FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kendall Harden

Research Profile

Chemicals & Drugs

Anatomy

Concepts & Ideas

Kinetics

Co-author Network

Publications

TOP 3
Weigang Huang; John Sondek; Matthew Barrett; Nicole Hajicek; T Kendall Harden; Stephanie Hicks; Qisheng Zhang
Small molecule inhibitors of phospholipase C from a novel high-throughput screen.
Hashem Dbouk; T Kendall Harden; Christian Harteneck; Christine Hsueh; Bassem D Khalil; Bernd Nürnberg; Olga Perisic; Rachel S Salamon; Peter R Shepherd; Aliaksei Shymanets; Alan V Smrcka; Chinmay Surve; Ronald Taussig; Oscar Vadas; Gary L Waldo; Roger L Williams; Mathew O Barrett; Anne R Bresnick; John E Burke; Jonathan M Backer
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.
Juliana I Sesma; Natacha Steinckwich-Besancon; Hong Dang; Rafael García-Mata; T Kendall Harden; Silvia M Kreda; Eduardo R Lazarowski
The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kendall Harden (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Weigang Huang; John Sondek; Matthew Barrett; Nicole Hajicek; T Kendall Harden; Stephanie Hicks; Qisheng Zhang
Small molecule inhibitors of phospholipase C from a novel high-throughput screen.
The Journal of biological chemistry 2013;288(8):5840-8.
2012: Hashem Dbouk; T Kendall Harden; Christian Harteneck; Christine Hsueh; Bassem D Khalil; Bernd Nürnberg; Olga Perisic; Rachel S Salamon; Peter R Shepherd; Aliaksei Shymanets; Alan V Smrcka; Chinmay Surve; Ronald Taussig; Oscar Vadas; Gary L Waldo; Roger L Williams; Mathew O Barrett; Anne R Bresnick; John E Burke; Jonathan M Backer
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.
Science signaling 2012;5(253):ra89.
2012: Juliana I Sesma; Natacha Steinckwich-Besancon; Hong Dang; Rafael García-Mata; T Kendall Harden; Silvia M Kreda; Eduardo R Lazarowski
The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.
American journal of physiology. Cell physiology 2012;303(5):C490-8.
2012: Xiaoyang Wang; Matthew Barrett; T Kendall Harden; John Sondek; Qisheng Zhang
Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.
Biochemistry 2012;51(26):5300-6.
2012: Aurelie Gresset; John Sondek; T Kendall Harden
The phospholipase C isozymes and their regulation.
Sub-cellular biochemistry 2012;58():61-94.
2011: T Kendall Harden; Stephanie N Hicks; Gary L Waldo; John Sondek
Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes.
Chemical reviews 2011;111(10):6120-9.
2011: Erin J Friedman; T Kendall Harden; Stephanie N Hicks; Kun Jiang; Iva Perovic; Thomas C Pochapsky; Brenda Temple; Helen X Wang; Aditi Deshpande; Alan M Jones
Acireductone dioxygenase 1 (ARD1) is an effector of the heterotrimeric G protein beta subunit in Arabidopsis.
The Journal of biological chemistry 2011;286(34):30107-18.
2011: Hiroshi Maruoka; M P Suresh Jayasekara; Nathaniel Kim; Matthew O Barrett; Stefano Costanzi; Sonia De Castro; Derek A Franklin; T Kendall Harden; Kenneth Alan Jacobson
Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
Journal of medicinal chemistry 2011;54(12):4018-33.
2011: Aidong Qi; Dayle Houston-Cohen; Isabella Naruszewicz; T Kendall Harden; Robert A Nicholas
Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells.
British journal of pharmacology 2011;162(6):1304-13.
2011: Ivar von Kügelgen; T Kendall Harden
Molecular pharmacology, physiology, and structure of the P2Y receptors.
Advances in pharmacology (San Diego, Calif.) 2011;61():373-415.
2010: Gary L Waldo; Tiffany K Ricks; Stephanie N Hicks; Matthew L Cheever; Takeharu Kawano; Kazuhito Tsuboi; Xiaoyue Wang; Craig Montell; Tohru Kozasa; John Sondek; T Kendall Harden
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex.
Science (New York, N.Y.) 2010;330(6006):974-80.
2010: Aurelie Gresset; Stephanie N Hicks; T Kendall Harden; John Sondek
Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.
The Journal of biological chemistry 2010;285(46):35836-47.
2010: Philippe Ohlmann; Sonia de Castro; Garth G Brown; Christian Gachet; Kenneth Alan Jacobson; T Kendall Harden
Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500).
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;62(4):344-51.
2010: Sonia De Castro; Hiroshi Maruoka; Kunlun Hong; S Michael Kilbey; Stefano Costanzi; Béatrice Hechler; Garth G Brown; Christian Gachet; T Kendall Harden; Kenneth Alan Jacobson
Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.
Bioconjugate chemistry 2010;21(7):1190-205.
2010: Samuel C Wolff; Ai-Dong Qi; T Kendall Harden; Robert A Nicholas
Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal.
Journal of cell science 2010;123(Pt 14):2512-20.
2010: Hiroshi Maruoka; Matthew O Barrett; Hyojin Ko; Dilip K Tosh; Artem Melman; Lauren E Burianek; Ramachandran Balasubramanian; Barkin Berk; Stefano Costanzi; T Kendall Harden; Kenneth Alan Jacobson
Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.
Journal of medicinal chemistry 2010;53(11):4488-501.
2010: T Kendall Harden; J I Sesma; I P Fricks; Eduardo R Lazarowski
Signalling and pharmacological properties of the P2Y receptor.
Acta physiologica (Oxford, England) 2010;199(2):149-60.
2010: Dilip K Tosh; Lena S Yoo; Moshe Chinn; Kunlun Hong; S Michael Kilbey; Matthew O Barrett; Ingrid P Fricks; T Kendall Harden; Zhan-Guo Gao; Kenneth Alan Jacobson
Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.
Bioconjugate chemistry 2010;21(2):372-84.
2010: Arijit Das; Hyojin Ko; Lauren E Burianek; Matthew O Barrett; T Kendall Harden; Kenneth Alan Jacobson
Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
Journal of medicinal chemistry 2010;53(1):471-80.
2009: Rhonda L Carter; Ingrid P Fricks; Matthew O Barrett; Lauren E Burianek; Yixing Zhou; Hyojin Ko; Arijit Das; Kenneth Alan Jacobson; Eduardo R Lazarowski; T Kendall Harden
Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.
Molecular pharmacology 2009;76(6):1341-8.
2009: Stefano Costanzi; Irina G Tikhonova; T Kendall Harden; Kenneth Alan Jacobson
Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands.
Journal of computer-aided molecular design 2009;23(11):747-54.
2009: Michael R Elliott; Faraaz B Chekeni; Paul Trampont; Eduardo R Lazarowski; Alexandra Kadl; Scott F Walk; Daeho Park; Robin I Woodson; Marina Ostankovich; Poonam Sharma; Jeffrey J Lysiak; T Kendall Harden; Norbert Leitinger; Kodi S Ravichandran
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
Nature 2009;461(7261):282-6.
2009: Arijit Das; Yixing Zhou; Andrei A Ivanov; Rhonda L Carter; T Kendall Harden; Kenneth Alan Jacobson
Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition.
Bioconjugate chemistry 2009;20(8):1650-9.
