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John Harding

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Disorders

Anatomy

Crystalline Lens

Living Beings

Cattle
Rats

Phenomena

Glycosylation

Procedures

Polyacrylamide Gel Electrophoresis

Concepts & Ideas

Risk Factors

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Network (preview)

Co-Publications
Name
8
Derham, Barry
7
Bron, Anthony
7
Yan, Hong
6
Ganea, Elena
5
Hook, Darren
4
Lou, Marjorie
4
Yan, Hong
3
Sheil, Margaret
2
Truscott, Roger
1
van Boekel, Martinus
1
Willis, Antony
1
Xing, Kuiyi
1
Muchowski, Paul
1
Koretz, JF
1
Hepburne-Scott, HW

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Publications

TOP 3
Shi Qiong; Yan Hong; Li Ming-Yong; Harding John J
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats.
Zhang Shu; Chai Fei-Yan; Yan Hong; Guo Yong; Harding J J
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats.
Yan Hong; Harding John J; Xing Kuiyi; Lou Marjorie F
Revival of glutathione reductase in human cataractous and clear lens extracts by thioredoxin and thioredoxin reductase, in conjunction with alpha-crystallin or thioltransferase.

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All Publications

2009: Shi Qiong; Yan Hong; Li Ming-Yong; Harding John J
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats.
Molecular vision 2009;15():2129-38.
2008: Zhang Shu; Chai Fei-Yan; Yan Hong; Guo Yong; Harding J J
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats.
Molecular vision 2008;14():862-70.
2007: Yan Hong; Harding John J; Xing Kuiyi; Lou Marjorie F
Revival of glutathione reductase in human cataractous and clear lens extracts by thioredoxin and thioredoxin reductase, in conjunction with alpha-crystallin or thioltransferase.
Current eye research 2007;32(5):455-63.
2006: Harding John J; Ganea Elena
Protection against glycation and similar post-translational modifications of proteins.
Biochimica et biophysica acta 2006;1764(9):1436-46.
2006: Derham Barry K; Harding John J
The effect of the presence of globular proteins and elongated polymers on enzyme activity.
Biochimica et biophysica acta 2006;1764(6):1000-6.
2006: Ganea Elena; Harding John J
Glutathione-related enzymes and the eye.
Current eye research 2006;31(1):1-11.
2006: Yan Hong; Lou Marjorie F; Fernando M Rohan; Harding John J
Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts.
Molecular vision 2006;12():1153-9.
2006: Yan Hong; Harding John J
Carnosine inhibits modifications and decreased molecular chaperone activity of lens alpha-crystallin induced by ribose and fructose 6-phosphate.
Molecular vision 2006;12():205-14.
2005: Rachdan Diyaa; Lou Marjorie F; Harding John J
Glutathione reductase from human cataract lenses can be revived by reducing agents and by a molecular chaperone, alpha-crystallin.
Current eye research 2005;30(10):919-25.
2005: Yan Hong; Harding John J
Carnosine protects against the inactivation of esterase induced by glycation and a steroid.
Biochimica et biophysica acta 2005;1741(1-2):120-6.
2005: Ganea Elena; Harding John J
Trehalose and 6-aminohexanoic acid stabilize and renature glucose-6-phosphate dehydrogenase inactivated by glycation and by guanidinium hydrochloride.
Biological chemistry 2005;386(3):269-78.
2004: Rachdan Diyaa; Lou Marjorie F; Harding John J
Revival of inactive glyceraldehyde 3-phosphate dehydrogenase in human cataract lenses by reduction.
Experimental eye research 2004;79(1):105-9.
2004: Craghill Jane; Cronshaw Andrew D; Harding John J
The identification of a reaction site of glutathione mixed-disulphide formation on gammaS-crystallin in human lens.
