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David Harder

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Nadi T Wickramasekera; Koryn A Carver; Debebe Gebremedhin; Ramani Ramchandran; Aaron Schuett; Padmanabhan Vakeel; David R Harder
Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries.
Mallikarjuna R Pabbidi; Marija Renic; Hurtis J Tullos; David R Harder; Howard J Jacob; Julio Juncos; Luis Juncos; Jozeph Lazar; Richard J Roman
Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.
Maia Terashvili; John R Falck; M V Nostrand; P Sarkar; David R Harder
The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture.

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2013: Nadi T Wickramasekera; Koryn A Carver; Debebe Gebremedhin; Ramani Ramchandran; Aaron Schuett; Padmanabhan Vakeel; David R Harder
Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries.
Journal of applied physiology (Bethesda, Md. : 1985) 2013;114(2):252-61.
2013: Mallikarjuna R Pabbidi; Marija Renic; Hurtis J Tullos; David R Harder; Howard J Jacob; Julio Juncos; Luis Juncos; Jozeph Lazar; Richard J Roman
Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2013;304(2):H311-7.
2012: Maia Terashvili; John R Falck; M V Nostrand; P Sarkar; David R Harder
The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture.
Neuroscience 2012;223():68-76.
2012: Zeng Jin Yang; Herman Kwansa; Lee J Martin; Richard J Roman; Erin L Carter; Daina A Crafa; David R Harder; Kathleen K Kibler; Raymond C Koehler
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor.
Journal of neurochemistry 2012;121(1):168-79.
2012: Marija Renic; John R Falck; Matthew A Florence; Debebe Gebremedhin; Nashaat Z Gerges; David R Harder; Suresh N Kumar; Richard J Roman
Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures.
American journal of physiology. Heart and circulatory physiology 2012;302(6):H1285-93.
2012: XIAOGUANG LIU; Chunyuan Li; John R Falck; David R Harder; Raymond C Koehler
Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.
American journal of physiology. Heart and circulatory physiology 2012;302(5):H1075-85.
2011: David R Harder; Jayashree Narayanan; Debebe Gebremedhin
Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow.
American journal of physiology. Heart and circulatory physiology 2011;300(5):H1557-65.
2011: John D Imig; Alexis N Simpkins; Marija Renic; David R Harder
Cytochrome P450 eicosanoids and cerebral vascular function.
Expert reviews in molecular medicine 2011;13():e7.
2010: Debebe Gebremedhin; Brian Weinberger; David Lourim; David R Harder
Adenosine can mediate its actions through generation of reactive oxygen species.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(10):1777-90.
2010: Hiroto Ohata; Debebe Gebremedhin; Jayashree Narayanan; David R Harder; Raymond C Koehler
Onset of pulmonary ventilation in fetal sheep produces pial arteriolar constriction dependent on cytochrome p450 omega-hydroxylase activity.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;109(2):412-7.
2009: Raymond C Koehler; Richard J Roman; David R Harder
Astrocytes and the regulation of cerebral blood flow.
Trends in neurosciences 2009;32(3):160-9.
2009: Marija Renic; Judith A Klaus; Tomohiro Omura; Naoya Kawashima; Michihito Onishi; Noriyuki Miyata; Raymond C Koehler; David R Harder; Richard J Roman
Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(3):629-39.
2008: Kathryn M Dunn; Marija Renic; Averia K Flasch; David R Harder; John Falck; Richard J Roman
Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2008;295(6):H2455-65.
2008: Vidudala V T S Prasad; Kasem Nithipatikom; David R Harder
Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes.
Neurochemistry international 2008;53(6-8):220-9.
2008: David F Stowe; Amadou K S Camara; James S Heisner; Mohammed Aldakkak; David R Harder
Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008;27(9):1008-15.
2008: Kazuyoshi Toyama; Heike Wulff; K George Chandy; Philippe Azam; Girija Raman; Takashi Saito; Yoshimasa Fujiwara; David L Mattson; Satarupa Das; James E Melvin; Phillip F Pratt; Ossama A Hatoum; David D Gutterman; David R Harder; Hiroto Miura
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.
The Journal of clinical investigation 2008;118(9):3025-37.
