Username

Password

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

John Hardy

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Physiology

Chemicals & Drugs

Anatomy

Brain

Concepts & Ideas

Genes & Molecular Sequences

Procedures

DNA Mutational Analysis

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Dickson Dennis W; Braak Heiko; Duda John E; Duyckaerts Charles; Gasser Thomas; Halliday Glenda M; Hardy John; Leverenz James B; Del Tredici Kelly; Wszolek Zbigniew K; Litvan Irene
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.
Hardy John; Trabzuni Danyah; Ryten Mina
Whole genome expression as a quantitative trait.
Rohrer J D; Guerreiro R; Vandrovcova J; Uphill J; Reiman D; Beck J; Isaacs A M; Authier A; Ferrari R; Fox N C; Mackenzie I R A; Warren J D; de Silva R; Holton J; Revesz T; Hardy J; Mead S; Rossor M N
The heritability and genetics of frontotemporal lobar degeneration.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of John Hardy (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Dickson Dennis W; Braak Heiko; Duda John E; Duyckaerts Charles; Gasser Thomas; Halliday Glenda M; Hardy John; Leverenz James B; Del Tredici Kelly; Wszolek Zbigniew K; Litvan Irene
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.
Lancet neurology 2009;8(12):1150-7.
2009: Hardy John; Trabzuni Danyah; Ryten Mina
Whole genome expression as a quantitative trait.
Biochemical Society transactions 2009;37(Pt 6):1276-7.
2009: Rohrer J D; Guerreiro R; Vandrovcova J; Uphill J; Reiman D; Beck J; Isaacs A M; Authier A; Ferrari R; Fox N C; Mackenzie I R A; Warren J D; de Silva R; Holton J; Revesz T; Hardy J; Mead S; Rossor M N
The heritability and genetics of frontotemporal lobar degeneration.
Neurology 2009;73(18):1451-6.
2009: Schneider Susanne A; Paisan-Ruiz Coro; Garcia-Gorostiaga Ines; Quinn Niall P; Weber Yvonne G; Lerche Holger; Hardy John; Bhatia Kailash P
GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias.
Movement disorders : official journal of the Movement Disorder Society 2009;24(11):1684-8.
2009: Hardy John
The amyloid hypothesis for Alzheimer's disease: a critical reappraisal.
Journal of neurochemistry 2009;110(4):1129-34.
2009: Neumann Juliane; Bras Jose; Deas Emma; O'Sullivan Sean S; Parkkinen Laura; Lachmann Robin H; Li Abi; Holton Janice; Guerreiro Rita; Paudel Reema; Segarane Badmavady; Singleton Andrew; Lees Andrew; Hardy John; Houlden Henry; Revesz Tamas; Wood Nicholas W
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease.
Brain : a journal of neurology 2009;132(Pt 7):1783-94.
2009: Nalls M A; Guerreiro R J; Simon-Sanchez J; Bras J T; Traynor B J; Gibbs J R; Launer L; Hardy J; Singleton A B
Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.
Neurogenetics 2009;10(3):183-90.
2009: Lees Andrew J; Hardy John; Revesz Tamas
Parkinson's disease.
Lancet 2009;373(9680):2055-66.
2009: Hardy John; Lewis Patrick; Revesz Tamas; Lees Andrew; Paisan-Ruiz Coro
The genetics of Parkinson's syndromes: a critical review.
Current opinion in genetics & development 2009;19(3):254-65.
2009: Ryten Mina; Trabzuni Danyah; Hardy John
Genotypic analysis of gene expression in the dissection of the aetiology of complex neurological and psychiatric diseases.
Briefings in functional genomics & proteomics 2009;8(3):194-8.
2009: Scholz Sonja W; Houlden Henry; Schulte Claudia; Sharma Manu; Li Abi; Berg Daniela; Melchers Anna; Paudel Reema; Gibbs J Raphael; Simon-Sanchez Javier; Paisan-Ruiz Coro; Bras Jose; Ding Jinhui; Chen Honglei; Traynor Bryan J; Arepalli Sampath; Zonozi Ryan R; Revesz Tamas; Holton Janice; Wood Nick; Lees Andrew; Oertel Wolfgang; Wüllner Ullrich; Goldwurm Stefano; Pellecchia Maria Teresa; Illig Thomas; Riess Olaf; Fernandez Hubert H; Rodriguez Ramon L; Okun Michael S; Poewe Werner; Wenning Gregor K; Hardy John A; Singleton Andrew B; Gasser Thomas
SNCA variants are associated with increased risk for multiple system atrophy.
Annals of neurology 2009;65(5):610-4.
2009: Hardy John; Singleton Andrew
Genomewide association studies and human disease.
The New England journal of medicine 2009;360(17):1759-68.
2009: Webster Jennifer A; Gibbs J Raphael; Clarke Jennifer; Ray Monika; Zhang Weixiong; Holmans Peter; Rohrer Kristen; Zhao Alice; Marlowe Lauren; Kaleem Mona; McCorquodale Donald S; Cuello Cindy; Leung Doris; Bryden Leslie; Nath Priti; Zismann Victoria L; Joshipura Keta; Huentelman Matthew J; Hu-Lince Diane; Coon Keith D; Craig David W; Pearson John V; Heward Christopher B; Reiman Eric M; Stephan Dietrich; Hardy John; Myers Amanda J
Genetic control of human brain transcript expression in Alzheimer disease.
American journal of human genetics 2009;84(4):445-58.
2009: Camargos Sarah Teixeira; Dornas Leonardo Oliveira; Momeni Parastoo; Lees Andrew; Hardy John; Singleton Andrew; Cardoso Francisco
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.
Movement disorders : official journal of the Movement Disorder Society 2009;24(5):662-6.
2009: Chiò Adriano; Schymick Jennifer C; Restagno Gabriella; Scholz Sonja W; Lombardo Federica; Lai Shiao-Lin; Mora Gabriele; Fung Hon-Chung; Britton Angela; Arepalli Sampath; Gibbs J Raphael; Nalls Michael; Berger Stephen; Kwee Lydia Coulter; Oddone Eugene Z; Ding Jinhui; Crews Cynthia; Rafferty Ian; Washecka Nicole; Hernandez Dena; Ferrucci Luigi; Bandinelli Stefania; Guralnik Jack; Macciardi Fabio; Torri Federica; Lupoli Sara; Chanock Stephen J; Thomas Gilles; Hunter David J; Gieger Christian; Wichmann H Erich; Calvo Andrea; Mutani Roberto; Battistini Stefania; Giannini Fabio; Caponnetto Claudia; Mancardi Giovanni Luigi; La Bella Vincenzo; Valentino Francesca; Monsurrò Maria Rosaria; Tedeschi Gioacchino; Marinou Kalliopi; Sabatelli Mario; Conte Amelia; Mandrioli Jessica; Sola Patrizia; Salvi Fabrizio; Bartolomei Ilaria; Siciliano Gabriele; Carlesi Cecilia; Orrell Richard W; Talbot Kevin; Simmons Zachary; Connor James; Pioro Erik P; Dunkley Travis; Stephan Dietrich A; Kasperaviciute Dalia; Fisher Elizabeth M; Jabonka Sibylle; Sendtner Michael; Beck Marcus; Bruijn Lucie; Rothstein Jeffrey; Schmidt Silke; Singleton Andrew; Hardy John; Traynor Bryan J
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
Human molecular genetics 2009;18(8):1524-32.
2009: Kalinderi Kallirhoe; Bostantjopoulou Sevasti; Paisan-Ruiz Coro; Katsarou Zoe; Hardy John; Fidani Liana
Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Greece.
Neuroscience letters 2009;452(2):87-9.
2009: Segarane B; Li A; Paudel R; Scholz S; Neumann J; Lees A; Revesz T; Hardy J; Mathias C J; Wood N W; Holton J; Houlden H
Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy.
Neurology 2009;72(13):1185-6.
2009: Nalls Michael A; Simon-Sanchez Javier; Gibbs J Raphael; Paisan-Ruiz Coro; Bras Jose Tomas; Tanaka Toshiko; Matarin Mar; Scholz Sonja; Weitz Charles; Harris Tamara B; Ferrucci Luigi; Hardy John; Singleton Andrew B
Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics.
PLoS genetics 2009;5(3):e1000415.
2009: Schneider Susanne A; Bhatia Kailash P; Hardy John
Complicated recessive dystonia parkinsonism syndromes.
Movement disorders : official journal of the Movement Disorder Society 2009;24(4):490-9.
2009: Momeni Parastoo; Pittman Alan; Lashley Tammaryn; Vandrovcova Jana; Malzer Elke; Luk Connie; Hulette Christine; Lees Andrew; Revesz Tamas; Hardy John; de Silva Rohan
Clinical and pathological features of an Alzheimer's disease patient with the MAPT DeltaK280 mutation.
Neurobiology of aging 2009;30(3):388-93.
2009: Huang Lucy; Li Yun; Singleton Andrew B; Hardy John A; Abecasis Gonçalo; Rosenberg Noah A; Scheet Paul
Genotype-imputation accuracy across worldwide human populations.
American journal of human genetics 2009;84(2):235-50.
2009: Wickremaratchi Mindhu M; Majounie Elisa; Morris Huw R; Williams Nigel M; Lewis Helen; Gill Steven S; Khan Sadaquate; Heywood Peter; Hardy John; Wiles Charles M; Singleton Andrew B; Quinn Niall P
Parkin-related disease clinically diagnosed as a pallido-pyramidal syndrome.
Movement disorders : official journal of the Movement Disorder Society 2009;24(1):138-40.
2009: Paisan-Ruiz Coro; Bhatia Kailash P; Li Abi; Hernandez Dena; Davis Mary; Wood Nick W; Hardy John; Houlden Henry; Singleton Andrew; Schneider Susanne A
Characterization of PLA2G6 as a locus for dystonia-parkinsonism.
Annals of neurology 2009;65(1):19-23.
2008: Bras Jose; Singleton Andrew; Cookson Mark R; Hardy John
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.
The FEBS journal 2008;275(23):5767-73.
2008: Zody Michael C; Jiang Zhaoshi; Fung Hon-Chung; Antonacci Francesca; Hillier LaDeana W; Cardone Maria Francesca; Graves Tina A; Kidd Jeffrey M; Cheng Ze; Abouelleil Amr; Chen Lin; Wallis John; Glasscock Jarret; Wilson Richard K; Reily Amy Denise; Duckworth Jaime; Ventura Mario; Hardy John; Warren Wesley C; Eichler Evan E
Evolutionary toggling of the MAPT 17q21.31 inversion region.
Nature genetics 2008;40(9):1076-83.
2008: Jain Mahim; Wallis Deeann; Robin Nathaniel H; De Vrieze Fabienne Wavrant; Hardy John A; Ghadami Mohsen; Bosse Kristin; Betz Regina C; Nöthen Markus M; Arcos-Burgos Mauricio; Muenke Maximilian
Locus homogeneity between syndactyly type 1A and craniosynostosis Philadelphia type?
American journal of medical genetics. Part A 2008;146A(17):2308-11.
2008: Peuralinna Terhi; Oinas Minna; Polvikoski Tuomo; Paetau Anders; Sulkava Raimo; Niinistö Leena; Kalimo Hannu; Hernandez Dena; Hardy John; Singleton Andrew; Tienari Pentti J; Myllykangas Liisa
Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.
Annals of neurology 2008;64(3):348-52.
2008: Blom Elin S; Holmans Peter; Arepalli Sampath; Adighibe Omanma; Hamshere Marian L; Gatz Margaret; Pedersen Nancy L; Bergem A L Mina; Owen Michael J; Hollingworth Paul; Goate Alison; Williams Julie; Lannfelt Lars; Hardy John; Wavrant-De Vrièze Fabienne; Glaser Anna
Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(6):778-83.
2008: Plun-Favreau Helene; Hardy John
PINK1 in mitochondrial function.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11041-2.
2008: Guerreiro Rita Joao; Santana Isabel; Bras Jose Miguel; Revesz Tamas; Rebelo Olinda; Ribeiro Maria Helena; Santiago Beatriz; Oliveira Catarina Resende; Singleton Andrew; Hardy John
Novel progranulin mutation: screening for PGRN mutations in a Portuguese series of FTD/CBS cases.
Movement disorders : official journal of the Movement Disorder Society 2008;23(9):1269-73.
2008: Rogaeva Ekaterina; Hardy John
Gaucher and Parkinson diseases: unexpectedly related.
Neurology 2008;70(24):2272-3.
2008: Matarin Mar; Brown W Mark; Singleton Andrew; Hardy John A; Meschia James F;
Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.
Stroke; a journal of cerebral circulation 2008;39(5):1586-9.
2008: Matarin Mar; Simon-Sanchez Javier; Fung Hon-Chung; Scholz Sonja; Gibbs J Raphael; Hernandez Dena G; Crews Cynthia; Britton Angela; De Vrieze Fabienne Wavrant; Brott Thomas G; Brown Robert D; Worrall Bradford B; Silliman Scott; Case L Douglas; Hardy John A; Rich Stephen S; Meschia James F; Singleton Andrew B
Structural genomic variation in ischemic stroke.
Neurogenetics 2008;9(2):101-8.
2008: Rohrer Jonathan D; Warren Jason D; Omar Rohani; Mead Simon; Beck Jonathan; Revesz Tamas; Holton Janice; Stevens John M; Al-Sarraj Safa; Pickering-Brown Stuart M; Hardy John; Fox Nick C; Collinge John; Warrington Elizabeth K; Rossor Martin N
Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene.
Archives of neurology 2008;65(4):506-13.
2008: Hardy John; Singleton Andrew
The HapMap: charting a course for genetic discovery in neurological diseases.
Archives of neurology 2008;65(3):319-21.
2008: Camargos Sarah; Scholz Sonja; Simón-Sánchez Javier; Paisán-Ruiz Coro; Lewis Patrick; Hernandez Dena; Ding Jinhui; Gibbs J Raphael; Cookson Mark R; Bras Jose; Guerreiro Rita; Oliveira Catarina Resende; Lees Andrew; Hardy John; Cardoso Francisco; Singleton Andrew B
DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA.
Lancet neurology 2008;7(3):207-15.
2008: Hardy John; Low Nancy; Singleton Andrew
Whole genome association studies: deciding when persistence becomes perseveration.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(2):131-3.
2008: Jakobsson Mattias; Scholz Sonja W; Scheet Paul; Gibbs J Raphael; VanLiere Jenna M; Fung Hon-Chung; Szpiech Zachary A; Degnan James H; Wang Kai; Guerreiro Rita; Bras Jose M; Schymick Jennifer C; Hernandez Dena G; Traynor Bryan J; Simon-Sanchez Javier; Matarin Mar; Britton Angela; van de Leemput Joyce; Rafferty Ian; Bucan Maja; Cann Howard M; Hardy John A; Rosenberg Noah A; Singleton Andrew B
Genotype, haplotype and copy-number variation in worldwide human populations.
Nature 2008;451(7181):998-1003.
2008: Simon-Sanchez Javier; Scholz Sonja; Matarin Maria del Mar; Fung Hon-Chung; Hernandez Dena; Gibbs J Raphael; Britton Angela; Hardy John; Singleton Andrew
Genomewide SNP assay reveals mutations underlying Parkinson disease.
Human mutation 2008;29(2):315-22.
2008: Baum A E; Akula N; Cabanero M; Cardona I; Corona W; Klemens B; Schulze T G; Cichon S; Rietschel M; Nöthen M M; Georgi A; Schumacher J; Schwarz M; Abou Jamra R; Höfels S; Propping P; Satagopan J; Detera-Wadleigh S D; Hardy J; McMahon F J
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
Molecular psychiatry 2008;13(2):197-207.
2008: Camargos Sarah Teixeira; Cardoso Francisco; Momeni Parastoo; Gianetti Juliana Gurgel; Lees Andrew; Hardy John; Singleton Andrew
Novel GCH1 mutation in a Brazilian family with dopa-responsive dystonia.
Movement disorders : official journal of the Movement Disorder Society 2008;23(2):299-302.
2008: Matarin Mar; Brown W Mark; Hardy John A; Rich Stephen S; Singleton Andrew B; Brown Robert D; Brott Thomas G; Worrall Bradford B; Meschia James F;
Association of integrin alpha2 gene variants with ischemic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):81-9.
2008: Okubadejo Njideka; Britton Angela; Crews Cynthia; Akinyemi Rufus; Hardy John; Singleton Andrew; Bras Jose
Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.
PloS one 2008;3(10):e3421.
2008: Cookson Mark R; Hardy John; Lewis Patrick A
Genetic neuropathology of Parkinson's disease.
International journal of clinical and experimental pathology 2008;1(3):217-31.
2008: Hardy John; Gwinn-Hardy Katrina
The relationship between nosology, etiology and pathogenesis in neurodegenerative diseases.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2008;89():189-92.
2008: Guerreiro Rita J; Schymick Jennifer C; Crews Cynthia; Singleton Andrew; Hardy John; Traynor Bryan J
TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis.
PloS one 2008;3(6):e2450.
2008: Tanskanen Maarit; Peuralinna Terhi; Polvikoski Tuomo; Notkola Irma-Leena; Sulkava Raimo; Hardy John; Singleton Andrew; Kiuru-Enari Sari; Paetau Anders; Tienari Pentti J; Myllykangas Liisa
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study.
Annals of medicine 2008;40(3):232-9.
2008: Bras Jose; Guerreiro Rita; Ribeiro Maria; Morgadinho Ana; Januario Cristina; Dias Margarida; Calado Ana; Semedo Cristina; Oliveira Catarina; Hardy John; Singleton Andrew
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.
BMC neurology 2008;8():1.
2008: Webster Jennifer A; Myers Amanda J; Pearson John V; Craig David W; Hu-Lince Diane; Coon Keith D; Zismann Victoria L; Beach Thomas; Leung Doris; Bryden Leslie; Halperin Rebecca F; Marlowe Lauren; Kaleem Mona; Huentelman Matthew J; Joshipura Keta; Walker Douglas; Heward Christopher B; Ravid Rivka; Rogers Joseph; Papassotiropoulos Andreas; Hardy John; Reiman Eric M; Stephan Dietrich A
Sorl1 as an Alzheimer's disease predisposition gene?
Neuro-degenerative diseases 2008;5(2):60-4.