The Biochemical journal 2004;379(Pt 3):595-600.
2003: Yan Hong; Willis Antony C; Harding John J
Gamma III-crystallin is the primary target of glycation in the bovine lens incubated under physiological conditions.
The Biochemical journal 2003;374(Pt 3):677-85.
2003: Yan Hong; Harding John J
The molecular chaperone, alpha-crystallin, protects against loss of antigenicity and activity of esterase caused by sugars, sugar phosphate and a steroid.
Biological chemistry 2003;384(8):1185-94.
2003: Yan H; Harding J J; Hui Y N; Li M Y
Decreased chaperone activity of alpha-crystallin in selenite cataract may result from selenite-induced aggregation.
Eye (London, England) 2003;17(5):637-45.
2003: Derham Barry K; Ellory J Clive; Bron Anthony J; Harding John J
The molecular chaperone alpha-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress.
European journal of biochemistry / FEBS 2003;270(12):2605-11.
2002: Derham Barry K; Harding John J
Enzyme activity after resealing within ghost erythrocyte cells, and protection by alpha-crystallin against fructose-induced inactivation.
The Biochemical journal 2002;368(Pt 3):865-74.
2002: Harding John J
Viewing molecular mechanisms of ageing through a lens.
Ageing research reviews 2002;1(3):465-79.
2002: Derham Barry K; Harding John J
Effects of modifications of alpha-crystallin on its chaperone and other properties.
The Biochemical journal 2002;364(Pt 3):711-7.
2002: Shyadehi Akbar Z; Harding John J
Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: relevance to cataract.
Biochimica et biophysica acta 2002;1587(1):31-5.
2002: Hook Darren W A; Harding John J
The effect of modification of alpha-crystallin by prednisolone-21-hemisuccinate and fructose 6-phosphate on chaperone activity.
Developments in ophthalmology 2002;35():150-60.
2001: Derham B K; van Boekel M A; Muchowski P J; Clark J I; Horwitz J; Hepburne-Scott H W; de Jong W W; Crabbe M J; Harding J J
Chaperone function of mutant versions of alpha A- and alpha B-crystallin prepared to pinpoint chaperone binding sites.
European journal of biochemistry / FEBS 2001;268(3):713-21.
2001: Harding J J
Can drugs or micronutrients prevent cataract?
Drugs & aging 2001;18(7):473-86.
2000: Ganea E; Harding J J
alpha-crystallin assists the renaturation of glyceraldehyde-3-phosphate dehydrogenase.
The Biochemical journal 2000;345 Pt 3():467-72.
2000: Bron A J; Vrensen G F; Koretz J; Maraini G; Harding J J
The ageing lens.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde 2000;214(1):86-104.
2000: Ganea E; Harding J J
alpha-crystallin protects glucose 6-phosphate dehydrogenase against inactivation by malondialdehyde.
Biochimica et biophysica acta 2000;1500(1):49-58.
1999: Harding J J; Hassett P C; Rixon K C; Bron A J; Harvey D J
Sugars including erythronic and threonic acids in human aqueous humour.
Current eye research 1999;19(2):131-6.
1999: Yan H; Harding J J
Inactivation and loss of antigenicity of esterase by sugars and a steroid.
Biochimica et biophysica acta 1999;1454(2):183-90.
1999: Derham B K; Harding J J
Alpha-crystallin as a molecular chaperone.
Progress in retinal and eye research 1999;18(4):463-509.
1999: Harding J J
Can cataract be prevented?
Eye (London, England) 1999;13 ( Pt 3b)():454-6.
1998: Harding J J; van Heyningen R
Is month of birth associated with cataract in later life?
The British journal of ophthalmology 1998;82(5):526-7.
1998: Hook D W; Harding J J
Protection of enzymes by alpha-crystallin acting as a molecular chaperone.
International journal of biological macromolecules 1998;22(3-4):295-306.
1998: Brown N A; Bron A J; Harding J J; Dewar H M
Nutrition supplements and the eye.