2008: Maia Terashvili; Leon F Tseng; Hsiang-En Wu; Jayashree Narayanan; Lucas M Hart; John R Falck; Phillip F Pratt; David R Harder
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
The Journal of pharmacology and experimental therapeutics 2008;326(2):614-22.
2008: Drazen Zagorac; Danica Jakovcevic; Debebe Gebremedhin; David R Harder
Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(8):1431-9.
2008: Debebe Gebremedhin; Ken Yamaura; David R Harder
Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells.
American journal of physiology. Heart and circulatory physiology 2008;294(1):H107-20.
2008: Yanrong Shi; XIAOGUANG LIU; Debebe Gebremedhin; John R Falck; David R Harder; Raymond C Koehler
Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):111-25.
2007: Maia Terashvili; Hsiang-En Wu; Rachel M Moore; David R Harder; Leon F Tseng
(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat.
European journal of pharmacology 2007;571(1):1-7.
2007: David F Stowe; Amadou K S Camara; James S Heisner; Mohammed Aldakkak; David R Harder
Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H895-901.
2007: Simmy Thomas; Srigiridhar Kotamraju; Jacek Zielonka; David R Harder; Balaraman Kalyanaraman
Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response.
Free radical biology & medicine 2007;42(7):1049-61.
2007: Danica Jakovcevic; David R Harder
Role of astrocytes in matching blood flow to neuronal activity.
Current topics in developmental biology 2007;79():75-97.
2007: Meetha Medhora; Anuradha Dhanasekaran; Stephanie K Gruenloh; Laurel K Dunn; Michael Gabrilovich; John R Falck; David R Harder; Elizabeth R Jacobs; Phillip F Pratt
Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.
Prostaglandins & other lipid mediators 2007;82(1-4):19-29.
2006: Ken Yamaura; Debebe Gebremedhin; Chenyang Zhang; Jayashree Narayanan; K Hoefert; Elizabeth R Jacobs; Raymond C Koehler; David R Harder
Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+ -activated K+ channel current in cultured rat hippocampal astrocytes.
Neuroscience 2006;143(3):703-16.
2006: Maia Terashvili; Phillip F Pratt; Debebe Gebremedhin; Jayashree Narayanan; David R Harder
Reactive oxygen species cerebral autoregulation in health and disease.
Pediatric clinics of North America 2006;53(5):1029-37, xi.
2006: Lotfi Hacein-Bey; David R Harder; H T Meier; Panayiotis N Varelas; Noriyuki Miyata; Kathryn K Lauer; Joseph F Cusick; Richard J Roman
Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage.
AJNR. American journal of neuroradiology 2006;27(6):1350-4.
2006: Raymond C Koehler; Debebe Gebremedhin; David R Harder
Role of astrocytes in cerebrovascular regulation.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(1):307-17.
2006: Kazuhiko Takeuchi; Noriyuki Miyata; Marija Renic; David R Harder; Richard J Roman
Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(1):R84-9.
2005: Drazen Zagorac; Ken Yamaura; Cindy Zhang; Richard J Roman; David R Harder
The effect of superoxide anion on autoregulation of cerebral blood flow.
Stroke; a journal of cerebral circulation 2005;36(12):2589-94.
2005: Kazuhiko Takeuchi; Marija Renic; Quinn C Bohman; David R Harder; Noriyuki Miyata; Richard J Roman
Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE.
American journal of physiology. Heart and circulatory physiology 2005;289(5):H2203-11.
2005: Noriyuki Miyata; Takayuki Seki; Yu Tanaka; Tomohiro Omura; Kazuo Taniguchi; Mariko Doi; Kagumi Bandou; Shunichi Kametani; Masakazu Sato; Shigeru Okuyama; Liana Cambj-Sapunar; David R Harder; Richard J Roman
Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.
The Journal of pharmacology and experimental therapeutics 2005;314(1):77-85.
2004: David R Harder
Ca-induced Ca release: lessons regarding cell models.
American journal of physiology. Cell physiology 2004;287(5):C1165-6.
2004: Heather A Drummond; Debebe Gebremedhin; David R Harder
Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor.
Hypertension 2004;44(5):643-8.
