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Hideyoshi Harashima
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51
Kamiya, Hiroyuki
43
Kiwada, Hiroshi
24
Futaki, Shiroh
21
Kogure, Kentaro
16
Akita, Hidetaka
11
Akita, Hidetaka
10
Kamiya, Hiroyuki
10
Ishida, Tatsuhiro
9
Kogure, Kentaro
8
Khalil, Ikramy
7
Akita, Hidetaka
7
Shinohara, Yasuo
6
Sugiyama, Yuichi
6
Tachibana, Rieko
6
Hanano, Manabu
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All Publications
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2009: Kamiya Hiroyuki; Hori Mika; Arimori Takao; Sekiguchi Mutsuo; Yamagata Yuriko; Harashima Hideyoshi
NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.
DNA repair 2009;8(10):1250-4.
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2009: Hatakeyama Hiroto; Ito Erika; Akita Hidetaka; Oishi Motoi; Nagasaki Yukio; Futaki Shiroh; Harashima Hideyoshi
A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.
Journal of controlled release : official journal of the Controlled Release Society 2009;139(2):127-32.
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2009: Masuda Tomoya; Akita Hidetaka; Niikura Kenichi; Nishio Takashi; Ukawa Masami; Enoto Kaoru; Danev Radostin; Nagayama Kuniaki; Ijiro Kuniharu; Harashima Hideyoshi
Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription.
Biomaterials 2009;30(27):4806-14.
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2009: El-Sayed Ayman; Masuda Tomoya; Khalil Ikramy; Akita Hidetaka; Harashima Hideyoshi
Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape.
Journal of controlled release : official journal of the Controlled Release Society 2009;138(2):160-7.
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2009: Kamiya Hiroyuki; Goto Hitomi; Harashima Hideyoshi
Effects of non-B DNA sequences on transgene expression.
Journal of bioscience and bioengineering 2009;108(1):20-3.
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2009: Kurihara Dai; Akita Hidetaka; Kudo Asako; Masuda Tomoya; Futaki Shiroh; Harashima Hideyoshi
Effect of polyethyleneglycol spacer on the binding properties of nuclear localization signal-modified liposomes to isolated nucleus.
Biological & pharmaceutical bulletin 2009;32(7):1303-6.
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2009: Takada Akitsugu; Kamiya Hiroyuki; Shuto Satoshi; Matsuda Akira; Harashima Hideyoshi
PK-PD modeling of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes.
International journal of pharmaceutics 2009;377(1-2):52-9.
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2009: Kamiya Hiroyuki; Fukunaga Satoki; Ohyama Takashi; Harashima Hideyoshi
Effects of carriers on transgene expression from plasmids containing a DNA sequence with high histone affinity.
International journal of pharmaceutics 2009;376(1-2):99-103.
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2009: Kamiya Hiroyuki; Suzuki Akihiro; Yamaguchi Yuki; Handa Hiroshi; Harashima Hideyoshi
Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases.
Free radical biology & medicine 2009;46(12):1703-7.
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2009: Higashi Tomoko; Khalil Ikramy A; Maiti Kaustabh K; Lee Woo Sirl; Akita Hidetaka; Harashima Hideyoshi; Chung Sung-Kee
Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2009;136(2):140-7.
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2009: Sakurai Yu; Hatakeyama Hiroto; Akita Hidetaka; Oishi Motoi; Nagasaki Yukio; Futaki Shiro; Harashima Hideyoshi
Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system.
Biological & pharmaceutical bulletin 2009;32(5):928-32.
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2009: Homhuan Atthachai; Kogure Kentaro; Nakamura Takashi; Shastri Nilabh; Harashima Hideyoshi
Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2009;136(1):79-85.
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2009: Akita Hidetaka; Kudo Asako; Minoura Arisa; Yamaguti Masaya; Khalil Ikramy A; Moriguchi Rumiko; Masuda Tomoya; Danev Radostin; Nagayama Kuniaki; Kogure Kentaro; Harashima Hideyoshi
Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.
Biomaterials 2009;30(15):2940-9.
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2009: Satou Kazuya; Hori Mika; Kawai Kazuaki; Kasai Hiroshi; Harashima Hideyoshi; Kamiya Hiroyuki
Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells.
DNA repair 2009;8(5):637-42.
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2009: Mudhakir Diky; Harashima Hideyoshi
Learning from the viral journey: how to enter cells and how to overcome intracellular barriers to reach the nucleus.
The AAPS journal 2009;11(1):65-77.
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2009: El-Sayed Ayman; Futaki Shiroh; Harashima Hideyoshi
Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment.
The AAPS journal 2009;11(1):13-22.
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2009: Joraku Akira; Homhuan Atthachai; Kawai Koji; Yamamoto Takahiro; Miyazaki Jun; Kogure Kentaro; Yano Ikuya; Harashima Hideyoshi; Akaza Hideyuki
Immunoprotection against murine bladder carcinoma by octaarginine-modified liposomes incorporating cell wall of Mycobacterium bovis bacillus Calmette-Guérin.
BJU international 2009;103(5):686-93.
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2009: Kamiya Hiroyuki; Satou Kazuya; Hori Mika; Yamaguchi Ayaka; Harashima Hideyoshi
Roles of specialized DNA polymerases in mutagenesis by oxidized guanine.
Nucleic acids symposium series (2004) 2009;(53):223-4.
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2008: Niikura Kenichi; Sekiguchi Shota; Nishio Takashi; Masuda Tomoya; Akita Hidetaka; Matsuo Yasutaka; Kogure Kentaro; Harashima Hideyoshi; Ijiro Kuniharu
Oligosaccharide-mediated nuclear transport of nanoparticles.
Chembiochem : a European journal of chemical biology 2008;9(16):2623-7.
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2008: Moriguchi Rumiko; Kogure Kentaro; Harashima Hideyoshi
Non-linear pharmacodynamics in the transfection efficiency of a non-viral gene delivery system.
International journal of pharmaceutics 2008;363(1-2):192-8.
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2008: Yamashita Atsushi; Kanda Daizo; Katoono Ryo; Yui Nobuhiko; Ooya Tooru; Maruyama Atsushi; Akita Hidetaka; Kogure Kentaro; Harashima Hideyoshi
Supramolecular control of polyplex dissociation and cell transfection: efficacy of amino groups and threading cyclodextrins in biocleavable polyrotaxanes.
