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Joel Hardink

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Manisha Shah; Mark Waltham; Tony Blick; Andrea Connor; Joel R Hardink; Dexing Huang; Conor C Lynch; Lawrence A Reiter; Erik W Thompson
An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer.
Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Lawrence A Reiter; Kevin D Freeman-Cook; Christopher S Jones; Gary J Martinelli; Amy S Antipas; Martin A Berliner; Kaushik Datta; James T Downs; James D Eskra; Michael D Forman; Elaine M Greer; Roberto Guzman; Joel R Hardink; Fouad Janat; Nandell F Keene; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Donald Robertson; Diana Sperger; Marcie L Vaughn-Bowser; Darra M Waller; Sue A Yocum
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

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All Publications

2012: Manisha Shah; Mark Waltham; Tony Blick; Andrea Connor; Joel R Hardink; Dexing Huang; Conor C Lynch; Lawrence A Reiter; Erik W Thompson
An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer.
PloS one 2012;7(1):e29615.
2007: Kevin D Freeman-Cook; Lawrence A Reiter; Mark C Noe; Amy S Antipas; dennis danley; Kaushik Datta; James T Downs; Shane Eisenbeis; James D Eskra; David J Garmene; Elaine M Greer; Richard J Griffiths; Roberto Guzman; Joel R Hardink; Fouad Janat; Christopher S Jones; Gary J Martinelli; Peter G Mitchell; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Jayvardhan Pandit; Usa D Reilly; Donald Robertson; Marcie L Vaughn-Bowser; Lilli A Wolf-Gouviea; Sue A Yocum
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2007;17(23):6529-34.
2006: Lawrence A Reiter; Kevin D Freeman-Cook; Christopher S Jones; Gary J Martinelli; Amy S Antipas; Martin A Berliner; Kaushik Datta; James T Downs; James D Eskra; Michael D Forman; Elaine M Greer; Roberto Guzman; Joel R Hardink; Fouad Janat; Nandell F Keene; Ellen R Laird; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Donald Robertson; Diana Sperger; Marcie L Vaughn-Bowser; Darra M Waller; Sue A Yocum
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Bioorganic & medicinal chemistry letters 2006;16(22):5822-6.
2005: Mark C Noe; Vijayalakshmi Natarajan; Sheri L Snow; Peter G Mitchell; Lori L Lopresti-Morrow; Lisa M Reeves; Sue A Yocum; Thomas J Carty; John A Barberia; Francis J Sweeney; Jennifer L Liras; Marcie Vaughn; Joel R Hardink; Joel M Hawkins; Christopher Tokar
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.
Bioorganic & medicinal chemistry letters 2005;15(11):2808-11.
2005: Julian A Blagg; Mark C Noe; Lilli A Wolf-Gouveia; Lawrence A Reiter; Ellen R Laird; Shang-Poa P Chang; dennis danley; James T Downs; Nancy C Elliott; James D Eskra; Richard J Griffiths; Joel R Hardink; Amber I Haugeto; Christopher S Jones; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Jayvardhan Pandit; Ralph P Robinson; Chakrapani Subramanyam; Marcie L Vaughn-Bowser; Sue A Yocum
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Bioorganic & medicinal chemistry letters 2005;15(7):1807-10.
2003: Michael A Letavic; John T Barberia; Thomas J Carty; Joel R Hardink; Jennifer L Liras; Lori L Lopresti-Morrow; Peter G Mitchell; Mark C Noe; Lisa M Reeves; Sheri L Snow; Ethan J Stam; Francis J Sweeney; Marcie Vaughn; Chul H Yu
Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(19):3243-6.