2004: Phillip F Pratt; Meetha Medhora; David R Harder
Mechanisms regulating cerebral blood flow as therapeutic targets.
Current opinion in investigational drugs (London, England : 2000) 2004;5(9):952-6.
2004: Xinqi Peng; Chenyang Zhang; Nabil Alkayed; David R Harder; Raymond C Koehler
Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004;24(5):509-17.
2004: Ming Yu; Liana Cambj-Sapunar; Franz Kehl; Kristopher G Maier; Kazuhiko Takeuchi; Noriyuki Miyata; Tsuyoshi Ishimoto; L Manmohan Reddy; John R Falck; Debebe Gebremedhin; David R Harder; Richard J Roman
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone.
European journal of pharmacology 2004;486(3):297-306.
2003: Liana Cambj-Sapunar; Ming Yu; David R Harder; Richard J Roman
Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation 2003;34(5):1269-75.
2003: Johan Bylund; Adam G Harder; Kristopher G Maier; Richard J Roman; David R Harder
Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6.
Archives of biochemistry and biophysics 2003;412(1):34-41.
2003: Debebe Gebremedhin; Ken Yamaura; Chenyang Zhang; Johan Bylund; Raymond C Koehler; David R Harder
Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(5):1678-87.
2003: Meetha Medhora; John Daniels; Kavita Mundey; Beate Fisslthaler; Rudi Busse; Elizabeth R Jacobs; David R Harder
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H215-24.
2002: Chenyang Zhang; David R Harder
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid.
Stroke; a journal of cerebral circulation 2002;33(12):2957-64.
2002: Yanping Liu; David R Harder; Julian H Lombard
Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteries.
American journal of physiology. Heart and circulatory physiology 2002;283(6):H2276-81.
2002: Xinqi Peng; J Ricardo Carhuapoma; Anish Bhardwaj; Nabil Alkayed; John R Falck; David R Harder; Richard J Traystman; Raymond C Koehler
Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors.
American journal of physiology. Heart and circulatory physiology 2002;283(5):H2029-37.
2002: Johan Bylund; Chenyang Zhang; David R Harder
Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.
Biochemical and biophysical research communications 2002;296(3):677-84.
2002: Nabil Alkayed; Toru Goyagi; Hung-Dong Joh; Judith A Klaus; David R Harder; Richard J Traystman; Patricia D Hurn
Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack.
Stroke; a journal of cerebral circulation 2002;33(6):1677-84.
2002: Ming Yu; Cheng-Wen Sun; Kristopher G Maier; David R Harder; Richard J Roman
Mechanism of cGMP contribution to the vasodilator response to NO in rat middle cerebral arteries.
American journal of physiology. Heart and circulatory physiology 2002;282(5):H1724-31.
2002: Franz Kehl; Liana Cambj-Sapunar; Kristopher G Maier; Noriyuki Miyata; Shunishi Kametani; Hirotsugu Okamoto; Anthony G Hudetz; Marie L Schulte; Drazen Zagorac; David R Harder; Richard J Roman
20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1556-65.
2002: David R Harder; Chenyang Zhang; Debebe Gebremedhin
Astrocytes function in matching blood flow to metabolic activity.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2002;17():27-31.
2001: Kasem Nithipatikom; A J Grall; Blythe B Holmes; David R Harder; John R Falck; William B Campbell
Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid.
Analytical biochemistry 2001;298(2):327-36.
2001: William B Campbell; David R Harder
Prologue: EDHF--what is it?
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2413-6.
2000: Richard J Roman; Kristopher G Maier; Cheng-Wen Sun; David R Harder; Magdalena Alonso-Galicia
Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids.
Clinical and experimental pharmacology & physiology 2000;27(11):855-65.
2000: Anish Bhardwaj; Frances J Northington; J Ricardo Carhuapoma; J R Falck; David R Harder; Richard J Traystman; Raymond C Koehler
P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H1616-24.
2000: Debebe Gebremedhin; AR Lange; Timothy F Lowry; M R Taheri; EK Birks; Anthony G Hudetz; Jayashree Narayanan; John R Falck; Hirotsugu Okamoto; Richard J Roman; Kasem Nithipatikom; William B Campbell; David R Harder
Production of 20-HETE and its role in autoregulation of cerebral blood flow.