Journal of controlled release : official journal of the Controlled Release Society 2008;131(2):137-44.
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2008: Yamada Yuma; Harashima Hideyoshi
Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases.
Advanced drug delivery reviews 2008;60(13-14):1439-62.
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2008: Kamiya Hiroyuki; Uchiyama Masayuki; Nakatsu Yoshimichi; Tsuzuki Teruhisa; Harashima Hideyoshi
Effects of target sequence and sense versus anti-sense strands on gene correction with single-stranded DNA fragments.
Journal of biochemistry 2008;144(4):431-6.
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2008: Akita Hidetaka; Harashima Hideyoshi
Advances in non-viral gene delivery: using multifunctional envelope-type nano-device.
Expert opinion on drug delivery 2008;5(8):847-59.
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2008: Tsuchiya Hiroyuki; Uchiyama Masayuki; Hara Kazuhiro; Nakatsu Yoshimichi; Tsuzuki Teruhisa; Inoue Hideo; Harashima Hideyoshi; Kamiya Hiroyuki
Improved gene correction efficiency with a tailed duplex DNA fragment.
Biochemistry 2008;47(33):8754-9.
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2008: Anas AbdulAziz; Akita Hidetaka; Harashima Hideyoshi; Itoh Tamitake; Ishikawa Mitsuru; Biju Vasudevanpillai
Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots.
The journal of physical chemistry. B 2008;112(32):10005-11.
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2008: Nakamura Takashi; Moriguchi Rumiko; Kogure Kentaro; Shastri Nilabh; Harashima Hideyoshi
Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(8):1507-14.
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2008: El-Sayed Ayman; Khalil Ikramy A; Kogure Kentaro; Futaki Shiroh; Harashima Hideyoshi
Octaarginine- and octalysine-modified nanoparticles have different modes of endosomal escape.
The Journal of biological chemistry 2008;283(34):23450-61.
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2008: Kuramoto Hiroshi; Park Yeon-Su; Kaji Noritada; Tokeshi Manabu; Kogure Kentaro; Shinohara Yasuo; Harashima Hideyoshi; Baba Yoshinobu
On-chip fabrication of mutifunctional envelope-type nanodevices for gene delivery.
Analytical and bioanalytical chemistry 2008;391(8):2729-33.
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2008: Sasaki Kentaro; Kogure Kentaro; Chaki Shinji; Nakamura Yoshio; Moriguchi Rumiko; Hamada Hirofumi; Danev Radostin; Nagayama Kuniaki; Futaki Shiroh; Harashima Hideyoshi
An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives.
Analytical and bioanalytical chemistry 2008;391(8):2717-27.
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2008: Suzuki Ryosuke; Yamada Yuma; Harashima Hideyoshi
Development of small, homogeneous pDNA particles condensed with mono-cationic detergents and encapsulated in a multifunctional envelope-type nano device.
Biological & pharmaceutical bulletin 2008;31(6):1237-43.
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2008: Khalil Ikramy A; Kogure Kentaro; Futaki Shiroh; Harashima Hideyoshi
Octaarginine-modified liposomes: enhanced cellular uptake and controlled intracellular trafficking.
International journal of pharmaceutics 2008;354(1-2):39-48.
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2008: Hidaka Katsuhiko; Yamada Masami; Kamiya Hiroyuki; Masutani Chikahide; Harashima Hideyoshi; Hanaoka Fumio; Nohmi Takehiko
Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta.
DNA repair 2008;7(3):497-506.
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2008: Kogure Kentaro; Akita Hidetaka; Yamada Yuma; Harashima Hideyoshi
Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system.
Advanced drug delivery reviews 2008;60(4-5):559-71.
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2008: Kogure Kentaro; Akita Hidetaka; Harashima Hideyoshi
[Development of various multifunctional envelope-type nano device MEND based on novel assembly technologies]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(2):219-32.
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2008: Yamada Yuma; Akita Hidetaka; Kamiya Hiroyuki; Kogure Kentaro; Yamamoto Takenori; Shinohara Yasuo; Yamashita Kikuji; Kobayashi Hideo; Kikuchi Hiroshi; Harashima Hideyoshi
MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion.
Biochimica et biophysica acta 2008;1778(2):423-32.
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2008: Masuda Tomoya; Akita Hidetaka; Nishio Takashi; Niikura Kenichi; Kogure Kentaro; Ijiro Kuniharu; Harashima Hideyoshi
Development of lipid particles targeted via sugar-lipid conjugates as novel nuclear gene delivery system.
Biomaterials 2008;29(6):709-23.
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2008: Mudhakir Diky; Akita Hidetaka; Tan Erdal; Harashima Hideyoshi
A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway.
Journal of controlled release : official journal of the Controlled Release Society 2008;125(2):164-73.
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2008: Suzuki Tetsuya; Yamamoto Kazuo; Harashima Hideyoshi; Kamiya Hiroyuki
Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP.
DNA repair 2008;7(1):88-94.
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2008: Harashima Hideyoshi
Multifunctional envelope type nano device for non-viral gene delivery: concept and application for nanomedicine.
Nucleic acids symposium series (2004) 2008;(52):87.
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2008: Akita Hidetaka; Harashima Hideyoshi
Nonviral gene delivery.
Contributions to nephrology 2008;159():13-29.
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2007: Hori Mika; Ishiguro Chieko; Suzuki Tetsuya; Nakagawa Noriko; Nunoshiba Tatsuo; Kuramitsu Seiki; Yamamoto Kazuo; Kasai Hiroshi; Harashima Hideyoshi; Kamiya Hiroyuki
UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides.
DNA repair 2007;6(12):1786-93.
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2007: Harashima Hideyoshi; Kogure Kentaro; Yamada Yuma; Akita Hidetaka; Kamiya Hiroyuki
[Development of multifunctional envelope type artificial viral-like gene delivery system]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(10):1655-72.
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2007: Hatakeyama Hiroto; Akita Hidetaka; Kogure Kentaro; Harashima Hideyoshi
[Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(10):1549-56.
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2007: Kogure Kentaro; Akita Hidetaka; Harashima Hideyoshi
Multifunctional envelope-type nano device for non-viral gene delivery: concept and application of Programmed Packaging.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):246-51.
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2007: Kamiya Hiroyuki; Suzuki Akihiro; Kawai Kazuaki; Kasai Hiroshi; Harashima Hideyoshi
Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription.
