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Edna Hardeman

Research Profile

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Disorders

Nemaline Myopathies

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Publications

TOP 3
Justin G Lees; Michael S Samuel; Damian H Adams; Cuc T T Bach; Yu Wooi Ching; Allison J Cowin; Peter Gunning; Edna C Hardeman; Anthony J Kee; Geraldine M O'Neill
Tropomyosin Regulates Cell Migration during Skin Wound Healing.
Charlotte Gineste; David Bendahan; Patrick J Cozzone; Edna C Hardeman; Yann Le Fur; Arnaud Le Troter; Emilie Pecchi; Christophe Vilmen; JULIEN GONDIN
Combined MRI and (31)P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy Metabolism.
Stephen J Palmer; Nicole Santucci; Kylie M Taylor; Jocelyn Widagdo; Jen-Li Yeo; Merritt Adams; Yee-Ka Agnes Chan; Peter W Gunning; Edna C Hardeman
GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

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All Publications

2013: Justin G Lees; Michael S Samuel; Damian H Adams; Cuc T T Bach; Yu Wooi Ching; Allison J Cowin; Peter Gunning; Edna C Hardeman; Anthony J Kee; Geraldine M O'Neill
Tropomyosin Regulates Cell Migration during Skin Wound Healing.
The Journal of investigative dermatology 2013;133(5):1330-9.
2013: Charlotte Gineste; David Bendahan; Patrick J Cozzone; Edna C Hardeman; Yann Le Fur; Arnaud Le Troter; Emilie Pecchi; Christophe Vilmen; JULIEN GONDIN
Combined MRI and (31)P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy Metabolism.
PloS one 2013;8(4):e61517.
2012: Stephen J Palmer; Nicole Santucci; Kylie M Taylor; Jocelyn Widagdo; Jen-Li Yeo; Merritt Adams; Yee-Ka Agnes Chan; Peter W Gunning; Edna C Hardeman
GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.
Journal of cell science 2012;125(Pt 21):5040-50.
2012: Monique L Howard; Stephen J Palmer; Terence Y C Pang; Thibault Renoir; Matthew W Spitzer; Kylie M Taylor; Geoffrey J Arthurson; Xin Du; Edna C Hardeman; Anthony J Hannan
Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.
Neurobiology of disease 2012;45(3):913-22.
2012: Jocelyn Widagdo; Kylie M Taylor; Peter W Gunning; Edna C Hardeman; Stephen J Palmer
SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation.
PloS one 2012;7(11):e49283.
2010: Lars M Ittner; Yazi D Ke; Fabien Delerue; Mian Bi; Amadeus Gladbach; Janet van Eersel; Heidrun Wölfing; Billy C Chieng; MacDonald J Christie; Ian A Napier; Anne Eckert; Matthias Staufenbiel; Edna C Hardeman; Jürgen Götz
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.
Cell 2010;142(3):387-97.
2010: Stephen J Palmer; Nicole Santucci; Jocelyn Widagdo; Sara J Bontempo; Kylie M Taylor; Enoch S E Tay; Jeff Hook; Frances Lemckert; Peter W Gunning; Edna C Hardeman
Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism.
The Journal of biological chemistry 2010;285(7):4715-24.
2009: Anthony J Kee; Peter W Gunning; Edna C Hardeman
A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle.
Cell motility and the cytoskeleton 2009;66(9):710-20.
2009: Antonio S J Lee; Prathibha Kahatapitiya; Belinda Kramer; Josephine E Joya; Jeff Hook; Renjing Liu; Galina Schevzov; Ian E Alexander; Geoff McCowage; Didier Montarras; Peter W Gunning; Edna C Hardeman
Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.
Stem cells (Dayton, Ohio) 2009;27(5):1098-108.
2009: Anthony J Kee; Peter W Gunning; Edna C Hardeman
Diverse roles of the actin cytoskeleton in striated muscle.
Journal of muscle research and cell motility 2009;30(5-6):187-97.
