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John Hardy

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Helen Crehan; John Hardy; Jennifer Pocock
Blockage of CR1 prevents activation of rodent microglia.
Aoife P Kiely; Andrew J Lees; Patrick Lewis; Patricia Limousin; Helen Ling; christos proukakis; Niall Quinn; Tamas Revesz; Yasmine T Asi; John Hardy; Henry Houlden; Eleanna Kara; Janice L Holton
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
Fernando Bartolome; Victoria S Burchell; Andrea Calvo; Antonio Canosa; Adriano Chio; Nick C Fox; John Hardy; Henry Houlden; Colin J Mahoney; Jessica Mandrioli; Cristina Moglia; Richard W Orrell; Elisavet Preza; Selina Wray; Hsiu-Chuan Wu; Andrey Y Abramov; Hélène Plun-Favreau
Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels.

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All Publications

2013: Helen Crehan; John Hardy; Jennifer Pocock
Blockage of CR1 prevents activation of rodent microglia.
Neurobiology of disease 2013;54():139-49.
2013: Aoife P Kiely; Andrew J Lees; Patrick Lewis; Patricia Limousin; Helen Ling; christos proukakis; Niall Quinn; Tamas Revesz; Yasmine T Asi; John Hardy; Henry Houlden; Eleanna Kara; Janice L Holton
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
Acta neuropathologica 2013;125(5):753-69.
2013: Fernando Bartolome; Victoria S Burchell; Andrea Calvo; Antonio Canosa; Adriano Chio; Nick C Fox; John Hardy; Henry Houlden; Colin J Mahoney; Jessica Mandrioli; Cristina Moglia; Richard W Orrell; Elisavet Preza; Selina Wray; Hsiu-Chuan Wu; Andrey Y Abramov; Hélène Plun-Favreau
Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels.
Neuron 2013;78(1):57-64.
2013: John Hardy
Reply to Letter: Identical twins with leucine rich repeat kinase type 2 mutations discordant for Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2013;28(4):561-2.
2013: Azad Kumar; Ravindran Kumaran; Mina Ryten; Andrew B Singleton; Colin Smith; Daniah Trabzuni; Bryan Joseph Traynor; Robert Walker; Alexandra Beilina; Allissa Dillman; J Raphael Gibbs; John Hardy; Mark Cookson
Age-associated changes in gene expression in human brain and isolated neurons.
Neurobiology of aging 2013;34(4):1199-209.
2013: Patrick Holton; Matthew J Huentelman; Richard Mayeux; Amanda Myers; Michael Nalls; Margaret A Pericak-Vance; Manuel Ramirez-Restrepo; Eric M Reiman; Mina Ryten; Gerard D Schellenberg; Andrew Singleton; Daniah Trabzuni; Michael E Weale; Liana G Apostolova; Steven E Arnold; Clinton T Baldwin; Robert Barber; Michael M Barmada; Thomas G Beach; Gary W Beecham; Duane Beekly; David A Bennett; Eileen H Bigio; Thomas D Bird; Deborah Blacker; Bradley F Boeve; James D Bowen; Adam Boxer; James R Burke; Jacqueline Buros; Joseph D Buxbaum; Nigel J Cairns; Laura B Cantwell; Chuanhai Cao; Chris S Carlson; Regina M Carney; Minerva M Carrasquillo; Steven L Carroll; Helena C Chui; David G Clark; Carl W Cotman; Paul K Crane; Elizabeth A Crocco; Carlos Cruchaga; Jeffrey L Cummings; Philip L De Jager; Charles DeCarli; Steven T DeKosky; F Yesim Demirci; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; Ranjan Duara; William G Ellis; Nilufer Ertekin-Taner; Denis Evans; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Tatiana M Foroud; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; Alison M Goate; Neill R Graff-Radford; Robert C Green; John H Growdon; Hakon Hakonarson; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gail P Jarvik; Gregory A Jicha; Lee-Way Jin; Gyungah Jun; M Ilyas Kamboh; Jason Karlawish; Anna Karydas; John S K Kauwe; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; Patricia Kramer; Walter A Kukull; James J Lah; Eric B Larson; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Kathryn L Lunetta; Wendy J Mack; Daniel C Marson; Eden R Martin; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Thomas J Montine; John C Morris; Adam C Naj; Petra Nowotny; Joseph E Parisi; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Huntington Potter; Joseph F Quinn; Ashok Raj; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; Christiane Reitz; John M Ringman; Erik D Roberson; Ekaterina Rogaeva; Roger N Rosenberg; Mary Sano; Andrew J Saykin; Julie A Schneider; Lon S Schneider; William W Seeley; Michael L Shelanski; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Peter St George-Hyslop; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Debby W Tsuang; Otto Valladares; Vivianna M Van Deerlin; Badri N Vardarajan; Harry V Vinters; Jean Paul Vonsattel; Li-San Wang; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Clinton B Wright; Mark R Cookson; Jason J Corneveaux; Helen Crehan; Allissa Dillman; Anzhelika Engel; Lindsay A Farrer; J Raphael Gibbs; Rita Guerreiro; Jonathan L Haines; John Hardy; Dena Hernandez; Steven G Younkin
Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
Annals of human genetics 2013;77(2):85-105.
2013: Georgia Xiromerisiou; Efthimios Dardiotis; Georgios Hadjigeorgiou; John Hardy; Eleanna Kara; Antonios Petalas; Styliani Ralli; Sophia Tachmitzi; Evangelia E Tsironi; Henry Houlden
THAP1 mutations in a Greek primary blepharospasm series.
Parkinsonism & related disorders 2013;19(3):404-5.
2013: Tammaryn Lashley; John Hardy; Adrian M Isaacs
RANTing about C9orf72.
Neuron 2013;77(4):597-8.
2013: Raquel Duran; Aikaterini V Angeli; Kailash P Bhatia; Timothy M Cox; Emma Deas; Patrick Deegan; John Hardy; Henry Houlden; derralynn hughes; Paul R Jarman; Andrew J Lees; Patricia Limousin; Atul Mehta; Niccolo E Mencacci; Anthony H Schapira; Maryam Shoai; Nicholas W Wood; Tom Foltynie
The glucocerobrosidase E326K variant predisposes to Parkinson's disease, but does not cause Gaucher's disease.
Movement disorders : official journal of the Movement Disorder Society 2013;28(2):232-6.
2013: Rita Guerreiro; John Hardy; Lilinaz Hazrati; John S K Kauwe; Jean-Charles Lambert; Tammaryn Lashley; Elisa Majounie; Kevin Morgan; Jennifer Pocock; John Powell; Rosa Rademakers; Ekaterina Rogaeva; Celeste Sassi; Andrew Singleton; Peter St George-Hyslop; Julie Williams; Aleksandra Wojtas; Steven Younkin; Philippe Amouyel; Jose Bras; Minerva Carrasquillo; John Collinge; Carlos Cruchaga; Alison Goate
TREM2 variants in Alzheimer's disease.
The New England journal of medicine 2013;368(2):117-27.
2013: Rachael I Scahill; Jonathan M Schott; Jason D Warren; Josephine Barnes; Jonathan W Bartlett; Jonathan Beck; Matthew J Clarkson; Sebastian J Crutch; John Hardy; Simon Mead; Sébastien Ourselin; Gerard R Ridgway; Martin N Rossor; Natalie S Ryan; Nick C Fox
Genetic influences on atrophy patterns in familial Alzheimer's Disease: a comparison of APP and PSEN1 mutations.
Journal of Alzheimer's disease : JAD 2013;35(1):199-212.
2013: Michael W J Cleeter; Michael Duchen; Caroline Gluck; John Hardy; Derralynn A Hughes; J Mark Cooper; Atul Mehta; Kai-Yin Chau; Nicholas William Wood; Anthony Henry Schapira
Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage.
Neurochemistry international 2013;62(1):1-7.
2012: Maja Kojovic; Rodger Palmer; Ignacio Rubio-Agusti; Anirban Saha; Una-Marie Sheerin; Nicholas W Wood; Jose Bras; Vaneesha Gibbons; John Hardy; Henry Houlden; Kailash P Bhatia
Young-onset parkinsonism due to homozygous duplication of α-synuclein in a consanguineous family.
Movement disorders : official journal of the Movement Disorder Society 2012;27(14):1827-9.
2012: Florian Mittag; Mike A Nalls; Mohamad Saad; Claudia Schulte; Manu Sharma; Javier Simón-Sánchez; Andrew B Singleton; Nicholas W Wood; Andreas Zell; Zoltan Bochdanovits; Alexis Brice; Finja Büchel; Thomas Gasser; J Raphael Gibbs; John Hardy; Dena G Hernandez; Peter Heutink; Andreas Jahn; Margaux Keller; Suzanne Lesage; Maria Martinez
Use of support vector machines for disease risk prediction in genome-wide association studies: concerns and opportunities.
Human mutation 2012;33(12):1708-18.
2012: Margaux F Keller; Laura L Kilarski; Kari Majamaa; Maria Martinez; Florian Mittag; Huw R Morris; Valentina Moskvina; Michael A Nalls; Nayia Nicolaou; Mohamad Saad; Claudia Schulte; Manu Sharma; Javier Simón-Sánchez; Andrew B Singleton; Hreinn Stefánsson; Nigel Williams; Nicholas W Wood; Pauli Ylikotila; Francesco Bettella; Jose Bras; Alexis Brice; Finja Büchel; Alexandra Durr; Thomas Gasser; J Raphael Gibbs; Rita Guerreiro; John Hardy; Dena G Hernandez; Peter Heutink; Peter Holmans
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
Human molecular genetics 2012;21(22):4996-5009.
2012: John Hardy
CSF biomarking for diagnosis and treatment assessment in neurodegeneration.
Journal of neurochemistry 2012;123(3):339-41.
2012: R Paudel; Tamas Revesz; John Hardy; Janice L Holton; Henry Houlden
Review: genetics and neuropathology of primary pure dystonia.
Neuropathology and applied neurobiology 2012;38(6):520-34.
2012: Daniah Trabzuni; Jana Vandrovcova; Robert Walker; Michael E Weale; Selina Wray; Andrew B Singleton; Colin Smith; Sampath Arepalli; Mark R Cookson; Rohan de Silva; Allissa Dillman; J Raphael Gibbs; John Hardy; Dena G Hernandez; Connie Luk; Alan Pittman; Adaikalavan Ramasamy; Mina Ryten
MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies.
Human molecular genetics 2012;21(18):4094-103.
2012: Matthew E Gegg; John Hardy; Simon J R Heales; Derek Burke; J Mark Cooper; Nicholas W Wood; Anthony H V Schapira
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains.
Annals of neurology 2012;72(3):455-63.
2012: Georgia Xiromerisiou; Georgios M Hadjigeorgiou; John Hardy; Henry Houlden; Eleanna Kara; Prasad Korlipara; Andrew J Lees; Patricia Limousin; Reema Paudel; Nikolaos Scarmeas; Maria Stamelou; Kailash P Bhatia
THAP1 mutations and dystonia phenotypes: genotype phenotype correlations.
Movement disorders : official journal of the Movement Disorder Society 2012;27(10):1290-4.
2012: Eleanna Kara; Andrew Lees; Helen Ling; Alan Pittman; Rohan de Silva; John Hardy; Janice L Holton; Henry Houlden; Jonathan D Rohrer; Karen Shaw; Roberto Simone; Jason D Warren; Georgia Xiromerisiou; Tamas Revesz
The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features.
Neurobiology of aging 2012;33(9):2231.e7-2231.e14.
2012: Georgia Xiromerisiou; John Hardy; Henry Houlden; Anna Sailer; Laura Silveira-Moriyama; Andrew J Lees
Identical twins with Leucine rich repeat kinase type 2 mutations discordant for Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2012;27(10):1323.
2012: Michael C Kruer; Andrew Lees; Reema Paudel; Lynn Sanford; Wendy Wagoner; Kailash Bhatia; Tom Foltynie; Allison Gregory; John Hardy; Susan J Hayflick; Eleanna Kara; Henry Houlden
Analysis of ATP13A2 in large neurodegeneration with brain iron accumulation (NBIA) and dystonia-parkinsonism cohorts.
Neuroscience letters 2012;523(1):35-8.
2012: Raquel Duran; Timothy Cox; Patrick Deegan; Derralyn Hughes; Alisdair McNeill; Atul Mehta; Anthony H V Schapira; John Hardy
Novel pathogenic mutations in the glucocerebrosidase locus.
Molecular genetics and metabolism 2012;106(4):495-7.
2012: Raffaele Ferrari; Bernardino Ghetti; Jill Goldman; Jordan Grafman; John Hardy; Edward D Huey; Gregory A Jicha; Dimitrios Kapogiannis; Richard Mayeux; Kin Mok; Jorge H Moreno; Jill R Murrell; Pietro Pietrini; Michael C Tierney; Eric M Wassermann; Stephanie Cosentino; Parastoo Momeni
Screening for C9ORF72 repeat expansion in FTLD.
Neurobiology of aging 2012;33(8):1850.e1-11.
2012: Jose Bras; Rita Guerreiro; John Hardy
Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease.
Nature reviews. Neuroscience 2012;13(7):453-64.
2012: Dena G Hernandez; Matthew Moore; Mike A Nalls; Richard J O'Brien; Mina Ryten; Andrew B Singleton; Colin Smith; Daniah Trabzuni; Bryan Joseph Traynor; Juan C Troncoso; Robert Walker; Michael E Weale; Alan B Zonderman; Sampath Arepalli; Stefania Bandinelli; Sean Chong; Allissa Dillman; J Raphael Gibbs; John Hardy; Mark R Cookson
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.
Neurobiology of disease 2012;47(1):20-8.
2012: Valerija Dobricic; Nicole Gurunlian; John Hardy; Milena Jankovic; Vladimir Kostic; Ivana Novakovic; Elka Stefanova; Rita Guerreiro
Genetic testing in familial and young-onset Alzheimer's disease: mutation spectrum in a Serbian cohort.
Neurobiology of aging 2012;33(7):1481.e7-12.
2012: Arianna Tucci; Nicholas W Wood; Gavin Charlesworth; Vincent Plagnol; Una-Marie Sheerin; John Hardy
Study of the genetic variability in a Parkinson's Disease gene: EIF4G1.
Neuroscience letters 2012;518(1):19-22.
2012: John Hardy; Tamas Revesz
The spread of neurodegenerative disease.
The New England journal of medicine 2012;366(22):2126-8.
2012: Edward D Huey; Christopher Jensen; Rajesh N. Kalaria; Jorge H Moreno; Christopher M Morris; Felix Potocnik; Michael Tierney; Eric M Wassermann; Raffaele Ferrari; Jordan Grafman; John Hardy; Parastoo Momeni
FUS and TDP43 genetic variability in FTD and CBS.
Neurobiology of aging 2012;33(5):1016.e9-17.
2012: John Hardy
Genetic analysis of disease in the era of whole genome analysis and public databases.
Neurobiology of aging 2012;33(4):635.
2012: Gavin Charlesworth; Patrick F Chinnery; Sonia Gandhi; Stephen M Gentleman; Rita Guerreiro; John Hardy; Janice L Holton; Andrew J Lees; Huw Morris; Karen Morrison; Tamas Revesz; Una-Marie Sheerin; Nigel Williams; Roger A Barker; Jose M Bras; David J Burn; Nicholas W Wood
Tau acts as an independent genetic risk factor in pathologically proven PD.
Neurobiology of aging 2012;33(4):838.e7-11.
2012: Coro Paisan-Ruiz; Tamas Revesz; Susanne A Schneider; Kailash P Bhatia; Jeremy Chataway; John Hardy; Janice L Holton; Robert Johnson; Desmond Kidd; Andrew J Lees; Abi Li; Henry Houlden
Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations.
Neurobiology of aging 2012;33(4):814-23.
2012: Jason D Warren; Jonathan D Rohrer; John Hardy
Disintegrating brain networks: from syndromes to molecular nexopathies.
Neuron 2012;73(6):1060-2.
2012: Colin J Mahoney; simon mead; Kin Mok; Tamas Revesz; Jonathan D Rohrer; Martin N Rossor; Jonathan M Schott; Tim Shakespeare; Jon Beck; John Collinge; Nick C Fox; John Hardy; Tammaryn Lashley; Elizabeth K Warrington; Tom Yeatman; Jason D Warren
Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features.
Brain : a journal of neurology 2012;135(Pt 3):736-50.
2012: Rita Guerreiro; Deborah R Gustafson; John Hardy
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.
Neurobiology of aging 2012;33(3):437-56.
2012: Elisa Majounie; Rodney T Perry; Olga Pletnikova; Alan E Renton; Andrew B Singleton; Yevgeniya Abramzon; Susan S Bassett; John Hardy; Juan C Troncoso; Bryan Joseph Traynor
Repeat expansion in C9ORF72 in Alzheimer's disease.
The New England journal of medicine 2012;366(3):283-4.
2012: Robert P Friedland; Lindsay A Farrer; Kin Mok; Jovan D Rebolledo-Mendez; Jignesh J Shah; Badri Vardarajan; John Hardy
Behavioral variant frontotemporal lobar degeneration with amyotrophic lateral sclerosis with a chromosome 9p21 hexanucleotide repeat.
Frontiers in neurology 2012;3():136.
2012: Helen Crehan; John Hardy; Jennifer Pocock
Microglia, Alzheimer's disease, and complement.
International journal of Alzheimer's disease 2012;2012():983640.
2012: Iain Rogers; John Hardy; Fiona Kerr; Simon Lovestone; Pedro Martinez; Linda Partridge
Ageing increases vulnerability to aβ42 toxicity in Drosophila.
PloS one 2012;7(7):e40569.
2012: Javier Simón-Sánchez; Andrew B Singleton; Nigel Williams; Nicholas W Wood; Michael A Nalls; Claudia Schulte; Alexis Brice; Thomas Gasser; John Hardy; Peter Heutink; Peter Holmans; Laura L Kilarski; Maria Martinez; Huw R Morris
Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease.
PloS one 2012;7(3):e28787.
2012: Kin Mok; Gabriele Mora; Huw R Morris; Karen E Morrison; Liisa Myllykangas; Michael A Nalls; Richard W Orrell; Terhi Peuralinna; Stuart Pickering-Brown; Rosa Rademakers; Gabriella Restagno; Pamela Sara Rollinson; Jennifer C Schymick; Aleksey Shatunov; Pamela J Shaw; Javier Simón-Sánchez; Pentti J Tienari; Bryan Joseph Traynor; John C van Swieten; Adrian Waite; Nigel Williams; Ammar Al-Chalabi; Bradley F Boeve; Adam L Boxer; Adriano Chio; Mariely DeJesus-Hernandez; Peter Heutink; Hannu Laaksovirta; Ian R Mackenzie; John Hardy
Chromosome 9 ALS and FTD locus is probably derived from a single founder.
Neurobiology of aging 2012;33(1):209.e3-8.
2011: John Hardy; Rita Guerreiro; Simon Lovestone
Clusterin as an Alzheimer biomarker.
Archives of neurology 2011;68(11):1459-60.
2011: Raffaele Ferrari; John Hardy; Parastoo Momeni
Frontotemporal dementia: from Mendelian genetics towards genome wide association studies.
Journal of molecular neuroscience : MN 2011;45(3):500-15.
2011: James F Meschia; Michael Nalls; Kerra Pearce; Stephen S Rich; Andrew Singleton; Bradford Worrall; Thomas G Brott; Robert D Brown; Luigi Ferrucci; John Hardy; Dena Hernandez; Margaret Keller; Brett Kissela; Mar Matarin
Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci.
Stroke; a journal of cerebral circulation 2011;42(10):2726-32.
2011: Michael J Devine; Katrina Gwinn-Hardy; Andrew Singleton; John Hardy
Parkinson's disease and α-synuclein expression.
Movement disorders : official journal of the Movement Disorder Society 2011;26(12):2160-8.
2011: Daniah Trabzuni; Robert Walker; Michael E Weale; Sabaena Imran; Adaikalavan Ramasamy; Mina Ryten; Colin Smith; John Hardy
Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies.
Journal of neurochemistry 2011;119(2):275-82.
2011: Jonathan D Rohrer; Martin N Rossor; Jonathan M Schott; Claire Troakes; Jane E Warren; Elizabeth Warrington; Safa Al-Sarraj; Jonathan Beck; Barbara Borroni; Matthew J Clarkson; Rohan de Silva; Nick C Fox; John Hardy; Janice L Holton; Adrian M Isaacs; Andrew King; Tammaryn Lashley; simon mead; Sébastien Ourselin; Tamas Revesz; Jason D Warren
Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration.
Brain : a journal of neurology 2011;134(Pt 9):2565-81.
2011: Katrina Gwinn-Hardy; John Hardy; Henry Houlden; Lee-Way Jin; Janel Johnson; Grisel Lopez; MD Muenter; Charles H Adler; Thomas D Bird; Richard Caselli; Michael J Devine; Amanda Singleton; Cheryl Waters; Andrew Singleton
Clinical features, with video documentation, of the original familial lewy body parkinsonism caused by α-synuclein triplication (Iowa kindred).
Movement disorders : official journal of the Movement Disorder Society 2011;26(11):2134-6.
2011: Sarah Teixeira Camargos; Juliana Gurgel-Giannetti; John Hardy; Andrew J Lees; Andrew Singleton; Francisco Cardoso
Low prevalence of PANK2 mutations in Brazilian patients with early onset generalised dystonia and basal ganglia abnormalities on MRI.
Journal of neurology, neurosurgery, and psychiatry 2011;82(9):1059-60.
2011: Rita J Guerreiro; John Hardy
Alzheimer's disease genetics: lessons to improve disease modelling.
Biochemical Society transactions 2011;39(4):910-6.
2011: Günter U Höglinger; Howard I Hurtig; Lambertus Klei; Andrew J Lees; Irene Litvan; Walter Maetzler; Nadine M Melhem; Ulrich Müller; Pau Pastor; Rosa Rademakers; Tamas Revesz; David E Riley; Andrew B Singleton; Patrick M A Sleiman; Eduardo Tolosa; Ryan J Uitti; Marcel P van der Brug; John C van Swieten; Jana Vandrovcova; Li-San Wang; Zbigniew K Wszolek; Chang-En Yu; Barbara Borroni; Laura B Cantwell; Mark R Cookson; Rohan de Silva; Bernie Devlin; dennis dickson; Allissa Dillman; Matthew J Farrer; J Raphael Gibbs; Lawrence I Golbe; Stefano Goldwurm; Rachel G Gross; Hakon Hakonarson; Mi Ryung Han; John Hardy; Dena G Hernandez; Peter Heutink; Gerard D Schellenberg
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
Nature genetics 2011;43(7):699-705.
2011: Robert Balazs; Jeffrey Vernon; John Hardy
Epigenetic mechanisms in Alzheimer's disease: progress but much to do.
Neurobiology of aging 2011;32(7):1181-7.
2011: Thomas Gasser; John Hardy; Yoshikuni Mizuno
Milestones in PD genetics.
Movement disorders : official journal of the Movement Disorder Society 2011;26(6):1042-8.
2011: Cecilia Marelli; Joyce van de Leemput; Janel O Johnson; Francois Tison; Christel Thauvin-Robinet; Fabienne Picard; Christine Tranchant; Dena G Hernandez; Bernard Huttin; Jacques Boulliat; Iban Sangla; Christian Marescaux; Serge Brique; Hélène Dollfus; Sampath Arepalli; Isabelle Benatru; Elisabeth Ollagnon; Sylvie Forlani; John Hardy; Giovanni Stevanin; Alexandra Dürr; Andrew Singleton; Alexis Brice
SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia.
Archives of neurology 2011;68(5):637-43.
2011: John Hardy; Nancy C Low
Genes and environment in psychiatry: winner's curse or cure?
Archives of general psychiatry 2011;68(5):455-6.
2011: John Hardy; Rita Guerreiro
A new way APP mismetabolism can lead to Alzheimer's disease.
EMBO molecular medicine 2011;3(5):247-8.
2011: Adam C Naj; Gyungah Jun; Gary Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew Huentelman; Amanda Myers; M. Michael Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Steven E Arnold; Robert C Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; dennis dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas Galasko; Mary Ganguli; Marla Gearing; Daniel Geschwind; Bernardino Ghetti; John Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C. Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret Pericak-Vance; Lindsay A Farrer; Peter St George-Hyslop; Gerard D Schellenberg
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Nature genetics 2011;43(5):436-41.
