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Giles Hardingham

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TOP 3
Kunal Gupta; Giles E Hardingham; Siddharthan Chandran
NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.
Kunal Gupta; Siddharthan Chandran; Giles E Hardingham
Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.
Francesc X Soriano; Paul Skehel; Sangeeta Chawla; Giles E Hardingham
SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites.

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All Publications

2013: Kunal Gupta; Giles E Hardingham; Siddharthan Chandran
NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.
Neuroscience letters 2013;543():95-100.
2013: Kunal Gupta; Siddharthan Chandran; Giles E Hardingham
Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.
British journal of clinical pharmacology 2013;75(4):907-18.
2013: Francesc X Soriano; Paul Skehel; Sangeeta Chawla; Giles E Hardingham
SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites.
Journal of neurochemistry 2013;124(1):26-35.
2012: S Edman; Giles E Hardingham; M R Livesey; L J Macdonald; S McKay; M Samadi; David J A Wyllie
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Neuropharmacology 2012;63(3):441-9.
2012: Rickie Patani; Clare A Puddifoot; Siddharthan Chandran; Giles E Hardingham; John Hardy; Patrick A Lewis; Colin Smith; Daniah Trabzuni; Robert Walker; Michael Weale; David J A Wyllie; Mina Ryten
Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.
Journal of neurochemistry 2012;122(4):738-51.
2012: Clare Puddifoot; Francesc X Soriano; antonio vidal-puig; David J A Wyllie; Alberto Camacho; Marc-Andre Martel; Giles E Hardingham
PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(20):6995-7000.
2012: Marc-André Martel; Aoife McMahon; Tomas John Ryan; David J A Wyllie; Bashayer Al-Mubarak; Karen F S Bell; Jill H Fowler; Seth G N Grant; Karen Horsburgh; Peter Cornell Kind; Noboru H Komiyama; Giles E Hardingham
The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.
Neuron 2012;74(3):543-56.
2012: K Gupta; Giles E Hardingham; John D Hayes; R Patani; R A Pedersen; A Serio; D Story; T Tsujita; P Baxter; Siddharthan Chandran
Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.
Cell death and differentiation 2012;19(5):779-87.
2012: Bilada Bilican; Monica Carrasco; Sami J Barmada; George Q Daley; Steven Finkbeiner; Judy Fletcher; Brad A Friedman; Giles E Hardingham; Tom Maniatis; Agnes Lumi Nishimura; In-Hyun Park; Hemali P Phatnani; Clare A Puddifoot; Andrea Serio; Christopher E Shaw; David Story; Gareth J Sullivan; Ian Wilmut; David J A Wyllie; Siddharthan Chandran
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(15):5803-8.
2012: A C McMahon; T S O'Leary; Sofia Papadia; P N Stoney; David J A Wyllie; Mark W Barnett; Jyoti S Choudhary; Mark Collins; S G N Grant; Giles E Hardingham; Noboru H Komiyama; Peter Cornell Kind
SynGAP isoforms exert opposing effects on synaptic strength.
Nature communications 2012;3():900.
2011: Paul S Baxter; Peter Cornell Kind; Marc-Andre Martel; Aoife McMahon; Giles E Hardingham
Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.
Journal of neurochemistry 2011;118(3):365-78.
2011: Giles E Hardingham; Stuart A Lipton
Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes.
Antioxidants & redox signaling 2011;14(8):1421-4.
2011: Karen F S Bell; Giles E Hardingham
CNS peroxiredoxins and their regulation in health and disease.
Antioxidants & redox signaling 2011;14(8):1467-77.
2011: Francesc X Soriano; Frédéric Léveillé; Sofia Papadia; Karen F S Bell; Clare Puddifoot; Giles E Hardingham
Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses.
Antioxidants & redox signaling 2011;14(8):1425-36.
2011: Karen F S Bell; Giles E Hardingham
The influence of synaptic activity on neuronal health.
Current opinion in neurobiology 2011;21(2):299-305.
2011: Karen F Bell; Bashayer Al-Mubarak; Jill H Fowler; Paul S Baxter; Kunal Gupta; Tadayuki Tsujita; Sudhir Chowdhry; Rickie Patani; Siddharthan Chandran; Karen Horsburgh; John D Hayes; Giles E Hardingham
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):E1-2; author reply E3-4.
