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Valsala Haridas

Research Profile

Chemicals & Drugs

Living Beings

Acacia

Physiology

Anatomy

Phenomena

Protein Binding

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Publications

TOP 3
Valsala Haridas; Anna Jiang; Doug Kitchen; Peter Michels; Zhi-Xiang Xu; Jordan U Gutterman
The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism.
Mauricio Arias; Jairo C Quijano; Valsala Haridas; Jordan U Gutterman; Victor V Lemeshko
Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins.
Huibo Wang; Valsala Haridas; Jordan U Gutterman; Zhi-Xiang Xu
Natural triterpenoid avicins selectively induce tumor cell death.

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All Publications

2011: Valsala Haridas; Anna Jiang; Doug Kitchen; Peter Michels; Zhi-Xiang Xu; Jordan U Gutterman
The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism.
PloS one 2011;6(11):e28037.
2010: Mauricio Arias; Jairo C Quijano; Valsala Haridas; Jordan U Gutterman; Victor V Lemeshko
Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins.
Biochimica et biophysica acta 2010;1798(6):1189-96.
2010: Huibo Wang; Valsala Haridas; Jordan U Gutterman; Zhi-Xiang Xu
Natural triterpenoid avicins selectively induce tumor cell death.
Communicative & integrative biology 2010;3(3):205-8.
2009: Zhi-Xiang Xu; Tian Ding; Valsala Haridas; Fiona Connolly; Jordan U Gutterman
Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts.
PloS one 2009;4(12):e8532.
2009: Valsala Haridas; Goshi Nishimura; Zhi-Xiang Xu; Fiona Connolly; Margaret Hanausek; Zbigniew Walaszek; Robert Zoltaszek; Jordan U Gutterman
Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities.
PloS one 2009;4(5):e5578.
2008: Chunlei Zhang; Baoqiang Li; Amos Gaikwad; Valsala Haridas; Zhixiang Xu; Jordan U Gutterman; Madeleine Duvic
Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells.
The Journal of investigative dermatology 2008;128(11):2728-35.
2007: Zhi-Xiang Xu; Jiyong Liang; Valsala Haridas; Amos Gaikwad; F P Connolly; Gordon B Mills; Jordan U Gutterman
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.
Cell death and differentiation 2007;14(11):1948-57.
2007: Valsala Haridas; Xiaoxian Li; Takatsugu Mizumachi; Masahiro Higuchi; Victor V Lemeshko; Marco Colombini; Jordan U Gutterman
Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane.
Mitochondrion 2007;7(3):234-40.
2006: Victor V Lemeshko; Valsala Haridas; Jairo C Quijano Pérez; Jordan U Gutterman
Avicins, natural anticancer saponins, permeabilize mitochondrial membranes.
Archives of biochemistry and biophysics 2006;454(2):114-22.
2005: Jordan U Gutterman; Hong T Lai; Peirong Yang; Valsala Haridas; Amos Gaikwad; Stevan Marcus
Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12771-6.
2005: Valsala Haridas; Sung-Oog Kim; Goshi Nishimura; Alfred Hausladen; Jonathan S Stamler; Jordan U Gutterman
Avicinylation (thioesterification): a protein modification that can regulate the response to oxidative and nitrosative stress.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10088-93.
2005: Xiao Xian Li; Bridgette Davis; Valsala Haridas; Jordan U Gutterman; Marco Colombini
Proapoptotic triterpene electrophiles (avicins) form channels in membranes: cholesterol dependence.
Biophysical journal 2005;88(4):2577-84.
2005: Neil W Blackstone; Molly M Kelly; Valsala Haridas; Jordan U Gutterman
Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite.
Proceedings. Biological sciences / The Royal Society 2005;272(1562):527-31.
2005: Amos Gaikwad; Ann Poblenz; Valsala Haridas; Chunlei Zhang; Madeleine Duvic; Jordan U Gutterman
Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1953-62.
2004: Valsala Haridas; Margaret Hanausek; Goshi Nishimura; Holly Soehnge; Amos Gaikwad; Maciej Narog; Erick Spears; Robert Zoltaszek; Zbigniew Walaszek; Jordan U Gutterman
Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery.
The Journal of clinical investigation 2004;113(1):65-73.
2003: Gamini S Jayatilake; Delano R Freeberg; Zhengjie Liu; Steven L Richheimer; Mary E Blake Nieto; David T Bailey; Valsala Haridas; Jordan U Gutterman
Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae.
Journal of natural products 2003;66(6):779-83.
2002: Lokesh Joshi; Joyce M Van Eck; Kristin Mayo; Regina Di Silvestro; Mary E Blake Nieto; Thumballi Ganapathi; Valsala Haridas; Jordan U Gutterman; Charles J Arntzen
Metabolomics of plant saponins: bioprospecting triterpene glycoside diversity with respect to mammalian cell targets.
Omics : a journal of integrative biology 2002;6(3):235-46.
2001: Valsala Haridas; Charles J Arntzen; Jordan U Gutterman
Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11557-62.
2001: Kalpana Mujoo; Valsala Haridas; JJ Hoffmann; Gerald A Wächter; L K Hutter; Ying Lu; ME Blake; Gamini S Jayatilake; D Bailey; Gordon B Mills; Jordan U Gutterman
Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.
Cancer research 2001;61(14):5486-90.
2001: Valsala Haridas; M Higuchi; Gamini S Jayatilake; D Bailey; Kalpana Mujoo; ME Blake; Charles J Arntzen; Jordan U Gutterman
Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5821-6.
2000: S K Manna; Valsala Haridas; Bharat B Aggarwal
Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(8):725-35.
1999: Valsala Haridas; A Shrivastava; J Su; GL Yu; Jian Ni; D Liu; S F Chen; Y Ni; Steve Ruben; Reiner Gentz; Bharat B Aggarwal
VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth.
Oncogene 1999;18(47):6496-504.
1998: Bryant G Darnay; Valsala Haridas; Jian Ni; Paul Moore; Bharat B Aggarwal
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.
The Journal of biological chemistry 1998;273(32):20551-5.
1998: Byoung S Kwon; S Wang; N Udagawa; Valsala Haridas; Z H Lee; K K Kim; KO Oh; J Greene; Y Li; J Su; Reiner Gentz; Bharat B Aggarwal; Jian Ni
TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(10):845-54.
1998: Valsala Haridas; Jian Ni; A Meager; J Su; GL Yu; Y Zhai; H Kyaw; KT Akama; J Hu; Linda Van Eldik; Bharat B Aggarwal
TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):1-6.
1998: Valsala Haridas; Bryant G Darnay; K Natarajan; R Heller; Bharat B Aggarwal
Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3152-62.