Eye (London, England) 1998;12 ( Pt 1)():127-33.
1998: Bron A J; Brown N A; Harding J J; Ganea E
The lens and cataract in diabetes.
International ophthalmology clinics 1998;38(2):37-67.
1997: Hook D W; Harding J J
Inactivation of glyceraldehyde 3-phosphate dehydrogenase by sugars, prednisolone-21-hemisuccinate, cyanate and other small molecules.
Biochimica et biophysica acta 1997;1362(2-3):232-42.
1997: Blakytny R; Carver J A; Harding J J; Kilby G W; Sheil M M
A spectroscopic study of glycated bovine alpha-crystallin: investigation of flexibility of the C-terminal extension, chaperone activity and evidence for diglycation.
Biochimica et biophysica acta 1997;1343(2):299-315.
1997: Derham B K; Harding J J
Effect of aging on the chaperone-like function of human alpha-crystallin assessed by three methods.
The Biochemical journal 1997;328 ( Pt 3)():763-8.
1997: Yan H; Harding J J
Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase.
The Biochemical journal 1997;328 ( Pt 2)():599-605.
1997: Derham B K; Harding J J
The effects of ageing on the chaperone-like function of rabbit alpha-crystallin, comparing three methods of assay.
Biochimica et biophysica acta 1997;1336(2):187-94.
1997: Hook D W; Harding J J
Molecular chaperones protect catalase against thermal stress.
European journal of biochemistry / FEBS 1997;247(1):380-5.
1997: Blakytny R; Harding J J
Bovine and human alpha-crystallins as molecular chaperones: prevention of the inactivation of glutathione reductase by fructation.
Experimental eye research 1997;64(6):1051-8.
1997: Kilby G W; Sheil M M; Shaw D; Harding J J; Truscott R J
Amino acid sequence of bovine gamma E (IVa) lens crystallin.
Protein science : a publication of the Protein Society 1997;6(4):909-12.
1996: Harding J J; Blakytny R; Ganea E
Glutathione in disease.
Biochemical Society transactions 1996;24(3):881-4.
1996: Ganea E; Harding J J
Inhibition of 6-phosphogluconate dehydrogenase by carbamylation and protection by alpha-crystallin, a chaperone-like protein.
Biochemical and biophysical research communications 1996;222(2):626-31.
1996: Heath M M; Rixon K C; Harding J J
Glycation-induced inactivation of malate dehydrogenase protection by aspirin and a lens molecular chaperone, alpha-crystallin.
Biochimica et biophysica acta 1996;1315(3):176-84.
1996: Hook D W; Harding J J
Alpha-crystallin acting as a molecular chaperone protects catalase against steroid-induced inactivation.
FEBS letters 1996;382(3):281-4.
1996: Hsuan J D; Harding J J; Bron A J
The penetration of topical cysteamine into the human eye.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1996;12(4):499-502.
1996: Riley M L; Harding J J; Kilby G W; Truscott R J; Aquilina A; Sheil M M
Molecular masses of gamma-crystallins.
Ophthalmic research 1996;28 Suppl 2():131-5.
1996: Ganea E; Harding J J
Lens proteins changes induced by sugars and pyridoxal phosphate.
Ophthalmic research 1996;28 Suppl 1():65-8.
1996: Blakytny R; Harding J J
Prevention of the fructation-induced inactivation of glutathione reductase by bovine alpha-crystallin acting as a molecular chaperone.
Ophthalmic research 1996;28 Suppl 1():19-22.
1995: Blakytny R; Harding J J
Prevention of the inactivation of glutathione reductase by fructation using human alpha-crystallin.
Biochemical Society transactions 1995;23(4):610S.
1995: Ganea E; Harding J J
Molecular chaperones protect against glycation-induced inactivation of glucose-6-phosphate dehydrogenase.
European journal of biochemistry / FEBS 1995;231(1):181-5.
1995: Riley M L; Harding J J
The reaction of methylglyoxal with human and bovine lens proteins.
Biochimica et biophysica acta 1995;1270(1):36-43.