2011: Paul Hollingworth; Peter A Holmans; Clive Holmes; Nigel M Hooper; Michael Hüll; M Arfan Ikram; Dobril Ivanov; Frank Jessen; Karl-Heinz Jöckel; Lesley Jones; Nicola Jones; Palmi V Jonsson; Thorlakur Jonsson; John S K Kauwe; Patrick G Kehoe; Norman Klopp; Heike Kölsch; Johannes Kornhuber; Michael Krawczak; Jean-Charles Lambert; Mark Lathrop; Lenore J Launer; Brian Lawlor; Federico Licastro; Gill Livingston; Oscar L Lopez; Seth Love; Simon Lovestone; Michelle K Lupton; Aoibhinn Lynch; Wolfgang Maier; Michelangelo Mancuso; David Mann; Ignacio Mateo; Manuel Mayhaus; Kevin Mayo; Bernadette McGuinness; Andrew McQuillin; Simon Mead; Susanne Moebus; Kevin Morgan; John C Morris; Valentina Moskvina; Thomas W Mühleisen; Benedetta Nacmias; S Nicolhaus; Markus M Nöthen; Petra Nowotny; Michael O'Donovan; Michael J Owen; Jaspreet Singh Pahwa; V Shane Pankratz; Francesco Panza; Florence Pasquier; Peter A Passmore; Ronald C. Petersen; Paola Piccardi; Alberto Pilotto; Elisa Porcellini; John Powell; Petroula Proitsi; Alex Richards; Caterina Riehle; Matthias Riemenschneider; Martin N Rossor; David C Rubinsztein; Dan Rujescu; Eckart Rüther; Sigrid B Sando; Elio Scarpini; Stefan Schreiber; Britta Schürmann; Davide Seripa; Sudha Seshadri; Christopher E Shaw; Gabriele Siciliano; Rebecca Sims; Andrew B Singleton; Kristel Sleegers; A David Smith; Jon Snaedal; Hilkka Soininen; Vincenzo Solfrizzi; Sandro Sorbi; Hreinn Stefansson; Kari Stefansson; Stacy Steinberg; Alexandra Stretton; Charlene Thomas; Stephen Todd; Magda Tsolaki; Christophe Tzourio; Christine Van Broeckhoven; Hendrik van den Bussche; Cornelia M van Duijn; Emma R L C Vardy; Stefan Wagenpfeil; Donald Warden; H-Erich Wichmann; Caroline Widdowson; Gordon Wilcock; Jan O Aasly; Richard Abraham; Ammar Al-Chalabi; Annick Alpérovitch; Victoria Alvarez; Philippe Amouyel; Giorgio Annoni; Beatrice Arosio; Maria Barcikowska; Nicholas J Bass; Helen Beaumont; Claudine Berr; Karolien Bettens; Sigurbjörn Björnsson; Paolo Bosco; Paola Bossù; Carol Brayne; Monique Breteler; Alexis Brice; Kristelle S Brown; Maria J Bullido; Dominique Campion; Minerva M Carrasquillo; Jade Chapman; Vincent Chouraki; John Collinge; Onofre Combarros; Eliecer Coto; David Craig; Carlos Cruchaga; Jean-François Dartigues; Peter P De Deyn; Marc Delepine; Panagiotis Deloukas; Anita L DeStefano; Martin Dichgans; dennis dickson; Kimberley Dowzell; Sebastiaan Engelborghs; Jacques Epelbaum; Thomas M Feulner; Annette L Fitzpatrick; Nick C Fox; Ana Frank-Garcia; Patricia Friedrich; Lutz Frölich; Daniela Galimberti; John Gallacher; Benjamin Genier-Boley; Amy Gerrish; Ina Giegling; Michael Gill; Alison Goate; Neill R Graff-Radford; Rita Guerreiro; Hugh Gurling; Rhian Gwilliam; Harald Hampel; Marian L Hamshere; Didier Hannequin; Olivier Hanon; John Hardy; Denise Harold; Reiner Heun; Isabella Heuser; Mikko Hiltunen; Jens Wiltfang; Zbigniew K Wszolek; Steven G Younkin; Diana Zelenika; Julie Williams
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Nature genetics 2011;43(5):429-35.
2011: Sara Rollinson; Simon Mead; Julie Snowden; Anna Richardson; Jonathan Rohrer; Nicola Halliwell; Suzanne Usher; David Neary; David Mann; John Hardy; Stuart Pickering-Brown
Frontotemporal lobar degeneration genome wide association study replication confirms a risk locus shared with amyotrophic lateral sclerosis.
Neurobiology of aging 2011;32(4):758.e1-7.
2011: Lori B Chibnik; Joshua M Shulman; Sue E Leurgans; Julie A Schneider; Robert S Wilson; Dong Tran; Cristin Aubin; Aron S Buchman; Christopher B Heward; Amanda Myers; John Hardy; Matthew Huentelman; Jason J Corneveaux; Eric Reiman; Denis A Evans; David A Bennett; Philip De Jager
CR1 is associated with amyloid plaque burden and age-related cognitive decline.
Annals of neurology 2011;69(3):560-9.
2011: Michael A Nalls; Vincent Plagnol; Dena G Hernandez; Manu Sharma; Una-Marie Sheerin; Mohamad Saad; J Simón-Sánchez; Claudia Schulte; Suzanne Lesage; Sigurlaug Sveinbjörnsdóttir; Kári Stefánsson; Maria Martinez; John Hardy; Peter Heutink; Alexis Brice; Thomas Gasser; Andrew B Singleton; Nicholas W Wood
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
Lancet 2011;377(9766):641-9.
2011: James F Meschia; Michael A Nalls; Kerra Pearce; Stephen S Rich; Pankaj Sharma; Andrew Singleton; Thomas G Brott; Robert D Brown; Luigi Ferrucci; John Hardy; Dena G Hernandez; Mar Matarin; Bradford Worrall
Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis.
PloS one 2011;6(9):e23161.
2011: Michael J Devine; Nicola J Drummond; Katrina Gwinn-Hardy; John Hardy; Henry Houlden; Patrick A Lewis; Masumi Nagano; Mina Ryten; Anthony H Schapira; Jan-Willem Taanman; Alison J Thomson; Petr Vodicka; Tom Burdon; Fatima Cavaleri; Tilo Kunath
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
Nature communications 2011;2():440.
2011: Michael J Devine; Allissa Dillman; John Hardy; Daniel Healey; Susannah Horan; Alice Kaganovich; Rina Bandopadhyay; Diane Chan; Mark Cookson; Adamantios Mamais; Claudia Manzoni; Jose-Felix Marti-Masso; Philip McGoldrick; Mina Ryten; Anthony H Schapira; Jan-Willem Taanman; Daniah Trabzuni; Marcel van der Brug; Benjamin Wolozin; Julia Zerle; Daniel Healy; Patrick A Lewis
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
PloS one 2011;6(7):e22489.
2011: Terhi Peuralinna; Tuomo Polvikoski; Andrew Singleton; Raimo Sulkava; Maarit Tanskanen; Pentti J Tienari; Bryan Joseph Traynor; Sampath Arepalli; John Hardy; Dena Hernandez; Hannu Kalimo; Shiao-Lin Lai; Mira Mäkelä; Anders Paetau; Liisa Myllykangas
APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis.
Journal of Alzheimer's disease : JAD 2011;26(2):377-85.
2011: John Hardy; Alan J Thompson
Dissecting the familial risk of multiple sclerosis.
Annals of neurology 2011;69(1):11-2.
2010: Parastoo Momeni; Mirdhu M Wickremaratchi; Jason Bell; Richard Arnold; Roger Beer; John Hardy; Tamas Revesz; James W Neal; Huw R Morris
Familial early onset frontotemporal dementia caused by a novel S356T MAPT mutation, initially diagnosed as schizophrenia.
Clinical neurology and neurosurgery 2010;112(10):917-20.
2010: Jana Vandrovcova; F Anaya; V Kay; Andrew J Lees; John Hardy; Rohan de Silva
Disentangling the role of the tau gene locus in sporadic tauopathies.
Current Alzheimer research 2010;7(8):726-34.
2010: Arianna Tucci; Mike A Nalls; Henry Houlden; Tamas Revesz; Andrew Singleton; Nicholas W Wood; John Hardy; Coro Paisan-Ruiz
Genetic variability at the PARK16 locus.
European journal of human genetics : EJHG 2010;18(12):1356-9.
2010: Tohru Matsuki; Russell T Matthews; Jonathan A Cooper; Marcel P van der Brug; Mark Cookson; John Hardy; Eric C Olson; Brian W Howell
Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.
Cell 2010;143(5):826-36.
2010: Michael C Kruer; Coro Paisan-Ruiz; Nathalie Boddaert; Moon Y Yoon; Hiroko Hama; Allison Gregory; Alessandro Malandrini; Randall L Woltjer; Arnold Munnich; Stephanie Gobin; Brenda J Polster; Silvia Palmeri; Simon Edvardson; John Hardy; Henry Houlden; Susan J Hayflick
Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA).
Annals of neurology 2010;68(5):611-8.
2010: John Hardy
Genetic analysis of pathways to Parkinson disease.
Neuron 2010;68(2):201-6.
2010: John Hardy
Sample tracking and use in published genome-wide association studies.
Archives of neurology 2010;67(10):1267-8.
2010: Andrew Singleton; John Hardy; Bryan Joseph Traynor; Henry Houlden
Towards a complete resolution of the genetic architecture of disease.
Trends in genetics : TIG 2010;26(10):438-42.
2010: Aleksey Shatunov; Kin Mok; Stephen Newhouse; Michael E Weale; Bradley Smith; Caroline Vance; Lauren Johnson; Jan H Veldink; Michael A van Es; Leonard H van den Berg; Wim Robberecht; Philip Van Damme; Orla Hardiman; Anne E Farmer; Cathryn M Lewis; Amy W Butler; Olubunmi Abel; Peter M Andersen; Isabella Fogh; Vincenzo Silani; Adriano Chiò; Bryan Joseph Traynor; Judith Melki; Vincent Meininger; John E Landers; Peter McGuffin; Jonathan D Glass; Hardev Pall; P Nigel Leigh; John Hardy; Robert H Brown; John F Powell; Richard W Orrell; Karen E Morrison; Pamela J Shaw; Christopher E Shaw; Ammar Al-Chalabi
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
Lancet neurology 2010;9(10):986-94.
2010: Coro Paisan-Ruiz; Rocio Guevara; Monica Federoff; Hasmet Hanagasi; Fardaz Sina; Elahe Elahi; Susanne A Schneider; Petra Schwingenschuh; Nin Bajaj; Murat Emre; Andrew Singleton; John Hardy; Kailash P Bhatia; Sebastian Brandner; Andrew J Lees; Henry Houlden
Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations.
Movement disorders : official journal of the Movement Disorder Society 2010;25(12):1791-800.
2010: Oyinkan Sofola; Fiona Kerr; Iain Rogers; Richard Killick; Hrvoje Augustin; Carina Gandy; Marcus J Allen; John Hardy; Simon Lovestone; Linda Partridge
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.
PLoS genetics 2010;6(9):.
2010: Jason J Corneveaux; Amanda Myers; April N Allen; Jeremy J Pruzin; Manuel Ramirez; Anzhelika Engel; Michael A Nalls; Kewei Chen; Wendy Lee; Kendria Chewning; Stephen E Villa; Hunsar B Meechoovet; Jill D Gerber; Danielle Frost; Hollie L Benson; Sean O'Reilly; Lori B Chibnik; Joshua M Shulman; Andrew Singleton; David Craig; Kendall R Van Keuren-Jensen; Travis Dunckley; David A Bennett; Philip L De Jager; Christopher Heward; John Hardy; Eric Reiman; Matthew Huentelman
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
Human molecular genetics 2010;19(16):3295-301.
2010: Annu Aggarwal; Susanne A Schneider; Henry Houlden; Monty Silverdale; Reema Paudel; Coro Paisan-Ruiz; Shrinivas Desai; Mihir Munshi; Darshana Sanghvi; John Hardy; Kailash P Bhatia; Mohit Bhatt
Indian-subcontinent NBIA: unusual phenotypes, novel PANK2 mutations, and undetermined genetic forms.
Movement disorders : official journal of the Movement Disorder Society 2010;25(10):1424-31.
2010: Thomas Zetzsche; Dan Rujescu; John Hardy; Harald Hampel
Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease.
Expert review of molecular diagnostics 2010;10(5):667-90.
2010: Harald Hampel; Richard Frank; Karl Broich; Stefan J Teipel; Russell G Katz; John Hardy; Karl Herholz; Arun L W Bokde; Frank Jessen; Yvonne C Hoessler; Wendy R Sanhai; Henrik Zetterberg; Janet Woodcock; Kaj Blennow
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives.
Nature reviews. Drug discovery 2010;9(7):560-74.
2010: Susanne A Schneider; Coro Paisan-Ruiz; Niall Quinn; Andrew J Lees; Henry Houlden; John Hardy; Kailash P Bhatia
ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation.
Movement disorders : official journal of the Movement Disorder Society 2010;25(8):979-84.
2010: John Hardy; Julie Williams
Identification of Alzheimer risk factors through whole-genome analysis.
Archives of neurology 2010;67(6):663-4.
2010: Parastoo Momeni; Karen DeTucci; Richard E Straub; Daniel R Weinberger; Peter Davies; Jordan Grafman; John Hardy; Edward D Huey
Progranulin (GRN) in two siblings of a Latino family and in other patients with schizophrenia.
Neurocase 2010;16(3):273-9.
2010: Stephanie Schorge; Joyce van de Leemput; Andrew Singleton; Henry Houlden; John Hardy
Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling.
Trends in neurosciences 2010;33(5):211-9.
2010: Rita Joao Guerreiro; Miquel Baquero; Rafael Blesa; Mercè Boada; Jose Miguel Brás; Maria J Bullido; Ana Calado; Richard Crook; Carla Ferreira; Ana Frank; Teresa Gómez-Isla; Isabel Hernández; Alberto Lleó; Alvaro Machado; Pablo Martínez-Lage; José Masdeu; Laura Molina-Porcel; José L Molinuevo; Pau Pastor; Jordi Pérez-Tur; Rute Relvas; Catarina Resende Oliveira; Maria Helena Ribeiro; Ekaterina Rogaeva; Alfredo Sa; Lluís Samaranch; Raquel Sánchez-Valle; Isabel Santana; Lluís Tàrraga; Fernando Valdivieso; Andrew Singleton; John Hardy; Jordi Clarimón
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP.
Neurobiology of aging 2010;31(5):725-31.
2010: Joyce van de Leemput; Fabienne Wavrant-De Vrièze; Ian Rafferty; Jose M Bras; Paola Giunti; Elizabeth M C Fisher; John Hardy; Andrew Singleton; Henry Houlden
Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series.
Movement disorders : official journal of the Movement Disorder Society 2010;25(6):771-3.
2010: John Hardy
Neurological diagnoses identify molecular processes.
Archives of neurology 2010;67(4):400-1.
2010: Henry Houlden; Susanne A Schneider; R Paudel; A Melchers; P Schwingenschuh; M Edwards; John Hardy; Kailash P Bhatia
THAP1 mutations (DYT6) are an additional cause of early-onset dystonia.
Neurology 2010;74(10):846-50.
2010: Vivianna M Van Deerlin; Patrick M A Sleiman; Maria Martinez-Lage; Alice Chen-Plotkin; Li-San Wang; Neill R Graff-Radford; dennis dickson; Rosa Rademakers; Bradley F Boeve; Murray Grossman; Steven E Arnold; D M A Mann; Stuart M Pickering-Brown; Harro Seelaar; Peter Heutink; John C van Swieten; Jill R Murrell; Bernardino Ghetti; Salvatore Spina; Jordan Grafman; John R Hodges; Maria Grazia Spillantini; Sid Gilman; Andrew P Lieberman; Jeffrey A Kaye; Randall L Woltjer; Eileen H Bigio; Marsel Mesulam; Safa Al-Sarraj; Claire Troakes; Roger N Rosenberg; Charles L White; Isidro Ferrer; Albert Lladó; Manuela Neumann; Hans A Kretzschmar; Christine Marie Hulette; Kathleen A Welsh-Bohmer; Bruce L Miller; Ainhoa Alzualde; Adolfo Lopez de Munain; Ann C McKee; Marla Gearing; Allan Levey; James J Lah; John Hardy; Jonathan D Rohrer; Tammaryn Lashley; Ian R A Mackenzie; Howard H Feldman; Ronald L Hamilton; Steven T DeKosky; Julie van der Zee; Samir Kumar-Singh; Christine Van Broeckhoven; Richard Mayeux; Jean Paul G Vonsattel; Juan C Troncoso; Jillian J Kril; John B J Kwok; Glenda M Halliday; Thomas D Bird; Paul Geoffrey Ince; Pamela J Shaw; Nigel J Cairns; John C Morris; Catriona Ann McLean; Charles DeCarli; William G Ellis; Stefanie H Freeman; Matthew P Frosch; John H Growdon; Daniel P Perl; Mary Sano; David A Bennett; Julie A Schneider; Thomas Beach; Eric Reiman; Bryan Woodruff; Jeffrey L Cummings; Harry V Vinters; Carol A Miller; Helena C Chui; Irina Alafuzoff; Päivi Hartikainen; Danielle Seilhean; Douglas Galasko; Eliezer Masliah; Carl W Cotman; M Teresa Tuñón; M Cristina Caballero Martínez; David G Munoz; Steven L Carroll; Daniel Marson; Peter F Riederer; Nenad Bogdanovic; Gerard D Schellenberg; Hakon Hakonarson; John Q Trojanowski; Virginia M-Y Lee
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Nature genetics 2010;42(3):234-9.
2010: M Matarin; Andrew Singleton; John Hardy; J Meschia
The genetics of ischaemic stroke.
Journal of internal medicine 2010;267(2):139-55.
2010: Rita J Guerreiro; Nicole Washecka; John Hardy; Andrew Singleton
A thorough assessment of benign genetic variability in GRN and MAPT.
Human mutation 2010;31(2):E1126-40.
2010: Bryan Maloney; Yuan-Wen Ge; Ronald C. Petersen; John Hardy; Jack T Rogers; Jordi Pérez-Tur; Debomoy K Lahiri
Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(1):185-201.
2010: Hélène Plun-Favreau; Patrick A Lewis; John Hardy; L Miguel Martins; Nicholas W Wood
Cancer and neurodegeneration: between the devil and the deep blue sea.
PLoS genetics 2010;6(12):e1001257.
2010: Lesley Jones; Peter A Holmans; Marian L Hamshere; Denise Harold; Valentina Moskvina; Dobril Ivanov; Andrew Pocklington; Richard Abraham; Paul Hollingworth; Rebecca Sims; Amy Gerrish; Jaspreet Singh Pahwa; Nicola Jones; Alexandra Stretton; Angharad R Morgan; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K Lupton; Carol Brayne; David C Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kevin Morgan; Kristelle S Brown; Peter A Passmore; David Craig; Bernadette McGuinness; Stephen Todd; Clive Holmes; David Mann; A David Smith; Seth Love; Patrick G Kehoe; Simon Mead; Nick C Fox; Martin N Rossor; John Collinge; Wolfgang Maier; Frank Jessen; Britta Schürmann; Reinhard Heun; Heike Kölsch; Hendrik van den Bussche; Isabella Heuser; Oliver Peters; Johannes Kornhuber; Jens Wiltfang; Martin Dichgans; Lutz Frölich; Harald Hampel; Michael Hüll; Dan Rujescu; Alison Goate; John S K Kauwe; Carlos Cruchaga; Petra Nowotny; John C Morris; Kevin Mayo; Gill Livingston; Nicholas J Bass; Hugh Gurling; Andrew McQuillin; Rhian Gwilliam; Panos Deloukas; Ammar Al-Chalabi; Christopher E Shaw; Andrew Singleton; Rita Guerreiro; Thomas W Mühleisen; Markus M Nöthen; Susanne Moebus; Karl-Heinz Jöckel; Norman Klopp; H-Erich Wichmann; Eckhard Rüther; Minerva M Carrasquillo; V Shane Pankratz; Steven G Younkin; John Hardy; Michael C O'Donovan; Michael J Owen; Julie Williams
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.
PloS one 2010;5(11):e13950.
2010: Rita Guerreiro; John Beck; J Raphael Gibbs; Isabel Santana; Martin N Rossor; Jonathan M Schott; Michael A Nalls; Helena Ribeiro; Beatriz Santiago; Nick C Fox; Catarina Oliveira; John Collinge; Simon Mead; Andrew Singleton; John Hardy
Genetic variability in CLU and its association with Alzheimer's disease.
PloS one 2010;5(3):e9510.
2010: Chaolong Wang; Zachary A Szpiech; James H Degnan; Mattias Jakobsson; Trevor J Pemberton; John Hardy; Andrew Singleton; Noah A Rosenberg
Comparing spatial maps of human population-genetic variation using Procrustes analysis.
Statistical applications in genetics and molecular biology 2010;9():Article 13.
2010: John Hardy; Katrina Gwinn-Hardy
Protected to death.
Journal of Alzheimer's disease : JAD 2010;20(2):409-13.
2009: Javier Simón-Sánchez; Claudia Schulte; Jose M Bras; Manu Sharma; J Raphael Gibbs; Daniela Berg; Coro Paisan-Ruiz; Peter Lichtner; Sonja W Scholz; Dena G Hernandez; Rejko Krüger; Monica Federoff; Christine Klein; Alison Goate; Joel Perlmutter; Michael Bonin; Michael A Nalls; Thomas Illig; Christian Gieger; Henry Houlden; Michael Steffens; Michael S Okun; Brad A Racette; Mark Cookson; Kelly D Foote; Hubert H Fernandez; Bryan Joseph Traynor; Stefan Schreiber; Sampath Arepalli; Ryan Zonozi; Katrina Gwinn-Hardy; Marcel van der Brug; Grisel Lopez; STEPHEN CHANOCK; Arthur Schatzkin; Yikyung Park; Albert Russell Hollenbeck; Jianjun Gao; Xuemei Huang; Nick W Wood; Delia Lorenz; Günther Deuschl; Honglei Chen; Olaf Riess; John Hardy; Andrew Singleton; Thomas Gasser
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Nature genetics 2009;41(12):1308-12.
2009: dennis dickson; Heiko Braak; John E Duda; Charles Duyckaerts; Thomas Gasser; Glenda M Halliday; John Hardy; James B Leverenz; Kelly Del Tredici; Zbigniew K Wszolek; Irene Litvan
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.
Lancet neurology 2009;8(12):1150-7.
2009: John Hardy; Danyah Trabzuni; Mina Ryten
Whole genome expression as a quantitative trait.
Biochemical Society transactions 2009;37(Pt 6):1276-7.
2009: Jordi Clarimón; R Djaldetti; Alberto Lleó; R J Guerreiro; J L Molinuevo; Coro Paisan-Ruiz; Teresa Gómez-Isla; Rafael Blesa; Andrew Singleton; John Hardy
Whole genome analysis in a consanguineous family with early onset Alzheimer's disease.
Neurobiology of aging 2009;30(12):1986-91.
2009: Jonathan D Rohrer; R Guerreiro; Jana Vandrovcova; J Uphill; D Reiman; Jon Beck; A M Isaacs; A Authier; R Ferrari; Nick C Fox; I R A Mackenzie; Jason D Warren; Rohan de Silva; Janice Holton; Tamas Revesz; John Hardy; simon mead; Martin N Rossor
The heritability and genetics of frontotemporal lobar degeneration.
Neurology 2009;73(18):1451-6.
2009: Mar Matarin; W Mark Brown; Hernandez Dena; Angela Britton; Fabienne Wavrant De Vrieze; Thomas G Brott; Robert D Brown; Bradford Worrall; L Douglas Case; STEPHEN CHANOCK; E Jeffrey Metter; Luigi Ferrucci; Dale Gamble; John Hardy; Stephen S Rich; Andrew Singleton; James F Meschia
Candidate gene polymorphisms for ischemic stroke.
Stroke; a journal of cerebral circulation 2009;40(11):3436-42.
2009: Ravindran Kumaran; Jana Vandrovcova; Connie Luk; Simone Sharma; Adrian Renton; Nicholas W Wood; John Hardy; Andrew J Lees; Rina Bandopadhyay
Differential DJ-1 gene expression in Parkinson's disease.
Neurobiology of disease 2009;36(2):393-400.
2009: Denise Harold; Richard Abraham; Paul Hollingworth; Rebecca Sims; Amy Gerrish; Marian L Hamshere; Jaspreet Singh Pahwa; Valentina Moskvina; Kimberley Dowzell; Amy Williams; Nicola Jones; Charlene Thomas; Alexandra Stretton; Angharad R Morgan; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K Lupton; Carol Brayne; David C Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kevin Morgan; Kristelle S Brown; Peter A Passmore; David Craig; Bernadette McGuinness; Stephen Todd; Clive Holmes; D M A Mann; A David Smith; Seth Love; Patrick G Kehoe; John Hardy; Simon Mead; Nick C Fox; Martin N Rossor; John Collinge; Wolfgang Maier; Frank Jessen; Britta Schürmann; Hendrik van den Bussche; Isabella Heuser; Johannes Kornhuber; Jens Wiltfang; Martin Dichgans; Lutz Froelich; Harald Hampel; Michael Hüll; Dan Rujescu; Alison Goate; John S K Kauwe; Carlos Cruchaga; Petra Nowotny; John C Morris; Kevin Mayo; Kristel Sleegers; Karolien Bettens; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Gillian Livingston; Nicholas J Bass; Hugh Gurling; Andrew McQuillin; Rhian Gwilliam; Panagiotis Deloukas; Ammar Al-Chalabi; Christopher Shaw; Magda Tsolaki; Andrew Singleton; Rita Guerreiro; Thomas W Mühleisen; Markus M Nöthen; Susanne Moebus; Karl-Heinz Jöckel; Norman Klopp; H-Erich Wichmann; Minerva M Carrasquillo; V Shane Pankratz; Steven G Younkin; Peter A Holmans; Michael O'Donovan; Michael J Owen; Julie Williams
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Nature genetics 2009;41(10):1088-93.
2009: Rita J Guerreiro; Tina Vaskov; Cynthia Crews; Andrew Singleton; John Hardy
A case of dementia with PRNP D178Ncis-129M and no insomnia.
Alzheimer disease and associated disorders 2009;23(4):415-7.
2009: Susanne A Schneider; Coro Paisan-Ruiz; Ines Garcia-Gorostiaga; Niall Quinn; Yvonne G Weber; Holger Lerche; John Hardy; Kailash P Bhatia
GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias.
Movement disorders : official journal of the Movement Disorder Society 2009;24(11):1684-8.
2009: John Hardy
The amyloid hypothesis for Alzheimer's disease: a critical reappraisal.
Journal of neurochemistry 2009;110(4):1129-34.
2009: Juliane Neumann; Jose Bras; Emma Deas; Sean S O'Sullivan; Laura Parkkinen; Robin H Lachmann; Abi Li; Janice Holton; Rita Guerreiro; Reema Paudel; Badmavady Segarane; Andrew Singleton; Andrew J Lees; John Hardy; Henry Houlden; Tamas Revesz; Nicholas W Wood
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease.