Circulation research 2000;87(1):60-5.
2000: Cheng-Wen Sun; John R Falck; Hirotsugu Okamoto; David R Harder; Richard J Roman
Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H339-50.
2000: David R Harder; Richard J Roman; Debebe Gebremedhin
Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes.
Acta physiologica Scandinavica 2000;168(4):543-9.
2000: Diane H Munzenmaier; David R Harder
Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release.
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1163-7.
2000: Daling Zhu; Michael Bousamra; Darryl C Zeldin; John R Falck; Mary I Townsley; David R Harder; Richard J Roman; Elizabeth R Jacobs
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L335-43.
1999: Magdalena Alonso-Galicia; Anthony G Hudetz; H Shen; David R Harder; Richard J Roman
Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.
Stroke; a journal of cerebral circulation 1999;30(12):2727-34; discussion 2734.
1999: Beate Fisslthaler; Rüdiger Popp; Ladislau Kiss; Michael Potente; David R Harder; Ingrid Fleming; Rudi Busse
Cytochrome P450 2C is an EDHF synthase in coronary arteries.
Nature 1999;401(6752):493-7.
1999: Debebe Gebremedhin; AR Lange; William B Campbell; Cecilia J Hillard; David R Harder
Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current.
The American journal of physiology 1999;276(6 Pt 2):H2085-93.
1999: Julian H Lombard; Mary Pat Kunert; Richard J Roman; John R Falck; David R Harder; William F Jackson
Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation.
The American journal of physiology 1999;276(2 Pt 2):H503-8.
1999: Cheng-Wen Sun; John R Falck; David R Harder; Richard J Roman
Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles.
Hypertension 1999;33(1 Pt 2):414-8.
1998: David R Harder; Richard J Roman; Debebe Gebremedhin; EK Birks; AR Lange
A common pathway for regulation of nutritive blood flow to the brain: arterial muscle membrane potential and cytochrome P450 metabolites.
Acta physiologica Scandinavica 1998;164(4):527-32.
1998: Cheng-Wen Sun; Magdalena Alonso-Galicia; M R Taheri; John R Falck; David R Harder; Richard J Roman
Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles.
Circulation research 1998;83(11):1069-79.
1998: Magdalena Alonso-Galicia; Cheng-Wen Sun; John R Falck; David R Harder; Richard J Roman
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries.
The American journal of physiology 1998;275(3 Pt 2):F370-8.
1998: Debebe Gebremedhin; David R Harder; Phillip F Pratt; William B Campbell
Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite.
Journal of vascular research 1998;35(4):274-84.
1998: Daling Zhu; Richard M Effros; David R Harder; Richard J Roman; Elizabeth R Jacobs
Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs.
American journal of respiratory cell and molecular biology 1998;19(1):121-8.
1998: Debebe Gebremedhin; AR Lange; Jayashree Narayanan; M R Aebly; Elizabeth R Jacobs; David R Harder
Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current.
The Journal of physiology 1998;507 ( Pt 3)():771-81.
1998: David R Harder; Nabil Alkayed; AR Lange; Debebe Gebremedhin; Richard J Roman
Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites.
Stroke; a journal of cerebral circulation 1998;29(1):229-34.
1997: David R Harder; AR Lange; Debebe Gebremedhin; EK Birks; Richard J Roman
Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue.
Journal of vascular research 1997;34(3):237-43.
1997: Nabil Alkayed; EK Birks; Jayashree Narayanan; K A Petrie; A E Kohler-Cabot; David R Harder
Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats.
Stroke; a journal of cerebral circulation 1997;28(5):1066-72.
1996: Nabil Alkayed; EK Birks; Anthony G Hudetz; Richard J Roman; L Henderson; David R Harder
Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow.
The American journal of physiology 1996;271(4 Pt 2):H1541-6.
1996: David R Harder; Jayashree Narayanan; EK Birks; J F Liard; J D Imig; Julian H Lombard; AR Lange; Richard J Roman
Identification of a putative microvascular oxygen sensor.
Circulation research 1996;79(1):54-61.
1996: Ai-Ping Zou; J T Fleming; John R Falck; Elizabeth R Jacobs; Debebe Gebremedhin; David R Harder; Richard J Roman
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity.