Free radical biology & medicine 2007;43(5):837-43.
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2007: Hatakeyama Hiroto; Akita Hidetaka; Ishida Emi; Hashimoto Koichi; Kobayashi Hideo; Aoki Takanori; Yasuda Junko; Obata Kenichi; Kikuchi Hiroshi; Ishida Tatsuhiro; Kiwada Hiroshi; Harashima Hideyoshi
Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.
International journal of pharmaceutics 2007;342(1-2):194-200.
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2007: Ochiai H; Fujimuro M; Yokosawa H; Harashima H; Kamiya H
Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression.
Gene therapy 2007;14(15):1152-9.
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2007: Homhuan Atthachai; Kogure Kentaro; Akaza Hideyuki; Futaki Shiroh; Naka Takashi; Fujita Yukiko; Yano Ikuya; Harashima Hideyoshi
New packaging method of mycobacterial cell wall using octaarginine-modified liposomes: enhanced uptake by and immunostimulatory activity of dendritic cells.
Journal of controlled release : official journal of the Controlled Release Society 2007;120(1-2):60-9.
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2007: Satou Kazuya; Kasai Hiroshi; Masutani Chikahide; Hanaoka Fumio; Harashima Hideyoshi; Kamiya Hiroyuki
2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract.
Biochemistry 2007;46(22):6639-46.
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2007: Nakamura Yoshio; Kogure Kentaro; Futaki Shiroh; Harashima Hideyoshi
Octaarginine-modified multifunctional envelope-type nano device for siRNA.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(3):360-7.
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2007: Atobe Kazutaka; Ishida Tatsuhiro; Ishida Emi; Hashimoto Kouichi; Kobayashi Hideo; Yasuda Jyunko; Aoki Takanori; Obata Ken-Ichi; Kikuchi Hiroshi; Akita Hidetaka; Asai Tomohiro; Harashima Hideyoshi; Oku Naoto; Kiwada Hiroshi
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).
Biological & pharmaceutical bulletin 2007;30(5):972-8.
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2007: Satou Kazuya; Kawai Kazuaki; Kasai Hiroshi; Harashima Hideyoshi; Kamiya Hiroyuki
Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells.
Free radical biology & medicine 2007;42(10):1552-60.
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2007: Shimizu Masatomi; Gruz Petr; Kamiya Hiroyuki; Masutani Chikahide; Xu Yan; Usui Yukio; Sugiyama Hiroshi; Harashima Hideyoshi; Hanaoka Fumio; Nohmi Takehiko
Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta.
Biochemistry 2007;46(18):5515-22.
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2007: Kamiya Hiroyuki; Fukunaga Satoki; Ohyama Takashi; Harashima Hideyoshi
The location of the left-handedly curved DNA sequence affects exogenous DNA expression in vivo.
Archives of biochemistry and biophysics 2007;461(1):7-12.
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2007: Kamiya Hiroyuki; Ito Mana; Harashima Hideyoshi
Induction of various mutations during PCRs with manganese and 8-hydroxy-dGTP.
Biological & pharmaceutical bulletin 2007;30(4):842-4.
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2007: Hayashi Yasuhiro; Iida Shinya; Sato Yuichiro; Nakaya Akihiro; Sawada Akihiro; Kaji Noritada; Kamiya Hiroyuki; Baba Yoshinobu; Harashima Hideyoshi
DNA microarray analysis of type 2 diabetes-related genes co-regulated between white blood cells and livers of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
Biological & pharmaceutical bulletin 2007;30(4):763-71.
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2007: Suzuki Ryosuke; Yamada Yuma; Harashima Hideyoshi
Efficient cytoplasmic protein delivery by means of a multifunctional envelope-type nano device.
Biological & pharmaceutical bulletin 2007;30(4):758-62.
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2007: Khalil I A; Kogure K; Futaki S; Hama S; Akita H; Ueno M; Kishida H; Kudoh M; Mishina Y; Kataoka K; Yamada M; Harashima H
Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery.
Gene therapy 2007;14(8):682-9.
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2007: Akita Hidetaka; Ito Rie; Kamiya Hiroyuki; Kogure Kentaro; Harashima Hideyoshi
Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression.
The journal of gene medicine 2007;9(3):197-207.
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2007: Niikura Kenichi; Nishio Takashi; Akita Hidetaka; Matsuo Yasutaka; Kamitani Ryosuke; Kogure Kentaro; Harashima Hideyoshi; Ijiro Kuniharu
Accumulation of O-GlcNAc-displaying CdTe quantum dots in cells in the presence of ATP.
Chembiochem : a European journal of chemical biology 2007;8(4):379-84.
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2007: Yamada Yuma; Akita Hidetaka; Kogure Kentaro; Kamiya Hiroyuki; Harashima Hideyoshi
Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria.
Mitochondrion 2007;7(1-2):63-71.
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2007: Kobayashi Tomotaka; Ishida Tatsuhiro; Okada Yurie; Ise Saori; Harashima Hideyoshi; Kiwada Hiroshi
Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.
International journal of pharmaceutics 2007;329(1-2):94-102.
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2007: Hatakeyama H; Akita H; Kogure K; Oishi M; Nagasaki Y; Kihira Y; Ueno M; Kobayashi H; Kikuchi H; Harashima H
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.
Gene therapy 2007;14(1):68-77.
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2007: Suzuki Tetsuya; Yamamoto Kazuo; Harashima Hideyoshi; Kamiya Hiroyuki
Base excision repair system suppresses mutagenesis caused by 8-hydroxy-dGTP in Escherichia coli.
Nucleic acids symposium series (2004) 2007;(51):51-2.
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2007: Hama Susumu; Akita Hidetaka; Iida Shinya; Mizuguchi Hiroyuki; Harashima Hideyoshi
Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.
Nucleic acids research 2007;35(5):1533-43.
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2006: Iida Shinya; Sato Yuichiro; Nakaya Akihiro; Shinohara Yasuo; Hayashi Yasuhiro; Sawada Akihiro; Nagata Hideya; Kaji Noritada; Kamiya Hiroyuki; Baba Yoshinobu; Harashima Hideyoshi
Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray.
Biological & pharmaceutical bulletin 2006;29(12):2451-9.
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2006: Kamiya Hiroyuki; Cadena-Amaro Claudio; Dugué Laurence; Yakushiji Hiroyuki; Minakawa Noriaki; Matsuda Akira; Pochet Sylvie; Nakabeppu Yusaku; Harashima Hideyoshi
Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein.
