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Anne Harduin-Lepers

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Chemicals & Drugs

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Cloning, Molecular

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Glycosylation

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Breast Neoplasms

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Sylvie Juliant; Marylêne Lévêque; Annick Ozil; Marie-Christine Slomianny; Marie-Luce Violet; Pierre Cérutti; Sylvie Choblet; Anne Harduin-Lepers; Martine Cérutti
Engineering the baculovirus genome to produce galactosylated antibodies in lepidopteran cells.
Florent Colomb; Philippe Delannoy; Fala El Machhour; Anne Harduin-Lepers; Sophie Jaillard; Marie-Ange Krzewinski-Recchi; Jean-Jacques Lafitte; Eric Mensier; Agata Steenackers; Sophie Groux-Degroote
TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX.
Jorick Vanbeselaere; Nao Yamakawa; Anne Harduin-Lepers; Kay-Hooi Khoo; Christian Slomianny; Christophe Biot; Lan-Yi Chang; Emeline Fabre; Yann Guerardel
Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies.

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All Publications

2013: Sylvie Juliant; Marylêne Lévêque; Annick Ozil; Marie-Christine Slomianny; Marie-Luce Violet; Pierre Cérutti; Sylvie Choblet; Anne Harduin-Lepers; Martine Cérutti
Engineering the baculovirus genome to produce galactosylated antibodies in lepidopteran cells.
Methods in molecular biology (Clifton, N.J.) 2013;988():59-77.
2012: Florent Colomb; Philippe Delannoy; Fala El Machhour; Anne Harduin-Lepers; Sophie Jaillard; Marie-Ange Krzewinski-Recchi; Jean-Jacques Lafitte; Eric Mensier; Agata Steenackers; Sophie Groux-Degroote
TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX.
Biochimie 2012;94(9):2045-53.
2012: Jorick Vanbeselaere; Nao Yamakawa; Anne Harduin-Lepers; Kay-Hooi Khoo; Christian Slomianny; Christophe Biot; Lan-Yi Chang; Emeline Fabre; Yann Guerardel
Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies.
Journal of proteome research 2012;11(4):2164-77.
2012: Yann Guérardel; Anne Harduin-Lepers; Lan-Yi Chang; Bernadette Coddeville; Akiko Fujita; Kaoru Kubokawa; Emmanuel Maes; Chihiro Sato; Ken Kitajima
Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution.
Glycobiology 2012;22(4):479-91.
2011: Magali Audry; Charlotte Jeanneau; Anne Imberty; Anne Harduin-Lepers; Philippe Delannoy; Christelle Breton
Current trends in the structure-activity relationships of sialyltransferases.
Glycobiology 2011;21(6):716-26.
2011: Béatrice Teylaert; Edwige Meurice; Marie Bobowski; Anne Harduin-Lepers; Christine Gaucher; alexandre fontayne; Sylvie Jorieux; Philippe Delannoy
Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0.
BMC biotechnology 2011;11():1.
2010: Daniel Petit; Anne-Marie Mir; Jean-Michel Petit; Christine Thisse; Philippe Delannoy; Rafael Oriol; Bernard Thisse; Anne Harduin-Lepers
Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes.
The Journal of biological chemistry 2010;285(49):38399-414.
2010: Aurélie Cazet; Sylvain Julien; Marie Bobowski; Marie-Ange Krzewinski-Recchi; Anne Harduin-Lepers; Sophie Groux-Degroote; Philippe Delannoy
Consequences of the expression of sialylated antigens in breast cancer.
Carbohydrate research 2010;345(10):1377-83.
2010: A S Carvalho; Anne Harduin-Lepers; A Magalhães; E Machado; Nuno Mendes; L T Costa; R Matthiesen; Raquel Almeida; J Costa; Celso A Reis
Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.
The international journal of biochemistry & cell biology 2010;42(1):80-9.
2009: Lan-Yi Chang; Anne Harduin-Lepers; Ken Kitajima; Chihiro Sato; Chang-Jen Huang; Kay-Hooi Khoo; Yann Guérardel