2009: Nicole Vlahovich; Anthony J Kee; Chris Van der Poel; Emma Kettle; Delia Hernandez-Deviez; Christine Lucas; Gordon S Lynch; Robert Parton; Peter W Gunning; Edna C Hardeman
Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle.
Molecular biology of the cell 2009;20(1):400-9.
2008: Andy C-M Chang; Jeff Hook; Frances A Lemckert; Michelle M McDonald; Mai-Anh T Nguyen; Edna C Hardeman; David G Little; Peter W Gunning; Roger R Reddel
The murine stanniocalcin 2 gene is a negative regulator of postnatal growth.
Endocrinology 2008;149(5):2403-10.
2008: Daniel G MacArthur; Jane T Seto; Stephen Chan; Kate G R Quinlan; Joanna M Raftery; Nigel Turner; Megan D Nicholson; Anthony J Kee; Edna C Hardeman; Peter W Gunning; Gregory J Cooney; Stewart I Head; Nan Yang; Kathryn N North
An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance.
Human molecular genetics 2008;17(8):1076-86.
2008: Galina Schevzov; Thomas Fath; Bernadette Vrhovski; Nicole Vlahovich; Sudarsan Rajan; Jeff Hook; Josephine E Joya; Frances A Lemckert; Franz Puttur; Jim J-C Lin; Edna C Hardeman; David F Wieczorek; Geraldine M O'Neill; Peter W Gunning
Divergent regulation of the sarcomere and the cytoskeleton.
The Journal of biological chemistry 2008;283(1):275-83.
2008: Anthony J Kee; Edna C Hardeman
Tropomyosins in skeletal muscle diseases.
Advances in experimental medicine and biology 2008;644():143-57.
2008: Mai-Anh T Nguyen; Edna C Hardeman
Mouse models for thin filament disease.
Advances in experimental medicine and biology 2008;642():66-77.
2008: Peter W Gunning; Geraldine O'Neill; Edna C Hardeman
Tropomyosin-based regulation of the actin cytoskeleton in time and space.
Physiological reviews 2008;88(1):1-35.
2008: Nicole Vlahovich; Galina Schevzov; Visalini Nair-Shaliker; Biljana Ilkovski; Stanley T Artap; Josephine E Joya; Anthony J Kee; Kathryn N North; Peter W Gunning; Edna C Hardeman
Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle.
Cell motility and the cytoskeleton 2008;65(1):73-85.
2007: Ana Domazetovska; Biljana Ilkovski; Sandra T Cooper; Majid Ghoddusi; Edna C Hardeman; Laurie S Minamide; Peter W Gunning; James R Bamburg; Kathryn N North
Mechanisms underlying intranuclear rod formation.
Brain : a journal of neurology 2007;130(Pt 12):3275-84.
2007: Daniel G MacArthur; Jane T Seto; Joanna M Raftery; Kate G Quinlan; Gavin A Huttley; Jeff W Hook; Frances A Lemckert; Anthony J Kee; Michael R Edwards; Yemima Berman; Edna C Hardeman; Peter W Gunning; Simon Easteal; Nan Yang; Kathryn N North
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans.
Nature genetics 2007;39(10):1261-5.
2007: Wan Chen; Patricia A Ruell; Majid Ghoddusi; Anthony J Kee; Edna C Hardeman; Kylie M Hoffman; Martin W Thompson
Ultrastructural changes and sarcoplasmic reticulum Ca2+ regulation in red vastus muscle following eccentric exercise in the rat.
Experimental physiology 2007;92(2):437-47.
2007: Stephen J Palmer; Enoch S E Tay; Nicole Santucci; Thi Thu Cuc Bach; Jeff Hook; Frances A Lemckert; Robyn V Jamieson; Peter W Gunnning; Edna C Hardeman
Expression of Gtf2ird1, the Williams syndrome-associated gene, during mouse development.
Gene expression patterns : GEP 2007;7(4):396-404.