2007: Myers Amanda J; Gibbs J Raphael; Webster Jennifer A; Rohrer Kristen; Zhao Alice; Marlowe Lauren; Kaleem Mona; Leung Doris; Bryden Leslie; Nath Priti; Zismann Victoria L; Joshipura Keta; Huentelman Matthew J; Hu-Lince Diane; Coon Keith D; Craig David W; Pearson John V; Holmans Peter; Heward Christopher B; Reiman Eric M; Stephan Dietrich; Hardy John
A survey of genetic human cortical gene expression.
Nature genetics 2007;39(12):1494-9.
2007: Hamshere Marian L; Holmans Peter A; Avramopoulos Dimitrios; Bassett Susan S; Blacker Deborah; Bertram Lars; Wiener Howard; Rochberg Nan; Tanzi Rudolph E; Myers Amanda; Wavrant-De Vrièze Fabienne; Go Rodney; Fallin Daniele; Lovestone Simon; Hardy John; Goate Alison; O'Donovan Michael; Williams Julie; Owen Michael J
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease.
Human molecular genetics 2007;16(22):2703-12.
2007: Goldstein D S; Imrich R; Peckham E; Holmes C; Lopez G; Crews C; Hardy J; Singleton A; Hallett M
Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.
Neurology 2007;69(16):1580-4.
2007: Hollingworth P; Hamshere M L; Holmans P A; O'Donovan M C; Sims Rebecca; Powell J; Lovestone S; Myers A; DeVrieze F W; Hardy J; Goate A; Owen M; Williams J
Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):841-8.
2007: Bruni A C; Momeni P; Bernardi L; Tomaino C; Frangipane F; Elder J; Kawarai T; Sato C; Pradella S; Wakutani Y; Anfossi M; Gallo M; Geracitano S; Costanzo A; Smirne N; Curcio S A M; Mirabelli M; Puccio G; Colao R; Maletta R G; Kertesz A; St George-Hyslop P; Hardy J; Rogaeva E
Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation.
Neurology 2007;69(2):140-7.
2007: Hardy John; Singleton Andrew
Reporting and interpretation of genetic variants in cases and controls.
Neurology 2007;69(1):111-2.
2007: Fidani L; Clarimon J; Goulas A; Hatzitolios A I; Evans W; Tsirogianni E; Hardy J; Kotsis A
Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2007;14(7):745-9.
2007: Schymick J C; Yang Y; Andersen P M; Vonsattel J P; Greenway M; Momeni P; Elder J; Chiò A; Restagno G; Robberecht W; Dahlberg C; Mukherjee O; Goate A; Graff-Radford N; Caselli R J; Hutton M; Gass J; Cannon A; Rademakers R; Singleton A B; Hardiman O; Rothstein J; Hardy J; Traynor B J
Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes.
Journal of neurology, neurosurgery, and psychiatry 2007;78(7):754-6.
2007: Shrimpton Antony E; Schelper Robert L; Linke Reinhold P; Hardy John; Crook Richard; Dickson Dennis W; Ishizawa Takashi; Davis Richard L
A presenilin 1 mutation (L420R) in a family with early onset Alzheimer disease, seizures and cotton wool plaques, but not spastic paraparesis.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(3):228-32.
2007: van de Leemput Joyce; Chandran Jayanth; Knight Melanie A; Holtzclaw Lynne A; Scholz Sonja; Cookson Mark R; Houlden Henry; Gwinn-Hardy Katrina; Fung Hon-Chung; Lin Xian; Hernandez Dena; Simon-Sanchez Javier; Wood Nick W; Giunti Paola; Rafferty Ian; Hardy John; Storey Elsdon; Gardner R J McKinlay; Forrest Susan M; Fisher Elizabeth M C; Russell James T; Cai Huaibin; Singleton Andrew B
Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.
PLoS genetics 2007;3(6):e108.
2007: Reiman Eric M; Webster Jennifer A; Myers Amanda J; Hardy John; Dunckley Travis; Zismann Victoria L; Joshipura Keta D; Pearson John V; Hu-Lince Diane; Huentelman Matthew J; Craig David W; Coon Keith D; Liang Winnie S; Herbert RiLee H; Beach Thomas; Rohrer Kristen C; Zhao Alice S; Leung Doris; Bryden Leslie; Marlowe Lauren; Kaleem Mona; Mastroeni Diego; Grover Andrew; Heward Christopher B; Ravid Rivka; Rogers Joseph; Hutton Michael L; Melquist Stacey; Petersen Ron C; Alexander Gene E; Caselli Richard J; Kukull Walter; Papassotiropoulos Andreas; Stephan Dietrich A
GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
Neuron 2007;54(5):713-20.
2007: Chen Kewei; Reiman Eric M; Alexander Gene E; Caselli Richard J; Gerkin Richard; Bandy Daniel; Domb Alisa; Osborne David; Fox Nick; Crum William R; Saunders Ann M; Hardy John
Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates.
The American journal of psychiatry 2007;164(6):916-21.
2007: De Ferrari Giancarlo V; Papassotiropoulos Andreas; Biechele Travis; Wavrant De-Vrieze Fabienne; Avila Miguel E; Major Michael B; Myers Amanda; Sáez Katia; Henríquez Juan P; Zhao Alice; Wollmer M Axel; Nitsch Roger M; Hock Christoph; Morris Chris M; Hardy John; Moon Randall T
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9434-9.
2007: Litvan Irene; Chesselet Marie-Francoise; Gasser Thomas; Di Monte Donato A; Parker Davis; Hagg Theo; Hardy John; Jenner Peter; Myers Richard H; Price Donald; Hallett Mark; Langston William J; Lang Anthony E; Halliday Glenda; Rocca Walter; Duyckaerts Charles; Dickson Dennis W; Ben-Shlomo Yoav; Goetz Christopher G; Melamed Eldad
The etiopathogenesis of Parkinson disease and suggestions for future research. Part II.
Journal of neuropathology and experimental neurology 2007;66(5):329-36.
2007: Low Nancy C; Hardy John
What is a schizophrenic mouse?
Neuron 2007;54(3):348-9.
2007: Matarín Mar; Brown W Mark; Scholz Sonja; Simón-Sánchez Javier; Fung Hon-Chung; Hernandez Dena; Gibbs J Raphael; De Vrieze Fabienne Wavrant; Crews Cynthia; Britton Angela; Langefeld Carl D; Brott Thomas G; Brown Robert D; Worrall Bradford B; Frankel Michael; Silliman Scott; Case L Douglas; Singleton Andrew; Hardy John A; Rich Stephen S; Meschia James F
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.
Lancet neurology 2007;6(5):414-20.
2007: Coon Keith D; Myers Amanda J; Craig David W; Webster Jennifer A; Pearson John V; Lince Diane Hu; Zismann Victoria L; Beach Thomas G; Leung Doris; Bryden Leslie; Halperin Rebecca F; Marlowe Lauren; Kaleem Mona; Walker Douglas G; Ravid Rivka; Heward Christopher B; Rogers Joseph; Papassotiropoulos Andreas; Reiman Eric M; Hardy John; Stephan Dietrich A
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
The Journal of clinical psychiatry 2007;68(4):613-8.
2007: Litvan Irene; Halliday Glenda; Hallett Mark; Goetz Christopher G; Rocca Walter; Duyckaerts Charles; Ben-Shlomo Yoav; Dickson Dennis W; Lang Anthony E; Chesselet Marie-Francoise; Langston William J; Di Monte Donato A; Gasser Thomas; Hagg Theo; Hardy John; Jenner Peter; Melamed Eldad; Myers Richard H; Parker Davis; Price Donald L
The etiopathogenesis of Parkinson disease and suggestions for future research. Part I.
Journal of neuropathology and experimental neurology 2007;66(4):251-7.
2007: Schymick Jennifer C; Scholz Sonja W; Fung Hon-Chung; Britton Angela; Arepalli Sampath; Gibbs J Raphael; Lombardo Federica; Matarin Mar; Kasperaviciute Dalia; Hernandez Dena G; Crews Cynthia; Bruijn Lucie; Rothstein Jeffrey; Mora Gabriele; Restagno Gabriella; Chiò Adriano; Singleton Andrew; Hardy John; Traynor Bryan J
Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data.
Lancet neurology 2007;6(4):322-8.
2007: Brown Abraham M; Gordon Derek; Lee Hsinhwa; Wavrant-De Vrièze Fabienne; Cellini Elena; Bagnoli Silvia; Nacmias Benedetta; Sorbi Sandro; Hardy John; Blass John P
Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.
Neurochemical research 2007;32(4-5):857-69.
2007: Worrall Bradford B; Brott Thomas G; Brown Robert D; Brown W Mark; Rich Stephen S; Arepalli Sampath; Wavrant-De Vrièze Fabienne; Duckworth Jaime; Singleton Andrew B; Hardy John; Meschia James F;
IL1RN VNTR polymorphism in ischemic stroke: analysis in 3 populations.
Stroke; a journal of cerebral circulation 2007;38(4):1189-96.
2007: Wavrant-De Vrièze Fabienne; Compton Danielle; Womick Meridith; Arepalli Sampath; Adighibe Omanma; Li Ling; Pérez-Tur Jordi; Hardy John
ABCA1 polymorphisms and Alzheimer's disease.
Neuroscience letters 2007;416(2):180-3.
2007: Hardy John
Does Abeta 42 have a function related to blood homeostasis?
Neurochemical research 2007;32(4-5):833-5.
2007: Lippa C F; Duda J E; Grossman M; Hurtig H I; Aarsland D; Boeve B F; Brooks D J; Dickson D W; Dubois B; Emre M; Fahn S; Farmer J M; Galasko D; Galvin J E; Goetz C G; Growdon J H; Gwinn-Hardy K A; Hardy J; Heutink P; Iwatsubo T; Kosaka K; Lee V M-Y; Leverenz J B; Masliah E; McKeith I G; Nussbaum R L; Olanow C W; Ravina B M; Singleton A B; Tanner C M; Trojanowski J Q; Wszolek Z K;
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.
Neurology 2007;68(11):812-9.
2007: Myers Amanda J; Pittman Alan M; Zhao Alice S; Rohrer Kristen; Kaleem Mona; Marlowe Lauren; Lees Andrew; Leung Doris; McKeith Ian G; Perry Robert H; Morris Chris M; Trojanowski John Q; Clark Christopher; Karlawish Jason; Arnold Steve; Forman Mark S; Van Deerlin Vivianna; de Silva Rohan; Hardy John
The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.
Neurobiology of disease 2007;25(3):561-70.
2007: Hardy John; Myers Amanda
Genetic variability in expression of proteins and the risk of sporadic neurologic diseases.
Neurology 2007;68(9):632-3.
2007: Wiklund P G; Brown W M; Brott T G; Stegmayr B; Brown R D; Nilsson-Ardnor S; Hardy J A; Kissela B M; Singleton A; Holmberg D; Rich S S; Meschia J F
Lack of aggregation of ischemic stroke subtypes within affected sibling pairs.
Neurology 2007;68(6):427-31.
2007: Hardy John
Putting presenilins centre stage. Introduction to the Talking Point on the role of presenilin mutations in Alzheimer disease.
EMBO reports 2007;8(2):134-5.
2007: Simon-Sanchez Javier; Scholz Sonja; Fung Hon-Chung; Matarin Mar; Hernandez Dena; Gibbs J Raphael; Britton Angela; de Vrieze Fabienne Wavrant; Peckham Elizabeth; Gwinn-Hardy Katrina; Crawley Anthony; Keen Judith C; Nash Josefina; Borgaonkar Digamber; Hardy John; Singleton Andrew
Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals.
Human molecular genetics 2007;16(1):1-14.
2007: Gwinn Katrina; Corriveau Roderick A; Mitsumoto Hiroshi; Bednarz Kate; Brown Robert H; Cudkowicz Merit; Gordon Paul H; Hardy John; Kasarskis Edward J; Kaufmann Petra; Miller Robert; Sorenson Eric; Tandan Rup; Traynor Bryan J; Nash Josefina; Sherman Alex; Mailman Matthew D; Ostell James; Bruijn Lucie; Cwik Valerie; Rich Stephen S; Singleton Andrew; Refolo Larry; Andrews Jaime; Zhang Ran; Conwit Robin; Keller Margaret A;
Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.
PloS one 2007;2(12):e1254.
2007: Low Nancy C P; Hardy John
Psychiatric disorder criteria and their application to research in different racial groups.
BMC psychiatry 2007;7():1.
2006: Cookson Mark R; Hardy John
The persistence of memory.
The New England journal of medicine 2006;355(25):2697-8.
2006: Momeni Parastoo; Bell Jason; Duckworth Jaime; Hutton Mike; Mann David; Brown Stuart Pickering; Hardy John
Sequence analysis of all identified open reading frames on the frontal temporal dementia haplotype on chromosome 3 fails to identify unique coding variants except in CHMP2B.
Neuroscience letters 2006;410(2):77-9.
2006: Fung Hon-Chung; Scholz Sonja; Matarin Mar; Simón-Sánchez Javier; Hernandez Dena; Britton Angela; Gibbs J Raphael; Langefeld Carl; Stiegert Matt L; Schymick Jennifer; Okun Michael S; Mandel Ronald J; Fernandez Hubert H; Foote Kelly D; Rodríguez Ramón L; Peckham Elizabeth; De Vrieze Fabienne Wavrant; Gwinn-Hardy Katrina; Hardy John A; Singleton Andrew
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.
Lancet neurology 2006;5(11):911-6.
2006: Masellis Mario; Momeni Parastoo; Meschino Wendy; Heffner Reid; Elder Joshua; Sato Christine; Liang Yan; St George-Hyslop Peter; Hardy John; Bilbao Juan; Black Sandra; Rogaeva Ekaterina
Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome.
Brain : a journal of neurology 2006;129(Pt 11):3115-23.
2006: Seal J L; Gornick M C; Gogtay N; Shaw P; Greenstein D K; Coffey M; Gochman P A; Stromberg T; Chen Z; Merriman B; Nelson S F; Brooks J; Arepalli S; Wavrant-De Vrièze F; Hardy J; Rapoport J L; Addington A M
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia.
Journal of medical genetics 2006;43(11):887-92.
2006: Hardy John; Cai Huaiban; Cookson Mark R; Gwinn-Hardy Katrina; Singleton Andrew
Genetics of Parkinson's disease and parkinsonism.
Annals of neurology 2006;60(4):389-98.
2006: Hardy John
A hundred years of Alzheimer's disease research.
Neuron 2006;52(1):3-13.
2006: Hardy John
No definitive evidence for a role for the environment in the etiology of Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(10):1790-1.
2006: Adighibe Omanma; Arepalli Sampath; Duckworth Jaime; Hardy John; Wavrant-De Vrièze Fabienne
Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease.
Neurobiology of aging 2006;27(10):1431-4.
2006: Huey Edward D; Grafman Jordan; Wassermann Eric M; Pietrini Pietro; Tierney Michael C; Ghetti Bernardino; Spina Salvatore; Baker Matt; Hutton Mike; Elder Joshua W; Berger Stephen L; Heflin Kyle A; Hardy John; Momeni Parastoo
Characteristics of frontotemporal dementia patients with a Progranulin mutation.
Annals of neurology 2006;60(3):374-80.
2006: Li Yonghong; Grupe Andrew; Rowland Charles; Nowotny Petra; Kauwe John S K; Smemo Scott; Hinrichs Anthony; Tacey Kristina; Toombs Timothy A; Kwok Shirley; Catanese Joseph; White Thomas J; Maxwell Taylor J; Hollingworth Paul; Abraham Richard; Rubinsztein David C; Brayne Carol; Wavrant-De Vrièze Fabienne; Hardy John; O'Donovan Michael; Lovestone Simon; Morris John C; Thal Leon J; Owen Michael; Williams Julie; Goate Alison
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.
Human molecular genetics 2006;15(17):2560-8.
2006: Hardy John
Bad luck: an unappreciated limitation in the interpretation of twin studies.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(6):681.
2006: Shatunov Alexey; Sambuughin Nyamkhishig; Jankovic Joseph; Elble Rodger; Lee Hee Suk; Singleton Andrew B; Dagvadorj Ayush; Ji Jay; Zhang Yiping; Kimonis Virginia E; Hardy John; Hallett Mark; Goldfarb Lev G
Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23.
Brain : a journal of neurology 2006;129(Pt 9):2318-31.
2006: Hardy John; Cullen Karen
Amyloid at the blood vessel wall.
Nature medicine 2006;12(7):756-7.
2006: Fidani Liana; Kalinderi Kallirhoe; Bostantjopoulou Sevasti; Clarimon Jordi; Goulas Antonis; Katsarou Zoe; Hardy John; Kotsis Alexandros
Association of the Tau haplotype with Parkinson's disease in the Greek population.
Movement disorders : official journal of the Movement Disorder Society 2006;21(7):1036-9.
2006: Hardy John; Orr Harry
The genetics of neurodegenerative diseases.
Journal of neurochemistry 2006;97(6):1690-9.
2006: Clarimon Jordi; Scholz Sonja; Fung Hon-Chung; Hardy John; Eerola Johanna; Hellstrom Olli; Chen Chiung-Mei; Wu Yih-Ru; Tienari Pentti J; Singleton Andrew
Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease.
American journal of human genetics 2006;78(6):1082-4; author reply 1092-4.
2006: Merikangas Kathleen Ries; Low Nancy C P; Hardy John
Commentary: understanding sources of complexity in chronic diseases--the importance of integration of genetics and epidemiology.
International journal of epidemiology 2006;35(3):590-2; discussion 593-6.
2006: Fung Hon-Chung; Chen Chiung-Mei; Hardy John; Hernandez Dena; Singleton Andrew; Wu Yih-Ru
Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(6):880-1.
2006: Malkani Roneil; D'Souza Ian; Gwinn-Hardy Katrina; Schellenberg Gerard D; Hardy John; Momeni Parastoo
A MAPT mutation in a regulatory element upstream of exon 10 causes frontotemporal dementia.
Neurobiology of disease 2006;22(2):401-3.
2006: Edwards-Lee Terri; Wen Johnny; Bell Jason; Hardy John; Chung Julia; Momeni Parastoo
A presenilin-1 mutation (T245P) in transmembrane domain 6 causes early onset Alzheimer's disease.
Neuroscience letters 2006;398(3):251-2.
2006: Momeni Parastoo; Cairns Nigel J; Perry Robert H; Bigio Eileen H; Gearing Marla; Singleton Andrew B; Hardy John
Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID).
Neurobiology of aging 2006;27(5):778.e1-778.e6.
2006: Hardy John; Momeni Parastoo; Traynor Bryan J
Frontal temporal dementia: dissecting the aetiology and pathogenesis.