1995: Harding J J
Common pathways in lens research.
Ophthalmic research 1995;27 Suppl 1():18-9.
1994: Ganea E; Harding J J
Inactivation of glucose-6-phosphate dehydrogenase by glycation.
Biochemical Society transactions 1994;22(4):445S.
1994: Ganea E; Rixon K C; Harding J J
Binding of glucose, galactose and pyridoxal phosphate to lens crystallins.
Biochimica et biophysica acta 1994;1226(3):286-90.
1994: Pennington J; Harding J J
Identification of the site of glycation of gamma-II-crystallin by (14C)-fructose.
Biochimica et biophysica acta 1994;1226(2):163-7.
1994: Lewis B S; Harding J J; Quinlan M; Bron A J
Lenses with retrodots do not have a high oxalate content.
Developments in ophthalmology 1994;26():87-9.
1994: Harding J J; Egerton M
Diabetes, sex, and cataract.
Developments in ophthalmology 1994;26():11-3.
1993: Riley M L; Harding J J
The reaction of malondialdehyde with lens proteins and the protective effect of aspirin.
Biochimica et biophysica acta 1993;1158(2):107-12.
1993: Harding J J; Egerton M; van Heyningen R; Harding R S
Diabetes, glaucoma, sex, and cataract: analysis of combined data from two case control studies.
The British journal of ophthalmology 1993;77(1):2-6.
1993: Bron A J; Sparrow J; Brown N A; Harding J J; Blakytny R
The lens in diabetes.
Eye (London, England) 1993;7 ( Pt 2)():260-75.
1992: Blakytny R; Harding J J
Glycation (non-enzymic glycosylation) inactivates glutathione reductase.
The Biochemical journal 1992;288 ( Pt 1)():303-7.
1992: Shyadehi A Z; Harding J J
Attempts to provide an insight into the anti-cataract effect of ibuprofen.
Biochemical Society transactions 1992;20(2):210S.
1992: Blakytny R; Harding J J
Prevention of cataract in diabetic rats by aspirin, paracetamol (acetaminophen) and ibuprofen.
Experimental eye research 1992;54(4):509-18.
1991: Shyadehi A Z; Harding J J
Investigations of ibuprofen and paracetamol binding to lens proteins to explore their protective role against cataract.
Biochemical pharmacology 1991;42(11):2077-84.
1991: Raza K; Harding J J
Non-enzymic modification of lens proteins by glucose and fructose: effects of ibuprofen.
Experimental eye research 1991;52(2):205-12.
1991: Harding J J
Post-translational modification of lens proteins in cataract.
Lens and eye toxicity research 1991;8(2-3):245-50.
1990: Lewis B S; Harding J J
The effects of aminoguanidine on the glycation (non-enzymic glycosylation) of lens proteins.
Experimental eye research 1990;50(5):463-7.
1990: Roberts K A; Harding J J
Ibuprofen, a putative anti-cataract drug, protects the lens against cyanate and galactose.
Experimental eye research 1990;50(2):157-64.
1989: Harding J J; Beswick H T; Ajiboye R; Huby R; Blakytny R; Rixon K C
Non-enzymic post-translational modification of proteins in aging. A review.
Mechanisms of ageing and development 1989;50(1):7-16.
1989: Harding J J; Egerton M; Harding R S
Protection against cataract by aspirin, paracetamol and ibuprofen.
Acta ophthalmologica 1989;67(5):518-24.
1989: Harding J J; Harding R S; Egerton M
Risk factors for cataract in Oxfordshire: diabetes, peripheral neuropathy, myopia, glaucoma and diarrhoea.
Acta ophthalmologica 1989;67(5):510-7.
1989: Martin S; Harding J J
Site of carbamoylation of bovine gamma-II-crystallin by potassium [14C]cyanate.
The Biochemical journal 1989;262(3):909-15.
1989: Ajiboye R; Harding J J
The non-enzymic glycosylation of bovine lens proteins by glucosamine and its inhibition by aspirin, ibuprofen and glutathione.
Experimental eye research 1989;49(1):31-41.
1989: Ibrahim J; Harding J J