2006: Despina Sanoudou; Mark Corbett; Mei Han; Majid Ghoddusi; Mai-Anh T Nguyen; Nicole Vlahovich; Edna C Hardeman; Alan H Beggs
Skeletal muscle repair in a mouse model of nemaline myopathy.
Human molecular genetics 2006;15(17):2603-12.
2006: Tanya Butler; Carol G Au; Baoxue Yang; Jonathan R Egan; Yee Mun Tan; Edna C Hardeman; Kathryn N North; A S Verkman; David S Winlaw
Cardiac aquaporin expression in humans, rats, and mice.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H705-13.
2006: Laura L Issa; Stephen J Palmer; Kim L Guven; Nicole Santucci; Vanessa R M Hodgson; Kata Popovic; Josephine E Joya; Edna C Hardeman
MusTRD can regulate postnatal fiber-specific expression.
Developmental biology 2006;293(1):104-15.
2006: Meagan J McGrath; Denny Luke Cottle; Mai-Anh Nguyen; Jennifer M Dyson; Imogen D Coghill; Paul A Robinson; Melissa Holdsworth; Belinda Cowling; Edna C Hardeman; Christina A Mitchell; Susan Brown
Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.
The Journal of biological chemistry 2006;281(11):7666-83.
2005: Galina Schevzov; Nicole S Bryce; Rowena Almonte-Baldonado; Josephine E Joya; Jim J-C Lin; Edna C Hardeman; Ron P Weinberger; Peter W Gunning
Specific features of neuronal size and shape are regulated by tropomyosin isoforms.
Molecular biology of the cell 2005;16(7):3425-37.
2005: Peter W Gunning; Galina Schevzov; Anthony J Kee; Edna C Hardeman
Tropomyosin isoforms: divining rods for actin cytoskeleton function.
Trends in cell biology 2005;15(6):333-41.
2005: Mark Corbett; P Anthony Akkari; Ana Domazetovska; Sandra T Cooper; Kathryn N North; Nigel G Laing; Peter W Gunning; Edna C Hardeman
An alphaTropomyosin mutation alters dimer preference in nemaline myopathy.
Annals of neurology 2005;57(1):42-9.
2004: Josephine E Joya; Anthony J Kee; Visalini Nair-Shalliker; Majid Ghoddusi; Mai-Anh T Nguyen; Pradeep Luther; Edna C Hardeman
Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofiber repair mechanism.
Human molecular genetics 2004;13(21):2633-45.
2004: Visalini Nair-Shalliker; Anthony J Kee; Josephine E Joya; Christine A Lucas; Joseph F Y Hoh; Edna C Hardeman
Myofiber adaptational response to exercise in a mouse model of nemaline myopathy.
Muscle & nerve 2004;30(4):470-80.
2004: Anthony J Kee; Galina Schevzov; Visalini Nair-Shalliker; C Stephen Robinson; Bernadette Vrhovski; Majid Ghoddusi; Min Ru Qiu; Jim J-C Lin; Ron P Weinberger; Peter W Gunning; Edna C Hardeman
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.
The Journal of cell biology 2004;166(5):685-96.
2004: Sandra T Cooper; A L Maxwell; Eddy Kizana; Majid Ghoddusi; Edna C Hardeman; I E Alexander; D G Allen; Kathryn N North
C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression.
Cell motility and the cytoskeleton 2004;58(3):200-11.
2003: Patsie Polly; Leila M Haddadi; Laura L Issa; Nanthakumar Subramaniam; Stephen J Palmer; Enoch S E Tay; Edna C Hardeman
hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer.
The Journal of biological chemistry 2003;278(38):36603-10.
2003: Enoch S E Tay; Kim L Guven; Nanthakumar Subramaniam; Patsie Polly; Laura L Issa; Peter W Gunning; Edna C Hardeman
Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle promoter activity.
The Biochemical journal 2003;374(Pt 2):359-67.