Brain : a journal of neurology 2006;129(Pt 4):830-1.
2006: Hardy John
Has the amyloid cascade hypothesis for Alzheimer's disease been proved?
Current Alzheimer research 2006;3(1):71-3.
2006: Fung Hon-Chung; Chen Chiung-Mei; Hardy John; Singleton Andrew B; Lee-Chen Guey-Jen; Wu Yih-Ru
Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan.
Neuroscience letters 2006;394(1):33-6.
2006: Hardy John; Pittman Alan; Myers Amanda; Fung Hon Chung; de Silva Rohan; Duckworth Jaime
Tangle diseases and the tau haplotypes.
Alzheimer disease and associated disorders 2006;20(1):60-2.
2006: Grupe Andrew; Li Yonghong; Rowland Charles; Nowotny Petra; Hinrichs Anthony L; Smemo Scott; Kauwe John S K; Maxwell Taylor J; Cherny Sara; Doil Lisa; Tacey Kristina; van Luchene Ryan; Myers Amanda; Wavrant-De Vrièze Fabienne; Kaleem Mona; Hollingworth Paul; Jehu Luke; Foy Catherine; Archer Nicola; Hamilton Gillian; Holmans Peter; Morris Chris M; Catanese Joseph; Sninsky John; White Thomas J; Powell John; Hardy John; O'Donovan Michael; Lovestone Simon; Jones Lesley; Morris John C; Thal Leon; Owen Michael; Williams Julie; Goate Alison
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
American journal of human genetics 2006;78(1):78-88.
2006: Hardy John
Amyloid double trouble.
Nature genetics 2006;38(1):11-2.
2006: Hardy John; Scholz Sonja; Evans Whitney; Goldfarb Lev; Singleton Andrew
Prion genotypes in Central America suggest selection for the V129 allele.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(1):33-5.
2006: Smemo Scott; Nowotny Petra; Hinrichs Anthony L; Kauwe John S K; Cherny Sara; Erickson Katherine; Myers Amanda J; Kaleem Mona; Marlowe Lauren; Gibson Alison M; Hollingworth Paul; O'Donovan Michael C; Morris Chris M; Holmans Peter; Lovestone Simon; Morris John C; Thal Leon; Li Yonghong; Grupe Andrew; Hardy John; Owen Michael J; Williams Julie; Goate Alison
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.
Annals of neurology 2006;59(1):21-6.
2006: Garcia Michael L; Singleton Andrew B; Hernandez Dena; Ward Christopher M; Evey Crystal; Sapp Peter A; Hardy John; Brown Robert H; Cleveland Don W
Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis.
Neurobiology of disease 2006;21(1):102-9.
2006: Fung H C; Xiromerisiou G; Gibbs J R; Wu Y R; Eerola J; Gourbali V; Hellström O; Chen C M; Duckworth J; Papadimitriou A; Tienari P J; Hadjigeorgiou G M; Hardy J; Singleton A B
Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts.
Neuro-degenerative diseases 2006;3(6):327-33.
2006: Marlowe Lauren; Peila Rita; Benke Kelly Suzanne; Hardy John; White Lon R; Launer Lenore J; Myers Amanda
Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk.
Neuro-degenerative diseases 2006;3(6):320-6.
2006: Fung Hon-Chung; Chen Chiung-Mei; Hardy John; Singleton Andrew B; Wu Yih-Ru
A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan.
BMC neurology 2006;6():47.
2006: Momeni Parastoo; Schymick Jennifer; Jain Shushant; Cookson Mark R; Cairns Nigel J; Greggio Elisa; Greenway Matthew J; Berger Stephen; Pickering-Brown Stuart; Chiò Adriano; Fung Hon Chung; Holtzman David M; Huey Edward D; Wassermann Eric M; Adamson Jennifer; Hutton Michael L; Rogaeva Ekaterina; St George-Hyslop Peter; Rothstein Jeffrey D; Hardiman Orla; Grafman Jordan; Singleton Andrew; Hardy John; Traynor Bryan J
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC neurology 2006;6():44.
2006: Momeni Parastoo; Rogaeva Ekaterina; Van Deerlin Vivianna; Yuan Wuxing; Grafman Jordan; Tierney Michael; Huey Edward; Bell Jason; Morris Chris M; Kalaria Rajesh N; van Rensburg Susan J; Niehaus Dana; Potocnik Felix; Kawarai Toshitaka; Salehi-Rad Shabnam; Sato Christine; St George-Hyslop Peter; Hardy John
Genetic variability in CHMP2B and frontotemporal dementia.
Neuro-degenerative diseases 2006;3(3):129-33.
2006: Hardy John
Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):151-3.
2006: Guerreiro Rita J; Bras Jose M; Santana Isabel; Januario Cristina; Santiago Beatriz; Morgadinho Ana S; Ribeiro Maria H; Hardy John; Singleton Andrew; Oliveira Catarina
Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort.
BMC neurology 2006;6():24.
2006: Müller Robert; Mellors Ian; Johannessen Berit; Aarsand Aasne K; Kiefer Paul; Hardy John; Kendall Richard; Scott Colin Stephen
European multi-center evaluation of the Abbott Cell-Dyn sapphire hematology analyzer.
Laboratory hematology : official publication of the International Society for Laboratory Hematology 2006;12(1):15-31.
2005: Ross J R; Goller K; Hardy J; Riley J; Broadley K; A'hern R; Williams J
Gabapentin is effective in the treatment of cancer-related neuropathic pain: a prospective, open-label study.
Journal of palliative medicine 2005;8(6):1118-26.
2005: McKeith I G; Dickson D W; Lowe J; Emre M; O'Brien J T; Feldman H; Cummings J; Duda J E; Lippa C; Perry E K; Aarsland D; Arai H; Ballard C G; Boeve B; Burn D J; Costa D; Del Ser T; Dubois B; Galasko D; Gauthier S; Goetz C G; Gomez-Tortosa E; Halliday G; Hansen L A; Hardy J; Iwatsubo T; Kalaria R N; Kaufer D; Kenny R A; Korczyn A; Kosaka K; Lee V M Y; Lees A; Litvan I; Londos E; Lopez O L; Minoshima S; Mizuno Y; Molina J A; Mukaetova-Ladinska E B; Pasquier F; Perry R H; Schulz J B; Trojanowski J Q; Yamada M;
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology 2005;65(12):1863-72.
2005: Bras Jose Miguel; Guerreiro Rita Joao; Ribeiro Maria Helena; Januario Cristina; Morgadinho Ana; Oliveira Catarina Resende; Cunha Luis; Hardy John; Singleton Andrew
G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort.
Movement disorders : official journal of the Movement Disorder Society 2005;20(12):1653-5.
2005: Hernandez Dena; Paisan Ruiz Coro; Crawley Anthony; Malkani Roneil; Werner John; Gwinn-Hardy Katrina; Dickson Dennis; Wavrant Devrieze Fabienne; Hardy John; Singleton Andrew
The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases.
Neuroscience letters 2005;389(3):137-9.
2005: Momeni Parastoo; Lu Chin-Song; Chou Yah-Huei Wu; Chang Hsiu-Chen; Chen Rou-Shayn; Chen Chiung-Chu; Hsu Jin-Tian; Singleton Andrew; Hardy John
Taiwanese cases of SCA2 are derived from a single founder.
Movement disorders : official journal of the Movement Disorder Society 2005;20(12):1633-6.
2005: Lahiri Debomoy K; Ge Yuan-Wen; Maloney Bryan; Wavrant-De Vrièze Fabienne; Hardy John
Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease.
Neurobiology of aging 2005;26(10):1329-41.
2005: Pittman A M; Myers A J; Abou-Sleiman P; Fung H C; Kaleem M; Marlowe L; Duckworth J; Leung D; Williams D; Kilford L; Thomas N; Morris C M; Dickson D; Wood N W; Hardy J; Lees A J; de Silva R
Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration.
Journal of medical genetics 2005;42(11):837-46.
2005: Mao Allen; Paharkova-Vatchkova Vladislava; Hardy John; Miller Marcia M; Kovats Susan
Estrogen selectively promotes the differentiation of dendritic cells with characteristics of Langerhans cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5146-51.
2005: Rezai-Zadeh Kavon; Shytle Doug; Sun Nan; Mori Takashi; Hou Huayan; Jeanniton Deborah; Ehrhart Jared; Townsend Kirk; Zeng Jin; Morgan David; Hardy John; Town Terrence; Tan Jun
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(38):8807-14.
2005: Meschia James F; Brott Thomas G; Brown Robert D; Crook Richard; Worrall Bradford B; Kissela Brett; Brown W Mark; Rich Stephen S; Case L Douglas; Evans E Whitney; Hague Stephen; Singleton Andrew; Hardy John;
Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.
Annals of neurology 2005;58(3):351-61.
2005: Myllykangas Liisa; Wavrant-De Vrièze Fabienne; Polvikoski Tuomo; Notkola Irma-Leena; Sulkava Raimo; Niinistö Leena; Edland Steven D; Arepalli Sampath; Adighibe Omanma; Compton Danielle; Hardy John; Haltia Matti; Tienari Pentti J
Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.
Journal of the neurological sciences 2005;236(1-2):17-24.
2005: Li Y; Rowland C; Tacey K; Catanese J; Sninsky J; Hardy J; Powell J; Lovestone S; Morris J C; Thal L; Goate A; Owen M; Williams J; Grupe A
The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples.
Molecular psychiatry 2005;10(9):809-10.
2005: Hardy John; Lees Andrew J
Parkinson's disease: a broken nosology.
Movement disorders : official journal of the Movement Disorder Society 2005;20 Suppl 12():S2-4.
2005: Kumar-Singh Samir; Pirici Daniel; McGowan Eileen; Serneels Sally; Ceuterick Chantal; Hardy John; Duff Karen; Dickson Dennis; Van Broeckhoven Christine
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.
The American journal of pathology 2005;167(2):527-43.
2005: Hardy J; Pittman A; Myers A; Gwinn-Hardy K; Fung H C; de Silva R; Hutton M; Duckworth J
Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens.
Biochemical Society transactions 2005;33(Pt 4):582-5.
2005: Hardy J
Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration.
Biochemical Society transactions 2005;33(Pt 4):578-81.
2005: Myers A J; Kaleem M; Marlowe L; Pittman A M; Lees A J; Fung H C; Duckworth J; Leung D; Gibson A; Morris C M; de Silva R; Hardy J
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.
Human molecular genetics 2005;14(16):2399-404.
2005: McGowan Eileen; Pickford Fiona; Kim Jungsu; Onstead Luisa; Eriksen Jason; Yu Cindy; Skipper Lisa; Murphy M Paul; Beard Jenny; Das Pritam; Jansen Karen; Delucia Michael; Lin Wen-Lang; Dolios Georgia; Wang Rong; Eckman Christopher B; Dickson Dennis W; Hutton Mike; Hardy John; Golde Todd
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Neuron 2005;47(2):191-9.
2005: Martinez Maria; Brice Alexis; Vaughan Jenny R; Zimprich Alexander; Breteler Monique M B; Meco Giuseppe; Filla Alessandro; Farrer Matthew J; Bétard Christine; Singleton Andrew; Hardy John; De Michele Giuseppe; Bonifati Vincenzo; Oostra Ben A; Gasser Thomas; Wood Nick W; Dürr Alexandra
Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):72-4.
2005: Nowotny Petra; Hinrichs Anthony L; Smemo Scott; Kauwe John S K; Maxwell Taylor; Holmans Peter; Hamshere Marian; Turic Dragana; Jehu Luke; Hollingworth Paul; Moore Pamela; Bryden Leslie; Myers Amanda; Doil Lisa M; Tacey Kristina M; Gibson Alison M; McKeith Ian G; Perry Robert H; Morris Chris M; Thal Leon; Morris John C; O'Donovan Michael C; Lovestone Simon; Grupe Andrew; Hardy John; Owen Michael J; Williams Julie; Goate Alison
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):62-8.
2005: Reiman Eric M; Chen Kewei; Alexander Gene E; Caselli Richard J; Bandy Daniel; Osborne David; Saunders Ann M; Hardy John
Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8299-302.
2005: Clarimon Jordi; Asgeirsson Hilmir; Singleton Andrew; Jakobsson Finnbogi; Hjaltason Haukur; Hardy John; Sveinbjornsdottir Sigurlaug
Torsin A haplotype predisposes to idiopathic dystonia.
Annals of neurology 2005;57(5):765-7.
2005: Holmans Peter; Hamshere Marian; Hollingworth Paul; Rice Frances; Tunstall Nigel; Jones Sue; Moore Pamela; Wavrant DeVrieze Fabienne; Myers Amanda; Crook Richard; Compton Danielle; Marshall Helen; Meyer David; Shears Shantia; Booth Jeremy; Ramic Dzanan; Williams Nigel; Norton Nadine; Abraham Richard; Kehoe Pat; Williams Hywel; Rudrasingham Varuni; O'Donovan Mick; Jones Lesley; Hardy John; Goate Alison; Lovestone Simon; Owen Michael; Williams Julie
Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;135B(1):24-32.
2005: Bobb Aaron J; Addington Anjene M; Sidransky Ellen; Gornick Michele C; Lerch Jason P; Greenstein Deanna K; Clasen Liv S; Sharp Wendy S; Inoff-Germain Gale; Wavrant-De Vrièze Fabienne; Arcos-Burgos Mauricio; Straub Richard E; Hardy John A; Castellanos F Xavier; Rapoport Judith L
Support for association between ADHD and two candidate genes: NET1 and DRD1.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;134B(1):67-72.
2005: Meschia J F; Brott T G; Brown R D; Kissela B M; Hardy J A; Brown W M; Rich S S;
Correlation of proband and sibling stroke latency: the SWISS Study.
Neurology 2005;64(6):1061-3.
2005: Fung Hon Chung; Evans Jessica; Evans Whitney; Duckworth Jaime; Pittman Alan; de Silva Rohan; Myers Amanda; Hardy John
The architecture of the tau haplotype block in different ethnicities.
Neuroscience letters 2005;377(2):81-4.
2005: Li Yonghong; Hollingworth Paul; Moore Pamela; Foy Catherine; Archer Nicola; Powell John; Nowotny Petra; Holmans Peter; O'Donovan Michael; Tacey Kristina; Doil Lisa; van Luchene Ryan; Garcia Veronica; Rowland Charles; Lau Kit; Cantanese Joseph; Sninsky John; Hardy John; Thal Leon; Morris John C; Goate Alison; Lovestone Simon; Owen Michael; Williams Julie; Grupe Andrew
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.
Human mutation 2005;25(3):270-7.
2005: Miller David W; Crawley Anthony; Gwinn-Hardy Katrina; Lopez Grisel; Nussbaum Robert; Cookson Mark R; Singleton Andrew B; Hardy John; Dogu Okan
Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.
Neuroscience letters 2005;374(3):189-91.
2005: Clarimon Jordi; Johnson Janel; Dogu Okan; Horta Wagner; Khan Naheed; Lees Andrew J; Hardy John; Singleton Andrew
Defining the ends of Parkin exon 4 deletions in two different families with Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;133B(1):120-3.
2005: Edwards-Lee T; Ringman J M; Chung J; Werner J; Morgan A; St George Hyslop P; Thompson P; Dutton R; Mlikotic A; Rogaeva E; Hardy J
An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.
Neurology 2005;64(2):377-9.
2005: McInerney-Leo Aideen; Hadley Donald W; Gwinn-Hardy Katrina; Hardy John
Genetic testing in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2005;20(1):1-10.
2005: Papassotiropoulos Andreas; Lambert Jean-Charles; Wavrant-De Vrièze Fabienne; Wollmer M Axel; von der Kammer Heinz; Streffer Johannes R; Maddalena Alessia; Huynh Kim-Dung; Wolleb Sibylle; Lutjohann Dieter; Schneider Brigitte; Thal Dietmar R; Grimaldi Luigi M E; Tsolaki Magdalini; Kapaki Elisabeth; Ravid Rivka; Konietzko Uwe; Hegi Thomas; Pasch Thomas; Jung Hans; Braak Heiko; Amouyel Philippe; Rogaev Evgeny I; Hardy John; Hock Christoph; Nitsch Roger M
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.
Neuro-degenerative diseases 2005;2(5):233-41.
2004: Rogaeva Ekaterina; Johnson Janel; Lang Anthony E; Gulick Cindy; Gwinn-Hardy Katrina; Kawarai Toshitaka; Sato Christine; Morgan Angharad; Werner John; Nussbaum Robert; Petit Agnes; Okun Michael S; McInerney Aideen; Mandel Ronald; Groen Justus L; Fernandez Hubert H; Postuma Ron; Foote Kelly D; Salehi-Rad Shabnam; Liang Yan; Reimsnider Sharon; Tandon Anurag; Hardy John; St George-Hyslop Peter; Singleton Andrew B
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.
Archives of neurology 2004;61(12):1898-904.
2004: Morris Huw R; Steele John C; Crook Richard; Wavrant-De Vrièze Fabienne; Onstead-Cardinale Luisa; Gwinn-Hardy Katrina; Wood Nick W; Farrer Matthew; Lees Andrew J; McGeer P L; Siddique Teepu; Hardy John; Perez-Tur Jordi
Genome-wide analysis of the parkinsonism-dementia complex of Guam.
Archives of neurology 2004;61(12):1889-97.
2004: Martinez M; Brice A; Vaughan J R; Zimprich A; Breteler M M B; Meco G; Filla A; Farrer M J; Bétard C; Hardy J; De Michele G; Bonifati V; Oostra B; Gasser T; Wood N W; Dürr A;
Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease.
Journal of medical genetics 2004;41(12):900-7.
2004: Busby J; O'Brien K K; Gibson A M; McKeith I G; Perry R H; Hardy J A; Singleton A B; Morris C M
Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene.
Neurogenetics 2004;5(4):251-2.
2004: Hanson Melissa; Honour Melissa; Singleton Amanda; Crawley Anthony; Singleton Andrew; Hardy John; Gwinn-Hardy Katrina
Analysis of familial and sporadic restless legs syndrome in age of onset, gender, and severity features.
Journal of neurology 2004;251(11):1398-401.