Pinpointing the sites of hydroxylysine glycosides in peptide alpha 1-CB7 of bovine corneal collagen, and their possible role in determining fibril diameter and thus transparency.
Biochimica et biophysica acta 1989;992(1):9-22.
1989: Harding J J; van Heyningen R
Beer, cigarettes and military work as risk factors for cataract.
Developments in ophthalmology 1989;17():13-6.
1988: Harding J J; van Heyningen R
Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide.
The British journal of ophthalmology 1988;72(11):809-14.
1988: van Heyningen R; Harding J J
A case-control study of cataract in Oxfordshire: some risk factors.
The British journal of ophthalmology 1988;72(11):804-8.
1988: Lewis B S; Harding J J
The major metabolite of bendazac inhibits the glycosylation of soluble lens proteins: a possible mechanism for a delay in cataractogenesis.
Experimental eye research 1988;47(2):217-25.
1988: Huby R; Harding J J
Non-enzymic glycosylation (glycation) of lens proteins by galactose and protection by aspirin and reduced glutathione.
Experimental eye research 1988;47(1):53-9.
1988: Harding J J; Beswick H T
The possible contribution of glucose autoxidation to protein modification of diabetes.
The Biochemical journal 1988;249(2):617-8.
1987: Beswick H T; Harding J J
High-molecular-weight crystallin aggregate formation resulting from non-enzymic carbamylation of lens crystallins: relevance to cataract formation.
Experimental eye research 1987;45(4):569-78.
1987: Beswick H T; Harding J J
Conformational changes induced in lens alpha- and gamma-crystallins by modification with glucose 6-phosphate. Implications for cataract.
The Biochemical journal 1987;246(3):761-9.
1987: Harding J J; van Heyningen R
Case-control study of cataract in Oxford.
Developments in ophthalmology 1987;15():99-103.
1987: Harding J J; van Heyningen R
Epidemiology and risk factors for cataract.
Eye (London, England) 1987;1 ( Pt 5)():537-41.
1986: Lewis B S; Rixon K C; Harding J J
Bendazac prevents cyanate binding to soluble lens proteins and cyanate-induced phase-separation opacities in vitro: a possible mechanism by which bendazac could delay cataract.
Experimental eye research 1986;43(6):973-9.
1986: Harding J J; van Heyningen R
Aspirin-like analgesics and cataract.
Lancet 1986;2(8514):1044-5.
1986: van Heyningen R; Harding J J
Aspirin-like analgesics and cataract.
Lancet 1986;2(8501):283.
1986: van Heyningen R; Harding J J
Do aspirin-like analgesics protect against cataract? A case-control study.
Lancet 1986;1(8490):1111-3.
1985: Harding J J; Beswick H T
Modification of DNA and protein in cataract.
Experimental eye research 1985;40(3):497-8.
1985: Beswick H T; Harding J J
Aldehydes or dicarbonyls in non-enzymic glycosylation of proteins.
The Biochemical journal 1985;226(2):385-9.
1985: Harding J J; Rixon K C
Lens opacities induced in rat lenses by methyl isocyanate.
Lancet 1985;1(8431):762.
1985: Crompton M; Rixon K C; Harding J J
Aspirin prevents carbamylation of soluble lens proteins and prevents cyanate-induced phase separation opacities in vitro: a possible mechanism by which aspirin could prevent cataract.
Experimental eye research 1985;40(2):297-311.
1984: Beswick H T; Harding J J
Conformational changes induced in bovine lens alpha-crystallin by carbamylation. Relevance to cataract.
The Biochemical journal 1984;223(1):221-7.
1981: Harding J J; Rixon K C
Is diarrhoea a major cause of cataract in some tropical countries?
Metabolic and pediatric ophthalmology 1981;5(3-4):161-6.
1980: Harding J J; Rixon K C
Carbamylation of lens proteins: a possible factor in cataractogenesis in some tropical countries.
Experimental eye research 1980;31(5):567-71.

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