2003: Nicole S Bryce; Galina Schevzov; Vicki Ferguson; Justin Percival; Jim J-C Lin; Fumio Matsumura; James R Bamburg; Peter L Jeffrey; Edna C Hardeman; Peter W Gunning; Ron P Weinberger
Specification of actin filament function and molecular composition by tropomyosin isoforms.
Molecular biology of the cell 2003;14(3):1002-16.
2001: Biljana Ilkovski; Sandra T Cooper; K Nowak; Monique M Ryan; Nan Yang; C Schnell; Hayley J Durling; L G Roddick; I Wilkinson; Andrew J Kornberg; K J Collins; G Wallace; Peter W Gunning; Edna C Hardeman; Nigel G Laing; Kathryn N North
Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene.
American journal of human genetics 2001;68(6):1333-43.
2001: Mark Corbett; C Stephen Robinson; G F Dunglison; Nan Yang; Josephine E Joya; A W Stewart; C Schnell; Peter W Gunning; Kathryn N North; Edna C Hardeman
A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy.
Human molecular genetics 2001;10(4):317-28.
2001: P W Gunning; Vicki Ferguson; K J Brennan; Edna C Hardeman
Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.
Journal of cell science 2001;114(Pt 3):513-24.
1998: Peter W Gunning; Edna C Hardeman; Peter L Jeffrey; Ron P Weinberger
Creating intracellular structural domains: spatial segregation of actin and tropomyosin isoforms in neurons.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(11):892-900.
1998: J V O'Mahoney; Kim L Guven; J Lin; Josephine E Joya; C Stephen Robinson; R P Wade; Edna C Hardeman
Identification of a novel slow-muscle-fiber enhancer binding protein, MusTRD1.
Molecular and cellular biology 1998;18(11):6641-52.
1998: S Newlands; L K Levitt; C Stephen Robinson; A B Karpf; Vanessa R M Hodgson; R P Wade; Edna C Hardeman
Transcription occurs in pulses in muscle fibers.
Genes & development 1998;12(17):2748-58.
1998: DS Criswell; Vanessa R M Hodgson; Edna C Hardeman; Frank W Booth
Nerve-responsive troponin I slow promoter does not respond to unloading.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;84(3):1083-7.
1998: Peter W Gunning; Ron P Weinberger; Peter L Jeffrey; Edna C Hardeman
Isoform sorting and the creation of intracellular compartments.
Annual review of cell and developmental biology 1998;14():339-72.
1997: T Collins; Josephine E Joya; R M Arkell; Vicki Ferguson; Edna C Hardeman
Reappearance of the minor alpha-sarcomeric actins in postnatal muscle.
The American journal of physiology 1997;273(6 Pt 1):C1801-10.
1997: JV Coumans; T Yeoh; R K Seeto; Anne Keogh; K Brennan; Peter W Gunning; Edna C Hardeman; Cristobal G dos Remedios
Variations in the relative mRNA levels of actins and myosin heavy chains do not produce corresponding differences in their proteins in the adult human heart.
Journal of molecular and cellular cardiology 1997;29(3):895-905.
1997: Peter W Gunning; Vicki Ferguson; K Brennan; Edna C Hardeman
Impact of alpha-skeletal actin but not alpha-cardiac actin on myoblast morphology.
Cell structure and function 1997;22(1):173-9.
1996: Cristobal G dos Remedios; D A Berry; L K Carter; J V Coumans; MY Heinke; P C Kiessling; R K Seeto; T Thorvaldson; T Trahair; T Yeoh; M Yao; Peter W Gunning; Edna C Hardeman; Ian Humphery-Smith; D Naidoo; Anne Keogh
Different electrophoretic techniques produce conflicting data in the analysis of myocardial samples from dilated cardiomyopathy patients: protein levels do not necessarily reflect mRNA levels.
Electrophoresis 1996;17(1):235-8.
1995: L K Levitt; J V O'Mahoney; K J Brennan; Josephine E Joya; L Zhu; R P Wade; Edna C Hardeman
The human troponin I slow promoter directs slow fiber-specific expression in transgenic mice.
