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Edward Harhaj

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TOP 3
Soratree Charoenthongtrakul; Linlin Gao; David Lee; Kislay Parvatiyar; Edward W Harhaj
RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.
Soratree Charoenthongtrakul; Linlin Gao; Edward W Harhaj
The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling.
Edward W Harhaj; Vishva M Dixit
Regulation of NF-κB by deubiquitinases.

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All Publications

2013: Soratree Charoenthongtrakul; Linlin Gao; David Lee; Kislay Parvatiyar; Edward W Harhaj
RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.
PloS one 2013;8(1):e53717.
2012: Soratree Charoenthongtrakul; Linlin Gao; Edward W Harhaj
The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling.
Cellular & molecular immunology 2012;9(6):431-3.
2012: Edward W Harhaj; Vishva M Dixit
Regulation of NF-κB by deubiquitinases.
Immunological reviews 2012;246(1):107-24.
2012: Noula Dattu Shembade; Edward W Harhaj
Regulation of NF-κB signaling by the A20 deubiquitinase.
Cellular & molecular immunology 2012;9(2):123-30.
2012: Alfonso Lavorgna; Edward W Harhaj
An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.
Journal of virology 2012;86(6):3357-69.
2012: Alfonso Lavorgna; Edward W Harhaj
EBV LMP1: New and shared pathways to NF-κB activation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2188-9.
2011: Noula Dattu Shembade; Edward W Harhaj
IKKi: a novel regulator of Act1, IL-17 signaling and pulmonary inflammation.
Cellular & molecular immunology 2011;8(6):447-9.
2011: Linlin Gao; Susan Grant; Steven C Ley; Averil Ma; Helen Coope; Edward W Harhaj
ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.
The Journal of biological chemistry 2011;286(42):36592-602.
2011: Noula Dattu Shembade; Derek W Abbott; Nicole S Harhaj; Rajeshree Pujari; Edward W Harhaj
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Nature immunology 2011;12(9):834-43.
2011: Soratree Charoenthongtrakul; Nicole S Harhaj; Noula Dattu Shembade; Qinjie Zhou; Edward W Harhaj
Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1.
Journal of virology 2011;85(14):6955-62.
2011: Kislay Parvatiyar; Edward W Harhaj
Regulation of inflammatory and antiviral signaling by A20.
Microbes and infection / Institut Pasteur 2011;13(3):209-15.
2011: Edward W Harhaj; Vishva M Dixit
Deubiquitinases in the regulation of NF-κB signaling.
Cell research 2011;21(1):22-39.
2010: Noula Dattu Shembade; Edward W Harhaj
A20 inhibition of NFκB and inflammation: targeting E2:E3 ubiquitin enzyme complexes.
Cell cycle (Georgetown, Tex.) 2010;9(13):2481-2.
2010: Kislay Parvatiyar; Edward W Harhaj
Cell signaling. Anchors away for ubiquitin chains.
Science (New York, N.Y.) 2010;328(5983):1244-5.
2010: Kislay Parvatiyar; Glen N Barber; Edward W Harhaj
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases.
The Journal of biological chemistry 2010;285(20):14999-5009.
2010: Giselle Perry; Viyaya Iragavarapu-Charyulu; Edward W Harhaj; Marta Torroella-Kouri
Role of the proteasome in the downregulation of transcription factors NFkappaB and C/EBP in macrophages from tumor hosts.
Oncology reports 2010;23(3):875-81.
2010: Noula Dattu Shembade; Averil Ma; Edward W Harhaj
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.
Science (New York, N.Y.) 2010;327(5969):1135-9.
2010: Noula Dattu Shembade; Edward W Harhaj
Role of post-translational modifications of HTLV-1 Tax in NF-κB activation.
World journal of biological chemistry 2010;1(1):13-20.
2009: Mingfang Tao; Peter C Scacheri; Jill M Marinis; Edward W Harhaj; Lydia E Matesic; Derek W Abbott
ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.
Current biology : CB 2009;19(15):1255-63.
2009: Noula Dattu Shembade; Kislay Parvatiyar; Nicole S Harhaj; Edward W Harhaj
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.
The EMBO journal 2009;28(5):513-22.
2008: Noula Dattu Shembade; Nicole S Harhaj; Kislay Parvatiyar; Neal G Copeland; Nancy A Jenkins; Lydia E Matesic; Edward W Harhaj
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.
Nature immunology 2008;9(3):254-62.
2007: Noula Dattu Shembade; Nicole S Harhaj; Masahiro Yamamoto; Shizuo Akira; Edward W Harhaj
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Journal of virology 2007;81(24):13735-42.
2007: Noula Dattu Shembade; Nicole S Harhaj; Daniel J Liebl; Edward W Harhaj
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
The EMBO journal 2007;26(17):3910-22.
2007: Nicole S Harhaj; Branislava Janic; Juan Carlos Ramos; William J Harrington; Edward W Harhaj
Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients.
Virology 2007;362(1):99-108.
2007: Juan Carlos Ramos; Phillip Ruiz; Lee Ratner; Isildinha M Reis; Carlos Brites; Celia Pedroso; Gerald E Byrne; Ngoc L Toomey; Valentine Andela; Edward W Harhaj; Izidore S Lossos; William J Harrington
IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma.
Blood 2007;109(7):3060-8.
2007: Nicole S Harhaj; Shao-Cong Sun; Edward W Harhaj
Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase.
The Journal of biological chemistry 2007;282(6):4185-92.
2006: Masahito Kamanaka; Sean T Kim; Yisong Y Wan; Fayyaz S Sutterwala; María Lara-Tejero; Jorge E Galán; Edward W Harhaj; Richard A Flavell
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.