2009: Hyojin Ko; Arijit Das; Rhonda L Carter; Ingrid Fricks; Yixing Zhou; Andrei A Ivanov; Artem Melman; Bhalchandra V Joshi; Pavol Kovác; Jan Hajduch; Kenneth L Kirk; T Kendall Harden; Kenneth Alan Jacobson
Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.
Bioorganic & medicinal chemistry 2009;17(14):5298-311.
2009: Ingrid Fricks; Rhonda L Carter; Eduardo R Lazarowski; T Kendall Harden
Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.
The Journal of pharmacology and experimental therapeutics 2009;330(1):162-8.
2009: T Kendall Harden; Stephanie Hicks; John Sondek
Phospholipase C isozymes as effectors of Ras superfamily GTPases.
Journal of lipid research 2009;50 Suppl():S243-8.
2009: Jiyoung Y Cha; Savitri Maddileti; Natalia Y Mitin; T Kendall Harden; Channing J Der
Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.
The Journal of biological chemistry 2009;284(10):6227-40.
2009: Kenneth Alan Jacobson; Andrei A Ivanov; Sonia De Castro; T Kendall Harden; Hyojin Ko
Development of selective agonists and antagonists of P2Y receptors.
Purinergic signalling 2009;5(1):75-89.
2008: Jason Seifert; Yixing Zhou; Stephanie Hicks; John Sondek; T Kendall Harden
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases.
The Journal of biological chemistry 2008;283(44):29690-8.
2008: Stephanie Hicks; Mark R Jezyk; Svetlana Gershburg; Jason Seifert; T Kendall Harden; John Sondek
General and versatile autoinhibition of PLC isozymes.
Molecular cell 2008;31(3):383-94.
2008: Dayle Houston; Stefano Costanzi; Kenneth Alan Jacobson; T Kendall Harden
Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.
Combinatorial chemistry & high throughput screening 2008;11(6):410-9.
2008: Hyojin Ko; Rhonda L Carter; Liesbet Cosyn; Riccardo Petrelli; Sonia De Castro; Pedro Besada; Yixing Zhou; Loredana Cappellacci; Palmarisa Franchetti; Mario Grifantini; Serge Van Calenbergh; T Kendall Harden; Kenneth Alan Jacobson
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Bioorganic & medicinal chemistry 2008;16(12):6319-32.
2008: Ingrid Fricks; Savitri Maddileti; Rhonda L Carter; Eduardo R Lazarowski; Robert A Nicholas; Kenneth Alan Jacobson; T Kendall Harden
UDP is a competitive antagonist at the human P2Y14 receptor.
The Journal of pharmacology and experimental therapeutics 2008;325(2):588-94.
2008: Kevin D. Healy; Louis Hodgson; Tai-Young Kim; Adam Shutes; Savitri Maddileti; Rudy L Juliano; Klaus M Hahn; T Kendall Harden; Yung-Jue Bang; Channing J Der
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.
Molecular carcinogenesis 2008;47(5):326-37.
2008: Yixing Zhou; John Sondek; T Kendall Harden
Activation of human phospholipase C-eta2 by Gbetagamma.
Biochemistry 2008;47(15):4410-7.
2008: Matthew L. Cheever; Jason T Snyder; Svetlana Gershburg; David Siderovski; T Kendall Harden; John Sondek
Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nature structural & molecular biology 2008;15(2):155-62.
2007: Stefano Costanzi; Irina G Tikhonova; Michihiro Ohno; Eun Joo Roh; Bhalchandra V Joshi; Anny-Odile Colson; Dayle Houston; Savitri Maddileti; T Kendall Harden; Kenneth Alan Jacobson
P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring.
Journal of medicinal chemistry 2007;50(14):3229-41.
2007: Hyojin Ko; Ingrid Fricks; Andrei A Ivanov; T Kendall Harden; Kenneth Alan Jacobson
Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor.
Journal of medicinal chemistry 2007;50(9):2030-9.
2007: Andrei A Ivanov; Hyojin Ko; Liesbet Cosyn; Savitri Maddileti; Pedro Besada; Ingrid Fricks; Stefano Costanzi; T Kendall Harden; Serge Van Calenbergh; Kenneth Alan Jacobson
Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.
Journal of medicinal chemistry 2007;50(6):1166-76.
2006: Mark R Jezyk; Jason T Snyder; Svetlana Gershberg; David K Worthylake; T Kendall Harden; John Sondek
Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nature structural & molecular biology 2006;13(12):1135-40.
2006: Pedro Besada; Dae Hong Shin; Stefano Costanzi; Hyojin Ko; Christophe Mathé; Julien Gagneron; Gilles Gosselin; Savitri Maddileti; T Kendall Harden; Kenneth Alan Jacobson
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
Journal of medicinal chemistry 2006;49(18):5532-43.
2006: Melinda D Hains; Michele R Wing; Savitri Maddileti; David Siderovski; T Kendall Harden
Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors.
Molecular pharmacology 2006;69(6):2068-75.
2006: David M Bourdon; Sanjoy Mahanty; Kenneth Alan Jacobson; J L Boyer; T Kendall Harden
(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.
Journal of thrombosis and haemostasis : JTH 2006;4(4):861-8.
2006: Dayle Houston; Michihiro Ohno; Robert A Nicholas; Kenneth Alan Jacobson; T Kendall Harden
[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.
British journal of pharmacology 2006;147(5):459-67.
2006: Kenneth Alan Jacobson; Stefano Costanzi; Andrei A Ivanov; Susanna Tchilibon; Pedro Besada; Zhan-Guo Gao; Savitri Maddileti; T Kendall Harden
Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.
Biochemical pharmacology 2006;71(4):540-9.
2006: David M Bourdon; Michele R Wing; Earl B Edwards; John Sondek; T Kendall Harden
Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system.
Methods in enzymology 2006;406():489-99.
2006: Jason T Snyder; Mark R Jezyk; Svetlana Gershburg; T Kendall Harden; John Sondek
Regulation of PLCbeta isoforms by Rac.
Methods in enzymology 2006;406():272-80.
2006: Jason Seifert; Jason T Snyder; John Sondek; T Kendall Harden
Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles.
Methods in enzymology 2006;406():260-71.
2006: T Kendall Harden; John Sondek
Regulation of phospholipase C isozymes by ras superfamily GTPases.
Annual review of pharmacology and toxicology 2006;46():355-79.
2005: Stefano Costanzi; Bhalchandra V Joshi; Savitri Maddileti; Liaman Mamedova; Maria J Gonzalez-Moa; Victor E Marquez; T Kendall Harden; Kenneth Alan Jacobson
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
Journal of medicinal chemistry 2005;48(26):8108-11.
2005: Yixing Zhou; Michele R Wing; John Sondek; T Kendall Harden
Molecular cloning and characterization of PLC-eta2.
The Biochemical journal 2005;391(Pt 3):667-76.
2005: Christopher A Johnston; Francis S Willard; Mark R Jezyk; Zoey Fredericks; Erik T Bodor; Miller B Jones; Rainer Blaesius; Val Watts; T Kendall Harden; John Sondek; J Kevin Ramer; David Siderovski
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.
Structure (London, England : 1993) 2005;13(7):1069-80.
2005: Samuel C Wolff; Aidong Qi; T Kendall Harden; Robert A Nicholas
Polarized expression of human P2Y receptors in epithelial cells from kidney, lung, and colon.
American journal of physiology. Cell physiology 2005;288(3):C624-32.
2005: Claudia Alvarado-Castillo; T Kendall Harden; José L Boyer
Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2.
Molecular pharmacology 2005;67(1):114-22.