DNA and cell biology 1995;14(7):599-607.
1995: S J Corin; L K Levitt; J V O'Mahoney; Josephine E Joya; Edna C Hardeman; R Wade
Delineation of a slow-twitch-myofiber-specific transcriptional element by using in vivo somatic gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6185-9.
1995: L Zhu; G E Lyons; O Juhasz; Josephine E Joya; Edna C Hardeman; R Wade
Developmental regulation of troponin I isoform genes in striated muscles of transgenic mice.
Developmental biology 1995;169(2):487-503.
1995: K A Esser; Edna C Hardeman
Changes in contractile protein mRNA accumulation in response to spaceflight.
The American journal of physiology 1995;268(2 Pt 1):C466-71.
1994: Sally L Dunwoodie; Josephine E Joya; R M Arkell; Edna C Hardeman
Multiple regions of the human cardiac actin gene are necessary for maturation-based expression in striated muscle.
The Journal of biological chemistry 1994;269(16):12212-9.
1993: K Esser; Peter W Gunning; Edna C Hardeman
Nerve-dependent and -independent patterns of mRNA expression in regenerating skeletal muscle.
Developmental biology 1993;159(1):173-83.
1993: K J Brennan; Edna C Hardeman
Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice.
The Journal of biological chemistry 1993;268(1):719-25.
1993: C J Sutherland; K A Esser; V L Elsom; M L Gordon; Edna C Hardeman
Identification of a program of contractile protein gene expression initiated upon skeletal muscle differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists 1993;196(1):25-36.
1992: D Hailstones; P Barton; P Chan-Thomas; S Sasse; C Sutherland; Edna C Hardeman; Peter W Gunning
Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development.
The Journal of biological chemistry 1992;267(32):23295-300.
1991: Peter W Gunning; Edna C Hardeman
Multiple mechanisms regulate muscle fiber diversity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(15):3064-70.
1991: C J Sutherland; V L Elsom; M L Gordon; Sally L Dunwoodie; Edna C Hardeman
Coordination of skeletal muscle gene expression occurs late in mammalian development.
Developmental biology 1991;146(1):167-78.
1990: R Wade; C Sutherland; R Gahlmann; Larry Kedes; Edna C Hardeman; Peter W Gunning
Regulation of contractile protein gene family mRNA pool sizes during myogenesis.
Developmental biology 1990;142(2):270-82.
1990: Peter W Gunning; M Gordon; R Wade; R Gahlmann; C S Lin; Edna C Hardeman
Differential control of tropomyosin mRNA levels during myogenesis suggests the existence of an isoform competition-autoregulatory compensation control mechanism.
Developmental biology 1990;138(2):443-53.
1990: Keith A Webster; P Gunning; Edna C Hardeman; Douglas C Wallace; Larry Kedes
Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts.
Journal of cellular physiology 1990;142(3):566-73.
1988: Edna C Hardeman; A Minty; P Benton-Vosman; Larry Kedes; Helen M Blau
In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function.
The Journal of cell biology 1988;106(4):1027-34.
1987: Peter W Gunning; Edna C Hardeman; R Wade; P Ponte; W Bains; Helen M Blau; Larry Kedes
Differential patterns of transcript accumulation during human myogenesis.
Molecular and cellular biology 1987;7(11):4100-14.
1986: Edna C Hardeman; C P Chiu; A Minty; Helen M Blau
The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced.
Cell 1986;47(1):123-30.
1985: Helen M Blau; Grace K Pavlath; Edna C Hardeman; C P Chiu; L Silberstein; S G Webster; S C Miller; C Webster
Plasticity of the differentiated state.
Science (New York, N.Y.) 1985;230(4727):758-66.
1985: J C Garrison; Edna C Hardeman; R Wade; Larry Kedes; P Gunning
Isolation of full-length cDNAs encoding abundant adult human skeletal muscle mRNAs.
Gene 1985;38(1-3):177-88.