Brain : a journal of neurology 2009;132(Pt 7):1783-94.
2009: M A Nalls; R J Guerreiro; Javier Simon-Sanchez; J T Bras; Bryan Joseph Traynor; J Raphael Gibbs; L Launer; John Hardy; Andrew Singleton
Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.
Neurogenetics 2009;10(3):183-90.
2009: Andrew J Lees; John Hardy; Tamas Revesz
Parkinson's disease.
Lancet 2009;373(9680):2055-66.
2009: John Hardy; Patrick Lewis; Tamas Revesz; Andrew J Lees; Coro Paisan-Ruiz
The genetics of Parkinson's syndromes: a critical review.
Current opinion in genetics & development 2009;19(3):254-65.
2009: S A Schneider; John Hardy; K P Bhatia
Iron accumulation in syndromes of neurodegeneration with brain iron accumulation 1 and 2: causative or consequential?
Journal of neurology, neurosurgery, and psychiatry 2009;80(6):589-90.
2009: Mina Ryten; Danyah Trabzuni; John Hardy
Genotypic analysis of gene expression in the dissection of the aetiology of complex neurological and psychiatric diseases.
Briefings in functional genomics & proteomics 2009;8(3):194-8.
2009: Sonja W Scholz; Henry Houlden; Claudia Schulte; Manu Sharma; Abi Li; Daniela Berg; Anna Melchers; Reema Paudel; J Raphael Gibbs; Javier Simon-Sanchez; Coro Paisan-Ruiz; Jose Bras; Jinhui Ding; Honglei Chen; Bryan Joseph Traynor; Sampath Arepalli; Ryan R Zonozi; Tamas Revesz; Janice Holton; Nicholas W Wood; Andrew Lees; Wolfgang H Oertel; Ullrich Wüllner; Stefano Goldwurm; Maria Teresa Pellecchia; Thomas Illig; Olaf Riess; Hubert H Fernandez; Ramon L Rodriguez; Michael S Okun; Werner Poewe; Gregor K Wenning; John Hardy; Andrew Singleton; Francesca Del Sorbo; Susanne Schneider; Kailash P Bhatia; Thomas Gasser
SNCA variants are associated with increased risk for multiple system atrophy.
Annals of neurology 2009;65(5):610-4.
2009: Andrew J Duncan; Maria Bitner-Glindzicz; Brigitte Meunier; Harry Costello; Iain P Hargreaves; Luis Lopez; Michio Hirano; Catarina M Quinzii; Michael I Sadowski; John Hardy; Andrew Singleton; Peter T Clayton; Shamima Rahman
A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease.
American journal of human genetics 2009;84(5):558-66.
2009: John Hardy; Andrew Singleton
Genomewide association studies and human disease.
The New England journal of medicine 2009;360(17):1759-68.
2009: Sarah Teixeira Camargos; Leonardo Oliveira Dornas; Parastoo Momeni; Andrew J Lees; John Hardy; Andrew Singleton; Francisco Cardoso
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.
Movement disorders : official journal of the Movement Disorder Society 2009;24(5):662-6.
2009: Adriano Chiò; Jennifer C Schymick; Gabriella Restagno; Sonja W Scholz; Federica Lombardo; Shiao-Lin Lai; Gabriele Mora; Hon-Chung Fung; Angela Britton; Sampath Arepalli; J Raphael Gibbs; Michael Nalls; Stephen Berger; Lydia Coulter Kwee; Eugene Z Oddone; Jinhui Ding; Cynthia Crews; Ian Rafferty; Nicole Washecka; Dena Hernandez; Luigi Ferrucci; Stefania Bandinelli; Jack Guralnik; Fabio Macciardi; Federica Torri; Sara Lupoli; STEPHEN CHANOCK; Gilles Thomas; David J Hunter; Christian Gieger; H Erich Wichmann; Andrea Calvo; Roberto Mutani; Stefania Battistini; Fabio Giannini; Claudia Caponnetto; Giovanni Luigi Mancardi; Vincenzo La Bella; Francesca Valentino; Maria Rosaria Monsurrò; Gioacchino Tedeschi; Kalliopi Marinou; Mario Sabatelli; Amelia Conte; Jessica Mandrioli; Patrizia Sola; Fabrizio Salvi; Ilaria Bartolomei; Gabriele Siciliano; Cecilia Carlesi; Richard W Orrell; Kevin Talbot; Zachary Simmons; James Connor; Erik P Pioro; Travis Dunkley; Dietrich A Stephan; Dalia Kasperaviciute; Elizabeth M Fisher; Sibylle Jabonka; Michael Sendtner; Marcus Beck; Lucie Bruijn; Jeffrey rothstein; Silke Schmidt; Andrew Singleton; John Hardy; Bryan Joseph Traynor
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
Human molecular genetics 2009;18(8):1524-32.
2009: Jennifer A Webster; J Raphael Gibbs; Jennifer Clarke; Monika Ray; Weixiong Zhang; Peter Holmans; Kristen Rohrer; Alice Zhao; Lauren Marlowe; Mona Kaleem; Donald S McCorquodale; Cindy Cuello; Doris Leung; Leslie Bryden; Priti Nath; Victoria L Zismann; Keta Joshipura; Matthew Huentelman; Diane Hu-Lince; Keith D Coon; David Craig; John Pearson; Christopher B Heward; Eric Reiman; Dietrich A Stephan; John Hardy; Amanda Myers
Genetic control of human brain transcript expression in Alzheimer disease.
American journal of human genetics 2009;84(4):445-58.
2009: B Segarane; A Li; R Paudel; S Scholz; J Neumann; Andrew J Lees; Tamas Revesz; John Hardy; Christopher J Mathias; Nicholas W Wood; J Holton; Henry Houlden
Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy.
Neurology 2009;72(13):1185-6.
2009: Susanne A Schneider; Kailash P Bhatia; John Hardy
Complicated recessive dystonia parkinsonism syndromes.
Movement disorders : official journal of the Movement Disorder Society 2009;24(4):490-9.
2009: Kallirhoe Kalinderi; Sevasti Bostantjopoulou; Coro Paisan-Ruiz; Zoe Katsarou; John Hardy; Liana Fidani
Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Greece.
Neuroscience letters 2009;452(2):87-9.
2009: Michael A Nalls; Javier Simon-Sanchez; J Raphael Gibbs; Coro Paisan-Ruiz; Jose Tomas Bras; Toshiko Tanaka; Mar Matarin; Sonja Scholz; Charles Weitz; Tamara B Harris; Luigi Ferrucci; John Hardy; Andrew Singleton
Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics.
PLoS genetics 2009;5(3):e1000415.
2009: Parastoo Momeni; Alan Pittman; Tammaryn Lashley; Jana Vandrovcova; Elke Malzer; Connie Luk; Christine Hulette; Andrew J Lees; Tamas Revesz; John Hardy; Rohan de Silva
Clinical and pathological features of an Alzheimer's disease patient with the MAPT Delta K280 mutation.
Neurobiology of aging 2009;30(3):388-93.
2009: Lucy Huang; Yun Li; Andrew Singleton; John Hardy; Goncalo Abecasis; Noah A Rosenberg; Paul Scheet
Genotype-imputation accuracy across worldwide human populations.
American journal of human genetics 2009;84(2):235-50.
2009: Mindhu M Wickremaratchi; Elisa Majounie; Huw R Morris; Nigel M Williams; Helen Lewis; Steven S Gill; Sadaquate Khan; Peter Heywood; John Hardy; Charles M Wiles; Andrew Singleton; Niall Quinn
Parkin-related disease clinically diagnosed as a pallido-pyramidal syndrome.
Movement disorders : official journal of the Movement Disorder Society 2009;24(1):138-40.
2009: Elin S Blom; Vilmantas Giedraitis; Sampath Arepalli; Marian L Hamshere; Omanma Adighibe; Alison Goate; Julie Williams; Lars Lannfelt; John Hardy; Fabienne Wavrant-De Vrièze; Anna Glaser
Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs.
BMC medical genetics 2009;10():122.
2009: Wei Liu; Jinhui Ding; Jesse Raphael Gibbs; Sue Jane Wang; John Hardy; Andrew Singleton
A simple and efficient algorithm for genome-wide homozygosity analysis in disease.
Molecular systems biology 2009;5():304.
2009: Coro Paisan-Ruiz; Kailash P Bhatia; Abi Li; Dena Hernandez; Mary Davis; Nicholas W Wood; John Hardy; Henry Houlden; Andrew Singleton; Susanne A Schneider
Characterization of PLA2G6 as a locus for dystonia-parkinsonism.
Annals of neurology 2009;65(1):19-23.
2008: Jose Bras; Andrew Singleton; Mark Cookson; John Hardy
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.
The FEBS journal 2008;275(23):5767-73.
2008: Elin S Blom; Peter Holmans; Sampath Arepalli; Omanma Adighibe; Marian L Hamshere; Margaret Gatz; Nancy L Pedersen; A L Mina Bergem; Michael J Owen; Paul Hollingworth; Alison Goate; Julie Williams; Lars Lannfelt; John Hardy; Fabienne Wavrant-De Vrièze; Anna Glaser
Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(6):778-83.
2008: Michael C Zody; Zhaoshi Jiang; Hon-Chung Fung; Francesca Antonacci; LaDeana W Hillier; Maria Francesca Cardone; Tina A Graves; Jeffrey M Kidd; Ze Cheng; Amr Abouelleil; Lin Chen; John Wallis; Jarret Glasscock; Richard K Wilson; Amy Denise Reily; Jaime Duckworth; ventura Mario; John Hardy; Wesley C Warren; Evan E Eichler
Evolutionary toggling of the MAPT 17q21.31 inversion region.
Nature genetics 2008;40(9):1076-83.
2008: Mahim Jain; Deeann Wallis; Nathaniel H Robin; Fabienne Wavrant De Vrieze; John Hardy; Mohsen Ghadami; Kristin Bosse; Regina C Betz; Markus M Nöthen; Mauricio Arcos-Burgos; Maximilian Muenke
Locus homogeneity between syndactyly type 1A and craniosynostosis Philadelphia type?
American journal of medical genetics. Part A 2008;146A(17):2308-11.
2008: Terhi Peuralinna; M Oinas; Tuomo Polvikoski; Anders Paetau; Raimo Sulkava; Leena Niinistö; Hannu Kalimo; Dena Hernandez; John Hardy; Andrew Singleton; Pentti J Tienari; Liisa Myllykangas
Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.
Annals of neurology 2008;64(3):348-52.
2008: Helene Plun-Favreau; John Hardy
PINK1 in mitochondrial function.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11041-2.
2008: Rita Guerreiro; Isabel Santana; Jose Miguel Bras; Tamas Revesz; Olinda Rebelo; Maria Helena Ribeiro; Beatriz Santiago; Catarina Resende Oliveira; Andrew Singleton; John Hardy
Novel progranulin mutation: screening for PGRN mutations in a Portuguese series of FTD/CBS cases.
Movement disorders : official journal of the Movement Disorder Society 2008;23(9):1269-73.
2008: Ekaterina Rogaeva; John Hardy
Gaucher and Parkinson diseases: unexpectedly related.
Neurology 2008;70(24):2272-3.
2008: Mar Matarin; W Mark Brown; Andrew Singleton; John Hardy; James F Meschia
Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.
Stroke; a journal of cerebral circulation 2008;39(5):1586-9.
2008: Mar Matarin; Javier Simon-Sanchez; Hon-Chung Fung; Sonja Scholz; J Raphael Gibbs; Dena G Hernandez; Cynthia Crews; Angela Britton; Fabienne Wavrant De Vrieze; Thomas G Brott; Robert D Brown; Bradford Worrall; Scott Silliman; L Douglas Case; John Hardy; Stephen S Rich; James F Meschia; Andrew Singleton
Structural genomic variation in ischemic stroke.
Neurogenetics 2008;9(2):101-8.
2008: Jonathan D Rohrer; Jason D Warren; Rohani Omar; simon mead; Jonathan Beck; Tamas Revesz; Janice Holton; John M Stevens; Safa Al-Sarraj; Stuart M Pickering-Brown; John Hardy; Nick C Fox; John Collinge; Elizabeth K Warrington; Martin N Rossor
Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene.
Archives of neurology 2008;65(4):506-13.
2008: John Hardy; Nancy Low; Andrew Singleton
Whole genome association studies: deciding when persistence becomes perseveration.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(2):131-3.
2008: John Hardy; Andrew Singleton
The HapMap: charting a course for genetic discovery in neurological diseases.
Archives of neurology 2008;65(3):319-21.
2008: Sarah Camargos; Sonja Scholz; Javier Simón-Sánchez; Coro Paisan-Ruiz; Patrick Lewis; Dena Hernandez; Jinhui Ding; J Raphael Gibbs; Mark Cookson; Jose Bras; Rita Guerreiro; Catarina R Oliveira; Andrew J Lees; John Hardy; Francisco Cardoso; Andrew Singleton
DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA.
Lancet neurology 2008;7(3):207-15.
2008: Mattias Jakobsson; Sonja W Scholz; Paul Scheet; J Raphael Gibbs; Jenna M VanLiere; Hon-Chung Fung; Zachary A Szpiech; James H Degnan; Kai Wang; Rita Guerreiro; Jose M Bras; Jennifer C Schymick; Dena G Hernandez; Bryan Joseph Traynor; Javier Simon-Sanchez; Mar Matarin; Angela Britton; Joyce van de Leemput; Ian Rafferty; Maja Bucan; Howard M Cann; John Hardy; Noah A Rosenberg; Andrew Singleton
Genotype, haplotype and copy-number variation in worldwide human populations.
Nature 2008;451(7181):998-1003.
2008: Javier Simon-Sanchez; Sonja Scholz; Maria del Mar Matarin; Hon-Chung Fung; Dena Hernandez; J Raphael Gibbs; Angela Britton; John Hardy; Andrew Singleton
Genomewide SNP assay reveals mutations underlying Parkinson disease.
Human mutation 2008;29(2):315-22.
2008: A E Baum; Nirmala Akula; M Cabanero; I Cardona; Winston Corona; B Klemens; Thomas G. Schulze; Sven Cichon; Marcella Rietschel; Markus M Nöthen; Alexander Georgi; Johannes Schumacher; M Schwarz; Rami Abou Jamra; Susanne Höfels; Peter Propping; Jaya M Satagopan; Sevilla D Detera-Wadleigh; John Hardy; Francis McMajon
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
Molecular psychiatry 2008;13(2):197-207.
2008: Sarah Teixeira Camargos; Francisco Cardoso; Parastoo Momeni; Juliana Gurgel Gianetti; Andrew J Lees; John Hardy; Andrew Singleton
Novel GCH1 mutation in a Brazilian family with dopa-responsive dystonia.
Movement disorders : official journal of the Movement Disorder Society 2008;23(2):299-302.
2008: Njideka Okubadejo; Angela Britton; Cynthia Crews; Rufus Akinyemi; John Hardy; Andrew Singleton; Jose Bras
Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.
PloS one 2008;3(10):e3421.
2008: Mark Cookson; John Hardy; Patrick A Lewis
Genetic neuropathology of Parkinson's disease.
International journal of clinical and experimental pathology 2008;1(3):217-31.
2008: John Hardy; Katrina Gwinn-Hardy
The relationship between nosology, etiology and pathogenesis in neurodegenerative diseases.
Handbook of clinical neurology 2008;89():189-92.
2008: Rita Guerreiro; Jennifer C Schymick; Cynthia Crews; Andrew Singleton; John Hardy; Bryan Joseph Traynor
TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis.
PloS one 2008;3(6):e2450.
2008: Maarit Tanskanen; Terhi Peuralinna; Tuomo Polvikoski; Irma-Leena Notkola; Raimo Sulkava; John Hardy; Andrew Singleton; Sari Kiuru-Enari; Anders Paetau; Pentti J Tienari; Liisa Myllykangas
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study.
Annals of medicine 2008;40(3):232-9.
2008: Jose Bras; Rita Guerreiro; Maria Ribeiro; Ana Morgadinho; Cristina Januario; Margarida Dias; Ana Calado; Cristina Semedo; Catarina Oliveira; John Hardy; Andrew Singleton
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.
BMC neurology 2008;8():1.
2008: Jennifer A Webster; Amanda Myers; John Pearson; David Craig; Diane Hu-Lince; Keith D Coon; Victoria L Zismann; Thomas Beach; Doris Leung; Leslie Bryden; Rebecca F Halperin; Lauren Marlowe; Mona Kaleem; Matthew Huentelman; Keta Joshipura; Douglas G. Walker; Christopher B Heward; Rivka Ravid; Joseph Rogers; Andreas Papassotiropoulos; John Hardy; Eric Reiman; Dietrich A Stephan
Sorl1 as an Alzheimer's disease predisposition gene?
Neuro-degenerative diseases 2008;5(2):60-4.
2008: Mar Matarin; W Mark Brown; John Hardy; Stephen S Rich; Andrew Singleton; Robert D Brown; Thomas G Brott; Bradford Worrall; James F Meschia
Association of integrin alpha2 gene variants with ischemic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):81-9.
2007: Amanda Myers; J Raphael Gibbs; Jennifer A Webster; Kristen Rohrer; Alice Zhao; Lauren Marlowe; Mona Kaleem; Doris Leung; Leslie Bryden; Priti Nath; Victoria L Zismann; Keta Joshipura; Matthew Huentelman; Diane Hu-Lince; Keith D Coon; David Craig; John Pearson; Peter Holmans; Christopher B Heward; Eric Reiman; Dietrich A Stephan; John Hardy
A survey of genetic human cortical gene expression.
Nature genetics 2007;39(12):1494-9.
2007: Marian Hamshere; Peter Holmans; Dimitrios Avramopoulos; Susan S Bassett; Deborah Blacker; Lars Bertram; Howard Wiener; Nan Rochberg; Rudolph E Tanzi; Amanda Myers; Fabienne Wavrant-De Vrièze; Rodney Go; Daniele Fallin; Simon Lovestone; John Hardy; Alison Goate; Michael O'Donovan; Julie Williams; Michael J Owen
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease.
Human molecular genetics 2007;16(22):2703-12.
2007: David S Goldstein; Richard Imrich; Elizabeth Peckham; Courtney Holmes; G Lopez; C Crews; John Hardy; Andrew Singleton; Mark Hallett
Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.
Neurology 2007;69(16):1580-4.
2007: Paul Hollingworth; Marian Hamshere; Peter Holmans; Michael C O'Donovan; Rebecca Sims; John Powell; Simon Lovestone; Amanda Myers; FW DeVrieze; John Hardy; Alison Goate; Michael J Owen; Julie Williams
Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):841-8.
2007: Amalia C Bruni; Parastoo Momeni; L Bernardi; Carmine Tomaino; F Frangipane; Joshua Elder; Toshitaka Kawarai; Christine Sato; S Pradella; Yosuke Wakutani; M Anfossi; M Gallo; S Geracitano; A Costanzo; Nicoletta Smirne; S A M Curcio; Maria Mirabelli; Gianfranco Puccio; Rosanna Colao; Raffaele Maletta; A Kertesz; Peter St George-Hyslop; John Hardy; Ekaterina Rogaeva
Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation.
Neurology 2007;69(2):140-7.
2007: John Hardy; Andrew Singleton
Reporting and interpretation of genetic variants in cases and controls.
Neurology 2007;69(1):111-2.
2007: Liana Fidani; Jordi Clarimon; Antonis Goulas; Apostolos Hatzitolios; W Evans; E Tsirogianni; John Hardy; Alexandros Kotsis
Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2007;14(7):745-9.
2007: Jennifer C Schymick; Y Yang; Peter M Andersen; J P Vonsattel; Matthew J Greenway; Parastoo Momeni; Joshua Elder; Adriano Chio; Gabriella Restagno; Wim Robberecht; C Dahlberg; O Mukherjee; Alison Goate; N Graff-Radford; Richard Caselli; Michael Hutton; Jennifer Gass; A Cannon; Rosa Rademakers; Andrew Singleton; Orla Hardiman; Jeffrey rothstein; John Hardy; Bryan Joseph Traynor
Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes.
Journal of neurology, neurosurgery, and psychiatry 2007;78(7):754-6.
2007: Eric Reiman; Jennifer A Webster; Amanda Myers; John Hardy; Travis Dunkley; Victoria L Zismann; Keta D Joshipura; John Pearson; Diane Hu-Lince; Matthew Huentelman; David Craig; Keith D Coon; Winnie S Liang; RiLee H Herbert; Thomas Beach; Kristen C Rohrer; Alice S Zhao; Doris Leung; Leslie Bryden; Lauren Marlowe; Mona Kaleem; Diego Mastroeni; Andrew Grover; Christopher B Heward; Rivka Ravid; Joseph Rogers; Michael Hutton; Stacey Melquist; Ronald C. Petersen; Gene Alexander; Richard Caselli; Walter A Kukull; Andreas Papassotiropoulos; Dietrich A Stephan
GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
Neuron 2007;54(5):713-20.
2007: Antony E Shrimpton; Robert L Schelper; Reinhold P Linke; John Hardy; Richard Crook; dennis dickson; Takashi Ishizawa; Richard L Davis
A presenilin 1 mutation (L420R) in a family with early onset Alzheimer disease, seizures and cotton wool plaques, but not spastic paraparesis.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(3):228-32.
2007: Joyce van de Leemput; Jayanth Chandran; Melanie A Knight; Lynne A Holtzclaw; Sonja Scholz; Mark Cookson; Henry Houlden; Katrina Gwinn-Hardy; Hon-Chung Fung; Xian Lin; Dena Hernandez; Javier Simon-Sanchez; Nicholas W Wood; Paola Giunti; Ian Rafferty; John Hardy; Elsdon Storey; R J McKinlay Gardner; Susan M Forrest; Elizabeth M C Fisher; James T Russell; Huaibin Cai; Andrew Singleton
Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.
PLoS genetics 2007;3(6):e108.
2007: Kewie Chen; Eric Reiman; Gene Alexander; Richard Caselli; Richard Gerkin; Daniel Bandy; Alisa Domb; David Osborne; Nick C Fox; Bill Crum; Ann M Saunders; John Hardy
Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates.
The American journal of psychiatry 2007;164(6):916-21.
2007: Giancarlo V De Ferrari; Andreas Papassotiropoulos; Travis L Biechele; Fabienne Wavrant De-Vrieze; Miguel E Avila; Michael Ben Major; Amanda Myers; Katia Sáez; Juan P Henríquez; Alice Zhao; M Axel Wollmer; Roger M Nitsch; Christoph Hock; Christopher M Morris; John Hardy; Randall T Moon
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9434-9.
2007: Nancy C Low; John Hardy
What is a schizophrenic mouse?
Neuron 2007;54(3):348-9.
2007: Irene Litvan; Marie-Francoise Chesselet; Thomas Gasser; Donato A Di Monte; Davis Parker; Theo Hagg; John Hardy; Peter Jenner; Richard H Myers; Donald L Price; Mark Hallett; William J Langston; Anthony E Lang; Glenda Halliday; Walter Rocca; Charles Duyckaerts; dennis dickson; Yoav Ben-Shlomo; Christopher G Goetz; Eldad Melamed
The etiopathogenesis of Parkinson disease and suggestions for future research. Part II.
Journal of neuropathology and experimental neurology 2007;66(5):329-36.
2007: Mar Matarín; W Mark Brown; Sonja Scholz; Javier Simón-Sánchez; Hon-Chung Fung; Dena Hernandez; J Raphael Gibbs; Fabienne Wavrant De Vrieze; Cynthia Crews; Angela Britton; Carl D Langefeld; Thomas G Brott; Robert D Brown; Bradford Worrall; Michael R Frankel; Scott L Silliman; L Douglas Case; Andrew Singleton; John Hardy; Stephen S Rich; James F Meschia
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.
Lancet neurology 2007;6(5):414-20.
2007: Fabienne Wavrant-De Vrièze; Danielle Compton; Meridith Womick; Sampath Arepalli; Omanma Adighibe; Ling Li; Jordi Pérez-Tur; John Hardy
ABCA1 polymorphisms and Alzheimer's disease.
Neuroscience letters 2007;416(2):180-3.
2007: Keith D Coon; Amanda Myers; David Craig; Jennifer A Webster; John Pearson; Diane Hu Lince; Victoria L Zismann; Thomas Beach; Doris Leung; Leslie Bryden; Rebecca F Halperin; Lauren Marlowe; Mona Kaleem; Douglas G. Walker; Rivka Ravid; Christopher B Heward; Joseph Rogers; Andreas Papassotiropoulos; Eric Reiman; John Hardy; Dietrich A Stephan
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
The Journal of clinical psychiatry 2007;68(4):613-8.
2007: Irene Litvan; Glenda Halliday; Mark Hallett; Christopher G Goetz; Walter Rocca; Charles Duyckaerts; Yoav Ben-Shlomo; dennis dickson; Anthony E Lang; Marie-Francoise Chesselet; William J Langston; Donato A Di Monte; Thomas Gasser; Theo Hagg; John Hardy; Peter Jenner; Eldad Melamed; Richard H Myers; Davis Parker; Donald L Price
The etiopathogenesis of Parkinson disease and suggestions for future research. Part I.
Journal of neuropathology and experimental neurology 2007;66(4):251-7.
2007: Jennifer C Schymick; Sonja Scholz; Hon-Chung Fung; Angela Britton; Sampath Arepalli; J Raphael Gibbs; Federica Lombardo; Mar Matarin; Dalia Kasperaviciute; Dena G Hernandez; Cynthia Crews; Lucie Bruijn; Jeffrey rothstein; Gabriele Mora; Gabriella Restagno; Adriano Chio; Andrew Singleton; John Hardy; Bryan Joseph Traynor
Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data.
Lancet neurology 2007;6(4):322-8.