2004: Aidong Qi; T Kendall Harden; Robert A Nicholas
GPR80/99, proposed to be the P2Y(15) receptor activated by adenosine and AMP, is not a P2Y receptor.
Purinergic signalling 2004;1(1):67-74.
2004: Erik T Bodor; Gary L Waldo; Rainer Blaesius; T Kendall Harden
Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins.
Purinergic signalling 2004;1(1):43-9.
2004: Mariya Chhatriwala; R Gnana Ravi; Roshni I Patel; Jose L Boyer; Kenneth Alan Jacobson; T Kendall Harden
Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1038-43.
2004: Marco Cattaneo; Anna Lecchi; Michihiro Ohno; Bhalchandra V Joshi; Pedro Besada; Susanna Tchilibon; Rossana Lombardi; Norbert Bischofberger; T Kendall Harden; Kenneth Alan Jacobson
Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor.
Biochemical pharmacology 2004;68(10):1995-2002.
2004: Jason Seifert; Michele R Wing; Jason T Snyder; Svetlana Gershburg; John Sondek; T Kendall Harden
RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism.
The Journal of biological chemistry 2004;279(46):47992-7.
2004: Michihiro Ohno; Stefano Costanzi; Hak-Sung Kim; Veerle Kempeneers; Karen Vastmans; Piet Herdewijn; Savitri Maddileti; Zhan-Guo Gao; T Kendall Harden; Kenneth Alan Jacobson
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.
Bioorganic & medicinal chemistry 2004;12(21):5619-30.
2004: Yuh-Lin Wu; Shelley Hooks Pence; T Kendall Harden; Henrik G Dohlman
Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein alpha subunit.
The Journal of biological chemistry 2004;279(34):35287-97.
2004: Myoung Goo Kim; Erik T Bodor; T Kendall Harden; Harold Kohn
C(8)-substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands.
Bioorganic & medicinal chemistry 2004;12(9):2357-67.
2004: Christopher L Herold; Aidong Qi; T Kendall Harden; Robert A Nicholas
Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.
The Journal of biological chemistry 2004;279(12):11456-64.
2004: Gary L Waldo; T Kendall Harden
Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor.
Molecular pharmacology 2004;65(2):426-36.
2004: Shelley Hooks Pence; T Kendall Harden
Purification and in vitro functional analysis of R7 subfamily RGS proteins in complex with Gbeta5.
Methods in enzymology 2004;390():163-77.
2004: Melinda D Hains; David Siderovski; T Kendall Harden
Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling.
Methods in enzymology 2004;389():71-88.
2003: Hak-Sung Kim; Michihiro Ohno; Bin Xu; Hea Ok Kim; Yongseok Choi; Xiao-Duo Ji; Savitri Maddileti; Victor E Marquez; T Kendall Harden; Kenneth Alan Jacobson
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
Journal of medicinal chemistry 2003;46(23):4974-87.
2003: Erik T Bodor; Gary L Waldo; Shelley Hooks Pence; James Corbitt; José L Boyer; T Kendall Harden
Purification and functional reconstitution of the human P2Y12 receptor.
Molecular pharmacology 2003;64(5):1210-6.
2003: Michele R Wing; Jason T Snyder; John Sondek; T Kendall Harden
Direct activation of phospholipase C-epsilon by Rho.
The Journal of biological chemistry 2003;278(42):41253-8.
2003: Jesus Mateo; Silvia Kreda; Christopher E Henry; T Kendall Harden; José L Boyer
Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme.
The Journal of biological chemistry 2003;278(41):39960-8.
2003: Eduardo R Lazarowski; Richard C Boucher; T Kendall Harden
Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules.
Molecular pharmacology 2003;64(4):785-95.
2003: Michele R Wing; David M Bourdon; T Kendall Harden
PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling.
Molecular interventions 2003;3(5):273-80.
2003: Jason T Snyder; Alex U Singer; Michele R Wing; T Kendall Harden; John Sondek
The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.
The Journal of biological chemistry 2003;278(23):21099-104.
2003: Myoung Goo Kim; Erik T Bodor; Chen Wang; T Kendall Harden; Harold Kohn
C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.
Journal of medicinal chemistry 2003;46(11):2216-26.
2003: Eduardo R Lazarowski; Deborah A Shea; Richard C Boucher; T Kendall Harden
Release of cellular UDP-glucose as a potential extracellular signaling molecule.
Molecular pharmacology 2003;63(5):1190-7.
2003: Shelley Hooks Pence; Gary L Waldo; James Corbitt; Erik T Bodor; Andrejs M Krumins; T Kendall Harden
RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity.
The Journal of biological chemistry 2003;278(12):10087-93.
2002: Alfred G Gilman; Melvin I Simon; Henry R Bourne; Bruce A Harris; Rochelle Long; Elliott M Ross; James T Stull; Ronald Taussig; Henry R Bourne; Adam P Arkin; Melanie H Cobb; Jason G Cyster; Peter N Devreotes; James E Ferrell; David A Fruman; Michael Gold; Arthur Weiss; James T Stull; Michael J Berridge; Lewis C Cantley; William A Catterall; Shaun R Coughlin; Eric N Olson; Temple F Smith; Joan S Brugge; David Botstein; Jack E Dixon; Tony Hunter; Robert J Lefkowitz; Anthony J Pawson; Paul W Sternberg; Harold Varmus; Shankar Subramaniam; Robert S Sinkovits; Joshua Li; Dennis Mock; Yuhong Ning; Brian Saunders; Paul C Sternweis; Donald Hilgemann; Richard Scheuermann; Dianne DeCamp; Robert Hsueh; Keng-Mean Lin; Yan Ni; William Seaman; Paul C Simpson; Timothy D O'Connell; Tamara Roach; Melvin I Simon; Sangdun Choi; Pamela Eversole-Cire; Iain Fraser; Marc C Mumby; Yingming Zhao; Deirdre Brekken; Hongjun Shu; Tobias Meyer; Grischa Chandy; Won Do Heo; Jen Liou; Nancy O'Rourke; Mary Verghese; Susanne M Mumby; Heping Han; H Alex Brown; Jeffrey S Forrester; Pavlina Ivanova; Stephen B Milne; Patrick J Casey; T Kendall Harden; Adam P Arkin; John Doyle; Martha Gray; Tobias Meyer; Stephen Michnick; Martin A Schmidt; Mehmet Toner; Roger Y Tsien; Madhusudan Natarajan; Rama Ranganathan; Gilberto R Sambrano
Overview of the Alliance for Cellular Signaling.
Nature 2002;420(6916):703-6.
2002: Gary L Waldo; James Corbitt; José L Boyer; Gnana Ravi; Hak-Sung Kim; Xiao-Duo Ji; James Lacy; Kenneth Alan Jacobson; T Kendall Harden
Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist.
Molecular pharmacology 2002;62(5):1249-57.
2002: Claudia Alvarado-Castillo; Patricia Lozano-Zarain; Jesus Mateo; T Kendall Harden; José L Boyer
A fusion protein of the human P2Y(1) receptor and NTPDase1 exhibits functional activities of the native receptor and ectoenzyme and reduced signaling responses to endogenously released nucleotides.
Molecular pharmacology 2002;62(3):521-8.
2002: R Gnana Ravi; Hak-Sung Kim; Jörg Servos; Herbert Zimmermann; Kyeong Lee; Savitri Maddileti; José L Boyer; T Kendall Harden; Kenneth Alan Jacobson
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.
Journal of medicinal chemistry 2002;45(10):2090-100.