2004: Li Yonghong; Nowotny Petra; Holmans Peter; Smemo Scott; Kauwe John S K; Hinrichs Anthony L; Tacey Kristina; Doil Lisa; van Luchene Ryan; Garcia Veronica; Rowland Charles; Schrodi Steve; Leong Diane; Gogic Goran; Chan Joanne; Cravchik Anibal; Ross David; Lau Kit; Kwok Shirley; Chang Sheng-Yung; Catanese Joe; Sninsky John; White Thomas J; Hardy John; Powell John; Lovestone Simon; Morris John C; Thal Leon; Owen Michael; Williams Julie; Goate Alison; Grupe Andrew
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15688-93.
2004: Brown Abraham M; Gordon Derek; Lee Hsinhwa; Caudy Michael; Hardy John; Haroutunian Vahram; Blass John P
Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;131B(1):60-6.
2004: Hardy John
Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer's disease in vivo?
European journal of nuclear medicine and molecular imaging 2004;31(11):1539-40.
2004: Evidente Virgilio Gerald H; Esteban Raymund P; Hernandez Jose Luis; Natividad Filipinas F; Advincula Joel; Gwinn-Hardy Katrina; Hardy John; Singleton Amanda; Singleton Andrew
Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study.
Parkinsonism & related disorders 2004;10(7):407-10.
2004: Evans Whitney; Fung Hon Chung; Steele John; Eerola Johanna; Tienari Pentti; Pittman Alan; Silva Rohan de; Myers Amanda; Vrieze Fabienne Wavrant-De; Singleton Andrew; Hardy John
The tau H2 haplotype is almost exclusively Caucasian in origin.
Neuroscience letters 2004;369(3):183-5.
2004: Hardy John; Langston J William
How many pathways are there to nigral death?
Annals of neurology 2004;56(3):316-8.
2004: Winblad B; Palmer K; Kivipelto M; Jelic V; Fratiglioni L; Wahlund L-O; Nordberg A; Bäckman L; Albert M; Almkvist O; Arai H; Basun H; Blennow K; de Leon M; DeCarli C; Erkinjuntti T; Giacobini E; Graff C; Hardy J; Jack C; Jorm A; Ritchie K; van Duijn C; Visser P; Petersen R C
Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.
Journal of internal medicine 2004;256(3):240-6.
2004: Johnson J; Hague S M; Hanson M; Gibson A; Wilson K E; Evans E W; Singleton A A; McInerney-Leo A; Nussbaum R L; Hernandez D G; Gallardo M; McKeith I G; Burn D J; Ryu M; Hellstrom O; Ravina B; Eerola J; Perry R H; Jaros E; Tienari P; Weiser R; Gwinn-Hardy K; Morris C M; Hardy J; Singleton A B
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
Neurology 2004;63(3):554-6.
2004: Li Yonghong; Tacey Kristina; Doil Lisa; van Luchene Ryan; Garcia Veronica; Rowland Charles; Schrodi Steve; Leong Diane; Lau Kit; Catanese Joe; Sninsky John; Nowotny Petra; Holmans Peter; Hardy John; Powell John; Lovestone Simon; Thal Leon; Owen Michael; Williams Julie; Goate Alison; Grupe Andrew
Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.
Neuroscience letters 2004;366(3):268-71.
2004: Dogu Okan; Johnson Janel; Hernandez Dena; Hanson Melissa; Hardy John; Apaydin Hulya; Ozekmekçi Sibel; Sevim Serhan; Gwinn-Hardy Katrina; Singleton Andrew
A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion.
Movement disorders : official journal of the Movement Disorder Society 2004;19(7):812-6.
2004: Clark Lorraine N; Afridi Shehla; Mejia-Santana Helen; Harris Juliette; Louis Elan D; Cote Lucien J; Andrews Howard; Singleton Andrew; Wavrant De-Vrieze Fabienne; Hardy John; Mayeux Richard; Fahn Stanley; Waters Cheryl; Ford Blair; Frucht Steven; Ottman Ruth; Marder Karen
Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.
Movement disorders : official journal of the Movement Disorder Society 2004;19(7):796-800.
2004: Coleman Paul; Kurlan Roger; Crook Richard; Werner John; Hardy John
A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5.
Neuroscience letters 2004;364(3):139-40.
2004: Hardy John
The uncertain anatomy of Alzheimer's disease.
Neurobiology of aging 2004;25(6):719-20; discussion 743-6.
2004: Wiley Joseph; Lynch Timothy; Lincoln Sarah; Skipper Lisa; Hulihan Mary; Gosal David; Bisceglio Gina; Kachergus Jennifer; Hardy John; Farrer Matthew J
Parkinson's disease in Ireland: clinical presentation and genetic heterogeneity in patients with parkin mutations.
Movement disorders : official journal of the Movement Disorder Society 2004;19(6):677-81.
2004: Furtado Sarah; Payami Haydeh; Lockhart Paul J; Hanson Melissa; Nutt John G; Singleton Andrew A; Singleton Amanda; Bower Jamel; Utti Ryan J; Bird Thomas D; de la Fuente-Fernandez Raul; Tsuboi Yoshio; Klimek Mary L; Suchowersky Oksana; Hardy John; Calne Donald B; Wszolek Zbigniew K; Farrer Matthew; Gwinn-Hardy Katrina; Stoessl A Jon
Profile of families with parkinsonism-predominant spinocerebellar ataxia type 2 (SCA2).
Movement disorders : official journal of the Movement Disorder Society 2004;19(6):622-9.
2004: Johnson Janel; Ostojic Jovanka; Lannfelt Lars; Glaser Anna; Basun Hans; Rogaeva Ekaterina; Kawarai Toshitaka; Bruni Amalia; St George Hyslop Peter H; Goate Alison; Pastor Pau; Chakraverty Sumi; Norton Joanne; Morris John C; Hardy John; Singleton Andrew
No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.
Neuroscience letters 2004;363(2):99-101.
2004: Pittman Alan M; Myers Amanda J; Duckworth Jaime; Bryden Leslie; Hanson Melissa; Abou-Sleiman Patrick; Wood Nicholas W; Hardy John; Lees Andrew; de Silva Rohan
The structure of the tau haplotype in controls and in progressive supranuclear palsy.
Human molecular genetics 2004;13(12):1267-74.
2004: Terracciano C M N; Hardy J; Birks E J; Khaghani A; Banner N R; Yacoub M H
Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy.
Circulation 2004;109(19):2263-5.
2004: Singleton Andrew; Myers Amanda; Hardy John
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases.
Human molecular genetics 2004;13 Spec No 1():R123-6.
2004: Petrucelli Leonard; Dickson Dennis; Kehoe Kathryn; Taylor Julie; Snyder Heather; Grover Andrew; De Lucia Michael; McGowan Eileen; Lewis Jada; Prihar Guy; Kim Jungsu; Dillmann Wolfgang H; Browne Susan E; Hall Alexis; Voellmy Richard; Tsuboi Yoshio; Dawson Ted M; Wolozin Benjamin; Hardy John; Hutton Mike
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
Human molecular genetics 2004;13(7):703-14.
2004: Singleton Amanda; Gwinn-Hardy Katrina; Sharabi Yehonotan; Li Sheng-Ting; Holmes Courtney; Dendi Raghuveer; Hardy John; Singleton Andrew; Crawley Anthony; Goldstein David S
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.
Brain : a journal of neurology 2004;127(Pt 4):768-72.
2004: Kirshner Julia; Hardy John; Wilczynski Sharon; Shively John E
Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1 integrin in a 3D model of morphogenesis.
Journal of molecular histology 2004;35(3):287-99.
2004: Fidani Liana; Goulas Antonis; Crook Richard; Petersen Ronald C; Tangalos Eric; Kotsis Alexandros; Hardy John
An association study of the cholesteryl ester transfer protein TaqI B polymorphism with late onset Alzheimer's disease.
Neuroscience letters 2004;357(2):152-4.
2004: Pickering-Brown Stuart; Baker Matt; Bird Thomas; Trojanowski John; Lee Virginia; Morris Huw; Rossor Martin; Janssen John C; Neary David; Craufurd David; Richardson Anna; Snowden Julie; Hardy John; Mann David; Hutton Mike
Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;125B(1):79-82.
2004: Bandopadhyay Rina; Kingsbury Ann E; Cookson Mark R; Reid Andrew R; Evans Ian M; Hope Andrew D; Pittman Alan M; Lashley Tammaryn; Canet-Aviles Rosa; Miller David W; McLendon Chris; Strand Catherine; Leonard Andrew J; Abou-Sleiman Patrick M; Healy Daniel G; Ariga Hiroyashi; Wood Nicholas W; de Silva Rohan; Revesz Tamas; Hardy John A; Lees Andrew J
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.
Brain : a journal of neurology 2004;127(Pt 2):420-30.
2004: Pifl Christian; Khorchide Maya; Kattinger Alexandra; Reither Harald; Hardy John; Hornykiewicz Oleh
alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.
Neuroscience letters 2004;354(1):34-7.
2004: Zimprich Alexander; Müller-Myhsok Bertram; Farrer Matthew; Leitner Petra; Sharma Manu; Hulihan Mary; Lockhart Paul; Strongosky Audrey; Kachergus Jennifer; Calne Donald B; Stoessl Jon; Uitti Ryan J; Pfeiffer Ronald F; Trenkwalder Claudia; Homann Nikolaus; Ott Erwin; Wenzel Karoline; Asmus Friedrich; Hardy John; Wszolek Zbigniew; Gasser Thomas
The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.
American journal of human genetics 2004;74(1):11-9.
2004: Reiman Eric M; Chen Kewei; Alexander Gene E; Caselli Richard J; Bandy Daniel; Osborne David; Saunders Ann M; Hardy John
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):284-9.
2004: Myers Amanda J; Marshall Helen; Holmans Peter; Compton Danielle; Crook Richard J P; Mander Adrian P; Nowotny Petra; Smemo Scott; Dunstan Melanie; Jehu Luke; Wang Jen C; Hamshere Marian; Morris John C; Norton Joanne; Chakraventy Sumi; Tunstall Nigel; Lovestone Simon; Petersen Ronald; O'Donovan Michael; Jones Lesley; Williams Julie; Owen Michael J; Hardy John; Goate Alison
Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;124B(1):29-37.
2004: Hardy John; Myers Amanda; Wavrant-De Vrieze Fabienne
Problems and solutions in the genetic analysis of late-onset Alzheimer's disease.
Neuro-degenerative diseases 2004;1(4-5):213-7.
2004: Busby Victoria; Goossens Steven; Nowotny Petra; Hamilton Gillian; Smemo Scott; Harold Denise; Turic Dragana; Jehu Luke; Myers Amanda; Womick Meredith; Woo Daniel; Compton Danielle; Doil Lisa M; Tacey Kristina M; Lau Kit F; Al-Saraj Safa; Killick Richard; Pickering-Brown Stuart; Moore Pamela; Hollingworth Paul; Archer Nicola; Foy Catherine; Walter Sarah; Lendon Corrine; Iwatsubo Takeshi; Morris John C; Norton Joanne; Mann David; Janssens Barbara; Hardy John; O'Donovan Michael; Jones Lesley; Williams Julie; Holmans Peter; Owen Michael J; Grupe Andrew; Powell John; van Hengel Jolanda; Goate Alison; Van Roy Frans; Lovestone Simon
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Neuromolecular medicine 2004;5(2):133-46.
2004: Hardy John
Toward Alzheimer therapies based on genetic knowledge.
Annual review of medicine 2004;55():15-25.
2003: Morris Christopher M; O'Brien Kirsty K; Gibson Alison M; Hardy John A; Singleton Andrew B
Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease.
Neuroscience letters 2003;352(2):151-3.
2003: Lincoln Sarah J; Maraganore Demetrius M; Lesnick Timothy G; Bounds Rebecca; de Andrade Mariza; Bower James H; Hardy John A; Farrer Matthew J
Parkin variants in North American Parkinson's disease: cases and controls.
Movement disorders : official journal of the Movement Disorder Society 2003;18(11):1306-11.
2003: Maraganore Demetrius M; Farrer Matthew J; Lesnick Timothy G; de Andrade Mariza; Bower James H; Hernandez Dena; Hardy John A; Rocca Walter A
Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2003;18(11):1233-9.
2003: Houlden H; Lincoln S; Farrer M; Cleland P G; Hardy J; Orrell R W
Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic.
Neurology 2003;61(10):1423-6.
2003: Singleton A B; Farrer M; Johnson J; Singleton A; Hague S; Kachergus J; Hulihan M; Peuralinna T; Dutra A; Nussbaum R; Lincoln S; Crawley A; Hanson M; Maraganore D; Adler C; Cookson M R; Muenter M; Baptista M; Miller D; Blancato J; Hardy J; Gwinn-Hardy K
alpha-Synuclein locus triplication causes Parkinson's disease.
Science (New York, N.Y.) 2003;302(5646):841.
2003: Eerola J; Hernandez D; Launes J; Hellström O; Hague S; Gulick C; Johnson J; Peuralinna T; Hardy J; Tienari P J; Singleton A B
Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD.
Neurology 2003;61(7):1000-2.
2003: El-Agnaf Omar M A; Salem Sultan A; Paleologou Katerina E; Cooper Leanne J; Fullwood Nigel J; Gibson Mark J; Curran Martin D; Court Jennifer A; Mann David M A; Ikeda Shu-ichi; Cookson Mark R; Hardy John; Allsop David
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1945-7.
2003: Hardy John
Impact of genetic analysis on Parkinson's disease research.
Movement disorders : official journal of the Movement Disorder Society 2003;18 Suppl 6():S96-8.
2003: Schulze T G; Hardy J; McMahon F J
Inconsistent designs of association studies: a missed opportunity.
Molecular psychiatry 2003;8(9):770-2.
2003: Hague Stephen; Rogaeva Ekaterina; Hernandez Dena; Gulick Cindy; Singleton Amanda; Hanson Melissa; Johnson Janel; Weiser Roberto; Gallardo Marisol; Ravina Bernard; Gwinn-Hardy Katrina; Crawley Anthony; St George-Hyslop Peter H; Lang Anthony E; Heutink Peter; Bonifati Vincenzo; Hardy John; Singleton Andrew
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation.
Annals of neurology 2003;54(2):271-4.
2003: Hardy John
Alzheimer's disease: genetic evidence points to a single pathogenesis.
Annals of neurology 2003;54(2):143-4.
2003: Hernandez Dena; Hanson Melissa; Singleton Amanda; Gwinn-Hardy Katrina; Freeman Jason; Ravina Bernard; Doheny Dana; Gallardo Marisol; Weiser Roberto; Hardy John; Singleton Andrew
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Parkinsonism & related disorders 2003;9(6):317-20.
2003: Harold Denise; Peirce Timothy; Moskvina Valentina; Myers Amanda; Jones Susan; Hollingworth Paul; Moore Pamela; Lovestone Simon; Powell John; Foy Catherine; Archer Nicola; Walter Sarah; Edmonson Amanda; McIlroy Stephen; Craig David; Passmore Peter A; Goate Alison; Hardy John; O'Donovan Michael; Williams Julie; Liddell Malcolm; Owen Michael J; Jones Lesley
Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease.
Human genetics 2003;113(3):258-67.
2003: Meschia James F; Brott Thomas G; Brown Robert D; Crook Richard J P; Frankel Michael; Hardy John; Merino José G; Rich Stephen S; Silliman Scott; Worrall Bradford Burke;
The Ischemic Stroke Genetics Study (ISGS) Protocol.
BMC neurology 2003;3():4.
2003: Meschia James F; Atkinson Elizabeth J; O'Brien Peter C; Brott Thomas G; Brown Robert D; Hardy John
Familial clustering of stroke according to proband age at onset of presenting ischemic stroke.
Stroke; a journal of cerebral circulation 2003;34(7):e89-91.
2003: Tan Louis C; Tanner Caroline M; Chen Rong; Chan Piu; Farrer Matthew; Hardy John; Langston J William
Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutation.
Movement disorders : official journal of the Movement Disorder Society 2003;18(7):758-63.
2003: Frank Richard A; Galasko Douglas; Hampel Harald; Hardy John; de Leon Mony J; Mehta Pankaj D; Rogers Joseph; Siemers Eric; Trojanowski John Q;
Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease.
Neurobiology of aging 2003;24(4):521-36.
2003: Hardy John
The relationship between Lewy body disease, Parkinson's disease, and Alzheimer's disease.
Annals of the New York Academy of Sciences 2003;991():167-70.
2003: Rippon Gregory A; Crook Richard; Baker Matthew; Halvorsen Elizabeth; Chin Steven; Hutton Michael; Houlden Henry; Hardy John; Lynch Timothy
Presenilin 1 mutation in an african american family presenting with atypical Alzheimer dementia.
Archives of neurology 2003;60(6):884-8.
2003: Maraganore Demetrius M; de Andrade Mariza; Lesnick Timothy G; Farrer Matthew J; Bower James H; Hardy John A; Rocca Walter A
Complex interactions in Parkinson's disease: a two-phased approach.
Movement disorders : official journal of the Movement Disorder Society 2003;18(6):631-6.
2003: Marlow Laura; Canet Rosa M; Haugabook Sharie J; Hardy John A; Lahiri Debomoy K; Sambamurti Kumar
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Biochemical and biophysical research communications 2003;305(3):502-9.
2003: Lincoln S; Wiley J; Lynch T; Langston J W; Chen R; Lang A; Rogaeva E; Sa D S; Munhoz R P; Harris J; Marder K; Klein C; Bisceglio G; Hussey J; West A; Hulihan M; Hardy J; Farrer M
Parkin-proven disease: common founders but divergent phenotypes.
Neurology 2003;60(10):1605-10.
2003: Baptista Melisa J; O'Farrell Casey; Hardy John; Cookson Mark R
Microarray analysis reveals induction of heat shock proteins mRNAs by the torsion dystonia protein, TorsinA.
Neuroscience letters 2003;343(1):5-8.
2003: Hardy John; Singleton Andrew; Gwinn-Hardy Katrina
Ethnic differences and disease phenotypes.