2007: Abraham M Brown; Derek Gordon; Hsinhwa Lee; Fabienne Wavrant-De Vrièze; Elena Cellini; Silvia Bagnoli; Benedetta Nacmias; Sandro Sorbi; John Hardy; John P Blass
Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.
Neurochemical research 2007;32(4-5):857-69.
2007: Bradford Worrall; Thomas G Brott; Robert D Brown; W Mark Brown; Stephen S Rich; Sampath Arepalli; Fabienne Wavrant-De Vrièze; Jaime Duckworth; Andrew Singleton; John Hardy; James F Meschia
IL1RN VNTR polymorphism in ischemic stroke: analysis in 3 populations.
Stroke; a journal of cerebral circulation 2007;38(4):1189-96.
2007: John Hardy
Does Abeta 42 have a function related to blood homeostasis?
Neurochemical research 2007;32(4-5):833-5.
2007: Carol F Lippa; J E Duda; Murray Grossman; Howard I Hurtig; Dag Aarsland; Bradley Boeve; David J Brooks; dennis dickson; Bruno Dubois; M Emre; Stanley Fahn; J M Farmer; Douglas Galasko; James E Galvin; Christopher G Goetz; John H Growdon; Katrina Gwinn-Hardy; John Hardy; Peter Heutink; Takeshi Iwatsubo; K Kosaka; Virginia M-Y Lee; James B Leverenz; Eliezer Masliah; Ian G McKeith; Robert L Nussbaum; C Warren Olanow; B M Ravina; Andrew Singleton; Caroline M Tanner; John Q Trojanowski; Zbigniew K Wszolek
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.
Neurology 2007;68(11):812-9.
2007: Amanda Myers; Alan Pittman; Alice S Zhao; Kristen Rohrer; Mona Kaleem; Lauren Marlowe; Andrew J Lees; Doris Leung; Ian G McKeith; Robert H Perry; Christopher M Morris; John Q Trojanowski; Christopher Clark; Jason H T Karlawish; Steven E Arnold; Mark S Forman; Vivianna M Van Deerlin; Rohan de Silva; John Hardy
The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.
Neurobiology of disease 2007;25(3):561-70.
2007: John Hardy; Amanda Myers
Genetic variability in expression of proteins and the risk of sporadic neurologic diseases.
Neurology 2007;68(9):632-3.
2007: Per-Gunnar Wiklund; W Mark Brown; Thomas G Brott; Birgitta Stegmayr; Robert D Brown; Sofie Nilsson-Ardnor; John Hardy; Brett Kissela; Andrew Singleton; Dan Holmberg; Stephen S Rich; James F Meschia
Lack of aggregation of ischemic stroke subtypes within affected sibling pairs.
Neurology 2007;68(6):427-31.
2007: John Hardy
Putting presenilins centre stage. Introduction to the Talking Point on the role of presenilin mutations in Alzheimer disease.
EMBO reports 2007;8(2):134-5.
2007: Katrina Gwinn-Hardy; roderick corriveau; Hiroshi Mitsumoto; Kate Bednarz; Robert H Brown; Merit E Cudkowicz; Paul H Gordon; John Hardy; Edward J Kasarskis; Petra Kaufmann; Robert Miller; Eric Sorenson; Rup Tandan; Bryan Joseph Traynor; Josefina Nash; Alex Sherman; Matthew D Mailman; James Ostell; Lucie Bruijn; Valerie Cwik; Stephen S Rich; Andrew Singleton; Larry Refolo; Jaime Andrews; Ran Zhang; Robin A Conwit; Margaret A Keller
Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.
PloS one 2007;2(12):e1254.
2007: Nancy C P Low; John Hardy
Psychiatric disorder criteria and their application to research in different racial groups.
BMC psychiatry 2007;7():1.
2007: Javier Simon-Sanchez; Sonja Scholz; Hon-Chung Fung; Mar Matarin; Dena Hernandez; J Raphael Gibbs; Angela Britton; Fabienne Wavrant De Vrieze; Elizabeth Peckham; Katrina Gwinn-Hardy; Anthony Crawley; Judith C Keen; Josefina Nash; Digamber Borgaonkar; John Hardy; Andrew Singleton
Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals.
Human molecular genetics 2007;16(1):1-14.
2006: Mark Cookson; John Hardy
The persistence of memory.
The New England journal of medicine 2006;355(25):2697-8.
2006: Parastoo Momeni; Jason Bell; Jaime Duckworth; Michael Hutton; D M A Mann; Stuart Pickering Brown; John Hardy
Sequence analysis of all identified open reading frames on the frontal temporal dementia haplotype on chromosome 3 fails to identify unique coding variants except in CHMP2B.
Neuroscience letters 2006;410(2):77-9.
2006: Hon-Chung Fung; Sonja Scholz; Mar Matarin; Javier Simón-Sánchez; Dena Hernandez; Angela Britton; J Raphael Gibbs; Carl Langefeld; Matt L Stiegert; Jennifer C Schymick; Michael S Okun; Ronald J Mandel; Hubert H Fernandez; Kelly D Foote; Ramón L Rodríguez; Elizabeth Peckham; Fabienne Wavrant De Vrieze; Katrina Gwinn-Hardy; John Hardy; Andrew Singleton
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.
Lancet neurology 2006;5(11):911-6.
2006: Mario Masellis; Parastoo Momeni; Wendy S Meschino; Reid Heffner; Joshua Elder; Christine Sato; Yan Liang; Peter St George-Hyslop; John Hardy; Juan Bilbao; Sandra Black; Ekaterina Rogaeva
Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome.
Brain : a journal of neurology 2006;129(Pt 11):3115-23.
2006: Jeffrey Seal; Michele C Gornick; Nitin Gogtay; Philip Shaw; Deanna Greenstein; M Coffey; Peter Gochman; T Stromberg; Z Chen; Barry Merriman; Stanley F Nelson; J Brooks; Sampath Arepalli; Fabienne Wavrant-De Vrièze; John Hardy; Judy Rapoport; Anjene Addington
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia.
Journal of medical genetics 2006;43(11):887-92.
2006: John Hardy
A hundred years of Alzheimer's disease research.
Neuron 2006;52(1):3-13.
2006: John Hardy; Huaiban Cai; Mark Cookson; Katrina Gwinn-Hardy; Andrew Singleton
Genetics of Parkinson's disease and parkinsonism.
Annals of neurology 2006;60(4):389-98.
2006: John Hardy
No definitive evidence for a role for the environment in the etiology of Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(10):1790-1.
2006: Omanma Adighibe; Sampath Arepalli; Jaime Duckworth; John Hardy; Fabienne Wavrant-De Vrièze
Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease.
Neurobiology of aging 2006;27(10):1431-4.
2006: John Hardy
Bad luck: an unappreciated limitation in the interpretation of twin studies.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(6):681.
2006: Edward D Huey; Jordan Grafman; Eric M Wassermann; Pietro Pietrini; Michael C Tierney; Bernardino Ghetti; Salvatore Spina; Matt Baker; Michael Hutton; Joshua W Elder; Stephen L Berger; Kyle A Heflin; John Hardy; Parastoo Momeni
Characteristics of frontotemporal dementia patients with a Progranulin mutation.
Annals of neurology 2006;60(3):374-80.
2006: Yonghong Li; Andrew Grupe; Charles Rowland; Petra Nowotny; John S K Kauwe; Scott Smemo; Anthony L Hinrichs; Kristina Tacey; Timothy A Toombs; Shirley Kwok; Joseph J Catanese; Thomas J White; Taylor J Maxwell; Paul Hollingworth; Richard Abraham; David C Rubinsztein; Carol Brayne; Fabienne Wavrant-De Vrièze; John Hardy; Michael O'Donovan; Simon Lovestone; John C Morris; Leon J Thal; Michael J Owen; Julie Williams; Alison Goate
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.
Human molecular genetics 2006;15(17):2560-8.
2006: Alexey Shatunov; Nyamkhishig Sambuughin; Joseph Jankovic; Randolph C Elble; Hee Suk Lee; Andrew Singleton; Ayush Dagvadorj; Jay Ji; Yiping Zhang; Virginia E Kimonis; John Hardy; Mark Hallett; Lev G Goldfarb
Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23.
Brain : a journal of neurology 2006;129(Pt 9):2318-31.
2006: John Hardy; Karen Cullen
Amyloid at the blood vessel wall.
Nature medicine 2006;12(7):756-7.
2006: Liana Fidani; Kallirhoe Kalinderi; Sevasti Bostantjopoulou; Jordi Clarimon; Antonis Goulas; Zoe Katsarou; John Hardy; Alexandros Kotsis
Association of the Tau haplotype with Parkinson's disease in the Greek population.
Movement disorders : official journal of the Movement Disorder Society 2006;21(7):1036-9.
2006: John Hardy; Harry Orr
The genetics of neurodegenerative diseases.
Journal of neurochemistry 2006;97(6):1690-9.
2006: Jordi Clarimon; Sonja Scholz; Hon-Chung Fung; John Hardy; Johanna Eerola; Olli Hellstrom; Chiung-Mei Chen; Yih-Ru Wu; Pentti J Tienari; Andrew Singleton
Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease.
American journal of human genetics 2006;78(6):1082-4; author reply 1092-4.
2006: Kathleen Ries Merikangas; Nancy C P Low; John Hardy
Commentary: understanding sources of complexity in chronic diseases--the importance of integration of genetics and epidemiology.
International journal of epidemiology 2006;35(3):590-2; discussion 593-6.
2006: Hon-Chung Fung; Chiung-Mei Chen; John Hardy; Dena Hernandez; Andrew Singleton; Yih-Ru Wu
Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(6):880-1.
2006: Terri Edwards-Lee; Johnny Wen; Jason Bell; John Hardy; Julia Chung; Parastoo Momeni
A presenilin-1 mutation (T245P) in transmembrane domain 6 causes early onset Alzheimer's disease.
Neuroscience letters 2006;398(3):251-2.
2006: Roneil Malkani; Ian D'Souza; Katrina Gwinn-Hardy; Gerard D Schellenberg; John Hardy; Parastoo Momeni
A MAPT mutation in a regulatory element upstream of exon 10 causes frontotemporal dementia.
Neurobiology of disease 2006;22(2):401-3.
2006: Parastoo Momeni; Nigel J Cairns; Robert H Perry; Eileen H Bigio; Marla Gearing; Andrew Singleton; John Hardy
Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID).
Neurobiology of aging 2006;27(5):778.e1-778.e6.
2006: John Hardy; Parastoo Momeni; Bryan Joseph Traynor
Frontal temporal dementia: dissecting the aetiology and pathogenesis.
Brain : a journal of neurology 2006;129(Pt 4):830-1.
2006: Hon-Chung Fung; Chiung-Mei Chen; John Hardy; Andrew Singleton; Guey-Jen Lee-Chen; Yih-Ru Wu
Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan.
Neuroscience letters 2006;394(1):33-6.
2006: John Hardy
Has the amyloid cascade hypothesis for Alzheimer's disease been proved?
Current Alzheimer research 2006;3(1):71-3.
2006: John Hardy; Sonja Scholz; Whitney Evans; Lev Goldfarb; Andrew Singleton
Prion genotypes in Central America suggest selection for the V129 allele.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(1):33-5.
2006: Hon-Chung Fung; Georgia Xiromerisiou; J Raphael Gibbs; Y R Wu; Johanna Eerola; Vanessa Gourbali; Olli Hellström; C M Chen; Jaime Duckworth; Alexandros Papadimitriou; Pentti J Tienari; Georgios M Hadjigeorgiou; John Hardy; Andrew Singleton
Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts.
Neuro-degenerative diseases 2006;3(6):327-33.
2006: Lauren Marlowe; Rita Peila; Kelly Suzanne Benke; John Hardy; Lon R White; Lenore J Launer; Amanda Myers
Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk.
Neuro-degenerative diseases 2006;3(6):320-6.
2006: Hon-Chung Fung; Chiung-Mei Chen; John Hardy; Andrew Singleton; Yih-Ru Wu
A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan.
BMC neurology 2006;6():47.
2006: Parastoo Momeni; Jennifer C Schymick; Shushant Jain; Mark Cookson; Nigel J Cairns; Elisa Greggio; Matthew J Greenway; Stephen Berger; Stuart Pickering-Brown; Adriano Chio; Hon-Chung Fung; David M Holtzman; Edward D Huey; Eric M Wassermann; Jennifer Adamson; Michael Hutton; Ekaterina Rogaeva; Peter St George-Hyslop; Jeffrey rothstein; Orla Hardiman; Jordan Grafman; Andrew Singleton; John Hardy; Bryan Joseph Traynor
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC neurology 2006;6():44.
2006: Parastoo Momeni; Ekaterina Rogaeva; Vivianna M Van Deerlin; Wuxing Yuan; Jordan Grafman; Michael Tierney; Edward D Huey; Jason Bell; Christopher M Morris; Rajesh N. Kalaria; Susan J van Rensburg; Dana J H Niehaus; F C V Potocnik; Toshitaka Kawarai; Shabnam Salehi-Rad; Christine Sato; Peter St George-Hyslop; John Hardy
Genetic variability in CHMP2B and frontotemporal dementia.
Neuro-degenerative diseases 2006;3(3):129-33.
2006: John Hardy
Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):151-3.
2006: Rita Guerreiro; Jose M Bras; Isabel Santana; Cristina Januario; Beatriz Santiago; Ana S Morgadinho; Maria H Ribeiro; John Hardy; Andrew Singleton; Catarina Oliveira
Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort.
BMC neurology 2006;6():24.
2006: Robert Müller; Ian Mellors; Berit Johannessen; Aasne K Aarsand; Paul Kiefer; John Hardy; Richard Kendall; Colin Stephen Scott
European multi-center evaluation of the Abbott Cell-Dyn sapphire hematology analyzer.
Laboratory hematology : official publication of the International Society for Laboratory Hematology 2006;12(1):15-31.
2006: John Hardy; Alan Pittman; Amanda Myers; Hon-Chung Fung; Rohan de Silva; Jaime Duckworth
Tangle diseases and the tau haplotypes.
Alzheimer disease and associated disorders 2006;20(1):60-2.
2006: Andrew Grupe; Yonghong Li; Charles Rowland; Petra Nowotny; Anthony L Hinrichs; Scott Smemo; John S K Kauwe; Taylor J Maxwell; Sara Cherny; Lisa Doil; Kristina Tacey; Ryan van Luchene; Amanda Myers; Fabienne Wavrant-De Vrièze; Mona Kaleem; Paul Hollingworth; Luke Jehu; Catherine Foy; Nicola Archer; Gillian Hamilton; Peter Holmans; Chris M Morris; Joseph Catanese; John Sninsky; Thomas J White; John Powell; John Hardy; Michael O'Donovan; Simon Lovestone; Lesley Jones; John C Morris; Leon J Thal; Michael J Owen; Julie Williams; Alison Goate
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
American journal of human genetics 2006;78(1):78-88.
2006: John Hardy
Amyloid double trouble.
Nature genetics 2006;38(1):11-2.
2006: Scott Smemo; Petra Nowotny; Anthony L Hinrichs; John S K Kauwe; Sara Cherny; Katherine Erickson; Amanda Myers; Mona Kaleem; Lauren Marlowe; Alison M Gibson; Paul Hollingworth; Michael C O'Donovan; Christopher M Morris; Peter Holmans; Simon Lovestone; John C Morris; Leon J Thal; Yonghong Li; Andrew Grupe; John Hardy; Michael J Owen; Julie Williams; Alison Goate
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.
Annals of neurology 2006;59(1):21-6.
2006: Michael L Garcia; Andrew Singleton; Dena Hernandez; Christopher M Ward; Crystal Evey; Peter A Sapp; John Hardy; Robert H Brown; Don W Cleveland
Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis.
Neurobiology of disease 2006;21(1):102-9.
2005: Ian G McKeith; dennis dickson; J Lowe; M Emre; John T O'Brien; H Feldman; Jeffrey L Cummings; J E Duda; Carol F Lippa; Elaine K Perry; Dag Aarsland; Heii Arai; Clive G Ballard; Bradley Boeve; David J Burn; D Costa; T Del Ser; Bruno Dubois; Douglas Galasko; S Gauthier; Christopher G Goetz; E Gomez-Tortosa; G Halliday; Lawrence A Hansen; John Hardy; Takeshi Iwatsubo; Rajesh N. Kalaria; Daniel Kaufer; R A Kenny; Amos D Korczyn; Kenji Kosaka; Virginia M-Y Lee; Andrew J Lees; I Litvan; E Londos; Oscar L Lopez; Satoshi Minoshima; Yoshikuni Mizuno; J A Molina; E B Mukaetova-Ladinska; Florence Pasquier; Robert H Perry; J B Schulz; John Q Trojanowski; Masahito Yamada
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology 2005;65(12):1863-72.
2005: Dena Hernandez; Coro Paisan-Ruiz; Anthony Crawley; Roneil Malkani; John Werner; Katrina Gwinn-Hardy; dennis dickson; Fabienne Wavrant DeVrieze; John Hardy; Andrew Singleton
The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases.
Neuroscience letters 2005;389(3):137-9.
2005: Joy R Ross; Katherine Goller; John Hardy; Julia Riley; Karen Broadley; R A'hern; John Williams
Gabapentin is effective in the treatment of cancer-related neuropathic pain: a prospective, open-label study.
Journal of palliative medicine 2005;8(6):1118-26.
2005: Jose Miguel Bras; Rita Guerreiro; Maria Helena Ribeiro; Cristina Januario; Ana Morgadinho; Catarina R Oliveira; Luis Cunha; John Hardy; Andrew Singleton
G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort.
Movement disorders : official journal of the Movement Disorder Society 2005;20(12):1653-5.
2005: Parastoo Momeni; Chin-Song Lu; Yah-Huei Wu Chou; Hsiu-Chen Chang; Rou-Shayn Chen; Chiung Chu Chen; Jin-Tian Hsu; Andrew Singleton; John Hardy
Taiwanese cases of SCA2 are derived from a single founder.
Movement disorders : official journal of the Movement Disorder Society 2005;20(12):1633-6.
2005: Debomoy K Lahiri; Yuan-Wen Ge; Bryan Maloney; Fabienne Wavrant-De Vrièze; John Hardy
Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease.
Neurobiology of aging 2005;26(10):1329-41.
2005: Alan Pittman; Amanda Myers; Patrick M Abou-Sleiman; Hon-Chung Fung; Mona Kaleem; Lauren Marlowe; Jaime Duckworth; Doris Leung; D Williams; Linda Kilford; N Thomas; Christopher M Morris; dennis dickson; Nicholas W Wood; John Hardy; Andrew J Lees; Rohan de Silva
Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration.
Journal of medical genetics 2005;42(11):837-46.
2005: Allen Mao; Vladislava Paharkova-Vatchkova; John Hardy; Marcia Miller; Susan Kovats
Estrogen selectively promotes the differentiation of dendritic cells with characteristics of Langerhans cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5146-51.
2005: Kavon Rezai-Zadeh; Doug Shytle; Nan Sun; Takashi Mori; Huayan Hou; Deborah Jeanniton; Jared Ehrhart; Kirk Townsend; Jin Zeng; Dave Morgan; John Hardy; Terrence Town; Jun Tan
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(38):8807-14.
2005: Liisa Myllykangas; Fabienne Wavrant-De Vrièze; Tuomo Polvikoski; Irma-Leena Notkola; Raimo Sulkava; Leena Niinistö; Steven D Edland; Sampath Arepalli; Omanma Adighibe; Danielle Compton; John Hardy; Matti Haltia; Pentti J Tienari
Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.
Journal of the neurological sciences 2005;236(1-2):17-24.
2005: James F Meschia; Thomas G Brott; Robert D Brown; Richard Crook; Bradford Worrall; Brett Kissela; W Mark Brown; Stephen S Rich; L Douglas Case; E Whitney Evans; Stephen Hague; Andrew Singleton; John Hardy
Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.
Annals of neurology 2005;58(3):351-61.
2005: Y Li; Charles Rowland; Kristina Tacey; Joseph J Catanese; John J Sninsky; John Hardy; J Powell; Simon Lovestone; John C Morris; Leon J Thal; Alison Goate; Michael J Owen; Julie Williams; Andrew Grupe
The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples.
Molecular psychiatry 2005;10(9):809-10.
2005: Amanda Myers; Mona Kaleem; Lauren Marlowe; Alan Pittman; Andrew J Lees; Hon-Chung Fung; Jaime Duckworth; Doris Leung; A Gibson; Christopher M Morris; Rohan de Silva; John Hardy
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.
Human molecular genetics 2005;14(16):2399-404.
2005: John Hardy; Andrew J Lees
Parkinson's disease: a broken nosology.
Movement disorders : official journal of the Movement Disorder Society 2005;20 Suppl 12():S2-4.
2005: Samir Kumar-Singh; Daniel Pirici; Eileen McGowan; Sally Serneels; Chantal Ceuterick; John Hardy; karen duff; dennis dickson; Christine Van Broeckhoven
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.
The American journal of pathology 2005;167(2):527-43.
2005: John Hardy; Alan Pittman; Amanda Myers; Katrina Gwinn-Hardy; Hon-Chung Fung; Rohan de Silva; Michael Hutton; Jaime Duckworth
Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens.
Biochemical Society transactions 2005;33(Pt 4):582-5.
2005: John Hardy
Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration.
Biochemical Society transactions 2005;33(Pt 4):578-81.
2005: Eileen McGowan; Fiona Pickford; Jungsu Kim; Luisa Onstead; Jason Eriksen; Cindy Yu; Lisa Skipper; Michael Murphy; Jenny Beard; Pritam Das; Karen Jansen; Michael W DeLucia; Wen-Lang Lin; Georgia Dolios; Rong Wang; Christopher B Eckman; dennis dickson; Michael Hutton; John Hardy; todd golde
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Neuron 2005;47(2):191-9.
2005: Maria Martinez; Alexis Brice; Jenny R Vaughan; Alexander Zimprich; Monique Breteler; Giuseppe Meco; Alessandro Filla; Matthew J Farrer; Christine Bétard; Andrew Singleton; John Hardy; Giuseppe De Michele; Vincenzo Bonifati; Ben A Oostra; Thomas Gasser; Nicholas W Wood; Alexandra Dürr
Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):72-4.
2005: Petra Nowotny; Anthony L Hinrichs; Scott Smemo; John S K Kauwe; Taylor Maxwell; Peter Holmans; Marian Hamshere; Darko Turic; Luke Jehu; Paul Hollingworth; Pamela Moore; Leslie Bryden; Amanda Myers; Lisa M Doil; Kristina M Tacey; Alison M Gibson; Ian G McKeith; Robert H Perry; Christopher M Morris; Leon J Thal; John C Morris; Michael C O'Donovan; Simon Lovestone; Andrew Grupe; John Hardy; Michael J Owen; Julie Williams; Alison Goate
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):62-8.
2005: Eric Reiman; Kewie Chen; Gene Alexander; Richard Caselli; Daniel Bandy; David Osborne; Ann M Saunders; John Hardy
Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8299-302.
2005: Peter Holmans; Marian Hamshere; Paul Hollingworth; Frances Rice; Nigel Tunstall; Sue Jones; Pamela Moore; Fabienne Wavrant DeVrieze; Amanda Myers; Richard Crook; Danielle Compton; Helen Marshall; David Meyer; Shantia Shears; Jeremy Booth; Dzanan Ramic; Nigel Williams; Nadine Norton; Richard Abraham; Pat Kehoe; Hywel Williams; Varuni Rudrasingham; Michael O'Donovan; Lesley Jones; John Hardy; Alison Goate; Simon Lovestone; Michael J Owen; Julie Williams
Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;135B(1):24-32.
2005: Jordi Clarimon; Hilmir Asgeirsson; Andrew Singleton; Finnbogi Jakobsson; Haukur Hjaltason; John Hardy; Sigurlaug Sveinbjornsdottir
Torsin A haplotype predisposes to idiopathic dystonia.
Annals of neurology 2005;57(5):765-7.
2005: Aaron J Bobb; Anjene Addington; Ellen Sidransky; Michele C Gornick; Jason P Lerch; Deanna Greenstein; Liv S Clasen; Wendy S Sharp; Gale Inoff-Germain; Fabienne Wavrant-De Vrièze; Mauricio Arcos-Burgos; Richard E Straub; John Hardy; F Xavier Castellanos; Judy Rapoport
Support for association between ADHD and two candidate genes: NET1 and DRD1.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;134B(1):67-72.
2005: Hon-Chung Fung; Jessica Evans; Whitney Evans; Jaime Duckworth; Alan Pittman; Rohan de Silva; Amanda Myers; John Hardy
The architecture of the tau haplotype block in different ethnicities.
Neuroscience letters 2005;377(2):81-4.
2005: James F Meschia; Thomas G Brott; Robert D Brown; Brett Kissela; John Hardy; W Mark Brown; Stephen S Rich
Correlation of proband and sibling stroke latency: the SWISS Study.
Neurology 2005;64(6):1061-3.
2005: Yonghong Li; Paul Hollingworth; Pamela Moore; Catherine Foy; Nicola Archer; John Powell; Petra Nowotny; Peter Holmans; Michael O'Donovan; Kristina Tacey; Lisa Doil; Ryan van Luchene; Veronica Garcia; Charles Rowland; Kit Lau; Joseph Cantanese; John J Sninsky; John Hardy; Leon J Thal; John C Morris; Alison Goate; Simon Lovestone; Michael J Owen; Julie Williams; Andrew Grupe
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.
Human mutation 2005;25(3):270-7.
2005: David W Miller; Anthony Crawley; Katrina Gwinn-Hardy; Grisel Lopez; Robert L Nussbaum; Mark Cookson; Andrew Singleton; John Hardy; Okan Dogu
Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.
Neuroscience letters 2005;374(3):189-91.
2005: Jordi Clarimon; Janel Johnson; Okan Dogu; Wagner Horta; Naheed Khan; Andrew J Lees; John Hardy; Andrew Singleton
Defining the ends of Parkin exon 4 deletions in two different families with Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;133B(1):120-3.