2002: José L Boyer; Mary Adams; R Gnana Ravi; Kenneth Alan Jacobson; T Kendall Harden
2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist.
British journal of pharmacology 2002;135(8):2004-10.
2002: Mingyan Hou; T Kendall Harden; Cynthia M Kuhn; Bo Baldetorp; Eduardo R Lazarowski; William Pendergast; Sebastian Möller; Lars Edvinsson; David Erlinge
UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
American journal of physiology. Heart and circulatory physiology 2002;282(2):H784-92.
2002: Hak-Sung Kim; R Gnana Ravi; Victor E Marquez; Savitri Maddileti; Anna-Karin Wihlborg; David Erlinge; Malin Malmsjö; José L Boyer; T Kendall Harden; Kenneth Alan Jacobson
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Journal of medicinal chemistry 2002;45(1):208-18.
2002: Alex U Singer; Gary L Waldo; T Kendall Harden; John Sondek
A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.
Nature structural biology 2002;9(1):32-6.
2001: Bonita L Blake; Michele R Wing; J Y Zhou; Qiubo Lei; J R Hillmann; CI Behe; R A Morris; T Kendall Harden; Douglas A Bayliss; R J Miller; David Siderovski
G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13).
The Journal of biological chemistry 2001;276(52):49267-74.
2001: Michele R Wing; Dayle Houston; G G Kelley; Channing J Der; David Siderovski; T Kendall Harden
Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits.
The Journal of biological chemistry 2001;276(51):48257-61.
2001: Hak-Sung Kim; Dov Barak; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking.
Journal of medicinal chemistry 2001;44(19):3092-108.
2001: T Kendall Harden; J L Boyer; R W Dougherty
Drug analysis based on signaling responses to G-protein-coupled receptors.
Journal of receptor and signal transduction research 2001;21(2-3):167-90.
2001: A E Brinson; T Kendall Harden
Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.
The Journal of biological chemistry 2001;276(15):11939-48.
2001: Eduardo R Lazarowski; L G Rochelle; Wanda O Neal; Carla M Pedrosa Ribeiro; Barbara R Grubb; V Zhang; T Kendall Harden; Richard C Boucher
Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder.
The Journal of pharmacology and experimental therapeutics 2001;297(1):43-9.
2001: M L Cunningham; Gary L Waldo; Susanne Hollinger; John R Hepler; T Kendall Harden
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
The Journal of biological chemistry 2001;276(8):5438-44.
2001: YC Kim; S G Brown; T Kendall Harden; José L Boyer; George R Dubyak; BF King; Geoffrey Burnstock; Kenneth Alan Jacobson
Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.
Journal of medicinal chemistry 2001;44(3):340-9.
2001: Kenneth Alan Jacobson; Stefano Moro; C Hoffmann; Y C Kim; H S Kim; R G Ravi; T Kendall Harden; J L Boyer
Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):71-5.
2001: Aidong Qi; Charles Kennedy; T Kendall Harden; Robert A Nicholas
Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase.
British journal of pharmacology 2001;132(1):318-26.
2000: Eduardo R Lazarowski; Richard C Boucher; T Kendall Harden
Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations.
The Journal of biological chemistry 2000;275(40):31061-8.
2000: Malin Malmsjö; Mikael Adner; T Kendall Harden; William Pendergast; Lars Edvinsson; David Erlinge
The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery.
British journal of pharmacology 2000;131(1):51-6.
2000: Malin Malmsjö; Mingyan Hou; T Kendall Harden; William Pendergast; Emil Pantev; Lars Edvinsson; David Erlinge
Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5'-O-thiodiphosphate and uridine 5'-O-3-thiotriphosphate.
The Journal of pharmacology and experimental therapeutics 2000;293(3):755-60.
2000: Charles Kennedy; Aidong Qi; Christopher L Herold; T Kendall Harden; Robert A Nicholas
ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Molecular pharmacology 2000;57(5):926-31.
2000: J L Boyer; S M Delaney; D Villanueva; T Kendall Harden
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
Molecular pharmacology 2000;57(4):805-10.
2000: Nandanan Erathodiyil; SY Jang; Stefano Moro; Hea Ok Kim; M A Siddiqui; P Russ; Victor E Marquez; R Busson; Piet Herdewijn; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.
Journal of medicinal chemistry 2000;43(5):829-42.
2000: YC Kim; C Gallo-Rodriguez; SY Jang; Nandanan Erathodiyil; M Adams; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists.
Journal of medicinal chemistry 2000;43(4):746-55.
2000: VIOLETA MUTAFOVA-YAMBOLIEVA; B M Carolan; T Kendall Harden; Kathleen D Keef
Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein.
General pharmacology 2000;34(2):127-36.
1999: Jesus Mateo; T Kendall Harden; J L Boyer
Functional expression of a cDNA encoding a human ecto-ATPase.
British journal of pharmacology 1999;128(2):396-402.
1999: M L Cunningham; T M Filtz; T Kendall Harden
Protein kinase C-promoted inhibition of Galpha(11)-stimulated phospholipase C-beta activity.
Molecular pharmacology 1999;56(2):265-71.
1999: Eduardo R Lazarowski; T Kendall Harden
Quantitation of extracellular UTP using a sensitive enzymatic assay.
British journal of pharmacology 1999;127(5):1272-8.
1999: Chang-Seon Myung; H Yasuda; W W Liu; T Kendall Harden; James C Garrison
Role of isoprenoid lipids on the heterotrimeric G protein gamma subunit in determining effector activation.
The Journal of biological chemistry 1999;274(23):16595-603.
1999: Anthony M Paradiso; H A Brown; H Ye; T Kendall Harden; Richard C Boucher
Heterogeneous responses of cell Ca2+ in human airway epithelium.
Experimental lung research 1999;25(4):277-90.
1999: Chang-Seon Myung; A Paterson; T Kendall Harden; James C Garrison
Development of an assay for phospholipase C using column-reconstituted, extruded phospholipid vesicles.
Analytical biochemistry 1999;270(2):303-13.
1999: C Hoffmann; Stefano Moro; Robert A Nicholas; T Kendall Harden; Kenneth Alan Jacobson
The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.
The Journal of biological chemistry 1999;274(21):14639-47.
1999: Nandanan Erathodiyil; E Camaioni; SY Jang; YC Kim; Gloria Cristalli; Piet Herdewijn; John A Secrist; Kamal N Tiwari; A Mohanram; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
Journal of medicinal chemistry 1999;42(9):1625-38.
1999: T M Filtz; M L Cunningham; K J Stanig; A Paterson; T Kendall Harden
Phosphorylation by protein kinase C decreases catalytic activity of avian phospholipase C-beta.
The Biochemical journal 1999;338 ( Pt 2)():257-64.
1999: T Kendall Harden; Eduardo R Lazarowski
Release of ATP and UTP from astrocytoma cells.
Progress in brain research 1999;120():135-43.
1999: Kenneth Alan Jacobson; C Hoffmann; YC Kim; E Camaioni; Nandanan Erathodiyil; SY Jang; D P Guo; Xiao-Duo Ji; Ivar von Kügelgen; Stefano Moro; A U Ziganshin; Alexey V Rychkov; BF King; S G Brown; Scott S Wildman; Geoffrey Burnstock; José L Boyer; A Mohanram; T Kendall Harden
Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis.
Progress in brain research 1999;120():119-32.
1998: R K Palmer; José L Boyer; JB Schachter; Robert A Nicholas; T Kendall Harden
Agonist action of adenosine triphosphates at the human P2Y1 receptor.