Journal of biochemistry 2006;140(6):843-9.
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2006: Akita Hidetaka; Hama Susumu; Mizuguchi Hiroyuki; Harashima Hideyoshi
[Development of non-viral vector based on the quantitative comparison of intracellular trafficking with viral vector]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2006;126(11):1047-57.
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2006: Yang Tianzhi; Hussain Alamdar; Bai Shuhua; Khalil Ikramy A; Harashima Hideyoshi; Ahsan Fakhrul
Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(3):289-97.
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2006: Fujiwara Takahiro; Akita Hidetaka; Furukawa Katsuko; Ushida Takashi; Mizuguchi Hiroyuki; Harashima Hideyoshi
Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus.
Biological & pharmaceutical bulletin 2006;29(7):1511-5.
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2006: Yamada Masami; Nunoshiba Tatsuo; Shimizu Masatomi; Gruz Petr; Kamiya Hiroyuki; Harashima Hideyoshi; Nohmi Takehiko
Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli.
Journal of bacteriology 2006;188(13):4992-5.
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2006: Iwasa Akitada; Akita Hidetaka; Khalil Ikramy; Kogure Kentaro; Futaki Shiroh; Harashima Hideyoshi
Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature.
Biochimica et biophysica acta 2006;1758(6):713-20.
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2006: Ochiai Hiroshi; Harashima Hideyoshi; Kamiya Hiroyuki
Silencing of exogenous DNA in cultured cells.
Biological & pharmaceutical bulletin 2006;29(6):1294-6.
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2006: Nakamura Takashi; Moriguchi Rumiko; Kogure Kentaro; Minoura Arisa; Masuda Tomoya; Akita Hidetaka; Kato Kazunori; Hamada Hirofumi; Ueno Masaharu; Futaki Shiroh; Harashima Hideyoshi
Delivery of condensed DNA by liposomal non-viral gene delivery system into nucleus of dendritic cells.
Biological & pharmaceutical bulletin 2006;29(6):1290-3.
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2006: Hori Mika; Asanuma Taketoshi; Inanami Osamu; Kuwabara Mikinori; Harashima Hideyoshi; Kamiya Hiroyuki
Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme.
Biological & pharmaceutical bulletin 2006;29(6):1087-91.
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2006: Kamiya H; Yamazaki J; Harashima H
Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells.
Gene therapy 2006;13(11):932.
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2006: Nakamura Yoshio; Kogure Kentaro; Yamada Yuma; Futaki Shiroh; Harashima Hideyoshi
Significant and prolonged antisense effect of a multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.
The Journal of pharmacy and pharmacology 2006;58(4):431-7.
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2006: Hama Susumu; Akita Hidetaka; Ito Rie; Mizuguchi Hiroyuki; Hayakawa Takao; Harashima Hideyoshi
Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(4):786-94.
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2006: Ooya Tooru; Choi Hak Soo; Yamashita Atsushi; Yui Nobuhiko; Sugaya Yuko; Kano Arihiro; Maruyama Atsushi; Akita Hidetaka; Ito Rie; Kogure Kentaro; Harashima Hideyoshi
Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery.
Journal of the American Chemical Society 2006;128(12):3852-3.
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2006: Khalil Ikramy A; Kogure Kentaro; Akita Hidetaka; Harashima Hideyoshi
Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery.
Pharmacological reviews 2006;58(1):32-45.
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2006: Kogure Kentaro; Akita Hidetaka; Harashima Hideyoshi
[Envelope-type nano device for gene delivery]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(2):258-62.
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2006: Ochiai Hiroshi; Harashima Hideyoshi; Kamiya Hiroyuki
Intranuclear disposition of exogenous DNA in vivo: silencing, methylation and fragmentation.
FEBS letters 2006;580(3):918-22.
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2006: Yamashita Atsushi; Choi Hak Soo; Ooya Tooru; Yui Nobuhiko; Akita Hidetaka; Kogure Kentaro; Harashima Hideyoshi
Improved cell viability of linear polyethylenimine through gamma-cyclodextrin inclusion for effective gene delivery.
Chembiochem : a European journal of chemical biology 2006;7(2):297-302.
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2006: Moriguchi Rumiko; Kogure Kentaro; Iwasa Akitada; Akita Hidetaka; Harashima Hideyoshi
Non-linear pharmacodynamics in a non-viral gene delivery system: positive non-linear relationship between dose and transfection efficiency.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(3):605-9.
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2006: Khalil Ikramy A; Kogure Kentaro; Futaki Shiroh; Harashima Hideyoshi
High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression.
The Journal of biological chemistry 2006;281(6):3544-51.
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2006: Akita Hidetaka; Tanimoto Mitsuhide; Masuda Tomoya; Kogure Kentaro; Hama Susumu; Ninomiya Keiko; Futaki Shiroh; Harashima Hideyoshi
Evaluation of the nuclear delivery and intra-nuclear transcription of plasmid DNA condensed with micro (mu) and NLS-micro by cytoplasmic and nuclear microinjection: a comparative study with poly-L-lysine.
The journal of gene medicine 2006;8(2):198-206.
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2006: Ji Bin; Maeda Jun; Higuchi Makoto; Inoue Kaori; Akita Hidetaka; Harashima Hideyoshi; Suhara Tetsuya
Pharmacokinetics and brain uptake of lactoferrin in rats.
Life sciences 2006;78(8):851-5.
-
2006: Yamashita Atsushi; Yui Nobuhiko; Ooya Tooru; Kano Arihiro; Maruyama Atsushi; Akita Hidetaka; Kogure Kentaro; Harashima Hideyoshi
Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei.
Nature protocols 2006;1(6):2861-9.
-
2006: Kamiya Hiroyuki; Suzuki Akihiro; Kawai Kazuaki; Kasai Hiroshi; Harashima Hideyoshi
Mutagenic properties of oxidized GTP and ATP in in vitro transcription-reverse transcription.
Nucleic acids symposium series (2004) 2006;(50):99-100.
-
2006: Kamiya Hiroyuki; Ochiai Hiroshi; Harashima Hideyoshi; Ito Mana; Matsuda Akira
Transient expression of Drosophila melanogaster deoxynucleoside kinase gene enhances cytotoxicity of nucleoside analogs.