2005: T Edwards-Lee; John M Ringman; J Chung; John S Werner; A Morgan; Peter St George-Hyslop; P Thompson; R Dutton; A Mlikotic; E Rogaeva; John Hardy
An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.
Neurology 2005;64(2):377-9.
2005: Andreas Papassotiropoulos; jean-charles lambert; Fabienne Wavrant-De Vrièze; M Axel Wollmer; Heinz von der Kammer; Johannes R Streffer; Alessia Maddalena; Kim-Dung Huynh; Sibylle Wolleb; Dieter Lutjohann; Brigitte Schneider; Dietmar R Thal; Luigi M E Grimaldi; Magdalini Tsolaki; Elisabeth Kapaki; Rivka Ravid; Uwe Konietzko; Thomas Hegi; Thomas Pasch; Hans Jung; Heiko Braak; Philippe Amouyel; Evgeny I Rogaev; John Hardy; Christoph Hock; Roger M Nitsch
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.
Neuro-degenerative diseases 2005;2(5):233-41.
2005: Aideen McInerney-Leo; Donald W Hadley; Katrina Gwinn-Hardy; John Hardy
Genetic testing in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2005;20(1):1-10.
2004: Ekaterina Rogaeva; Janel Johnson; Anthony E Lang; Cindy Gulick; Katrina Gwinn-Hardy; Toshitaka Kawarai; Christine Sato; Angharad Morgan; John Werner; Robert L Nussbaum; Agnes Petit; Michael S Okun; Aideen McInerney; Ronald Mandel; Justus L Groen; Hubert H Fernandez; Ronald B Postuma; Kelly D Foote; Shabnam Salehi-Rad; Yan Liang; Sharon Reimsnider; Anurag Tandon; John Hardy; Peter St George-Hyslop; Andrew Singleton
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.
Archives of neurology 2004;61(12):1898-904.
2004: Huw R Morris; John C Steele; Richard Crook; Fabienne Wavrant-De Vrièze; Luisa Onstead-Cardinale; Katrina Gwinn-Hardy; Nicholas W Wood; Matthew J Farrer; Andrew J Lees; Patrick L McGeer; Teepu Siddique; John Hardy; Jordi Perez-Tur
Genome-wide analysis of the parkinsonism-dementia complex of Guam.
Archives of neurology 2004;61(12):1889-97.
2004: Maria Martinez; Alexis Brice; Jenny R Vaughan; Alexander Zimprich; Monique Breteler; Giuseppe Meco; Alessandro Filla; Matthew J Farrer; Christine Bétard; John Hardy; Giuseppe De Michele; Vincenzo Bonifati; Ben A Oostra; Thomas Gasser; Nicholas W Wood; Alexandra Dürr
Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease.
Journal of medical genetics 2004;41(12):900-7.
2004: J Busby; Kirsty K O'Brien; Alison M Gibson; Ian G McKeith; Robert H Perry; John Hardy; Andrew Singleton; Christopher M Morris
Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene.
Neurogenetics 2004;5(4):251-2.
2004: Abraham M Brown; Derek Gordon; Hsinhwa Lee; Michael Caudy; John Hardy; Vahram Haroutunian; John P Blass
Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;131B(1):60-6.
2004: Yonghong Li; Petra Nowotny; Peter Holmans; Scott Smemo; John S K Kauwe; Anthony L Hinrichs; Kristina Tacey; Lisa Doil; Ryan van Luchene; Veronica Garcia; Charles Rowland; Steve Schrodi; Diane Leong; Goran Gogic; Joanne Chan; Anibal Cravchik; David Ross; Kit Lau; Shirley Kwok; Sheng-Yung Chang; Joe Catanese; John Sninsky; Thomas J White; John Hardy; John Powell; Simon Lovestone; John C Morris; Leon J Thal; Michael J Owen; Julie Williams; Alison Goate; Andrew Grupe
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15688-93.
2004: Melissa Hanson; Melissa Honour; Amanda Singleton; Anthony Crawley; Andrew Singleton; John Hardy; Katrina Gwinn-Hardy
Analysis of familial and sporadic restless legs syndrome in age of onset, gender, and severity features.
Journal of neurology 2004;251(11):1398-401.
2004: John Hardy
Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer's disease in vivo?
European journal of nuclear medicine and molecular imaging 2004;31(11):1539-40.
2004: Whitney Evans; Hon-Chung Fung; John Steele; Johanna Eerola; Pentti J Tienari; Alan Pittman; Rohan de Silva; Amanda Myers; Fabienne Wavrant-De Vrieze; Andrew Singleton; John Hardy
The tau H2 haplotype is almost exclusively Caucasian in origin.
Neuroscience letters 2004;369(3):183-5.
2004: Virgilio Gerald H Evidente; Raymund P Esteban; Jose Luis Hernandez; Filipinas F Natividad; Joel Advincula; Katrina Gwinn-Hardy; John Hardy; Andrew Singleton; Andrew Singleton
Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study.
Parkinsonism & related disorders 2004;10(7):407-10.
2004: John Hardy; J William Langston
How many pathways are there to nigral death?
Annals of neurology 2004;56(3):316-8.
2004: Bengt Winblad; K Palmer; Miia Kivipelto; Vesna Jelic; Laura Fratiglioni; Lars-Olof Wahlund; agneta nordberg; Lars Bäckman; Marilyn S Albert; O Almkvist; Hiroyuki Arai; Hans Basun; Kaj Blennow; Mony J de Leon; Charles DeCarli; Timo Erkinjuntti; Ezio Giacobini; C Graff; John Hardy; C Jack; A Jorm; K Ritchie; C.M. Duijn; P Visser; Ronald C. Petersen
Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.
Journal of internal medicine 2004;256(3):240-6.
2004: Yonghong Li; Kristina Tacey; Lisa Doil; Ryan van Luchene; Veronica Garcia; Charles Rowland; Steven J Schrodi; Diane Leong; Kit Lau; Joseph J Catanese; John J Sninsky; Petra Nowotny; Peter Holmans; John Hardy; John Powell; Simon Lovestone; Leon J Thal; Michael J Owen; Julie Williams; Alison Goate; Andrew Grupe
Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.
Neuroscience letters 2004;366(3):268-71.
2004: Janel Johnson; Stephen Hague; Melissa Hanson; A Gibson; K E Wilson; E Whitney Evans; Amanda Adam Singleton; Aideen McInerney-Leo; Robert L Nussbaum; Dena G Hernandez; Marisol Gallardo; Ian G McKeith; David J Burn; M Ryu; O Hellstrom; Bernard Ravina; Johanna Eerola; Robert H Perry; E Jaros; Pentti J Tienari; Roberto Weiser; Katrina Gwinn-Hardy; Christopher M Morris; John Hardy; Andrew Singleton
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
Neurology 2004;63(3):554-6.
2004: Paul D. Coleman; Roger Kurlan; Richard Crook; John S Werner; John Hardy
A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5.
Neuroscience letters 2004;364(3):139-40.
2004: Okan Dogu; Janel Johnson; Dena Hernandez; Melissa Hanson; John Hardy; Hülya Apaydin; Sibel Ozekmekçi; Serhan Sevim; Katrina Gwinn-Hardy; Andrew Singleton
A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion.
Movement disorders : official journal of the Movement Disorder Society 2004;19(7):812-6.
2004: Lorraine N Clark; Shehla Afridi; Helen Mejia-Santana; Juliette Harris; Elan D Louis; Lucien J Cote; Howard Andrews; Andrew Singleton; Fabienne Wavrant De-Vrieze; John Hardy; Richard Mayeux; Stanley Fahn; Cheryl Waters; Blair Ford; Steven Frucht; Ruth Ottman; Karen Marder
Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.
Movement disorders : official journal of the Movement Disorder Society 2004;19(7):796-800.
2004: John Hardy
The uncertain anatomy of Alzheimer's disease.
Neurobiology of aging 2004;25(6):719-20; discussion 743-6.
2004: Alan Pittman; Amanda Myers; Jaime Duckworth; Leslie Bryden; Melissa Hanson; Patrick M Abou-Sleiman; Nicholas W Wood; John Hardy; Andrew J Lees; Rohan de Silva
The structure of the tau haplotype in controls and in progressive supranuclear palsy.
Human molecular genetics 2004;13(12):1267-74.
2004: Janel Johnson; Jovanka Ostojic; Lars Lannfelt; Anna Glaser; Hans Basun; Ekaterina Rogaeva; Toshitaka Kawarai; Amalia Bruni; Peter St George-Hyslop; Alison Goate; Pau Pastor; Sumi Chakraverty; Joanne Norton; John C Morris; John Hardy; Andrew Singleton
No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.
Neuroscience letters 2004;363(2):99-101.
2004: Joseph Wiley; Timothy Lynch; Sarah J Lincoln; Lisa Skipper; Mary Hulihan; David Gosal; Gina Bisceglio; Jennifer Kachergus; John Hardy; Matthew J Farrer
Parkinson's disease in Ireland: clinical presentation and genetic heterogeneity in patients with parkin mutations.
Movement disorders : official journal of the Movement Disorder Society 2004;19(6):677-81.
2004: Sarah Furtado; Haydeh Payami; Paul J Lockhart; Melissa Hanson; John G Nutt; Amanda Adam Singleton; Amanda Singleton; Jamel Bower; Ryan J Utti; Thomas D Bird; Raul de la Fuente-Fernandez; Yoshio Tsuboi; Mary L Klimek; Oksana Suchowersky; John Hardy; Donald B Calne; Zbigniew K Wszolek; Matthew J Farrer; Katrina Gwinn-Hardy; A Jon Stoessl
Profile of families with parkinsonism-predominant spinocerebellar ataxia type 2 (SCA2).
Movement disorders : official journal of the Movement Disorder Society 2004;19(6):622-9.
2004: Cesare M N Terracciano; John Hardy; Emma J Birks; Asghar Khaghani; N R Banner; M H Yacoub
Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy.
Circulation 2004;109(19):2263-5.
2004: Andrew Singleton; Amanda Myers; John Hardy
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases.
Human molecular genetics 2004;13 Spec No 1():R123-6.
2004: Leonard Petrucelli; dennis dickson; Kathryn Kehoe; Julie Taylor; Heather Snyder; Andrew Grover; Michael De Lucia; Eileen McGowan; Jada Lewis; Guy Prihar; Jungsu Kim; Wolfgang H Dillmann; Susan E Browne; Alexis Hall; Richard Voellmy; Yoshio Tsuboi; Ted M Dawson; Benjamin Wolozin; John Hardy; Michael Hutton
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
Human molecular genetics 2004;13(7):703-14.
2004: Andrew Singleton; Katrina Gwinn-Hardy; Yehonatan Sharabi; Sheng-Ting Li; Courtney Holmes; Raghuveer Dendi; John Hardy; Andrew Singleton; Anthony Crawley; David S Goldstein
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.
Brain : a journal of neurology 2004;127(Pt 4):768-72.
2004: Liana Fidani; Antonis Goulas; Richard Crook; Ronald C. Petersen; Eric G Tangalos; Alexandros Kotsis; John Hardy
An association study of the cholesteryl ester transfer protein TaqI B polymorphism with late onset Alzheimer's disease.
Neuroscience letters 2004;357(2):152-4.
2004: Julia Kirshner; John Hardy; Sharon P Wilczynski; John E Shively
Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1 integrin in a 3D model of morphogenesis.
Journal of molecular histology 2004;35(3):287-99.
2004: Stuart Pickering-Brown; Matt Baker; Thomas D Bird; John Q Trojanowski; Virginia M-Y Lee; Huw Morris; Martin N Rossor; John C Janssen; David Neary; David Craufurd; Anna Richardson; Julie Snowden; John Hardy; D M A Mann; Michael Hutton
Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;125B(1):79-82.
2004: Rina Bandopadhyay; Ann E Kingsbury; Mark Cookson; Andrew R Reid; Ian Evans; Andrew D Hope; Alan Pittman; Tammaryn Lashley; Canet Rosa; David W Miller; Chris McLendon; Catherine Strand; Andrew J Leonard; Patrick M Abou-Sleiman; Daniel G Healy; Hiroyashi Ariga; Nicholas W Wood; Rohan de Silva; Tamas Revesz; John Hardy; Andrew J Lees
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.
Brain : a journal of neurology 2004;127(Pt 2):420-30.
2004: Eric Reiman; Kewie Chen; Gene Alexander; Richard Caselli; Daniel Bandy; David Osborne; Ann M Saunders; John Hardy
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):284-9.
2004: Christian Pifl; Maya Khorchide; Alexandra Kattinger; Harald Reither; John Hardy; Oleh Hornykiewicz
alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.
Neuroscience letters 2004;354(1):34-7.
2004: John Hardy; Amanda Myers; Fabienne Wavrant De-Vrieze
Problems and solutions in the genetic analysis of late-onset Alzheimer's disease.
Neuro-degenerative diseases 2004;1(4-5):213-7.
2004: Victoria Busby; Steven Goossens; Petra Nowotny; Gillian Hamilton; Scott Smemo; Denise Harold; Dragana Turic; Luke Jehu; Amanda Myers; Meredith Womick; Daniel Woo; Danielle Compton; Lisa M Doil; Kristina M Tacey; Kit F Lau; Safa Al-Saraj; Richard Killick; Stuart Pickering-Brown; Pamela Moore; Paul Hollingworth; Nicola Archer; Catherine Foy; Sarah Walter; Corrine Lendon; Takeshi Iwatsubo; John C Morris; Joanne Norton; D M A Mann; Barbara Janssens; John Hardy; Michael O'Donovan; Lesley Jones; Julie Williams; Peter Holmans; Michael J Owen; Andrew Grupe; John Powell; Jolanda van Hengel; Alison Goate; Frans Van Roy; Simon Lovestone
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Neuromolecular medicine 2004;5(2):133-46.
2004: John Hardy
Toward Alzheimer therapies based on genetic knowledge.
Annual review of medicine 2004;55():15-25.
2004: Alexander Zimprich; Bertram Müller-Myhsok; Matthew J Farrer; Petra Leitner; Manu Sharma; Mary Hulihan; Paul Lockhart; Audrey Strongosky; Jennifer Kachergus; Donald B Calne; Jon Stoessl; Ryan Uitti; Ronald F Pfeiffer; Claudia Trenkwalder; Nikolaus Homann; Erwin Ott; Karoline Wenzel; Friedrich Asmus; John Hardy; Zbigniew K Wszolek; Thomas Gasser
The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.
American journal of human genetics 2004;74(1):11-9.
2004: Amanda Myers; Helen Marshall; Peter Holmans; Danielle Compton; Richard Crook; adrian mander; Petra Nowotny; Scott Smemo; Melanie Dunstan; Luke Jehu; Jen C Wang; Marian Hamshere; John C Morris; Joanne Norton; Sumi Chakraventy; Nigel Tunstall; Simon Lovestone; Ronald C. Petersen; Michael O'Donovan; Lesley Jones; Julie Williams; Michael J Owen; John Hardy; Alison Goate
Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;124B(1):29-37.
2003: Christopher M Morris; Kirsty K O'Brien; Alison M Gibson; John Hardy; Andrew Singleton
Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease.
Neuroscience letters 2003;352(2):151-3.
2003: Henry Houlden; Sarah J Lincoln; Matthew J Farrer; P G Cleland; John Hardy; Richard W Orrell
Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic.
Neurology 2003;61(10):1423-6.
2003: Sarah J Lincoln; Demetrius M Maraganore; Timothy G Lesnick; Rebecca Bounds; Mariza de Andrade; James H Bower; John Hardy; Matthew J Farrer
Parkin variants in North American Parkinson's disease: cases and controls.
Movement disorders : official journal of the Movement Disorder Society 2003;18(11):1306-11.
2003: Demetrius M Maraganore; Matthew J Farrer; Timothy G Lesnick; Mariza de Andrade; James H Bower; Dena Hernandez; John Hardy; Walter A Rocca
Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2003;18(11):1233-9.
2003: Andrew B Singleton; Matthew J Farrer; Janel Johnson; Andrew Singleton; Stephen Hague; Jennifer Kachergus; Mary Hulihan; Terhi Peuralinna; A Dutra; Robert L Nussbaum; Sarah J Lincoln; Anthony Crawley; Melissa Hanson; Demetrius M Maraganore; Charles H Adler; Mark Cookson; MD Muenter; Melisa J Baptista; D Miller; J Blancato; John Hardy; Katrina Gwinn-Hardy
alpha-Synuclein locus triplication causes Parkinson's disease.
Science (New York, N.Y.) 2003;302(5646):841.
2003: Johanna Eerola; D Hernandez; Jyrki Launes; Olli Hellström; Stephen Hague; Cindy Gulick; Janel Johnson; Terhi Peuralinna; John Hardy; Pentti J Tienari; Andrew Singleton
Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD.
Neurology 2003;61(7):1000-2.
2003: Omar M A El-Agnaf; Sultan A Salem; Katerina E Paleologou; Leanne J Cooper; Nigel J Fullwood; Mark J Gibson; Martin D Curran; Jennifer A Court; D M A Mann; Shu-ichi Ikeda; Mark Cookson; John Hardy; David Allsop
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1945-7.
2003: John Hardy
Impact of genetic analysis on Parkinson's disease research.
Movement disorders : official journal of the Movement Disorder Society 2003;18 Suppl 6():S96-8.
2003: Thomas G. Schulze; John Hardy; Francis McMajon
Inconsistent designs of association studies: a missed opportunity.
Molecular psychiatry 2003;8(9):770-2.
2003: Stephen Hague; Ekaterina Rogaeva; Dena Hernandez; Cindy Gulick; Andrew Singleton; Melissa Hanson; Janel Johnson; Roberto Weiser; Marisol Gallardo; Bernard Ravina; Katrina Gwinn-Hardy; Anthony Crawley; Peter St George-Hyslop; Anthony E Lang; Peter Heutink; Vincenzo Bonifati; John Hardy; Andrew Singleton
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation.
Annals of neurology 2003;54(2):271-4.
2003: John Hardy
Alzheimer's disease: genetic evidence points to a single pathogenesis.
Annals of neurology 2003;54(2):143-4.
2003: Dena Hernandez; Melissa Hanson; Andrew Singleton; Katrina Gwinn-Hardy; Jason Freeman; Bernard Ravina; Dana Doheny; Marisol Gallardo; Roberto Weiser; John Hardy; Andrew Singleton
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Parkinsonism & related disorders 2003;9(6):317-20.
2003: Denise Harold; Tim Peirce; Valentina Moskvina; Amanda Myers; Susan Jones; Paul Hollingworth; Pamela Moore; Simon Lovestone; John Powell; Catherine Foy; Nicola Archer; Sarah Walter; Amanda Edmonson; Stephen McIlroy; David Craig; Peter Passmore; Alison Goate; John Hardy; Michael O'Donovan; Julie Williams; Malcolm Liddell; Michael J Owen; Lesley Jones
Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease.
Human genetics 2003;113(3):258-67.
2003: James F Meschia; Thomas G Brott; Robert D Brown; Richard Crook; Michael R Frankel; John Hardy; José G Merino; Stephen S Rich; Scott L Silliman; Bradford Worrall
The Ischemic Stroke Genetics Study (ISGS) Protocol.
BMC neurology 2003;3():4.
2003: James F Meschia; Elizabeth J Atkinson; Peter C O'Brien; Thomas G Brott; Robert D Brown; John Hardy
Familial clustering of stroke according to proband age at onset of presenting ischemic stroke.
Stroke; a journal of cerebral circulation 2003;34(7):e89-91.
2003: Louis Tan ; Caroline M Tanner; Rong Chen; Piu Chan; Matthew J Farrer; John Hardy; J William Langston
Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutation.
Movement disorders : official journal of the Movement Disorder Society 2003;18(7):758-63.
2003: Richard A Frank; Douglas Galasko; Harald Hampel; John Hardy; Mony J de Leon; Pankaj D Mehta; Joseph Rogers; Eric Siemers; John Q Trojanowski
Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease.
Neurobiology of aging 2003;24(4):521-36.
2003: Laura Marlow; Canet Rosa; Sharie J Haugabook; John Hardy; Debomoy K Lahiri; Kumar Sambamurti
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Biochemical and biophysical research communications 2003;305(3):502-9.
2003: John Hardy
The relationship between Lewy body disease, Parkinson's disease, and Alzheimer's disease.
Annals of the New York Academy of Sciences 2003;991():167-70.
2003: Gregory A Rippon; Richard Crook; Matthew Baker; Elizabeth Halvorsen; Steven Chin; Michael Hutton; Henry Houlden; John Hardy; Timothy Lynch
Presenilin 1 mutation in an african american family presenting with atypical Alzheimer dementia.
Archives of neurology 2003;60(6):884-8.
2003: Demetrius M Maraganore; Mariza de Andrade; Timothy G Lesnick; Matthew J Farrer; James H Bower; John Hardy; Walter A Rocca
Complex interactions in Parkinson's disease: a two-phased approach.
Movement disorders : official journal of the Movement Disorder Society 2003;18(6):631-6.
2003: Melisa J Baptista; Casey O'Farrell; John Hardy; Mark Cookson
Microarray analysis reveals induction of heat shock proteins mRNAs by the torsion dystonia protein, TorsinA.
Neuroscience letters 2003;343(1):5-8.
2003: Sarah J Lincoln; Joseph Wiley; Timothy Lynch; J William Langston; R Chen; Anthony E Lang; Ekaterina Rogaeva; Daniel S Sa; Renato P Munhoz; J Harris; Karen Marder; Christine Klein; Gina Bisceglio; Jennifer Hussey; A West; Mary Hulihan; John Hardy; Matthew J Farrer
Parkin-proven disease: common founders but divergent phenotypes.
Neurology 2003;60(10):1605-10.
2003: John Hardy; Andrew Singleton; Katrina Gwinn-Hardy
Ethnic differences and disease phenotypes.
Science (New York, N.Y.) 2003;300(5620):739-40.
2003: Melisa J Baptista; Casey O'Farrell; Sneha Daya; Rili Ahmad; David W Miller; John Hardy; Matthew J Farrer; Mark Cookson
Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines.
Journal of neurochemistry 2003;85(4):957-68.
2003: John Hardy; Mark Cookson; Andrew Singleton
Genes and parkinsonism.
Lancet neurology 2003;2(4):221-8.
2003: John Hardy
The relationship between amyloid and tau.
Journal of molecular neuroscience : MN 2003;20(2):203-6.
2003: Haydeh Payami; John G Nutt; Steven Gancher; Thomas D Bird; Melissa Gonzales McNeal; William K Seltzer; Jennifer Hussey; Paul Lockhart; Katrina Gwinn-Hardy; Amanda Adam Singleton; Andrew Singleton; John Hardy; Matthew J Farrer
SCA2 may present as levodopa-responsive parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2003;18(4):425-9.
2003: Fiona Pickford; Luisa Onstead; Carolina Camacho-Prihar; John Hardy; Eileen McGowan
Expression of mBRI2 in mice.
Neuroscience letters 2003;338(2):95-8.
2002: Leonard Petrucelli; Casey O'Farrell; Paul J Lockhart; Melisa J Baptista; Kathryn Kehoe; Liselot Vink; Peter Choi; Benjamin Wolozin; Matthew J Farrer; John Hardy; Mark Cookson
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.
Neuron 2002;36(6):1007-19.
2002: Ruth H Walker; Joseph H Friedman; Jill Wiener; Ronald Hobler; Katrina Gwinn-Hardy; Amanda Adam; Jennifer DeWolfe; Rebecca Gibbs; Matt Baker; Matthew J Farrer; Michael Hutton; John Hardy
A family with a tau P301L mutation presenting with parkinsonism.
Parkinsonism & related disorders 2002;9(2):121-3.
2002: John Hardy
Testing times for the "amyloid cascade hypothesis".
Neurobiology of aging 2002;23(6):1073-4.
2002: John Goudreau; Demetrius M Maraganore; Matthew J Farrer; Timothy G Lesnick; Andrew Singleton; James H Bower; John Hardy; Walter A Rocca
Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2002;17(6):1305-11.
2002: Virgilio Gerald H Evidente; Joel Advincula; Raymund Esteban; Paul Pasco; Jhoe Anthony Alfon; Filipinas F Natividad; Joven Cuanang; Amado San Luis; Katrina Gwinn-Hardy; John Hardy; Dena Hernandez; Andrew Singleton
Phenomenology of "Lubag" or X-linked dystonia-parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 2002;17(6):1271-7.
2002: Andrew B West; Demetrius M Maraganore; Julia Crook; Timothy G Lesnick; Paul J Lockhart; Kristen Wilkes; Gregory Kapatos; John Hardy; Matthew J Farrer
Functional association of the parkin gene promoter with idiopathic Parkinson's disease.
Human molecular genetics 2002;11(22):2787-92.
2002: John Hardy; Katrina Gwinn-Hardy; Patrick L McGeer; Huw Morris; Jordi Perez-Tur; John Steele
Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000.
Neurology 2002;59(7):1121; author reply 1121.
2002: Danielle Compton; Fabienne Wavrant DeVriéze; Ronald C. Petersen; Eric G Tangalos; Ling Li; John Hardy
Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers.
Neuroscience letters 2002;331(1):60-2.
2002: John Hardy
Pathways to primary neurodegenerative disease.
Neurología (Barcelona, Spain) 2002;17(8):399-401.
2002: Antonis Goulas; Liana Fidani; Alexandros Kotsis; Vassiliki Mirtsou; Ronald C. Petersen; Eric G Tangalos; John Hardy
An association study of a functional catalase gene polymorphism, -262C-->T, and patients with Alzheimer's disease.
Neuroscience letters 2002;330(2):210-3.
2002: Rohan de Silva; John Hardy; Julia Crook; Naheed Khan; Elizabeth A Graham; Christopher M Morris; Nicholas W Wood; Andrew J Lees
The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease.