The American journal of physiology 1996;270(5 Pt 2):F822-32.
1996: Nabil Alkayed; Jayashree Narayanan; Debebe Gebremedhin; M Medhora; Richard J Roman; David R Harder
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes.
Stroke; a journal of cerebral circulation 1996;27(5):971-9.
1996: William B Campbell; Debebe Gebremedhin; P F Pratt; David R Harder
Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors.
Circulation research 1996;78(3):415-23.
1996: Debebe Gebremedhin; M Kaldunski; Elizabeth R Jacobs; David R Harder; Richard J Roman
Coexistence of two types of Ca(2+)-activated K+ channels in rat renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):F69-81.
1996: Ai-Ping Zou; J T Fleming; John R Falck; Elizabeth R Jacobs; Debebe Gebremedhin; David R Harder; Richard J Roman
20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):R228-37.
1996: J D Imig; Ai-Ping Zou; D E Stec; David R Harder; John R Falck; Richard J Roman
Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):R217-27.
1995: Elizabeth R Jacobs; C Cheliakine; Debebe Gebremedhin; EK Birks; P F Davies; David R Harder
Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells.
Pflügers Archiv : European journal of physiology 1995;431(1):129-31.
1995: David R Harder; William B Campbell; Richard J Roman
Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone.
Journal of vascular research 1995;32(2):79-92.
1995: David R Harder; Jayashree Narayanan; Debebe Gebremedhin; Richard J Roman
Transduction of physical force by the vascular wall Role of phospholipase C and cytochrome P450 metabolites of arachidonic acid.
Trends in cardiovascular medicine 1995;5(1):7-14.
1994: Debebe Gebremedhin; P Bonnet; Andrew S Greene; S K England; Nancy J Rusch; Julian H Lombard; David R Harder
Hypoxia increases the activity of Ca(2+)-sensitive K+ channels in cat cerebral arterial muscle cell membranes.
Pflügers Archiv : European journal of physiology 1994;428(5-6):621-30.
1994: Yanping Liu; David R Harder; Julian H Lombard
Myogenic activation of canine small renal arteries after nonchemical removal of the endothelium.
The American journal of physiology 1994;267(1 Pt 2):H302-7.
1994: P Li; Ai-Ping Zou; N J al-Kayed; Nancy J Rusch; David R Harder
Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats.
Hypertension 1994;23(6 Pt 2):914-8.
1994: David R Harder; Debebe Gebremedhin; Jayashree Narayanan; C Jefcoat; John R Falck; William B Campbell; Richard J Roman
Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels.
The American journal of physiology 1994;266(5 Pt 2):H2098-107.
1994: Jayashree Narayanan; M Imig; Richard J Roman; David R Harder
Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol.
The American journal of physiology 1994;266(5 Pt 2):H1840-5.
1993: J D Imig; John R Falck; Debebe Gebremedhin; David R Harder; Richard J Roman
Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450.
Hypertension 1993;22(3):357-64.
1993: Bettie Sue Masters; J E Clark; Linda Roman; M Nishimoto; T J McCabe; Paul R. Ortiz de Montellano; C G Plopper; Debebe Gebremedhin; Y H Ma; David R Harder
Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli.
Journal of lipid mediators 1993;6(1-3):353-60.
1993: Debebe Gebremedhin; Y H Ma; J D Imig; David R Harder; Richard J Roman
Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats.
Journal of vascular research 1993;30(1):53-60.
1993: J D Imig; Debebe Gebremedhin; David R Harder; Richard J Roman
Modulation of vascular tone in renal microcirculation by erythrocytes: role of EDRF.
The American journal of physiology 1993;264(1 Pt 2):H190-5.
1993: Y H Ma; Debebe Gebremedhin; M L Schwartzman; John R Falck; J E Clark; Bettie Sue Masters; David R Harder; Richard J Roman
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
Circulation research 1993;72(1):126-36.
1992: A al-Tinawi; Anne V Clough; David R Harder; JH Linehan; David A Rickaby; Christopher A Dawson
Distensibility of small veins of the dog lung.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(5):2158-65.