Developmental regulation of oligosialylation in zebrafish.
Glycoconjugate journal 2009;26(3):247-61.
2009: Lan-Yi Chang; Anne-Marie Mir; Christine Thisse; Yann Guérardel; Philippe Delannoy; Bernard Thisse; Anne Harduin-Lepers
Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system.
Glycoconjugate journal 2009;26(3):263-75.
2008: Céline Guinez; Anne-Marie Mir; Vanessa Dehennaut; René Cacan; Anne Harduin-Lepers; Jean-Claude Michalski; Tony Lefebvre
Protein ubiquitination is modulated by O-GlcNAc glycosylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2901-11.
2008: Anne Harduin-Lepers; Daniel Petit; Rosella Mollicone; Philippe Delannoy; Jean-Michel Petit; Rafael Oriol
Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes.
BMC evolutionary biology 2008;8():258.
2007: Sandra Pinho; Nuno T Marcos; Bibiana Ferreira; Ana S Carvalho; Maria José Oliveira; Filipe Santos-Silva; Anne Harduin-Lepers; Celso A Reis
Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.
Cancer letters 2007;249(2):157-70.
2006: Philippe F Rohfritsch; John A F Joosten; Marie-Ange Krzewinski-Recchi; Anne Harduin-Lepers; Benoit Laporte; Sylvie Juliant; Martine Cerutti; Philippe Delannoy; Johannes Vliegenthart; Johannis P Kamerling
Probing the substrate specificity of four different sialyltransferases using synthetic beta-D-Galp-(1-->4)-beta-D-GlcpNAc-(1-->2)-alpha-D-Manp-(1-->O) (CH(2))7CH3 analogues general activating effect of replacing N-acetylglucosamine by N-propionylglucosamine.
Biochimica et biophysica acta 2006;1760(4):685-92.
2005: Mélanie Teintenier-Lelièvre; sylvain julien; Sylvie Juliant; Yann Guerardel; Martine Duonor-Cérutti; Philippe Delannoy; Anne Harduin-Lepers
Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins.
The Biochemical journal 2005;392(Pt 3):665-74.
2005: Anne Harduin-Lepers; Rosella Mollicone; Philippe Delannoy; Rafael Oriol
The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.
Glycobiology 2005;15(8):805-17.
2004: Nuno T Marcos; Sandra Pinho; Catarina Grandela; Andrea Cruz; Bénédicte Samyn-Petit; Anne Harduin-Lepers; Raquel Almeida; Filipe Silva; Vanessa Morais; Julia Costa; Jan Kihlberg; Henrik Clausen; Celso A Reis
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
Cancer research 2004;64(19):7050-7.
2004: Charlotte Jeanneau; Valérie Chazalet; Claudine Augé; Dikeos Soumpasis; Anne Harduin-Lepers; Philippe Delannoy; Anne Imberty; Christelle Breton
Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif.
The Journal of biological chemistry 2004;279(14):13461-8.
2003: Maria-Dolores Montiel; Marie-Ange Krzewinski-Recchi; Philippe Delannoy; Anne Harduin-Lepers
Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.
The Biochemical journal 2003;373(Pt 2):369-79.
2003: Tatiana Ivannikova; Fabrice Bintein; Annie Malleron; Sylvie Juliant; Martine Cerutti; Anne Harduin-Lepers; Philippe Delannoy; Claudine Augé; André Lubineau
Recombinant (2-->3)-alpha-sialyltransferase immobilized on nickel-agarose for preparative synthesis of sialyl Lewis(x) and Lewis(a) precursor oligosaccharides.
Carbohydrate research 2003;338(11):1153-61.
2003: Mohamed Hebbar; Marie-Ange Krzewinski-Recchi; Louis Hornez; Alain Verdière; Anne Harduin-Lepers; Jacques Bonneterre; Philippe Delannoy; Jean-Philippe Peyrat
Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients.
The International journal of biological markers 2003;18(2):116-22.
2003: Marie-Ange Krzewinski-Recchi; sylvain julien; Sylvie Juliant; Mélanie Teintenier-Lelièvre; Bénédicte Samyn-Petit; Maria-Dolores Montiel; Anne-Marie Mir; Martine Cerutti; Anne Harduin-Lepers; Philippe Delannoy
Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.
European journal of biochemistry / FEBS 2003;270(5):950-61.