Neuroscience letters 2002;330(2):201-3.
2002: Sub H Subramony; Dena Hernandez; Amanda Adam; Stephanie Smith-Jefferson; Jennifer Hussey; Katrina Gwinn-Hardy; Timothy Lynch; Olga McDaniel; John Hardy; Matthew J Farrer; Andrew Singleton
Ethnic differences in the expression of neurodegenerative disease: Machado-Joseph disease in Africans and Caucasians.
Movement disorders : official journal of the Movement Disorder Society 2002;17(5):1068-71.
2002: Huw R Morris; M Baker; K Yasojima; Henry Houlden; M Nadeem Khan; Nicholas W Wood; John Hardy; Murray Grossman; John Q Trojanowski; Tamas Revesz; Eileen H Bigio; C Bergeron; John C Janssen; Patrick L McGeer; Martin N Rossor; Andrew J Lees; Peter L Lantos; Michael Hutton
Analysis of tau haplotypes in Pick's disease.
Neurology 2002;59(3):443-5.
2002: John Hardy; Dennis J Selkoe
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
Science (New York, N.Y.) 2002;297(5580):353-6.
2002: jean-charles lambert; L Araria-Goumidi; L Myllykangas; C Ellis; J C Wang; M J Bullido; J M Harris; M J Artiga; D Hernandez; J M Kwon; B Frigard; Ronald C. Petersen; A M Cumming; Florence Pasquier; I Sastre; P J Tienari; A Frank; R Sulkava; John C Morris; D St Clair; D M A Mann; F Wavrant-DeVrièze; M Ezquerra-Trabalon; P Amouyel; John Hardy; M Haltia; F Valdivieso; Alison Goate; J Pérez-Tur; C L Lendon; M-C Chartier-Harlin
Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.
Neurology 2002;59(1):59-66.
2002: Simon Lovestone; John Hardy
Psychotic genes or forgetful ones?
Neurology 2002;59(1):11-2.
2002: Andrew West; Magali Periquet; Sarah J Lincoln; Christoph B Lücking; David Nicholl; Vincenzo Bonifati; Nina Rawal; Thomas Gasser; Ebba Lohmann; Jean-François Deleuze; Demetrius M Maraganore; Allan Levey; Nicholas W Wood; Alexandra Dürr; John Hardy; Alexis Brice; Matthew J Farrer
Complex relationship between Parkin mutations and Parkinson disease.
American journal of medical genetics 2002;114(5):584-91.
2002: Ruey-Meei Wu; Din-E Shan; Chen-Ming Sun; Ren-Shyan Liu; Wuh-Liang Hwu; Chun-Hwei Tai; Jennifer Hussey; Andrew West; Katrina Gwinn-Hardy; John Hardy; Judy Chen; Matthew J Farrer; Sarah J Lincoln
Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations.
Movement disorders : official journal of the Movement Disorder Society 2002;17(4):670-5.
2002: J. Paul Taylor; John Hardy; Kenneth H Fischbeck
Toxic proteins in neurodegenerative disease.
Science (New York, N.Y.) 2002;296(5575):1991-5.
2002: Parvin Pasalar; Hossein Najmabadi; Ali Reza Noorian; Babak Moghimi; Ali Jannati; Akbar Soltanzadeh; T Krefft; R Crook; John Hardy
An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).
Neurology 2002;58(10):1574-5.
2002: J Neil Henderson; Richard Crook; Julia Crook; John Hardy; Luisa Onstead; Linda Carson-Henderson; Pat Mayer; Bea Parker; Ronald C. Petersen; Birdie Williams
Apolipoprotein E4 and tau allele frequencies among Choctaw Indians.
Neuroscience letters 2002;324(1):77-9.
2002: Demetrius M Maraganore; Matthew J Farrer; Shannon K McDonnell; Alexis Elbaz; Daniel J Schaid; John Hardy; Walter A Rocca
Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2002;17(3):509-12.
2002: John Hardy
[The history of Cushing's disease].
Neuro-Chirurgie 2002;48(2-3 Pt 2):144-8.
2002: John Hardy
[Harvey Cushing (1869-1939)].
Neuro-Chirurgie 2002;48(2-3 Pt 2):142-3.
2002: Liana Fidani; Antonis Goulas; Vassiliki Mirtsou; Ronald C. Petersen; Eric G Tangalos; Richard Crook; John Hardy
Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease.
Neuroscience letters 2002;323(1):81-3.
2002: Liana Fidani; Danielle Compton; John Hardy; Ronald C. Petersen; Eric G Tangalos; Vassiliki Mirtsou; Antonis Goulas; Fabienne Wavrant De Vrieze
No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease.
Neuroscience letters 2002;322(3):192-4.
2002: Liisa Myllykangas; Tuomo Polvikoski; Karoliina Reunanen; Fabienne Wavrant De-Vrieze; Clare Ellis; Dena Hernandez; Raimo Sulkava; Kimmo Kontula; Auli Verkkoniemi; Irma-Leena Notkola; John Hardy; Jordi Perez-Tur; Matti Haltia; Pentti J Tienari
ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain.
American journal of medical genetics 2002;114(3):288-91.
2002: Matthew J Farrer; Lisa Skipper; Marianne Berg; Gina Bisceglio; Melissa Hanson; John Hardy; Amanda Adam; Katrina Gwinn-Hardy; Jan Aasly
The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population.
Neuroscience letters 2002;322(2):83-6.
2002: Stuart Pickering-Brown; A M T Richardson; Julie S Snowden; AM McDonagh; Alistair Burns; W Braude; Matt Baker; W-K Liu; S-H Yen; John Hardy; Michael Hutton; Y Davies; David Allsop; David Craufurd; David Neary; D M A Mann
Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene.
Brain : a journal of neurology 2002;125(Pt 4):732-51.
2002: John Hardy
The real problem in association studies.
American journal of medical genetics 2002;114(2):253.
2002: Amanda Myers; Fabienne Wavrant De-Vrieze; Peter Holmans; Marian Hamshere; Richard Crook; Danielle Compton; Helen Marshall; David Meyer; Shantia Shears; Jeremy Booth; Dzanan Ramic; Heather Knowles; John C Morris; Nigel Williams; Nadine Norton; Richard Abraham; Pat Kehoe; Hywel Williams; Varuni Rudrasingham; Frances Rice; Peter Giles; Nigel Tunstall; Lesley Jones; Simon Lovestone; Julie Williams; Michael J Owen; John Hardy; Alison Goate
Full genome screen for Alzheimer disease: stage II analysis.
American journal of medical genetics 2002;114(2):235-44.
2002: Zareen Amtul; Patrick A Lewis; Sian Piper; Richard Crook; Matt Baker; Kirk Findlay; Andrew Singleton; Marion Hogg; Linda Younkin; Steven G Younkin; John Hardy; Michael Hutton; Bradley Boeve; David F Tang-Wai; todd golde
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease 2002;9(2):269-73.
2002: Paul J Lockhart; Benjamin Holtom; Sarah J Lincoln; Jennifer Hussey; Alexander Zimprich; Thomas Gasser; Zbigniew K Wszolek; John Hardy; Matthew J Farrer
The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3.
Gene 2002;285(1-2):229-37.
2002: Matthew J Farrer; John Hardy; Michael Hutton; Demetrius M Maraganore; Yoshio Tsuboi; Zbigniew K Wszolek
Identifying genetic factors in Parkinson disease.
JAMA : the journal of the American Medical Association 2002;287(6):715-6.
2002: David F Tang-Wai; P Lewis; Bradley Boeve; Michael Hutton; todd golde; Matthew Baker; John Hardy; V Michels; Robert J Ivnik; C Jack; Ronald C. Petersen
Familial frontotemporal dementia associated with a novel presenilin-1 mutation.
Dementia and geriatric cognitive disorders 2002;14(1):13-21.
2002: Richard Caselli; Joseph Hentz; David Osborne; Neill R Graff-Radford; Carolyn J Barbieri; Gene Alexander; Geri Hall; Eric Reiman; John Hardy; Ann M Saunders
Apolipoprotein E and intellectual achievement.
Journal of the American Geriatrics Society 2002;50(1):49-54.
2002: James F Meschia; Robert D Brown; Thomas G Brott; Felix E Chukwudelunzu; John Hardy; Stephen S Rich
The Siblings With Ischemic Stroke Study (SWISS) protocol.
BMC medical genetics 2002;3():1.
2002: Bradley Boeve; Demetrius M Maraganore; Joseph E Parisi; Robert J Ivnik; Barbara F Westmoreland; dennis dickson; Michael Hutton; John Hardy; Richard Caselli; Ronald C. Petersen
Corticobasal degeneration and frontotemporal dementia presentations in a kindred with nonspecific histopathology.
Dementia and geriatric cognitive disorders 2002;13(2):80-90.
2002: Virgilio Gerald H Evidente; Katrina Gwinn-Hardy; John Hardy; Dena Hernandez; Andrew Singleton
X-linked dystonia ("Lubag") presenting predominantly with parkinsonism: a more benign phenotype?
Movement disorders : official journal of the Movement Disorder Society 2002;17(1):200-2.
2001: Casey O'Farrell; D D Murphy; Leonard Petrucelli; Andrew Singleton; Jennifer Hussey; Matthew J Farrer; John Hardy; dennis dickson; Mark Cookson
Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells.
Brain research. Molecular brain research 2001;97(1):94-102.
2001: Richard Abraham; Amanda Myers; Fabienne Wavrant DeVrieze; Marian Hamshere; Hollie V Thomas; Helen Marshall; Danielle Compton; Gillian Spurlock; Darko Turic; Bastiaan Hoogendoorn; Jennifer M Kwon; Ronald C. Petersen; Eric G Tangalos; J Norton; John C Morris; Ross Bullock; D Liolitsa; Simon Lovestone; John Hardy; Alison Goate; Michael O'Donovan; Julie Williams; Michael J Owen; Lesley Jones
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.
Human genetics 2001;109(6):646-52.
2001: John Hardy; Matthias Edinger; Michael H Bachmann; Robert S Negrin; C Garrison Fathman; Christopher H Contag
Bioluminescence imaging of lymphocyte trafficking in vivo.
Experimental hematology 2001;29(12):1353-60.
2001: James F Meschia; Robert D Brown; Thomas G Brott; John Hardy; Elizabeth J Atkinson; Peter C O'Brien
Feasibility of an affected sibling pair study in ischemic stroke: results of a 2-center family history registry.
Stroke; a journal of cerebral circulation 2001;32(12):2939-41.
2001: Henry Houlden; Richard Crook; R J Dolan; J McLaughlin; Tamas Revesz; John Hardy
A novel presenilin mutation (M233V) causing very early onset Alzheimer's disease with Lewy bodies.
Neuroscience letters 2001;313(1-2):93-5.
2001: Donna Wilcock; Marcia N Gordon; Kenneth Ugen; Paul Gottschall; Giovanni DiCarlo; Chad A Dickey; Kristal W Boyett; Paul T Jantzen; Karen E Connor; J Melachrino; John Hardy; Dave Morgan
Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels.
DNA and cell biology 2001;20(11):731-6.
2001: Huw R Morris; M Nadeem Khan; John C Janssen; J M Brown; J Perez-Tur; M Baker; M Ozansoy; John Hardy; Michael Hutton; Nicholas W Wood; Andrew J Lees; Tamas Revesz; Peter Lantos; Martin N Rossor
The genetic and pathological classification of familial frontotemporal dementia.
Archives of neurology 2001;58(11):1813-6.
2001: Demetrius M Maraganore; Dena G Hernandez; Andrew Singleton; Matthew J Farrer; Shannon K McDonnell; Michael Hutton; John Hardy; Walter A Rocca
Case-Control study of the extended tau gene haplotype in Parkinson's disease.
Annals of neurology 2001;50(5):658-61.
2001: T V Le; Richard Crook; John Hardy; dennis dickson
Cotton wool plaques in non-familial late-onset Alzheimer disease.
Journal of neuropathology and experimental neurology 2001;60(11):1051-61.
2001: Huw R Morris; S Al-Sarraj; Claudia Schwab; Katrina Gwinn-Hardy; Jordi Perez-Tur; Nicholas W Wood; John Hardy; Andrew J Lees; Patrick L McGeer; Susan E Daniel; John C Steele
A clinical and pathological study of motor neurone disease on Guam.
Brain : a journal of neurology 2001;124(Pt 11):2215-22.
2001: Liisa Myllykangas; Tuomo Polvikoski; Raimo Sulkava; Irma-Leena Notkola; Sari Rastas; Auli Verkkoniemi; Pentti J Tienari; Leena Niinistö; John Hardy; Jordi Pérez-Tur; Kimmo Kontula; Matti Haltia
Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study.
Annals of medicine 2001;33(7):486-92.
2001: WK Liu; T V Le; Jennifer Adamson; Matt Baker; Natalie Cookson; John Hardy; Michael Hutton; Shu-Hui C. Yen; dennis dickson
Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy.
Annals of neurology 2001;50(4):494-502.
2001: Peter Choi; Natalie Golts; Heather Snyder; M Chong; Leonard Petrucelli; John Hardy; Dennis Sparkman; E Cochran; John Lee; Benjamin Wolozin
Co-association of parkin and alpha-synuclein.
Neuroreport 2001;12(13):2839-43.
2001: Andrew B West; Alexander Zimprich; Paul J Lockhart; Matthew J Farrer; Andrew Singleton; B Holtom; Sarah J Lincoln; A Hofer; L Hill; Bertram Müller-Myhsok; Zbigniew K Wszolek; John Hardy; Thomas Gasser
Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
European journal of human genetics : EJHG 2001;9(9):659-66.
2001: Wayne C McCormick; John Hardy; Walter A Kukull; James D Bowen; Linda Teri; S Zitzer; Eric B Larson
Healthcare utilization and costs in managed care patients with Alzheimer's disease during the last few years of life.
Journal of the American Geriatrics Society 2001;49(9):1156-60.
2001: Matthew J Farrer; Piu Chan; R Chen; Louis Tan ; Sarah J Lincoln; D Hernandez; Lysia Forno; Katrina Gwinn-Hardy; Leonard Petrucelli; Jennifer Hussey; Andrew Singleton; Caroline M Tanner; John Hardy; J William Langston
Lewy bodies and parkinsonism in families with parkin mutations.
Annals of neurology 2001;50(3):293-300.
2001: Andrew West; Matthew J Farrer; Leonard Petrucelli; Mark Cookson; Paul Lockhart; John Hardy
Identification and characterization of the human parkin gene promoter.
Journal of neurochemistry 2001;78(5):1146-52.
2001: Jada Lewis; dennis dickson; Wen-Lang Lin; L Chisholm; A Corral; G Jones; Shu-Hui C. Yen; Naruhiko Sahara; Lisa Skipper; Debra Yager; Christopher B Eckman; John Hardy; Michael Hutton; Eileen McGowan
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Science (New York, N.Y.) 2001;293(5534):1487-91.
2001: Richard Caselli; David Osborne; Eric Reiman; Joseph Hentz; C J Barbieri; Ann M Saunders; John Hardy; Neill R Graff-Radford; Geri Hall; Gene Alexander
Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study.
Journal of the neurological sciences 2001;189(1-2):93-8.
2001: Matthew J Farrer; Demetrius M Maraganore; Paul Lockhart; Andrew Singleton; Timothy G Lesnick; Mariza de Andrade; Andrew West; R de Silva; John Hardy; D Hernandez
alpha-Synuclein gene haplotypes are associated with Parkinson's disease.
Human molecular genetics 2001;10(17):1847-51.
2001: Patrick A Lewis; S Piper; Matt Baker; Luisa Onstead; Michael Murphy; John Hardy; Rong Wang; Eileen McGowan; todd golde
Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides.
Biochimica et biophysica acta 2001;1537(1):58-62.
2001: John Hardy; Richard Crook
Presenilin mutations line up along transmembrane alpha-helices.
Neuroscience letters 2001;306(3):203-5.
2001: Henry Houlden; M Baker; H R Morris; N MacDonald; S Pickering-Brown; Jennifer Adamson; Andrew J Lees; Martin N Rossor; Niall Quinn; A Kertesz; M N Khan; John Hardy; P L Lantos; P St George-Hyslop; David G Munoz; D M A Mann; Anthony E Lang; C Bergeron; Eileen H Bigio; Irene Litvan; K P Bhatia; dennis dickson; Nicholas W Wood; Michael Hutton
Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype.
Neurology 2001;56(12):1702-6.
2001: Tuomo Polvikoski; Raimo Sulkava; Liisa Myllykangas; Irma-Leena Notkola; Leena Niinistö; Auli Verkkoniemi; K Kainulainen; Kimmo Kontula; Jordi Pérez-Tur; John Hardy; Matti Haltia
Prevalence of Alzheimer's disease in very elderly people: a prospective neuropathological study.
Neurology 2001;56(12):1690-6.
2001: Yasuji Matsuoka; Miquel Vila; Sarah J Lincoln; Alison L McCormack; M Picciano; John LaFrancois; X Yu; dennis dickson; William J Langston; E McGowan; Matthew J Farrer; John Hardy; karen duff; Serge Przedborski; Donato A Di Monte
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.
Neurobiology of disease 2001;8(3):535-9.
2001: Auli Verkkoniemi; Hannu Kalimo; Anders Paetau; Mirja Somer; Takeshi Iwatsubo; John Hardy; Matti Haltia
Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype.
Journal of neuropathology and experimental neurology 2001;60(5):483-92.
2001: dennis dickson; Matthew J Farrer; Sarah J Lincoln; R P Mason; T R Zimmerman; Lawrence I Golbe; John Hardy
Pathology of PD in monozygotic twins with a 20-year discordance interval.
Neurology 2001;56(7):981-2.
2001: Matthew J Farrer; Alain Destée; Clotilde Levecque; Andrew Singleton; Simone Engelender; E Becquet; Vincent Mouroux; Florence Richard; Luc Defebvre; Richard Crook; D Hernandez; Christopher A Ross; John Hardy; Philippe Amouyel; Marie-Christine Chartier-Harlin
Genetic analysis of synphilin-1 in familial Parkinson's disease.
Neurobiology of disease 2001;8(2):317-23.
2001: Harald Steiner; Tamas Revesz; M Neumann; H Romig; MG Grim; B Pesold; Hans A Kretzschmar; John Hardy; Janice L Holton; Ralf Baumeister; Henry Houlden; Christian Haass
A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
The Journal of biological chemistry 2001;276(10):7233-9.
2001: Katrina Gwinn-Hardy; Andrew Singleton; P O'Suilleabhain; Michael Boss; David Nicholl; A Adam; J Hussey; P Critchley; John Hardy; Matthew J Farrer
Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family.
Archives of neurology 2001;58(2):296-9.
2001: John Hardy
Genetic dissection of primary neurodegenerative diseases.
Biochemical Society symposium 2001;(67):51-7.
2000: Amanda Myers; Peter Holmans; Helen Marshall; J Kwon; David Meyer; Dzanan Ramic; Shantia Shears; Jeremy Booth; FW DeVrieze; Richard Crook; Marian Hamshere; Richard Abraham; Nigel Tunstall; Frances Rice; S Carty; S Lillystone; Pat Kehoe; Varuni Rudrasingham; Lesley Jones; Simon Lovestone; Jordi Perez-Tur; Julie Williams; Michael J Owen; John Hardy; Alison Goate
Susceptibility locus for Alzheimer's disease on chromosome 10.
Science (New York, N.Y.) 2000;290(5500):2304-5.
2000: Dave Morgan; David M Diamond; Paul Gottschall; Kenneth Ugen; Chad A Dickey; John Hardy; karen duff; Paul T Jantzen; Giovanni DiCarlo; Donna Wilcock; K Connor; Jaime M Hatcher; CE Hope; Marcia N Gordon; Gary W Arendash
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
Nature 2000;408(6815):982-5.
2000: John Hardy
Nasal speculum.
Journal of neurosurgery 2000;93(6):1091-2.
2000: Stuart Pickering-Brown; Matt Baker; Shu-Hui C. Yen; W K Liu; M Hasegawa; Nigel J Cairns; P L Lantos; Martin N Rossor; Takeshi Iwatsubo; Y Davies; David Allsop; R Furlong; F Owen; John Hardy; D M A Mann; Michael Hutton
Pick's disease is associated with mutations in the tau gene.
Annals of neurology 2000;48(6):859-67.
2000: Li-Wen Ko; ND Mehta; Matthew J Farrer; Colin Easson; J Hussey; S Yen; John Hardy; Shu-Hui C. Yen
Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.
Journal of neurochemistry 2000;75(6):2546-54.
2000: Matthew J Farrer; T Destée; E Becquet; Fabienne Wavrant-De Vrièze; Vincent Mouroux; Florence Richard; Luc Defebvre; Sarah J Lincoln; John Hardy; Philippe Amouyel; Marie-Christine Chartier-Harlin
Linkage exclusion in French families with probable Parkinson' s disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(6):1075-83.
2000: Henry Houlden; M Baker; E McGowan; P Lewis; Michael Hutton; Richard Crook; Nicholas W Wood; Samir Kumar-Singh; J Geddes; M Swash; Francesco Scaravilli; Janice L Holton; Tammaryn Lashley; T Tomita; T Hashimoto; Auli Verkkoniemi; Hannu Kalimo; Mirja Somer; Anders Paetau; J J Martin; Christine Van Broeckhoven; todd golde; John Hardy; Matti Haltia; Tamas Revesz
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Annals of neurology 2000;48(5):806-8.
2000: Harald Steiner; Marcus Kostka; H Romig; G Basset; B Pesold; John Hardy; Anja Capell; Liane Meyn; M L Grim; Ralf Baumeister; K Fechteler; Christian Haass
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
Nature cell biology 2000;2(11):848-51.
2000: Patrick A Lewis; Jordi Perez-Tur; todd golde; John Hardy
The presenilin 1 C92S mutation increases abeta 42 production.
Biochemical and biophysical research communications 2000;277(1):261-3.
2000: Liisa Myllykangas; Tuomo Polvikoski; Raimo Sulkava; Auli Verkkoniemi; Pentti J Tienari; Leena Niinistö; Kimmo Kontula; John Hardy; Matti Haltia; Jordi Pérez-Tur
Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over.
Neuroscience letters 2000;292(3):195-8.
2000: Katrina Gwinn-Hardy; J Y Chen; H C Liu; T Y Liu; Michael Boss; William K Seltzer; A Adam; Andrew Singleton; Walter J Koroshetz; C Waters; John Hardy; Matthew J Farrer
Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese.
Neurology 2000;55(6):800-5.
2000: jean-charles lambert; L Goumidi; F W Vrièze; Bernard Frigard; J M Harris; A Cummings; J Coates; Florence Pasquier; Dominique Cottel; M Gaillac; David St Clair; D M A Mann; John Hardy; Corinne Lendon; Philippe Amouyel; Marie-Christine Chartier-Harlin
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease.
Human molecular genetics 2000;9(15):2275-80.
2000: N Ostrerova-Golts; Leonard Petrucelli; John Hardy; John Lee; M Farer; Benjamin Wolozin
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(16):6048-54.
2000: Jada Lewis; Eileen McGowan; J Rockwood; Heather L Melrose; Parimala Nacharaju; M van Slegtenhorst; Katrina Gwinn-Hardy; M Paul Murphy; Matt Baker; X Yu; karen duff; John Hardy; A Corral; Wen-Lang Lin; Shu-Hui C. Yen; dennis dickson; Peter Davies; Michael Hutton
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Nature genetics 2000;25(4):402-5.
2000: Demetrius M Maraganore; Matthew J Farrer; John Hardy; Shannon K McDonnell; Daniel J Schaid; Walter A Rocca
Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(4):714-9.
2000: Katrina Gwinn-Hardy; ND Mehta; Matthew J Farrer; Demetrius M Maraganore; MD Muenter; Shu-Hui C. Yen; John Hardy; dennis dickson
Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p.
Acta neuropathologica 2000;99(6):663-72.
2000: Matt Baker; D Graff-Radford; F Wavrant-DeVrièze; Neill R Graff-Radford; Ronald C. Petersen; Emre Kokmen; Bradley Boeve; Liisa Myllykangas; Tuomo Polvikoski; Raimo Sulkava; A Verkoniemmi; Pentti J Tienari; Matti Haltia; John Hardy; Michael Hutton; Jordi Perez-Tur
No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease.
Neuroscience letters 2000;285(2):147-9.
2000: John Hardy
Frameless stereotaxy for transsphenoidal surgery.
Neurosurgery 2000;46(5):1269-70.
2000: James F Meschia; Thomas G Brott; Felix E Chukwudelunzu; John Hardy; Robert D Brown; I Meissner; L J Hall; Elizabeth J Atkinson; Peter C O'Brien
Verifying the stroke-free phenotype by structured telephone interview.
Stroke; a journal of cerebral circulation 2000;31(5):1076-80.
2000: John Hardy; Andrew Singleton
The future of genetic analysis of neurological disorders.
Neurobiology of disease 2000;7(2):65-9.
2000: Auli Verkkoniemi; Mirja Somer; Juha O Rinne; Liisa Myllykangas; Richard Crook; John Hardy; Matti Viitanen; Hannu Kalimo; Matti Haltia
Variant Alzheimer's disease with spastic paraparesis: clinical characterization.
Neurology 2000;54(5):1103-9.
2000: Katrina Gwinn-Hardy; Richard Crook; Sarah J Lincoln; Charles H Adler; John Caviness; John Hardy; Matthew J Farrer
A kindred with Parkinson's disease not showing genetic linkage to established loci.
Neurology 2000;54(2):504-7.
2000: John Hardy
Pathways to primary neurodegenerative disease.
Annals of the New York Academy of Sciences 2000;924():29-34.
1999: John Hardy
Neuronavigation in pituitary surgery.
Surgical neurology 1999;52(6):648-9.