Nucleosides, nucleotides & nucleic acids 2006;25(4-6):553-60.
-
2006: Abe Hideki; Fujihara Mitsuhiro; Azuma Hiroshi; Ikeda Hisami; Ikebuchi Kenji; Takeoka Shinji; Tsuchida Eishun; Harashima Hideyoshi
Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier, with human plasma: effects on coagulation, kallikrein-kinin, and complement systems.
Artificial cells, blood substitutes, and immobilization biotechnology 2006;34(1):1-10.
-
2005: Choi Hak Soo; Yamashita Atsushi; Ooya Tooru; Yui Nobuhiko; Akita Hidetaka; Kogure Kentaro; Ito Rie; Harashima Hideyoshi
Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device.
Chembiochem : a European journal of chemical biology 2005;6(11):1986-90.
-
2005: Tsuchiya Hiroyuki; Harashima Hideyoshi; Kamiya Hiroyuki
Factors affecting SFHR gene correction efficiency with single-stranded DNA fragment.
Biochemical and biophysical research communications 2005;336(4):1194-200.
-
2005: Futaki Shiroh; Masui Yumi; Nakase Ikuhiko; Sugiura Yukio; Nakamura Takashi; Kogure Kentaro; Harashima Hideyoshi
Unique features of a pH-sensitive fusogenic peptide that improves the transfection efficiency of cationic liposomes.
The journal of gene medicine 2005;7(11):1450-8.
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2005: Ochiai Hiroshi; Harashima Hideyoshi; Kamiya Hiroyuki
Effect of methylated adenine in plasmid DNA on transgene expression in mice.
Biological & pharmaceutical bulletin 2005;28(10):2019-22.
-
2005: Tsuchiya Hiroyuki; Sawamura Tomoko; Harashima Hideyoshi; Kamiya Hiroyuki
Correction of frameshift mutations with single-stranded and double-stranded DNA fragments prepared from phagemid/plasmid DNAs.
Biological & pharmaceutical bulletin 2005;28(10):1958-62.
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2005: Yamada Yuma; Kogure Kentaro; Nakamura Yoshio; Inoue Kaori; Akita Hidetaka; Nagatsugi Fumi; Sasaki Shigeki; Suhara Tetsuya; Harashima Hideyoshi
Development of efficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure.
Biological & pharmaceutical bulletin 2005;28(10):1939-42.
-
2005: Yamada Yuma; Shinohara Yasuo; Kakudo Tomoyuki; Chaki Shinji; Futaki Shiroh; Kamiya Hiroyuki; Harashima Hideyoshi
Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.
International journal of pharmaceutics 2005;303(1-2):1-7.
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2005: Moriguchi Rumiko; Kogure Kentaro; Akita Hidetaka; Futaki Shiroh; Miyagishi Makoto; Taira Kazunari; Harashima Hideyoshi
A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.
International journal of pharmaceutics 2005;301(1-2):277-85.
-
2005: Mudhakir Diky; Akita Hidetaka; Khalil Ikramy A; Futaki Shiroh; Harashima Hideyoshi
Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice.
Drug metabolism and pharmacokinetics 2005;20(4):275-81.
-
2005: Satou Kazuya; Yamada Masami; Nohmi Takehiko; Harashima Hideyoshi; Kamiya Hiroyuki
Mutagenesis induced by oxidized DNA precursors: roles of Y family DNA polymerases in Escherichia coli.
Chemical research in toxicology 2005;18(8):1271-8.
-
2005: Yamada Yuma; Kamiya Hiroyuki; Harashima Hideyoshi
Kinetic analysis of protein production after DNA transfection.
International journal of pharmaceutics 2005;299(1-2):34-40.
-
2005: Hoshika Shuichi; Minakawa Noriaki; Kamiya Hiroyuki; Harashima Hideyoshi; Matsuda Akira
RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells.
FEBS letters 2005;579(14):3115-8.
-
2005: Sasaki Kentaro; Kogure Kentaro; Chaki Sinji; Kihira Yoshitaka; Ueno Masaharu; Harashima Hideyoshi
Construction of a multifunctional envelope-type nano device by a SUV*-fusion method.
International journal of pharmaceutics 2005;296(1-2):142-50.
-
2005: Iida Emiko; Satou Kazuya; Mishima Masaki; Kojima Chojiro; Harashima Hideyoshi; Kamiya Hiroyuki
Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein.
Biochemistry 2005;44(15):5683-9.
-
2005: Masuda Tomoya; Akita Hidetaka; Harashima Hideyoshi
Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: the use of a nuclear transfer score.
FEBS letters 2005;579(10):2143-8.
-
2005: Tsuchiya Hiroyuki; Harashima Hideyoshi; Kamiya Hiroyuki
Increased SFHR gene correction efficiency with sense single-stranded DNA.
The journal of gene medicine 2005;7(4):486-93.
-
2005: Hori Mika; Ishiguro Chieko; Harashima Hideyoshi; Kamiya Hiroyuki
In vivo mutagenicities of damaged nucleotides produced by nitric oxide and ionizing radiation.
Biological & pharmaceutical bulletin 2005;28(3):520-2.
-
2005: Tsuchiya Hiroyuki; Matsuda Tadashi; Harashima Hideyoshi; Kamiya Hiroyuki
Cytokine induction by a bacterial DNA-specific modified base.
Biochemical and biophysical research communications 2005;326(4):777-81.
-
2005: Hori Mika; Fujikawa Katsuyoshi; Kasai Hiroshi; Harashima Hideyoshi; Kamiya Hiroyuki
Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme.
DNA repair 2005;4(1):33-9.
-
2005: Tsuchiya Hiroyuki; Sawamura Tomoko; Uchiyama Masayuki; Harashima Hideyoshi; Kamiya Hiroyuki
Conversion of nucleotide sequence with single-stranded DNA fragment prepared from phagemid DNA.
Nucleic acids symposium series (2004) 2005;(49):93-4.
-
2005: Kato Yuka; Minakawa Noriaki; Komatsu Yasuo; Kamiya Hiroyuki; Ogawa Naoki; Harashima Hideyoshi; Matsuda Akira
New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX.
Nucleic acids research 2005;33(9):2942-51.
-
2004: Kamiya Hiroyuki; Iida Emiko; Harashima Hideyoshi
Important amino acids in the phosphohydrolase module of Escherichia coli Orf135.