Molecular pharmacology 1998;54(6):1118-23.
1998: Q Li; Melanie Olesky; R K Palmer; T Kendall Harden; Robert A Nicholas
Evidence that the p2y3 receptor is the avian homologue of the mammalian P2Y6 receptor.
Molecular pharmacology 1998;54(3):541-6.
1998: S M Sromek; T Kendall Harden
Agonist-induced internalization of the P2Y2 receptor.
Molecular pharmacology 1998;54(3):485-94.
1998: Kenneth Alan Jacobson; YC Kim; Scott S Wildman; A Mohanram; T Kendall Harden; José L Boyer; BF King; Geoffrey Burnstock
A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors.
Journal of medicinal chemistry 1998;41(13):2201-6.
1998: José L Boyer; A Mohanram; E Camaioni; Kenneth Alan Jacobson; T Kendall Harden
Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.
British journal of pharmacology 1998;124(1):1-3.
1998: Stefano Moro; D Guo; E Camaioni; José L Boyer; T Kendall Harden; Kenneth Alan Jacobson
Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.
Journal of medicinal chemistry 1998;41(9):1456-66.
1998: E Camaioni; José L Boyer; A Mohanram; T Kendall Harden; Kenneth Alan Jacobson
Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.
Journal of medicinal chemistry 1998;41(2):183-90.
1997: José L Boyer; Gary L Waldo; T Kendall Harden
Molecular cloning and expression of an avian G protein-coupled P2Y receptor.
Molecular pharmacology 1997;52(6):928-34.
1997: J B Schachter; J L Boyer; Q Li; Robert A Nicholas; T Kendall Harden
Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C.
British journal of pharmacology 1997;122(6):1021-4.
1997: Eduardo R Lazarowski; L Homolya; Richard C Boucher; T Kendall Harden
Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation.
The Journal of biological chemistry 1997;272(39):24348-54.
1997: JB Schachter; S M Sromek; Robert A Nicholas; T Kendall Harden
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors.
Neuropharmacology 1997;36(9):1181-7.
1997: Q Jiang; D Guo; B X Lee; AM van Rhee; YC Kim; Robert A Nicholas; J B Schachter; T Kendall Harden; Kenneth Alan Jacobson
A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.
Molecular pharmacology 1997;52(3):499-507.
1997: Eduardo R Lazarowski; L Homolya; Richard C Boucher; T Kendall Harden
Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists.
The Journal of biological chemistry 1997;272(33):20402-7.
1997: Q Li; JB Schachter; T Kendall Harden; Robert A Nicholas
The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses.
Biochemical and biophysical research communications 1997;236(2):455-60.
1997: Christopher L Herold; Q Li; JB Schachter; T Kendall Harden; Robert A Nicholas
Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7.
Biochemical and biophysical research communications 1997;235(3):717-21.
1997: J B Schachter; T Kendall Harden
An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor.
British journal of pharmacology 1997;121(2):338-44.
1997: Eduardo R Lazarowski; Anthony M Paradiso; WC Watt; T Kendall Harden; Richard C Boucher
UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2599-603.
1997: Bertil B. Fredholm; M P Abbracchio; G Burnstock; G R Dubyak; T Kendall Harden; Kenneth Alan Jacobson; Ulrich Schwabe; M Williams
Towards a revised nomenclature for P1 and P2 receptors.
Trends in pharmacological sciences 1997;18(3):79-82.
1997: T Kendall Harden; Eduardo R Lazarowski; Richard C Boucher
Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity.
Trends in pharmacological sciences 1997;18(2):43-6.
1997: SR James; A Paterson; T Kendall Harden; R A Demel; C Peter Downes
Dependence of the activity of phospholipase C beta on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation.
Biochemistry 1997;36(4):848-55.
1996: T M Filtz; A Paterson; T Kendall Harden
Purification and G protein subunit regulation of a phospholipase C-beta from Xenopus laevis oocytes.
The Journal of biological chemistry 1996;271(49):31121-6.
1996: Robert A Nicholas; Eduardo R Lazarowski; W C Watt; Q Li; J Boyer; T Kendall Harden
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors.
Journal of autonomic pharmacology 1996;16(6):319-23.
1996: S M O'Grady; E Elmquist; T M Filtz; Robert A Nicholas; T Kendall Harden
A guanine nucleotide-independent inwardly rectifying cation permeability is associated with P2Y1 receptor expression in Xenopus oocytes.
The Journal of biological chemistry 1996;271(46):29080-7.
1996: José L Boyer; T Romero-Avila; JB Schachter; T Kendall Harden
Identification of competitive antagonists of the P2Y1 receptor.
Molecular pharmacology 1996;50(5):1323-9.
1996: M C Galas; T Kendall Harden
Cyclic AMP-induced desensitization of G-protein-regulated phospholipase C in turkey erythrocyte membranes.
European journal of pharmacology 1996;314(1-2):157-64.
1996: José L Boyer; S Siddiqi; B Fischer; T Romero-Avila; Kenneth Alan Jacobson; T Kendall Harden
Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate.
British journal of pharmacology 1996;118(8):1959-64.
1996: Robert A Nicholas; W C Watt; Eduardo R Lazarowski; Q Li; T Kendall Harden
Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.
Molecular pharmacology 1996;50(2):224-9.
1996: G L Waldo; A Paterson; José L Boyer; Robert A Nicholas; T Kendall Harden
Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes.
The Biochemical journal 1996;316 ( Pt 2)():559-68.
1996: JB Schachter; Q Li; José L Boyer; Robert A Nicholas; T Kendall Harden
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.
British journal of pharmacology 1996;118(1):167-73.
1996: SR James; S Smith; A Paterson; T Kendall Harden; C Peter Downes
Time-dependent inhibition of phospholipase C beta-catalysed phosphoinositide hydrolysis: a comparison of different assays.
The Biochemical journal 1996;314 ( Pt 3)():917-21.
1996: Eduardo R Lazarowski; W C Watt; Monroe Stutts; H A Brown; Richard C Boucher; T Kendall Harden
Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors.
British journal of pharmacology 1996;117(1):203-9.
1995: José L Boyer; J W O'Tuel; B Fischer; Kenneth Alan Jacobson; T Kendall Harden
Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors.
British journal of pharmacology 1995;116(6):2611-6.
1995: M C Galas; T Kendall Harden
Receptor-induced heterologous desensitization of receptor-regulated phospholipase C.
European journal of pharmacology 1995;291(2):175-82.
1995: Eduardo R Lazarowski; W C Watt; Monroe Stutts; Richard C Boucher; T Kendall Harden
Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate.
British journal of pharmacology 1995;116(1):1619-27.
1995: A Paterson; José L Boyer; Val Watts; Andrew J Morris; E M Price; T Kendall Harden
Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits.
Cellular signalling 1995;7(7):709-20.
1995: SR James; A Paterson; T Kendall Harden; C Peter Downes
Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps.
The Journal of biological chemistry 1995;270(20):11872-81.
1995: T Kendall Harden; José L Boyer; Robert A Nicholas
P2-purinergic receptors: subtype-associated signaling responses and structure.
Annual review of pharmacology and toxicology 1995;35():541-79.
1994: X H Chen; T Kendall Harden; Robert A Nicholas
Molecular cloning and characterization of a novel beta-adrenergic receptor.
The Journal of biological chemistry 1994;269(40):24810-9.
