journal of technical methods and pathology 1999;79(3):327-36.
1998: J O Utgaard; Frode L Jahnsen; Arne Bakka; Per Brandtzaeg; Guttorm Haraldsen
Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells.
The Journal of experimental medicine 1998;188(9):1751-6.
1998: EM Nilsen; Finn-Eirik Johansen; Frode L Jahnsen; Knut E A Lundin; T Scholz; Per Brandtzaeg; Guttorm Haraldsen
Cytokine profiles of cultured microvascular endothelial cells from the human intestine.
Gut 1998;42(5):635-42.
1998: Guttorm Haraldsen; Ludvig M Sollid; Oddmund Bakke; Inger Nina Farstad; Dag Kvale; Jarle Norstein; espen stang; Per Brandtzaeg
Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells.
Gastroenterology 1998;114(4):649-56.
1998: Per Brandtzaeg; Inger Nina Farstad; Guttorm Haraldsen; Frode L Jahnsen
Cellular and molecular mechanisms for induction of mucosal immunity.
Developments in biological standardization 1998;92():93-108.
1997: Per Brandtzaeg; Frode L Jahnsen; Inger Nina Farstad; Guttorm Haraldsen
Mucosal immunology of the upper airways: an overview.
Annals of the New York Academy of Sciences 1997;830():1-18.
1997: I B Natvig; Finn-Eirik Johansen; Tommy W Nordeng; Guttorm Haraldsen; Per Brandtzaeg
Mechanism for enhanced external transfer of dimeric IgA over pentameric IgM: studies of diffusion, binding to the human polymeric Ig receptor, and epithelial transcytosis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4330-40.
1997: Frode L Jahnsen; Per Brandtzaeg; Rolf Haye; Guttorm Haraldsen
Expression of functional VCAM-1 by cultured nasal polyp-derived microvascular endothelium.
The American journal of pathology 1997;150(6):2113-23.
1997: Per Brandtzaeg; Audun Elnaes Berstad; Inger Nina Farstad; Guttorm Haraldsen; Lars Helgeland; Frode L Jahnsen; Finn-Eirik Johansen; I B Natvig; EM Nilsen; Jarle Rugtveit
Mucosal immunity--a major adaptive defence mechanism.
Behring Institute Mitteilungen 1997;(98):1-23.
1997: Per Brandtzaeg; Guttorm Haraldsen; Jarle Rugtveit
Immunopathology of human inflammatory bowel disease.
Springer seminars in immunopathology 1997;18(4):555-89.
1996: Guttorm Haraldsen; Dag Kvale; Bjørn Lien; Inger Nina Farstad; P Brandtzaeg
Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2558-65.
1995: Jarle Rugtveit; Guttorm Haraldsen; A K Høgåsen; Arne Bakka; Per Brandtzaeg; Helge Scott
Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14+L1+ monocyte derived cells.
Gut 1995;37(3):367-73.
1995: Guttorm Haraldsen; Jarle Rugtveit; Dag Kvale; T Scholz; W A Muller; T Hovig; Per Brandtzaeg
Isolation and longterm culture of human intestinal microvascular endothelial cells.
Gut 1995;37(2):225-34.
1995: Frode L Jahnsen; Guttorm Haraldsen; J P Aanesen; Rolf Haye; Per Brandtzaeg
Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps.
American journal of respiratory cell and molecular biology 1995;12(6):624-32.
1994: Frode L Jahnsen; Guttorm Haraldsen; Jarle Rugtveit; Trond S Halstensen; Per Brandtzaeg
Differential interference contrast microscopy combined with immunofluorescence: a new method to phenotype eosinophils in situ.
Journal of immunological methods 1994;173(1):77-91.