Biochemical and biophysical research communications 2004;323(3):1063-8.
-
2004: Kamiya Hiroyuki; Ishiguro Chieko; Harashima Hideyoshi
Increased A:T-->C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: direct evidence for MutT involvement in the prevention of mutations by oxidized dGTP.
Journal of biochemistry 2004;136(3):359-62.
-
2004: Hatakeyama Hiroto; Akita Hidetaka; Maruyama Kazuo; Suhara Tetsuya; Harashima Hideyoshi
Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo.
International journal of pharmaceutics 2004;281(1-2):25-33.
-
2004: Kogure Kentaro; Moriguchi Rumiko; Sasaki Kentaro; Ueno Masaharu; Futaki Shiroh; Harashima Hideyoshi
Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method.
Journal of controlled release : official journal of the Controlled Release Society 2004;98(2):317-23.
-
2004: Tsuchiya Hiroyuki; Kuwata Keizou; Nagayama Sekio; Yamashita Kazumasa; Kamiya Hiroyuki; Harashima Hideyoshi
Pharmacokinetic modeling of species-dependent enhanced bioavailability of trifluorothymidine by thymidine phosphorylase inhibitor.
Drug metabolism and pharmacokinetics 2004;19(3):206-15.
-
2004: Fisher David I; Cartwright Jared L; Harashima Hideyoshi; Kamiya Hiroyuki; McLennan Alexander G
Characterization of a nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates.
BMC biochemistry 2004;5():7.
-
2004: Kakudo Tomoyuki; Chaki Shinji; Futaki Shiroh; Nakase Ikuhiko; Akaji Kenichi; Kawakami Toru; Maruyama Kazuo; Kamiya Hiroyuki; Harashima Hideyoshi
Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system.
Biochemistry 2004;43(19):5618-28.
-
2004: Kamiya Hiroyuki; Ito Mana; Harashima Hideyoshi
Induction of transition and transversion mutations during random mutagenesis PCR by the addition of 2-hydroxy-dATP.
Biological & pharmaceutical bulletin 2004;27(5):621-3.
-
2004: Khalil I A; Futaki S; Niwa M; Baba Y; Kaji N; Kamiya H; Harashima H
Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation.
Gene therapy 2004;11(7):636-44.
-
2004: Kamiya Hiroyuki; Yakushiji Hiroyuki; Dugué Laurence; Tanimoto Mitsuhide; Pochet Sylvie; Nakabeppu Yusaku; Harashima Hideyoshi
Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs.
Journal of molecular biology 2004;336(4):843-50.
-
2004: Tachibana Rieko; Ide Naoko; Shinohara Yasuo; Harashima Hideyoshi; Hunt C Anthony; Kiwada Hiroshi
An assessment of relative transcriptional availability from nonviral vectors.
International journal of pharmaceutics 2004;270(1-2):315-21.
-
2004: Kamiya Hiroyuki; Satou Kazuya; Hori Mika; Iida Emiko; Ishiguro Chieko; Harashima Hideyoshi
Mutagenesis by damaged deoxyribonucleotides and its prevention by MutT-type hydrolyzing enzymes.
Nucleic acids symposium series (2004) 2004;(48):271-2.
-
2003: Kamiya Hiroyuki; Iida Emiko; Murata-Kamiya Naoko; Yamamoto Yoshihiro; Miki Takeyoshi; Harashima Hideyoshi
Suppression of spontaneous and hydrogen peroxide-induced mutations by a MutT-type nucleotide pool sanitization enzyme, the Escherichia coli Orf135 protein.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(12):941-50.
-
2003: Sato Yuichiro; Kuwajima Masamichi; Kamiya Hiroyuki; Harashima Hideyoshi
Calpain 10 as a predictive gene for type 2 diabetes: evidence from a novel screening system using white blood cells of Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
Biological & pharmaceutical bulletin 2003;26(12):1765-8.
-
2003: Kamiya Hiroyuki; Akita Hidetaka; Harashima Hideyoshi
Pharmacokinetic and pharmacodynamic considerations in gene therapy.
Drug discovery today 2003;8(21):990-6.
-
2003: Tanimoto Mitsuhide; Kamiya Hiroyuki; Minakawa Noriaki; Matsuda Akira; Harashima Hideyoshi
No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA.
Bioconjugate chemistry 2003;14(6):1197-202.
-
2003: Satou Kazuya; Harashima Hideyoshi; Kamiya Hiroyuki
Mutagenic effects of 2-hydroxy-dATP on replication in a HeLa extract: induction of substitution and deletion mutations.
Nucleic acids research 2003;31(10):2570-5.
-
2003: Shimizu Masatomi; Gruz Petr; Kamiya Hiroyuki; Kim Su-Ryang; Pisani Francesca M; Masutani Chikahide; Kanke Yusuke; Harashima Hideyoshi; Hanaoka Fumio; Nohmi Takehiko
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases.
EMBO reports 2003;4(3):269-73.
-
2003: Almofti Mohamad Radwan; Harashima Hideyoshi; Shinohara Yasuo; Almofti Ammar; Baba Yoshinobu; Kiwada Hiroshi
Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization.
Archives of biochemistry and biophysics 2003;410(2):246-53.
-
2003: Almofti Mohamad Radwan; Harashima Hideyoshi; Shinohara Yasuo; Almofti Ammar; Li Wenhao; Kiwada Hiroshi
Lipoplex size determines lipofection efficiency with or without serum.
Molecular membrane biology 2003;20(1):35-43.
-
2003: Tachibana Rieko; Futaki Shiroh; Harashima Hideyoshi; Kiwada Hiroshi
pH-sensitive liposomes in nuclear targeting of macromolecules.
Methods in enzymology 2003;372():349-61.
-
2003: Satou Kazuya; Harashima Hideyoshi; Kamiya Hiroyuki
Mutations induced by 2-hydroxy-dATP during in vitro replication with a HeLa extract.
Nucleic acids research. Supplement (2001) 2003;(3):325-6.
-
2003: Nishimoto Naomi; Kamiya Hiroyuki; Harashima Hideyoshi; Izuta Shunji
Utilization efficiency of the oxidized purine nucleotide analogs by DNA polymerase eta.
Nucleic acids research. Supplement (2001) 2003;(3):299-300.
-
2002: Kamiya Hiroyuki; Fujimura Yuka; Matsuoka Ichiro; Harashima Hideyoshi
Visualization of intracellular trafficking of exogenous DNA delivered by cationic liposomes.