1994: J L Boyer; I E Zohn; Kenneth Alan Jacobson; T Kendall Harden
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors.
British journal of pharmacology 1994;113(2):614-20.
1994: T M Filtz; Q Li; José L Boyer; Robert A Nicholas; T Kendall Harden
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.
Molecular pharmacology 1994;46(1):8-14.
1994: Bertil B. Fredholm; M P Abbracchio; G Burnstock; J W Daly; T Kendall Harden; Kenneth Alan Jacobson; P Leff; M Williams
Nomenclature and classification of purinoceptors.
Pharmacological reviews 1994;46(2):143-56.
1994: Eduardo R Lazarowski; T Kendall Harden
Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C.
The Journal of biological chemistry 1994;269(16):11830-6.
1994: Eduardo R Lazarowski; Richard C Boucher; T Kendall Harden
Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium.
The American journal of physiology 1994;266(2 Pt 1):C406-15.
1994: José L Boyer; Stephen G Graber; G L Waldo; T Kendall Harden; James C Garrison
Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits.
The Journal of biological chemistry 1994;269(4):2814-9.
1994: G L Waldo; José L Boyer; T Kendall Harden
Purification of phospholipase C-activating G protein, G11, from turkey erythrocytes.
Methods in enzymology 1994;237():182-91.
1994: G L Waldo; Andrew J Morris; T Kendall Harden
Purification of G-protein-regulated phospholipase C from turkey erythrocytes.
Methods in enzymology 1994;238():195-207.
1993: José L Boyer; Eduardo R Lazarowski; X H Chen; T Kendall Harden
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.
The Journal of pharmacology and experimental therapeutics 1993;267(3):1140-6.
1993: B Fischer; José L Boyer; Charles Hoyle; Airat U Ziganshin; A L Brizzolara; G E Knight; J Zimmet; G Burnstock; T Kendall Harden; Kenneth Alan Jacobson
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate.
Journal of medicinal chemistry 1993;36(24):3937-46.
1993: D H Maurice; G L Waldo; Andrew J Morris; Robert A Nicholas; T Kendall Harden
Identification of G alpha 11 as the phospholipase C-activating G-protein of turkey erythrocytes.
The Biochemical journal 1993;290 ( Pt 3)():765-70.
1992: José L Boyer; G L Waldo; T Kendall Harden
Beta gamma-subunit activation of G-protein-regulated phospholipase C.
The Journal of biological chemistry 1992;267(35):25451-6.
1992: Eduardo R Lazarowski; S J Mason; L Clarke; T Kendall Harden; Richard C Boucher
Adenosine receptors on human airway epithelia and their relationship to chloride secretion.
British journal of pharmacology 1992;106(4):774-82.
1992: T Kendall Harden
G-protein-regulated phospholipase C. Identification of component proteins.
Advances in second messenger and phosphoprotein research 1992;26():11-34.
1991: H A Brown; Eduardo R Lazarowski; Richard C Boucher; T Kendall Harden
Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.
Molecular pharmacology 1991;40(5):648-55.
1991: G L Waldo; Andrew J Morris; David Klapper; T Kendall Harden
Receptor- and G-protein-regulated 150-kDa avian phospholipase C: inhibition of enzyme activity by isoenzyme-specific antisera and nonidentity with mammalian phospholipase C isoenzymes established by immunoreactivity and peptide sequence.
Molecular pharmacology 1991;40(4):480-9.
1991: G L Waldo; José L Boyer; Andrew J Morris; T Kendall Harden
Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein.
The Journal of biological chemistry 1991;266(22):14217-25.
1991: R A Jeffs; C L Cooper; T Kendall Harden
Solubilization of a guanine nucleotide-sensitive form of the P2Y-purinergic receptor.
Molecular pharmacology 1991;40(1):85-92.
1991: T Kendall Harden; Andrew J Morris; G L Waldo; C P Downes; José L Boyer
Avian G-protein-regulated phospholipase C.
Biochemical Society transactions 1991;19(2):342-6.
1990: W R Huckle; J R Hepler; S G Rhee; T Kendall Harden; Henry Earp
Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis.
Endocrinology 1990;127(4):1697-705.
1990: J R Hepler; R A Jeffs; W R Huckle; H E Outlaw; S G Rhee; Henry Earp; T Kendall Harden
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
The Biochemical journal 1990;270(2):337-44.
1990: José L Boyer; C L Cooper; T Kendall Harden
[32P]3'-O-(4-benzoyl)benzoyl ATP as a photoaffinity label for a phospholipase C-coupled P2Y-purinergic receptor.
The Journal of biological chemistry 1990;265(23):13515-20.
1990: Andrew J Morris; G L Waldo; C P Downes; T Kendall Harden
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts.
The Journal of biological chemistry 1990;265(23):13508-14.
1990: Andrew J Morris; G L Waldo; C P Downes; T Kendall Harden
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties.
The Journal of biological chemistry 1990;265(23):13501-7.
1990: T Kendall Harden
G protein-dependent regulation of phospholipase C by cell surface receptors.
The American review of respiratory disease 1990;141(3 Pt 2):S119-22.
1990: T Kendall Harden; José L Boyer; H A Brown; C L Cooper; R A Jeffs; M W Martin
Biochemical properties of a P2Y-purinergic receptor.
Annals of the New York Academy of Sciences 1990;603():256-66.
1990: Andrew J Morris; G L Waldo; José L Boyer; J R Hepler; C P Downes; T Kendall Harden
Regulation of phospholipase C.
Society of General Physiologists series 1990;45():61-75.
1989: José L Boyer; T Kendall Harden
Irreversible activation of phospholipase C-coupled P2Y-purinergic receptors by 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate.
Molecular pharmacology 1989;36(6):831-5.
1989: M W Martin; T Kendall Harden
Agonist-induced desensitization of a P2Y-purinergic receptor-regulated phospholipase C.
The Journal of biological chemistry 1989;264(33):19535-9.
1989: J L Boyer; J R Hepler; T Kendall Harden
Hormone and growth factor receptor-mediated regulation of phospholipase C activity.
Trends in pharmacological sciences 1989;10(9):360-4.
1989: J L Boyer; G L Waldo; T Evans; J K Northup; C P Downes; T Kendall Harden
Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits.
The Journal of biological chemistry 1989;264(23):13917-22.
1989: C L Cooper; Andrew J Morris; T Kendall Harden
Guanine nucleotide-sensitive interaction of a radiolabeled agonist with a phospholipase C-linked P2y-purinergic receptor.
The Journal of biological chemistry 1989;264(11):6202-6.
1989: M W Roe; J R Hepler; T Kendall Harden; Brian Herman
Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells.
Journal of cellular physiology 1989;139(1):100-8.
1989: C P Berrie; Phillip T Hawkins; Len R Stephens; T Kendall Harden; C P Downes
Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors.
Molecular pharmacology 1989;35(4):526-32.
1989: José L Boyer; C P Downes; T Kendall Harden
Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides.
The Journal of biological chemistry 1989;264(2):884-90.
1988: S N Abramson; M W Martin; A R Hughes; T Kendall Harden; Kim A Neve; D A Barrett; P B Molinoff
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
Biochemical pharmacology 1988;37(22):4289-97.
1988: C P Downes; C P Berrie; Phillip T Hawkins; Len Stephens; José L Boyer; T Kendall Harden
Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1988;320(1199):267-80.
1988: J R Hepler; Henry Earp; T Kendall Harden
Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.
The Journal of biological chemistry 1988;263(16):7610-9.