Immunity 2006;25(6):941-52.
2006: Jing Yao; Christian Grant; Edward W Harhaj; Michael Nonnemacher; Timothy Alefantis; Joel Martin; Pooja Jain; Brian Wigdahl
Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III.
DNA and cell biology 2006;25(5):262-76.
2005: Timothy Alefantis; Kate Mostoller; Pooja Jain; Edward W Harhaj; Christian Grant; Brian Wigdahl
Secretion of the human T cell leukemia virus type I transactivator protein tax.
The Journal of biological chemistry 2005;280(17):17353-62.
2005: Edward W Harhaj; Nicole S Harhaj; Christian Grant; Kate Mostoller; Timothy Alefantis; Shao-Cong Sun; Brian Wigdahl
Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway.
Virology 2005;333(1):145-58.
2005: Edward W Harhaj; Nicole S Harhaj
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
IUBMB life 2005;57(2):83-91.
2004: Liao Gongxian; Minying Zhang; Edward W Harhaj; Shao-Cong Sun
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.
The Journal of biological chemistry 2004;279(25):26243-50.
2003: Kate Barmak; Edward W Harhaj; Brian Wigdahl
Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis.
Journal of neurovirology 2003;9(5):522-9.
2003: Timothy Alefantis; Kate Barmak; Edward W Harhaj; Christian Grant; Brian Wigdahl
Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax.
The Journal of biological chemistry 2003;278(24):21814-22.
2003: Kate Barmak; Edward W Harhaj; Christian Grant; Timothy Alefantis; Brian Wigdahl
Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration.
Virology 2003;308(1):1-12.
2001: Gutian Xiao; Mary Ellen Cvijic; Abraham Fong; Edward W Harhaj; MT Uhlik; Michael Waterfield; Shao-Cong Sun
Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha.
The EMBO journal 2001;20(23):6805-15.
2001: Gutian Xiao; Edward W Harhaj; Shao-Cong Sun
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
Molecular cell 2001;7(2):401-9.
2000: Gutian Xiao; Edward W Harhaj; Shao-Cong Sun
Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.
The Journal of biological chemistry 2000;275(44):34060-7.
2000: Shao-Cong Sun; Edward W Harhaj; Gutian Xiao; L Good
Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.
AIDS research and human retroviruses 2000;16(16):1591-6.
2000: Edward W Harhaj; L Good; Gutian Xiao; MT Uhlik; Mary Ellen Cvijic; I Rivera-Walsh; Shao-Cong Sun
Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein.
Oncogene 2000;19(11):1448-56.
1999: A Dharshan De Silva; Alina Boesteanu; R Song; N Nagy; Edward W Harhaj; C V Harding; Sebastian JOYCE
Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4413-20.
1999: Edward W Harhaj; Shao-Cong Sun
Regulation of RelA subcellular localization by a putative nuclear export signal and p50.
Molecular and cellular biology 1999;19(10):7088-95.
1999: Edward W Harhaj; Shao-Cong Sun
IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein.
The Journal of biological chemistry 1999;274(33):22911-4.
1999: Shao-Cong Sun; SB Maggirwar; Edward W Harhaj; MT Uhlik
Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells.
Oncogene 1999;18(7):1401-9.
1999: Edward W Harhaj; L Good; Gutian Xiao; Shao-Cong Sun
Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation.
Oncogene 1999;18(6):1341-9.
1998: Edward W Harhaj; Shao-Cong Sun
IkappaB kinases serve as a target of CD28 signaling.
The Journal of biological chemistry 1998;273(39):25185-90.
1998: I Rivera; Edward W Harhaj; Shao-Cong Sun
Involvement of NF-AT in type I human T-cell leukemia virus Tax-mediated Fas ligand promoter transactivation.
The Journal of biological chemistry 1998;273(35):22382-8.
1998: Min-Ying Zhang; Edward W Harhaj; L Bell; Shao-Cong Sun; Barbara A Miller
Bcl-3 expression and nuclear translocation are induced by granulocyte-macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors.
Blood 1998;92(4):1225-34.
1998: MT Uhlik; L Good; Gutian Xiao; Edward W Harhaj; E Zandi; Michael Karin; Shao-Cong Sun
NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.
The Journal of biological chemistry 1998;273(33):21132-6.
1997: SB Maggirwar; Edward W Harhaj; Shao-Cong Sun
Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors.
Molecular and cellular biology 1997;17(5):2605-14.
1997: Edward W Harhaj; Shao-Cong Sun
The serine/threonine phosphatase inhibitor calyculin A induces rapid degradation of IkappaBbeta. Requirement of both the N- and C-terminal sequences.
The Journal of biological chemistry 1997;272(9):5409-12.
1997: L Good; SB Maggirwar; Edward W Harhaj; Shao-Cong Sun
Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells.
The Journal of biological chemistry 1997;272(3):1425-8.
1996: Edward W Harhaj; S B Maggirwar; L Good; Shao-Cong Sun
CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers.
Molecular and cellular biology 1996;16(12):6736-43.
1996: Edward W Harhaj; S B Maggirwar; Shao-Cong Sun
Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells.
Oncogene 1996;12(11):2385-92.
1996: Edward W Harhaj; J Blaney; S Millhouse; Shao-Cong Sun
Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR.
Virology 1996;216(1):284-7.
1995: S B Maggirwar; Edward W Harhaj; Shao-Cong Sun
Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor.
Oncogene 1995;11(5):993-8.
1995: Shao-Cong Sun; S B Maggirwar; Edward W Harhaj
Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
The Journal of biological chemistry 1995;270(31):18347-51.