1999: Lorenzo M Refolo; Christopher B Eckman; CM Prada; Debra Yager; Kumar Sambamurti; N Mehta; John Hardy; Steven G Younkin
Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
Journal of neurochemistry 1999;73(6):2383-8.
1999: John Hardy; Katrina Gwinn-Hardy
Neurodegenerative disease: a different view of diagnosis.
Molecular medicine today 1999;5(12):514-7.
1999: Demetrius M Maraganore; Matthew J Farrer; John Hardy; Sarah J Lincoln; Shannon K McDonnell; Walter A Rocca
Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.
Neurology 1999;53(8):1858-60.
1999: dennis dickson; W Liu; John Hardy; Matthew J Farrer; N Mehta; Ryan Uitti; M Mark; T Zimmerman; Lawrence I Golbe; JI Sage; Anders A F Sima; Constance J D'Amato; Roger L Albin; Sid Gilman; Shu-Hui C. Yen
Widespread alterations of alpha-synuclein in multiple system atrophy.
The American journal of pathology 1999;155(4):1241-51.
1999: Guy Prihar; A Verkkoniem; Jordi Perez-Tur; Richard Crook; Sarah J Lincoln; Henry Houlden; Mirja Somer; Anders Paetau; Hannu Kalimo; Andrew Grover; Liisa Myllykangas; Michael Hutton; John Hardy; Matti Haltia
Alzheimer disease PS-1 exon 9 deletion defined.
Nature medicine 1999;5(10):1090.
1999: Harald Steiner; karen duff; Anja Capell; H Romig; MG Grim; Sarah J Lincoln; John Hardy; X Yu; M Picciano; K Fechteler; Martin Citron; R Kopan; B Pesold; S Keck; Miriam Baader; Taisuke Tomita; Takeshi Iwatsubo; Ralf Baumeister; Christian Haass
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: S Froelich; Henry Houlden; Patrizia Rizzu; Sumi Chakraverty; Matt Baker; J Kwon; P Nowotny; A Isaacs; V Nowotny; E Wauters; Marijke J van Baren; Ben A Oostra; John Hardy; Lars Lannfelt; Alison Goate; Michael Hutton; Corinne Lendon; Peter Heutink
Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21.
Genomics 1999;60(2):129-36.
1999: Liisa Myllykangas; Tuomo Polvikoski; Raimo Sulkava; Auli Verkkoniemi; Richard Crook; Pentti J Tienari; A K Pusa; Leena Niinistö; P O'Brien; Kimmo Kontula; John Hardy; Matti Haltia; Jordi Pérez-Tur
Genetic association of alpha2-macroglobulin with Alzheimer's disease in a Finnish elderly population.
Annals of neurology 1999;46(3):382-90.
1999: John Hardy
Pathways to primary neurodegenerative disease.
Mayo Clinic proceedings. Mayo Clinic 1999;74(8):835-7.
1999: Chris De Jonghe; Marc Cruts; Ekaterina Rogaeva; C Tysoe; Andrew Singleton; hugo vanderstichele; W Meschino; Bart Dermaut; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; Christopher M Morris; John Hardy; David C Rubinsztein; Peter St George-Hyslop; Christine Van Broeckhoven
Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.
Human molecular genetics 1999;8(8):1529-40.
1999: Biswadjiet S Harhangi; Matthew J Farrer; Sarah J Lincoln; Vincenzo Bonifati; Giuseppe Meco; Giuseppe De Michele; Alexis Brice; Alexandra Dürr; M Martinez; Thomas Gasser; Benjamin Bereznai; Jenny R Vaughan; Nicholas W Wood; John Hardy; Ben A Oostra; Monique Breteler
The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease.
Neuroscience letters 1999;270(1):1-4.
1999: Jordi Pérez-Tur; Luc BUEE; Huw R Morris; S C Waring; Luisa Onstead; Fabienne Wavrant-De Vrièze; Richard Crook; V Buée-Scherrer; Patrick R Hof; Ronald C. Petersen; Patrick L McGeer; André Delacourte; Michael Hutton; Teepu Siddique; J Eric Ahlskog; John Hardy; John C Steele
Neurodegenerative diseases of Guam: analysis of TAU.
Neurology 1999;53(2):411-3.
1999: N Ostrerova; Leonard Petrucelli; Matthew J Farrer; N Mehta; Peter Choi; John Hardy; Benjamin Wolozin
alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(14):5782-91.
1999: Sarah J Lincoln; Richard Crook; Marie-Christine Chartier-Harlin; Katrina Gwinn-Hardy; Matt Baker; Vincent Mouroux; Florence Richard; E Becquet; Philippe Amouyel; Alain Destée; John Hardy; Matthew J Farrer
No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.
Neuroscience letters 1999;269(2):107-9.
1999: Fabienne Wavrant-De Vrièze; Richard Crook; Peter Holmans; Pat Kehoe; Michael J Owen; Julie Williams; K Roehl; D K Laliiri; Shantia Shears; Jeremy Booth; W Wu; Alison Goate; Marie-Christine Chartier-Harlin; John Hardy; Jordi Pérez-Tur
Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease.
Neuroscience letters 1999;269(2):67-70.
1999: Katrina Gwinn-Hardy; V G Evidente; C Waters; MD Muenter; John Hardy
L-dopa slows the progression of familial parkinsonism.
Lancet 1999;353(9167):1850-1.
1999: Guy Prihar; Fanny Gonzalez-de-Chavez; Matt Baker; Richard Crook; Eileen McGowan; Andrew Grover; John Hardy; Michael Hutton
A novel candidate presenilin-1 interacting protein containing tetratricopeptide repeats.
Neuroreport 1999;10(7):1409-15.
1999: F Wavrant-DeVrièze; jean-charles lambert; L Stas; Richard Crook; Dominique Cottel; Florence Pasquier; Bernard Frigard; M Lambrechts; Els Thiry; Philippe Amouyel; J P Tur; Marie-Christine Chartier-Harlin; John Hardy; Fred Van Leuven
Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease.
Human genetics 1999;104(5):432-4.
1999: Varuni Rudrasingham; Fabienne Wavrant-De Vrièze; jean-charles lambert; S Chakraverty; Pat Kehoe; Richard Crook; Philippe Amouyel; W Wu; Frances Rice; Jordi Pérez-Tur; Bernard Frigard; John C Morris; S Carty; Ronald C. Petersen; Dominique Cottel; Nigel Tunstall; Peter Holmans; Simon Lovestone; Marie-Christine Chartier-Harlin; Alison Goate; John Hardy; Michael J Owen; Julie Williams
Alpha-2 macroglobulin gene and Alzheimer disease.
Nature genetics 1999;22(1):17-9; author reply 21-2.
1999: John Hardy; A Israël
Alzheimer's disease. In search of gamma-secretase.
Nature 1999;398(6727):466-7.
1999: Matt Baker; Irene Litvan; Henry Houlden; Jennifer Adamson; dennis dickson; Jordi Perez-Tur; John Hardy; Timothy Lynch; Eileen H Bigio; Michael Hutton
Association of an extended haplotype in the tau gene with progressive supranuclear palsy.
Human molecular genetics 1999;8(4):711-5.
1999: M Ilyas Kamboh; C E Aston; Jordi Perez-Tur; Emre Kokmen; Robert E Ferrell; John Hardy; Steven T DeKosky
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease.
Neuroscience letters 1999;263(2-3):129-32.
1999: F Wavrant-DeVrièze; Varuni Rudrasingham; jean-charles lambert; S Chakraverty; Pat Kehoe; Richard Crook; Philippe Amouyel; W Wu; Peter Holmans; Frances Rice; Jordi Pérez-Tur; Bernard Frigard; John C Morris; S Carty; Dominique Cottel; Nigel Tunstall; Simon Lovestone; Ronald C. Petersen; Marie-Christine Chartier-Harlin; Alison Goate; Michael J Owen; Julie Williams; John Hardy
No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
Neuroscience letters 1999;262(2):137-9.
1999: Sarah J Lincoln; J Vaughan; Nicholas W Wood; Matt Baker; J Adamson; Katrina Gwinn-Hardy; Timothy Lynch; John Hardy; Matthew J Farrer
Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease.
Neuroreport 1999;10(2):427-9.
1999: Henry Houlden; Patrizia Rizzu; M Stevens; P de Knijff; C.M. Duijn; John C van Swieten; Peter Heutink; Jordi Perez-Tur; V Thomas; Matt Baker; H Morris; Martin N Rossor; J C Jannsen; Ronald C. Petersen; P Dodd; F Dark; Bradley Boeve; dennis dickson; Peter Davies; Stuart Pickering-Brown; D M A Mann; Jennifer Adamson; Timothy Lynch; Haydeh Payami; John Hardy
Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations.
Neuroscience letters 1999;260(3):193-5.
1999: H R Morris; J Perez-Tur; John C Janssen; J Brown; Andrew J Lees; Nicholas W Wood; John Hardy; Michael Hutton; Martin N Rossor
Mutation in the tau exon 10 splice site region in familial frontotemporal dementia.
Annals of neurology 1999;45(2):270-1.
1999: Pat Kehoe; Fabienne Wavrant De-Vrieze; Richard Crook; W S Wu; Peter Holmans; Iain Fenton; Gillian Spurlock; Nadine Norton; Hywel Williams; Nigel Williams; Simon Lovestone; Jordi Perez-Tur; Michael Hutton; Marie-Christine Chartier-Harlin; Shantia Shears; K Roehl; Jeremy Booth; W Van Voorst; Dzanan Ramic; Julie Williams; Alison Goate; John Hardy; Michael J Owen
A full genome scan for late onset Alzheimer's disease.
Human molecular genetics 1999;8(2):237-45.
1999: Sarah J Lincoln; Katrina Gwinn-Hardy; John Goudreau; Marie-Christine Chartier-Harlin; Matt Baker; Vincent Mouroux; Florence Richard; Alain Destée; E Becquet; Philippe Amouyel; Timothy Lynch; John Hardy; Matthew J Farrer
No pathogenic mutations in the persyn gene in Parkinson's disease.
Neuroscience letters 1999;259(1):65-6.
1999: Matthew J Farrer; Katrina Gwinn-Hardy; Michael Hutton; John Hardy
The genetics of disorders with synuclein pathology and parkinsonism.
Human molecular genetics 1999;8(10):1901-5.
1999: John Hardy
The shorter amyloid cascade hypothesis.
Neurobiology of aging 1999;20(1):85; discussion 87.
1999: Matthew J Farrer; Katrina Gwinn-Hardy; MD Muenter; FW DeVrieze; Richard Crook; Jordi Perez-Tur; Sarah J Lincoln; Demetrius M Maraganore; Charles H Adler; S Newman; K MacElwee; P McCarthy; C Miller; C Waters; John Hardy
A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor.
Human molecular genetics 1999;8(1):81-5.
1998: John Hardy; Katrina Gwinn-Hardy
Genetic classification of primary neurodegenerative disease.
Science (New York, N.Y.) 1998;282(5391):1075-9.
1998: J Grünberg; Jochen Walter; Christopher B Eckman; Anja Capell; A Schindzielorz; Steven G Younkin; N Mehta; John Hardy; Christian Haass
Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40.
Neuroreport 1998;9(14):3293-9.
1998: John Hardy; karen duff; K G Hardy; Jordi Perez-Tur; Michael Hutton
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.
Nature neuroscience 1998;1(5):355-8.
1998: jean-charles lambert; C Berr; Florence Pasquier; André Delacourte; Bernard Frigard; Dominique Cottel; Jordi Pérez-Tur; Vincent Mouroux; M Mohr; D Cécyre; Douglas Galasko; Corinne Lendon; J Poirier; John Hardy; D M A Mann; Philippe Amouyel; Marie-Christine Chartier-Harlin
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.
Human molecular genetics 1998;7(9):1511-6.
1998: W S Wu; Peter Holmans; F Wavrant-DeVrièze; Shantia Shears; Pat Kehoe; Richard Crook; Jeremy Booth; Nigel Williams; Jordi Pérez-Tur; K Roehl; Iain Fenton; Marie-Christine Chartier-Harlin; Simon Lovestone; Julie Williams; Michael Hutton; John Hardy; Michael J Owen; Alison Goate
Genetic studies on chromosome 12 in late-onset Alzheimer disease.
JAMA : the journal of the American Medical Association 1998;280(7):619-22.
1998: Michael Hutton; C L Lendon; P Rizzu; M Baker; S Froelich; H Houlden; S Pickering-Brown; S Chakraverty; A Isaacs; Andrew Grover; J Hackett; J Adamson; Sarah J Lincoln; dennis dickson; Peter Davies; Ronald C. Petersen; M Stevens; E de Graaff; E Wauters; J van Baren; M Hillebrand; M Joosse; J M Kwon; P Nowotny; L K Che; J Norton; John C Morris; L A Reed; John Q Trojanowski; Hans Basun; Lars Lannfelt; M Neystat; Stanley Fahn; F Dark; T Tannenberg; P R Dodd; N Hayward; J B Kwok; P R Schofield; A Andreadis; J Snowden; D Craufurd; David Neary; F Owen; B A Oostra; John Hardy; Alison Goate; J van Swieten; D M A Mann; T Lynch; Peter Heutink
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.
Nature 1998;393(6686):702-5.
1998: Richard Crook; Auli Verkkoniemi; Jordi Perez-Tur; N Mehta; Matt Baker; Henry Houlden; Matthew J Farrer; Michael Hutton; Sarah J Lincoln; John Hardy; Katrina Gwinn-Hardy; Mirja Somer; Anders Paetau; Hannu Kalimo; Raija Ylikoski; M Pöyhönen; S Kucera; Matti Haltia
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.
Nature medicine 1998;4(4):452-5.
1998: Jenny R Vaughan; Matthew J Farrer; Zbigniew K Wszolek; Thomas Gasser; Alexandra Durr; Yves Agid; Vincenzo Bonifati; G DeMichele; Giampiero Volpe; Sarah J Lincoln; Monique Breteler; Giuseppe Meco; Alexis Brice; CD Marsden; John Hardy; Nicholas W Wood
Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. The European Consortium on Genetic Susceptibility in Parkinson's Disease (GSPD).
Human molecular genetics 1998;7(4):751-3.
1998: John Hardy; Jordi Pérez-Tur; Matt Baker; Matthew J Farrer; Richard Crook; Michael Hutton; William G Johnson; Katrina Gwinn-Hardy; MD Muenter; W A Rocca; Demetrius M Maraganore
Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with Lewy body parkinsonism.
American journal of medical genetics 1998;81(2):166-71.
1998: Matthew J Farrer; Fabienne Wavrant De-Vrieze; Richard Crook; L Boles; Jordi Perez-Tur; John Hardy; William G Johnson; J Steele; Demetrius M Maraganore; Katrina Gwinn-Hardy; Timothy Lynch
Low frequency of alpha-synuclein mutations in familial Parkinson's disease.
Annals of neurology 1998;43(3):394-7.
1998: Henry Houlden; Richard Crook; Hubert Backhovens; Guy Prihar; Matt Baker; Michael Hutton; Martin N Rossor; J J Martin; Christine Van Broeckhoven; John Hardy
ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.
American journal of medical genetics 1998;81(1):117-21.
1998: ND Mehta; Lorenzo M Refolo; Christopher B Eckman; S Sanders; Debra Yager; Jordi Perez-Tur; Steven G Younkin; karen duff; John Hardy; Michael Hutton
Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.
Annals of neurology 1998;43(2):256-8.
1998: John Hardy
The anatomy of tremor.
Journal of neurosurgery 1998;88(2):353-4.
1998: Michael Hutton; Jordi Pérez-Tur; John Hardy
Genetics of Alzheimer's disease.
Essays in biochemistry 1998;33():117-31.
1998: R J Harvey; D Ellison; John Hardy; Michael Hutton; P K Roques; John Collinge; Nick C Fox; Martin N Rossor
Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.
Journal of neurology, neurosurgery, and psychiatry 1998;64(1):44-9.
1998: Leigh A Holcomb; Marcia N Gordon; Eileen McGowan; X Yu; S Benkovic; Paul T Jantzen; K Wright; I Saad; R Mueller; Dave Morgan; S Sanders; Cynthia Zehr; K O'Campo; John Hardy; CM Prada; Christopher B Eckman; Steven G Younkin; Karen K. Hsiao Ashe; karen duff
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
Nature medicine 1998;4(1):97-100.
1998: Marc Cruts; C.M. Duijn; Hubert Backhovens; Marleen Van den Broeck; A Wehnert; Sally Serneels; R Sherrington; Michael Hutton; John Hardy; Peter St George-Hyslop; Albert Hofman; Christine Van Broeckhoven
Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.
Human molecular genetics 1998;7(1):43-51.
1997: T Lynch; Matthew J Farrer; Michael Hutton; John Hardy
Genetics of Parkinson's disease.
Science (New York, N.Y.) 1997;278(5341):1212-3.
1997: Matt Baker; John B J Kwok; S Kucera; Richard Crook; Matthew J Farrer; Henry Houlden; A Isaacs; Sarah J Lincoln; Luisa Onstead; John Hardy; L Wittenberg; P Dodd; S Webb; N Hayward; T Tannenberg; A Andreadis; Marianne Hallupp; P Schofield; F Dark; Michael Hutton
Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22.
Annals of neurology 1997;42(5):794-8.
1997: jean-charles lambert; Jordi Pérez-Tur; Marie-Joëlle Dupire; Douglas Galasko; D M A Mann; P Amouyel; John Hardy; André Delacourte; Marie-Christine Chartier-Harlin
Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.
Human molecular genetics 1997;6(12):2151-4.
1997: Christopher B Eckman; ND Mehta; Richard Crook; Jordi Perez-Tur; Guy Prihar; E Pfeiffer; Neill R Graff-Radford; P Hinder; Debra Yager; Brenda M Zenk; Lorenzo M Refolo; CM Prada; Steven G Younkin; Michael Hutton; John Hardy
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
Human molecular genetics 1997;6(12):2087-9.
1997: Bengt Winblad; John Hardy
European research on Alzheimer's disease.
Lancet 1997;350(9070):73-4.
1997: Richard Crook; R Ellis; M Shanks; Leon J Thal; Jordi Perez-Tur; M Baker; Michael Hutton; T Haltia; John Hardy; Douglas Galasko
Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation.
Annals of neurology 1997;42(1):124-8.
1997: F Wavrant-DeVrièze; Jordi Pérez-Tur; jean-charles lambert; Bernard Frigard; Florence Pasquier; André Delacourte; Philippe Amouyel; John Hardy; Marie-Christine Chartier-Harlin
Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.
Neuroscience letters 1997;227(1):68-70.
1997: John B J Kwok; Kevin Taddei; Marianne Hallupp; C Fisher; William S Brooks; G Anthony Broe; John Hardy; M J Fulham; G A Nicholson; R Stell; Peter St George-Hyslop; Paul E Fraser; Byron A Kakulas; Roger Clarnette; Norman Richard Relkin; Sam Gandy; Peter R Schofield; Ralph N Martins
Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.
Neuroreport 1997;8(6):1537-42.
1997: John Hardy
Amyloid, the presenilins and Alzheimer's disease.
Trends in neurosciences 1997;20(4):154-9.
1997: John Hardy
The Alzheimer family of diseases: many etiologies, one pathogenesis?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2095-7.
1997: Nick C Fox; A M Kennedy; R J Harvey; P L Lantos; P K Roques; J Collinge; John Hardy; Michael Hutton; John M Stevens; Elizabeth K Warrington; Martin N Rossor
Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor.
Brain : a journal of neurology 1997;120 ( Pt 3)():491-501.
1997: Michael Hutton; John Hardy
The presenilins and Alzheimer's disease.
Human molecular genetics 1997;6(10):1639-46.
1996: RV Ward; J B Davis; C W Gray; A J Barton; L G Bresciani; M Caivano; V F Murphy; karen duff; Michael Hutton; John Hardy; G W Roberts; EH Karran
Presenilin-1 is processed into two major cleavage products in neuronal cell lines.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(4):293-8.
1996: karen duff; Christopher B Eckman; Cynthia Zehr; X Yu; CM Prada; Jordi Perez-Tur; Michael Hutton; Luc BUEE; Yasuo Harigaya; Debra Yager; Dave Morgan; Marcia N Gordon; Leigh A Holcomb; Lorenzo M Refolo; B Zenk; John Hardy; Steven G Younkin
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Nature 1996;383(6602):710-3.
1996: A J Barton; B W Crook; EH Karran; F Brown; D Dewar; D M A Mann; R C Pearson; D I Graham; John Hardy; Michael Hutton; karen duff; Alison Goate; Robert Clark; G W Roberts
Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):213-8.
1996: Jordi Perez-Tur; Rhonda Croxton; K Wright; H Phillips; Cynthia Zehr; Richard Crook; Michael Hutton; John Hardy; EH Karran; G W Roberts; S Lancaster; T Haltia
A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):207-12.
1996: D M A Mann; Takeshi Iwatsubo; Nigel J Cairns; P L Lantos; David Nochlin; Shuzo M Sumi; Thomas D Bird; Parvoneh Poorkaj-Navas; John Hardy; Michael Hutton; Guy Prihar; Richard Crook; Martin N Rossor; Matti Haltia
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).
Annals of neurology 1996;40(2):149-56.
1996: Donalyn Scheuner; Christopher B Eckman; M Jensen; X Song; Martin Citron; N Suzuki; Thomas D Bird; John Hardy; Michael Hutton; Walter A Kukull; Eric B Larson; Ephrat Levy-Lahad; Matti Viitanen; Elaine Peskind; Parvoneh Poorkaj-Navas; Gerard D Schellenberg; Rudolph E Tanzi; Wilma Wasco; Lars Lannfelt; Dennis J Selkoe; Steven G Younkin
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Guy Prihar; R A Fuldner; Jordi Perez-Tur; Sarah J Lincoln; karen duff; Richard Crook; John Hardy; C A Philips; C Venter; C Talbot; Robert Clark; Alison Goate; J Li; H Potter; EH Karran; G W Roberts; Michael Hutton; M D Adams
Structure and alternative splicing of the presenilin-2 gene.
Neuroreport 1996;7(10):1680-4.
1996: Gopal Thinakaran; David R Borchelt; Michael K Lee; Hilda H Slunt; L Spitzer; G Kim; T Ratovitsky; F Davenport; C Nordstedt; M Seeger; John Hardy; Allan Levey; Sam Gandy; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Neuron 1996;17(1):181-90.
1996: John Hardy
New insights into the genetics of Alzheimer's disease.
Annals of medicine 1996;28(3):255-8.
1996: C Talbot; Henry Houlden; Nick Craddock; Richard Crook; Michael Hutton; Corinne Lendon; Guy Prihar; John C Morris; John Hardy; Alison Goate
Polymorphism in AACT gene may lower age of onset of Alzheimer's disease.
Neuroreport 1996;7(2):534-6.
1996: MC Royston; D M A Mann; Stuart Pickering-Brown; F Owen; Robert H Perry; R Ragbavan; C Khin-Nu; S Tyner; K Day; Richard Crook; John Hardy; GW Roberts
ApoE2 allele, Down's syndrome, and dementia.
Annals of the New York Academy of Sciences 1996;777():255-9.
1996: Robert Clark; Michael Hutton; C Talbot; M Wragg; Corinne Lendon; F Busfield; S W Han; Jordi Perez-Tur; M Adams; R Fuldner; G Roberts; EH Karran; John Hardy; Alison Goate
The role of presenilin 1 in the genetics of Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():551-8.
1996: John Hardy
Molecular genetics of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1996;165():13-7.
1995: John Hardy
Apolipoprotein E in the genetics and epidemiology of Alzheimer's disease.
American journal of medical genetics 1995;60(5):456-60.
1995: John Hardy; Michael Hutton
Two new genes for Alzheimer's disease.
Trends in neurosciences 1995;18(10):436.
1995: J Brown; A Ashworth; S Gydesen; A Sorensen; Martin N Rossor; John Hardy; John Collinge
Familial non-specific dementia maps to chromosome 3.
Human molecular genetics 1995;4(9):1625-8.
1995: A Ashworth; J Brown; S Gydesen; S A Sorensen; Martin N Rossor; John Hardy; John Collinge
Frontal lobe or 'nonspecific' dementias are genetically heterogeneous.
Neurology 1995;45(9):1781.
1995: Henry Houlden; Richard Crook; karen duff; Michael Hutton; John Collinge; P Roques; Martin N Rossor; John Hardy
Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
Neuroscience letters 1995;188(3):202-4.
1995: karen duff; John Hardy
Alzheimer's disease. Mouse model made.
Nature 1995;373(6514):476-7.
1995: Lars Lannfelt; Lena Lilius; Matti Viitanen; Henry Houlden; Martin N Rossor; John Hardy; Bengt Winblad; Hans Basun
Microsatellite D21S210 (GT-12) allele frequencies in sporadic Alzheimer's disease.
Acta neurologica Scandinavica 1995;91(2):145-8.
1995: Carol F Lippa; T W Smith; Ann M Saunders; R Crook; D Pulaski-Salo; Peter Davies; John Hardy; Allen D Roses; dennis dickson
Apolipoprotein E genotype and Lewy body disease.
Neurology 1995;45(1):97-103.
1994: John Hardy; Richard Crook; Guy Prihar; G Roberts; R Raghavan; Robert H Perry
Senile dementia of the Lewy body type has an apolipoprotein E epsilon 4 allele frequency intermediate between controls and Alzheimer's disease.
Neuroscience letters 1994;182(1):1-2.
1994: John Hardy
Alzheimer's disease. Molecular genetics.
The Journal of the Florida Medical Association 1994;81(11):759-61.
1994: John Hardy
Lewy bodies in Alzheimer's disease in which the primary lesion is a mutation in the amyloid precursor protein.
Neuroscience letters 1994;180(2):290-1.