1988: T Kendall Harden; Phillip T Hawkins; Len Stephens; José L Boyer; C P Downes
Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes.
The Biochemical journal 1988;252(2):583-93.
1987: Andrew J Morris; C P Downes; T Kendall Harden; Robert H Michell
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin.
The Biochemical journal 1987;248(2):489-93.
1987: J R Hepler; A R Hughes; T Kendall Harden
Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems.
The Biochemical journal 1987;247(3):793-6.
1987: M Liang; M W Martin; T Kendall Harden
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
Molecular pharmacology 1987;32(4):443-9.
1987: G L Waldo; T Evans; E D Fraser; J K Northup; M W Martin; T Kendall Harden
Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go.
The Biochemical journal 1987;246(2):431-9.
1987: T Kendall Harden; Len Stephens; Phillip T Hawkins; C P Downes
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides.
The Journal of biological chemistry 1987;262(19):9057-61.
1987: B S Pallotta; J R Hepler; S A Oglesby; T Kendall Harden
A comparison of calcium-activated potassium channel currents in cell-attached and excised patches.
The Journal of general physiology 1987;89(6):985-97.
1987: J R Hepler; N Nakahata; T W Lovenberg; J DiGuiseppi; Brian Herman; Henry Earp; T Kendall Harden
Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.
The Journal of biological chemistry 1987;262(7):2951-6.
1987: N Nakahata; T Kendall Harden
Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists.
The Biochemical journal 1987;241(2):337-44.
1986: J R Hepler; T Kendall Harden
Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells.
The Biochemical journal 1986;239(1):141-6.
1986: T Kendall Harden; M M Heng; J H Brown
Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment.
Molecular pharmacology 1986;30(3):200-6.
1986: L I Tanner; T Kendall Harden; J N Wells; M W Martin
Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells.
Molecular pharmacology 1986;29(5):455-60.
1986: A R Hughes; T Kendall Harden
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells.
The Journal of pharmacology and experimental therapeutics 1986;237(1):173-8.
1986: N Nakahata; M W Martin; A R Hughes; J R Hepler; T Kendall Harden
H1-histamine receptors on human astrocytoma cells.
Molecular pharmacology 1986;29(2):188-95.
1986: Myron L Toews; G L Waldo; T Kendall Harden; J P Perkins
Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice.
Journal of cyclic nucleotide and protein phosphorylation research 1986;11(1):47-62.
1985: T Evans; J R Hepler; S B Masters; J H Brown; T Kendall Harden
Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization.
The Biochemical journal 1985;232(3):751-7.
1985: T Kendall Harden; L A Petch; Stephen F Traynelis; G L Waldo
Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.
The Journal of biological chemistry 1985;260(24):13060-6.
1985: Gary E Duncan; I A Paul; T Kendall Harden; Robert A Mueller; W E Stumpf; George R Breese
Rapid down regulation of beta adrenergic receptors by combining antidepressant drugs with forced swim: a model of antidepressant-induced neural adaptation.
The Journal of pharmacology and experimental therapeutics 1985;234(2):402-8.
1985: M W Martin; T Evans; T Kendall Harden
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
The Biochemical journal 1985;229(2):539-44.
1985: S B Masters; M W Martin; T Kendall Harden; J H Brown
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization.
The Biochemical journal 1985;227(3):933-7.
1985: R C Doss; N R Kramarcy; T Kendall Harden; J P Perkins
Effects of tunicamycin on the expression of beta-adrenergic receptors in human astrocytoma cells during growth and recovery from agonist-induced down-regulation.
Molecular pharmacology 1985;27(5):507-16.
1985: McHardy Smith; T Kendall Harden
Muscarinic cholinergic receptor-mediated attenuation of adenylate cyclase activity in rat heart membranes.
Journal of cyclic nucleotide and protein phosphorylation research 1985;10(2):197-210.
1985: T Kendall Harden; T Evans; J R Hepler; A R Hughes; M W Martin; Rick B Meeker; McHardy Smith; L I Tanner
Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors.
Advances in cyclic nucleotide and protein phosphorylation research 1985;19():207-20.
1985: T Evans; M W Martin; A R Hughes; T Kendall Harden
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Molecular pharmacology 1985;27(1):32-7.
1984: G L Waldo; R C Doss; J P Perkins; T Kendall Harden
Use of a density shift method to assess beta-adrenergic receptor synthesis during recovery from catecholamine-induced down-regulation in human astrocytoma cells.
Molecular pharmacology 1984;26(3):424-9.
1984: T Evans; McHardy Smith; L I Tanner; T Kendall Harden
Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms.
Molecular pharmacology 1984;26(3):395-404.
1984: Myron L Toews; G L Waldo; T Kendall Harden; J P Perkins
Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.
The Journal of biological chemistry 1984;259(19):11844-50.
1984: A R Hughes; M W Martin; T Kendall Harden
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(18):5680-4.
1984: S B Masters; T Kendall Harden; J H Brown
Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells.
Molecular pharmacology 1984;26(2):149-55.
1984: M W Martin; McHardy Smith; T Kendall Harden
Modulation of muscarinic cholinergic receptor affinity for antagonists in rat heart.
The Journal of pharmacology and experimental therapeutics 1984;230(2):424-30.
1984: T Evans; Kenny Mccarthy; T Kendall Harden
Regulation of cyclic AMP accumulation by peptide hormone receptors in immunocytochemically defined astroglial cells.
Journal of neurochemistry 1984;43(1):131-8.
1984: P A Trimmer; T Evans; McHardy Smith; T Kendall Harden; Kenny Mccarthy
Combination of immunocytochemistry and radioligand receptor assay to identify beta-adrenergic receptor subtypes on astroglia in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(6):1598-606.
1984: L X Cubeddu; G Cloutier; K Gross; R Grippo; L Tanner; L Lerea; M Shakarjian; G Knowlton; M Stat; T Kendall Harden
Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats.
Clinical pharmacology and therapeutics 1984;35(5):576-84.
1984: McHardy Smith; T Kendall Harden
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.
The Journal of pharmacology and experimental therapeutics 1984;228(2):425-33.
1984: J P Perkins; Myron L Toews; T Kendall Harden
Regulation of beta-adrenergic receptors during exposure of astrocytoma cells to catecholamines.
Advances in cyclic nucleotide and protein phosphorylation research 1984;17():37-46.
1983: T Kendall Harden; Rick B Meeker; M W Martin
Interaction of a radiolabeled agonist with cardiac muscarinic cholinergic receptors.
The Journal of pharmacology and experimental therapeutics 1983;227(3):570-7.
1983: G L Waldo; J K Northup; J P Perkins; T Kendall Harden
Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.
The Journal of biological chemistry 1983;258(22):13900-8.
1983: Myron L Toews; T Kendall Harden; J P Perkins
High-affinity binding of agonists to beta-adrenergic receptors on intact cells.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(12):3553-7.
1983: Rick B Meeker; T Kendall Harden
Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation.
Molecular pharmacology 1983;23(2):384-92.
1983: T Kendall Harden
Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.
Pharmacological reviews 1983;35(1):5-32.
1983: R C Frederich; G L Waldo; T Kendall Harden; J P Perkins
Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells.
Journal of cyclic nucleotide and protein phosphorylation research 1983;9(2):103-18.
1983: Stephen Korn; M W Martin; T Kendall Harden
N-Ethylmaleimide-induced alteration in the interaction of agonists with muscarinic cholinergic receptors of rat brain.
The Journal of pharmacology and experimental therapeutics 1983;224(1):118-26.