Science (New York, N.Y.) 2003;300(5620):739-40.
2003: Baptista Melisa J; O'Farrell Casey; Daya Sneha; Ahmad Rili; Miller David W; Hardy John; Farrer Matthew J; Cookson Mark R
Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines.
Journal of neurochemistry 2003;85(4):957-68.
2003: Hardy John; Cookson Mark R; Singleton Andrew
Genes and parkinsonism.
Lancet neurology 2003;2(4):221-8.
2003: Hardy John
The relationship between amyloid and tau.
Journal of molecular neuroscience : MN 2003;20(2):203-6.
2003: Payami Haydeh; Nutt John; Gancher Steven; Bird Thomas; McNeal Melissa Gonzales; Seltzer William K; Hussey Jennifer; Lockhart Paul; Gwinn-Hardy Katrina; Singleton Amanda A; Singleton Andrew B; Hardy John; Farrer Matthew
SCA2 may present as levodopa-responsive parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2003;18(4):425-9.
2003: Pickford Fiona; Onstead Luisa; Camacho-Prihar Carolina; Hardy John; McGowan Eileen
Expression of mBRI2 in mice.
Neuroscience letters 2003;338(2):95-8.
2002: Petrucelli Leonard; O'Farrell Casey; Lockhart Paul J; Baptista Melisa; Kehoe Kathryn; Vink Liselot; Choi Peter; Wolozin Benjamin; Farrer Matthew; Hardy John; Cookson Mark R
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.
Neuron 2002;36(6):1007-19.
2002: Walker Ruth H; Friedman Joseph; Wiener Jill; Hobler Ronald; Gwinn-Hardy Katrina; Adam Amanda; DeWolfe Jennifer; Gibbs Rebecca; Baker Matt; Farrer Matt; Hutton Mike; Hardy John
A family with a tau P301L mutation presenting with parkinsonism.
Parkinsonism & related disorders 2002;9(2):121-3.
2002: Hardy John
Testing times for the "amyloid cascade hypothesis".
Neurobiology of aging 2002;23(6):1073-4.
2002: Goudreau John L; Maraganore Demetrius M; Farrer Matthew J; Lesnick Timothy G; Singleton Andrew B; Bower James H; Hardy John A; Rocca Walter A
Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2002;17(6):1305-11.
2002: Evidente Virgilio Gerald H; Advincula Joel; Esteban Raymund; Pasco Paul; Alfon Jhoe Anthony; Natividad Filipinas F; Cuanang Joven; Luis Amado San; Gwinn-Hardy Katrina; Hardy John; Hernandez Dena; Singleton Andrew
Phenomenology of "Lubag" or X-linked dystonia-parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2002;17(6):1271-7.
2002: Hardy J
Pathways to primary neurodegenerative disease.
Neurología (Barcelona, Spain) 2002;17(8):399-401.
2002: West Andrew B; Maraganore Demetrius; Crook Julia; Lesnick Tim; Lockhart Paul J; Wilkes Kristen M; Kapatos Gregory; Hardy John A; Farrer Matt J
Functional association of the parkin gene promoter with idiopathic Parkinson's disease.
Human molecular genetics 2002;11(22):2787-92.
2002: Hardy John; Gwinn-Hardy Katrina; McGeer Patrick; Morris Huw; Perez-Tur Jordi; Steele John
Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000.
Neurology 2002;59(7):1121; author reply 1121.
2002: Compton Danielle; Wavrant DeVriéze Fabienne; Petersen Ronald C; Tangalos Eric; Li Ling; Hardy John
Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers.
Neuroscience letters 2002;331(1):60-2.
2002: Subramony S H; Hernandez Dena; Adam Amanda; Smith-Jefferson Stephanie; Hussey Jennifer; Gwinn-Hardy Katrina; Lynch Timothy; McDaniel Olga; Hardy John; Farrer Matt; Singleton Andrew
Ethnic differences in the expression of neurodegenerative disease: Machado-Joseph disease in Africans and Caucasians.
Movement disorders : official journal of the Movement Disorder Society 2002;17(5):1068-71.
2002: Goulas Antonis; Fidani Liana; Kotsis Alexandros; Mirtsou Vassiliki; Petersen Ronald C; Tangalos Eric; Hardy John
An association study of a functional catalase gene polymorphism, -262C-->T, and patients with Alzheimer's disease.
Neuroscience letters 2002;330(2):210-3.
2002: de Silva Rohan; Hardy John; Crook Julia; Khan Naheed; Graham Elizabeth A; Morris Christopher M; Wood Nicholas W; Lees Andrew J
The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease.
Neuroscience letters 2002;330(2):201-3.
2002: Morris H R; Baker M; Yasojima K; Houlden H; Khan M N; Wood N W; Hardy J; Grossman M; Trojanowski J; Revesz T; Bigio E H; Bergeron C; Janssen J C; McGeer P L; Rossor M N; Lees A J; Lantos P L; Hutton M
Analysis of tau haplotypes in Pick's disease.
Neurology 2002;59(3):443-5.
2002: Wu Ruey-Meei; Shan Din-E; Sun Chen-Ming; Liu Ren-Shyan; Hwu Wuh-Liang; Tai Chun-Hwei; Hussey Jennifer; West Andrew; Gwinn-Hardy Katrina; Hardy John; Chen Judy; Farrer Matt; Lincoln Sarah
Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations.
Movement disorders : official journal of the Movement Disorder Society 2002;17(4):670-5.
2002: Hardy John; Selkoe Dennis J
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
Science (New York, N.Y.) 2002;297(5580):353-6.
2002: West Andrew; Periquet Magali; Lincoln Sarah; Lücking Christoph B; Nicholl David; Bonifati Vincenzo; Rawal Nina; Gasser Thomas; Lohmann Ebba; Deleuze Jean-François; Maraganore Demetrius; Levey Allan; Wood Nick; Dürr Alexandra; Hardy John; Brice Alexis; Farrer Matt;
Complex relationship between Parkin mutations and Parkinson disease.
American journal of medical genetics 2002;114(5):584-91.
2002: Lambert J-C; Araria-Goumidi L; Myllykangas L; Ellis C; Wang J C; Bullido M J; Harris J M; Artiga M J; Hernandez D; Kwon J M; Frigard B; Petersen R C; Cumming A M; Pasquier F; Sastre I; Tienari P J; Frank A; Sulkava R; Morris J C; St Clair D; Mann D M; Wavrant-DeVrièze F; Ezquerra-Trabalon M; Amouyel P; Hardy J; Haltia M; Valdivieso F; Goate A M; Pérez-Tur J; Lendon C L; Chartier-Harlin M-C
Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.
Neurology 2002;59(1):59-66.
2002: Lovestone Simon; Hardy John
Psychotic genes or forgetful ones?
Neurology 2002;59(1):11-2.
2002: Taylor J Paul; Hardy John; Fischbeck Kenneth H
Toxic proteins in neurodegenerative disease.
Science (New York, N.Y.) 2002;296(5575):1991-5.
2002: Maraganore Demetrius M; Farrer Matthew J; McDonnell Shannon K; Elbaz Alexis; Schaid Daniel J; Hardy John A; Rocca Walter A
Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2002;17(3):509-12.
2002: Hardy J
[The history of Cushing's disease]
Neuro-Chirurgie 2002;48(2-3 Pt 2):144-8.
2002: Hardy J
[Harvey Cushing (1869-1939)]
Neuro-Chirurgie 2002;48(2-3 Pt 2):142-3.
2002: Pasalar P; Najmabadi H; Noorian A R; Moghimi B; Jannati A; Soltanzadeh A; Krefft T; Crook R; Hardy J
An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).
Neurology 2002;58(10):1574-5.
2002: Henderson J Neil; Crook Richard; Crook Julia; Hardy John; Onstead Luisa; Carson-Henderson Linda; Mayer Pat; Parker Bea; Petersen Ronald; Williams Birdie
Apolipoprotein E4 and tau allele frequencies among Choctaw Indians.
Neuroscience letters 2002;324(1):77-9.
2002: Farrer Matt; Skipper Lisa; Berg Marianne; Bisceglio Gina; Hanson Melissa; Hardy John; Adam Amanda; Gwinn-Hardy Katrina; Aasly Jan
The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population.
Neuroscience letters 2002;322(2):83-6.
2002: Myllykangas Liisa; Polvikoski Tuomo; Reunanen Karoliina; Wavrant-De Vrieze Fabienne; Ellis Clare; Hernandez Dena; Sulkava Raimo; Kontula Kimmo; Verkkoniemi Auli; Notkola Irma-Leena; Hardy John; Perez-Tur Jordi; Haltia Matti J; Tienari Pentti J
ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain.
American journal of medical genetics 2002;114(3):288-91.
2002: Pickering-Brown S M; Richardson A M T; Snowden J S; McDonagh A M; Burns A; Braude W; Baker M; Liu W-K; Yen S-H; Hardy J; Hutton M; Davies Y; Allsop D; Craufurd D; Neary D; Mann D M A
Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene.
Brain : a journal of neurology 2002;125(Pt 4):732-51.
2002: Fidani Liana; Goulas Antonis; Mirtsou Vassiliki; Petersen Ronald C; Tangalos Eric; Crook Richard; Hardy John
Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease.
Neuroscience letters 2002;323(1):81-3.
2002: Fidani Liana; Compton Danielle; Hardy John; Petersen Ronald C; Tangalos Eric; Mirtsou Vassiliki; Goulas Antonis; De Vrieze Fabienne Wavrant
No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease.
Neuroscience letters 2002;322(3):192-4.
2002: Amtul Zareen; Lewis Patrick A; Piper Sian; Crook Richard; Baker Matt; Findlay Kirk; Singleton Andrew; Hogg Marion; Younkin Linda; Younkin Steven G; Hardy John; Hutton Michael; Boeve Bradley F; Tang-Wai David; Golde Todd E
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease 2002;9(2):269-73.
2002: Hardy John
The real problem in association studies.
American journal of medical genetics 2002;114(2):253.
2002: Myers Amanda; Wavrant De-Vrieze Fabienne; Holmans Peter; Hamshere Marian; Crook Richard; Compton Danielle; Marshall Helen; Meyer David; Shears Shantia; Booth Jeremy; Ramic Dzanan; Knowles Heather; Morris John C; Williams Nigel; Norton Nadine; Abraham Richard; Kehoe Pat; Williams Hywel; Rudrasingham Varuni; Rice Francis; Giles Peter; Tunstall Nigel; Jones Lesley; Lovestone Simon; Williams Julie; Owen Michael J; Hardy John; Goate Alison
Full genome screen for Alzheimer disease: stage II analysis.
American journal of medical genetics 2002;114(2):235-44.
2002: Lockhart Paul J; Holtom Benjamin; Lincoln Sarah; Hussey Jennifer; Zimprich Alexander; Gasser Thomas; Wszolek Zbigniew K; Hardy John; Farrer Matthew J
The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3.
Gene 2002;285(1-2):229-37.
2002: Farrer Matt; Hardy John; Hutton Mike; Maraganore Demetrius; Tsuboi Yoshio; Wszolek Zbigniew K
Identifying genetic factors in Parkinson disease.
JAMA : the journal of the American Medical Association 2002;287(6):715-6.
2002: Caselli Richard J; Hentz Joseph G; Osborne David; Graff-Radford Neill R; Barbieri Carolyn J; Alexander Gene E; Hall Geri R; Reiman Eric M; Hardy John; Saunders Ann M
Apolipoprotein E and intellectual achievement.
Journal of the American Geriatrics Society 2002;50(1):49-54.
2002: Evidente Virgilio Gerald H; Gwinn-Hardy Katrina; Hardy John; Hernandez Dena; Singleton Andrew
X-linked dystonia ("Lubag") presenting predominantly with parkinsonism: a more benign phenotype?
Movement disorders : official journal of the Movement Disorder Society 2002;17(1):200-2.
2002: Tang-Wai D; Lewis P; Boeve Bradley; Hutton M; Golde T; Baker M; Hardy J; Michels V; Ivnik R; Jack C; Petersen R
Familial frontotemporal dementia associated with a novel presenilin-1 mutation.
Dementia and geriatric cognitive disorders 2002;14(1):13-21.
2002: Meschia James F; Brown Robert D; Brott Thomas G; Chukwudelunzu Felix E; Hardy John; Rich Stephen S
The Siblings With Ischemic Stroke Study (SWISS) protocol.
BMC medical genetics 2002;3():1.
2002: Boeve B F; Maraganore D M; Parisi J E; Ivnik R J; Westmoreland B F; Dickson D W; Hutton M; Hardy J; Caselli R J; Petersen R C
Corticobasal degeneration and frontotemporal dementia presentations in a kindred with nonspecific histopathology.
Dementia and geriatric cognitive disorders 2002;13(2):80-90.
2001: Abraham R; Myers A; Wavrant-DeVrieze F; Hamshere M L; Thomas H V; Marshall H; Compton D; Spurlock G; Turic D; Hoogendoorn B; Kwon J M; Petersen R C; Tangalos E; Norton J; Morris J C; Bullock R; Liolitsa D; Lovestone S; Hardy J; Goate A; O'Donovan M; Williams J; Owen M J; Jones L
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.
Human genetics 2001;109(6):646-52.
2001: Hardy J; Edinger M; Bachmann M H; Negrin R S; Fathman C G; Contag C H
Bioluminescence imaging of lymphocyte trafficking in vivo.
Experimental hematology 2001;29(12):1353-60.
2001: O'Farrell C; Murphy D D; Petrucelli L; Singleton A B; Hussey J; Farrer M; Hardy J; Dickson D W; Cookson M R
Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells.
Brain research. Molecular brain research 2001;97(1):94-102.
2001: Meschia J F; Brown R D; Brott T G; Hardy J; Atkinson E J; O'Brien P C
Feasibility of an affected sibling pair study in ischemic stroke: results of a 2-center family history registry.
Stroke; a journal of cerebral circulation 2001;32(12):2939-41.
2001: Wilcock D M; Gordon M N; Ugen K E; Gottschall P E; DiCarlo G; Dickey C; Boyett K W; Jantzen P T; Connor K E; Melachrino J; Hardy J; Morgan D
Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels.
DNA and cell biology 2001;20(11):731-6.
2001: Morris H R; Khan M N; Janssen J C; Brown J M; Perez-Tur J; Baker M; Ozansoy M; Hardy J; Hutton M; Wood N W; Lees A J; Revesz T; Lantos P; Rossor M N
The genetic and pathological classification of familial frontotemporal dementia.
Archives of neurology 2001;58(11):1813-6.
2001: Maraganore D M; Hernandez D G; Singleton A B; Farrer M J; McDonnell S K; Hutton M L; Hardy J A; Rocca W A
Case-Control study of the extended tau gene haplotype in Parkinson's disease.
Annals of neurology 2001;50(5):658-61.
2001: Le T V; Crook R; Hardy J; Dickson D W
Cotton wool plaques in non-familial late-onset Alzheimer disease.
Journal of neuropathology and experimental neurology 2001;60(11):1051-61.
2001: Houlden H; Crook R; Dolan R J; McLaughlin J; Revesz T; Hardy J
A novel presenilin mutation (M233V) causing very early onset Alzheimer's disease with Lewy bodies.
Neuroscience letters 2001;313(1-2):93-5.
2001: Morris H R; Al-Sarraj S; Schwab C; Gwinn-Hardy K; Perez-Tur J; Wood N W; Hardy J; Lees A J; McGeer P L; Daniel S E; Steele J C
A clinical and pathological study of motor neurone disease on Guam.
Brain : a journal of neurology 2001;124(Pt 11):2215-22.
2001: Myllykangas L; Polvikoski T; Sulkava R; Notkola I L; Rastas S; Verkkoniemi A; Tienari P J; Niinistö L; Hardy J; Pérez-Tur J; Kontula K; Haltia M
Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study.
Annals of medicine 2001;33(7):486-92.
2001: Liu W K; Le T V; Adamson J; Baker M; Cookson N; Hardy J; Hutton M; Yen S H; Dickson D W
Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy.
Annals of neurology 2001;50(4):494-502.
2001: Choi P; Golts N; Snyder H; Chong M; Petrucelli L; Hardy J; Sparkman D; Cochran E; Lee J M; Wolozin B
Co-association of parkin and alpha-synuclein.
Neuroreport 2001;12(13):2839-43.
2001: West A B; Zimprich A; Lockhart P J; Farrer M; Singleton A; Holtom B; Lincoln S; Hofer A; Hill L; Müller-Myhsok B; Wszolek Z K; Hardy J; Gasser T
Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
European journal of human genetics : EJHG 2001;9(9):659-66.
2001: McCormick W C; Hardy J; Kukull W A; Bowen J D; Teri L; Zitzer S; Larson E B
Healthcare utilization and costs in managed care patients with Alzheimer's disease during the last few years of life.
Journal of the American Geriatrics Society 2001;49(9):1156-60.
2001: Farrer M; Chan P; Chen R; Tan L; Lincoln S; Hernandez D; Forno L; Gwinn-Hardy K; Petrucelli L; Hussey J; Singleton A; Tanner C; Hardy J; Langston J W
Lewy bodies and parkinsonism in families with parkin mutations.
Annals of neurology 2001;50(3):293-300.
2001: West A; Farrer M; Petrucelli L; Cookson M; Lockhart P; Hardy J
Identification and characterization of the human parkin gene promoter.
Journal of neurochemistry 2001;78(5):1146-52.
2001: Caselli R J; Osborne D; Reiman E M; Hentz J G; Barbieri C J; Saunders A M; Hardy J; Graff-Radford N R; Hall G R; Alexander G E
Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study.
Journal of the neurological sciences 2001;189(1-2):93-8.
2001: Farrer M; Maraganore D M; Lockhart P; Singleton A; Lesnick T G; de Andrade M; West A; de Silva R; Hardy J; Hernandez D
alpha-Synuclein gene haplotypes are associated with Parkinson's disease.
Human molecular genetics 2001;10(17):1847-51.
2001: Lewis J; Dickson D W; Lin W L; Chisholm L; Corral A; Jones G; Yen S H; Sahara N; Skipper L; Yager D; Eckman C; Hardy J; Hutton M; McGowan E
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Science (New York, N.Y.) 2001;293(5534):1487-91.
2001: Lewis P A; Piper S; Baker M; Onstead L; Murphy M P; Hardy J; Wang R; McGowan E; Golde T E
Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides.
Biochimica et biophysica acta 2001;1537(1):58-62.
