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Doreen Harcus

Research Profile

Living Beings

Chemicals & Drugs

Physiology

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Genes & Molecular Sequences

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Candidiasis

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Publications

TOP 3
Volodymyr Yerko; Jason Baardsnes; Miroslaw Cygler; Irena Ekiel; Doreen Harcus; Traian Sulea; Malcolm Whiteway; Cunle Wu
Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling.
Elias Epp; Ghyslaine Vanier; Doreen Harcus; Anna Y Lee; Gregor Jansen; Michael Hallett; Don C Sheppard; David Y Thomas; Carol A Munro; Alaka Mullick; Malcolm Whiteway
Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.
Irena Ekiel; Traian Sulea; Gregor Jansen; Maria Kowalik; Ovidiu Minailiuc; Jing Cheng; Doreen Harcus; Miroslaw Cygler; Malcolm Whiteway; Cunle Wu
Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.

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All Publications

2013: Volodymyr Yerko; Jason Baardsnes; Miroslaw Cygler; Irena Ekiel; Doreen Harcus; Traian Sulea; Malcolm Whiteway; Cunle Wu
Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling.
Molecular biology of the cell 2013;24(3):409-20.
2010: Elias Epp; Ghyslaine Vanier; Doreen Harcus; Anna Y Lee; Gregor Jansen; Michael Hallett; Don C Sheppard; David Y Thomas; Carol A Munro; Alaka Mullick; Malcolm Whiteway
Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.
PLoS pathogens 2010;6(2):e1000753.
2009: Irena Ekiel; Traian Sulea; Gregor Jansen; Maria Kowalik; Ovidiu Minailiuc; Jing Cheng; Doreen Harcus; Miroslaw Cygler; Malcolm Whiteway; Cunle Wu
Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.
Molecular biology of the cell 2009;20(24):5117-26.
2009: Gregor Jansen; Anna Y Lee; Elias Epp; Amélie Fredette; Jamie Surprenant; Doreen Harcus; Michelle Scott; Elaine Tan; Tamiko Nishimura; Malcolm Whiteway; Michael Hallett; David Y Thomas
Chemogenomic profiling predicts antifungal synergies.
Molecular systems biology 2009;5():338.
2008: Hao Huang; Doreen Harcus; Malcolm Whiteway
Transcript profiling of a MAP kinase pathway in C. albicans.
Microbiological research 2008;163(4):380-93.
2004: Doreen Harcus; André Nantel; Anne Marcil; Tracey Rigby; Malcolm Whiteway
Transcription profiling of cyclic AMP signaling in Candida albicans.
Molecular biology of the cell 2004;15(10):4490-9.
2004: Mikhail Martchenko; Anne-Marie Alarco; Doreen Harcus; Malcolm Whiteway
Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene.
Molecular biology of the cell 2004;15(2):456-67.
2002: Anne Marcil; Doreen Harcus; David Y Thomas; Malcolm Whiteway
Candida albicans killing by RAW 264.7 mouse macrophage cells: effects of Candida genotype, infection ratios, and gamma interferon treatment.
Infection and immunity 2002;70(11):6319-29.
2002: André Nantel; Daniel Dignard; Catherine Bachewich; Doreen Harcus; Anne Marcil; Anne-Pascale Bouin; Christoph Wilhelm Sensen; Hervé Hogues; Marco van het Hoog; Paul Gordon; Tracey Rigby; François Benoit; Daniel C Tessier; David Y Thomas; Malcolm Whiteway
Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition.
Molecular biology of the cell 2002;13(10):3452-65.
2002: Sophia C Ushinsky; Doreen Harcus; Josee Ash; Daniel Dignard; Anne Marcil; Joachim Morchhauser; David Y Thomas; Malcolm Whiteway; Ekkehard Leberer
CDC42 is required for polarized growth in human pathogen Candida albicans.
Eukaryotic cell 2002;1(1):95-104.
2001: Ekkehard Leberer; Doreen Harcus; Daniel Dignard; L Johnson; Sophia C Ushinsky; David Y Thomas; Klaus Schröppel
Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans.
Molecular microbiology 2001;42(3):673-87.
2001: C R Rocha; Klaus Schröppel; Doreen Harcus; Anne Marcil; Daniel Dignard; Brad N Taylor; David Y Thomas; Malcolm Whiteway; Ekkehard Leberer
Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans.
Molecular biology of the cell 2001;12(11):3631-43.
1998: Faisal Guhad; Henrik Elvang Jensen; Bent Aalbaek; C Csank; O Mohamed; Doreen Harcus; D Y Thomas; Malcolm Whiteway; Jann Hau
Mitogen-activated protein kinase-defective Candida albicans is avirulent in a novel model of localized murine candidiasis.
FEMS microbiology letters 1998;166(1):135-9.
1998: C Csank; Klaus Schröppel; Ekkehard Leberer; Doreen Harcus; O Mohamed; Sylvain Meloche; David Y Thomas; Malcolm Whiteway
Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis.
Infection and immunity 1998;66(6):2713-21.
1997: Ekkehard Leberer; K Ziegelbauer; A Schmidt; Doreen Harcus; Daniel Dignard; Josee Ash; L Johnson; David Y Thomas
Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p.
Current biology : CB 1997;7(8):539-46.
1996: Ekkehard Leberer; Doreen Harcus; I D Broadbent; K L Clark; Daniel Dignard; K Ziegelbauer; A Schmidt; Neil A R Gow; A J Brown; David Y Thomas
Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13217-22.
1996: Ekkehard Leberer; J Chenevert; T Leeuw; Doreen Harcus; I Herskowitz; David Y Thomas
Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity.
Molecular & general genetics : MGG 1996;252(5):608-21.
1994: Ekkehard Leberer; Daniel Dignard; Doreen Harcus; Malcolm Whiteway; David Y Thomas
Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction.
The EMBO journal 1994;13(13):3050-64.
1993: Ekkehard Leberer; Daniel Dignard; Doreen Harcus; L Hougan; Malcolm Whiteway; David Y Thomas
Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Far1.
Molecular & general genetics : MGG 1993;241(3-4):241-54.
1992: Ekkehard Leberer; Daniel Dignard; Doreen Harcus; David Y Thomas; Malcolm Whiteway
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.
The EMBO journal 1992;11(13):4815-24.