1992: David R Harder; M L Schulte; Anne V Clough; Christopher A Dawson
An angiographic method for in vivo study of arteries of the circle of Willis in small animals.
The American journal of physiology 1992;263(5 Pt 2):H1616-22.
1992: Debebe Gebremedhin; Y H Ma; John R Falck; Richard J Roman; M VanRollins; David R Harder
Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle.
The American journal of physiology 1992;263(2 Pt 2):H519-25.
1991: C A Dawson; Allen W Cowley; G B Spurr; JL Osborn; Hershel Raff; H V Forster; David R Harder; J F Liard; Julian H Lombard; William J Stekiel
Performance on multiple choice/short answer tests is not a sufficient criterion for evaluating the educational value of live animal laboratories in the teaching of physiology.
The American journal of physiology 1991;261(6 Pt 3):S34-5.
1991: A al-Tinawi; Jane A Madden; Christopher A Dawson; JH Linehan; David R Harder; David A Rickaby
Distensibility of small arteries of the dog lung.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(5):1714-22.
1991: Y H Ma; David R Harder; J E Clark; Richard J Roman
Effects of 12-HETE on isolated dog renal arcuate arteries.
The American journal of physiology 1991;261(2 Pt 2):H451-6.
1991: Katalin Kauser; J E Clark; Bettie Sue Masters; Paul R. Ortiz de Montellano; Y H Ma; David R Harder; Richard J Roman
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.
Circulation research 1991;68(4):1154-63.
1991: P Bonnet; Nancy J Rusch; David R Harder
Characterization of an outward K+ current in freshly dispersed cerebral arterial muscle cells.
Pflügers Archiv : European journal of physiology 1991;418(3):292-6.
1990: Debebe Gebremedhin; F J Fenoy; David R Harder; Richard J Roman
Enhanced vascular tone in the renal vasculature of spontaneously hypertensive rats.
Hypertension 1990;16(6):648-54.
1990: L Lougee; Carmen Hinojosa-Laborde; David R Harder; Julian H Lombard
Effect of nifedipine on endothelin induced contractions of skeletal muscle arterioles of spontaneously hypertensive rats.
Microcirculation, endothelium, and lymphatics 1990;6(4-5):355-68.
1990: Julian H Lombard; H Eskinder; Katalin Kauser; JL Osborn; David R Harder
Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure.
The American journal of physiology 1990;259(1 Pt 2):H29-33.
1990: H Eskinder; David R Harder; Julian H Lombard
Role of the vascular endothelium in regulating the response of small arteries of the dog kidney to transmural pressure elevation and reduced PO2.
Circulation research 1990;66(5):1427-35.
1990: Katalin Kauser; Gabor M Rubanyi; David R Harder
Endothelium-dependent modulation of endothelin-induced vasoconstriction and membrane depolarization in cat cerebral arteries.
The Journal of pharmacology and experimental therapeutics 1990;252(1):93-7.
1989: David R Harder; Katalin Kauser; Richard J Roman; Julian H Lombard
Mechanisms of pressure-induced myogenic activation of cerebral and renal arteries: role of the endothelium.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1989;7(4):S11-5; discussion S16.
1989: Katalin Kauser; William J Stekiel; Gabor M Rubanyi; David R Harder
Mechanism of action of EDRF on pressurized arteries: effect on K+ conductance.
Circulation research 1989;65(1):199-204.
1989: David R Harder; C Sanchez-Ferrer; Katalin Kauser; William J Stekiel; Gabor M Rubanyi
Pressure releases a transferable endothelial contractile factor in cat cerebral arteries.
Circulation research 1989;65(1):193-8.
1989: C F Sanchez-Ferrer; Richard J Roman; David R Harder
Pressure-dependent contraction of rat juxtamedullary afferent arterioles.
Circulation research 1989;64(4):790-8.
1988: David R Harder
Increased sensitivity of cat cerebral arteries to serotonin upon elevation of transmural pressure.
Pflügers Archiv : European journal of physiology 1988;411(6):698-700.
1987: David R Harder; R Gilbert; Julian H Lombard
Vascular muscle cell depolarization and activation in renal arteries on elevation of transmural pressure.
The American journal of physiology 1987;253(4 Pt 2):F778-81.