Biochemical and biophysical research communications 2002;298(4):591-7.
-
2002: Kamiya H; Yamazaki J; Harashima H
Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells.
Gene therapy 2002;9(22):1500-7.
-
2002: Kamiya Hiroyuki; Tsuchiya Hiroyuki; Karino Naoko; Ueno Yoshihito; Matsuda Akira; Harashima Hideyoshi
Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells.
Journal of biochemistry 2002;132(4):551-5.
-
2002: Ishida Tatsuhiro; Harashima Hideyoshi; Kiwada Hiroshi
Liposome clearance.
Bioscience reports 2002;22(2):197-224.
-
2002: Tachibana Rieko; Harashima Hideyoshi; Ide Naoko; Ukitsu Sachiko; Ohta Yasuko; Suzuki Norio; Kikuchi Hiroshi; Shinohara Yasuo; Kiwada Hiroshi
Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes.
Pharmaceutical research 2002;19(4):377-81.
-
2002: Tachibana Rieko; Harashima Hideyoshi; Ishida Tatsuhiro; Shinohara Yasuo; Hino Mami; Terada Hiroshi; Baba Yoshinobu; Kiwada Hiroshi
Effect of cationic liposomes in an in vitro transcription and translation system.
Biological & pharmaceutical bulletin 2002;25(4):529-31.
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2002: Abe Akihito; Kiriyama Yoshimitsu; Hirano Masako; Miura Toshiaki; Kamiya Hiroyuki; Harashima Hideyoshi; Tokumitsu Yukiko
Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma.
European journal of pharmacology 2002;436(1-2):7-13.
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2002: Kamiya Hiroyuki; Dugué Laurence; Yakushiji Hiroyuki; Pochet Sylvie; Nakabeppu Yusaku; Harashima Hideyoshi
Substrate recognition by the human MTH1 protein.
Nucleic acids research. Supplement (2001) 2002;(2):85-6.
-
2002: Harashima Hideyoshi; Ishida Tatsuhiro; Kamiya Hiroyuki; Kiwada Hiroshi
Pharmacokinetics of targeting with liposomes.
Critical reviews in therapeutic drug carrier systems 2002;19(3):235-75.
-
2001: Ishida T; Harashima H; Kiwada H
Interactions of liposomes with cells in vitro and in vivo: opsonins and receptors.
Current drug metabolism 2001;2(4):397-409.
-
2001: Tachibana R; Harashima H; Shinohara Y; Kiwada H
Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors.
Advanced drug delivery reviews 2001;52(3):219-26.
-
2001: Kamiya H; Tsuchiya H; Yamazaki J; Harashima H
Intracellular trafficking and transgene expression of viral and non-viral gene vectors.
Advanced drug delivery reviews 2001;52(3):153-64.
-
2001: Futaki S; Ohashi W; Suzuki T; Niwa M; Tanaka S; Ueda K; Harashima H; Sugiura Y
Stearylated arginine-rich peptides: a new class of transfection systems.
Bioconjugate chemistry 2001;12(6):1005-11.
-
2001: Kamiya H; Murata-Kamiya N; Iida E; Harashima H
Hydrolysis of oxidized nucleotides by the Escherichia coli Orf135 protein.
Biochemical and biophysical research communications 2001;288(3):499-502.
-
2001: Ishida T; Yasukawa K; Kojima H; Harashima H; Kiwada H
Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidylcholine-based liposomes.
International journal of pharmaceutics 2001;224(1-2):69-79.
-
2001: Huong T M; Ishida T; Harashima H; Kiwada H
Species difference in correlation between in vivo/in vitro liposome-complement interactions.
Biological & pharmaceutical bulletin 2001;24(4):439-41.
-
2001: Harashima H; Shinohara Y; Kiwada H
Intracellular control of gene trafficking using liposomes as drug carriers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(1):85-9.
-
2001: Huong T M; Ishida T; Harashima H; Kiwada H
The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig.
International journal of pharmaceutics 2001;215(1-2):197-205.
-
2000: Ishida T; Kojima H; Harashima H; Kiwada H
Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their relationship.
International journal of pharmaceutics 2000;205(1-2):183-93.
-
1999: Harashima H; Iida S; Urakami Y; Tsuchihashi M; Kiwada H
Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):93-106.
-
1999: Tsuchihashi M; Harashima H; Kiwada H
Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):9-19.
-
1999: Huong T M; Harashima H; Kiwada H
In vivo studies on the role of complement in the clearance of liposomes in rats and guinea pigs.
Biological & pharmaceutical bulletin 1999;22(5):515-20.
-
1999: Kuwajima M; Harashima H; Hayashi M; Ise S; Sei M; Lu K m; Kiwada H; Sugiyama Y; Shima K
Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney.
The Journal of pharmacology and experimental therapeutics 1999;289(1):93-102.
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1999: Kuwajima M; Horiuchi M; Harashima H; Lu K; Hayashi M; Sei M; Ozaki K; Kudo T; Kamido H; Ono A; Saheki T; Shima K
Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection.
FEBS letters 1999;443(3):261-6.
-
1998: Komori T; Shimoishi K; Harashima H; Otagiri M
Effects of repeated clarithromycin administration on the pharmacokinetic properties of pindolol in rats.
Biological & pharmaceutical bulletin 1998;21(12):1376-8.
-
1998: Tachibana R; Harashima H; Shono M; Azumano M; Niwa M; Futaki S; Kiwada H
Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: qualitative and quantitative evaluation of intracellular trafficking.
Biochemical and biophysical research communications 1998;251(2):538-44.
-
1998: Huong T M; Harashima H; Kiwada H
Complement dependent and independent liposome uptake by peritoneal macrophages: cholesterol content dependency.
Biological & pharmaceutical bulletin 1998;21(9):969-73.
-
1998: Yamada M; Harashima H; Kiwada H
Kinetic analysis of the interaction between liposomes and the complement system in rat serum: re-evaluation of size-dependency.
Biological & pharmaceutical bulletin 1998;21(9):964-8.
-
1996: Harashima H; Huong T M; Ishida T; Manabe Y; Matsuo H; Kiwada H
Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats.
Pharmaceutical research 1996;13(11):1704-9.
-
1996: Yachi K; Harashima H; Kikuchi H; Sudo R; Yamauchi H; Ebihara K; Matsuo H; Funato K; Kiwada H
Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug.