2001: Matsuoka Y; Vila M; Lincoln S; McCormack A; Picciano M; LaFrancois J; Yu X; Dickson D; Langston W J; McGowan E; Farrer M; Hardy J; Duff K; Przedborski S; Di Monte D A
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.
Neurobiology of disease 2001;8(3):535-9.
2001: Houlden H; Baker M; Morris H R; MacDonald N; Pickering-Brown S; Adamson J; Lees A J; Rossor M N; Quinn N P; Kertesz A; Khan M N; Hardy J; Lantos P L; St George-Hyslop P; Munoz D G; Mann D; Lang A E; Bergeron C; Bigio E H; Litvan I; Bhatia K P; Dickson D; Wood N W; Hutton M
Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype.
Neurology 2001;56(12):1702-6.
2001: Polvikoski T; Sulkava R; Myllykangas L; Notkola I L; Niinistö L; Verkkoniemi A; Kainulainen K; Kontula K; Pérez-Tur J; Hardy J; Haltia M
Prevalence of Alzheimer's disease in very elderly people: a prospective neuropathological study.
Neurology 2001;56(12):1690-6.
2001: Hardy J; Crook R
Presenilin mutations line up along transmembrane alpha-helices.
Neuroscience letters 2001;306(3):203-5.
2001: Verkkoniemi A; Kalimo H; Paetau A; Somer M; Iwatsubo T; Hardy J; Haltia M
Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype.
Journal of neuropathology and experimental neurology 2001;60(5):483-92.
2001: Farrer M; Destée A; Levecque C; Singleton A; Engelender S; Becquet E; Mouroux V; Richard F; Defebvre L; Crook R; Hernandez D; Ross C A; Hardy J; Amouyel P; Chartier-Harlin M C
Genetic analysis of synphilin-1 in familial Parkinson's disease.
Neurobiology of disease 2001;8(2):317-23.
2001: Dickson D; Farrer M; Lincoln S; Mason R P; Zimmerman T R; Golbe L I; Hardy J
Pathology of PD in monozygotic twins with a 20-year discordance interval.
Neurology 2001;56(7):981-2.
2001: Steiner H; Revesz T; Neumann M; Romig H; Grim M G; Pesold B; Kretzschmar H A; Hardy J; Holton J L; Baumeister R; Houlden H; Haass C
A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
The Journal of biological chemistry 2001;276(10):7233-9.
2001: Gwinn-Hardy K; Singleton A; O'Suilleabhain P; Boss M; Nicholl D; Adam A; Hussey J; Critchley P; Hardy J; Farrer M
Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family.
Archives of neurology 2001;58(2):296-9.
2001: Hardy J
Genetic dissection of primary neurodegenerative diseases.
Biochemical Society symposium 2001;(67):51-7.
2000: Morgan D; Diamond D M; Gottschall P E; Ugen K E; Dickey C; Hardy J; Duff K; Jantzen P; DiCarlo G; Wilcock D; Connor K; Hatcher J; Hope C; Gordon M; Arendash G W
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
Nature 2000;408(6815):982-5.
2000: Myers A; Holmans P; Marshall H; Kwon J; Meyer D; Ramic D; Shears S; Booth J; DeVrieze F W; Crook R; Hamshere M; Abraham R; Tunstall N; Rice F; Carty S; Lillystone S; Kehoe P; Rudrasingham V; Jones L; Lovestone S; Perez-Tur J; Williams J; Owen M J; Hardy J; Goate A M
Susceptibility locus for Alzheimer's disease on chromosome 10.
Science (New York, N.Y.) 2000;290(5500):2304-5.
2000: Hardy J
Nasal speculum.
Journal of neurosurgery 2000;93(6):1091-2.
2000: Pickering-Brown S; Baker M; Yen S H; Liu W K; Hasegawa M; Cairns N; Lantos P L; Rossor M; Iwatsubo T; Davies Y; Allsop D; Furlong R; Owen F; Hardy J; Mann D; Hutton M
Pick's disease is associated with mutations in the tau gene.
Annals of neurology 2000;48(6):859-67.
2000: Ko L; Mehta N D; Farrer M; Easson C; Hussey J; Yen S; Hardy J; Yen S H
Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.
Journal of neurochemistry 2000;75(6):2546-54.
2000: Farrer M; Destée T; Becquet E; Wavrant-De Vrièze F; Mouroux V; Richard F; Defebvre L; Lincoln S; Hardy J; Amouyel P; Chartier-Harlin M C
Linkage exclusion in French families with probable Parkinson' s disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(6):1075-83.
2000: Houlden H; Baker M; McGowan E; Lewis P; Hutton M; Crook R; Wood N W; Kumar-Singh S; Geddes J; Swash M; Scaravilli F; Holton J L; Lashley T; Tomita T; Hashimoto T; Verkkoniemi A; Kalimo H; Somer M; Paetau A; Martin J J; Van Broeckhoven C; Golde T; Hardy J; Haltia M; Revesz T
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Annals of neurology 2000;48(5):806-8.
2000: Steiner H; Kostka M; Romig H; Basset G; Pesold B; Hardy J; Capell A; Meyn L; Grim M L; Baumeister R; Fechteler K; Haass C
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
Nature cell biology 2000;2(11):848-51.
2000: Lewis P A; Perez-Tur J; Golde T E; Hardy J
The presenilin 1 C92S mutation increases abeta 42 production.
Biochemical and biophysical research communications 2000;277(1):261-3.
2000: Myllykangas L; Polvikoski T; Sulkava R; Verkkoniemi A; Tienari P; Niinistö L; Kontula K; Hardy J; Haltia M; Pérez-Tur J
Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over.
Neuroscience letters 2000;292(3):195-8.
2000: Lambert J C; Goumidi L; Vrièze F W; Frigard B; Harris J M; Cummings A; Coates J; Pasquier F; Cottel D; Gaillac M; St Clair D; Mann D M; Hardy J; Lendon C L; Amouyel P; Chartier-Harlin M C
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease.
Human molecular genetics 2000;9(15):2275-80.
2000: Gwinn-Hardy K; Chen J Y; Liu H C; Liu T Y; Boss M; Seltzer W; Adam A; Singleton A; Koroshetz W; Waters C; Hardy J; Farrer M
Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese.
Neurology 2000;55(6):800-5.
2000: Ostrerova-Golts N; Petrucelli L; Hardy J; Lee J M; Farer M; Wolozin B
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(16):6048-54.
2000: Lewis J; McGowan E; Rockwood J; Melrose H; Nacharaju P; Van Slegtenhorst M; Gwinn-Hardy K; Paul Murphy M; Baker M; Yu X; Duff K; Hardy J; Corral A; Lin W L; Yen S H; Dickson D W; Davies P; Hutton M
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Nature genetics 2000;25(4):402-5.
2000: Maraganore D M; Farrer M J; Hardy J A; McDonnell S K; Schaid D J; Rocca W A
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(4):714-9.
2000: Gwinn-Hardy K; Mehta N D; Farrer M; Maraganore D; Muenter M; Yen S H; Hardy J; Dickson D W
Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p.
Acta neuropathologica 2000;99(6):663-72.
2000: Hardy J
Frameless stereotaxy for transsphenoidal surgery.
Neurosurgery 2000;46(5):1269-70.
2000: Meschia J F; Brott T G; Chukwudelunzu F E; Hardy J; Brown R D; Meissner I; Hall L J; Atkinson E J; O'Brien P C
Verifying the stroke-free phenotype by structured telephone interview.
Stroke; a journal of cerebral circulation 2000;31(5):1076-80.
2000: Baker M; Graff-Radford D; Wavrant DeVrièze F; Graff-Radford N; Petersen R C; Kokmen E; Boeve B; Myllykangas L; Polvikoski T; Sulkava R; Verkoniemmi A; Tienari P; Haltia M; Hardy J; Hutton M; Perez-Tur J
No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease.
Neuroscience letters 2000;285(2):147-9.
2000: Hardy J; Singleton A
The future of genetic analysis of neurological disorders.
Neurobiology of disease 2000;7(2):65-9.
2000: Verkkoniemi A; Somer M; Rinne J O; Myllykangas L; Crook R; Hardy J; Viitanen M; Kalimo H; Haltia M
Variant Alzheimer's disease with spastic paraparesis: clinical characterization.
Neurology 2000;54(5):1103-9.
2000: Gwinn-Hardy K A; Crook R; Lincoln S; Adler C H; Caviness J N; Hardy J; Farrer M
A kindred with Parkinson's disease not showing genetic linkage to established loci.
Neurology 2000;54(2):504-7.
2000: Hardy J
Pathways to primary neurodegenerative disease.
Annals of the New York Academy of Sciences 2000;924():29-34.
1999: Hardy J
Neuronavigation in pituitary surgery.
Surgical neurology 1999;52(6):648-9.
1999: Refolo L M; Eckman C; Prada C M; Yager D; Sambamurti K; Mehta N; Hardy J; Younkin S G
Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
Journal of neurochemistry 1999;73(6):2383-8.
1999: Hardy J; Gwinn-Hardy K
Neurodegenerative disease: a different view of diagnosis.
Molecular medicine today 1999;5(12):514-7.
1999: Maraganore D M; Farrer M J; Hardy J A; Lincoln S J; McDonnell S K; Rocca W A
Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.
Neurology 1999;53(8):1858-60.
1999: Dickson D W; Liu W; Hardy J; Farrer M; Mehta N; Uitti R; Mark M; Zimmerman T; Golbe L; Sage J; Sima A; D'Amato C; Albin R; Gilman S; Yen S H
Widespread alterations of alpha-synuclein in multiple system atrophy.
The American journal of pathology 1999;155(4):1241-51.
1999: Prihar G; Verkkoniem A; Perez-Tur J; Crook R; Lincoln S; Houlden H; Somer M; Paetau A; Kalimo H; Grover A; Myllykangas L; Hutton M; Hardy J; Haltia M
Alzheimer disease PS-1 exon 9 deletion defined.
Nature medicine 1999;5(10):1090.
1999: Steiner H; Duff K; Capell A; Romig H; Grim M G; Lincoln S; Hardy J; Yu X; Picciano M; Fechteler K; Citron M; Kopan R; Pesold B; Keck S; Baader M; Tomita T; Iwatsubo T; Baumeister R; Haass C
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: Froelich S; Houlden H; Rizzu P; Chakraverty S; Baker M; Kwon J; Nowotny P; Isaacs A; Nowotny V; Wauters E; van Baren M J; Oostra B A; Hardy J; Lannfelt L; Goate A; Hutton M; Lendon C L; Heutink P
Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21.
Genomics 1999;60(2):129-36.
1999: Myllykangas L; Polvikoski T; Sulkava R; Verkkoniemi A; Crook R; Tienari P J; Pusa A K; Niinistö L; O'Brien P; Kontula K; Hardy J; Haltia M; Pérez-Tur J
Genetic association of alpha2-macroglobulin with Alzheimer's disease in a Finnish elderly population.
Annals of neurology 1999;46(3):382-90.
1999: Hardy J
Pathways to primary neurodegenerative disease.
Mayo Clinic proceedings. Mayo Clinic 1999;74(8):835-7.
1999: De Jonghe C; Cruts M; Rogaeva E A; Tysoe C; Singleton A; Vanderstichele H; Meschino W; Dermaut B; Vanderhoeven I; Backhovens H; Vanmechelen E; Morris C M; Hardy J; Rubinsztein D C; St George-Hyslop P H; Van Broeckhoven C
Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.
Human molecular genetics 1999;8(8):1529-40.
1999: Harhangi B S; Farrer M J; Lincoln S; Bonifati V; Meco G; De Michele G; Brice A; Dürr A; Martinez M; Gasser T; Bereznai B; Vaughan J R; Wood N W; Hardy J; Oostra B A; Breteler M M
The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease.
Neuroscience letters 1999;270(1):1-4.
1999: Lincoln S; Crook R; Chartier-Harlin M C; Gwinn-Hardy K; Baker M; Mouroux V; Richard F; Becquet E; Amouyel P; Destée A; Hardy J; Farrer M
No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.
Neuroscience letters 1999;269(2):107-9.
1999: Wavrant-De Vrièze F; Crook R; Holmans P; Kehoe P; Owen M J; Williams J; Roehl K; Laliiri D K; Shears S; Booth J; Wu W; Goate A; Chartier-Harlin M C; Hardy J; Pérez-Tur J
Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease.
Neuroscience letters 1999;269(2):67-70.
1999: Pérez-Tur J; Buée L; Morris H R; Waring S C; Onstead L; Wavrant-De Vrièze F; Crook R; Buée-Scherrer V; Hof P R; Petersen R C; McGeer P L; Delacourte A; Hutton M; Siddique T; Ahlskog J E; Hardy J; Steele J C
Neurodegenerative diseases of Guam: analysis of TAU.
Neurology 1999;53(2):411-3.
1999: Ostrerova N; Petrucelli L; Farrer M; Mehta N; Choi P; Hardy J; Wolozin B
alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(14):5782-91.
1999: Wavrant-DeVrièze F; Lambert J C; Stas L; Crook R; Cottel D; Pasquier F; Frigard B; Lambrechts M; Thiry E; Amouyel P; Tur J P; Chartier-Harlin M C; Hardy J; Van Leuven F
Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease.
Human genetics 1999;104(5):432-4.
1999: Prihar G; Gonzalez de Chavez F; Baker M; Crook R; McGowan E; Grover A; Hardy J; Hutton M
A novel candidate presenilin-1 interacting protein containing tetratricopeptide repeats.
Neuroreport 1999;10(7):1409-15.
1999: Gwinn-Hardy K; Evidente V G; Waters C; Muenter M D; Hardy J
L-dopa slows the progression of familial parkinsonism.
Lancet 1999;353(9167):1850-1.
1999: Rudrasingham V; Wavrant-De Vrièze F; Lambert J C; Chakraverty S; Kehoe P; Crook R; Amouyel P; Wu W; Rice F; Pérez-Tur J; Frigard B; Morris J C; Carty S; Petersen R; Cottel D; Tunstall N; Holmans P; Lovestone S; Chartier-Harlin M C; Goate A; Hardy J; Owen M J; Williams J
Alpha-2 macroglobulin gene and Alzheimer disease.
Nature genetics 1999;22(1):17-9; author reply 21-2.
1999: Hardy J; Israël A
Alzheimer's disease. In search of gamma-secretase.
Nature 1999;398(6727):466-7.
1999: Baker M; Litvan I; Houlden H; Adamson J; Dickson D; Perez-Tur J; Hardy J; Lynch T; Bigio E; Hutton M
Association of an extended haplotype in the tau gene with progressive supranuclear palsy.
Human molecular genetics 1999;8(4):711-5.
1999: Kamboh M I; Aston C E; Perez-Tur J; Kokmen E; Ferrell R E; Hardy J; DeKosky S T
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease.
Neuroscience letters 1999;263(2-3):129-32.
1999: Wavrant-DeVrièze F; Rudrasingham V; Lambert J C; Chakraverty S; Kehoe P; Crook R; Amouyel P; Wu W; Holmans P; Rice F; Pérez-Tur J; Frigard B; Morris J C; Carty S; Cottel D; Tunstall N; Lovestone S; Petersen R C; Chartier-Harlin M C; Goate A; Owen M J; Williams J; Hardy J
No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
Neuroscience letters 1999;262(2):137-9.
1999: Lincoln S; Vaughan J; Wood N; Baker M; Adamson J; Gwinn-Hardy K; Lynch T; Hardy J; Farrer M
Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease.
Neuroreport 1999;10(2):427-9.
1999: Houlden H; Rizzu P; Stevens M; de Knijff P; van Duijn C M; van Swieten J C; Heutink P; Perez-Tur J; Thomas V; Baker M; Morris H; Rossor M; Jannsen J C; Petersen R C; Dodd P; Dark F; Boeve B; Dickson D; Davies P; Pickering-Brown S; Mann D; Adamson J; Lynch T; Payami H; Hardy J
Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations.
Neuroscience letters 1999;260(3):193-5.
1999: Morris H R; Perez-Tur J; Janssen J C; Brown J; Lees A J; Wood N W; Hardy J; Hutton M; Rossor M N
Mutation in the tau exon 10 splice site region in familial frontotemporal dementia.
Annals of neurology 1999;45(2):270-1.
1999: Kehoe P; Wavrant-De Vrieze F; Crook R; Wu W S; Holmans P; Fenton I; Spurlock G; Norton N; Williams H; Williams N; Lovestone S; Perez-Tur J; Hutton M; Chartier-Harlin M C; Shears S; Roehl K; Booth J; Van Voorst W; Ramic D; Williams J; Goate A; Hardy J; Owen M J
A full genome scan for late onset Alzheimer's disease.
Human molecular genetics 1999;8(2):237-45.
1999: Hardy J
The shorter amyloid cascade hypothesis.
Neurobiology of aging 1999;20(1):85; discussion 87.
1999: Lincoln S; Gwinn-Hardy K; Goudreau J; Chartier-Harlin M C; Baker M; Mouroux V; Richard F; Destée A; Becquet E; Amouyel P; Lynch T; Hardy J; Farrer M
No pathogenic mutations in the persyn gene in Parkinson's disease.
Neuroscience letters 1999;259(1):65-6.
1999: Farrer M; Gwinn-Hardy K; Muenter M; DeVrieze F W; Crook R; Perez-Tur J; Lincoln S; Maraganore D; Adler C; Newman S; MacElwee K; McCarthy P; Miller C; Waters C; Hardy J
A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor.
Human molecular genetics 1999;8(1):81-5.
1999: Farrer M; Gwinn-Hardy K; Hutton M; Hardy J
The genetics of disorders with synuclein pathology and parkinsonism.
Human molecular genetics 1999;8(10):1901-5.
1998: Hardy J; Gwinn-Hardy K
Genetic classification of primary neurodegenerative disease.
Science (New York, N.Y.) 1998;282(5391):1075-9.
1998: Grünberg J; Walter J; Eckman C; Capell A; Schindzielorz A; Younkin S; Mehta N; Hardy J; Haass C
Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40.
Neuroreport 1998;9(14):3293-9.
1998: Hardy J; Duff K; Hardy K G; Perez-Tur J; Hutton M
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.
Nature neuroscience 1998;1(5):355-8.
1998: Lambert J C; Berr C; Pasquier F; Delacourte A; Frigard B; Cottel D; Pérez-Tur J; Mouroux V; Mohr M; Cécyre D; Galasko D; Lendon C; Poirier J; Hardy J; Mann D; Amouyel P; Chartier-Harlin M C
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.
Human molecular genetics 1998;7(9):1511-6.
1998: Wu W S; Holmans P; Wavrant-DeVrièze F; Shears S; Kehoe P; Crook R; Booth J; Williams N; Pérez-Tur J; Roehl K; Fenton I; Chartier-Harlin M C; Lovestone S; Williams J; Hutton M; Hardy J; Owen M J; Goate A