2002: François Foulquier; Anne Harduin-Lepers; Sandrine Duvet; Ingrid Marchal; Anne-Marie Mir; Philippe Delannoy; Frédéric Chirat; René Cacan
The unfolded protein response in a dolichyl phosphate mannose-deficient Chinese hamster ovary cell line points out the key role of a demannosylation step in the quality-control mechanism of N-glycoproteins.
The Biochemical journal 2002;362(Pt 2):491-8.
2001: sylvain julien; Marie-Ange Krzewinski-Recchi; Anne Harduin-Lepers; Valérie Gouyer; Guillemette Huet; Xuefen Le Bourhis; Philippe Delannoy
Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.
Glycoconjugate journal 2001;18(11-12):883-93.
2001: V Vallejo-Ruiz; R Haque; Anne-Marie Mir; Tilo Schwientek; Ulla Mandel; René Cacan; Philippe Delannoy; Anne Harduin-Lepers
Delineation of the minimal catalytic domain of human Galbeta1-3GalNAc alpha2,3-sialyltransferase (hST3Gal I).
Biochimica et biophysica acta 2001;1549(2):161-73.
2001: Anne Harduin-Lepers; V Vallejo-Ruiz; Marie-Ange Krzewinski-Recchi; Bénédicte Samyn-Petit; sylvain julien; Philippe Delannoy
The human sialyltransferase family.
Biochimie 2001;83(8):727-37.
2000: Anne Harduin-Lepers; D C Stokes; Wim F A Steelant; Bénédicte Samyn-Petit; Marie-Ange Krzewinski-Recchi; V Vallejo-Ruiz; Jean-Pierre Zanetta; Claudine Augé; Philippe Delannoy
Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV.
The Biochemical journal 2000;352 Pt 1():37-48.
2000: Bénédicte Samyn-Petit; Marie-Ange Krzewinski-Recchi; Wim F A Steelant; Philippe Delannoy; Anne Harduin-Lepers
Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells.
Biochimica et biophysica acta 2000;1474(2):201-11.
2000: Jean-Philippe Peyrat; MA Recchi; Mohamed Hebbar; Valérie Pawlowski; Louis Hornez; X Dong-Lebouhris; Hubert Hondermarck; Anne Harduin-Lepers; Philippe Delannoy
Regulation of sialyltransferase expression by estradiol and 4-OH-tamoxifen in the human breast cancer cell MCF-7.
Molecular cell biology research communications : MCBRC 2000;3(1):48-52.
1999: Dominique Mercier; Anne Wierinckx; Ahmad Oulmouden; Paul François Gallet; Monica Palcic; Anne Harduin-Lepers; Philippe Delannoy; Jean-Michel Petit; Hubert Levéziel; Raymond Julien
Molecular cloning, expression and exon/intron organization of the bovine beta-galactoside alpha2,6-sialyltransferase gene.
Glycobiology 1999;9(9):851-63.
1998: MA Recchi; Mohamed Hebbar; Louis Hornez; Anne Harduin-Lepers; Jean-Philippe Peyrat; Philippe Delannoy
Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer.
Cancer research 1998;58(18):4066-70.
1998: MA Recchi; Anne Harduin-Lepers; Y Boilly-Marer; A Verbert; Philippe Delannoy
Multiplex RT-PCR method for the analysis of the expression of human sialyltransferases: application to breast cancer cells.
Glycoconjugate journal 1998;15(1):19-27.
1997: Valérie Giordanengo; Sylvie Bannwarth; C Laffont; V Van Miegem; Anne Harduin-Lepers; Philippe Delannoy; Jean-Claude Lefebvre
Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line.
European journal of biochemistry / FEBS 1997;247(2):558-66.
1997: M Lopez; Bernadette Coddeville; J Langridge; YD Plancke; P Sautière; Hassan CHAABIHI; Frédéric Chirat; Anne Harduin-Lepers; Martine Cerutti; A Verbert; Philippe Delannoy
Microheterogeneity of the oligosaccharides carried by the recombinant bovine lactoferrin expressed in Mamestra brassicae cells.
Glycobiology 1997;7(5):635-51.
1997: Roberto Geremia; Anne Harduin-Lepers; Philippe Delannoy
Identification of two novel conserved amino acid residues in eukaryotic sialyltransferases: implications for their mechanism of action.
Glycobiology 1997;7(2):v-vii.
1995: Anne Harduin-Lepers; MA Recchi; Philippe Delannoy
1994, the year of sialyltransferases.
Glycobiology 1995;5(8):741-58.