2011: Karen F S Bell; Jill H Fowler; Bashayer Al-Mubarak; Karen Horsburgh; Giles E Hardingham
Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning.
Oxidative medicine and cellular longevity 2011;2011():689524.
2011: Francesc X Soriano; Giles E Hardingham
In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export.
PloS one 2011;6(6):e21056.
2011: R Patani; A J Hollins; T M Wishart; C A Puddifoot; S Alvarez; A R de Lera; David J A Wyllie; D A S Compston; Roger A Pedersen; T H Gillingwater; Giles E Hardingham; Nicholas D Allen; Siddharthan Chandran
Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.
Nature communications 2011;2():214.
2010: Giles E Hardingham; Hilmar Bading
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.
Nature reviews. Neuroscience 2010;11(10):682-96.
2010: Michael Fricker; Sofia Papadia; Giles E Hardingham; Aviva M Tolkovsky
Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons.
Journal of neurochemistry 2010;114(3):772-83.
2010: Giles E Hardingham; Rickie Patani; Paul Baxter; David J Wyllie; Siddharthan Chandran
Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.
Molecular neurobiology 2010;42(1):97-102.
2010: Frédéric Léveillé; Sofia Papadia; Michael Fricker; Karen F S Bell; Francesc X Soriano; Marc-André Martel; Clare Puddifoot; Marlen Habel; David J A Wyllie; Chrysanthy Ikonomidou; Aviva M Tolkovsky; Giles E Hardingham
Suppression of the intrinsic apoptosis pathway by synaptic activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(7):2623-35.
2009: Giles E Hardingham
Coupling of the NMDA receptor to neuroprotective and neurodestructive events.
Biochemical Society transactions 2009;37(Pt 6):1147-60.
2009: Bashayer Al-Mubarak; Francesc X Soriano; Giles E Hardingham
Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene.
Channels (Austin, Tex.) 2009;3(4):233-8.
2009: Frédéric Léveillé; Francesc X Soriano; Sofia Papadia; Giles E Hardingham
Excitotoxic insults lead to peroxiredoxin hyperoxidation.
Oxidative medicine and cellular longevity 2009;2(2):110-3.
2009: Francesc X Soriano; Sofia Papadia; Karen F S Bell; Giles E Hardingham
Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2.
Epigenetics : official journal of the DNA Methylation Society 2009;4(3):152-8.
2009: Francesc X Soriano; Paul Baxter; Lyndsay M Murray; Michael B. Sporn; Thomas H Gillingwater; Giles E Hardingham
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin.
Molecules and cells 2009;27(3):279-82.
2009: M-A Martel; David J A Wyllie; Giles E Hardingham
In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death.
Neuroscience 2009;158(1):334-43.
2009: Rickie Patani; Alastair Compston; Clare A Puddifoot; David J A Wyllie; Giles E Hardingham; Nicholas D Allen; Siddharthan Chandran
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.
PloS one 2009;4(10):e7327.
2009: Marc-Andre Martel; Francesc X Soriano; Paul Baxter; Colin Rickman; Rory Duncan; David J A Wyllie; Giles E Hardingham
Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.
Channels (Austin, Tex.) 2009;3(1):12-5.
2008: L Ramage; M-A Martel; Giles E Hardingham; Donald Salter
NMDA receptor expression and activity in osteoarthritic human articular chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(12):1576-84.
2008: Francesc X Soriano; Marc-Andre Martel; Sofia Papadia; Anne Vaslin; Paul Baxter; Colin Rickman; Joan Forder; Michael Tymianski; Rory Duncan; Michelle Aarts; Peter Clarke; David J A Wyllie; Giles E Hardingham
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(42):10696-710.
2008: Francesc X Soriano; Frédéric Léveillé; Sofia Papadia; Larry G Higgins; James Varley; Paul Baxter; John D Hayes; Giles E Hardingham
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.
Journal of neurochemistry 2008;107(2):533-43.
2008: Sofia Papadia; Francesc X Soriano; Frédéric Léveillé; Marc-Andre Martel; Kelly A Dakin; Henrik H Hansen; Angela Kaindl; Marco Sifringer; Jill Fowler; Vanya Stefovska; Grahame McKenzie; Marie Craigon; Roderick Corriveau; Peter Ghazal; Karen Horsburgh; Bruce A Yankner; David J A Wyllie; Chrysanthy Ikonomidou; Giles E Hardingham
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.