Genetic studies on chromosome 12 in late-onset Alzheimer disease.
JAMA : the journal of the American Medical Association 1998;280(7):619-22.
1998: Hutton M; Lendon C L; Rizzu P; Baker M; Froelich S; Houlden H; Pickering-Brown S; Chakraverty S; Isaacs A; Grover A; Hackett J; Adamson J; Lincoln S; Dickson D; Davies P; Petersen R C; Stevens M; de Graaff E; Wauters E; van Baren J; Hillebrand M; Joosse M; Kwon J M; Nowotny P; Che L K; Norton J; Morris J C; Reed L A; Trojanowski J; Basun H; Lannfelt L; Neystat M; Fahn S; Dark F; Tannenberg T; Dodd P R; Hayward N; Kwok J B; Schofield P R; Andreadis A; Snowden J; Craufurd D; Neary D; Owen F; Oostra B A; Hardy J; Goate A; van Swieten J; Mann D; Lynch T; Heutink P
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.
Nature 1998;393(6686):702-5.
1998: Crook R; Verkkoniemi A; Perez-Tur J; Mehta N; Baker M; Houlden H; Farrer M; Hutton M; Lincoln S; Hardy J; Gwinn K; Somer M; Paetau A; Kalimo H; Ylikoski R; Pöyhönen M; Kucera S; Haltia M
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.
Nature medicine 1998;4(4):452-5.
1998: Vaughan J R; Farrer M J; Wszolek Z K; Gasser T; Durr A; Agid Y; Bonifati V; DeMichele G; Volpe G; Lincoln S; Breteler M; Meco G; Brice A; Marsden C D; Hardy J; Wood N W
Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. The European Consortium on Genetic Susceptibility in Parkinson's Disease (GSPD).
Human molecular genetics 1998;7(4):751-3.
1998: Hardy J; Pérez-Tur J; Baker M; Farrer M; Crook R; Hutton M; Johnson W G; Gwinn K; Muenter M; Rocca W A; Maraganore D
Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with Lewy body parkinsonism.
American journal of medical genetics 1998;81(2):166-71.
1998: Farrer M; Wavrant-De Vrieze F; Crook R; Boles L; Perez-Tur J; Hardy J; Johnson W G; Steele J; Maraganore D; Gwinn K; Lynch T
Low frequency of alpha-synuclein mutations in familial Parkinson's disease.
Annals of neurology 1998;43(3):394-7.
1998: Houlden H; Crook R; Backhovens H; Prihar G; Baker M; Hutton M; Rossor M; Martin J J; Van Broeckhoven C; Hardy J
ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.
American journal of medical genetics 1998;81(1):117-21.
1998: Mehta N D; Refolo L M; Eckman C; Sanders S; Yager D; Perez-Tur J; Younkin S; Duff K; Hardy J; Hutton M
Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.
Annals of neurology 1998;43(2):256-8.
1998: Hardy J
The anatomy of tremor.
Journal of neurosurgery 1998;88(2):353-4.
1998: Harvey R J; Ellison D; Hardy J; Hutton M; Roques P K; Collinge J; Fox N C; Rossor M N
Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.
Journal of neurology, neurosurgery, and psychiatry 1998;64(1):44-9.
1998: Holcomb L; Gordon M N; McGowan E; Yu X; Benkovic S; Jantzen P; Wright K; Saad I; Mueller R; Morgan D; Sanders S; Zehr C; O'Campo K; Hardy J; Prada C M; Eckman C; Younkin S; Hsiao K; Duff K
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
Nature medicine 1998;4(1):97-100.
1998: Cruts M; van Duijn C M; Backhovens H; Van den Broeck M; Wehnert A; Serneels S; Sherrington R; Hutton M; Hardy J; St George-Hyslop P H; Hofman A; Van Broeckhoven C
Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.
Human molecular genetics 1998;7(1):43-51.
1998: Hutton M; Pérez-Tur J; Hardy J
Genetics of Alzheimer's disease.
Essays in biochemistry 1998;33():117-31.
1997: Lynch T; Farrer M; Hutton M; Hardy J
Genetics of Parkinson's disease.
Science (New York, N.Y.) 1997;278(5341):1212-3.
1997: Baker M; Kwok J B; Kucera S; Crook R; Farrer M; Houlden H; Isaacs A; Lincoln S; Onstead L; Hardy J; Wittenberg L; Dodd P; Webb S; Hayward N; Tannenberg T; Andreadis A; Hallupp M; Schofield P; Dark F; Hutton M
Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22.
Annals of neurology 1997;42(5):794-8.
1997: Lambert J C; Pérez-Tur J; Dupire M J; Galasko D; Mann D; Amouyel P; Hardy J; Delacourte A; Chartier-Harlin M C
Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.
Human molecular genetics 1997;6(12):2151-4.
1997: Eckman C B; Mehta N D; Crook R; Perez-tur J; Prihar G; Pfeiffer E; Graff-Radford N; Hinder P; Yager D; Zenk B; Refolo L M; Prada C M; Younkin S G; Hutton M; Hardy J
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
Human molecular genetics 1997;6(12):2087-9.
1997: Crook R; Ellis R; Shanks M; Thal L J; Perez-Tur J; Baker M; Hutton M; Haltia T; Hardy J; Galasko D
Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation.
Annals of neurology 1997;42(1):124-8.
1997: Winblad B; Hardy J
European research on Alzheimer's disease.
Lancet 1997;350(9070):73-4.
1997: Wavrant-DeVrièze F; Pérez-Tur J; Lambert J C; Frigard B; Pasquier F; Delacourte A; Amouyel P; Hardy J; Chartier-Harlin M C
Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.
Neuroscience letters 1997;227(1):68-70.
1997: Kwok J B; Taddei K; Hallupp M; Fisher C; Brooks W S; Broe G A; Hardy J; Fulham M J; Nicholson G A; Stell R; St George Hyslop P H; Fraser P E; Kakulas B; Clarnette R; Relkin N; Gandy S E; Schofield P R; Martins R N
Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.
Neuroreport 1997;8(6):1537-42.
1997: Hardy J
Amyloid, the presenilins and Alzheimer's disease.
Trends in neurosciences 1997;20(4):154-9.
1997: Fox N C; Kennedy A M; Harvey R J; Lantos P L; Roques P K; Collinge J; Hardy J; Hutton M; Stevens J M; Warrington E K; Rossor M N
Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor.
Brain : a journal of neurology 1997;120 ( Pt 3)():491-501.
1997: Hardy J
The Alzheimer family of diseases: many etiologies, one pathogenesis?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2095-7.
1997: Hutton M; Hardy J
The presenilins and Alzheimer's disease.
Human molecular genetics 1997;6(10):1639-46.
1996: Ward R V; Davis J B; Gray C W; Barton A J; Bresciani L G; Caivano M; Murphy V F; Duff K; Hutton M; Hardy J; Roberts G W; Karran E H
Presenilin-1 is processed into two major cleavage products in neuronal cell lines.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(4):293-8.
1996: Duff K; Eckman C; Zehr C; Yu X; Prada C M; Perez-tur J; Hutton M; Buee L; Harigaya Y; Yager D; Morgan D; Gordon M N; Holcomb L; Refolo L; Zenk B; Hardy J; Younkin S
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Nature 1996;383(6602):710-3.
1996: Barton A J; Crook B W; Karran E H; Brown F; Dewar D; Mann D M; Pearson R C; Graham D I; Hardy J; Hutton M; Duff K; Goate A M; Clark R F; Roberts G W
Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):213-8.
1996: Perez-Tur J; Croxton R; Wright K; Phillips H; Zehr C; Crook R; Hutton M; Hardy J; Karran E; Roberts G W; Lancaster S; Haltia T
A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):207-12.
1996: Mann D M; Iwatsubo T; Cairns N J; Lantos P L; Nochlin D; Sumi S M; Bird T D; Poorkaj P; Hardy J; Hutton M; Prihar G; Crook R; Rossor M N; Haltia M
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).
Annals of neurology 1996;40(2):149-56.
1996: Scheuner D; Eckman C; Jensen M; Song X; Citron M; Suzuki N; Bird T D; Hardy J; Hutton M; Kukull W; Larson E; Levy-Lahad E; Viitanen M; Peskind E; Poorkaj P; Schellenberg G; Tanzi R; Wasco W; Lannfelt L; Selkoe D; Younkin S
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Prihar G; Fuldner R A; Perez-Tur J; Lincoln S; Duff K; Crook R; Hardy J; Philips C A; Venter C; Talbot C; Clark R F; Goate A; Li J; Potter H; Karran E; Roberts G W; Hutton M; Adams M D
Structure and alternative splicing of the presenilin-2 gene.
Neuroreport 1996;7(10):1680-4.
1996: Thinakaran G; Borchelt D R; Lee M K; Slunt H H; Spitzer L; Kim G; Ratovitsky T; Davenport F; Nordstedt C; Seeger M; Hardy J; Levey A I; Gandy S E; Jenkins N A; Copeland N G; Price D L; Sisodia S S
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Neuron 1996;17(1):181-90.
1996: Hardy J
New insights into the genetics of Alzheimer's disease.
Annals of medicine 1996;28(3):255-8.
1996: Talbot C; Houlden H; Craddock N; Crook R; Hutton M; Lendon C; Prihar G; Morris J C; Hardy J; Goate A
Polymorphism in AACT gene may lower age of onset of Alzheimer's disease.
Neuroreport 1996;7(2):534-6.
1996: Royston M C; Mann D; Pickering-Brown S; Owen F; Perry R; Ragbavan R; Khin-Nu C; Tyner S; Day K; Crook R; Hardy J; Roberts G W
ApoE2 allele, Down's syndrome, and dementia.
Annals of the New York Academy of Sciences 1996;777():255-9.
1996: Clark R F; Hutton M; Talbot C; Wragg M; Lendon C; Busfield F; Han S W; Perez-Tur J; Adams M; Fuldner R; Roberts G; Karran E; Hardy J; Goate A
The role of presenilin 1 in the genetics of Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():551-8.
1996: Hardy J
Molecular genetics of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1996;165():13-7.
1995: Hardy J
Apolipoprotein E in the genetics and epidemiology of Alzheimer's disease.
American journal of medical genetics 1995;60(5):456-60.
1995: Hardy J; Hutton M
Two new genes for Alzheimer's disease.
Trends in neurosciences 1995;18(10):436.
1995: Brown J; Ashworth A; Gydesen S; Sorensen A; Rossor M; Hardy J; Collinge J
Familial non-specific dementia maps to chromosome 3.
Human molecular genetics 1995;4(9):1625-8.
1995: Ashworth A; Brown J; Gydesen S; Sorensen S A; Rossor M N; Hardy J; Collinge J
Frontal lobe or 'nonspecific' dementias are genetically heterogeneous.
Neurology 1995;45(9):1781.
1995: Houlden H; Crook R; Duff K; Hutton M; Collinge J; Roques P; Rossor M; Hardy J
Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
Neuroscience letters 1995;188(3):202-4.
1995: Duff K; Hardy J
Alzheimer's disease. Mouse model made.
Nature 1995;373(6514):476-7.
1995: Lannfelt L; Lilius L; Viitanen M; Houlden H; Rossor M; Hardy J; Winblad B; Basun H
Microsatellite D21S210 (GT-12) allele frequencies in sporadic Alzheimer's disease.
Acta neurologica Scandinavica 1995;91(2):145-8.
1995: Lippa C F; Smith T W; Saunders A M; Crook R; Pulaski-Salo D; Davies P; Hardy J; Roses A D; Dickson D
Apolipoprotein E genotype and Lewy body disease.
Neurology 1995;45(1):97-103.
1994: Hardy J; Crook R; Prihar G; Roberts G; Raghavan R; Perry R
Senile dementia of the Lewy body type has an apolipoprotein E epsilon 4 allele frequency intermediate between controls and Alzheimer's disease.
Neuroscience letters 1994;182(1):1-2.
1994: Hardy J
Alzheimer's disease. Molecular genetics.
The Journal of the Florida Medical Association 1994;81(11):759-61.
1994: Hardy J
Lewy bodies in Alzheimer's disease in which the primary lesion is a mutation in the amyloid precursor protein.
Neuroscience letters 1994;180(2):290-1.
1994: Rempfer R; Crook R; Houlden H; Duff K; Hutton M; Roberts G W; Raghavan R; Perry R; Hardy J
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Lancet 1994;344(8925):815.
1994: Crook R; Hardy J; Duff K
Single-day apolipoprotein E genotyping.
Journal of neuroscience methods 1994;53(2):125-7.
1994: Collinge J; Palmer M S; Sidle K C; Mahal S P; Campbell T; Brown J; Hardy J; Brun A E; Gustafson L; Bakker E
Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease.
Journal of neurology, neurosurgery, and psychiatry 1994;57(6):762.
1994: Houlden H; Crook R; Hardy J; Roques P; Collinge J; Rossor M
Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus.
Neuroscience letters 1994;174(2):222-4.
1994: Hardy J
Alzheimer's disease. Clinical molecular genetics.
Clinics in geriatric medicine 1994;10(2):239-47.
1994: Hardy J; Crook R; Perry R; Raghavan R; Roberts G
ApoE genotype and Down's syndrome.
Lancet 1994;343(8903):979-80.
1994: Van Broeckhoven C; Backhovens H; Cruts M; Martin J J; Crook R; Houlden H; Hardy J
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.
Neuroscience letters 1994;169(1-2):179-80.
1994: Lannfelt L; Bogdanovic N; Appelgren H; Axelman K; Lilius L; Hansson G; Schenk D; Hardy J; Winblad B
Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.
Neuroscience letters 1994;168(1-2):254-6.
1994: Hardy J
ApoE, amyloid, and Alzheimer's disease.
Science (New York, N.Y.) 1994;263(5146):454-5.
1994: Duff K; McGuigan A; Huxley C; Schulz F; Hardy J
Insertion of a pathogenic mutation into a yeast artificial chromosome containing the human amyloid precursor protein gene.
Gene therapy 1994;1(1):70-5.
1994: Hardy J
Alzheimer's disease: the present situation and our tasks.
Neurobiology of aging 1994;15 Suppl 2():S111-2.
1993: Rooke K; Talbot C; James L; Anand R; Hardy J A; Goate A M
A physical map of the human APP gene in YACs.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(11):662-9.
1993: Lannfelt L; Folkesson R; Mohammed A H; Winblad B; Hellgren D; Duff K; Hardy J
Alzheimer's disease: molecular genetics and transgenic animal models.
Behavioural brain research 1993;57(2):207-13.
1993: Hardy J; Roberts G W
Smoking and neurogenerative diseases.
Lancet 1993;342(8881):1238.
1993: Hardy J; Duff K
Heterogeneity in Alzheimer's disease.
Annals of medicine 1993;25(5):437-40.
1993: King A; Houlden H; Hardy J; Lane R; Chancellor A; de Belleroche J
Absence of linkage between chromosome 21 loci and familial amyotrophic lateral sclerosis.
Journal of medical genetics 1993;30(4):318.
1993: Kennedy A M; Newman S; McCaddon A; Ball J; Roques P; Mullan M; Hardy J; Chartier-Harlin M C; Frackowiak R S; Warrington E K
Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).
Brain : a journal of neurology 1993;116 ( Pt 2)():309-24.
1993: Hardy J
"Prion dementia".
Lancet 1993;341(8845):626-7; author reply 627-8.
1993: Adroer R; Lopez-Acedo C; Oliva R; Hardy J; Fidani L
A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and control cases.
Neuroscience letters 1993;150(1):33-4.
1993: Harlin M C; Crawford F; Perl D P; Steele J; Hardy J
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene reveals the beta-amyloid sequence to be normal in cases of the parkinson dementia complex of Guam.
Journal of neural transmission. Parkinson's disease and dementia section 1993;5(1):63-5.
1992: Mullan M; Houlden H; Windelspecht M; Fidani L; Lombardi C; Diaz P; Rossor M; Crook R; Hardy J; Duff K
A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.
Nature genetics 1992;2(4):340-2.
1992: Hardy J; Mullan M
Alzheimer's disease. In search of the soluble.
Nature 1992;359(6393):268-9.
1992: Hardy J
Framing beta-amyloid.
Nature genetics 1992;1(4):233-4.
1992: Hardy J
An 'anatomical cascade hypothesis' for Alzheimer's disease.
Trends in neurosciences 1992;15(6):200-1.
1992: Collinge J; Brown J; Hardy J; Mullan M; Rossor M N; Baker H; Crow T J; Lofthouse R; Poulter M; Ridley R
Inherited prion disease with 144 base pair gene insertion. 2. Clinical and pathological features.
Brain : a journal of neurology 1992;115 ( Pt 3)():687-710.
1992: Fidani L; Rooke K; Chartier-Harlin M C; Hughes D; Tanzi R; Mullan M; Roques P; Rossor M; Hardy J; Goate A
Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile.
Human molecular genetics 1992;1(3):165-8.
1992: Hardy J A; Higgins G A
Alzheimer's disease: the amyloid cascade hypothesis.
Science (New York, N.Y.) 1992;256(5054):184-5.
1992: Crawford F; Chartier-Harlin M C; Mullan M; Hardy J; Delacourte A; Arnott G
Alzheimer's--a correction.
Nature 1992;356(6368):390.
1992: Mann D M; Jones D; Snowden J S; Neary D; Hardy J
Pathological changes in the brain of a patient with familial Alzheimer's disease having a missense mutation at codon 717 in the amyloid precursor protein gene.
Neuroscience letters 1992;137(2):225-8.
1992: Hardy J; Chartier-Harlin M C; Mullan M
Alzheimer disease: the new agenda.
American journal of human genetics 1992;50(3):648-51.
1991: Crawford F; Hardy J; Mullan M; Goate A; Hughes D; Fidani L; Roques P; Rossor M; Chartier-Harlin M C
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence.
Neuroscience letters 1991;133(1):1-2.
1991: Chartier-Harlin M C; Crawford F; Houlden H; Warren A; Hughes D; Fidani L; Goate A; Rossor M; Roques P; Hardy J