Biopharmaceutics & drug disposition 1996;17(7):589-605.
-
1996: Harashima H; Komatsu S; Kojima S; Yanagi C; Morioka Y; Naito M; Kiwada H
Species difference in the disposition of liposomes among mice, rats, and rabbits: allometric relationship and species dependent hepatic uptake mechanism.
Pharmaceutical research 1996;13(7):1049-54.
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1996: Kuwajima M; Lu K; Harashima H; Ono A; Sato I; Mizuno A; Murakami T; Nakajima H; Miyagawa J; Namba M; Hanafusa T; Hayakawa J; Matsuzawa Y; Shima K
Carnitine transport defect in fibroblasts of juvenile visceral steatosis (JVS) mouse.
Biochemical and biophysical research communications 1996;223(2):283-7.
-
1996: Ferdous A J; Ishida T; Shinohara M; Harashima H; Kiwada H
Size-dependent release of carboxyfluorescein from cetylmannoside-modified liposomes in human plasma.
Biopharmaceutics & drug disposition 1996;17(2):145-54.
-
1996: Wada D R; Harashima H; Ebling W; Osaki E W; Stanski D R
Effects of thiopental on regional blood flows in the rat.
Anesthesiology 1996;84(3):596-604.
-
1995: Harashima H; Hirai N; Kiwada H
Kinetic modelling of liposome degradation in peritoneal macrophages.
Biopharmaceutics & drug disposition 1995;16(2):113-23.
-
1995: Harashima H; Hiraiwa T; Ochi Y; Kiwada H
Size dependent liposome degradation in blood: in vivo/in vitro correlation by kinetic modeling.
Journal of drug targeting 1995;3(4):253-61.
-
1994: Harashima H; Kiwada H; Kajita J; Kobayashi S
Effects of benidipine hydrochloride (Coniel), a new calcium antagonist, on the cardiac output, regional blood flow and vascular resistance in conscious, spontaneously hypertensive rats.
Biopharmaceutics & drug disposition 1994;15(5):431-8.
-
1994: Harashima H; Ochi Y; Kiwada H
Kinetic modelling of liposome degradation in serum: effect of size and concentration of liposomes in vitro.
Biopharmaceutics & drug disposition 1994;15(3):217-25.
-
1994: Harashima H; Sakata K; Funato K; Kiwada H
Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes.
Pharmaceutical research 1994;11(3):402-6.
-
1994: Matsuo H; Funato K; Harashima H; Kiwada H
The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ.
Journal of drug targeting 1994;2(2):141-6.
-
1993: Harashima H; Midori Y; Ohshima S; Yachi K; Kikuchi H; Kiwada H
Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II).
Biopharmaceutics & drug disposition 1993;14(7):595-608.
-
1993: Harashima H; Yamane C; Kume Y; Kiwada H
Kinetic analysis of AUC-dependent saturable clearance of liposomes: mathematical description of AUC dependency.
Journal of pharmacokinetics and biopharmaceutics 1993;21(3):299-308.
-
1993: Björkman S; Stanski D R; Harashima H; Dowrie R; Harapat S R; Wada D R; Ebling W F
Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model.
Journal of pharmacokinetics and biopharmaceutics 1993;21(3):255-79.
-
1993: Harashima H; Kume Y; Yamane C; Kiwada H
Kinetic modeling of liposome degradation in blood circulation.
Biopharmaceutics & drug disposition 1993;14(3):265-70.
-
1993: Harashima H; Sakata K; Kiwada H
Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake of liposomes.
Pharmaceutical research 1993;10(4):606-10.
-
1992: Harashima H; Mamiya M; Yamazaki M; Sawada Y; Iga T; Hanano M; Sugiyama Y
Kinetic modeling of ouabain tissue distribution based on slow and saturable binding to Na,K-ATPase.
Pharmaceutical research 1992;9(12):1607-11.
-
1992: Harashima H; Ohnishi Y; Kiwada H
In vivo evaluation of the effect of the size and opsonization on the hepatic extraction of liposomes in rats: an application of Oldendorf method.
Biopharmaceutics & drug disposition 1992;13(7):549-53.
-
1992: Harashima H; Kume Y; Yamane C; Kiwada H
Non-Michaelis-Menten type hepatic uptake of liposomes in the rat.
The Journal of pharmacy and pharmacology 1992;44(9):707-12.
-
1992: Harashima H; Ohshima S; Midori Y; Yachi K; Kikuchi H; Kiwada H
Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats: I.
Biopharmaceutics & drug disposition 1992;13(3):155-70.
-
1992: Harashima H; Mamiya M; Yamazaki M; Sugiyama Y; Sawada Y; Iga T; Hanano M
Significance of binding to Na,K-ATPase in the tissue distribution of ouabain in guinea pigs.
Pharmaceutical research 1992;9(4):474-9.
-
1991: Kume Y; Maeda F; Harashima H; Kiwada H
Saturable, non-Michaelis-Menten uptake of liposomes by the reticuloendothelial system.
The Journal of pharmacy and pharmacology 1991;43(3):162-6.
-
1990: Chung Y B; Miyauchi S; Sugiyama Y; Harashima H; Iga T; Hanano M
Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate.
Journal of hepatology 1990;11(2):240-51.
-
1990: Chung Y B; Miyauchi S; Sugiyama Y; Harashima H; Iga T; Hanano M
Kinetic analysis of the dose-dependent hepatic handling of 1-anilino-8-naphthalene sulfonate in rats.
Journal of pharmacokinetics and biopharmaceutics 1990;18(4):313-33.
-
1990: Björkman S; Stanski D R; Verotta D; Harashima H
Comparative tissue concentration profiles of fentanyl and alfentanil in humans predicted from tissue/blood partition data obtained in rats.
Anesthesiology 1990;72(5):865-73.
-
1988: Harashima H; Sugiyama Y; Sawada Y; Shigenobu K; Kasuya Y; Iga T; Hanano M
Kinetic analysis of the positive inotropic action (PIA) of ouabain in isolated perfused rabbit heart. Slow onset of PIA and slow binding to Na+, K+-adenosine triphosphatase.
Journal of pharmacobio-dynamics 1988;11(8):533-40.
-
1988: Harashima H; Sugiyama Y; Iga T; Hanano M
Nonlinear tissue distribution of ouabain in rabbits.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(4):645-9.
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