Nature neuroscience 2008;11(4):476-87.
2007: Sofia Papadia; Giles E Hardingham
The dichotomy of NMDA receptor signaling.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2007;13(6):572-9.
2007: Francesc X Soriano; Giles E Hardingham
Compartmentalized NMDA receptor signalling to survival and death.
The Journal of physiology 2007;584(Pt 2):381-7.
2007: Neil R Hardingham; Giles E Hardingham; Kevin D Fox; Julian J B Jack
Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity.
Journal of neurophysiology 2007;97(4):2965-75.
2006: Giles E Hardingham
Pro-survival signalling from the NMDA receptor.
Biochemical Society transactions 2006;34(Pt 5):936-8.
2006: Neil R Hardingham; Neil J Bannister; Jenny Read; Kevin D Fox; Giles E Hardingham; Julian J B Jack
Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(23):6337-45.
2006: Giles E Hardingham
2B synaptic or extrasynaptic determines signalling from the NMDA receptor.
The Journal of physiology 2006;572(Pt 3):614-5.
2006: Francesc X Soriano; Sofia Papadia; Frank Hofmann; Neil R Hardingham; Hilmar Bading; Giles E Hardingham
Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4509-18.
2006: Grahame J Mckenzie; George A Ward; Yvette Stallwood; Emmanuel Briend; Sofia Papadia; Andrew Lennard; Martin Turner; Brian R Champion; Giles E Hardingham
Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals.
BMC cell biology 2006;7():10.
2005: Sofia Papadia; Patrick Stevenson; Neil R Hardingham; Hilmar Bading; Giles E Hardingham
Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(17):4279-87.
2005: Grahame J Mckenzie; Patrick Stevenson; George A Ward; Sofia Papadia; Hilmar Bading; Sangeeta Chawla; Martin L Privalsky; Giles E Hardingham
Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.
Journal of neurochemistry 2005;93(1):171-85.
2003: Anna Pokorska; Peter Vanhoutte; Fiona J L Arnold; Francesca Silvagno; Giles E Hardingham; Hilmar Bading
Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons.
Journal of neurochemistry 2003;84(3):447-52.
2003: Giles E Hardingham; Hilmar Bading
The Yin and Yang of NMDA receptor signalling.
Trends in neurosciences 2003;26(2):81-9.
2002: Giles E Hardingham; Hilmar Bading
Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated.
Biochimica et biophysica acta 2002;1600(1-2):148-53.
2002: Giles E Hardingham; Y Fukunaga; Hilmar Bading
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.
Nature neuroscience 2002;5(5):405-14.
2001: Giles E Hardingham; Fiona J L Arnold; Hilmar Bading
A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication.
Nature neuroscience 2001;4(6):565-6.
2001: Giles E Hardingham; Fiona J L Arnold; Hilmar Bading
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.
Nature neuroscience 2001;4(3):261-7.
1999: Giles E Hardingham; Hilmar Bading
Calcium as a versatile second messenger in the control of gene expression.
Microscopy research and technique 1999;46(6):348-55.
1999: Giles E Hardingham; Sangeeta Chawla; FH Cruzalegui; Hilmar Bading
Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels.
Neuron 1999;22(4):789-98.
1999: FH Cruzalegui; Giles E Hardingham; Hilmar Bading
c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation.
The EMBO journal 1999;18(5):1335-44.
1998: Giles E Hardingham; Hilmar Bading
Nuclear calcium: a key regulator of gene expression.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1998;11(4):345-58.
1998: Sangeeta Chawla; Giles E Hardingham; D R Quinn; Hilmar Bading
CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.
Science (New York, N.Y.) 1998;281(5382):1505-9.
1998: Giles E Hardingham; FH Cruzalegui; Sangeeta Chawla; Hilmar Bading
Mechanisms controlling gene expression by nuclear calcium signals.
Cell calcium 1998;23(2-3):131-4.
1997: Hilmar Bading; Giles E Hardingham; Christopher M Johnson; Sangeeta Chawla
Gene regulation by nuclear and cytoplasmic calcium signals.
Biochemical and biophysical research communications 1997;236(3):541-3.
1997: Giles E Hardingham; Sangeeta Chawla; Christopher M Johnson; Hilmar Bading
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression.
Nature 1997;385(6613):260-5.