1994: R Rempfer; Richard Crook; Henry Houlden; karen duff; Michael Hutton; G W Roberts; R Raghavan; Robert H Perry; John Hardy
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Lancet 1994;344(8925):815.
1994: Richard Crook; John Hardy; karen duff
Single-day apolipoprotein E genotyping.
Journal of neuroscience methods 1994;53(2):125-7.
1994: Henry Houlden; Richard Crook; John Hardy; P Roques; John Collinge; Martin N Rossor
Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus.
Neuroscience letters 1994;174(2):222-4.
1994: John Collinge; M S Palmer; K C Sidle; S P Mahal; T Campbell; J Brown; John Hardy; A E Brun; L Gustafson; E Bakker
Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease.
Journal of neurology, neurosurgery, and psychiatry 1994;57(6):762.
1994: John Hardy
Alzheimer's disease. Clinical molecular genetics.
Clinics in geriatric medicine 1994;10(2):239-47.
1994: John Hardy; Richard Crook; Robert H Perry; R Raghavan; G Roberts
ApoE genotype and Down's syndrome.
Lancet 1994;343(8903):979-80.
1994: Christine Van Broeckhoven; Hubert Backhovens; Marc Cruts; Jean-Jacques Martin; Richard Crook; Henry Houlden; John Hardy
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.
Neuroscience letters 1994;169(1-2):179-80.
1994: Lars Lannfelt; Nenad Bogdanovic; H Appelgren; Karin Axelman; Lena Lilius; G Hansson; Dale Schenk; John Hardy; Bengt Winblad
Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.
Neuroscience letters 1994;168(1-2):254-6.
1994: John Hardy
ApoE, amyloid, and Alzheimer's disease.
Science (New York, N.Y.) 1994;263(5146):454-5.
1994: John Hardy
Alzheimer's disease: the present situation and our tasks.
Neurobiology of aging 1994;15 Suppl 2():S111-2.
1994: karen duff; A McGuigan; Clare Huxley; F Schulz; John Hardy
Insertion of a pathogenic mutation into a yeast artificial chromosome containing the human amyloid precursor protein gene.
Gene therapy 1994;1(1):70-5.
1993: Lars Lannfelt; R Folkesson; Abdul H Mohammed; Bengt Winblad; D Hellgren; karen duff; John Hardy
Alzheimer's disease: molecular genetics and transgenic animal models.
Behavioural brain research 1993;57(2):207-13.
1993: John Hardy; G W Roberts
Smoking and neurogenerative diseases.
Lancet 1993;342(8881):1238.
1993: K Rooke; C Talbot; L James; R Anand; John Hardy; Alison Goate
A physical map of the human APP gene in YACs.
Mammalian genome : official journal of the International Mammalian Genome Society 1993;4(11):662-9.
1993: John Hardy; karen duff
Heterogeneity in Alzheimer's disease.
Annals of medicine 1993;25(5):437-40.
1993: A King; H Houlden; John Hardy; R Lane; A Chancellor; Jackie de Belleroche
Absence of linkage between chromosome 21 loci and familial amyotrophic lateral sclerosis.
Journal of medical genetics 1993;30(4):318.
1993: A M Kennedy; S Newman; Andrew McCaddon; J Ball; P Roques; Michael Mullan; John Hardy; Marie-Christine Chartier-Harlin; Richard S J Frackowiak; Elizabeth K Warrington
Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).
Brain : a journal of neurology 1993;116 ( Pt 2)():309-24.
1993: John Hardy
"Prion dementia".
Lancet 1993;341(8845):626-7; author reply 627-8.
1993: Rosa Adroer; C Lopez-Acedo; Rafael Oliva; John Hardy; L Fidani
A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and control cases.
Neuroscience letters 1993;150(1):33-4.
1993: M C Harlin; F Crawford; Daniel P Perl; J Steele; John Hardy
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene reveals the beta-amyloid sequence to be normal in cases of the parkinson dementia complex of Guam.
Journal of neural transmission. Parkinson's disease and dementia section 1993;5(1):63-5.
1992: Michael Mullan; Henry Houlden; M Windelspecht; L Fidani; C Lombardi; P Diaz; Martin N Rossor; Richard Crook; John Hardy; karen duff
A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.
Nature genetics 1992;2(4):340-2.
1992: John Hardy; Michael Mullan
Alzheimer's disease. In search of the soluble.
Nature 1992;359(6393):268-9.
1992: John Hardy
Framing beta-amyloid.
Nature genetics 1992;1(4):233-4.
1992: John Hardy
An 'anatomical cascade hypothesis' for Alzheimer's disease.
Trends in neurosciences 1992;15(6):200-1.
1992: John Collinge; J Brown; John Hardy; Michael Mullan; Martin N Rossor; H Baker; T J Crow; R Lofthouse; M Poulter; R Ridley
Inherited prion disease with 144 base pair gene insertion. 2. Clinical and pathological features.
Brain : a journal of neurology 1992;115 ( Pt 3)():687-710.
1992: L Fidani; K Rooke; Marie-Christine Chartier-Harlin; D Hughes; Rudolph E Tanzi; Michael Mullan; P Roques; Martin N Rossor; John Hardy; Alison Goate
Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile.
Human molecular genetics 1992;1(3):165-8.
1992: John Hardy; Gerry Higgins
Alzheimer's disease: the amyloid cascade hypothesis.
Science (New York, N.Y.) 1992;256(5054):184-5.
1992: Fiona Crawford; Marie-Christine Chartier-Harlin; Michael Mullan; John Hardy; André Delacourte; G Arnott
Alzheimer's--a correction.
Nature 1992;356(6368):390.
1992: D M A Mann; D Jones; Julie S Snowden; David Neary; John Hardy
Pathological changes in the brain of a patient with familial Alzheimer's disease having a missense mutation at codon 717 in the amyloid precursor protein gene.
Neuroscience letters 1992;137(2):225-8.
1992: John Hardy; Marie-Christine Chartier-Harlin; Michael Mullan
Alzheimer disease: the new agenda.
American journal of human genetics 1992;50(3):648-51.
1991: Fiona Crawford; John Hardy; Michael Mullan; Alison Goate; D Hughes; L Fidani; P Roques; Martin N Rossor; Marie-Christine Chartier-Harlin
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence.
Neuroscience letters 1991;133(1):1-2.
1991: Marie-Christine Chartier-Harlin; Fiona Crawford; Henry Houlden; AC Warren; D Hughes; L Fidani; Alison Goate; Martin N Rossor; P Roques; John Hardy
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
Nature 1991;353(6347):844-6.
1991: John Hardy; D Allsop
Amyloid deposition as the central event in the aetiology of Alzheimer's disease.
Trends in pharmacological sciences 1991;12(10):383-8.
1991: Michael J Owen; Alison Goate; John Hardy
A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80).
Nucleic acids research 1991;19(16):4574.
1991: R C Pearson; Michael Mullan; John Hardy; P J Harrison
Nicotine intake and Alzheimer's disease.
BMJ (Clinical research ed.) 1991;303(6798):361.
1991: Marie-Christine Chartier-Harlin; Fiona Crawford; K Hamandi; Michael Mullan; Alison Goate; John Hardy; Hubert Backhovens; J J Martin; Christine Van Broeckhoven
Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.
Neuroscience letters 1991;129(1):134-5.
1991: J Haan; John Hardy; Raymund A C Roos
Hereditary cerebral hemorrhage with amyloidosis--Dutch type: its importance for Alzheimer research.
Trends in neurosciences 1991;14(6):231-4.
1991: F Owen; M Poulter; John Collinge; Martin Leach; T Shah; R Lofthouse; Y F Chen; Timothy J Crow; A E Harding; John Hardy
Insertions in the prion protein gene in atypical dementias.
Experimental neurology 1991;112(2):240-2.
1991: C.M. Duijn; L Hendriks; Marc Cruts; John Hardy; Albert Hofman; Christine Van Broeckhoven
Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.
Lancet 1991;337(8747):978.
1991: C.M. Duijn; Christine Van Broeckhoven; John Hardy; Alison Goate; Martin N Rossor; A Vandenberghe; J J Martin; Albert Hofman; Michael Mullan
Evidence for allelic heterogeneity in familial early-onset Alzheimer's disease.
The British journal of psychiatry : the journal of mental science 1991;158():471-4.
1991: N G Irving; John Hardy; Steve D M Brown
The multipoint genetic mapping of mouse chromosome 16.
Genomics 1991;9(2):386-9.
1991: John Jefferys; P Mitchell; L O'Hara; C Tiley; John Hardy; S J Jordan; M Lynch; Jonathan D F Wadsworth
Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase.
Neurochemistry international 1991;18(3):373-9.
1991: J Brown; S Smith; A Brun; John Collinge; S Gydesen; John Hardy; Michael Mullan; Alison Goate
Genetic characterization of a novel familial dementia.
Annals of the New York Academy of Sciences 1991;640():181-3.
1991: Michael Mullan; L Giuffra; John Hardy; I Ovenstone; A R Haynes; L A James; R Williamson; P J Newton; Michael J Owen; P Roques
Clinical and pathologic features of chromosome 21-linked familial Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():177-80.
1990: Peter St George-Hyslop; Jonathan L Haines; Lindsay A Farrer; R Polinsky; Christine Van Broeckhoven; Alison Goate; D R McLachlan; H Orr; A C Bruni; Sandro Sorbi; I Rainero; J F Foncin; D Pollen; J M Cantu; R Tupler; N Voskresenskaya; Richard Mayeux; J Growden; V A Fried; Richard H Myers; L Nee; H Backhovens; J J Martin; Martin N Rossor; Michael J Owen; Michael Mullan; M E Percy; H Karlinsky; S Rich; L Heston; M Montesi; M Mortilla; N Nacmias; James Gusella; John Hardy
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
Nature 1990;347(6289):194-7.
1990: A J Barton; Paul J Harrison; A Najlerahim; J Heffernan; B McDonald; J R Robinson; D C Davies; W J Harrison; P Mitra; John Hardy
Increased tau messenger RNA in Alzheimer's disease hippocampus.
The American journal of pathology 1990;137(3):497-502.
1990: John Collinge; F Owen; M Poulter; Martin Leach; Timothy J Crow; Martin N Rossor; John Hardy; Michael Mullan; I Janota; P L Lantos
Prion dementia without characteristic pathology.
Lancet 1990;336(8706):7-9.
1990: Richard Frank Cowburn; John Hardy; Peter J Roberts
Glutamatergic neurotransmission in Alzheimer's disease.
Biochemical Society transactions 1990;18(3):390-2.
1990: Christine Van Broeckhoven; J Haan; Egbert Bakker; John Hardy; Wim Van Hul; A Wehnert; M Vegter-Van der Vlis; Raymund A C Roos
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).
Science (New York, N.Y.) 1990;248(4959):1120-2.
1990: A P Walker; Francis S Collins; Teepu Siddique; LH Yamaoka; Michael H Herbstreith; Margaret Pericak-Vance; S L Secore; Wu-Yen Hung; Alison Goate; John Hardy
D21S194, a jump clone from D21S16.
Nucleic acids research 1990;18(7):1931.
1990: P Wester; U Bergström; Anders Eriksson; C Gezelius; John Hardy; Bengt Winblad
Ventricular cerebrospinal fluid monoamine transmitter and metabolite concentrations reflect human brain neurochemistry in autopsy cases.
Journal of neurochemistry 1990;54(4):1148-56.
1990: Michael J Owen; L A James; John Hardy; R Williamson; Alison Goate
Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.
American journal of human genetics 1990;46(2):316-22.
1990: Alison Goate; John Hardy; Michael J Owen; A Haynes; L James; M Farrall; Michael Mullan; P Roques; Martin N Rossor
Genetics of Alzheimer's disease.
Advances in neurology 1990;51():197-8.
1990: John Hardy
Molecular genetics of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1990;129():29-31.
1989: Henry F Bradford; P Foley; M Docherty; H Fillit; V N Luine; B McEwen; G Bucht; B Winbald; John Hardy
Antibodies in serum of patients with Alzheimer's disease cause immunolysis of cholinergic nerve terminals from the rat cerebral cortex.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1989;16(4 Suppl):528-34.
1989: John Hardy; Alison Goate; Michael J Owen; Martin N Rossor
Presenile dementia associated with mosaic trisomy 21 in a patient with a Down syndrome child.
Lancet 1989;2(8665):743.
1989: John Hardy; Alison Goate; Michael J Owen; Michael Mullan; Martin N Rossor; R C Pearson
Modelling the occurrence and pathology of Alzheimer's disease.
Neurobiology of aging 1989;10(5):429-31; discussion 446-8.
1989: P R Dodd; W E Watson; M M Morrison; Graham A R Johnston; E D Bird; Richard Frank Cowburn; John Hardy
Uptake of gamma-aminobutyric acid and L-glutamic acid by synaptosomes from postmortem human cerebral cortex: multiple sites, sodium dependence and effect of tissue preparation.
Brain research 1989;490(2):320-31.
1989: John Hardy; N Irving; A Kessling
Down on chromosome 21?
Trends in neurosciences 1989;12(6):209-10.
1989: J Willoughby; Richard Frank Cowburn; John Hardy; Vivette Glover; Merton Sandler
1-Methyl-4-phenylpyridinium uptake by human and rat striatal synaptosomes.
Journal of neurochemistry 1989;52(2):627-31.
1989: John Hardy; Michael J Owen; Alison Goate; L A James; A R Haynes; Martin N Rossor; P Roques; Michael Mullan
Molecular genetics of Alzheimer's disease.
Biochemical Society transactions 1989;17(1):75-6.
1989: N G Irving; John Hardy; N Bahary; J M Friedman; Steve D M Brown
The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6.
Cytogenetics and cell genetics 1989;50(2-3):121-2.
1989: agneta nordberg; L Nilsson-Håkansson; Abdu Adem; John Hardy; Irina Alafuzoff; Z Lai; M Herrera-Marschitz; Bengt Winblad
The role of nicotinic receptors in the pathophysiology of Alzheimer's disease.
Progress in brain research 1989;79():353-62.
1989: Richard Frank Cowburn; John Hardy; R S Briggs; Peter J Roberts
Characterisation, density, and distribution of kainate receptors in normal and Alzheimer's diseased human brain.
Journal of neurochemistry 1989;52(1):140-7.
1988: P Foley; Henry F Bradford; M Docherty; H Fillit; V N Luine; B McEwen; G Bucht; Bengt Winblad; John Hardy
Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease.
Journal of neurology 1988;235(8):466-71.
1988: John Hardy
Molecular biology and Alzheimer's disease: more questions than answers.
Trends in neurosciences 1988;11(7):293-4.
1988: Richard Frank Cowburn; John Hardy; P Roberts; R Briggs
Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease.
Brain research 1988;452(1-2):403-7.
1988: D E Bateman; John Hardy; J R McDermott; D S Parker; J A Edwardson
Amino acid neurotransmitter levels in gliomas and their relationship to the incidence of epilepsy.
Neurological research 1988;10(2):112-4.
1988: Richard Frank Cowburn; John Hardy; Peter J Roberts
Characterisation of Na+-independent L-[3H]glutamate binding sites in human temporal cortex.
Journal of neurochemistry 1988;50(6):1872-8.
1988: John Hardy; D C Davies
Alzheimer's disease.
British journal of hospital medicine 1988;39(5):372-3, 376-7.
1988: P R Dodd; J W Hambley; Richard Frank Cowburn; John Hardy
A comparison of methodologies for the study of functional transmitter neurochemistry in human brain.
Journal of neurochemistry 1988;50(5):1333-45.
1988: agneta nordberg; Abdu Adem; John Hardy; Bengt Winblad
Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains.
Neuroscience letters 1988;86(3):317-21.
1988: I O'Connor; Richard Frank Cowburn; John Hardy; C J Fowler
Dopamine and apomorphine do not modulate the uptake of [3H]D-aspartate in the rat striatum in-vitro.
The Journal of pharmacy and pharmacology 1988;40(4):307-8.
1988: Richard Frank Cowburn; John Hardy; P Roberts; R Briggs
Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease.
Neuroscience letters 1988;86(1):109-13.
1988: John Hardy
Mouse models of human neurogenetic disorders.
Trends in neurosciences 1988;11(3):89-90.
1988: D C Davies; John Hardy
Blood brain barrier in ageing and Alzheimer's disease.
Neurobiology of aging 1988;9(1):46-8.
1987: J D Turner; R J Boakes; John Hardy; M A Virmani
Efflux of putative transmitters from superfused rat brain slices induced by low chloride ion concentrations.
Journal of neurochemistry 1987;48(4):1060-8.
1987: John Hardy; Richard Frank Cowburn; A Barton; G Reynolds; P Dodd; P Wester; A M O'Carroll; E Lofdahl; Bengt Winblad
A disorder of cortical GABAergic innervation in Alzheimer's disease.
Neuroscience letters 1987;73(2):192-6.
1987: John Hardy; Richard Frank Cowburn; A Barton; G Reynolds; E Lofdahl; A M O'Carroll; P Wester; Bengt Winblad
Region-specific loss of glutamate innervation in Alzheimer's disease.
Neuroscience letters 1987;73(1):77-80.
1987: John Hardy; P Wester; I Backstrom; J Gottfries; L Oreland; A Stenstrom; Bengt Winblad
The regional distribution of dopamine and serotonin uptake and transmitter concentrations in the human brain.
Neurochemistry international 1987;10(4):445-50.
1987: Richard Frank Cowburn; P R Dodd; John Hardy; G A Johnston
A comparison of high affinity synaptosomal uptake of d-aspartate in rat and human brain.
Neurochemistry international 1987;10(3):339-46.
1987: L Nilsson; Abdu Adem; John Hardy; Bengt Winblad; agneta nordberg
Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brains via nicotinic receptors?
Journal of neural transmission 1987;70(3-4):357-68.
1986: G S Venables; A J Strong; S A Miller; G Gibson; John Hardy
The effects of etomidate in the cat middle cerebral artery occlusion model of brain ischaemia. An experimental study.
Neurological research 1986;8(4):209-13.
1986: John Hardy; D M A Mann; P Wester; Bengt Winblad
An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease.
Neurobiology of aging 1986;7(6):489-502.
1986: John Hardy; A Barton; E Lofdahl; S C Cheetham; Graham A R Johnston; P R Dodd
Uptake of gamma-aminobutyric acid and glycine by synaptosomes from postmortem human brain.
Journal of neurochemistry 1986;47(2):460-7.
1986: P R Dodd; John Hardy; E B Baig; A M Kidd; E D Bird; W E Watson; Graham A R Johnston
Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain.
Neurochemical pathology 1986;4(3):177-98.
1986: P Almqvist; Sven Carlsson; John Hardy; Bengt Winblad
Regional and subcellular distribution of Thy-1 in human brain assayed by a solid-phase radioimmunoassay.
Journal of neurochemistry 1986;46(3):681-5.
1986: L Nilsson; agneta nordberg; John Hardy; P Wester; Bengt Winblad
Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level.
Journal of neural transmission 1986;67(3-4):275-85.
1985: G S Venables; S A Miller; G Gibson; John Hardy; A J Strong
The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat.
Journal of neurology, neurosurgery, and psychiatry 1985;48(7):663-9.
1985: A Stenström; L Oreland; John Hardy; P Wester; Bengt Winblad
The uptake of serotonin and dopamine by homogenates of frozen rat and human brain tissue.
Neurochemical research 1985;10(5):591-9.
1985: P Nyberg; R Adolfsson; John Hardy; agneta nordberg; P Wester; Bengt Winblad
Catecholamine topochemistry in human basal ganglia. Comparison between normal and Alzheimer brains.
Brain research 1985;333(1):139-42.
1985: John Hardy; R Adolfsson; I Alafuzoff; G Bucht; J Marcusson; P Nyberg; E Perdahl; P Wester; Bengt Winblad
Transmitter deficits in Alzheimer's disease.
Neurochemistry international 1985;7(4):545-63.
1985: P Wester; D E Bateman; P R Dodd; J A Edwardson; John Hardy; A M Kidd; Robert H Perry; G B Singh
Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain.
Neurochemical pathology 1985;3(3):169-80.
1985: John Hardy; P Wester; Bengt Winblad; C Gezelius; G Bring; A Eriksson
The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue.
Journal of neural transmission 1985;61(3-4):253-64.
1985: Bengt Winblad; John Hardy; Lars Bäckman; L G Nilsson
Memory function and brain biochemistry in normal aging and in senile dementia.
Annals of the New York Academy of Sciences 1985;444():255-68.
1984: Elaine K Perry; J R Atack; Robert H Perry; John Hardy; P R Dodd; J A Edwardson; G Blessed; B E Tomlinson; Andrew F Fairbairn
Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal.
Journal of neurochemistry 1984;42(5):1402-10.
1984: John Hardy; R J Boakes; D J Thomas; A M Kidd; J A Edwardson; M Virmani; J Turner; P R Dodd
Release of aspartate and glutamate caused by chloride reduction in synaptosomal incubation media.
Journal of neurochemistry 1984;42(3):875-7.
1984: John Hardy; D E Bateman; A M Kidd; J A Edwardson; G B Singh; P R Dodd
Amino acid transport by synaptosomes isolated from post mortem human brain.
Journal of neural transmission 1984;60(1):57-62.
1984: P Wester; John Hardy; J Marcusson; P Nyberg; Bengt Winblad
Serotonin concentrations in normal aging human brains: relation to serotonin receptors.
Neurobiology of aging 1984;5(3):199-203.
1983: John Hardy; P R Dodd; A E Oakley; Robert H Perry; J A Edwardson; A M Kidd
Metabolically active synaptosomes can be prepared from frozen rat and human brain.
Journal of neurochemistry 1983;40(3):608-14.
1983: A J Strong; B E Tomlinson; G S Venables; G Gibson; John Hardy
The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 2. Studies of histopathology, water content, and in vitro neurotransmitter uptake.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1983;3(1):97-108.
1983: J R McDermott; P R Dodd; J A Edwardson; John Hardy; A I Smith
Pathway of inactivation of cholecystokinin octapeptide (CCK-8) by synaptosomal fractions.
Neurochemistry international 1983;5(5):641-7.
1983: John Hardy; P R Dodd
Metabolic and functional studies on post-mortem human brain.
Neurochemistry international 1983;5(3):253-66.
1983: J R McDermott; A I Smith; P R Dodd; John Hardy; J A Edwardson
Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases.
Peptides 1983;4(1):25-30.
1982: John Hardy; P R Dodd; A E Oakley; A M Kidd; Robert H Perry; J A Edwardson
Use of post-mortem human synaptosomes for studies of metabolism and transmitter amino acid release.
Neuroscience letters 1982;33(3):317-22.
1981: P R Dodd; John Hardy; A E Oakley; J A Edwardson; Elaine K Perry; J P Delaunoy
A rapid method for preparing synaptosomes: comparison, with alternative procedures.
Brain research 1981;226(1-2):107-18.
1981: P Dodd; John Hardy; A E Oakley; A J Strong
Synaptosomes prepared from fresh human cerebral cortex; morphology, respiration and release of transmitter amino acids.
Brain research 1981;224(2):419-25.
1980: G P Reynolds; M Sandler; John Hardy; H Bradford
The determination and distribution of 2-phenylethylamine in sheep brain.
Journal of neurochemistry 1980;34(5):1123-5.
1980: John Hardy; Jackie de Belleroche; D Border; H F Bradford
Differential transmitter release from nerve terminals isolated from basal ganglia and substantia nigra.
Journal of neurochemistry 1980;34(5):1130-9.
1980: M Somma; E Rasio; H Beauregard; John Hardy
[Pituitary adenomas. Surgical treatment by transphenoidal approach].
L'unión médicale du Canada 1980;109(1):68-81.
1979: P R Dodd; John Hardy; H F Bradford; G W Bennett; J A Edwardson; B N Harding
Metabolic and secretory processes in nerve-endings isolated from post-mortem brain.
Neuroscience letters 1979;11(1):87-92.
1975: P Molina-Negro; John Hardy
Semiology of Tremors.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1975;2(1):23-9.
1972: F C Velasco; P Molina-Negro; C Bertrand; John Hardy
Further definition of the subthalamic target for arrest of tremor.
Journal of neurosurgery 1972;36(2):184-91.
1971: P Molina-Negro; John Hardy
[Semeiological study of trembling].
L'unión médicale du Canada 1971;100(5):879-95.
1970: R Papeschi; P Molina-Negro; T L Sourkes; John Hardy; C Bertrand
Concentration of homovanillic acid in the ventricular fluid of patients with Parkinson's disease and other dyskinesias.
Neurology 1970;20(10):991-5.
1970: R Papeschi; P Molina-Negro; T L Sourkes; John Hardy; C Bertrand
Homovanillic acid in the ventricular fluid of patients with Parkinson's disease and other extrapyramidal diseases.
Laval médical 1970;41(7):899-901.
1970: John Hardy; P Molina-Negro; C Bertrand; N S Martinez
[Tremor of attitude: physiopathologic study].
L'unión médicale du Canada 1970;99(3):449-56.
1969: C Bertrand; John Hardy; P Molina-Negro; S N Martinez
Tremor of attitude.
Confinia neurologica 1969;31(1):37-41.
1965: John Hardy; C Bertrand
Electrophysiological exploration of sub-cortical structures with microelectrode during stereotaxic surgery.
Confinia neurologica 1965;26(3):201-4.
1962: G GUIOT; John Hardy; D ALBE-FESSARD
[Precise delimitation of the subcortical structures and identification of thalamic nuclei in man by stereotactic electrophysiology].
Neurochirurgia 1962;5():1-18.
1961: John Hardy
[Neurophysiological mechanisms of parkinsonian tremor].
L'unión médicale du Canada 1961;90():131-47.
1961: A BARBEAU; R GIGUERE; John Hardy
[Clinical experience with tolbutamide in Parkinson's disease].
L'unión médicale du Canada 1961;90():147-51.