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
Nature 1991;353(6347):844-6.
1991: Hardy J; Allsop D
Amyloid deposition as the central event in the aetiology of Alzheimer's disease.
Trends in pharmacological sciences 1991;12(10):383-8.
1991: Chartier-Harlin M C; Crawford F; Hamandi K; Mullan M; Goate A; Hardy J; Backhovens H; Martin J J; Broeckhoven C V
Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.
Neuroscience letters 1991;129(1):134-5.
1991: Pearson R C; Mullan M; Hardy J; Harrison P J
Nicotine intake and Alzheimer's disease.
BMJ (Clinical research ed.) 1991;303(6798):361.
1991: Owen M J; Goate A M; Hardy J A
A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80).
Nucleic acids research 1991;19(16):4574.
1991: Haan J; Hardy J A; Roos R A
Hereditary cerebral hemorrhage with amyloidosis--Dutch type: its importance for Alzheimer research.
Trends in neurosciences 1991;14(6):231-4.
1991: Owen F; Poulter M; Collinge J; Leach M; Shah T; Lofthouse R; Chen Y F; Crow T J; Harding A E; Hardy J
Insertions in the prion protein gene in atypical dementias.
Experimental neurology 1991;112(2):240-2.
1991: van Duijn C M; van Broeckhoven C; Hardy J A; Goate A M; Rossor M N; Vandenberghe A; Martin J J; Hofman A; Mullan M J
Evidence for allelic heterogeneity in familial early-onset Alzheimer's disease.
The British journal of psychiatry : the journal of mental science 1991;158():471-4.
1991: van Duijn C M; Hendriks L; Cruts M; Hardy J A; Hofman A; Van Broeckhoven C
Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.
Lancet 1991;337(8747):978.
1991: Irving N G; Hardy J A; Brown S D
The multipoint genetic mapping of mouse chromosome 16.
Genomics 1991;9(2):386-9.
1991: Brown J; Smith S; Brun A; Collinge J; Gydesen S; Hardy J; Mullan M; Goate A
Genetic characterization of a novel familial dementia.
Annals of the New York Academy of Sciences 1991;640():181-3.
1991: Mullan M J; Giuffra L; Hardy J A; Ovenstone I; Haynes A R; James L A; Williamson R; Newton P J; Owen M J; Roques P
Clinical and pathologic features of chromosome 21-linked familial Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():177-80.
1990: Barton A J; Harrison P J; Najlerahim A; Heffernan J; McDonald B; Robinson J R; Davies D C; Harrison W J; Mitra P; Hardy J A
Increased tau messenger RNA in Alzheimer's disease hippocampus.
The American journal of pathology 1990;137(3):497-502.
1990: Collinge J; Owen F; Poulter M; Leach M; Crow T J; Rossor M N; Hardy J; Mullan M J; Janota I; Lantos P L
Prion dementia without characteristic pathology.
Lancet 1990;336(8706):7-9.
1990: Cowburn R F; Hardy J A; Roberts P J
Glutamatergic neurotransmission in Alzheimer's disease.
Biochemical Society transactions 1990;18(3):390-2.
1990: Van Broeckhoven C; Haan J; Bakker E; Hardy J A; Van Hul W; Wehnert A; Vegter-Van der Vlis M; Roos R A
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).
Science (New York, N.Y.) 1990;248(4959):1120-2.
1990: Walker A P; Collins F S; Siddique T; Yamaoka L H; Herbstreith M H; Pericak-Vance M A; Secore S L; Hung W Y; Goate A M; Hardy J A
D21S194, a jump clone from D21S16.
Nucleic acids research 1990;18(7):1931.
1990: Wester P; Bergström U; Eriksson A; Gezelius C; Hardy J; Winblad B
Ventricular cerebrospinal fluid monoamine transmitter and metabolite concentrations reflect human brain neurochemistry in autopsy cases.
Journal of neurochemistry 1990;54(4):1148-56.
1990: Owen M J; James L A; Hardy J A; Williamson R; Goate A M
Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.
American journal of human genetics 1990;46(2):316-22.
1990: Goate A M; Hardy J A; Owen M J; Haynes A; James L; Farrall M; Mullan M J; Roques P; Rossor M N
Genetics of Alzheimer's disease.
Advances in neurology 1990;51():197-8.
1990: Hardy J
Molecular genetics of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1990;129():29-31.
1989: Bradford H F; Foley P; Docherty M; Fillit H; Luine V N; McEwen B; Bucht G; Winbald B; Hardy J
Antibodies in serum of patients with Alzheimer's disease cause immunolysis of cholinergic nerve terminals from the rat cerebral cortex.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1989;16(4 Suppl):528-34.
1989: Hardy J A; Goate A M; Owen M J; Mullan M J; Rossor M N; Pearson R C
Modelling the occurrence and pathology of Alzheimer's disease.
Neurobiology of aging 1989;10(5):429-31; discussion 446-8.
1989: Hardy J; Goate A; Owen M; Rossor M
Presenile dementia associated with mosaic trisomy 21 in a patient with a Down syndrome child.
Lancet 1989;2(8665):743.
1989: Dodd P R; Watson W E; Morrison M M; Johnston G A; Bird E D; Cowburn R F; Hardy J A
Uptake of gamma-aminobutyric acid and L-glutamic acid by synaptosomes from postmortem human cerebral cortex: multiple sites, sodium dependence and effect of tissue preparation.
Brain research 1989;490(2):320-31.
1989: Hardy J; Irving N; Kessling A
Down on chromosome 21?
Trends in neurosciences 1989;12(6):209-10.
1989: Willoughby J; Cowburn R F; Hardy J A; Glover V; Sandler M
1-Methyl-4-phenylpyridinium uptake by human and rat striatal synaptosomes.
Journal of neurochemistry 1989;52(2):627-31.
1989: Hardy J A; Owen M J; Goate A M; James L A; Haynes A R; Rossor M N; Roques P; Mullan M J
Molecular genetics of Alzheimer's disease.
Biochemical Society transactions 1989;17(1):75-6.
1989: Cowburn R F; Hardy J A; Briggs R S; Roberts P J
Characterisation, density, and distribution of kainate receptors in normal and Alzheimer's diseased human brain.
Journal of neurochemistry 1989;52(1):140-7.
1989: Irving N G; Hardy J A; Bahary N; Friedman J M; Brown S D
The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6.
Cytogenetics and cell genetics 1989;50(2-3):121-2.
1989: Nordberg A; Nilsson-Håkansson L; Adem A; Hardy J; Alafuzoff I; Lai Z; Herrera-Marschitz M; Winblad B
The role of nicotinic receptors in the pathophysiology of Alzheimer's disease.
Progress in brain research 1989;79():353-62.
1988: Foley P; Bradford H F; Docherty M; Fillit H; Luine V N; McEwen B; Bucht G; Winblad B; Hardy J
Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease.
Journal of neurology 1988;235(8):466-71.
1988: Hardy J
Molecular biology and Alzheimer's disease: more questions than answers.
Trends in neurosciences 1988;11(7):293-4.
1988: Bateman D E; Hardy J A; McDermott J R; Parker D S; Edwardson J A
Amino acid neurotransmitter levels in gliomas and their relationship to the incidence of epilepsy.
Neurological research 1988;10(2):112-4.
1988: Cowburn R; Hardy J; Roberts P; Briggs R
Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease.
Brain research 1988;452(1-2):403-7.
1988: Cowburn R F; Hardy J A; Roberts P J
Characterisation of Na+-independent L-[3H]glutamate binding sites in human temporal cortex.
Journal of neurochemistry 1988;50(6):1872-8.
1988: Hardy J A; Davies D C
Alzheimer's disease.
British journal of hospital medicine 1988;39(5):372-3, 376-7.
1988: Dodd P R; Hambley J W; Cowburn R F; Hardy J A
A comparison of methodologies for the study of functional transmitter neurochemistry in human brain.
Journal of neurochemistry 1988;50(5):1333-45.
1988: Nordberg A; Adem A; Hardy J; Winblad B
Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains.
Neuroscience letters 1988;86(3):317-21.
1988: O'Connor I; Cowburn R F; Hardy J A; Fowler C J
Dopamine and apomorphine do not modulate the uptake of [3H]D-aspartate in the rat striatum in-vitro.
The Journal of pharmacy and pharmacology 1988;40(4):307-8.
1988: Cowburn R; Hardy J; Roberts P; Briggs R
Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease.
Neuroscience letters 1988;86(1):109-13.
1988: Hardy J
Mouse models of human neurogenetic disorders.
Trends in neurosciences 1988;11(3):89-90.
1988: Davies D C; Hardy J A
Blood brain barrier in ageing and Alzheimer's disease.
Neurobiology of aging 1988;9(1):46-8.
1987: Turner J D; Boakes R J; Hardy J A; Virmani M A
Efflux of putative transmitters from superfused rat brain slices induced by low chloride ion concentrations.
Journal of neurochemistry 1987;48(4):1060-8.
1987: Hardy J; Cowburn R; Barton A; Reynolds G; Dodd P; Wester P; O'Carroll A M; Lofdahl E; Winblad B
A disorder of cortical GABAergic innervation in Alzheimer's disease.
Neuroscience letters 1987;73(2):192-6.
1987: Hardy J; Cowburn R; Barton A; Reynolds G; Lofdahl E; O'Carroll A M; Wester P; Winblad B
Region-specific loss of glutamate innervation in Alzheimer's disease.
Neuroscience letters 1987;73(1):77-80.
1987: Nilsson L; Adem A; Hardy J; Winblad B; Nordberg A
Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brains via nicotinic receptors?
Journal of neural transmission 1987;70(3-4):357-68.
1986: Venables G S; Strong A J; Miller S A; Gibson G; Hardy J A
The effects of etomidate in the cat middle cerebral artery occlusion model of brain ischaemia. An experimental study.
Neurological research 1986;8(4):209-13.
1986: Hardy J A; Mann D M; Wester P; Winblad B
An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease.
Neurobiology of aging 1986;7(6):489-502.
1986: Hardy J A; Barton A; Lofdahl E; Cheetham S C; Johnston G A; Dodd P R
Uptake of gamma-aminobutyric acid and glycine by synaptosomes from postmortem human brain.
Journal of neurochemistry 1986;47(2):460-7.
1986: Dodd P R; Hardy J A; Baig E B; Kidd A M; Bird E D; Watson W E; Johnston G A
Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain.
Neurochemical pathology 1986;4(3):177-98.
1986: Almqvist P; Carlsson S R; Hardy J A; Winblad B
Regional and subcellular distribution of Thy-1 in human brain assayed by a solid-phase radioimmunoassay.
Journal of neurochemistry 1986;46(3):681-5.
1986: Nilsson L; Nordberg A; Hardy J; Wester P; Winblad B
Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level.
Journal of neural transmission 1986;67(3-4):275-85.
1985: Venables G S; Miller S A; Gibson G; Hardy J A; Strong A J
The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat.
Journal of neurology, neurosurgery, and psychiatry 1985;48(7):663-9.
1985: Stenström A; Oreland L; Hardy J; Wester P; Winblad B
The uptake of serotonin and dopamine by homogenates of frozen rat and human brain tissue.
Neurochemical research 1985;10(5):591-9.
1985: Nyberg P; Adolfsson R; Hardy J A; Nordberg A; Wester P; Winblad B
Catecholamine topochemistry in human basal ganglia. Comparison between normal and Alzheimer brains.
Brain research 1985;333(1):139-42.
1985: Wester P; Bateman D E; Dodd P R; Edwardson J A; Hardy J A; Kidd A M; Perry R H; Singh G B
Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain.
Neurochemical pathology 1985;3(3):169-80.
1985: Hardy J A; Wester P; Winblad B; Gezelius C; Bring G; Eriksson A
The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue.
Journal of neural transmission 1985;61(3-4):253-64.
1985: Winblad B; Hardy J; Bäckman L; Nilsson L G
Memory function and brain biochemistry in normal aging and in senile dementia.
Annals of the New York Academy of Sciences 1985;444():255-68.
1984: Perry E K; Atack J R; Perry R H; Hardy J A; Dodd P R; Edwardson J A; Blessed G; Tomlinson B E; Fairbairn A F
Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal.
Journal of neurochemistry 1984;42(5):1402-10.
1984: Hardy J A; Boakes R J; Thomas D J; Kidd A M; Edwardson J A; Virmani M; Turner J; Dodd P R
Release of aspartate and glutamate caused by chloride reduction in synaptosomal incubation media.
Journal of neurochemistry 1984;42(3):875-7.
1984: Hardy J A; Bateman D E; Kidd A M; Edwardson J A; Singh G B; Dodd P R
Amino acid transport by synaptosomes isolated from post mortem human brain.
Journal of neural transmission 1984;60(1):57-62.
1984: Wester P; Hardy J A; Marcusson J; Nyberg P; Winblad B
Serotonin concentrations in normal aging human brains: relation to serotonin receptors.
Neurobiology of aging 1984;5(3):199-203.
1983: Hardy J A; Dodd P R; Oakley A E; Perry R H; Edwardson J A; Kidd A M
Metabolically active synaptosomes can be prepared from frozen rat and human brain.
Journal of neurochemistry 1983;40(3):608-14.
1983: Strong A J; Tomlinson B E; Venables G S; Gibson G; Hardy J A
The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 2. Studies of histopathology, water content, and in vitro neurotransmitter uptake.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1983;3(1):97-108.
1983: McDermott J R; Smith A I; Dodd P R; Hardy J A; Edwardson J A
Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases.
Peptides 1983;4(1):25-30.
1982: Hardy J A; Dodd P R; Oakley A E; Kidd A M; Perry R H; Edwardson J A
Use of post-mortem human synaptosomes for studies of metabolism and transmitter amino acid release.
Neuroscience letters 1982;33(3):317-22.
1981: Dodd P R; Hardy J A; Oakley A E; Edwardson J A; Perry E K; Delaunoy J P
A rapid method for preparing synaptosomes: comparison, with alternative procedures.
Brain research 1981;226(1-2):107-18.
1981: Dodd P; Hardy J A; Oakley A E; Strong A J
Synaptosomes prepared from fresh human cerebral cortex; morphology, respiration and release of transmitter amino acids.
Brain research 1981;224(2):419-25.
1980: Reynolds G P; Sandler M; Hardy J; Bradford H
The determination and distribution of 2-phenylethylamine in sheep brain.
Journal of neurochemistry 1980;34(5):1123-5.
1980: Hardy J A; de Belleroche J S; Border D; Bradford H F
Differential transmitter release from nerve terminals isolated from basal ganglia and substantia nigra.
Journal of neurochemistry 1980;34(5):1130-9.
1980: Somma M; Rasio E; Beauregard H; Hardy J
[Pituitary adenomas. Surgical treatment by transphenoidal approach]
L'unión médicale du Canada 1980;109(1):68-81.
1979: Dodd P R; Hardy J A; Bradford H F; Bennett G W; Edwardson J A; Harding B N
Metabolic and secretory processes in nerve-endings isolated from post-mortem brain.
Neuroscience letters 1979;11(1):87-92.
1975: Molina-Negro P; Hardy J
Semiology of Tremors.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1975;2(1):23-9.
1972: Velasco F C; Molina-Negro P; Bertrand C; Hardy J
Further definition of the subthalamic target for arrest of tremor.
Journal of neurosurgery 1972;36(2):184-91.
1971: Molina-Negro P; Hardy J
[Semeiological study of trembling]
L'unión médicale du Canada 1971;100(5):879-95.
1970: Papeschi R; Molina-Negro P; Sourkes T L; Hardy J; Bertrand C
Concentration of homovanillic acid in the ventricular fluid of patients with Parkinson's disease and other dyskinesias.
Neurology 1970;20(10):991-5.
1970: Papeschi R; Molina-Negro P; Sourkes T L; Hardy J; Bertrand C
Homovanillic acid in the ventricular fluid of patients with Parkinson's disease and other extrapyramidal diseases.
Laval médical 1970;41(7):899-901.
1970: Hardy J; Molina-Negro P; Bertrand C; Martinez N S
[Tremor of attitude: physiopathologic study]
L'unión médicale du Canada 1970;99(3):449-56.
1969: Bertrand C; Hardy J; Molina-Negro P; Martinez S N
Tremor of attitude.
Confinia neurologica 1969;31(1):37-41.
1965: Hardy J; Bertrand C
Electrophysiological exploration of sub-cortical structures with microelectrode during stereotaxic surgery.
Confinia neurologica 1965;26(3):201-4.
1962: GUIOT G; HARDY J; ALBE-FESSARD D
[Precise delimitation of the subcortical structures and identification of thalamic nuclei in man by stereotactic electrophysiology.]
Neurochirurgia 1962;5():1-18.
1961: HARDY J
[Neurophysiological mechanisms of parkinsonian tremor.]
L'unión médicale du Canada 1961;90():131-47.
1961: BARBEAU A; GIGUERE R; HARDY J
[Clinical experience with tolbutamide in Parkinson's disease.]
L'unión médicale du Canada 1961;90():147-51.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

John Hardy

Research Profile (preview)

Disorders

Physiology

Chemicals & Drugs

Anatomy

Concepts & Ideas

Genes & Molecular Sequences

Procedures

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of John Hardy (preview)

All Publications