1982: Rick B Meeker; T Kendall Harden
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.
Molecular pharmacology 1982;22(2):310-9.
1982: T Kendall Harden; Kenny Mccarthy
Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain.
The Journal of pharmacology and experimental therapeutics 1982;222(3):600-5.
1982: T Kendall Harden; A G Scheer; McHardy Smith
Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s).
Molecular pharmacology 1982;21(3):570-80.
1981: R C Doss; J P Perkins; T Kendall Harden
Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis.
The Journal of biological chemistry 1981;256(23):12281-6.
1981: K M Witkin; T Kendall Harden
A sensitive equilibrium binding assay for soluble beta-adrenergic receptors.
Journal of cyclic nucleotide research 1981;7(4):235-46.
1981: Kenny Mccarthy; T Kendall Harden
Identification of two benzodiazepine binding sites on cells cultured from rat cerebral cortex.
The Journal of pharmacology and experimental therapeutics 1981;216(1):183-91.
1981: B B Wolfe; T Kendall Harden
Guanine nucleotides modulate the affinity of antagonists at beta-adrenergic receptors.
Journal of cyclic nucleotide research 1981;7(5):303-12.
1980: T Kendall Harden; C U Cotton; G L Waldo; J K Lutton; J P Perkins
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.
Science (New York, N.Y.) 1980;210(4468):441-3.
1980: Y F Su; T Kendall Harden; J P Perkins
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.
The Journal of biological chemistry 1980;255(15):7410-9.
1980: S J Foster; T Kendall Harden
Dexamethasone increases beta-adrenoceptor density in human astrocytoma cells.
Biochemical pharmacology 1980;29(15):2151-3.
1980: R G Thurman; T Kendall Harden; K Winn
Cyclic AMP and beta-adrenergic receptors during the development of physical dependence on ethanol in the rat.
Advances in experimental medicine and biology 1980;126():145-55.
1979: T Kendall Harden; S J Foster; J P Perkins
Differential expression of components of the adenylate cyclase system during growth of astrocytoma cells in culture.
The Journal of biological chemistry 1979;254(11):4416-22.
1979: W A Hunt; T Kendall Harden; R G Thurman
beta-adrenergic receptor density in brains of ethanol-dependent rats.
Drug and alcohol dependence 1979;4(3-4):327.
1979: J P Perkins; Y F Su; T Kendall Harden
Adaptive changes in the responsiveness of adenylate cyclase to catecholamines.
Drug and alcohol dependence 1979;4(3-4):279-94.
1979: T Kendall Harden; Richard B Mailman; Robert A Mueller; George R Breese
Noradrenergic hyperinnervation reduces the density of beta-adrenergic receptors in rat cerebellum.
Brain research 1979;166(1):194-8.
1979: Y F Su; T Kendall Harden; J P Perkins
Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors.
The Journal of biological chemistry 1979;254(1):38-41.
1979: T Kendall Harden; Y F Su; J P Perkins
Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase.
Journal of cyclic nucleotide research 1979;5(2):99-106.
1978: B B Wolfe; T Kendall Harden; J R Sporn; P B Molinoff
Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.
The Journal of pharmacology and experimental therapeutics 1978;207(2):446-57.
1978: George R Breese; Richard B Mailman; M G Ondrusek; T Kendall Harden; Robert A Mueller
Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3',5'-monophosphate (cGMP).
Life sciences 1978;23(5):533-6.
1978: B H Leichtling; Y F Su; J Wimalasena; T Kendall Harden; B B Wolfe; W D Wicks
Studies of cAMP metabolism in cultured hepatoma cells: presence of functional adenylate cyclase despite low cAMP content and lack of hormonal responsiveness.
Journal of cellular physiology 1978;96(2):215-23.
1978: D L Nelson; T Kendall Harden; P B Molinoff
Adrenergic storage vesicles in rat heart: quantitation of membrane-bound and membrane-enclosed dopamine beta-hydroxylase.
The Journal of pharmacology and experimental therapeutics 1978;205(2):357-65.
1978: G L Johnson; B B Wolfe; T Kendall Harden; P B Molinoff; J P Perkins
Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells.
The Journal of biological chemistry 1978;253(5):1472-80.
1978: G L Johnson; T Kendall Harden; J P Perkins
Regulation of adenosine 3':5'-monophosphate content of rous sarcoma virus-transformed human astrocytoma cells. Effects of cholera toxin on the responsiveness to catecholamines and prostaglandins.
The Journal of biological chemistry 1978;253(5):1465-71.
1978: P B Molinoff; J R Sporn; B B Wolfe; T Kendall Harden
Regulation of beta-adrenergic receptors in the cerebral cortex.
Advances in cyclic nucleotide research 1978;9():465-83.
1978: W D Wicks; B H Leichtling; J Wimalasena; M D Roper; J L Su; Y F Su; S Howell; T Kendall Harden; B B Wolfe
Regulation of cAMP metabolism, protein kinase activation, and specific enzyme synthesis in cultured hepatoma cells.
Advances in cyclic nucleotide research 1978;9():411-24.
1978: J P Perkins; G L Johnson; T Kendall Harden
Drug-induced modification of the responsiveness of adenylate cyclase to hormones.
Advances in cyclic nucleotide research 1978;9():19-32.
1977: J R Sporn; B B Wolfe; T Kendall Harden; P B Molinoff
Supersensitivity in rat cerebral cortex: pre- and postsynaptic effects of 6-hydroxydopamine at noradrenergic synapses.
Molecular pharmacology 1977;13(6):1170-80.
1977: T Kendall Harden; B B Wolfe; J R Sporn; B K Poulos; P B Molinoff
Effects of 6-hydroxydopamine on the development of the beta adrenergic receptor/adenylate cyclase system in rat cerebral cortex.
The Journal of pharmacology and experimental therapeutics 1977;203(1):132-43.
1977: T Kendall Harden; B B Wolfe; J R Sporn; J P Perkins; P B Molinoff
Ontogeny of beta-adrenergic receptors in rat cerebral cortex.
Brain research 1977;125(1):99-108.
1977: B B Wolfe; T Kendall Harden; P B Molinoff
In vitro study of beta-adrenergic receptors.
Annual review of pharmacology and toxicology 1977;17():575-604.
1976: J R Sporn; T Kendall Harden; B B Wolfe; P B Molinoff
beta-Adrenergic receptor involvement in 6-hydroxydopamine-induced supersensitivity in rat cerebral cortex.
Science (New York, N.Y.) 1976;194(4265):624-6.
1976: B B Wolfe; T Kendall Harden; P B Molinoff
beta-adrenergic receptors in rat liver: effects of adrenalectomy.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(4):1343-7.
1976: T Kendall Harden; B B Wolfe; P B Molinoff
Binding of iodinated beta adrenergic antagonists to proteins derived from rat heart.
Molecular pharmacology 1976;12(1):1-15.
1975: T Kendall Harden; R L Klein; R R Smith; A K Thureson-Klein; M W Lowry
Serum dopamine beta-hydroxylase activity following subarachnoid hemorrhage in man.
Medical biology 1975;53(2):100-6.
1975: R L Klein; T Kendall Harden
Newly synthesized norepinephrine accumulation in the readily releasable pool of a purified adrenergic vesicle fraction.
Life sciences 1975;16(2):315-22.
1973: T Kendall Harden; R L Garrett; R L Klein
Depression of atrial contractility by peptides isolated from normal and shock plasma.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1973;144(1):56-9.